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  • Journal
    Print Access
    Location
    Version
    Call Number
    Items
    Reference (Shelved at Information Desk)
    1988.
    RT82 .A312
    Retired Reference (Downstairs)
    1982-87
    RT82 .A312
    7
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  • Article
    Seiler JP.
    Mutat Res. 1977 Apr;48(2):225-36.
    37 nitrogenous pesticides, belonging to the chemical groups of amides, carbamates and ureas, were nitrosated with sodium nitrite in vitro. The nitrosated compounds were tested for mutagenic activity in the bacterial spot test with Salmonella typhimurium his G 46. Those pesticides reacting positively in this test after nitrosation were then fed to mice in combination with sodium nitrite in order to assess the formation and mutagenicity of these nitroso compounds in vivo. With the already known exception of ethylenethiourea (ETU), no pesticide produced enhanced numbers of micronuclei in mouse bone-marrow erythrocytes when fed together with nitrite. Dose-response experiments with intraperitoneal injection of N-nitroso-ETU revealed an apparent no-effect level of about 15--18 mg/kg. The findings are correlated with the pesticide residues actually present in the environment.
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