Books by Subject

Toxicology

  • Digital
    edited by George J. Kahaly.
    Springer2021
    This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.
  • Digital
    Chang-Hwei Chen.
    Springer2012
  • Digital
    edited by Grant N. Pierce, Volodymyr I. Mizin and Alexander Omelchenko.
    Springer2013
    "The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.
  • Digital
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Springer2013
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Digital
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Springer2013
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Digital
    Yi-Chun Zhu, editor.
    Springer2021
    Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.
  • Digital
    edited by Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova.
    ScienceDirect2012
    A. Engineered nanomaterials: hazard, exposure and safety assessment. Interactions with the human body / Renato Colognato ... [et al.] -- Exposure assessment / Antonio Bergamaschi, Ivo Iavicoli and Kai Savolainen -- Biomonitoring / Enrico bergamaschi and Andrea Magrini -- Critical evaluation of toxicity tests / Maria Dusinska ... [et al.] -- Computational approaches / Vidana Epa, Dave Winkler and Lang Tran -- Regulation and legislation / Maureen R. Gwinn and Birgit Sokull-Klüttgen -- B. Engineered nanomaterials: impact on human health. Respiratory system / Ken Donaldson and Craig Poland -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills and Rodger Duffin -- Neurological system / Sandra Ceccatelli and Giuseppe Bardi -- Immune system / Diana Boraschi and Albert Duschl -- Skin / Nancy A. Monteiro-Riviere and Francesca Larese Filon -- Gastrointestinal tract / Mark A. Jepson -- Reproductive toxicity / Karin Sørig Hougaard and Luisa Campagnolo -- Genotocicity and cancer / Shareen H. Doak, Ying Liu and Chunying Chen -- C. Biomedical applications of engineered nanomaterials. Diagnostic applications / Kalcheng and Zhen Cheng -- Therapeutic applications / Cyrill Bussy ... [et al.] -- Annex: synthesis of engineered nanomaterials / Muhammet S. toprak, Gulaim A. Seisenbaeva and Vadim G. Kessler.
  • Digital
    edited by Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova.
    ScienceDirect2017
    Bio-nano interactions / Dana Westmeier, Shirley K. Knauer, Roland H. Stauber, Dominic Docter -- Physicochemical characterization / Kristen Rasmussen, Hubert Rauscher, Agnieszka Mech -- Toxicity tests / Maria Dusinska, Elise Rundén-Pran, Jürgen Schnekenburger, Jun Kanno -- Computational approaches / Tu C. Le, Vidana Epa, Lang Tran, Dave Winkler -- Exposure Assessment / Kai Savolainen, Antonio Pietroiusti -- Biomonitoring / Enrico Bergamaschi, Irirna Guseva Canu, Adriele Prina-Mello, Regulation and legislation / Kirsten Rasmussen, Brigit Sokull-Klüttgen, IL Je Yu, Jun Kanno, Akihiro Hirose, Maureen R. Gwinn -- Risk assessment and risk management / Robert Landsiedel, Ursula G. Sauer, Wim H De Jong -- Respiratory system, part one / Craig A. Plooand, Ken Donaldson -- Respiratory system, part two / Harri Alenius, Michael R. Shurin, Galina V. Shurin, Don Beezhold, Anna A. Shvedova -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills, Rodger Duffin -- Neurological system / Myrtill Simkó, Mats-olof Mattsson, Robert A. Yokel -- Immune system / Diana Boraschi, Bengt Fadeel, Albert Duschl -- Endorine system / Xuefei Lu, Yong Zhu, Tao Zhu -- Skin / Nancy A. Monteiro-Riviere, Francesca Larese Filon -- Gastrointestinal system / Mark A. Jepson, Hans Bouwmeester -- Reproduction and development / Luisa Campagnolo, Karin S. Hougard -- Genotoxicitiy and cancer / Shareen H. Doak, Ying Liu, Chunying Chen.
  • Digital/Print
    IOMC, Inter-Organization Programme for the Sound Management of Chemicals.
    Digital : WHO2013
    Print2013
  • Print
    editors: Cheryl J. Cherpitel [and others].
  • Digital
    NLM2016
  • Digital
    edited by Marc A. Williams.
    ScienceDirect2011
    An introduction to allergic inflammation and the innate immune sensing of dangerous ambient pollutants by the dendritic cell -- Asthma: primary immunomodulatory pathways -- Environmental lung injury and pattern recognition receptors -- Asthma exacerbations: a paradigm of synergy between allergens, pollutants and viruses -- Bronchial hyperresponsiveness and lung inflammation induced by allergic immune response and oxidative stress: role of innate and adaptive immune responses -- Effects of air pollutants on allergic sensitization through the airway -- Particulate matter and oxidative stress: dangerous partners in inflammation, vascular dysfunction and innate immunity -- Diesel exhaust particles and the airway epithelial cell -- dendritic cell interface in the control of immune homeostasis -- Role of macrophages in adverse pulmonary effects of particulate pollutants -- Particulate air pollution and vulnerability to respiratory infections in children -- The intersection of respiratory syncytial virus infection, innate immunity and allergic lung disease -- Interactions between allergens and dendritic cells: pattern recognition receptors and their function in the pathogenesis of allergic respiratory diseases.
  • Digital
    edited by Akira Ohsaka, Kyozo Hayashi, and Yoshio Sawai.
    Springer1976
    v. 1. Biochemistry.
  • Digital
    Aimin Liu, editor.
    Springer2020
    This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects.
  • Digital
    Nitish Kumar, editor.
    Springer2021
    Springer Nature eBook.
    Arsenic (As) is a widely distributed element in the environment having no known useful physiological function in plants or animals. Historically, this metalloid has been known to be used widely as a poison. Effects of arsenic have come to light in the past few decades due to its increasing contamination in several parts of world, with the worst situation being in Bangladesh and West Bengal in India. This edited volume brings together diverse group of environmental science, sustainability and health researchers to address the challenges posed by global mass poisoning caused by arsenic water contamination. The book covers sources of arsenic contamination, and its impact on human health and on prospective remediation both by bioremediation and phytoremediation. Applications of advance techniques such as genetic engineering and nanotechnology are also discussed to resolve the issue of arsenic contamination in ground water and river basins. The book sheds light on this global environmental issue, and proposes solutions to remove contamination through a multi-disciplinary lens and case studies from Bangladesh and India. The book may serve as a reference to environment and sustainability researchers, students and policy makers. It delivers an outline to graduate, undergraduate students and researchers, as well as academicians who are working on arsenic toxicity with respect to remediation and health issues.
  • Digital/Print
    Chris Peers, Prem Kumar, Christopher Wyatt, Estelle Gauda, Colin A. Nurse, Nanduri Prabhakar, editors.
    Digital : Springer2015
    Print2015
    Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
  • Digital
    Joseph R. Testa, editor.
    Springer2017
    This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.
  • Digital
    Andrea B. Weir, Margaret Collins, editors.
    Springer2013
    Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
  • Digital
    Chirukandath Gopinath, Vasanthi Mowat.
    Springer2014
    "This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years."--Publisher's website.
  • Digital
    Mahdi Balali-Mood, Mohammad Abdollahi, editors.
    Springer2014
    This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.
  • Digital
    editor, Muzaffer Aksoy.
    TandFonline2017
    Properties, occurrence, and emissions / M. Ikeda -- Analytical techniques / M. Ikeda and T. Okuno -- Experimental benzene toxicity / C.A. Snyder -- Benzene metabolism / K.R. Cooper and R. Snyder -- Benzene hematotoxicity / M. Aksoy -- Benzene carcinogenicity / M. Aksoy.
  • Digital
    edited by Suresh C. Sikka, Wayne J.G. Hellstrom.
    ScienceDirect2017
    Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men's reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health.
  • Digital
    ANSI2003Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-3
  • Digital
    Mahendra Rai, Avinash P. Ingle, Serenella Medici, editors.
    Springer2018
    Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., "Ayurveda". In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma's and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.
  • Digital
    edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush.
    ScienceDirect2017
    Biometals and Alzheimer's disease / Alexandra I. Mot, Peter J. Crouch -- Copper in Alzheimer's disease / Rosanna Squitti, Maricarla Ventriglia, Mariacristina Siotto, Carlo Salustri -- The role of selenium in neurodegenerative diseases / Bárbara R. Cardoso, Dominic J. Hare, Ashley I. Bush -- Does HFE genotype impact macrophage phenotype in disease process and therapeutic response? / Anne M. Nixon, James R. Connor -- Chemical elements and oxidative status in neuroinflammation / Michela Ferraldeschi, Silvia Romano, Maria C. Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria A. Stazi, Alessandro Alimonti, Marco Salvetti, Giovanni Ristori -- Metals and neuroinflammation / Stephen C. Bondy -- Metals and prions / David R. Brown -- Manganese and neurodegeneration / Dinamene Marques Dos Santos, Michael Aschner, Ana P. Marrielha Dos Santos -- Zinc in autism / Stefanie Grabrucker, Andreas M. Grabrucker -- Metals and motor neuron disease / Per M. Roos -- Metals and Lysosomal storage disorders / Henna Kontinnen, Katarína Lejavová, Tarja Malm, Katja M Kanninen -- Developmental exposure to metals and its contribution to age-related neurodegeneration / Lucio G. Costa -- Metal biology associated with Huntington's disease / Terry Jo V. Bichell, Timothy C. Halbesma, K. Grace Tipps, Aaron B. Bowman -- Metal-binding to Amyloid-ss peptide / Melisa Del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller -- Metals and mitochondria in neurodegeneration / Germán Plascencia-Villa, Miguel José- Yacamán, George Perry -- Metal transporters in neurodegeneration / Hong Jiang -- Metal imaging in the brain / David C. Dorman -- Metalloregulation of protein clearance / Alejandra Ramírez Muñoz, Mark A. Greenough, Ashley I. Bush, Carlos M. Opazo -- Metals and autophagy in neurotoxicitiy / Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo -- An overview of multifunctonal metal chelators as potential treatments for neurodegenerative diseases / Frank W. Lewis, David Tétard -- Abnormal function of metalloprotein underlies most neurodegenerative diseases / Katja M. Kanninen, Anthony R. White.
  • Digital
    Aamir Ahmad, editor.
    Springer2019
    ​This volume covers recent progress in breast cancer research. It explores breast cancer, the factors that make it lethal and current research progress, including stem cells, microRNAs, epigenetics, genomics and some novel signaling pathways​.
  • Digital
    Aamir Ahmad, editor.
    Springer2013
    This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed -- source other than Library of Congress.
  • Digital
    Seiichiro Himeno, Keiko Aoshima, editors.
    Springer2019
    This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.
  • Digital
    Tyler J. Curiel, editor.
    Springer2013
    This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • Digital
    Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors.
    Springer2014
    This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Digital/Print
    Digital : IARC2010
    Print2010
    Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
  • Digital
    editor, Curtis D. Klaassen.
    McGraw-Hill eBook Library2013
    Unit I:General Principles of Toxicology -- CHAPTER 1: History and Scope of Toxicology -- CHAPTER 2: Principles of Toxicology -- CHAPTER 3: Mechanisms of Toxicity -- CHAPTER 4: Risk Assessment --Unit II:Disposition of Toxicants -- CHAPTER 5: Absorption, Distribution, and Excretion of Toxicants -- CHAPTER 6: Biotransformation of Xenobiotics -- CHAPTER 7: Toxicokinetics --Unit III:Non-Organ-Directed Toxicity -- CHAPTER 8: Chemical Carcinogenesis -- CHAPTER 9: Genetic Toxicology -- CHAPTER 10: Developmental Toxicology --Unit IV:Target Organ Toxicity -- CHAPTER 11: Toxic Responses of the Blood -- CHAPTER 12: Toxic Responses of the Immune System -- CHAPTER 13: Toxic Responses of the Liver -- CHAPTER 14: Toxic Responses of the Kidney -- CHAPTER 15: Toxic Responses of the Respiratory System -- CHAPTER 16: Toxic Responses of the Nervous System -- CHAPTER 17: Toxic Responses of the Ocular and Visual System -- CHAPTER 18: Toxic Responses of the Heart and Vascular System -- CHAPTER 19: Toxic Responses of the Skin -- CHAPTER 20: Toxic Responses of the Reproductive System -- CHAPTER 21: Toxic Responses of the Endocrine System --Unit V:Toxic Agents -- CHAPTER 22: Toxic Effects of Pesticides -- CHAPTER 23: Toxic Effects of Metals -- CHAPTER 24: Toxic Effects of Solvents and Vapors -- CHAPTER 25: Toxic Effects of Radiation and Radioactive Materials -- CHAPTER 26: Toxic Effects of Plants and Animals -- CHAPTER 27: Toxic Effects of Calories --Unit VI:Environmental Toxicology -- CHAPTER 28: Nanotoxicology -- CHAPTER 29: Air Pollution --Unit VII:Applications of Toxicology -- CHAPTER 30: Ecotoxicology -- CHAPTER 31: Food Toxicology -- CHAPTER 32: Analytical and Forensic Toxicology -- CHAPTER 33: Clinical Toxicology -- CHAPTER 34: Occupational Toxicology -- CHAPTER 35: Regulatory Toxicology.
  • Digital
    Trevor M. Penning, Editor.
    Springer2011
    Historical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
  • Digital
    Cynthia V. Rider, Jane Ellen Simmons, editors ; foreword by Linda S. Birnbaum.
    Springer2018
    Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume--as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book--forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students.
  • Print
    William J. Rea.
    v. 3. Clinical manifestations of pollutant overload -- v. 4. Tools of diagnosis and methods of treatment.
  • Digital
    Keya Chaudhuri, S.N. Chatterjee.
    Springer2009
  • Digital/Print
    Digital : WHO2014
    Print2014
  • Digital
    editors, P. Gopalakrishnakone [and eight others].
    Springer2018
    In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively. -- Provided by publisher.
  • Digital
    edited by Christer Hogstrand and Peter Kille.
    ScienceDirect2008
  • Digital
    edited by Bruce A. Fowler.
    ScienceDirect2013
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
  • Digital
    edited by Orazio Nicolotti.
    Springer2018
  • Digital
    edited by Sean Ekins.
    Wiley2018
    Part I. Computational Methods -- 1. Accessible machine learning approaches for toxicology -- 2. Quantum mechanics approaches in computational toxicology -- Part II. Applying Computers to Toxicology Assessment: Pharmaceutical, Industrial and Clinical -- 3. Computational approaches for predicting hERG activity -- 4. Computational toxicology for traditional Chinese Medicine -- 5. Pharmacophore models for toxicology prediction -- 6. Transporters in hepatotoxicity -- 7. Cheminformatics in a clinical setting -- Part III. Applying Computers to Toxicology Assessment: Environmental and Regulatory Perspectives -- 8. Computational tools for ADMET profiling -- 9. Computational toxicology and reach -- 10. Computational approaches to predicting dermal absorption of complex tropical mixtures -- Part IV. New Technologies for Toxicology, Future Perspectives -- 11. Big data in computational toxicology: challenges and opportunities -- 12. HLA-mediated adverse drug reactions: challenges and opportunities for predictive molecular modeling -- 13. Open science data repository for toxicology -- 14. Developing next generation tools for computational toxicology -- Index.
  • Digital
    edited by Brad Reisfeld, Arthur N. Mayeno.
    Springerv.1 (2012)
    Springerv.2 (2012)
    V. 1. What is computational toxicology? / Brad Reisfeld and Arthur N. Mayeno. Computational toxicology : application in environmental chemicals / Yu-Mei Tan [and others] Role of computational methods in pharmaceutical sciences / Sandhya Kortagere, Markus Lill, and John Kerrigan. Best practices in mathematical modeling / Lisette G. de Pillis and Ami E. Radunskaya. Tools and techniques / Arthur N. Mayeno and Brad Reisfeld. Prediction of physicochemical properties / John C. Dearden. Informing mechanistic toxicology with computational molecular models / Michael R. Goldsmith [and others] Chemical structure representations and applications in computational toxicity / Muthukumarasamy Karthikeyan and Renu Vyas. Accessing and using chemical property databases / Janna Hastings, Zara Josephs, and Christoph Steinbeck. Accessing, using, and creating chemical property databases for computational toxicology modeling / Antony J. Williams [and others] Molecular dynamics / Xiaolin Cheng and Ivaylo Ivanov. Introduction to pharmacokinetics in clinical toxicology / Pavan Vajjah, Geoffrey K. Isbister, and Stephen B. Duffull. Modeling of absorption / Walter S. Woltosz, Michael B. Bolger, and Viera Lukacova. Prediction of pharmacokinetic parameters / A.K. Madan and Harish Dureja. Ligand- and structure-based pregnane X receptor models / Sandhya Kortagere, Matthew D. Krasowski, and Sean Ekins. Non-compartmental analysis / Johan Gabrielsson and Daniel Weiner. Compartmental modeling in the analysis of biological systems / James B. Bassingthwaighte [and others] Physiologically based pharmacokinetic/toxicokinetic modeling / Jerry L. Campbell [and others] Interspecies extrapolation / Elaina M. Kenyon. Population effects and variability / Jean Lou Dorne [and others] Mechanism-based pharmacodynamic modeling / Melanie A. Felmlee, Marilyn E. Morris, and Donald E. Mager -- v. 2. Methods for building QSARs / James Devillers. Accessing and using chemical databases / Nikolai Nikolov [and others] From QSAR to QSIIR : searching for enhanced computational toxicology models / Hao Zhu. Mutagenicity, carcinogenicity, and other end points / Romualdo Benigni [and others] Classification models for safe drug molecules / A.K. Madan, Sanjay Bajaj, and Harish Dureja. QSAR and metabolic assessment tools in the assessment of genotoxicity / Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova. Gene expression networks / Reuben Thomas and Christopher J. Portier. Construction of cell type-specific logic models of signaling networks using CellNOpt / Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez. Regulatory networks / Gilles Bernot, Jean-Paul Comet, and Christine Risso-de Faverney. Computational reconstruction of metabolic networks from KEGG / Tingting Zhou. Biomarkers / Harmony Larson [and others] Biomonitoring-based environmental public health indicators / Andrey I. Egorov, Dafina Dalbokova, and Michal Krzyzanowski. Modeling for regulatory purposes (risk and safety assessment) / Hisham El-Masri. Developmental toxicity prediction / Raghuraman Venkatapathy and Nina Ching Y. Wang. Predictive computational toxicology to support drug safety assessment / Luis G. Valerio Jr. Developing a practical toxicogenomics data analysis system utilizing open-source software / Takehiro Hirai and Naoki Kiyosawa. Systems toxicology from genes to organs / John Jack, John Wambaugh, and Imran Shah. Agent-based models of cellular systems / Nicola Cannata [and others] Linear algebra / Kenneth Kuttler. Ordinary differential equations / Jiří Lebl. On the development and validation of QSAR models / Paola Gramatica. Principal components analysis / Detlef Groth [and others] Partial least squares methods : partial least squares correlation and partial least square regression / Hervé Abdi and Lynne J. Williams. Maximum likelihood / Shuying Yang and Daniela De Angelis. Bayesian inference / Frederic Y. Bois.
  • Digital
    by PK Gupta.
    Springer2019
    This book: "Concepts and Applications in Veterinary Toxicology: An Interactive Guide": covers a broad spectrum of topics related to students specializing in veterinary toxicology and for veterinary medical practitioners. Since the major emphasis of the book is to teach veterinary students, therefore more attention has been given to common toxicants to which several species are exposed including pet animals. The subject of veterinary toxicology is complicated greatly by the wide variations in responses of domestic, companion, aquatic, wild, and zoo species to toxicants. Therefore, emphasis has also been given to species variation and diagnostic toxicology including clinical management that is more relevant to veterinary profession. Key Features - Highlights specialized topics essential for veterinary specialists. - Covers a variety of common toxicants to which several species including pet animals are exposed. - Includes sample questions and answers that are extremely valuable for students, clinical pharmacists, teachers, and academicians in preparing for their board and other examinations.
  • Digital
    edited by C. Dishovsky and A. Pivovarov.
    Springer2009
  • Digital
    edited by Jeffrey Brent, Keith Burkhart, Paul Dargan, Benjamin Hatten, Bruno Megarbane, Robert Palmer, Julian White.
    Springer Live2019-Continuously updated edition
    Building on the previous edition with contributions from internationally renowned experts this book provides a fully comprehensive resource for managing the post emergency/treatment stage of acute poisoning. Chapters incorporate evidence-based paradigms with up-to-date citations from the original medical literature. Topic areas covered include: diagnosis and management of the critically poisoned patient, including pediatric patients and poisoning in pregnancy; toxic syndromes including hepatoxic and pulmonary syndromes as well as poisonings from medications, drugs of abuse, chemical and biological agents. This book is an essential resource for Clinical Toxicologists, Intensivists and Emergency Medicine specialists in training and in practice.
  • Digital
    Maines, Mahin D.
  • Digital
    Archer, Trevor K.; Kostrzewa, Richard M.
    Consists of volumes that cover the latest developments in neurotoxicity studies including neurodegeneration, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.
  • Digital/Print
    Digital : WHO2011
    Print2011
    Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
  • Digital/Print
    Digital : WHO2014
    Print2014
  • Digital
    edited by Mariapia Viola Magni.
    Springer2010
    Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • Digital
    edited by Craig Harris, Jason M. Hansen.
    Springer2012
    In vivo models of developmental toxicology / Jason M. Hansen -- Caenorhabditis elegans as a model in developmental toxicology / Windy A. Boyd, Marjolein V. Smith, and Jonathan H. Freedman -- Zebrafish embryo developmental toxicology assay / Julieta M. Panzica-Kelly, Cindy X. Zhang, and Karen Augustine-Rauch -- Gene knockdown by morpholino-modified oligonucleotides in the Zebrafish (Danio rerio) model : applications for developmental toxicology / Alicia R. Timme-Laragy, Sibel I. Karchner, and Mark E. Hahn -- Amphibian model for studies of developmental reproductive toxicity / Cecilia Berg -- Avian models in teratology and developmental toxicology / Susan M. Smith, George R. Flentke, and Ana Garic -- Overview of in vitro models in developmental toxicology / Craig Harris -- Primary cell and micromass culture in assessing developmental toxicity / M. Pratten -- Embryonic stem cell test : stem cell use in predicting developmental cardiotoxicity and osteotoxicity / Beatrice Kuske, Polina Y. Pulyanina, and Nicole I. zur Nieden -- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay / Marianne Barrier [and others] -- Murine limb bud in culture as an in vitro teratogenicity test System / France-Helene Paradis, Chunwei Huang, and Barbara F. Hales -- Rodent whole embryo culture / Craig Harris -- Rabbit whole embryo culture / Valerie A. Marshall and Edward W. Carney -- Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example / Helen J. Renaud, Allison Rutter, and Louise M. Winn -- Methodological approaches to cytochrome P450 profiling in embryos / Jared V. Goldstone and John J. Stegeman -- Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos / Shao-yu Chen -- Regulation and control of AP-1 binding activity in embryotoxicity / Terence R.S. Ozolins -- Thioredoxin redox status assessment during embryonic development : the redox western / Jason M. Hansen -- Methods for the determination of plasma or tissue glutathione levels / Trent E. Tipple and Lynette K. Rogers -- Oxidative stress, thiols, and redox profiles / Craig Harris and Jason M. Hansen -- Review of toxicogenomic approaches in developmental toxicology / Joshua F. Robinson, Jeroen L.A. Pennings, and Aldert H. Piersma -- Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events / Elena Menegola, Graziella Cappelletti, and Francesca Di Renzo -- DNA methylation screening and analysis / Karilyn E. Sant, Muna S. Nahar, and Dana C. Dolinoy -- Assessment of histiotrophic nutrition using fluorescent probes / Jeffrey Ambroso and Craig Harris -- Diabetic embryopathy / Ulf J. Eriksson and Parri Wentzel -- Gene expression analysis in developing embryos : in situ hybridization / Siew-Ging Gong -- Assessment of gross fetal malformations : the modernized wilson technique and skeletal staining / Robert E. Seegmiller [and others].
  • Digital
    edited by Arnold Schecter.
    Wiley2012
    Persistent organic pollutants : an overview / Daniele Wikoff, Lauren Fitzgerald, Linda Birnbaum Toxic equivalency factors (TEFS) for dioxin and related compounds / Michael DeVito Historic and newer persistent organic pollutants (POPS) in U.S. food / Janice Huwe -- Flame retardants : PBDES and their replacements / Thomas Webster, Heather Stapleton -- Pharmacokinetics of TCDD and related compounds / James Olson -- Immunomodulation by persistent organic pollutants / Robert Luebke [and others] -- Developmental neurotoxicity of dioxins / G. Jean Harry, Pamela J. Lein -- Epidemiological evidence on the health effects of perfluorooctanoic acid (PFOA) / Kyle Steenland, Tony Fletcher, David Savitz -- Polybrominated dibenzo-p-dioxins and dibenzofurans / Kurunthachalam Kannan, Chunyang Liao, Hyo-Bang Moon -- Epidemiological studies on cancer and exposure to dioxin and related compounds / Lennart Hardell, Mikeal Eriksson -- Reproductive and developmental epidemiology of dioxins -- Anne Sweeney [and others] -- Bisphenol A / Thaddeus Shug [and others] -- Phthalates : human exposure and related health effects / John D. Meeker, Kelly K. Ferguson -- The seveso accident / Angela Cecilia Pesatori, Pier Alberto Bertazzi -- Agent orange : long term health and environmental impact in Vietnam / Susan Hammond, Arnold Schecter -- The yusho and yucheng rice oil poisoning incidents / Yoshito Masuda, Arnold Schecter -- The Binghamtom New York electrical transformer fire incident of 1981 / Nancy Kim, Arnold Schecter -- The Yushchenko dioxin poisoning : chronology and pharmacokinetics / John Jake Ryan -- Human health risk assessment of POPS / David Szabo, Anne E. Loccisano.
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation Under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2010
    Print2010
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital
    edited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy.
    Wiley2016
    As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. - Guides researchers as to what drug safety experiments are both practical and useful- Covers a variety of key topics - safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and -omics tools- Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods- Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
  • Digital
    edited by Neil Kaplowitz and Laurie Deleve.
    ScienceDirect2013
    I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
  • Print
    Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
  • Digital
    Frederick "Fritz" T. Fraunfelder and Frederick "Rick" W. Frauenfelder.
    ClinicalKey2021
    National Registry of Drug-Induced Ocular Side Effects -- Ocular drug delivery and toxicology -- Methods for evaluating drug-induced visual side effects -- Anti-infectives -- Drugs affecting the central nervous system -- Drugs affecting the autonomic nervous system -- Analgesics, narcotic antagonists, and drugs used to treat arthritis -- Drugs used in anesthesia -- Gastrointestinal drugs -- Cardiac, vascular, and renal drugs -- Hormones and drugs affecting hormonal mechanisms -- Drugs affecting blood formation and coagulability -- Homeostatic and nutrient drugs -- Drugs used to treat allergic and neuromuscular disorders -- Oncolytic drugs -- Heavy metal antagonists and miscellaneous drugs -- Drugs used in the management of human immunodeficiency virus/acquired immunodeficiency syndrome -- Drugs used in ophthalmology -- Herbal medicine– and dietary supplement–induced ocular side effects.
  • Digital
    Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
    ScienceDirect2015
    Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs' generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation.
  • Digital
    edited by Jean-Charles Gautier.
    Springer2009
    Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
  • Digital
    edited by Jean-Charles Gautier.
    Springer2017
    Nonclinical development of combination drugs / Alberto Lodola -- Juvenile nonclinical safety studies in support of pediatric drug development / Paul C. Barrow and Georg Schmitt -- Procedures of necropsy and tissue sampling / Laurence Fiette, Mohamed Slaoui, and Anne-Laure Bauchet -- Tissue sampling and processing for histopathology evaluation / Mohamed Slaoui, Anne-Laure Bauchet, and Laurence Fiette -- Principles and methods of immunohistochemistry / José A. Ramos-Vara -- Applications of mass spectrometry imaging for safety evaluation / David Bonnel and Jonathan Stauber Part III Genetic Toxicology -- In vivo rat T-lymphocyte Pig-a assay : detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene / Vasily N. Dobrovolsky, Javier Revollo, Dayton M. Petibone, and Robert H. Heflich -- Detection of in vivo mutation in the Pig-a gene of mouse bone marrow erythroids / Takafumi Kimoto and Daishiro Miura -- Use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- Automated patch-clamp methods for the hERG cardiac potassium channel / Sylvie Houtmann, Brigitte Schombert, Camille Sanson, Michel Partiseti, and G. Andrees Bohme -- Impedance measurement in induced pluripotent stem cell-derived cardiomyocytes / Emma-Jane Poulton -- Target safety assessment : strategies and resources / Richard J. Brennan -- NMR and MS methods for metabolomics / Alexander Amberg, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Frank Dieterle, and Matthias Keck -- Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Maha El Hage, and Guy Martin -- Statistical analysis of auantitative RT-PCR results / Richard Khan-Malek and Ying Wang -- Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malésic, and Olivier Gillardeaux -- Evaluation of embryotoxicity using the Zebrafish model / Lisa Truong and Robert L. Tanguay -- Absolute quantification of toxicological biomarkers via mass spectrometry / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington -- Next-generation sequencing to investigate urinary microRNAs from Macaca fascicularis (cynomolgus monkey) / Yaligara Veeranagouda, Jean-François Léonard, Jean-Charles Gautier, and Eric Boitier -- Quantitative RT-PCR for microRNAs in biofluids / Michael Thorsen, Thorarinn Blondal, and Peter Mouritzen -- Chromogenic in situ hybridization methods for microRNA biomarker monitoring of drug safety and efficacy / Barbara R. Gould, Tina Damgaard, and Boye Schnack Nielsen -- Urine exosome isolation and characterization / Jonathan M. Street, Erik H. Koritzinsky, Deonna M. Glispie, and Peter S.T. Yuen.
  • Digital
    edited by Amanda J. Jenkins ; foreword by Yale H. Caplan.
    Springer2008
  • Digital
    Hans-Werner Vohr (ed.).
    Springer2005
  • Digital
    Roger G. Pertwee, editor.
    Springer2015
    There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced ℓ́ℓautoprotectionℓ́ℓ, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose endocannabinoid-induced autoimpairment. This volume describes the physiology, pathophysiology and pharmacology of the endocannabinoid system and potential strategies for targeting this system in the clinic.
  • Digital
    Mary E. Abood, Roger G. Sorensen, Nephi Stella, editors.
    Springer2013
    Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • Digital
    Sushil K. Khetan.
    Wiley2014
    Environmental endocrine disruptors -- Part I. Mechanisms of hormonal action and putative endocrine disruptors. Mechanisms of endocrine system function -- Environmental chemicals targeting estrogen signaling pathways -- Anti-androgenic chemicals -- Thyroid-disrupting chemicals -- Activators of PPAR, RXR, AhR, and steriodogenic factor 1 -- Effects of EDC mixtures -- Environmentally induced epigenetic modifications and transgenerational effects -- -- Part II. Removal mechanisms of EDCs through biotic and abiotic processes. Biodegradations and biotransformations of selected examples of EDCs -- Abiotic degradations / transformations of EDCs through oxidation processes -- -- Part III. Screening and testiing for potential EDCs, implications for water quality sustainability, policy and regulatory issues, and green chemistry principles in the design of safe chemicals and remediation of EDCs. Screening and testing programs for EDCs -- Trace contaminants : implications for water quality sustainability -- Policy and regulatory considerations for EDCs -- Green chemistry principles in the designing and screening for safe chemicals and remediation of EDCs.
  • Digital
    Jose Russo, editor.
    Springer2011
    Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
  • Digital
    Ram Naresh Bharagava, editor.
    Springer2019
    As we know, rapid industrialization is a serious concern in the context of a healthy environment. Various physico-chemical and biological approaches for the removal of toxic pollutants are available, but unfortunately these are not very effective. Biological approaches using microorganisms (bacterial/fungi/algae), green plants or their enzymes to degrade/detoxify environmental contaminants such as endocrine disrupting chemicals, toxic metals, pesticides, dyes, petroleum hydrocarbons and phenolic compounds are eco-friendly and low cost. This book provides a much-needed, comprehensive overview of the various types of contaminants, their toxicological effects on the environment, humans, animals and plants as well as various eco-friendly approaches for their management (degradation/detoxification). As such it is a valuable resource for a wide range of students, scientists and researchers in microbiology, biotechnology, environmental sciences.
  • Digital
    edited by Donna L. Mendrick, William B. Mattes.
    Springer2008
    Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
  • Digital
    Michael D. Coleman.
    Wiley2014
    A brief history of occupational toxicology -- The expert report process in legal context -- Acute toxicity : case histories of solvent exposure -- Chronic and permanent injury : bladder cancer and occupation -- Chronic and acute toxicity of herbicides and pesticides -- Toxicity of imported goods.
  • Digital
    I. Mader, P.R. Fürst-Weger, R.M. Mader, E. Nogler-Semenitz, S. Wassertheurer.
    Springer2010
  • Digital
    edited by Om V. Singh.
    Wiley2017
  • Digital
    Ijeoma F. Uchegbu, Andreas G. Schätzlein, Woei Ping Cheng, Aikaterini Lalatsa, editors.
    Springer2013
    Nanoscience and nanotechnology overview -- Liposome preparation and characterization -- Solid polymeric nanoparticles -- Lipid nanoparticles -- Polymeric vesicles -- Low molecular weight amphiphile micelles -- Polymeric micelles -- Niosomes -- Quantum dots -- Magnetic particles -- Drug nanoparticles -- Polymeric pro-drugs -- Therapeutic Applications of pharmaceutical nanosystems -- Drug solubilisation -- Gene therapy -- Chemotherapy -- Tissue engineering -- Anti-infectives -- Vaccination -- Anti-arthritic drugs -- Imaging agents -- Commercial exploitation of pharmaceutical nanosystems -- Future perspectives -- Multiple Choice -- Problem Sets -- Case Studies -- Suggested Reading.
  • Digital
    Wanda M. Haschek, Brad Bolon, Colin G. Rousseaux, Matthew A. Wallig.
    ScienceDirect2017
  • Digital
    edited by Duarte Miguel F. Prazeresl, Sofia Aires M. Martins.
    Springer2015
    G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins -- Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others] -- Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others] -- Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer -- cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others] -- Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst -- Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith -- Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner -- Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah -- GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas -- Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres -- Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others] -- Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others] -- Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis -- Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others] -- Label-free functional selectivity assays / Ann M. Ferrie [and others] -- Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl -- Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others] -- Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].
  • Digital
    Antoinette Maassen van den Brink, E. Anne MacGregor, editors.
    Springer2019
    This book focuses on the influence of sex and gender in migraine, presenting new insights in basic science as well as their clinical relevance. As migraine is roughly three times more common in women than in men, and also highly depends on hormonal milestones – such as menarche, menstruation, pregnancy and menopause – particular attention is devoted to the role of female sex hormones in this disease. The first chapters present general data on gender-related differences in migraine such as epidemiology, comorbidities and related risks. Furthermore, while several chapters focus on the role of female sex hormones in migraine-triggering mechanisms at a basic scientific level (e.g. cranial circulation), ample attention is also paid to the clinical relevance of such mechanisms and to the best clinical treatment for migraine patients. As the first book entirely devoted to this topic, it will be of interest to researchers and practitioners in the fields of neurology, internal medicine, endocrinology, physiology and pharmacology.
  • Digital
    edited by James M. Parry and Elizabeth M. Parry.
    Springer2012
    The application of structure-activity relationships to the prediction of the mutagenic activity of chemicals / Philip Judson -- Bacterial mutagenicity assays : test methods / David Gatehouse -- The mouse lymphoma assay / Melvyn Lloyd and Darren Kidd -- Mammalian cell HPRT gene mutation assay : test methods / George E. Johnson -- The in vitro mammalian chromosome aberration test / Gill Claire -- The interpretation and analysis of cytogenetic data / Natalie Danford -- The in vitro micronucleus assay / Ann T. Doherty -- The in vitro and in vivo comet assays / Brian Burlinson -- Assessment of DNA interstrand crosslinks using the modified alkaline comet assay / Jian Hong Wu and Nigel J. Jones -- 32P-postlabelling for the sensitive detection of DNA adducts / Nigel J. Jones -- Methods for the detection of DNA adducts / Karen Brown -- The GADD45a-GFP GreenScreen HC assay / Richard M. Walmsley and Matthew Tate -- Real-time reverse-transcription polymerase chain reaction : technical considerations for gene expression analysis / Shareen H. Doak and Zoulikha M. Zaïr -- Cytogenetic in vivo assays in somatic cells / Ann T. Doherty, Adi Baumgartner, and Diana Anderson -- Cytogenetic methods in human biomonitoring : principles and uses / Raluca A. Mateuca, Ilse Decordier, and Micheline Kirsch-Volders -- The measurement of induced genetic change in mammalian germ cells / Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo -- Transgenic animal mutation models : a review of the models and how they function / Steve Dean -- Analysis of genotoxicity data in a regulatory context / Ian de G. Mitchell and David O.F. Skibinski.
  • Digital
    edited by L. María Sierra, Isabel Gaivão.
    Springer2014
    Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
  • Digital
    edited by Alok Dhawan, Mahima Bajpayee.
    Springer2013
    Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
  • Digital
    Jan Willem van der Laan, Joseph J. DeGeorge, editors.
    Springer2013
    The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
  • Digital
    [edited by] Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S. Nelson, Lewis R. Goldfrank ; editor emeritus Neal E. Flomenbaum.
    AccessEmergency Medicine2015
    Pt. A: The general approach to medical toxicology -- Pt. B: The fundamental principles of medical toxicology -- Sect. I: Biochemcial and molecular basis -- Sect. II: Pathophysiologic basis: organ systems -- Sect. III: Special populations -- Pt. C: The clinical basis of medical toxicology -- Sect. I: A: Analgesics and antinflammatory medications -- B: Food, diet, and nutrition -- C: Pharmaceuticals -- D: Antimicrobials -- E: Cardiopulmonary medications -- F: Anesthetics and related medications -- G: Psychotropics -- H: Substances of abuse -- I: Metals -- J: Household products -- K: Pesticides -- L: Natural toxins and envenomations -- M: Occupational and environmental toxins -- N: Disaster preparedness -- Sect. II: Poison centers and epidemiology.
  • Digital
    [edited by] Lewis S. Nelson [and 6 others].
    AccessEmergency Medicine2019
    Historical principles and perspectives -- Toxicologic misfortunes and catastrophes in history -- Initial evaluation of the patient : vital signs and toxic syndromes -- Principles of managing the acutely poisoned or overdosed patient -- Principles of antidote stocking -- Techniques used to prevent gastrointestinal absorption -- Decontamination principles : prevention of dermal, ophthalmic, and inhalational absorption -- Activated charcoal -- Whole-bowel irrigation and other intestinal evacuants -- Principles and techniques applied to enhance elimination -- Laboratory principles -- Principles of diagnostic imaging -- Pharmacokinetic and toxicokinetic principles.
  • Digital
    Denis J. Dupré, Terence E. Hébert, Ralf Jockers, editors.
    Springer2012
    ER-bound steps in the biosynthesis of G protein-coupled receptors / Christian Nanoff and Michael Freissmuth -- Role of chaperones in G Protein coupled receptor signaling complex assembly / Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- GPCR oligomerization: contribution to receptor biogenesis / Kathleen Van Craenenbroeck -- The functional size of GPCRs: monomers, dimers or tetramers? / Darlaine Pétrin and Terence E. Hébert -- Regulation of post-Golgi traffic of G protein-coupled receptors / Guangyu Wu -- Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- Regulatory processes governing the cell surface expression of LH and FSH receptors / Deborah L. Segaloff -- Chaperone-mediated assembly of G protein complexes / Barry M. Willardson and Christopher M. Tracy -- Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / Jane Dingus and John D. Hildebrandt -- Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / Janet D. Robishaw -- G Protein trafficking / Philip B. Wedegaertner -- Differential assembly of GPCR signaling complexes determines signaling specificity / Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- GPCR and voltage-gated calcium channels (VGCC) signaling complexes / Christophe Altier -- Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
  • Digital
    edited by Raymond D. Harbison, Marie M. Bourgeois, and Giffe T. Johnson.
    Wiley2015
  • Digital
    edited by William Slikker, Jr., Merle G. Paule, Cheng Wang.
    ScienceDirect2018
    Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.
  • Digital
    editors, Saura C. Sahu, Daniel A. Casciano.
    Wiley2014
  • Digital
    Lewis S. Nelson, Michael J. Balick.
    Springer2020
    This third edition of the Handbook of Poisonous and Injurious Plants is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. This truly comprehensive resource is botanically rigorous and complete with insights from both pharmacognosy and clinical medicine. With its thorough references and full-color photos of hundreds of potentially toxic and injurious plants inside and outside the home, anyone who has an interest in plants will find this book useful outside in the garden or out in the wild. This book will be of interest to botanists, horticulturists, and naturalists as well as hikers, gardeners, and all those who simply enjoy the wonders of nature and the great outdoors.
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2009
  • Digital
    edited by Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon, Ricardo Ochoa ; Beth W. Mahler (illustrations editor).
    ScienceDirect2013
    ClinicalKey2013
  • Digital
    edited by Robert I. Krieger.
    ScienceDirectv. 1-2, 2010
    The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.

Access restricted to Stanford community

Lane Library Bookmarklet

Lane Library Bookmarklet

To Install, Drag This Button to your Browser Bookmarks or Tools Bar.

What is it?

Lane Library Bookmarklet

Bookmark on Other Websites

Bookmark on Lane

  • To Install, Right Click this Button.
  • Select "Add to Favorites" (click “Continue” if you see a security alert)
  • From the "Create in" menu, select “Favorites Bar” (IE8, IE9) to install
  • Once installed it will look like this
  • Click "Bookmark on Lane" to bookmark any webpage
  • Your saved bookmark will appear on this page
To Install, Right Click this Button.

What is it?

Beyond Stanford

Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available. DynaMed is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS. Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties. Provides critical assessments of systematic reviews compiled from a variety of medical journals. Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions. PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians. Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients. A continually updating drug monograph.ECRI Guidelines Trust: A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or products LPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staff Micromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class. LPCH / Stanford Hospital Formulary. A goldmine of trusted consumer health information from the world's largest medical library. A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs. Provides patient handouts from the American Academy of Family Physician. Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users. Vast collection of software and database programming titles from multiple publishers, including Microsoft Press. Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering. Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources. Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals. Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present. A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.