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  • Book
    Digital Access
    Provider
    Version
    TandFonline
    v. 315-, 2005-
    CINAHL
    v. 315-363, 2005-16.
    Access via Acta orthopaedica 2005-
    Location
    Version
    Call Number
    Items
    Acta orthopaedica 2005-
    v. 315-319, 2005.
    No. 315-319 BOUND WITH: Acta orthopaedica v. 76.
  • Article
    Webb RC, Bohr DF.
    Blood Vessels. 1979;16(2):71-9.
    Helical strips of tail artery from spontaneously hypertensive (SHR) and Kyoto Wistar normotensive rats (WKY) were observed to relax in response to potassium after contraction induced by norepinephrine in potassium-free solution. Helical strips from SHR consistently showed greater relaxation in response to the addition of potassium than did those from WKY. The amplitude of potassium-induced relaxation is believed to be an index of the activity of electrogenic sodium-potassium transport and hence of sodium-potassium ATPase. Thus, the sodium-potassium ATPase activity of SHR vascular smooth muscle is increased as compared to WKY. This interpretation is supported by the observation that ouabain eliminated potassium-induced relaxation in both SHR and WKY strips. Potassium-induced relaxation in SHR was more sensitive to ouabain inhibition than in WKY. Relaxation induced by potassium in SHR and WKY strips was also shown to vary with: (1) the length of incubation in potassium-free solution, and (2) the concentration of potassium added back. The results of these experiments on potassium-induced relaxation serve as evidence that SHR have either an increased intrinsic sodium-potassium ATPase activity, or an enzyme activity that has been stimulated to a greater degree by an elevated intracellular sodium concentration which resulted from the incubation in potassium-free solution.
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