Books by Subject


  • Digital
    edited by Sara Thorne and Sarah Bowater.
    Oxford Medicine Online2017
    Part 1. Introduction to adult congenital heart disease -- Part 2. Specific lesions -- Part 3. General management issues of adult congenital heart disease.
  • Digital
    Aimin Liu, editor.
    Intro -- Preface -- Contents -- 1: A History of Mouse Genetics: From Fancy Mice to Mutations in Every Gene -- 1.1 Overview -- 1.2 Establishing the Mouse as a Mammalian Model for Research -- 1.2.1 Mendelian Genetics in Mice -- 1.2.2 Inbred Mouse Strains -- 1.3 Getting to Know the Mouse Genome: From Inbred Lines to Genetic Maps -- 1.3.1 Inbred and Congenic Strains -- 1.3.2 The Origins of Developmental Genetics -- 1.3.3 Linkage Analysis, Complementation Tests, and Recombination Maps -- 1.3.4 Cytogenetics: Chromosomal Maps and Rearrangements 1.3.5 Improving Linkage Maps: New Markers, Recombinant Inbred Lines, and Interspecific Backcrosses -- 1.3.6 From Linkage Maps to Physical Maps -- 1.4 The Molecular Biology Revolution and Mouse Genetics -- 1.5 Manipulating the Mouse Genome: Making Mutants -- 1.5.1 The Power of Mutagens -- 1.5.2 Transgenesis: Introducing Exogenous DNA in the Mouse Genome -- 1.5.3 Targeted Mutagenesis Through Homologous Recombination -- 1.5.4 Genome Engineering with Endonucleases: CRISPR/Cas9 Engineering -- 1.6 The Mouse Genome Sequence 1.7 A Mutant in Every Gene: Large-Scale Approaches to Study Gene Function -- 1.7.1 Forward Mutagenesis Screens and Positional Cloning -- 1.7.2 Gene-Trap Mutagenesis Screens -- 1.7.3 The International Knockout and Phenotyping Consortia -- 1.8 Future Perspectives -- References -- 2: Mouse Models of Neural Tube Defects -- 2.1 Overview -- 2.2 Types of NTDs -- 2.3 Diagnosis and Treatment of NTDs -- 2.4 The Etiology of NTDs -- 2.5 NTDs Result from Failure of Neural Tube Closure -- 2.6 Mouse Models Have Been Instrumental in Elucidating the Mechanics of Neural Tube Closure 2.7 Convergent Extension Movements and the Planar Cell Polarity Pathway -- 2.8 Hinge Point Formation -- 2.9 Apical Constriction Is Coordinated with PCP Activation in the Neural Plate -- 2.10 Formation of Hinge Points Is Regulated by Shh and BMPs -- 2.11 PCP, Ciliogenesis, and Shh Signaling -- 2.12 Role of the Nonneural Ectoderm in Neural Fold Elevation and Fusion -- 2.13 Prevention of NTDs by Micronutrient Supplementation -- 2.14 Mechanisms by Which Folic Acid Prevents NTDs -- 2.15 Folate is a Cofactor Required for Synthesis of DNA, Amino Acid and Methyl Donors 2.16 Folate and Homocysteine -- 2.17 Studies in Mice Suggest Supplementation with Inositol or Formate May Prevent Folate-Resistant NTDs -- 2.18 Future Directions -- References -- 3: Animal Models of Pancreas Development, Developmental Disorders, and Disease -- 3.1 Overview -- 3.2 Introduction -- 3.2.1 Overview of Pancreas Development -- 3.2.2 Molecular Regulation of Pancreas Development -- 3.2.3 Developmental Defects and Their Impact on Pancreatic Function and Disease -- 3.3 Juvenile and Adult Diseases of the Pancreas -- 3.3.1 Type 1 Diabetes Mellitus (T1DM) 3.3.2 Type 2 Diabetes Mellitus (T2DM)
  • Digital
    editor Peter P. Karpawich.
    Future Med2015
    Adult congenital heart disease -- Cardiac resynchronization therapy for the univentricular heart -- Ventricular tachycardia in patients with teratology of Fallot -- The role of the implantable cardioverter-defibrillator for primary prevention in the adult with congenital heart disease -- Implantable cardiac device therapy in congenital heart disease -- Heart transplantation in adult congenital heart disease: who? -- Heart transplantation in adult congenital heart disease: when and why not? -- Ask the experts: arrhythmia and hemodynamics -- Multiple choice questions: answers.
  • Digital
    edited by Bidyut Kumar, MD, FRCOG, Consultant Obstetrician and Gynaecologist, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham, North Wales, Honorary Lecturer, Cardiff University, and Honorary Senior Lecturer, Bangor University, Gwyneddn Wales, UK, Zarko Alfirevic, MD, FRCOG, Professor of Fetal and Internal Medicine and Head of Department of Women's and Children's Health at University of Liverpool and Honorary Consultant Obstretician at Liverpool Women's Hospital, UK.
    Section 1. Genetics and antenatal screening -- Section 2. Embryology, fetal physiology and fetal anatomy -- Section 3. Fetal anomalies -- Section 4. Fetal disease -- Section 5. Termination of pregnancy -- Section 6. Fetal growth and wellbeing -- Section 7. Multiple pregnancy -- Section 8. Placenta, amniotic membrane and amniotic fluid -- Section 9. Diagnostic and therapeutic invasive procedures -- Index.
  • Digital
    Bengt Källén.
    This book is the combination of the literature on maternal drug use and birth defects with a set of new data on most types of drugs. In this book, for each group of drugs the relevant scientific literature on drug teratogenicity is presented, with consideration of possible sources of error and also what the findings may mean from a practical point of view. The book also adds data from the Swedish health registers for 1996-2013 based on more than 1.7 million early-pregnancy midwife interviews. Maternal Drug Use and Infant Congenital Malformations will find an engaged audience among people working within the field, and will be of interest to healthcare providers, especially obstetricians and other clinicians who treat women of childbearing age. -- Provided by publisher.
  • Digital
    Richard M. Kostrzewa, Trevor Archer, editors.
    From the contents: Preface -- ADHD Modeling by Perinatal Insult in Animals -- Perinatal Insults to Model Human Neuro-Psychiatric Disorders -- Selective Life-long Destructive of Brain Monoaminergic Nerves -- NGF in Perinatal Development -- Life-long Susceptibility Consequent to Perinatal Substances of Abuse -- Schizotypic Effects of Perinatal Insults.
  • Digital
    Kenneth Lyons Jones, MD., Professor of Pediatrics, Chief, Division of Dysmorphology and Teratology, University of California, San Diego, School of Medicine, La Jolla, California, Marilyn C. Jones, Professor of clinical Pediatrics, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California, Clinical Service Chief, Division of Genetics, Rady Children's Hospital, San Diego, California, Miguel Del Campo, Assistant Professor, Ciècias Experimentals i de la Salut, Universitat Pompeu Fabra, Consultant in Clinical Genetics, Programa de Medicina Molecular i Genètica, Hospital Vall d'Hebron, Barcelona, Spain.
    This medical reference book provides you with complete and authoritative, yet accessible guidance to help accurately diagnose these human disorders, establish prognoses, and provide appropriate management and genetic counseling. Recognize the visual signs of each environmental and genetic abnormality by consulting more than 1,500 full-color photographs and illustrations, many from the personal collections of Drs. Smith and Jones. Find all the answers you need about normal and abnormal morphogenesis, minor anomalies and their relevance, clinical approaches to specific diagnoses, and normal standards of measurement for the entire spectrum of human malformation syndromes. Efficiently identify genetic disorders in your patients with the inclusion of nearly 20 recently recognized entities/syndromes, as well as new chapters on Microdeletions and Microduplication Syndromes.
  • Digital
    edited by Paul C. Barrow.
    ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.
  • Digital
    edited by Luís Félix.
    This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.

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