Bookedited [by] Peter Paul De Deyn and Debby Van Dam.
Contents:
General introduction to animal models of human conditions / Peter Paul De Deyn and Debby Van Dam
Animal models of dementia : ethical considerations / I. Anna S. Olsson and Peter Sandøe
The role of rodent models in the drug discovery pipeline for dementia / Debby Van Dam and Peter Paul De Deyn
Species, strain, and gender issues in the development and validation of animal models of dementia / Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn
Transgenic and gene targeted models of dementia / Ronald A. Conlon
Transgenic animals and intellectual property concerns / Susan L. Stoddard and James A. Rogers III
Pathological validation of animal models of dementia / Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh
Behavioral validation in animal models of dementia / Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn
Pharmacological validation in animal models of dementia / Hugo Geerts
Validation of animal models of dementia : neurochemical aspects / Giancarlo Pepeu and Maria Cristina Rosi
Validation of dementia models employing neuroimaging techniques / Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden
Drosophila melanogaster as a model organism for dementia / Maria E. Giannakou and Damian C. Crowther
Caenorhabditis elegans as a model organism for dementia / Tjakko J. Van Ham and Ellen A.A. Nollen
Zebrafish (Danio rerio) as a model organism for dementia / Rob Willemsen ... [et al.]
Spontaneous vertebrate models of Alzheimer dementia : selectively bred strains (SAM strains) / Renã A. Sowell and D. Allan Butterfield
Lesion-induced vertebrate models of Alzheimer dementia / Adolfo Toledano and Maria Isabel Álvarez
A[Beta] infusion and related models of Alzheimer dementia / Patricia A. Lawlor and Deborah Young
APP-based transgenic models : the PDAPP model / Jacob M. Basak and David M. Holtzman
APP-based transgenic models : the Tg2576 model / Robert M.J. Deacon
APP-based transgenic models : the APP23 model / Debby Van Dam and Peter Paul De Deyn
Presenilin-based transgenic models of Alzheimer's dementia / Yuji Yoshiike and Akihiko Takashima
APOE-based models of "pre-dementia" / Patrick M. Sullivan
TAU models / Nicolas Sergeant and Luc Buée
The 3xTg-AD mouse model : reproducing and modulating plaque and tangle pathology / Michael Sy, Masashi Kitazawa, and Frank LaFerla
Cognitive dysfunction in genetic mouse models of parkinsonism / Sheila M. Fleming, J. David Jentsch, and Marie-Françoise Chesselet
Mouse models of metachromatic leukodystrophy and adrenoleukodystrophy / Patrick Aubourg, Caroline Sevin, and Nathatie Cartier
Animal models of amyotrophic lateral sclerosis / Ludo Van Den Bosch
Animal models of frontotemporal dementia / Hana N. Dawson and Daniel T. Laskowitz
CADASIL : molecular mechanisms and animal models / Karl J. Fryxell
Spontaneously hypertensive rat (SHR) : an animal model of vascular brain disorder / Francesco Amenta and Daniele Tomassoni
Animal models of normal pressure hydrocephalus / Petra M. Klinge
Animal models of traumatically-induced dementia / Jennifer E. Slemmer, Mohammad Z. Hossain, and John T. Weber
Animal models of alcohol-induced dementia / Angela Maria Ribeiro and Silvia R. Castanheira Pereira
Animal models of metallic dementia / Luigi F. Rodella.