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    Retired Reference Periodicals (Downstairs)
    1980/96-1997, 1999/2000.
    SHELVED AS A PERIODICAL UNDER: Data summary (Sacramento, Calif.).
  • Article
    Drew AH, Rundle AT.
    J Ment Defic Res. 1977 Sep;21(3):191-8.
    The observation elsewhere (Drew and Rundle, 1977) that increase frequencies of the C5 + variant of the serum cholinesterase in Down's syndrome may be due to a protective influence against adverse environmental factors has been investigated for such factors as age, sex, duration of institutionalisation, presence of the hepatitis -B antigen and maternal age. With the exception of the maternal age none of the factors tested appear to affect the circulating levels of cholinesterase. A maternal age effect in the Down's subjects was detected with lower levels of the enzyme being found in the subject positive for the C5 + variant born to mothers over thirty-five years when compared to the C5 + subjects born to mothers under thirty-five years. Further studies confirmed the presence of a relationship between maternal age, serum cholinesterase levels and haptoglobin phenotypes.
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