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- ArticleBoggan WO, Meyer JS.Res Commun Chem Pathol Pharmacol. 1977 Apr;16(4):629-36.Methaqualone (75 mg/kg) produced a significant decrease in the rectal temperature of mice. This effect was antagonized by parachlorophenylalanine and potentiated by Lilly 110140. These compounds also decreased and increased respectively the circulating concentration of methaqualone.