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  • Book
    edited by Zahid H. Siddik.
    Digital : Springer2010
    1. Circuitry of Checkpoint Response -- Evasion of G1 Checkpoints in Cancer -- Distinct Pathways Involved in S-Phase Checkpoint Control -- Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response -- 2. Checkpoint Response and the Aetiology of Cancer -- Chromatin Modifications and Orchestration of Checkpoint Response in Cancer -- DNA Damage Response and the Balance Between Cell Survival and Cell Death -- Dysfunction of the RB Retinoblastoma Gene in Cancer -- G1 Phase Cyclins in Cancer Development and Progression -- The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls -- 3. Targeting Checkpoint Response in Cancer Therapy -- Regulation of p53 Activity and Associated Checkpoint Controls -- The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors -- Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy -- p27Kip1 as a Biomarker and Target for Treatment of Cancer -- Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors -- Chk1 and Chk2 as Checkpoint Targets -- Targeting Cdc25 Phosphatases in Cancer Therapy.