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- ArticleBardy M, Tsacopoulos M.Klin Monbl Augenheilkd. 1978 Apr;172(4):451-60.Experimental microembolisation provokes hemodynamics and metabolic changes in the inner retina. The metabolic modifications are the consequence of focal tissue ischaemia and have as a main feature, the activation of anaerobic glycolysis. This activation produces an increase in the production of lactic acid which, in turn, causes a drop of tissular pH. Choroidal circulation maintains photoreceptors in a physiological state.