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    Summary: CenterWatch clinical trials listing service is an international listing of clinical research trials. It can be used to search for clinical trials, find out information about physicians and medical centers performing clinical research, and to learn about drug therapies newly approved by the Food and Drug Administration (FDA).
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  • Article
    Russell P, Fukui HN, Tsunematsu Y, Huang FL, Konoshita JH.
    Invest Ophthalmol Vis Sci. 1977 Mar;16(3):243-6.
    Lens epithelial cells from normal and Nakano adult mice have been cultured for over 1 year, and the cells have retained certain differentiated characteristics. Fluorescent antibody to mouse gamma crystallin reacted with the spherical lentoid bodies which appeared approximately 2 weeks after the start of the culture. The lentoid bodies also contained cells which had few cell organelles and homogenous cytoplasms. Both gamma crystallin production and loss of cellular organelles are characteristics of differentiated fiber cells rather than epithelial cells. An inhibitor of the Na-K ATPase is responsible for the hydration and subsequent cataract formation in the Nakamo mouse. The inhibitor of the Na-K ATPase was demonstrated in the lens in culture from the Nakamo mice, but no inhibitory activity was detected in the cultures from normal mice.
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