Books

Contents:
Renal physiology / Kate Bramham and Tracy Salter
Pre-pregnancy counselling and risk assessment / Matt Hall and Liz Lightstone
Contraception / Kate Wiles
Assisted reproduction in women with renal disease / Jason Waugh and Ian Aird
CKD and pregnancy : patterns of care and general principles of management / Lucy Mackillop and Mark Brown
Midwifery issues / Floria Cheng
Drugs in women with renal disease and transplant recipients in pregnancy / Graham Lipkin and Asif Sarwar
Management of hypertension in renal disease in pregnancy / Jenny Myers and Graham Lipkin
Postpartum follow-up of antenatally identified renal problems / Al Ferraro and Liz Lightstone
Pregnancy and dialysis / Kainat Shahid, Liam Plant and Michele Hladunewich
Pregnancy and the renal transplant recipient / Nadia Sarween, Martin Drage and Sue Carr
Comorbid conditions affecting pregnancy in renal transplant patients / Sue Carr and Joyce Popoola
Reflux nephropathy in pregnancy / Nigel Brunskill
Lupus and vasculitis in pregnancy / Liz Lightstone
Diabetic nephropathy in pregnancy / Andrew McCarthy
Urological problems in pregnancy / Jonathon Olsburgh and Susan Willis
Acute renal failure in pregnancy : causes not due to pre-eclampsia / David Williams
Pre-eclampsia related renal impairment / Louise Kenny
Renal biopsy in pregnancy / Nigel Brunskill
Consensus statements 2017.

Summary: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Summary: Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.

Contents:
Introduction to Renal Neoplasms and Clinical Relevance
Normal Kidney
Benign Renal Epithelial and Mesenchymal Neoplasms and their Mimics
Renal Cell Carcinoma: Occurrence and Classification
Urothelial Carcinoma and the Variants
Other Malignant Neoplasms of the Kidney Including Metastatic Lesions.

Contents:
Overview of renal physiology
Regulation of salt and water balance
Disorders of water balance: hyponatremia, hypernatremia, and polyria
Edematous conditions and the use of diuretics
Acid-base physiology and metabolic alkalosis
Metabolic acidosis
Disorders of potassium balance
Urinalysis and approach to the patient with renal dysfunction
Pathogenesis of major glomerular and vascular diseases
Tubulointerstitial diseases
Acute kidney injury
Signs and symptoms of chronic renal failure
Progression of chronic kidney disease.

Summary: This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design. New color photomicrographs of clinical conditions. Additional end-of-chapter summaries. Up-to-date information based on new medical findings.

Contents:
Review of renal physiology
Regulation of salt and water balance
Disorders of water balance: hyponatremia, hypernatremia, and polyuria
Edematous states and the use of diuretics
Acid-base physiology and metabolic alkalosis
Metabolic acidosis
Disorders of potassium balance
Urinalysis and approach to the patient with renal disease
Pathogenesis of major glomerular and vascular diseases
Tubulointerstitial diseases
Acute renal failure
Progression of chronic renal failure
Signs and symptoms of chronic renal failure.

Summary: "Renal pathophysiology can be a difficult subject even for the most advanced medical students. This Fifth Edition of Renal Pathophysiology: The Essentials provides an easy-to-read, case-based approach to learning the mechanisms of renal disease. Each chapter focuses on a mechanism of kidney disease and includes an opening case, learning objectives, integrated open-ended questions, and chapter-ending summaries. Updated with the latest clinical advances and research, this edition also features full-color illustrations and photomicrographs, suggested readings, and online and in-book Q&As"--Provided by publisher.

Contents:
Review of renal physiology
Regulation of salt and water balance
Disorders of water balance: hyponatremia, hypernatremia, polyuria
Edematous conditions and the use of diuretics
Acid-base physiology and metabolic alkalosis
Metabolic acidosis
Disorders of potassium balance
Urinalysis and approach to the patient with renal disease
Pathogenesis of major glomerular and vascular diseases
Tubulointerstitial diseases
Acute kidney injury
Signs and symptoms of chronic renal failure
Progression of chronic kidney disease

Summary: To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally eliminated medications. This updated edition captures nearly 200 new drugs that have been approved by the FDA since the initial publication of Renal Pharmacotherapy. It also covers new evidence that has emerged regarding the need to adjust dosage of certain older medications that are eliminated by the kidneys. Additionally, it presents new data that are being continuously derived in the areas of patient-specific dose individualization for drugs of all types. Comprehensive, convenient, and evidence-based, this reference closes several identified knowledge gaps and will continue to be the leading collection of dosage recommendations for patients with compromised kidney function.

Contents:
A: Acamprosate to Aztreonam
B: Bacitracin to Butorphanol
: Capecitabine to Cycloserine
D: Dabigatran to Dyphylline
E: Edetate Calcium Disodium to Exenatide
F: Famciclovir to Fosfomycin
H: Hetastarch to Hydroxyurea
I: Ibandronate to Itraconazole
K: Kanamycin to Ketorolac
L: Lacosamide to Lurasidone
M: Magnesium Citrate to Mycophenolate Mofetil
N: Nabumetone to Norfloxacin
O: Ofloxacin to Oxcarbazepine
P: Paliperidone to Pyridostigmine
Q: Quinapril to Quinine
R: Ramipril to Ruxolitinib
S: Salsalate to Sunitinib
T: Tadalafil to Trospium
V: Valacyclovir to Voriconazole
Z: Zalcitabine to Zonisamide
Proprietary Name Index.

Summary: "Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book"--Publisher's description.

Contents:
Physiology of body fluids
Structure and function of the kidneys
Glomerular filtration and renal blood flow
Renal transport mechanisms : NaCl and water reabsorption along the nephron
Regulation of body fluid osmolality : regulation of water balance
Regulation of extracellular fluid volume and NaCl balance
Regulation of potassium balance
Regulation of acid-base balance
Regulation of calcium and phosphate homeostasis
Physiology of diuretic action
Integrative case studies
Normal laboratory values
Nephron function
Answers to self-study problems
Answers to integrative case studies
Review examination
Answers to review examination.

Summary: This book is a compilation of scientific knowledge regarding the clinical entity known as "Renal Tubular Acidosis in Children." It contains the information needed to comprehend the intricate mechanisms of acid-base metabolism, electrolyte imbalance, and complications related to renal tubular acidosis in the pediatric age group, since the acid-base physiology and the clinical disorders associated with it in children are quite different from the adult counterpart. The chapters, written by authors, experts in the field, describe systemic and renal physiology, electrolyte alterations, as well as the pathogenesis and chromosomal mutations leading to the development of RTA. The reader will find the latest information on diagnostic tools and learn how to approach diagnosis, avoiding improper treatment, rickets, nephrocalcinosis, and renal failure. In addition, new insights on classification, the clinical presentation of each type of RTA, molecular biology, and transmembrane protein transporters are covered. This work is primarily directed at pediatric nephrologists and pediatricians. Nevertheless, general practitioners, medical students, residents and fellows at different medical training programs, and other health care professionals of nutrition, growth and development, gastroenterology and endocrinology may surely benefit from it.

Contents:
Systemic Regulation of Acid-Base Metabolism
Renal Regulation of Acid-Base Metabolism
Physiology of Renal Potassium Handling
Genetic Origins of Renal Tubular Acidosis
History of Renal Tubular Acidosis
Classification of Renal Tubular Acidosis
Laboratory Diagnosis of Renal Tubular Acidosis
Proximal Renal Tubular Acidosis (Type II)
Distal Renal Tubular Acidosis (Type 1 DRTA)
Hyperkalemia Renal Tubular Acidosis ( RTA Type IV)
Renal Tubular Acidosis due to Miscellaneous Etiology.

Summary: This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.

Contents:
Epidemiology of Renal Tumours of Childhood
Genetic Predisposition to Wilms Tumour
Clinical Presentation
Pathology
Treatment of Wilms Tumor in the Children?s Oncology Group
Treatment of Wilms Tumor ? The SIOP approach
Treatment of Relapsed Wilms Tumor
Imaging
Biological prognostic pathways
Molecular Targeted Therapy for Pediatric Renal Tumors
Surgical Consideration For Wilms Tumours and other Neoplastic Renal Lesions
Radiotherapy for Wilms' Tumour and other Childhood Renal Cancers
Late effects and QOL
Non-Wilms Pediatrci Renal Tumors
Wilms Tumor in Low Income Countries.

Summary: This book describes the recent advances in the understanding of the development and management of renal vascular disease (RVD). Current perspectives regarding the epidemiology of atherosclerotic RVD, its clinical manifestations, and the interaction with injury pathways related to the kidney have evolved considerably, and the widespread introduction of non-invasive methods for identification of RVD using ultrasound, CT, and MR imaging has allowed more facile identification of these diseases than ever before. Renal Vascular Disease provides an accessible, up-to-date summary of the pathophysiology and management of RVD. The clinical paradigms that are emerging in the field, both in regards to RVD and its role in chronic kidney disease (CKD), cardiovascular risk, and the cardiorenal syndromes are discussed in this comprehensive text, making it an essential resource for clinicians and investigators who tackle the challenges of RVD.

Summary: "The goal of this workbook is to change the way clients respond to their emotions when they occur. They will be asked to approach their emotions in a more accepting manner instead of viewing them as something to avoid. Leaning in toward our emotions and responding more effectively to them may be difficult at first, but it will gradually make our emotions more manageable. This introductory chapter describes the types of problems this treatment program (Renfrew Unified Treatment for Eating Disorders and Co-occurring Emotional Disorders) was designed to address. The chapter also explains how eating disorders and other emotional disorders occur together"-- Provided by publisher.

Summary: "The Renfrew Unified Treatment for Eating Disorders and Co-occurring Emotional Disorders is an integrative, transdiagnostic, principle-based approach to address patterns of emotional avoidance, emotion sensitivity, and negative affect that produce and maintain the symptoms of eating disorders and co-occurring emotional disorders. The Renfrew Unified Treatment Model (UT) was developed through an extensive process of adapting the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for use with patients with severe and diverse eating disorders. The modules of the UT are distinct from other approaches due to their cohesive (internal and collective) focus on how each module addresses these shared maintaining mechanisms. There is extensive evidence that eating disorders typically co-occur with other emotional disorders. There is also extensive evidence that eating disorders and other emotional disorders share common maintaining mechanisms, reflecting aspects of emotional functioning"-- Provided by publisher.

Contents:
PREPARING FOR TREATMENT
MODULE 1 MOTIVATION AND GOALS
MODULE 2 UNDERSTANDING EMOTION
MODULE 3 MINDFUL EMOTION AWARENESS
MODULE 4 COGNITIVE FLEXIBILITY
MODULE 5 BEHAVIORAL FLEXIBILITY
MODULE 6 CONFRONTING PHYSICAL SENSATIONS
MODULE 7 EMOTION EXPOSURES
RELAPSE PREVENTION
Appendix A
Appendix B.

Summary: Outside of randomized experiments, association does not imply causation, and yet there is nothing defective about our knowledge that smoking causes lung cancer, a conclusion reached in the absence of randomized experimentation with humans. How is that possible? If observed associations do not identify causal effects in observational studies, how can a sequence of such associations become decisive? Two or more associations may each be susceptible to unmeasured biases, yet not susceptible to the same biases. An observational study has two evidence factors if it provides two comparisons susceptible to different biases that may be combined as if from independent studies of different data by different investigators, despite using the same data twice. If the two factors concur, then they may exhibit greater insensitivity to unmeasured biases than either factor exhibits on its own. Replication and Evidence Factors in Observational Studies includes four parts: A concise introduction to causal inference, making the book self-contained; Practical examples of evidence factors from the health and social sciences with analyses in R; The theory of evidence factors; and Study design with evidence factors. A companion R package evident is available from CRAN.

Contents:

v. 1. Results of the initial evaluation phase.

Contents:
v. 1. Executive summary
v. 2. Crosscutting issues in minority health
v. 3. Cancer
v. 4. Cardiovascular and cerebrovascular disease 2 v.
v. 5. Homicide, suicide, and unintentional injuries
v. 6. Infant mortality and low birthweight
v. 7. Chemical dependency and diabetes
v. 8. Hispanic health issues/Inventory of DHHS programs/Survey of non-federal community.

Summary: This book eases the task of converting research work into a manuscript, and covers the recent developments in publishing that often stump budding researchers. Few researchers in the biomedical sciences are trained in the essential skills of reporting their results, and they seek help in writing a paper that will be acceptable for publication in the 'right' journal, and in presenting their results 'effectively' at a meeting. As well as covering the basic aspects of preparing manuscripts for publication, the book discusses best practices and issues relating to the publication of biomedical research, including topics such as peer-review, authorship, plagiarism, conflicts of interest, publication misconduct, electronic publishing and open-access journals. With more than two decades of experience in conducting workshops on writing scientific papers, the editors have brought together the expertise of 29 authors from seven countries to produce this one-stop guide to publishing research in biomedical sciences. This book is intended for young researchers who are beginning their careers and wish to hone their skills and understand the rigors of research writing and publishing.

Contents:
I. Reports of the Special Committee upon the manufacture, biological testing, and clinical administration of salvarsan and of its substitutes
II. Toxic effects following the employment of arsenobenzol preparations.

Summary: This book summarizes the contributions at an April 2016 conference held at Albany Medical College, Reproductive Ethics: New Challenges and Conversations. Reproductive ethics does not suffer from a lack of challenging issues, yet a few "hot button" issues such as abortion and surrogacy seem to attract most of the attention, while other issues and dilemmas remain relatively underdeveloped in bioethics literature. The goal of this book is to explore and expand the range of topics addressed in reproductive ethics. This is a multi-disciplinary book bringing together philosophers, clinicians, sociologists, anthropologists, and other scholars whose research or clinical interests touch reproductive issues. The results of this compilation are a comprehensive and unique discussion of the evolving issues in the rapidly changing field. The majority of the popular reproductive ethics anthologies were published at least 10 years ago. The field of reproductive ethics would benefit from a new anthology that addresses some of the perennial dilemmas in reproductive ethics (e.g. abortion, sex selection) from updated perspectives and that also covers new technologies that have emerged only in the last few years, such as social egg freezing.

Contents:
Introduction by Lisa Campo-Engelstein and Paul Burcher
Part 1: Genetic Testing and Enhancement
2. Zooming out: Solidarity in the Moral Imagination of Genetic Counseling by Jazmine Gabriel
3. Enhancing Future Children: How It Might Happen, Whether It Should by Susan B. Levin
4. The Decision to Know: Pregnancy and Epistemic Harm by Kirsten M. Kringle-Baer
Part2: Fertility Preservation
5. Egg Freezing and the Feminist Quest for Equality in the Workplace by Karey Harwood
6. Fertility Preservation in Transgender and Gender Nonconforming Youth and Adolescents by Steph deNormand
Part 3:Childbirth
7. Rights and Realities in US Maternity Care by Hermine Hayes-Klein
8. The Periviable Cesarean Section: Can a Case Be Made for Expanding Beneficence in Decision-Making? by Tara A. Lynch and Paul Burcher
Part 3:Abortion, Surrogacy and Circumcision
9."Teaching Morality by Teaching Science:" Religiosity and Abortion Regret by Alesha Doan and J. Shoshanna Ehrlich
10. My Child, Your Womb, Our Contract: The Failure of Contract Law to Protect Parties in Gestational Surrogacy by Claire Horner
11. Vulvar Nick and Metzitzah B'Peh: Punishment or Harm Reduction? by Allan J. Jacobs and Kavita Shah Arora.

Summary: This book is the second collection of essays on reproductive ethics from Drs. Campo-Engelstein and Burcher. This volume is unique in that it is both timely and includes several essays on new technologies, while also being a comprehensive review of most of the major questions in the field, from racial disparities in reproductive healthcare to gene editing and the possibility of the creation of a transhuman species. The scholars writing these essays are pre-eminent in their fields, and their backgrounds are quite varied, including philosophers, anthropologists, physicians, and professors of law. Reproductive ethics remains an underdeveloped area of bioethics despite the recent technological breakthroughs that carry both great promise and potential threats. Building on the first volume of work from a conference held just over one year ago, this new collection of essays from a conference held April 2017 continues this discussion as well as provides ethical insights and reviews of these emerging technologies. The ethical questions swirling around human reproduction are both old and new, but the conference presentations, and the essays derived from them, focus on new ways of appreciating old arguments such as the ethics of abortion, as well as new ways of seeing new technologies such as CRISPR and mitochondrial transfer.

Summary: Black women have higher rates of premature birth than other women in America. This cannot be simply explained by economic factors, with poorer women lacking resources or access to care. Even professional, middle-class black women are at a much higher risk of premature birth than low-income white women in the United States. Dána-Ain Davis looks into this phenomenon, placing racial differences in birth outcomes into a historical context, revealing that ideas about reproduction and race today have been influenced by the legacy of ideas which developed during the era of slavery. While poor and low-income black women are often the "mascots" of premature birth outcomes, this book focuses on professional black women, who are just as likely to give birth prematurely. Drawing on an impressive array of interviews with nearly fifty mothers, fathers, neonatologists, nurses, midwives, and reproductive justice advocates, Dána-Ain Davis argues that events leading up to an infant's arrival in a neonatal intensive care unit (NICU), and the parents' experiences while they are in the NICU, reveal subtle but pernicious forms of racism that confound the perceived class dynamics that are frequently understood to be a central factor of premature birth. The book argues not only that medical racism persists and must be considered when examining adverse outcomes--as well as upsetting experiences for parents--but also that NICUs and life-saving technologies should not be the only strategies for improving the outcomes for black pregnant women and their babies. Davis makes the case for other avenues, such as community-based birthing projects, doulas, and midwives, that support women during pregnancy and labor are just as important and effective in avoiding premature births and mortality. -- Provided by publisher.

Contents:
Part I. Premature predicaments
Into the NICU
Pregnancy and prematurity in the afterlife of slavery
Witnessing a birth: an interlude
Part II. Saving the babies
Narrowing the gap of black women's burden
Radical black birth workers.

Summary: This first volume of the series of the International Academy of Human Reproduction focuses on new aspects of reproductive medicine, from the professional responsibility model of ethics to the areas of high clinical involvement in human reproduction, such as endometriosis, polycystic ovary, family planning and post-coital contraception. The book discusses fertility and assisted reproductive techniques in the context of genetics and epigenetics as well as psychosomatic and longevity aspects. In addition, it presents new technologies and therapeutic strategies to improve IVF results and prevent ovarian hyperstimulation syndrome, as well the new challenges and the future of imaging in reproduction. Menopause and the effects of estrogens on atero-prevention, mood, and more generally the reproductive hormones impact on dementia and healthy aging are also covered. Further, it includes a section devoted to innovative aspects of gynecological surgery, discussing the treatments of vaginal aplasia, reproductive microsurgery and technological breakthroughs in pelvic organ prolapse surgery. Last, but not least, it examines the syndromic aspects of preterm birth. This volume is a useful and comprehensive tool for gynecologists, obstetricians, endocrinologists and all specialists who deal with women's reproductive health.

Summary: An authoritative account of the causes of infertility that fully explores the clinical assessment of patients and covers the decision-making behind treatment options. The content follows the MRCOG syllabus as well as delving deeper into subjects covered by the RCOG Advanced Training Skills Modules (ATSMs), leaving readers well prepared for their examinations. Written by nationally recognised leaders in the field, this volume concisely reviews contemporary clinical practice. Using an aetiology-based approach, chapters discuss ovulatory dysfunction, endometriosis, male infertility, uterine/tubal factors and unexplained infertility. The increasing use of third-party reproduction and surrogacy is explored, along with the psychosocial aspects of this type of treatment. Ethical dilemmas surrounding reproductive medicine and their management are covered in depth. With an emphasis on practical approaches to the delivery and organisation of clinical and laboratory services, readers learn how to ensure the support and care they offer is of the highest quality.

Contents:
Intro; Foreword; Contents;
Chapter 1: Reproductive Science as an Essential Component of Conservation Biology: New Edition; 1 Introduction; 2 Survival and Adaptation of Species in a Changing Environment; 3 Progress in Understanding, Assisting, or Suppressing Reproduction in Wild Species; 4 Concluding Remarks; References; Part I: Survival and Adaptation of Species in a Changing Environment;
Chapter 2: The Importance of Reproduction for the Conservation of Slow-Growing Animal Populations; 1 Introduction; 1.1 The Inherent Flaw of Conventional Sensitivity Analyses 1.2 The Interpretation of Conventional Sensitivity Analyses2 Case Studies; 2.1 Birds; 2.1.1 Case Study: Marbled Murrelet; 2.1.2 Other Bird Studies; 2.2 Ungulates; 2.2.1 Case Study: Bighorn Sheep; 2.3 Carnivores; 2.3.1 Case Study: American Black Bear; 2.4 Cetaceans; 2.4.1 Case Study: Indo-Pacific Bottlenose Dolphin; 3 Conclusion and Future Directions; References;
Chapter 3: Reproductive Impact of Environmental Chemicals on Animals; 1 Introduction; 1.1 Wildlife Exposure and Endocrine Disruption; 1.2 Mode of Action; 2 Occurrence, Fate and Reproductive Toxicity; 2.1 Natural Sex Hormones 2.2 Synthetic Sex Hormones2.3 Pharmaceuticals and Personal Care Products (PPCP); 2.4 Phthalates and Bisphenol-A; 2.5 Pesticides; 3 Reproductive Effects on Wildlife; 3.1 Effects in Fish; 3.2 Effects in Invertebrates; 3.3 Effects in Amphibians; 3.4 Effects in Mammals; 3.5 Effects in Reptiles; 4 Conclusion and Priorities for the Future; References;
Chapter 4: Transgenerational Impact of Environmental Change; 1 Introduction; 2 Defining Transgenerational Programming; 3 State of the Art: Developmental Origins of Health and Disease (DOHaD); 3.1 Human Observational Studies; 3.2 Animal Model Studies 4 Sensitivity of Parental Gametes and Embryos5 Epigenetic Mechanisms; 6 Priorities for the Future; References;
Chapter 5: Stress, Well-Being and Reproductive Success; 1 Introduction; 2 Stress and Reproduction; 2.1 The Neuroendocrine Stress Response; 2.2 How Stress Can Disrupt Reproduction; 2.3 The Role of Glucocorticoids in Normal Reproductive Function; 2.4 Measuring the Stress Response in Wildlife; 3 Alternative Methods to Assess Welfare; 3.1 The Autonomic Nervous System; 3.2 Neuroendocrine; 3.3 Immune Function; 3.4 Biomarkers of Positive Affect 4 Multi-Biomarker Measures of Stress and Welfare4.1 Allostasis and Allostatic Load; 4.2 Allostatic Load Theory and Methodology in Animals; 4.3 From Human Research to Animal Welfare; 4.3.1 Disease and Health Biomarkers; 4.3.2 Diet and Nutrition; 4.3.3 Physical Environment; 4.3.4 Social Environment; 4.3.5 Life Events; 4.3.6 Cognitive Function, Temperament and Personality; 4.3.7 Allostatic Load and Reproduction; 5 Conclusions and Future Perspectives; References;
Chapter 6: Physiological Thresholds in the Context of Marine Mammal Conservation; 1 Introduction; 2 State of the Art

Contents:
Part 1. Introduction. Reproductive science as an essential component of conservation biology / William V. Holt, Janine L. Brown, and Pierre Comizzoli
"Mayday mayday mayday", the Millennium Ark is sinking? / Steven L. Monfort
Part 2. The big picture: can species survive and adapt in a changing world? Climate change, extinction risks, and reproduction of terrestrial vertebrates / Cynthia Carey
Impacts of endocrine disrupting chemicals on reproduction in wildlife / Emmelianna Kumar and William V. Holt
The role of genomics in conservation and reproductive sciences / Warren E. Johnson and Klaus Koepfli
The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction / Agustín F. Fernández, Estela García Toraño, Rocío González Urdinguio, Abel Gayo Lana, Ignacio Arnott Fernández, and Mario F. Fraga
The black-footed ferret: on the brink of recovery? / Rachel M. Santymire, Travis M. Livieri, Heather Branvold-Faber, and Paul E. Marinari
Comparative reproductive biology of elephants / Janine L. Brown
The koala (Phascolarctos cinereus): a case study in the development of reproductive technology in a marsupial / Stephen D. Johnston and William V. Holt
Reproduction and advances in reproductive studies in carnivores / Katarina Jewgenow and Nucharin Songsasen
Methods to examine reproductive biology in free-ranging, fully-marine mammals / Janet M. Lanyon and Elizabeth A. Burgess
Amphibian declines in the twenty-first century: why we need assisted reproductive technologies / John Clulow, Vance L. Trudeau, and Andrew J. Kouba
The reality, use and potential for cryopreservation of coral reefs / Mary Hagedorn and Rebecca Spindler
Recent advances and prospects in germplasm preservation of rare and endangered species / Pierre Comizzoli and William V. Holt
Sperm DNA fragmentation and its role in wildlife conservation / Jaime Gosálvez, William V. Holt, and Stephen D. Johnston
Somatic cells, stem cells, and induced pluripotent stem cells: how do they now contribute to conservation? / Gabriela F. Mastromonaco, L. Antonio González-Grajales, Melissa Filice, and Pierre Comizzoli
Biosafety in embryos and semen cryopreservation, storage, management and transport / A. Bielanski
Fertility control in wildlife: review of current status, including novel and future technologies / Deborah Garside, Ayman Gebril, Manal Alsaadi, and Valerie A. Ferro
Cloning the mammoth: a complicated task or just a dream? / Pasqualino Loi, Joseph Saragusty, and Grazyna Ptak
Conclusions: environmental change, wildlife conservation and reproduction / William V. Holt, Janine L. Brown, and Pierre Comizzoli
Index.

Summary: This well-illustrated, user-friendly text offers a succinct overview of complex surgical sparing management of reproductive pelvic disorders, designed for the reproductive endocrinology and infertility specialist and general gynecologist. World-renowned experts in these areas have contributed detailed chapters that will bolster the surgical knowledge of challenging clinical reproductive infertility scenarios requiring laparoscopic and hysteroscopic skills to enhance fertility outcomes. Providing an understanding of when minimally invasive reproductive surgery is indicated, this book presents clinical pearls to help manage specific pathologies and strategies for managing and minimizing the risks of complications in operative laparoscopy and hysteroscopy. It does so by reviewing pelvic and retroperitoneal anatomy and how it applies to myomectomy, extensive endometriosis, ovarian-tubal surgery, septum, C/S scar isthmocele, Mullerian uterine and vaginal anomalies, and managing complications including bladder and bowel injury. Additionally, selected chapters include accompanying video segments for real-world demonstration of techniques. Reproductive endocrine infertility specialists, as well as clinicians of obstetrics and gynecology interested in reproductive endocrinology and infertility, will find Reproductive Surgery a valuable and focused resource.

Contents:
Correction of Obstructed Hemivagina
Surgical Techniques for Vaginal Agenesis with and without a Functioning Uterus
Overcoming the Challenging Cervix
Correction of Uterine Septum and Roberts Uterus
Intrauterine Adhesions
Intraoperative Management of FIGO Type 2B Fibroids
Proximal Tubal Obstruction
Diagnosis and Surgical Management of Adenomyosis
Hydrosalpinges: Repair or Excise
C/S Scar Repair
Fertility Enhancing Ovarian Cystectomies
Transposition of Ovaries
Imaging Modalities to Pre-operatively Detect Fibroid Location
Detecting and Removing Intraoperative Fibroids You Cannot See
Cervical Fibroids
Uterine Resection of Extensive Adenomyosis
Uterine Transposition
Repair of Bladder Injury
Retroperitoneal Dissection
Deep Infiltrating Endometriosis and Fertility Sparing Techniques
Crisis Management
Mitigating Legal Risk
Egg Retrieval Complications
Reproductive Surgery in Austere Settings.

Summary: "The Society for Reproductive Surgeons (SRS) is one of the few societies in the world dedicated solely to female and male reproductive surgery. It is therefore fitting that SRS write the comprehensive manual for modern surgical procedures for treating female and male infertility. All contributing authors are SRS members and are highly recognized authorities in their respective areas of expertise. It is our intention that this book illustrates the benefits of reproductive surgery, as well as how to perform these procedures using the latest advances, so practitioners can offer their patients all of the current treatment options in this competitive field"--Provided by publisher.

Contents:
Machine generated contents note: 1. Hysteroscopy: office and operative
myomectomy, polypectomy, adhesiolysis Keith B. Isaacson and Christina Salazar; 2. Adhesions in reproductive surgery: treatment and prevention Kathryn D. Coyne and Steven R. Lindheim; 3. Mullerian anomalies Samantha M. Pfeifer; 4. Ovarian surgery with focus on reproduction Samantha M. Pfeifer, Nigel Pereira, Ronald O. Perelman and Claudia Cohen; 5. Surgical management of proximal and distal tubal disease Linnea R. Goodman and Jeffrey M. Goldberg; 6. Tubal anastomosis for reversal of tubal ligation Jeffrey M. Goldberg and Julian A. Gingold; 7. Surgical management of ectopic pregnancy Bala Bhagavath; 8. Surgical management of uterine myomas John C. Petrozza; 9. Laparoscopic surgery for the management of endometriosis Vadim Morozov, Nisha Lakhi and Ceana H. Nezhat; 10. Female fertility preservation surgery Sara Arian, Rebecca Flyckt and Tommaso Falcone; 11. The role of robotics in reproductive surgery Antonio R. Gargiulo; 12. Vasectomy reversal Daniel Greene and Edmund Sabengh; 13. Varicocele repair Christopher M. Deibert, Brooke A. Harnisch and Jay Ira Sandlow; 14. Surgical sperm retrieval methods Phil V. Bach and Peter N. Schlegel; 15. Surgical management of ejaculatory duct obstruction for male infertility Peter T. K. Chan; 16. Fertility considerations in scrotal surgery Katherine Rotker and Mark Sigman.

Summary: This evidence-based book examines the role of reproductive surgery in the current age of IVF and in modern medical practice. The authors provide a detailed insight into surgical techniques and where such practices stand relative to other fertility treatments such as assisted conception techniques. Reproductive Surgery in Assisted Conception is a useful reference book for current practicing reproductive surgeons as well as those training in the field. It is also invaluable to other fertility practitioners wishing to gain more insight into how and when surgical intervention may be used as either a standalone fertility treatment or to improve success rates of other fertility treatments.

Contents:
Part I. Tubal Factor Unfertility
1. Distal Tubal Disease
2. Proximal Tubal Disease
Part II. Endometriosis
3. Endometriosis and Infertility
4. Endometrioma and Infertility: Principles and Techniques of Management
5. The Impact of Endometrioma and its Surgical Treatment on Ovarian Reserve and Reproductive Performance
Part III. The Ovary.- 6. Laparoscopic Ovarian Drilling
7. Ovarian Tissue Cryopreservation
Part IV. Uterine Fibroids
8. Fibroids and Infertility: Principles and Techniques of Management
9. Submucous Fibroids and Infertility
10. The Management of Intramural Fibroids in Women with Infertility
11. Abdominal Myomectomy
12. Principles and Techniques of Laparoscopic Myomectomy
13. Infertility and Uterine Artery Embolisation
Part V. Obesity and Reproductive Surgery
14. Laparoscopy in the Obese Patient
15. Bariatric Surgery
Part VI. Adhesions
16. Adhesions: Effects on Fertility and Pervention
17. Prevention of Intrauterine Adhesions
Part VII. The Uterine Cavity and Endometrium
18. Uterine Anomalies
19. Principles of Hysteroscopic Surgery
20. Uterine Septum
21. Endometrial Polyps and Infertility
22. Local Endometrial Trauma: A Treatment Strategy to Improve Implantation Rates
Part VIII. Surgical Management of Male Infertility
23. Surgical Management of Male Infertility.

Summary: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.

Contents:
Front Matter
Copyright
Contributors
Preface
Introduction: Human Genome Projects: The Omics Starting Point
Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going?
Genetic Variations and Male Infertility
New Genetic Point Mutations in Male Infertility
Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices
Telomeres in Germ Line and Early Embryo: An Overview
Human Protamine Genes' Polymorphisms as a Possible Cause Underlying Male Infertility
Small RNAs Present in Semen and Their Role in Reproduction
Altered Transcriptomic Profiles Associated With Male Infertility
Proteomics and Metabolomics Studies and Clinical Outcomes
Epigenetics, Spermatogenesis, and Male Infertility
Changes in DNA Methylation Related to Male Infertility
Noninvasive Methods of Embryo Selection
Genetic Selection of the Human Embryos: From FISH to NGS, Past and Future
Unraveling the Causes of Failed Fertilization After Intracytoplasmic Sperm Injection Due to Oocyte Activation Deficiency
The Molecular Signature of the Endometrial Receptivity: Research and Clinical Application
The Acquisition of the Human Endometrial Receptivity Phenotype: Lessons From Proteomic Studies
Stem Cell-Derived Spermatozoa
Computational Approaches in Reproductomics
Conclusions--Year 2020: The “-Omics” Technologies and Personalized Assisted Reproduction
Index

Summary: It has become increasingly accepted that important digital data must be retained and shared in order to preserve and promote knowledge, advance research in and across all disciplines of scholarly endeavor, and maximize the return on investment of public funds. To meet this challenge, colleges and universities are adding data services to existing infrastructures by drawing on the expertise of information professionals who are already involved in the acquisition, management and preservation of data in their daily jobs. Data services include planning and implementing good data management practices, thereby increasing researchers' ability to compete for grant funding and ensuring that data collections with continuing value are preserved for reuse. This volume provides a framework to guide information professionals in academic libraries, presses, and data centers through the process of managing research data from the planning stages through the life of a grant project and beyond. It illustrates principles of good practice with use-case examples and illuminates promising data service models through case studies of innovative, successful projects and collaborations.

Contents:
1. The policy and institutional framework / James L. Mullins
2. Data governance : where technology and policy collide / MacKenzie Smith
3. The use of life cycle models in developing and supporting data services / Jake Carlson
4. Data management assessment and planning tools / Andrew Sallans and Sherry Lake
5. Trustworthy data repositories : the value and benefits of auditing and certification / Bernard R. Reilly, Jr., and Marie E. Waltz
6. Copyright, open data, and the availability-usability gap : challenges, opportunities, and approaches for libraries / Melissa Levine
6. Metadata services / Jenn Riley
8. Data citation : principles and practice / Jan Brase ... [et al.]
9. Assimilating digital repositories into the active research process / Tyler Walters
10. Partnering to curate and archive social science data / Jared Lyle, George Alter, and Ann Green
11. Managing and archiving research data : local repository and cloud-based practices / Michele Kimpton and Carol Minton Morris
12. Chronopolis repository services / David Minor, Brian E.C. Schottlaender, and Ardys Kozbial
13. Evaluating a complex project : DataOne / Suzie Allard
14. What to measure? : toward metrics for research data management / Angus Whyte ... [et al.]
15. An institutional perspective on data curation services : a view from Cornell University / Gail Steinhart
16. Purdue University Research Repository : collaborations in data management / D. Scott Brandt
17. Data curation for the humanities : perspectives from Rice University / Geneva Henry
18. Developing data management services for researchers at the University of Oregon / Brian Westra
19. The next generation of challenges in the curation of scholarly data / Clifford Lynch.

Summary: "This best-selling text pioneered the comparison of qualitative, quantitative, and mixed method research design. For all three approaches, John W. Creswell and new co-author J. David Creswell include a preliminary consideration of philosophical assumptions, key elements of the research process, a review of the literature, an assessment of the use of theory in research applications, and reflections about the importance of writing and ethics in scholarly inquiry. The Fifth Edition includes more coverage of: epistemological and ontological positioning in relation to the research question and chosen methodology; case study, PAR, visual and online methods in qualitative research; qualitative and quantitative data analysis software; and in quantitative methods more on power analysis to determine sample size, and more coverage of experimental and survey designs; and updated with the latest thinking and research in mixed methods." -- Provided by publisher

Contents:
Part I: Preliminary considerations
The selection of a research approach
Review of the literature
The use of theory
Writing strategies and ethical considerations
Part II: Designing research
The introduction
The purpose statement
Research questions and hypotheses
Quantitative methods
Qualitative methods
Mixed method procedures.

Summary: Soil and water salinity is a major challenge for the agricultural community and policy makers in terms of meeting the burgeoning populations demand for food and other agricultural commodities. In coastal regions, climate change and sea level rise will aggravate the problem with more and more areas becoming saline due to intrusion of sea water. As such there is a pressing need for modern tools and innovative techniques for the identification of salty soils and poor-quality waters, crop production, soil reclamation and lowering the water table in waterlogged areas. Tackling next-generation problems such as contamination of soil and underground water due to fluoride and arsenic, as well as developing multi-stress tolerant crops is also a high priority. Further, techniques for domesticating halophytes, mangrove-based aquacultures, using seaweed cultures as agricultural crops and integrated farming systems need to be perfected. This book addresses all these aspects in detail, highlighting the diverse solutions to tackle the complex problem of salinity and waterlogging and safer management of poor-quality waters. With chapters written by leading experts, it is a valuable resource for researchers planning future investigations, policy makers, farmers and other stakeholders, and for students wanting insights into vital issues of environment.

Contents:
Part 1. Introduction, History and Perspectives
Chapter 1. Historical perspectives and dynamics of nature, extent, classification and management of salt-affected soils and waters
Chapter 2. A brief review on soil salinity mapping by optical and radar remote sensing
Chapter 3. Synergy between Sentinel-MSI and Landsat-OLI to support high temporal frequency for soil salinity monitoring in an arid landscape
Chapter 4. Modern technologies for diagnosis and prognosis of salt-affected soils and poor-quality waters
Part 2. Drivers, Stressors and Indicators
Chapter 5. Salinity tolerance indicator
Chapter 6. Soil-plant-microbes interactions in salt-affected soils
Chapter 7. Salt tolerant microbes in mangroves: ecological role and bioprospecting potential
Chapter 8. The current understanding of mangrove forests of India
Part 3. Salinization Mechanisms and Impacts
Chapter 9. Causes and management of root-zone salinity and sodicity in the arid west Texas: field scale experience
Chapter 10. Salinity induced physiological and molecular responses of halophytes
Chapter 11. Characterization and problems of saline-sodic Vertisols and their management options
Chapter 12. Carbon dynamics in salt-affected soils
Chapter 13. Engineered polymeric and nano-materials for taming salty soils and waters used for crop production
Chapter 14. Potential pollutants in soil system: impacts and remediation
Chapter 15. Groundwater pollution through different contaminants: Indian scenario
Chapter 16. Tree-based systems for enhancing environmental services of saline environments
Part 4. Management Opportunities and Strategies
Chapter 17. Identification, evaluation and domestication of alternative crops for saline environments
Chapter 18. Engineering and biological approaches for drainage of irrigated lands in India
Chapter 19. Reclamation of salt-affected soils in drylands of Ethiopia: a review
Chapter 20. Reviving the productivity of sal t-affected lands: Technological options, constraints and research needs
Chapter 21. Coastal saline soils of India: problems, reclamative measures and management strategies
Chapter 22. Agro-interventions for sustainable management of salt-affected Vertisols in India
Chapter 23. Saline agroforestry- a hanging fruit for saline waterlogged ecologies
Chapter 24. Fruit and vegetable-based saline agricultural systems for nutritional and livelihood security
Chapter 25. Integrated farming system approach for managing saline and waterlogged ecologies
Chapter 26. Use of poor-quality waters for agricultural production
Chapter 27. Management of sodic waters in agriculture
Part 5. Impact Assessment, Policies and Socio-economic Issues
Chapter 28. Approaches and methodologies to socio-economic synergies with ecological sciences
Chapter 29. Management of salt-affected soil: Gender and socioeconomic dimensions for sustainable livelihoods
Chapter 30. Autonomous adaptation strategies to multiple stressors: a case study with marginal communities in Eastern Uttar Pradesh, India
Chapter 31. Future research needs: way forward for combating salinity in climate change scenario.

Summary: Research for research sake is no longer tenable or affordable; to be valuable to society, research must have impact! This textbook takes the reader on a journey from how the UK Research Excellence Framework assesses impact to real examples of outstanding research impact case studies. Along the way, Prof. Hugh McKenna describes and explains the case for research impact, the challenges, the link between research impact and evidence informed practice, achieving impact through changing policy and engaging with the public, how researchers can make their research findings more impactful and how research impact is assessment nationally and internationally It is written in an easily accessible and understandable style, with reflective exercises amply distributed throughout its pages and helpful guides helping to engage readers and notably health professionals who are often turned off by the normal heavy research tomes. This book makes the complex simple and the wearisome fascinating. The short chapters are interesting and authoritative and can be read on a 'standalone' basis, allowing readers to 'dip in and out'. From his experience in various countries, the author has a unique insight into what research impact is, how it is assessed and how and where research findings can have the most benefit. The stimulus for this book has been the excellent feedback that the author has received from health professionals, students and fellow researchers. There is always a risk that good knowledge and experience do not transfer well into a good textbook. In Research Impact: Guidance on Advancement, Achievement and Assessment, nothing has been lost in the transition. The book will be of great interest to many health researchers from nursing to midwifery to pharmacy, medicine or any allied health professional, but also to any research manager in all professions who want their research to bring positive change to society, culture, the economy, health and quality of life. It will be of particular interest to those who want to understand the difference between research impacts that are weak and those that are outstanding and how such assessments are made.

Contents:
Chapter 1. Research Impact: the what, why, when and how
Chapter 2. Research Impact: drafting case studies
Chapter 3. Research Impact: How to Prepare and Submit Case Studies
Chapter 4. Research Impact: How Assessors Prepare and Assess
Chapter 5. Research Impact: The Challenges
Chapter 6. Research Impact: Engaging with the Public and Policymakers
Chapter 7. Research Impact: The Link to Evidence Informed Practice
Chapter 8. Research Impact: An Analysis of Approaches in Health Sciences
Chapter 9. Research Impact: A Global Perspective on its Assessment.

Summary: Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

Contents:
Reproducibility in biomedical reseaech / Kevin Mullane, Michael J. Curtis and Michael Williams
Experimental planning and execution / Kevin Mullane, Michael J. Curtis and Michael Williams
Statistical analysis in preclinical biomedical research / Michael J. Marino
Reporting results / Kevin Mullane, Michael J. Curtis and Michael Williams
Addressing reproducibility / Kevin Mullane, Michael J. Curtis and Michael Williams
Biomedical research in the 21st century / Kevin Mullane, Michael J. Curtis and Michael Williams.

Summary: This book offers a detailed update on research into diabetes with onset in childhood or adolescence. The coverage ranges from fundamental aspects such as study design and statistical analysis through to new ideas for research, the latest research findings, and implications of these findings for clinical care in childhood. Examples of topics addressed in this context include the prevention of diabetic complications, management of micro- and macrovascular complications, the roles of nutrition and exercise, insulin therapy, islet transplantation, and risky behaviors in teenagers. Attention is also focused on the latest technologies, including the artificial pancreas and continuous glucose monitoring, and associated regulatory aspects. The reader will find novel insights into the ways in which research is impacting on clinical management as well as advice on methodology and stimulating ideas on future research areas. The book is based on presentations delivered at the 15th ISPAD (International Society for Pediatric and Adolescent Diabetes) Research School for Physicians, held in Milan. It will be of interest for all diabetologists, pediatricians, dietitians, biomedical engineers, nurses, and students.

Contents:
Feeding the planet, energy for the future
PART I: Up-To-Date in Childhood Type 1 Diabetes
Diabetes ketoacidosis management in children and adolescents. ISPAD vs ISPED: similarities and differences
Insulin and immune therapy in children and adolescents with type 1 diabetes
Adolescent prevention of complications
Hvidoere Study Group: What can be learned from observational studies
Long term microvascular complications: new ideas for research
Exercise in children with type 1 diabetes
Nutritional aspects of type 1 diabetes: we need to keep struggling against paleontological dietetic regimens (how research helps us to do the right thing)
Nutrition and insulin resistance during childhood and adolescence
Diminished 1,25-dihydroxyvitamin D with preserved 25-hydroxyvitamin D levels in 10-18 year old youth with new-onset type 1 diabetes
Risky beaviours in teens with type 1 diabetes: new ideas for research regarding a not too studied topic
PART II: The technological route to the future
Glucose sensors
Glucose monitoring and insulin pump therapy in the management of children and adolescents with type 1 diabetes
Advanced pump functions: bolus calculator, bolus types, temporary basal
Regulatory aspects of new technology in diabetes: Can research help us?.

Summary: This practical book is designed for anyone who is planning to undertake a research project in the social sciences for the first time. Organised around eight operational steps, it explains difficult procedures step-by-step.

Contents:
Research: A way of thinking
Research process: a quick glance
Formulating a research problem
Reviewing the literature
Formulating a research problem
Identifying variables
Constructing hypotheses
Step II: Conceptualising a research design
Research design
Selecting a study design
Step III: Constructing an instrument for data collection
Selecting a method of data collection
Collecting data using attitudinal scales
Establishing the validity and reliability of a research instrument
Step IV: Selecting a sample
Selecting a sample
Step V: Writing a research proposal
Step VI: Collecting data
Considering ethical issues in data collection
Step VII: Processing and displaying data
Processing data
Displaying data
Step VIII: Writing a research report.

Summary: "The current book on research methodology is primarily meant for students, scholars and interested faculty members of biomedical sciences like medicine, dentistry, nursing, pharmaceuticals, physiotherapy, etc. Format: The format and content of the book has been kept concise for easy readability, with examples drawn exclusively from real healthcare scenarios for easy understanding, and at the same time without compromising on the basic principles of research methodology. Math Issue for Health Science Students--doesn't and wont be too high level of math. Appropriate level for the health science student Biomedical Ethics, Review of Medical Literature also discusses how to write a dissertation"-- Provided by publisher.

Contents:
Introduction: environmental psychology and its methods / Robert Gifford
Observational methods : the first step in science / Reuven Sussman
Behavioral mapping and tracking / Cheuk Fan Ng
Research designs for environmental issues / Wokje Abrahamse, P. Wesley Schultz and Linda Steg
Agree to disagree : a practical guide to conducting survey research in environmental psychology / Donald W. Hine, Christine Kormos, and Anthony D.G. Marks
Who cares? : measuring environmental attitudes / Amanda McIntyre and Taciano L. Milfont
Qualitative approaches to environment-behavior research : understanding environmental and place experiences, meanings, and actions / David Seamon and Harneet K. Gill
Revealing the conceptual systems of places / David Canter
Behavioral methods for spatial cognition research / Daniel R. Montello
Microworlds: using computers to understand choices about the use of natural resources / Angel Chen and Paul A. Bell
Simulating designed environments / Arthur E Stamps III
Planning the built environment : programming / Jay Farbstein, Richard E. Wener and Lindsay J. McCunn
Did that plan work? : post-occupancy evaluation / Richard E. Wener, Lindsay J. McCunn and Jennifer Senick
Action research: enhancing application / Valeria Cortés and Robert Sommer
Research designs for measuring the effectiveness of interventions / Wokje Abrahamse
Applying behavioral science for environmental sustainability / E. Scott Geller, Wokje Abrahamse, Branda Guan and Reuven Sussman
Improving human functioning : ecotherapy and environmental health approaches / Thomas Doherty and Angel Chen
Research and design for special populations / John Zeisel, Robert Gifford, Mark Martin, and Lindsay J. McCunn
Advanced statistics for environment-behavior research : multilevel modeling and structural equation modeling / Donald W. Hine, Victor Corral-Verdugo, Navjot Bhullar, and Martha Frias-Armenta
Meta-analysis : an analysis of analyses / Christine Kormos.

Contents:
Research and librarianship
Developing the research study
Principles of quantitative methods
Survey research
Experimental research
Analysis of qualitative data
Principles of qualitative methods
Individual interviews
Ethnographic approaches to qualitative research
Analysis of qualitative data
Historical research
Applied research
Writing the research proposal
Written and oral presentation of the research project.

Contents:
Overview of research designs applied to radiology / Andreas Roposch and Andrea S. Doria
Descriptive statistics / Mateen Shaikh and Hadas Moshonov
Statistical methods for analysis of diagnostic tests / George Tomlinson, Gerald Lebovic, Connie Marras, and Andrea S. Doria
Measurement : validity, reliability, responsiveness / Alexandra M. Easson, George Tomlinson, and Andrea S. Doria
Observational designs / Marinka Twilt, Ivan R. Diamond, and Susanne M. Benseler
Randomized controlled trials / Ivan R. Diamond and Brian M. Feldman
Systemic reviews, evidence-based imaging, and knowledge translation / Andrea S. Doria, Jennifer Stinson, and Prakeshkumar Shah
Decision analysis / Ava A. John-Baptiste and Sapna Rawal
Costs and consequences : an introduction to economic evaluation in radiology / Wendy J. Ungar and Richard Zur
Conducting and publishing research / Andrea S. Doria, Peter Strouse, and Thomasin Adams-Webber
Obtaining ethics approval, data management, and budget formulation / Ravi Menezes, Tuula Kalliomäki, and Yasser Karimzad
Steps for using research as a success tool in academia / Aine Kelly and Suresh Mukherji
Introduction to statistical inference : point estimation, confidence intervals, and hypothesis tests / Christopher Meaney, Rahim Moineddin, and George Tomlinson
An introduction to linear and logistic regression / Christopher Meaney, Mateen Sheik, Rahim Moineddin, and Andrea S. Doria
Sample size estimation / Mateen Shaikh, Joseph Beyene, and Andrea S. Doria
Introduction to meta-analysis / Joseph Beyene, Binod Neupane, and Zelalem Firisa.

Summary: This book presents methods for investigating the effects of aquatic environmental changes on organisms and the mechanisms involved. It focuses mainly on photosynthetic organisms, but also provides methods for virus, zooplankton and other animal studies. Also including a comprehensive overview of the current methods in the fields of aquatic physiology, ecology, biochemistry and molecular approaches, including the advantages and disadvantages of each method, the book is a valuable guide for young researchers in marine or aquatic sciences studying the physiological processes associated with chemical and physical environmental changes.

Contents:
Chapter 1 Measurement of environmental parameters affecting marine plankton physiology
Chapter 2 Plankton culture techniques
Chapter 3 Determination of Key Enzymes involved in primary productivity
Chapter 4 Analyses of pigments
Chapter 5 Measurements and analyses of photosynthesis and respiration
Chapter 6 Chlorophyll fluorescence techniques and applications
Chapter 7 Biochemical and molecular methods
Chapter 8 Research methods for animal and virus.

Contents:
Ch. 1. Human subjects research protections
Ch. 2. Investigational new drug and device exemption process
Ch. 3. The institutional animal care and use committee
Ch. 4. Biological hazards and select agents
Ch. 5. Radiological hazards and lasers
Ch. 6. Controlled substances: maintaining institutional compliance
Ch. 7. Export controls and US research universities
Ch. 8. Data management and research integrity
Ch. 9. Intellectual property
Ch. 10. Financial conflicts of interest in research
Ch. 11. Good laboratory practices (GLPs)
Ch. 12. Human embryonic stem cell research oversight: a confluence of voluntary self-regulation and shifting policy initiatives
Index.

Summary: "Resident Readiness: General Surgery prepares you for success during your surgical internship. Inside is a full range of scenarios you may experience during your residency, supported by comprehension questions with detailed answer explanations and tips to help you remember. You will also learn the clinical problem-solving process so you can think quickly on your feet, especially when time is critical. With the book's step-by-step guidance, you will gain the confidence you need to perform at your best on Day One of your residency"-- Provided by publisher.

Summary: Prepares you for success during your internship. This book presents a full range of clinical scenarios you may experience during your residency, supported by comprehension questions with detailed answer explanations and tips to remember.

Contents:
Cover
Title Page
Copyright Page
Dedication
CONTENTS
CONTRIBUTORS
ACKNOWLEDGMENTS
INTRODUCTION
I. Gynecology
1. A 46-year-old G3P3 With Heavy Menstrual Bleeding, Interested in Hysterectomy
2. A 46-year-old Woman Presents With Heavy Menses
3. A 31-year-old Female With Vaginal Bleeding at 6 Weeks Pregnant
4. A 27-year-old With Abdominal Pain and a Positive Pregnancy Test
5. A 21-year-old Female Presents to the Emergency Department With Abdominal/Pelvic Pain
6. A 23-year-old Female With Worsening Painful Periods 7. A 26-year-old Referred for Evaluation of Chronic Pelvic Pain
8. A 31-year-old With a Breast Lump
9. A 50-year-old Woman With Pelvic Pain and an Adnexal Mass
10. A 51-year-old Woman With Hot Flashes, Mood Swings, and Who Is Not Sleeping
11. A 36-year-old Patient Trying to Get Pregnant
12. A 32-year-old Multiparous Patient Desires Laparoscopic Tubal Ligation
13. A 46-year-old Female With Complaints of Leaking Urine
14. A 46-year-old Female With Heavy Menses
15. A 48-year-old Postoperative Patient With Dyspnea
II. Obstetrics 16. A 27-year-old Postpartum Patient Admitted to the Surgical Intensive Care Unit
17. A 25-year-old G3 P0111 Presents for Prenatal Care
18. A 32-year-old Primigravida With a Lagging Fundal Height
19. A 20-year-old With a History of Preterm Birth
20. A 20-year-old G1 P0 at 28 Weeks Gestation Complaining of Leakage of Fluid
21. A 19-year-old Primigravida With Headache and High Blood Pressure
22. A 25-year-old G3 P2002 With Vaginal Bleeding
23. A 19-year-old Presents to Obstetric Triage, 38 Weeks Pregnant With Intermittent Abdominal Pain 24. A 26-year-old Multipara Contracting at Term
25. A 26-year-old G1P0 at 39 Weeks in Need of Induction
26. A Laboring Woman With Recurrent Variable Decelerations
27. A 30-year-old P3003 at 38.2 Weeks With Contractions and Feeling Pressure
28. A 28-year-old G5 P4 Admitted for Elective Repeat Cesarean Delivery
29. An 18-year-old Primigravida Pushing for 3 Hours
30. A 36-year-old Patient With Obstetrical Hemorrhage
31. A Newborn With Decreased Respiratory Effort
32. A 28-year-old G5 P2123 Postoperative Day Number 2 From a Cesarean Delivery 33. A 27-year-old With Fever 1 Day After Cesarean Delivery
34. A 22-year-old With Breast Pain 3 Days After a Vaginal Delivery
35. Perinatal Depression
III. Ambulatory Care
36. A 46-year-old Female Here for a "Checkup"
37. A 24-year-old Woman With Vaginal Discharge
38. A 22-year-old With a 2-day History of Urinary Frequency, Urgency, and Dysuria
39. A 23-year-old Sexually Active Female in Clinic for an Annual Examination
40. A 34-year-old Female Who Desires Oral Contraception
41. A 19-year-old G2P1011 Presents to the Office for Contraception Counseling

Summary: Utilizing a practical, high-yield presentation, this textbook is a comprehensive review of the most common shoulder and elbow diagnoses and management strategies. It allows easy access to pertinent information for residents and fellows while preparing for rounds, the clinic and the operating room and also aides residents studying for their yearly in-training exam (OITE). Each topic is organized in a consistent, bulleted format so that the information flows in a logic manner: history, physical examination, imaging (when and what to order), and the most appropriate treatment algorithm. The most common classification systems are emphasized and illustrated, and treatment algorithms are further organized into non-operative and operative and include surgical approaches as well as the risks and complications of surgical intervention. The shoulder and elbow are covered in their own exclusive sections, with each chapter discussing the unique diagnostic considerations for each anatomic structure and the types of injuries to expect. Topics in the shoulder section include osteoarthritis, rotator cuff arthropathy and tears, instability, stiffness, SLAP tears and biceps tendinitis, and fractures of the clavicle and scapula. Topics in the elbow section include biceps and triceps rupture, lateral and medical epicondylitis, instability and stiffness, and elbow fractures - distal humerus, Monteggia, the terrible triad and more. Case material, key points and takeaways, and question-and-answer elements are included to enhance the text's overall utility. There is currently no textbook on the shoulder and elbow tailored specifically for orthopedic residents, fellows and senior medical students. The Resident's Guide to Shoulder and Elbow Surgery therefore provides a much-needed resource for early-career clinicians and surgeons.

Contents:
Glenohumeral Osteoarthritis
Rotator Cuff Tear Arthropathy
Inflammatory Arthritis
Rotator Cuff Tear
Anterior Shoulder Instability
Posterior Instability
Multidirectional Instability
SLAP Tears and Biceps Tendinopathy
Adhesive Capsulitis
Impingement and Acromioclavicular Arthritis
Proximal Humerus Fractures
Acromioclavicular Joint Injuries
Sternoclavicular Joint Dislocation and Instability
Scapula Fractures
Medial and Lateral Epicondylitis
Elbow Dislocation
Lateral Ulnar Collateral Ligament Injury
Medial Collateral Ligament Tears
Arthritis of the Elbow
Distal Humerus Fractures
Monteggia Fractures
Radial Head Fractures
Terrible Triad of the Elbow
Pediatric Supracondylar Humerus Fracture.

Summary: With an emphasis on set-up and execution and lessons learned from expert practitioners, this concise, practical guide for residents and fellows presents the essentials for both common and complex spine surgery. Proceeding anatomically from the cervical to the sacroiliac, and including chapters on spinal tumors, infection and revision surgery, nearly 40 different procedures are highlighted, from corpectomy, arthroplasty and laminectomy to percutaneous screws, decompression and fusion. Chapters include all the information a resident will need to know: indications and contraindications, imaging and diagnosis, OR set-up and instrumentation selection, the specific operative technique, post-operative protocols, and clinical pearls and pitfalls. Radiographs and full-color intraoperative photographs accompany each procedure. Whether suturing dura or performing a lateral interbody fusion, spinal surgery is a technical pursuit, and having a firm grasp of the details can ultimately determine the procedure's success. Written and edited by veterans in orthopedic surgery and neurosurgery, The Resident's Guide to Spine Surgery is just the detailed, user-friendly resource for up-and-coming clinicians looking to develop and expand their surgical expertise. .

Contents:
ACDF set up and approach and decompression
Cervical Corpectomy
Cervical Arthroplasty
Posterior Cervical Set up
Posterior Cervical Fusion surgery Occiput to C2
Posterior Cervical Laminectomy and Fusion Surgery C3-C7
Cervical Laminoplasty
Posterior cervical discectomy/foraminotomy (MIS)
Thoracic Posterior Instrumentation without scoliosis
Thoracic Posterior Instrumentation with Scoliosis
Anterior Thoracic Decompression and Fusion (Minimally Invasive)
Thoracic corpectomy
Transpedicular thoracic discectomy
Lumbar Microdiscectomy
Far lateral lumbar discectomy (MIS)
Lumbar Open TLIF with screws
Lumbar corpectomy
Lumbar Minimally Invasive TLIF
Lumbar Lateral Interbody Fusion L3-4, L4-5
Lumbar Lateral Interbody Fusion L1-2, L2-3
Lumbar Oblique Interbody Fusion
Anterior Lumbar Interbody Fusion
Anterior Lumbar Disc Replacement
Lateral Lumbar Interbody Fusion for Lumbar Scoliosis
Percutaneous Lumbar Screws
Percutaneous Iliac and S2AI Fixation
Anterior Odontoid Screw tips and Tricks
Navigation in spine surgery
Cerebrospinal fluid leak repair
Sacroiliac Joint fusion
Biologics and Healing of Fusion
Infections (surgical strategies)
Revision Lumbar decompression strategies
Revision pedicle screw strategies
Revision cervical strategies revision surgeries
Metastatic tumor stabilization
Intradural tumor resection
Closed and open reduction techniques for cervical fractures.

Summary: This inspiring book presents ten factors to help anyone become stronger and more resilient to life's challenges.

Contents:
What is resilience?
Optimism: belief in a brighter future
Facing fear: an adaptive response
Moral compass, ethics, and altruism: doing what is right
Religion and spirituality: drawing on faith
Social support: learning the tap code
Role models: providing the road map
Training: physical fitness and strengthening
Brain fitness: challenge your mind and heart
Cognitive and emotional flexibility
Meaning, purpose, and growth
The practice of resilience.

Summary: "These days it's hard to count on the world outside. So it's vital to grow strengths inside like grit, gratitude, and compassion--the key to resilience, and to lasting well-being in a changing world. True resilience is much more than enduring terrible conditions. We need resilience every day to raise a family, work at a job, cope with stress, deal with health problems, navigate issues with others, heal from old pain, and simply keep on going. With his trademark blend of neuroscience, mindfulness, and positive psychology, New York Times bestselling author Dr. Rick Hanson shows you how to develop twelve vital inner strengths hardwired into your own nervous system. Then no matter what life throws at you, you'll be able to feel less stressed, pursue opportunities with confidence, and stay calm and centered in the face of adversity. This practical guide is full of concrete suggestions, experiential practices, personal examples, and insights into the brain. It includes effective ways to interact with others and to repair and deepen important relationships. Warm, encouraging, and down-to-earth, Dr. Hanson's step-by-step approach is grounded in the science of positive neuroplasticity. He explains how to overcome the brain's negativity bias, release painful thoughts and feelings, and replace them with self-compassion, self-worth, joy, and inner peace"--Goodreads.com.

Summary: This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

Contents:
Mechanisms of Glucocorticoid Response and Resistance in Lymphoid Malignancies
Resistance to Monoclonal Antibody Therapeutics in Lymphoma
Resistance to Antibody-Drug Conjugate
Resistance to Proteasome Inhibitor Therapy in Non-Hodgkin Lymphoma
Resistance to Histone Deacetylase Inhibitors in the Treatment of Lymphoma
Resistance to Brutons Tyrosine Kinase Signaling Pathway Targeted Therapies
Resistance to Checkpoint Blockade Inhibitors and Immunomodulatory Drugs
Resistance to Bispecific T-cell Engagers and Bispecific Antibodies
Resistance to Chimeric antigen receptor T-cell therapy
Index.

Summary: This book covers interpretation of visual fields by Humphrey and Octopus perimeters and discussion of Humphrey visual fields in a variety of ocular disorders.It examines dilemmas faced by an ophthalmologist while evaluating visual fields which do not match with the clinical picture. Glaucoma, the commonest condition for visual field investigation is discussed in detail. Logical reasoningfor incorporating perimetry in glaucoma management with a clear understanding of the challenges in its interpretation is delved into. The book progresses to advanced glaucoma and glaucoma progression. It discusses a systematic evaluation of various parts of the visual field so that the reader can make a calculated management plan for their patient. Each chapter attempts to clearly enunciate factors that help in the diagnosis and features which may be confused with other conditions. Fields which help diagnosing early, advanced glaucoma and glaucoma progression with images and methods of ensuring reasonable diagnostic accuracy are included. The book incorporates separate chapters on ocular conditions which also mimic visual field defects of glaucoma with detailed modes of correct diagnosis, diagnostic dilemmas arising from retinal, macular, vascular, visual pathway lesions mimicking visual field defects of glaucoma or while coexisting with glaucoma, supported by algorithms to achieve a quick diagnosis in a busy OPD without missing the clinical findings and by using minimal investigative modalities. This book helps clinicians to prevent over diagnosis or under diagnosis of glaucoma and helps diagnose cases with morbidities causing visual field defects.

Contents:
Intro
Preface
Contents
About the Editors
1: What Is Perimetry and How to Obtain the Best Results?
References
2: Incorporating Perimetry in Managing Glaucoma
2.1 Introduction
2.2 The Role of Perimetry in the Management of Glaucoma is Multifold
2.2.1 To Help in Diagnosis of Glaucoma
2.2.2 Staging the Disease Based on Visual Fields
2.2.3 Detecting and Monitoring Progression
2.3 Limitations of Standard Automated Perimetry (SAP)
2.4 Other Forms of Visual Field Testing
2.5 Conclusion
References 3: Interpretation of a Humphrey Single Visual Field Printout
3.1 Sequence for Interpretation of a Single Field
3.2 Summary
References
4: Challenges in Interpreting Perimetry in Glaucoma
4.1 Introduction
4.1.1 Challenge 1: Is This the Printout of My Patient?
4.1.2 Challenge 2: Why Do I Need the Date of Birth to Be Accurate?
4.1.3 Challenge 3. What Is the Fixation Loss Telling Me?
4.1.4 Challenge 4: What Should I Do with a Field with High False Positives?
4.1.5 Challenge 5: What Is the Interpretation for High False Negative? 4.1.6 Challenge 6: What Can I Pick Up from the Gray Scale?
4.1.7 Challenge 7: If the Total Deviation Plot Is Similar to the Pattern Deviation Plot. What Does it Mean?
4.1.8 Challenge 8: What Do the Probability Symbols Tell us?
4.1.9 Challenge 9: How Much Importance Do I Attach to the GHT?
4.1.10 Challenge 10: How Should the VFI Be Assessed?
4.2 Practical Tips Which Can Help Standardize the Process
4.3 Factors Affecting the Variability of the Visual Field Tests [11]
4.4 Summary
References
5: Evaluating Progression on Perimetry
5.1 Progression 5.2 Patterns of Progression
5.3 Criteria for Progression Are as Follows
5.4 Importance of Finding Out Progression
5.5 The Guided Progression Analysis (GPA) Software on HFA
5.5.1 Event Analysis
5.5.2 Trend Analysis
5.6 Rate of Progression
5.7 The Guided Progression Analysis (GPA
Carl Zeiss Meditec, Inc., Dublin, CA)
5.8 Reading the GPA Printout
5.8.1 First Part
5.8.1.1 Baseline Tests (Fig. 5.1)
5.8.2 Second Part: I
5.8.2.1 Progression Analysis (Fig. 5.2)
5.8.3 Second Part: II
5.8.3.1 Progression Bands (Fig. 5.3)
5.8.4 Third Part 5.8.4.1 Recent Visual Field Report with Progression Analysis (Fig. 5.4)
5.9 Progression Artifacts
5.10 Case 1
5.10.1 OD ONH Color Photo
5.10.2 OS ONH Color Photo
5.10.3 OD GPA
5.10.4 OS GPA
5.11 Case 2
5.11.1 OS ONH Color Photo
5.11.2 OS ONH Red-Free Photo
5.11.3 OS OCT
5.11.4 OS GPA
5.12 Case 3
5.12.1 OD ONH Colour Photo
5.12.2 OD ONH Red-Free Photo
5.12.3 OD GPA
5.13 Case 4
5.13.1 OS ONH Color Photo
5.13.2 OS ONH Red-Free Photo
5.13.3 OS GPA
5.14 Case 5
5.14.1 OD ONH Colour Photo

Summary: What are the ethical issues raised by the increasing use of big data and artificial intelligence in health care? How should physicians respond when they have a conscientious objection to an intervention requested by a patient? How should health care organizations respond to physician requests? How can physicians best help patients make informed decisions about end-of-life and life-sustaining care? How should interns and residents respond to ethical dilemmas created by duty hours restrictions? Resolving Ethical Dilemmas: A Guide for Clinicians helps residents, students, and practitioners work through these and many more common and challenging ethical questions that affect patient care. The 6th Edition reflects important changes in medicine and healthcare policy and provides additional clarity to complex concepts. Offering practical, real-world advice, it helps you think through and resolve difficult cases, prompting thoughtful, well-reasoned answers to the question of “What do I do in this situation?” --Provided by publisher.

Summary: Variability in care in emergency surgery is well known, particularly in abdominal surgery, and reducing it is fundamental to improving outcomes. It is therefore vital to identify the factors that are key to improving mortality and reducing complications in various surgical emergencies. Under the leadership of the World Society of Emergency Surgery, over 200 leading experts in emergency surgery, critical care and surgical infections established a template to help define and optimise emergency surgery, particularly that relating to the abdomen. This book refines this initial work, crystallising it into a meaningful resource for practising surgeons and health care administrators alike, and paving the way for advances in emergency surgery around the globe. This book sets a benchmark for Emergency Surgery and is a must read for those wanting their patients to do better.

Contents:
PART I KEY POSITION TOPICS Chapter 1 Resources and Designation of Emergency Surgery
Chapter 2 Acute Care Surgery Unit Structure
Chapter 3 Optimal Care in Geriatric Emergency Surgery (GES)
Chapter 4 Sepsis: Control and Treatment
Chapter 5 Resuscitation in Emergency General Surgery
Chapter 6 Medical Laboratory Support for Emergency Surgery
Chapter 7 Radiology and Emergency Surgery
Chapter 8 Interaction Between Gastroenterology and Emergency General Surgery
Chapter 9 Advanced and Specialist Nursing Practice in Emergency Surgery
The Team Approach
Chapter 10 Data, Registry, Quality Improvement and Patient Outcome Measures
Chapter 11 Research in Emergency General Surgery
Chapter 12 Education and Training in Emergency Surgery
Chapter 13 Appendicitis
Chapter 14 Acute Mesenteric Ischaemia
Chapter 15 Intra-Abdominal Hypertension and Abdominal Compartment Syndrome
Updates
PART II KEY PERFORMANCE INDICATORS Chapter 16 Cholecystitis
Chapter 17 Pancreatitis
Chapter 18 Upper GI Bleed
Chapter 19 Small Bowel Obstruction
Chapter 20 Perforated Gastroduodenal Ulcer (PGDU)
Chapter 21 Acute Diverticulitis (AD)
Management Phase
Chapter 22 Abdominal Vascular Emergencies
Chapter 23 Coagulation
Chapter 24 Wound Care
Chapter 25 Complications in Emergency General Surgery.

Summary: This book tackles the role of interrelated conditions in the manifestation and course of pulmonary ailments. The articles run the gamut from basic to clinical science on such topics as airway allergy challenges, pulmonary dysfunction due to exposure to environmental pollution, molecular and functional aspects of smoking in lung carcinogenesis and in obstruction-related respiratory disorders, and others. Attention is directed to the developments in rehabilitative and lifestyle interventions in chronic disabilities, particularly involving neuromotor and stress-related conditions which, with advancing age, may lead to the deterioration of ventilation, with hypoxic sequelae. Enhanced research and awareness concerning the lung health drive better treatments and quality of life. Clinical insights presented in the book underscore a major role played by the science in transmuting biomedical knowledge into a better patient management. The volume is addressed to clinicians, researchers, physiotherapists, and other healthcare professionals engaged in effective patient care and therapy.

Summary: The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.

Summary: "This book describes the purpose of patient assessment and then guides the reader through the process of reviewing existing data in the medical record, conducting the patient interview, performing the physical assessment, and finally evaluating the diagnostic studies needed and developing and implementing a respiratory care plan. This text is designed for undergraduate and entry-level graduate courses in respiratory care, applied respiratory physiology, pulmonary disease, and mechanical ventilation (among others). The second edition has been updated to include additional questions related to the National Board for Respiratory Care exam, as well as updated AARC Clinical Practice Guidelines and National Best Practices alongside the text"-- Provided by publisher.

Contents:
Introduction to patient assessment
Development and implementation of respiratory care plans
Review of the medical record
Patient history
Physical assessment
Assessment of oxygenation
Assessment of ventilation
Blood gas analysis, hemoximetry, and acid-base balance
Laboratory studies
Cardiac assessment and the electrocardiogram
Cardiopulmonary imaging
Adult pulmonary function
Bronchoscopy and other diagnostic studies
Acute and critical care monitoring and assessment
Obstructive sleep apnea and other sleep-related breathing disorders
Neonatal and pediatric assessment.

Contents:
The Stress Reaction: a Historical Perspective, O. Rom, and A.Z. Reznick
The Environmental Domain of Quality of Life in Patients with Chronic Respiratory Diseases, D. Kurpas, K. Szwamel, and B. Mroczek
Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0-59 Months, A .Nitsch-Osuch, E. Kuchar, A. Topczewska-Cabanek, K. Wardyn, K. Życińska, and L. Brydak
Antibiotic Prescription Practices among Children with Influenza, A. Nitsch-Osuch, E. Gyrczuk, A. Wardyn, K. Życinska, and L. Brydak
Antigenic Drift of A/H3N2/ Virus and Circulation of Influenza-Like Viruses During the 2014/2015 Influenza Season in Poland, K. Bednarska, E. Hallmann-Szelińska, K. Kondratiuk, and L.B. Brydak
Growing Antibiotic Resistance in Fatal Cases of Staphylococcal Pneumonia in the Elderly, J. Yayan, and K. Rasche
Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis, M. Typiak, K. Rębala, M. Dudziak, J.M. Słomiński, and A. Dubaniewicz
Chronic Cough as a Female Gender Issue, N. Kavalcikova-Bogdanova, T. Buday, W.J. Song, and J. Plevkova
Treatment Options for Central Sleep Apnea: Comparison of Ventilator, Oxygen, and Drug Therapies, J. Yayan, and K. Rasche
The Guinea Pig Sensitized by House Dust Mite: a Model of Experimental Cough Studies, T. Buday, S. Gavliakova, J. Mokry, I. Medvedova, N. Kavalcikova-Bogdanova, and J. Plevkova
Index.

Summary: "Respiratory physiology involves a number of areas, all of which are complex. These areas include the structure and function of the lung, the mechanics of breathing, gas exchange within the lung, oxygen uptake/transport and delivery, control of carbon dioxide and ventilation. Both pathologies of the lung itself as well as other disorders (cardiac disease, neurological disease, haematological disease, musculoskeletal disorders etc) have varying effects on the different aspects of pulmonary physiology. In addition, advanced respiratory treatments such as mechanical ventilation may also have effects on all of these. Respiratory terminology encompasses both anatomical and physiological descriptors, as well as terms used in investigations and respiratory management. For the non-pulmonologist or intensivist, much of this terminology may be confusing. Many of the terms sound similar and may seem to be used interchangeably"-- Provided by publisher.

Contents:
Respiratory Physiology and Terminology / Timothy Crozier
Pulmonary Assessment in Pregnancy / Tabassum Firoz
Approach to Common Respiratory Problems in Pregnancy / Karen Patterson
Cardiopulmonary Physiological Alterations in Pregnancy / Niamh Hayes and Thomas Drew Gas Exchange Across the Placenta / Brahmdeep S. Saini, Janna L. Morrison and Mike Seed
Pulmonary Infections in Pregnancy / Priya Daniel, Timothy Hills and Wei Shen Lim
Asthma in Pregnancy / Danish Ahmad and Erika Yoo
Cystic Fibrosis in Pregnancy / Melanie Chin and D Elizabeth Tullis Restrictive Lung Disease in Pregnancy / Stephen Lapinsky
Pulmonary Thromboembolic Disease in Pregnancy / Wee-Shian Chan Shian Chan
Pulmonary Hypertension in Pregnancy / Liesbeth ten Klooster, Vicki J Wilson, Ruth Newton, Karen Selby, Suarabh V Gandhi and
David G Kiely David G Kiely
Sickle Chest Syndromes in Pregnancy / Ann Kinga Malinowski and Nadine Shehata
Sleep-Disordered Breathing in Pregnancy / Jennifer E Dominguez and Ghada Bourjeily
Acute Respiratory Distress Syndrome and Respiratory Failure in Pregnancy / Justin Seashore and Alexander Duarte Justin Seashore and Alexander Duarte
Other Pulmonary Conditions in Pregnancy / Muhammed Ehtisham, Humnah Khudayar and Patricia Russo-Magno
Dyspnea of Pregnancy / Stephen Lapinsky and Ghada Bourjeily
Amniotic Fluid Embolism Syndrome / Marie Baldisseri
Pregnancy-Associated Pulmonary Edema / Lisa Moore
Smoking in Pregnancy / Catherine Chamberlain
Radiological Imaging of the Chest in Pregnancy / Shital Gandhi and Siobhan Bacon Shital Gandhi and Siobhan Bacon
Respiratory Drug Therapy in Pregnancy / Nika Mehta
Biological and Immunosuppressive Respiratory Therapy in Pregnancy / Bernadette Jenner and Catherine Nelson- Bernadette Jenner and Catherine Nelson-Piercy
Oxygen Therapy in Pregnancy / Daniela Vaquez and Gustavo A. Plotnikow
Airway Management in Pregnancy / Kyle Jespersen and Michaela K. Farber
Mechanical Ventilation in Pregnancy / José Rojas- José Rojas-Suarez and Jezid Miranda

Summary: This book provides a detailed overview of the latest innovations in respiratory endoscopy, from both diagnostic and therapeutic perspectives; each chapter focuses on one disease and the techniques for early diagnosis as well as treatment. It comprehensively covers treatment and procedures, including simultaneous X-ray fluoroscopy and its use during bronchoscopic procedures. This fast-developing technology is essential for the medical management of non-malignant and malignant diseases of the chest, especially lung cancer. Respiratory Endoscopy describes the cooperation between all the members of the healthcare team, and as such is a valuable resource not only for medical staff, but also for radiological technicians and nursing staff who contribute significantly in the care of the patients undergoing these invasive procedures. By promoting teamwork and providing practical know-how, it will improve the success and safety of respiratory endoscopy procedures.

Contents:
Part I Edition for Radiological Technicians
1. The Role of X-ray Fluoroscopy in Bronchoscopy
2. Development of X-ray Fluoroscopy Devices
3. Characteristics of X-ray Fluoroscopy
4. Image Processing of X-ray Fluoroscopy and New Digital Tomography
5. Quality Control in X-ray Fluoroscopy and Digital Tomography
6. Computed Tomography Imaging to Bronchoscopic Navigation
Part II Edition for Doctors
7. Fluorographic and Radiographic Conditions in Bronchoscopy Using X-ray Fluoroscopy
8. Identification of the Involved Bronchus to Peripheral Pulmonary Lesions on Computed Tomography
9. Anesthesia for Bronchoscopy
10. Processing Samples
11. Rapid On-site Cytology Evaluation
12. Type and Selection of Flexible Bronchoscope
13. Latest in Bronchoscopy (Hi-Vision Scope with Rotation Function)
14. Basic Flexible Bronchoscopy
15. Tomography-Guided Transbronchial Biopsy for Peripheral Pulmonary Lesions
16. Radial Endobronchial Ultrasound Findings
17. Radial EBUS Findings for Ground Glass Opacity: Comparison of Radiologic and Pathologic Findings
18. Endobronchial Ultrasound with a Guide Sheath for Peripheral Pulmonary Lesions
19. Transbronchial Needle Aspiration Through a Guide Sheath for Peripheral Pulmonary Lesions
20. Virtual Bronchoscopic Navigation for Peripheral Pulmonary Lesions
21. Virtual Bronchoscopic Simulation by CT Workstation
22. The Dose and Risk Factors for Radiation Exposure from X-ray Fluoroscopy during EBUS-GS for Peripheral Pulmonary Lesions
23. Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
24. Endobronchial Ultrasound Elastography
25. Flex-rigid Pleuroscopy under Local Anesthesia
26. Stent Placement Under X-ray Fluoroscopy
27. Therapeutic Bronchoscopy for Central Airway Obstruction (Balloon, Argon Plasma Coagulation, High Frequency)
28. Endoscopic Bronchial Occlusion With Silicone Spigots
29. Photodynamic Therapy for Lung Cancer
Part III Edition for Nurses
30. Actual Nursing in Respiratory Endoscopy.

Summary: The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.

Contents:
The Influence of Online Health Information on the Attitude and Behavior of People Aged 50+
Socio-Economic Indicators Shaping Quality of Life and Illness Acceptance in Patients with Chronic Obstructive Pulmonary Disease
Field Safety Notes in Product Problems of Medical Devices for Use in Pulmonology
Unmet Needs of Patients with Chronic Respiratory Diseases within Primary Healthcare
Pulmonary Rehabilitation in Advanced Lung Cancer Patients During Chemotherapy: a Randomized Controlled Study
Ondine's curse
genetic and iatrogenic central hypoventilation as diagnostic options in forensic medicine
Pulmonary Function Abnormalities in Regard to Age at the Time of Diagnosis of Hypersensitivity Pneumonitis
Specific Inhalation Challenge in Persulfate Asthma
Inflammatory Activity in Autism Spectrum Disorder
How do Skeletal Muscles Die? An Overview
Index.

Contents:
Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children / Wrotek, T. Jackowska, and K. Pawlik
Detection of respiratory tract pathogens with molecular biology methods / Wozniak-Kosek, J. Kosek, and B. Zielnik-Jurkiewicz
Classical against molecular-genetic methods for susceptibility testing of antituberculotics / I. Porvaznik, J. Mokry, and I. Solovic
Does customer information fulfill MEDDEV criteria in cases of product problems of in vitro diagnostics for infection testing? / Jürgen Hannig and Rüdiger Siekmeier
Sodium and copeptin levels in children with community acquired pneumonia / August Wrotek, Teresa Jackowska, and Katarzyna Pawlik
Etiological factors causing lower respiratory tract infections isolated from hospitalized patients / A. Guzek, Z. Rybicki, K. Korzeniewski, K. Mackiewicz, E. Saks, A. Chciałowski, and E. Zwolińska
Antibiotic consumption pattern in the neonatal special care unit before and after implementation of the hospital's antibiotic policy / Nitsch-Osuch, D. Kurpas, E. Kuchar, K. Życińska, T. Zielonka, and K. Wardyn
Respiratory tract infections in children in primary healthcare in Poland / E. Kuchar, K. Miśkiewicz, L. Szenborn, and D. Kurpas
Impact of updated European consensus guidelines on the management of neonatal respiratory distress syndrome on clinical outcome of preterm infants / S. Smolarova, L. Kocvarova, K. Matasova, M. Zibolen, and A. Calkovska
Index.

Contents:
Molecular characteristics of influenza virus Type B lineages circulating in Poland / K. Bednarska, E. Hallmann-Szelińska, K. Kondratiuk, D. Rabczenko, and L.B. Brydak
Obstructive sleep apnea is realted to increased arterial stiffness in ultrasound speckle-tracking analysis / I. Tuleta, D. Skowasch, J. Krycki, C. Pizarro, C. Hammerstingl, M. Weber, N. Schahab, G. Nickenig, C. Schaefer, and S. Pingel
Sclerostin in obstructive sleep apnea / M. Kosacka, I. Porębska, and A. Brzecka
Atherosclerotic vessel changes in sarcoidosis / I. Tuleta, S. Pingel, L. Biener, C. Pizarro, C. Hammerstingl, C. Öztürk, N. Schahab, C. Grohé, G. Nickenig, C. Schaefer, and D. Skowasch
Asthma and COPD: similarities and differences in the pathophysiology, diagnosis and therapy / Josef Yayan and Kurt Rasche
Intracellular and extracellular cytokines in A549 cells and THP1 cells exposed to cigarette smoke / A. Holownia, P. Wielgat, E. Rysiak, and J.J. Braszko
Frequency of rare Alpha-1 antitrypsin variants in Polish patients with chronic respiratory disorders / K. Duk, A. Zdral, B. Szumna, A. Roży, and J. Chorostowska-Wynimko
Influence of body shape composition on respiratory function in adult women / Z. Czapla, A. John, A. Szwed, T. Hané, M. Durda, J. Ratajczak, and E. Barłóg
Concurrent validity and reliability of a new balance scale used in older adults / Oz Zur, Tamar Shaki, and Eli Carmeli
Quality of care for patients with chronic respiratory diseases: data for accreditation plan in primary healthcare / Donata Kurpas, Katarzyna Szwamel, and Bożena Mroczek
Index.

Summary: This book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays remains the cornerstone in life saving in critically ill patients with and without respiratory failure. However, conclusive evidences show that mechanical ventilation can also cause lung damage, specifically, in terms of ventilator-induced lung injury. Respiratory monitoring encloses a series of physiological and pathophysiological measurements, from basic gas exchange and ventilator wave forms to more sophisticated diaphragm function and lung volume assessments. The progress of respiratory monitoring has always been accompanied by advances in technology. However, how to properly conduct the procedures and correctly interpret the data requires clear definition. The book introduces respiratory monitoring techniques and data analysis, including gas exchange, respiratory mechanics, thoracic imaging, lung volume measurement, and extra-vascular lung water measurement in the initial part. How to interpret the acquired and derived parameters and to illustrate their clinical applications is presented thoroughly. In the following part, the applications of respiratory monitoring in specific diseases and conditions is introduced, including acute respiratory distress syndrome, obstructive pulmonary diseases, patient-ventilator asynchrony, non-invasive ventilation, brain injury with increased intracranial pressure, ventilator-induced diaphragm dysfunction, and weaning from mechanical ventilation. This book is intended primarily for ICU physicians and other practitioners including respiratory therapists, ICU nurses and trainees who come into contact with patients under mechanical ventilation. This book also provides guidance for clinical researchers who take part in respiratory and mechanical ventilation researches.

Contents:
Gas exchange
Respiratory mechanics
Lung imaging
Lung volume measurement
Extravascular lung water monitoring
Acute respiratory distress syndrome
Obstructive pulmonary diseases
Patient-ventilator asynchrony
Non-invasive ventilation
Brain injury with increased intracranial pressure
Ventilator-induced diaphragm dysfunction
Weaning from mechanical ventilation.

Summary: This book presents pulmonary outcomes of prematurity, from their emergence in infancy through to their consequences in adulthood. With an increasing number of preterm births and more infants surviving, there is now a larger population of adults with lung disease originating in infancy requiring specialized care. Looking at the whole group of preterm infants, not just those with bronchopulmonary dysplasia, this text covers a wide spectrum of pulmonary outcomes, including: pulmonary hypertension, wheezing, and alterations in sleep. The chapter authors focus on critically appraising what is and is not known about each outcome and suggest key questions that still need to be answered. Respiratory Outcomes in Preterm Infants: Sequelae from Infancy through Adulthood is an ideal reference for the multidisciplinary group that cares for these preterm infants and the adults they become, including: neonatologists, pediatric pulmonologists, pediatricians, adult pulmonologists, primary care physicians, nurses, and fellows.

Contents:
The problem of the preterm lung: definitions, history, and epidemiology
Why do preterm infants wheeze? Clues from epidemiology
Why do former preterm infants wheeze? Clues from the laboratory
The bronchopulmonary dysplasia diagnosis: definitions, utility, limitations
Structural and functional changes in the preterm lung
Diagnostic modalities: pulmonary function testing and imaging
Longer term sequelae of prematurity: the adolescent and young adult
Adverse outcomes do not stop at discharge: post-NICU health care use by prematurely born infants
Opportunities to promote primary prevention of post neonatal intensive care unit respiratory morbidity in the premature infant
Sleep outcomes in children born prematurely
Airway outcomes
Pulmonary hypertension in bronchopulmonary dysplasia
Infection and inflammation: catalysts of pulmonary morbidity in bronchopulmonary dysplasia.

Summary: "Gain a foundational understanding of respiratory physiology and how the respiratory system functions in health and disease. Respiratory Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book"--Publisher's description.

Contents:
Overview of the respiratory system: function and structure
Mechanical properties of the lung and chest wall
Dynamic lung mechanics
Tests of lung function
Alveolar ventilation
The pulmonary circulation
Ventilation (V̇), perfusion (Q̇) & their relationships
Oxygen and carbon dioxide transport
Pulmonary aspects of acid-base balance and arterial blood gas interpretation
Control of respiration
Non-respiratory functions of the lung
The lung under special circumstances
Appendices. Answers to self-study problems
Multiple-choice examination.

Summary: Both communicable and noncommunicable diseases of the respiratory system are an increasing healthcare problem despite medical advances. This book aims at unraveling the mechanisms and improving the treatment of pulmonary pathologies, ranging from such common conditions like influenza and related viral infections, functional lung dysfunction, to lung lesions and others. Chapters present late-breaking findings in the diagnostics, pharmacotherapy, and clinical evidence-based decision-making to provide results that can be used to improve healthcare and quality of life. Extending new knowledge and exploring recent medical advances, the book will hopefully help enrich research and clinical experience regarding important respiratory issues. The book is intended for general practitioners and all professionals engaged in the pulmonary field, from basic scientists to clinical investigators.

Contents:
Impaired Vascular Function in Sarcoidosis Patients
Effectiveness of Bronchofiberoscopy in Diagnosis of Lung Lesions
Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome
Public Perception of the Risks Associated with Infectious Diseases in Poland: Ebola and Influenza and Their Impact on the Attitude to Vaccination
The Sentinel System as the Main Influenza Surveillance Tool
The activity of influenza and influenza-like viruses in individuals aged over 14 in the 2015/16 influenza season in Poland
Clinical utility of Berlin Questionnaire in Comparison to Polysomnography in Patients with Obstructive Sleep Apnea
Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression
Stress Response, Brain Noradrenergic System and Cognition
Small Airway Obstruction in Chronic Obstructive Pulmonary Disease: Potential Parameters for Early Detection.-index. .

Summary: This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.

Contents:
Reactive oxygen species, granulocytes, and NETosis
Immunizations against Respiratory Infections in Children in Primary Health Care in Poland: Coverage and Delays
Effectiveness of Immunoprophylaxis in Suppressing Carriage of Neisseria Meningitidis in the Military Environment
Detection of Influenza and Other Respiratory Viruses Carried out in the Influenza Project
Monitoring Vaccine Effectiveness (I-MOVE)
Cytokines and Toll-like Receptors in the Immune Response to Influenza Vaccination
Vaccination Status and Perception of Influenza Vaccination in the Polish Population
Immune Efficacy of First and Repeat Trivalent Influenza Vaccine in Healthy Subjects and Hemodialysis Patients
First-line Immunosuppressive Treatment in Children with Aplastic Anemia: Rabbit Antithymocyte Globulin
Index.

Contents:
Growth, nutritional status, and pulmonary function in children with chronic recurrent bronchitis
Next-generation sequencing of 5' untranslated region of hepatitis C virus in search of minor viral variant in a patient who revealed new genotype while on antiviral treatment
Swelling of erectile nasal tissue induced by human sexual pheromone
Influenza vaccination coverage rate for medical staff: influence of hospital-based vaccination campaign
Relationships between tobacco abuse and self-assessment of health
The role of inspiratory muscle training in the process of rehabilitation of patients with chronic obstructive pulmonary disease
Socioeconomic effects of chronic obstructive pulmonary disease from the public payer's perspective in Poland
Costs of treatment of chronic obstructive pulmonary disease
Coexpression of galanin and nestin in the chemoreceptor cells of the human carotid body
Prosthetic rehabilitation of patients after surgical treatment of maxillary tumors with respect to upper airway protection
Respiratory toxicity of dimethyl sulfoxide.

Summary: This book disentangles the complex meanings of responsibility in nanotechnology development by focusing on its theoretical and empirical dimensions. The notion of responsibility is extremely diversified in the public discourse of nanoscale technologies. Addressed are major disciplinary perspectives working on nanotechnology, e.g. philosophy, sociology, and political science, as well as the major multidisciplinary areas relevant to the innovation process, e.g. technology assessment and ethics. Furthermore, the interplay between such expertises, disciplines, and research programmes in providing a multidisciplinary understanding of responsibility is emphasized.

Contents:
Introduction. Nanotechnologies and the quest for responsibility; Simone Arnaldi, Arianna Ferrari, Paolo Magaudda, Francesca Marin
Part 1 Scrutinizing responsibility. Theoretical explorations into an entangled concept
Responsibility and visions in the new and emerging technologies; Arianna Ferrari, Francesca Marin
Features of intergenerational moral responsibility in the age of the emerging technologies; Silvia Zullo
The Role of responsible stewardship in nanotechnology and synthetic biology; Ilaria Anna Colussi
Part 2 Technology assessment and public engagement
Technology assessment beyond toxicology
the case of nanomaterials; Torsten Fleischer, Jutta Jahnel, Stefanie B. Seitz
Ethics Research Committees in reviewing nanotechnology clinical trials protocol; Viviana Daloiso, Antonio G. Spagnolo.-Governance of Nanotechnology: engagement and public participation; Giuseppe Pellegrini
Part 3 Representations and arrangements of responsibility
Value chain responsibility in emerging technologies; Colette Bos, Harro van Lente
On being responsible: Multiplicity in responsible development; Sarah R. Davies, Cecilie Glerup, Maja Horst
Nanotechnology and configurations of responsibilities in boundary organizations; Paolo Magaudda
Who is responsible? Nanotechnology and responsibility in the Italian daily press; Simone Arnaldi
Epilogue: Nanotechnology beyond nanotechnologies Responsible Research and Innovation: an emerging issue in research policy rooted in the debate on nanotechnology; Armin Grunwald
Index.

Summary: Disrupt and push back against capitalism and white supremacy. In this book, Tricia Hersey, aka The Nap Bishop, encourages us to connect to the liberating power of rest, daydreaming, and naps as a foundation for healing and justice. What would it be like to live in a well-rested world? Far too many of us have claimed productivity as the cornerstone of success. Brainwashed by capitalism, we subject our bodies and minds to work at an unrealistic, damaging, and machine-level pace -- feeding into the same engine that enslaved millions into brutal labor for its own relentless benefit. In Rest Is Resistance, Tricia Hersey, aka the Nap Bishop, casts an illuminating light on our troubled relationship with rest and how to imagine and dream our way to a future where rest is exalted. Our worth does not reside in how much we produce, especially not for a system that exploits and dehumanizes us. Rest, in its simplest form, becomes an act of resistance and a reclaiming of power because it asserts our most basic humanity. We are enough. The systems cannot have us. Rest Is Resistance is rooted in spiritual energy and centered in Black liberation, womanism, somatics, and Afrofuturism. With captivating storytelling and practical advice, all delivered in Hersey's lyrical voice and informed by her deep experience in theology, activism, and performance art, Rest Is Resistance is a call to action, a battle cry, a field guide, and a manifesto for all of us who are sleep deprived, searching for justice, and longing to be liberated from the oppressive grip of Grind Culture.

Contents:
RLS/WED: criteria, differential diagnosis and prevalence of occurrence / Luigi Ferini-Strambi
Mental health disorders associated with RLS / Mark A. Oldham and Hochang B. Lee
Sleep impact: insomnia, hypersomnia, sleep attacks, and Circadian disorders / Maria Turchese Caletti and Federica Provini
Cognitive functioning / Stephany Fulda
Health-related quality of life and depression symptom measures for the assessment of treatment in Restless Legs Syndrom/Willis-Ekbom disease / Jan Wesstrom
Epidemiologic evidence in cardiovascular disease / Xiang Gao and Brian Koo
Heart rate and blood pressure changes associated with Periodic Limb Movements / Raffaele Ferri and Fouzia Siddiqui
Willis-Ekbom disease, Periodic Limb Movements of sleep, and cardiovascular disease: putative mechanisms and implications for long term treatment / Lynn Marie Trotti
Peripheral muscle changes / B. Wåhlin-Larsson and J. Ulfberg
Outcome and mortality in renal failure related RLS / S. Lorenzut, S. de Biase and G.L. Gigli
Long-term efficacy of pharmacological treatment / Pietro-Luca Ratti
Augmentation: criteria, prevalence, and differential diagnosis / Diego García-Borreguero, Mauro Manconi and Luigi Ferini-Strambini --Treatment options when short-acting dopamine agonists fail or cause augmentation: switching or adding medications / Mark Buchfuhrer
Management of augmentation / Diego García-Borreguero
Managing concurrent medications / Denise Sharon
Impulsive behaviors: definition, prevalence, neurobiology, and management / Gary P.H. Ho, Charlene E. Gamaldo, Seema Gulyani and Rachel E. Salas
Impulse control behavior in movement disorders: focus on Restless Leg Syndrome / Salvatore Galati
Management of RLS during pregnancy / Mauro Manconi
Management of RLS in children (unique features) / Oliviero Bruni and Marco Angriman.

Summary: This book offers a comprehensive set of principles that lead to ideal outcomes following treatment for Head and Neck Cancers, especially in those patients who need major reconstructive procedures. It goes beyond the scope of basic Head and Neck Cancer textbooks, or of reconstructive surgery texts, in that the essential focus is on optimal outcomes beyond fundamental evaluation and management. The book addresses a range of essential aspects: the chapters on Functional and Aesthetic considerations underscore crucial basics that should be understood by all surgeons, while other chapters relevant to all members of the Head and Neck team address Imaging, Robotics, Radiation Morbidities, Prosthetics and Quality of Life. Throughout the book, particular attention is given to high-quality photographs, flow diagrams and tables wherever possible, combined with crisp writing to achieve effective communication. The book is unique in the completeness of its approach: from the time of initial presentation, to the time patients resume their normal lives. Although written primarily for surgeons, its value extends to all members of the multi-disciplinary team managing Head and Neck Cancer patients today.

Contents:
Introduction and Purpose
Fundamental Planning: Excision
Fundamental Planning: Reconstruction
Functional Considerations
Aesthetic Considerations
Choosing the â#x80;Rightâ#x80;#x99; Flap, using it the â#x80;Rightâ#x80;#x99; Way.-Oral Cavity
Region-wise.-Pharynx/Larynx: Neck
Nose
Mid-face
Post-maxillectomy Reconstruction
Eyelids
Forehead
Scalp
Skull Base
Trachea and Larynx
Special Considerations: Previously Treated Patients
Workhorse Flaps: Technical Details and Tips
Local Flaps
Regional Flaps
Free Flaps
Psychological Impacts of Major Treatment
Common Causes of Morbidity: Prevention & Management
Rehabilitation
Palliative Care.

Contents:
1. Endodontic considerations for the restoration of endodontically treated teeth --2. Effect of endodontic treatment procedures on canal shape and mechanical properties of a tooth
3. Restoring the endodontically treated tooth: treatment planning considerations
4. Fiber-reinforced dental materials in the restoration of root-canal treated teeth
5. Biomechanical principles of root canal-treated-teeth restored with fiber-reinforced resin posts
6. Fiber-reinforced resin posts (fiber posts)
7. Adhesion to root dentin: a challenging task
8. Methods for increasing the longevity of adhesion to root canal dentin
9. Selection of luting materials for bonding fiber posts
10. Provisional restorations
11. Cast dowel and core
12. Clinical sequence.

Summary: "This thoroughly updated second edition of Restoring the Brain is the definitive book on the theory and the practice of Infra-Low Frequency brain training. It provides a comprehensive look at the process of neurofeedback within the emerging field of neuromodulation and essential knowledge of functional neuroanatomy and neural dynamics to successfully restore brain function. Integrating the latest research, this thoroughly revised edition focuses on current innovations in mechanisms-based training that are scalable and can be deployed at any stage of human development. Included in this edition are new chapters on clinical data and case studies for new applications; using neurofeedback for early childhood developmental disorders; integrating neurofeedback with psychotherapy; the impact of low-frequency neurofeedback on depression; the issue of trauma from war or abuse; and physical damage to the brain. Practitioners and researchers in psychiatry, medicine, and behavioral health will gain a wealth of knowledge and tools for effectively using neurofeedback to recover and enhance the functional competence of the brain"-- Provided by publisher.

Contents:
Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
Foreword
Preface
Notes on Editor and Contributors
Acknowledgments
Introduction
Part I: Development, History, and Theory of Neurofeedback
1. Changing the Paradigm from Neurochemical to Neuroelectrical models
1.1 The Early Days of Speculation
1.2 The Soups and the Sparks
1.3 The Neurochemical Paradigm
1.4 Moving to a New Paradigm
1.5 Traditional Wave Bands
1.6 Conclusion
Notes
2. History of Neurofeedback
2.1 The Scientific Antecedents of Neurofeedback 2.2 The Foundations of Neurofeedback in Animal Studies
2.3 Evaluation of SMR Reinforcement with Human Subjects
2.4 Neurofeedback in Application to Addictions
2.5 Slow Cortical Potential Training
2.6 New Departures in Neurofeedback
2.7 Status of the Principal Approaches to Neurofeedback
2.8 Toward a New Departure in Feedback
2.9 The Development of Infra-Low Frequency Training
2.10 Toward an Understanding of Covert, Continuous ILF Neurofeedback
2.11 A Summary Perspective
Notes
3. Toward a Theory of Infra-Low Frequency Neurofeedback
3.1 Introduction 3.2 Categories of Brain Dysfunction
3.3 The Trauma Model
3.4 Mechanisms of Regulation: Historical Roots of the Slow Cortical Potential
3.5 ILF Neurofeedback in the Frequency Domain: The Frequency Rules
3.6 A Resonance Phenomenon
3.7 Implications for Inter-hemispheric Coordination
3.8 Foundational Research in Characterization of ILF Neurofeedback
3.9 Summary and Conclusion
Notes
4. Astrocytes and Infra-Low Frequencies
4.1 Introduction
4.2 Rhythmicity of the Brain and Energy Cycles
4.3 Implications for Neurofeedback
Notes Part II: Neurofeedback in Clinical Practice Settings
5. Neurofeedback in Clinical Practice
5.1 O verview of the Clinical Process and Development of Individual Treatment Plans
5.2 Combining the ILF Approach with Proven Older Neurofeedback Methods
5.3 Closing Remarks for Neurofeedback Clinicians
Notes
6. Neurofeedback in an Integrative Medical Practice
6.1 Introduction
6.2 Assessment and Screening
6.3 Case Presentations
6.4 Conclusion
Notes
7. Neurofeedback in Combination with Psychotherapy
7.1 Overview 7.2 Case Study #1: Bipolar I Disorder, Postpartum Mixed Episode
7.3 Case Study #2: Severe Generalized Anxiety Disorder with Severe Alcohol Use Disorder
7.4 Conclusion
Notes
8. Remediating Brain Instabilities in a Neurology Practice
8.1 Introduction
8.2 Case Vignettes
8.3 Exploiting Neuroplasticity
8.4 Patient Selection
8.5 Prescribing Brain Training Protocols
8.6 Viewpoints: Neurofeedback Practice in a Neurology Office
8.7 Summary Statement
Notes
Part III: Specific Applications Areas of Neurofeedback

Summary: "A collection of 28 excerpted passages from Indigenous leaders that reflect the wisdom of Indigenous worldview precepts, accompanied by analysis"-- Provided by publisher.

Contents:
Recognition of spiritual energies in nature / Mourning Dove (Okanagan and Sinixt)
Nonhierarchial society / Wenona Victor Hall (Sto:lo)
Courage and fearless trust in the universe / Berta Cá́ceres and Bertha Zúñiga Cáceres (Lenca)
Understanding/embracing death and dying / Coyote Marie Hunter-Ripper (Cherokee, Choctaw)
Emphasis on community welfare / Doñ̃a Enriqueta Contreras (Zapotecan)
High respect for the sacred feminine / Paula Gunn Allen (Laguna Pueblo)
Respect for gender role fluidity / Laura Hall (Haudenosaunee)
Nonmaterialistic barter, gift, and kinship economics / Rebecca Adamson (Cherokee)
All earth entities are sentient / Robin Wall Kimmerer (Citizen Potowatomi Nation)
The sacred nature of competition and games / Sharon and Shirley Firth (Gwich'in)
Nonanthropocentrism / Terry LeBlanc (Mi'kmaq)
Words are sacred (Truthfulness) / Ed McGaa, aka Eagle Man (Oglala Lakota)
Mutual dependence / Jack Forbes (Powhatan-Lenape, Delaware-Lenape) Complimentary duality / Barbara Alice Mann (Seneca)
Generosity as way of life / Martin Brokenleg (Lakota)
Ceremony as life sustaining / Linda Hogan (Chickasaw)
Humor as essential / Charlie Hill (Oneida Oneida-Mohawk-Cree)
Conflict resolution as return to community / Wanda D. McCaslin (Métis)
Laws of nature as highest rules for living / Winona LaDuke (Ojibwe)
Becoming fully human / Greg Cajete (Tewa, Santa Clara Pueblo)
Nature seen as benevolent / Basil Johnston (Wasauksing)
Responsibility emphasis / Xiuhtezcatl Martinez (Aztec)
Connection to the land / Enrigue Salmón (Raramuri-Tarahuamara)
Centrality of gratitude / Audrey Shenandoah (Onondaga)
Noninterference / Clare Brant (Mohawk, Wolf Clan)
Circular time and knowledge / Tyson Yunkaporta (Apalech Clan in far north Queensland)
Self-initiated relational healing / Gloria Lee (Cree-Pelican Lake)
An emphasis on heart wisdom / Ilarion "Larry" Merculieff (Unangan).

Contents:
Executive summary
Research methods
Sample
Data analyses
Results
2016 current practices in residency selection survey.

Summary: Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.

Contents:
Part I: State of the Art in Resuscitation
Part II. Advances on Cardiopulmonary Resuscitation (CPR) and Defibrillation
Part III. Optimization of Cardiopulmonary and Cerebral Resuscitation on Sudden Cardiac Death
Part IV. Pharmacological Approach during CPR
Part V. Post-Resuscitation Care
Part VI. Combining Physiology, Clinical Outcome, and Ethics.

Summary: Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex. Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required. Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martín demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies' proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and sceptical assessment. -- Provided by publisher.

Contents:
Introduction : challenging mainstream defenses of reprogenetic technologies
Reprogenetic technologies : an overview
Procreative liberty : the moral permissibility of reprogenetics
Conscripted in the pursuit of perfection : the moral obligation to use reprogenetic technologies
The illusion of control : reprogenetic technologies and the natural lottery
Not of woman born : reprogenetics and the erasing of women
Different things delight different people : on the value-neutrality of reprogenetic technologies
Enhancing the assessment of reprogenetic technologies : the case of mitochondrial replacement.

Summary: This volume presents a novel logic-based, simplified understanding and approach to the external nose and face for aesthetics, airway, and sleep treatments that have mostly been under-recognized in the past. Key features of the text include an engineers approach to simple rhinoplasty, (Release, Resize, Reposition, Reinforce) instead of the typical step-wise procedure algorithm. It also includes a logical explanation of how facial skeletal anatomy is the true cause of sleep apnea and aesthetic deformity with the physics and evidence of how this works, and a review of conventional rhinoplasty/facial structural treatments, with an analysis of why these are flawed and need improvement. Finally, rhinoplasty surgical strategy is discussed using a Rhinoplasty Compass(TM) diagram. Rethinking Rhinoplasty and Facial Surgery appeals to the surgeon who has grown frustrated with the aesthetic and breathing results of the conventional treatment paradigm. It also appeals to the otolaryngologist, plastic or oral surgeon who avoids working on the external nose and nasal valve because of the perceived complexity of graft-style rhinoplasty or oversimplicity and limitations of basic septoplasty and turbinate reduction. This book provides a hybrid approach to the nose and face that provides more reliable and straightforward outcomes via an understanding of framework.

Contents:
Part I Toward an understanding of structure/function interaction
Chapter 1 The problem we face: The "compartmentalized" conventional view of facial/nasal anatomy
Chapter 2 The invisible forces in our nasal airway: Air flow and cavity negative pressure
Chapter 3 Nasal function and Sleep Disorders
Chapter 4 The human facial skeleton: influence on the airway and aesthetics?
Part II Rhinoplasty Strategy and Tactics
Chapter 5 A structural model to systematically understand nasal framework: The Rhinoplasty Compass
Chapter 6 Modeling to evaluate conventional procedures
Chapter 7 Rhinoplasty Strategy and Tactics using the Rhinoplasty Compass
Chapter 8 Complementary procedures to the Framework Strategy (The Canopy Layer)
Chapter 9 Strategies for addressing mouth-breathing treatment with an "Adequate" nose
Chapter 10 Breaking the barriers between specialties: Toward a universal understanding of anatomy and function.

Summary: "There are significant barriers to its study beyond the constricted pupil. Ophthalmology trainees first acquire the observational skills and facility with diagnostic instrumentation such as the slit lamp biomicroscope"--Provided by publisher.

Summary: This book covers the entire spectrum of retinology from basic genetics to clinical assessment, from common diseases to rare syndromes, and from simple medical treatment to complex vitreoretinal surgical procedures. The reader will learn about the retina in its entirety, which is fundamental to ophthalmic expertise. To aid in self-assessment, the book includes multiple-choice questions in exam format, which include detailed answers and are supplemented with diagrams and photos (from the authors personal library of patient photos). The book is intended for those sitting for the popular post-graduate degrees in ophthalmology in Europe (EBO), the traditional Royal College of Ophthalmology exams (RCO) and their Asian counterparts, including the ICO. It will also be of interest to qualified ophthalmic surgeons/ophthalmologists and can be used to self-assess readers current state of knowledge.

Contents:
Intro
Preface
Contents
Abbreviations
1 Basic Anatomy, Embryology and Physiology of the Retina
1 Answers
2 Answers in Detail
References
2 Retinal Testing and Imaging
1 Answers
2 Answers in Detail
References
3 Retinal Vascular Disease
1 Answers
2 Answers in Detail
References
4 Retinal Degeneration and Dystrophies
1 Answers
2 Answers in Detail
References
5 Disorders of the Macula
1 Answers
2 Answers in Detail
References
6 Vitreous and Vitreoretinal Interface Pathology
1 Answers
2 Answers in Detail
References 7 Drug-Induced Retinopathies
1 Answers
2 Answers in Detail
References
8 Vitreoretinal Surgery
1 Answers
2 Answers in Detail
References
9 Choroidal and Retinal Tumours
1 Answers
2 Answers in Detail
References
10 Retinal Imaging
References
Index

Summary: "A day-to-day guide on the diagnosis and management of routine to complex retinal disorders The diagnosis and treatment of retinal eye disorders often presents significant clinical challenges. The Retina Illustrated by renowned retina specialist Justis Ehlers and an impressive group of worldwide contributors provides a rapid-fire, yet thorough approach to the visual world of retinal disease. Organized by ten sections and 102 succinct yet comprehensive chapters, this richly illustrated reference covers the full spectrum of retinal disorders, ranging from common degenerative diseases to emerging viral conditions. The book opens with discussion of state-of-the-art diagnostic tools, followed by nine disorder-specific sections describing diagnosis and treatment of degenerative, infectious, inflammatory, vascular, traumatic, viral, cancerous, and pharmacologic-related retina conditions. The text covers the full age continuum, from conditions primarily impacting older adults, such as age-related macular degeneration and choroidal atrophy, to pediatric disorders, such as retinopathy of prematurity. Key Features Discussion of cutting-edge imaging diagnostics, including ultra-widefield angiography, intraoperative optical coherence tomography, and OCT angiography More than 400 high-quality illustrations augment the text, enhancing understanding of retinal disease, from symptoms and signs to differential diagnosis and management A section dedicated to infectious and inflammatory disorders encompasses retinopathies associated with HIV, West Nile, Ebola, and Zika This is a must-have reference for all providers who encounter patients with retinal disease, including general ophthalmologists, retina specialists, emergency medicine physicians, and optometrists. Ophthalmology residents and fellows in training will also find this book an invaluable education tool"-- Provided by publisher.

Summary: This is a concise how-to of successfully treating previously deemed "untreatable" retinal and optic nerve conditions with stem cell therapies. Based on the results of 11 years of experience treating approximately 600 patients, this text will serve as a template for others to develop similar stem cell based treatments in their specialty. Author, Jeffrey N. Weiss, MD is specifically poised to offer dependable insight on stem cell surgery for both the retina and the optic nerve, having performed the first retinal stem cell surgery in 2010, with Institutional Review Board (IRB) approved studies that are registered with the National Institute of Health (NIH), and listed on ClinicalTrials.gov. Featuring all original work from Dr. Jeffrey Weiss's specialization in stem cell ophthalmology, this book is primarily written for ophthalmologists, but structured so that specialists across disciplines can take the model presented and create their own studies and clinical trials using stem cell therapies.

Contents:
1. Stem Cells, PRP, Definitions, FDA
2. History of Retinal Stem Cell Surgery
3. Funding
4. ClinicalTrials.gov listings
5. Study Protocols
6. Study Design/Method/Procedures
7. Informed Consent
8. Procedure
Additional Patient Explanation
9. Photos
10. Some Thoughts for the Future
11. Publications
12. Frequently Asked Questions (FAQ).

Contents:
Normal
Hereditary chorioretinal dystrophies
Pediatrics
Inflammation
Infection
Retinal vascular disease
Degeneration
Oncology
Vitreomacular traction, epiretinal membranes, and macular holes
Central serous chorioretinopathy and other exudative detachments
Peripheral retinal degenerations and rhegmatogenous retinal detachment
Traumatic chorioretinopathy
Complications of ocular surgery
Chorioretinal toxicities
Congenital and developmental anomalies of the optic nerve.

Summary: "This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy."--Publisher's website.

Contents:
Part I. Basic processes: development, physiology and function
Part II. Basic processes: RPE
Part III. Basic processes: methodology
Part IV. Genetics in retinal disease
Part V. AMD: novel developments
Müller cells, microglia, and macrophages
Part VII. Degenerative processes: immune-related mechanisms, genes and factors
Part VII. Degenerative processes: RPE and fatty acids
Part IX. Degenerative processes: immune-related mechanisms, genes and factors
Part X. Therapy: gene therapy
Part XI. Therapy: protection
Index.

Summary: The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

Contents:
Part I. Age-related macular degeneration (AMD)
Part II. Gene therapies
Part III. In-vivo diagnostics for structure and function
Part IV. Inflammation and angiogenesis
Part V. Inherited retinal degenerations
Part VI. Mechanisms of degeneration
Part VII. Neuroprotection
Part VIII. Retinal cell biology
Part IX. Stem Cells.

Summary: This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume. .

Summary: This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.

Summary: This clinically oriented book provides a complete overview of Proliferative vitreoretinopathy (PVR) Retinal Detachment, a difficult surgical challenge faced by ophthalmologists. Small gauge vitrectomy offers new possibilities to tackle this difficult pathology however this surgical approach may differ from one retinal surgeon to the next. To reflect the various approaches to treating PVR, the book is divided up in three parts. In the first part the authors describe the complete variety of surgical techniques applied to PVR detachment. In the second section, well-known international surgeons from Europe to Asia describe their personal surgical approach for PVR detachment and demonstrate their surgery in videos. In the third part, a large variety of retinal surgeons show case reports of PVR retinal detachment to give a complete overview of dealing with this complex retinal disorder.

Summary: This clinically oriented book provides a complete overview of retinal detachment and Proliferative vitreoretinopathy (PVR), a difficult surgical challenge faced by ophthalmologists. Small gauge vitrectomy offers new possibilities to tackle this difficult pathology however this surgical approach may differ from one retinal surgeon to the next. To reflect the various approaches to treating PVR, the book is divided up in three parts. In the first part the authors describe the complete variety of surgical techniques applied to retinal detachment. In the second section, the surgical approach for PVR detachment is demonstrated step-by-step. In the third part, a large variety of retinal surgeons from Europe discuss video case reports of PVR retinal detachment to give a complete overview of dealing with this complex retinal disorder. The book is practical, down to earth, the surgeries are explained in detail, illustrated with drawings, photographs and refers to a huge number of videos available via Dr. Spandaus YouTube channel.

Contents:
Proliferative Vitreoretinopathy (PVR): An Introduction
Before Surgery
Surgery
After Surgery. Proliferative Vitreoretinopathy (PVR) An International Approach
Surgical Trends and Case Reports.

Summary: Classically, photo atlases of retinal dystrophies have been divided into sections that describe and depict a particular retinal finding or disease, after which a differential diagnosis of potential diseases or mutated genes is provided. However, given the rapid improvement in molecular diagnostics, and the exponential increase in our understanding of the phenotypes caused by each mutated gene, the paradigm has changed. Physicians are now more interested in the variable expressivity associated with mutations in each individual gene. Therefore, Retinal Dystrophy Gene Atlas catalogs the different phenotypes that have been reported with each mutated gene. Each section describes a gene and its known clinical phenotypes and features of disease, along with retinal photos of affected patients. Written by prominent retinal dystrophy specialists from the largest dystrophy centers worldwide, Retinal Dystrophy Gene Atlas contains more than 80 chapters, each of which describes the clinical and photographic manifestations of a specific gene. The chapters include stunning clinical color photographs of the retina, autofluorescence imaging, electrophysiologic findings, and cross-sectional imaging. Retinal Dystrophy Gene Atlas serves as a resource to aid genetic diagnosis in patients with retinal dystrophies.

Contents:
Part I. Autosomal Dominant Inheritance
1. BEST1
2. CRX
3. CTRP5
4. EFEMP1
5. ELOVL4
6. FSCN2
7. GNAT1
8. GUCA1A
9. GUCA1B
10. GUCY2D
11. IMPDH1 (RP10)
12. JAG1
13. KLHL7
14. PROM1
15. PRPF3 (RP18)
16. PRPF31
17. PRPF8 (RP18)
18. PRPH2 (RDS)
19. RBP3
20. RGR
21. RHO
22. RLPB1
23. RP1
24. RIMS1
25. SEMA4A
26. SNRNP200
27. TIMP3
28. TOPORS
29. TTC8
30. VCAN
31. WFS1
Part II. Autosomal Recessive Inheritance
32. ABCA4
33. AIPL1
34. ALMS1
35. ARL6
36. BBS1
37. BBS10
38. BBS12
39. BBS2
40. BBS4
41. BBS5
42. BBS7
43. BBS9
44. C2ORF71
45. C8ORF37
46. CDH23
47. CEP290
48. CERKL
49. CLN3
50. CLRN1
51. CNGA1
52. CNGA3
53. CNGB1
54. CNGB3
55. CRB1
56. CYP4V2
57. DFNB31
58. DHDDS
59. EYS
60. FAM161A
61. GNAT2
62. GPR98
63. IDH3B
64. IMPG1
65. IQCB1
66. KCNV2
67. KCNJ13
68. LCA5
69. LRAT
70. MAK
71. MERTK
72. MYO7A
73. NMNAT1
74. NR2E3
75. NRL
76. OAT
77. PDE6A
78. PDE6B
79. PDE6C
80. PDE6G
81. PDE6H
82. PEX7
83. PHYH
84. PRCD
85. RD3
86. RDH5
87. RDH12
88. RPE65
89. RPGRIP1
90. SAG
91. SPATA7
92. TULP1
93. USH1C
94. USH1G
95. USH2A
96. ZNF513
Part III. X-Linked Inheritance
97. CACNA1F
98. CHM
99. NYX
100. OPN1LW
101. RP2
102. RPGR
103. RS1.

Contents:
Intro
Preface
Contents
About the Editors
Part I: Physiological RPE Function
1: RPE Histopathology and Morphometry
Introduction
Normal Histology
Cell Morphometry
Pleomorphism, Polymegathism
Spatial Distribution, Topography
Pathology
Age-Related Changes
Degenerations
Biometry-Related Changes
Age-Related Macular Degeneration
Retinal Dystrophies
Proliferative Retinopathies
Mitochondrial Diseases
RPE Tumors
References
2: RPE Polarity and Barrier Function
Introduction The Blood-Retinal Barrier (BRB) Is a Division of the Blood-Brain Barrier (BBB)
Properties of a Blood-Tissue Barrier
Epithelial Contributions to the Blood Retinal Barrier (BRB)
Differentiation vs Maturation In Vivo and in Culture
What Is an RPE Cell?
Maturation of RPE Barrier Function in Chick Embryos and Small Mammals
Maturation of RPE Barrier Function in Humans
The Structure of Tight Junctions and Pathways for Solutes to Traverse Them
Protein Composition
Claudins Are Major Determinants for the Selectivity and Permeability of Tight Junctions Claudins Regulate Additional Pathways of Barrier Function Through Effects on Gene Expression
Analysis of Paracellular Barrier Function
Permeation of Polymeric Solutes
Electrophysiological Assays
Analysis of RPE Tight Junctions by Multiple Assays
The Interplay of Tight Junctions and Membrane Transporters
Retinal Pathology and RPE
Conclusions
References
3: RPE Phagocytosis
Introduction
Experimental Approaches to Quantify the Phagocytic Function of the RPE
Molecular Mechanisms of RPE Phagocytosis
Recognition and Binding of POS by RPE Cells Cell Surface Receptors and RPE Signaling Pathways Mediating POS Internalization
Processing and Degradation of Phagocytosed POS by RPE Cells
Defects in POS Clearance Phagocytosis by RPE Cells and Human Retinal Disease
Outlook
References
4: Ion Channels of the Retinal Pigment Epithelium
Introduction
Ionic Mechanisms of RPE Function
Epithelial Transport
Ion Channels That Contribute to Transepithelial Ion Transport by the RPE
K+ Buffering in the Subretinal Space
Ion Channels Contributing to the Control of Subretinal K+ Homeostasis Ca2+-Signaling to Regulate RPE Functions
Secretion
Epithelial Transport
Phagocytosis
Summary
References
5: RPE and the Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor
RPE Derived VEGF Function in the Healthy Retina
Development
Adult Retina
RPE Derived VEGF in the Diseased Retina
Regulation of VEGF in the RPE
Constitutive VEGF
Hypoxia
Oxidative Stress and Hyperglycemia
Inflammation
Hyperthermia
Conclusion
References
6: The RPE Cell and the Immune System
Introduction
RPE Cell: Role in Ocular Innate Immunity

Summary: Intended as a useful and practical guide primarily oriented toward ophthalmic practitioners involved in retinal prosthesis implantation and post-operative visual rehabilitation, this book focuses on the Argus II Retinal Prosthesis and its revolutionary incorporation into the practice. The reader will get an update on patient selection, expected visual outcomes, surgical implantation techniques, and post-operative visual rehabilitation. Retinal Prosthesis - A Clinical Guide to Successful Implementation is written in a clear and concise manner and includes diagrams and high quality photographs to demonstrate best practices in surgical techniques and desired outcomes. Covering topics such as history of retinal prostheses, bioengineering considerations, clinical therapies, and other therapies and future directions, this book is written for practicing ophthalmologists, residents, and medical students interested in retinal implants.

Summary: This atlas extensively covers numerous aspects of retinal vascular disease, e.g. topics in retinal and vascular imaging ranging from common diseases such as diabetic and hypertensive retinopathy to rarer entities including sickle cell retinopathy and Coats disease. It primarily focuses on the imaging of these disorders, while also discussing various therapies and management decisions. Retinal Vascular Disease is one of nine volumes in the series Retina Atlas. The series offers a global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, ocular inflammatory disease, retinal degeneration, surgical retina, macular disorders, ocular oncology, pediatric retina and trauma. In nine volumes and over 100 chapters, Retina Atlas offers comprehensive and validated information on retinal disorders.

Contents:
Imaging of retinal vascular disease
Retinal artery occlusion
Branch retinal vein occlusion
Central retinal vein occlusion
Hypertensive retinopathy
Sickle cell retinopathy
Diabetic retinopathy
Ocular ischemic syndrome
Takayasu arteritis
Retinal arterial macroaneurysm
Coats disease
Susac syndrome
Eales disease.

Contents:
Front Matter
Chapter 1: How the Baby Product Industry Affects Your Child's Development
Chapter 2: Set a Solid Foundation-Grow, Baby, Grow!
Chapter 3: How Senses and Experiences Shape Your Baby's World
Chapter 4: Keep Your Sleeping Baby Safe and Practice Tummy Time
Chapter 5: Prevent Positional Skull Deformities
Chapter 6: Building a Solid Sensory-Motor Foundation: Birth to 3 Months
Chapter 7: Enhancing Development With Retro Activities: 4 to 6 Months Chapter 8: Enhancing Development With Retro Activities: 7 to 9 Months
Chapter 9: Enhancing Development With Retro Activities: 10 to 12 Months
Chapter 10: Enhancing Development With Retro Activities: 13 to 24 Months
Epilogue
References
Index

Summary: "Parents of toddlers will learn about brain development and the importance of daily active play with Retro Toddler"--Publisher's description.

Contents:
The ABCs of brain development
Early movement matters
Parenting your toddler : why "back to the basics" is best
Why old-fashioned play is critical during the toddler years
How screen time and digital media use are affecting today's young children
Enhancing development with retro activities : 12 to 18 months
Enhancing development with retro activities : 19 to 24 months
Enhancing development with retro activities : 25 to 30 months
Enhancing development with retro activities : 31 to 36 months.

Summary: This book offers a comprehensive overview of performing return-on-investment (ROI) analyses for healthcare quality improvement (QI). In the United States, healthcare policy regarding physician and facility payment/reimbursement is steadily trending towards the use of "value-based" systems and away from the traditional "fee-for-service" (FFS) payment mechanisms. Healthcare professionals and organizations who have previously focused on quality metrics are now finding themselves burdened with having to define and assess value metrics, without much guidance or assistance. This volume aims to be a guide and a reference for healthcare professionals tasked with estimating and establishing ROI for QI. Chapters describe the general framework for how to perform QI; establish standard definitions of important terms, concepts, and calculations; and provide specific instructions for how to complete each step of an ROI analysis. These include: selecting a QI initiative and identifying the associated metrics, establishing measurable, monetizable, and attributable costs and benefits, determining the appropriate scope and perspective, calculating ROI and related metrics (payback period, benefit-to-cost ratio, etc.), comparing with established benchmarks or previously published results, and interpreting the results for the intended audience. In addition, chapters offer examples of real studies (or hypothetical studies of real situations), as well as templates for several of the necessary activities that readers can leverage for their own use. Return on Investment for Healthcare Quality Improvement is a must-have resource for healthcare providers, administrators, and other professionals who work in healthcare organizations, hospitals and other healthcare settings, health systems, and residency programs seeking to obtain outside funding, as well as policy makers and administrators of federal programs.

Contents:
Chapter 1. Introduction
Chapter 2. Planning an ROI Analysis
Chapter 3. Initial Steps
Chapter 4. Costs and Benefits
Chapter 5. Performing Base Case and Sensitivity Analyses
Chapter 6. Interpretation and Presentation
Chapter 7. Hypothetical Case Studies
Chapter 8. Tips and Templates
Chapter 9. Expanded Topics in ROI.

Summary: Return to training (RTT) and return to play (RTP) decisions making process in football are currently based on expert's opinion. However, there are no consensus guidelines on evidence-based decision-making. This book provides a framework for evidence-based decision-making both in RTT and RTP following lower-limb muscle injuries sustained in football. Based on the Italian Consensus Conference (2019) on return-to-play after lower limb muscle injury in football, it provides a list of RTT and RTP criteria after such injuries compiled by orthopedic surgeons, sports physicians, radiologists, rehabilitation physicians, sport physiologists, general surgeons, family physicians, physiotherapists, physical trainers and psychologists working in elite football in Italy. The book identifies the main criteria for RTT and RTP following injuries involving the most important muscle groups, i.e. quadriceps, hamstring, hip adductor, hip external rotator, iliopsoas and soleus-gastrocnemius. As such it is a valuable reference resource for practitioners making RTT and RTP decisions making process.

Contents:
1 The return to training general(RTT) principles
2 The return to play (RTP) general principles
3 RTT and RTP after quadriceps injury
4 RTT and RTP after hamstring injury
5 RTT and RTP after adductors injuries
6 RTT and RTP after external hip rotators injury
7 RTT and RTP after soleus-gastrocnemius muscle injuries.

Summary: In this book, leading experts employ an evidence-based approach to provide clear practical guidance on the important question of when and how to facilitate return to play after some of the most common injuries encountered in football. Detailed attention is paid to biomechanics, the female athlete, risk factors, injury prevention, current strategies and criteria for safe return to play, and future developments. Specific topics discussed in depth include concussion, anterior cruciate ligament and other knee injuries, back pathology, rotator cuff tears, shoulder instability, hip arthroscopy, and foot and ankle injuries. The chapter authors include renowned clinicians and scientists from across the world who work in the field of orthopaedics and sports medicine. Furthermore, experiences from team physicians involved in the Olympics, National Football League (NFL), Union of European Football Associations (UEFA), and Fédération Internationale de Football Association (FIFA) are shared with the reader. All who are involved in the care of injured footballers will find this book, published in cooperation with ESSKA, to be an invaluable, comprehensive, and up-to-date reference that casts light on a range of controversial issues.

Contents:
Introduction
ACL: Criteria-based return to play
ACL: Time-based return to play
Joint specific return to play recommendations
Return to play after complex knee injries
Concussion
Medical issues and doping
Ethical issues in return to play: the role of clinical judgment
Injury and reinjury prevention.

Summary: The wealth of information provided in this unique text will enable orthopedic surgeons, medical practitioners, physical therapists, and trainers to ensure that athletes who suffer anterior cruciate ligament (ACL) injuries, or who require major knee operations for other reasons, have the best possible chance of safely resuming sporting activity at their desired level without subsequent problems. Divided into seven thematic sections, the coverage is wide-ranging and encompasses common barriers to return to sport, return to sport decision-based models, and the complete spectrum of optimal treatment for ACL injuries, including preoperative and postoperative rehabilitation. Advanced training concepts are explained in detail, with description of sports-specific programs for soccer, basketball, and tennis. Readers will find detailed guidance on objective testing for muscle strength, neuromuscular function, neurocognitive function, and cardiovascular fitness, as well as validated assessments to identify and manage psychological issues. In addition, return to sport considerations after meniscus surgery, patellofemoral realignment, articular cartilage procedures, and knee arthroplasty are discussed. Generously illustrated and heavily referenced, Return to Sport after ACL Reconstruction and Other Knee Operations is a comprehensive resource for all medical professionals and support staff working with athletes and active patients looking to get back in the game with confidence.

Contents:
Part I - Problems and Barriers for Successful Return to Sport
1.Advantages and Potential Consequences of Return to Sport After ACL Reconstruction: Quality of Life, Reinjury Rates, Knee Osteoarthritis
2. Common Symptom, Psychological, and Psychosocial Barriers to Return to Sport
3.The Arthritis Barrier: Long-Term Effects of ACL Trauma on Knee Joint Health
Part II - Return to Sport: Whose Decision Is It?
4.Return to Sport Decision-Based Models
5.Role of the Team Physician, Orthopaedic Surgeon, and Rehabilitation Specialists
6.Return to Sport After Primary ACL Reconstruction in Amateur, Children, and Elite Athletes: Feasibility and Reinjury Concerns
Part III - Spectrum of Optimal Treatment of ACL Injuries
7.What is the Scientific Basis for Knee Ligament Healing and Maturation to Restore Biomechanical Properties and a Return to Sports?
8.Preoperative Rehabilitation: Basic Principles
9.Extended Preoperative Rehabilitation: Does It Influence Return to Sport After Surgery?
10
Intraoperative Considerations Crucial for a Successful Outcome
11. Early Postoperative Rehabilitation to Avoid Complications and Prepare for Return to Sport Training
12.Early Postoperative Role of Blood Flow Restriction Therapy to Avoid Muscle Atrophy
Section IV - Return to Sport Advanced Training Concepts
13.Current Concepts of Plyometric Exercise
14.Sportsmetrics Neuromuscular Training: Basic and Advanced
15.Important Steps for Return to Sport
16."Re-establishing Neurocognitive Function: Attentional Focus and Visual-Motor Training Neurocognitive Prinicples for ACL Rehabilitation and Re-Injury Risk Reduction (?? Title)"
17. Return to Sport for Soccer and Basketball.-18.Return to Sport for Tennis
Section V - Objective Testing
19.The Physician?s Comprehensive Examination for Return to Sport
20.Neuromuscular Function, Agility, and Aerobic Testing
21.Muscle Strength and Dynamic Balance Stability Tests
22.Neurocognitive Testing
Section VI - Psychological Readiness
23.Validated Questionnaires to Measure Return to Sport and Psychological Factors
24.Return to Sport Psychological and Psychosocial Issues in the Athlete: Identification and Management of Psychosocial Issues in the Athlete for Return to Sport
Section VII - Other Knee Operations
25.Return to Sport After ACL Revision Reconstruction: Is It Advisable?
26.Return to Sport Considerations in the Pre-Adolescent Athlete
27.Return to Sport After Meniscus Operations: Meniscectomy, Repair, and Transplantation
28.Return to Sport After Patellofemoral Realignment
29.Return to Sport After Articular Cartilage Restorative Procedures
30.Return to Sport After Unicondylar, Patellofemoral, and Total Knee Arthroplasty.

Summary: Honest, compassionate advice for post-partum new moms. Having a baby is supposed to be the happiest time of a woman's life, but for some it isn't. And for many, it is the most challenging. As they learn to care for their newborns, many new mothers often face physical challenges with breastfeeding, sleep, and nutrition, and struggle with feelings of isolation, sadness, and guilt. Dr. Sriraman shares practical professional advice along with her own personal experiences and those of other mothers to help 4th trimester moms know they are not alone. From pelvic floor issues to postpartum depression, no topic is taboo. Return to You will help new moms restore themselves physically and encourage them to ask for help and give themselves the time they need to rest, recover, and heal emotionally.

Contents:
Acknowledgments
Introduction
Chapter 1: History of Postpartum Care
Chapter 2: Current State of Postpartum Care
Chapter 3: You're Pregnant...Now What?
Chapter 4: Your Postpartum Plan
Chapter 5: Role of the Father/Partner
Chapter 6: Visitors/Boundaries
Chapter 7: Infant Nutrition
Chapter 8: Postpartum Nutrition and Exercise
Chapter 9: Postpartum Depression and Anxiety
Chapter 10: Return to You
Chapter 11: Ease the Stress of Returning to Work
Chapter 12: Reconnecting With Your Partner
Chapter 13: Role of Social Media
Chapter 14: Mommy Guilt: It's Real Folks
Chapter 15: Maximizing Sleep as a New Mommy: Really, It's Not a Myth!.

Contents:
Intro
Reverse Phase Protein Array (RPPA) Global Workshop
Contents
1: RPPA: Origins, Transition to a Validated Clinical Research Tool, and Next Generations of the Technology
1.1 Opportunities and Challenges in Precision Medicine
1.2 Historical Origin of Reverse Phase Protein Microarray Technology
1.2.1 Protein Microarray Terminology
1.3 Application of RPPA Technology to Profile Individual Patient's Tumor Specimens 1.3.1 Near-Term Future Directions for RPPA (ISPY2): Discovery of Activated Kinase Signal Pathway Proteins Predicting Patient Response to New Molecular Therapy Agents
1.3.2 Side-Out Metastatic Breast Cancer Trial of Personalized Therapy
1.4 The Next Generation of RPPA Technology
1.4.1 Electronic RPPA
1.4.2 Solution Phase RPPA
1.5 Conclusions and Vision for the Future
References
2: Lysate Preparation for Reverse Phase Protein Arrays
2.1 Introduction
2.2 General Considerations
2.3 Protein Isolation from FFPE Tissues 2.4 Deparaffinization and Protein Isolation from Slide-Mounted FFPE Sections
2.4.1 Reagents
2.4.2 Equipment
2.4.3 Method
2.4.3.1 Sample Preparation
2.4.3.2 Deparaffinization
2.4.3.3 Protein Isolation
2.5 Deparaffinization and Protein Isolation from FFPE Sections Cut Directly in a Tube
2.5.1 Reagents
2.5.2 Equipment
2.5.3 Method
2.5.3.1 Sample Preparation
2.5.3.2 Deparaffinization
2.5.3.3 Protein Extraction
2.6 Lysate Preparation
2.7 Troubleshooting
References 3: High Precision RPPA: Concept, Features, and Application Performance of the Integrated Zeptosens Platform
3.1 Introduction
3.2 Platform Considerations
3.2.1 Required Sensitivity
3.2.2 RPPA Alternative Approaches and Differentiation
3.2.3 Detrimental Optical Effects
3.2.4 Sample Integrity and Deterioration
3.2.5 Microarray Layout and Printing
3.2.6 Antibodies and Assays
3.2.7 Data Analysis and Quantitation
3.2.8 Information Standardization
3.2.9 Quality Demands of Drug Development and Clinical Research
3.3 Realization - Implementation 3.3.1 Sample Preparation
3.3.2 Assay and Printing Buffers
3.3.3 Microarray Substrates
3.3.4 RPPA Printing
3.3.5 Microarray Layout
3.3.6 Assay Handling Hardware and Processing
3.3.7 Assay Architecture and Antibodies
3.3.8 Fluorescence Labels
3.3.9 Imaging via the ZeptoREADER
3.3.10 Image and Data Analysis
3.3.11 Quality Issues
3.4 Application Performance Obtainable from Zeptosens RPPA
3.5 Future Needs and Trends
References
4: Solid Pin Protein Array Printing Platforms
4.1 Introduction to Reverse Phase Protein Arrays 4.1.1 Workflow for Fabricating RPPA

Contents:
Part I: History of Reverse Shoulder Arthroplasty
Origins of Reverse Shoulder Arthroplasty and Common Misconceptions
Part II: Biomechanics and Basic Science of Selected Leading Research Centers
Shoulder Biomechanics: Charité University of Medicine, Berlin, Germany
Biomechanics of the Reverse Shoulder Arthroplasty
Reverse Shoulder Biomechanics: The Research Performed at the Foundation for Orthopaedic Research and Education (FORE)
Design Optimization and Prosthesis Classification: Bordeaux-Merignac Sport Clinic, Bordeaux-Merignac, France
Motion and Muscular Function after Reverse Shoulder Arthroplasty
Biomechanics of the Normal and Reverse Shoulder
Biomechanics of the Reverse Total Shoulder Replacement: The Hospital for Special Surgery Perspective
Analysis of Reverse Total Shoulder Arthroplasty Biomechanics Using a Dynamic Shoulder Simulator
Biomechanics of Reverse Shoulder Arthroplasty: Contribution of Computer Modelling
Kinematic Analyses of Patients with Reverse Shoulder Arthroplasty
Implant Retrieval: Drexel University, Philadelphia, Pennsylvania, USA
Part III: Clinical Uses
Reverse Shoulder Arthroplasty for Massive Rotator Cuff Tears Without Glenohumeral Arthritis
Massive Rotator Cuff Arthropathy with Glenohumeral Arthritis
Intact Rotator Cuff
Reverse Shoulder Arthroplasty in the Setting of Proximal Humeral Fracture
Reverse Shoulder Arthroplasty in the Setting of Scapula Fractures
RSA with Glenoid Bone Loss
Reverse Shoulder Arthroplasty in Patients with Preoperative Deltoid Impairment
Reverse Total Shoulder Arthroplasty in the Setting of Infection
Reverse Shoulder Arthroplasty in the Setting of Proximal Humeral Bone Loss
Conversion of Failed Hemiarthroplasty to Reverse Total Shoulder Arthroplasty: Indications, Techniques, and Outcomes
Reverse Prosthesis and the Failed Total Shoulder Arthroplasty
Revision Reverse Total Shoulder Arthroplasty
Proximal Humerus Tumors
Massive Irreparable Rotator Cuff Tears: How to Rebalance the Cuff-Deficient Shoulder?
Influence of Arm Lengthening in Reverse Shoulder Arthroplasty
How to Handle the Humeral Side
Rehabilitation and Activity Expectations following RSA
Complications Associated with RSA
Part IV: Current Industry Devices and Surgical Techniques
Arthrex Univers ReversTM Shoulder Prosthesis
Aston Medical Duocentric® Reversed Prosthesis: Proposition of New Glenoid Component Design to Prevent Scapular Neck Notching
The Biomet Comprehensive© Reverse Total Shoulder System: Design Considerations and Surgical Techniques
Depuy Synthes: Joint Reconstruction: DELTA XTEND Reverse Shoulder Prosthesis
DJO Surgical ReverseTM Shoulder Prosthesis (RSPTM)
Design Features and Surgical Technique of The Scultra II Reverse Prosthesis
Evolutis UNIC Reverse Shoulder Prosthesis
Exactech Equinoxe RTSA Platform Shoulder System Design Rationale
FH Orthopedics Arrow Universal Shoulder Prosthesis
Verso® Stemless Bone Preserving Reverse Geometry Total Shoulder Replacement: (Innovative Design Orthopaedics Ltd.)
The Integra® TitanTM Reverse Shoulder System
The SMR ® Shoulder System of Lima Corporate
Mathys Affinis® Inverse
The Bayley/Walker Prosthesis: Stanmore Implants Worldwide
Tornier Aequalis AscendTM Flex Convertible Shoulder System
Zimmer Reverse Total Shoulder Arthroplasty
Part V: Economic Value
Value and Reverse Total Shoulder Arthroplasty: The Foundation for Orthopaedic Research and Education Perspective
Value and Reverse Total Shoulder Arthroplasty: The Boston Shoulder Institute Perspective.

Contents:
Basic science
Dermatopharmacology
General dermatology
Pediatric dermatology
Infectious diseases
Neoplastic dermatology --Dermatologic surgery
Cosmetic dermatology
Cutaneous manifestations of internal disease and metastases
Epidemiology, statistics, study design, and public health principles.

Contents:
The hemodialysis team
History of dialysis
Basic chemistry of body fluids and electrolytes
Kidney physiology and the pathology of kidney failure
Clinical manifestations of chronic kidney disease
Dialyzers, dialysate, and delivery systems
Principles of hemodialysis
Water treatment
Dialyzer preparation and reprocessing
Infection control
Anticoagulation and heparin administration
Access to the bloodstream
Patient and machine monitoring and assessment
Nutrition management
Laboratory data: analysis and interpretation
Diabetes and chronic kidney disease
Medication problems and dialysis
Acute kidney injury and dialysis
Peritoneal dialysis and home dialysis therapies
Transplantation
Pediatric dialysis
Chronic kidney disease in the elderly
Case management of the chronic kidney disease patient
Psychosocial aspects of dialysis therapy
Patient education guidelines
Management of quality in dialysis care
On being a preceptor
Basic math calculations
Test-taking guidelines
Appendices. Nephrology organizations and resources
High-potassium foods to limit or avoid
High-sodium foods to limit or avoid
High-phosphorus foods to limit or avoid
Dialysis lab tests at a glance

Summary: "Offering a complete review for radiology residents and radiologic technologists preparing for certification, Review of Radiologic Physics, 5th Edition, by Dr. William F. Sensakovic, is a high-yield, efficient resource for today's clinically focused exams. Now fully up to date, this edition covers x-ray production and interactions, projection and tomographic imaging, image quality, radiobiology, radiation protection, nuclear medicine, ultrasound, and magnetic resonance-all of the important physics information you need to understand the factors that improve or degrade image quality. Covers the key information radiologists and radiologic technologists need to know to succeed on exams and perform their clinical duties Provides a high-yield, bullet-point review of this challenging field, mirroring the content found on the certification exam Includes 20 questions at the end of each chapter for immediate self-assessment, as well as two end-of-book exams with 100 questions each for a comprehensive review Includes only essential information needed to understand how images are created, aspects that impact image quality, and factors that affect radiation risks and costs Features full-color illustrations throughout, and helpful appendices such as summary of SI units, radiologic units, and photometric quantities An ideal physics review meant to be used in conjunction with a comprehensive textbook on medical imaging Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. "-- Provided by publisher.

Contents:
Foundations of Radiological Physics
X-Ray Imaging
Foundations of Image Quality
Patient Dosimetry
Radiation Risks
Radiation Protection
Radiography
Mammography
General Fluoroscopy
Interventional Radiology
Computed Tomography I
Computed Tomography II
Nuclear Medicine I
Nuclear Medicine II
Magnetic Resonance I
Magnetic Resonance II
Ultrasound I
Ultrasound I.

Summary: "This book remains focused on imaging using X-rays (i.e., projection radiography, fluoroscopy, and CT), as well as nuclear medicine, ultrasound, and MR"--Provided by publisher.

Contents:
X-rays
X-ray imaging
Image quality
Patient dosimetry
Radiation risks
Radiation protection
Radiography
Mammography
Fluoroscopy
Interventional radiology
CT I
CT II
Nuclear medicine I
Nuclear medicine II
Magnetic resonance I
Magnetic resonance II
Ultrasound I
Ultrasound II.

Contents:
[1] What people know, believe, and do about health.
[4] Patient education.
[6] School health education.

Contents:
Fundamentals / Michael A. Saidel, Ashley Rohr
Embryology and anatomy / Megan E. Collins
Optics / Kenneth Chern
Neuro-ophthalmology / Jeffrey Nichols
Pediatrics and strabismus / Megan E. Collins
Plastics / Marcus J. Ko, Wendy W. Lee
Pathology / Marcus Marcet
Uveitis / David M. Hinkle
Glaucoma / Shuchi Patel
Cornea / Kenneth Chern and Michael Saidel
Lens/cataract / Kenneth Chern and Edward Koo
Retina and vitreous / Alok Bansal, Rahul Khurana and Louis Chang.

Summary: Lucas Falcão Monteiro, Pault Yeison Minaya Ferruzo, Lilian Cristina Russo, Jessica Oliveira Farias, and Fábio Luís Forti: DUSP3/VHR: A Druggable Dual Phosphatase for Human Diseases Kep Yong Loh, Ziting Wang, and Ping Liao: Oncotic Cell Death in Stroke Martin Kolisek, Gerhard Sponder, Ivana Pilchova, Michal Cibulka, Zuzana Tatarkova, Tanja Werner, and Peter Racay: Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7 Amir Abbas Momtazi-Borojeni, Jafar Mosafer, Banafsheh Nikfar, Mahnaz Ekhlasi-Hundrieser, Shahla Chaichian, AbolfazlMehdizadehkashi, and Atefeh Vaezi: Curcumin in advancing treatment for gynecological cancers with developed drug- and radiotherapy-associated resistance Amir Abbas Momtazi-Borojeni, Jafar Mosafer, Banafsheh Nikfar, Mahnaz Ekhlasi-Hundrieser, Shahla Chaichian, AbolfazlMehdizadehkashi, and Atefeh Vaezi: Correction to: Curcumin in advancing treatment for gynecological cancers with developed drug- and radiotherapy-associated resistance.

Contents:
Intro; Contents; DUSP3/VHR: A Druggable Dual Phosphatase for Human Diseases; 1 Introduction; 2 Protein Tyrosine Phosphatase (PTP); 2.1 Dual-Specificity Phosphatase (DUSP); 2.2 ADUSP; 2.3 DUSP3/VHR; 3 Molecular and Biological Functions of DUSP3/VHR; 3.1 DUSP3 in Tumorigenesis; 3.2 DUSP3 in Genomic Stability; 3.3 DUSP3 in Blood-Associated Diseases; 4 Overview of Current Knowledge on DUSP3/VHR Inhibitors; 5 Conclusions; References; Oncotic Cell Death in Stroke; 1 Introduction; 2 Pathways of Sodium Influx in Stroke; 2.1 Na+/K+-ATPase; 2.2 Glutamate Receptor Channels 1 Introduction1.1 Toward the Identification of Mammalian/Human Mg2+ Transporters/Mg2+ Homeostatic Factors; 2 Novel Mammalian Magnesiotropic Genes Encode for Electrogenic Mg2+ Transporters (Channels) When Expressed in Xenopus laevis O ... ; 3 Expression Profiles of Novel Magnesiotropic Genes and Their Protein Products; 4 Cellular Compartmentalization and Functional Characterization of Proteins Encoded by the Putative and Confirmed Mg2+ Transpo ... ; 4.1 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Mitochondria 2.3 Acid-Sensing Ion Channels (ASICs)2.4 Na+/H+ Exchanger (NHE); 2.5 Electrogenic Na+/HC
O3- Co-transporter 1 (NBCe1); 2.6 Transient Receptor Potential (TRP) Channels; 3 Pathways of Chloride Influx in Stroke; 3.1 Na+-K+-2Cl- Co-transporter 1 (NKCC1); 4 Pathways of Potassium Efflux in Stroke; 4.1 KCNQ (Kv7) K+ Channels; 4.2 ATP-Dependent K+ Channels (KATP Channels); 5 Aquaporins (AQPs); 6 Mitochondrial Dysfunction; 7 Key Challenges and Future Directions; 8 Conclusion; References; Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7 4.2 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Endoplasmic Reticulum4.3 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to the Golgi Apparatus; 4.4 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Lysosomes; 4.5 Mg2+ Transport Across Nuclear Membrane; 4.6 Putative and Confirmed Mg2+ Transporters/Mg2+ Homeostatic Factors with Unclear Localization; 4.6.1 SLC41A2 (Solute Carrier Family 41 Member A2); 4.6.2 The CNNM (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator) Family, ``Enfant terrible ́́Among Mg2+ Transpo ... CNNM2 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 2)CNNM4 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 4); CNNM1 and CNNM3 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator3 and 4); 4.7 Putative and Confirmed Mg2+ Transporters/Mg2+ Homeostatic Factors with Plasma Membrane Localization; 4.7.1 SLC41A1 (Solute Carrier Family 41 Member A1); 4.7.2 KelI/XK; 4.7.3 NIPA1-NIPA4 (Non-imprinted in Prader-Willi/Angelman Syndrome 1-4)

Summary: The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.

Contents:
Intro; Preface; Contents; Contributors;
Chapter 1: Insulin Resistance in Schizophrenia; 1.1 Introduction; 1.2 Insulin Resistance and Metabolic Syndrome Associated with Antipsychotic Treatment; 1.3 Insulin Resistance in First Onset Antipsychotic Naive Schizophrenia Patients; 1.4 Effects of Insulin Resistance in Schizophrenia on Other Neuroendocrine Systems; 1.4.1 Growth Hormone; 1.4.2 Cortisol; 1.4.3 Gonadal Steroids; 1.4.4 Other Hormones; 1.5 Conclusions; References;
Chapter 2: Biogenesis of the Insulin Secretory Granule in Health and Disease; 2.1 Introduction; 2.2 Biosynthesis of Insulin 2.3 Secretion of the Insulin Secretory Granule Contents2.4 Insulin Secretory Granule Contents; 2.4.1 Chromogranin A; 2.4.2 PC1; 2.4.3 PC2; 2.4.4 CPH; 2.4.5 Other Insulin Secretory Granule Proteins; 2.5 Conclusions; References;
Chapter 3: Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions; 3.1 Introduction; 3.2 NASH Pathogenesis; 3.3 Diet-Induced Models; 3.3.1 High Fat Diet (HFD); 3.3.2 Modified High Fat Diets; 3.3.3 Methionine- and Choline-Deficient Diet (MCD); 3.4 Mechanistic Insights, Susceptibility Factorsand Interventions 3.4.1 Mitochondrial Stress3.4.2 Oxidative Stress; 3.4.3 Inflammation; 3.4.4 Gut-Liver Axis and Microbiome; 3.5 Animal Models to Study Developmental Origins of NAFLD; 3.5.1 Rodents; 3.5.2 Non-human Primates; 3.5.3 Other Models; 3.6 Brain-Liver Axis; 3.7 Conclusions; References;
Chapter 4: Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring; 4.1 Introduction; 4.1.1 Developmental Origins of Health and Disease; 4.1.2 The Importance of Preclinical Models; 4.1.3 Metabolic Effects on Reproductive Health; 4.2 Study Design 4.2.1 Animal Husbandry Guidelines4.2.2 Diets; 4.2.3 Preventing Bias; 4.2.4 Timing; 4.3 Animal Models; 4.3.1 Rodents; 4.3.2 Sheep; 4.3.3 Non-human Primates; 4.4 Models of Reproductive Dysfunction; 4.5 Early-Life Dietary Models and Reproductive Dysfunction; 4.5.1 Undernutrition; 4.5.1.1 Global Undernutrition; 4.5.1.2 Protein Restriction; 4.5.2 Maternal Overnutrition; 4.5.2.1 Single Source High-Fat Diet; 4.5.2.2 Other Single Nutrient Diets; 4.5.2.3 Cafeteria Diet; 4.5.3 Surgical Interventions; 4.6 Conclusions; References

Summary: Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.

Summary: Although anterior cruciate ligament (ACL) reconstruction has a high success rate, a substantial number of patients are left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique provides detailed strategies for planning and executing revision ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons cover the diagnosis of failed ACL reconstruction, patient evaluation, preoperative planning for revision ACL surgery, and complex technical considerations.

Contents:
Patient-related risk factors for ACL graft failure
Avoiding the failed ACL: how to prevent ACL tears before they occur
Diagnosis of failed ACL reconstruction
Biomechanics and Etiology of ACL graft failure
Technical causes of ACL graft failure
Indications for revision ACL reconstruction
Preoperative planning for revision ACL reconstruction
Graft selection for revision ACL reconstruction
How to handle a poorly placed femoral tunnel
How to handle a poorly placed tibial tunnel
Fixation in revision ACL reconstruction
Single stage ACL revision reconstruction: indications and technique
Two stage ACL revision: indications and technique
Revising failed double-bundle ACL reconstruction
The role of lateral extra-arcticular augmentation in revision ACL reconstruction
Managing the infected ACL reconstruction
Meniscus allograft transplantation in revision ACL reconstruction
Cartilage surgery in revision ACL reconstruction
Medial collateral ligament laxity in revision ACL reconstruction
Posterolateral corner deficiency in revision ACL reconstruction
Osteotomy for slope correction following failed ACL reconstruction
Osteotomy for malalignment following failed ACL reconstruction
Navigation for revision ACL reconstruction
Approach to the multiply revised ACL knee
Outcomes of revision ACL.

Summary: Anterior cruciate ligament reconstruction is one of the most common procedures performed in sports medicine centers. However, these procedures can carry a long-term failure rate as high as 5-15%%, and when these procedures fail, revision is significantly more complex. Considerable factors need to be assessed in patients that are indicated for surgery, as revisions carry a higher failure rate and potentially less optimal outcomes and return to sport and activity. These factors include, but are not limited to, the status of the meniscus, overall alignment, graft options, placement of prior implants or tunnels, collateral ligament quality, and whether or not the revision must be staged into two procedures. This text provides a comprehensive, case-based presentation of the most efficient and practical treatment algorithms for patients in need of revision ACL repair and reconstruction. Opening chapters discuss the initial patient work-up, radiography, surgical indications, graft options, and pre-operative considerations and preparations. The main portion of the book then describes both common factors leading to revision surgery as well as the surgical techniques themselves, illustrated via plentiful operative photos and vivid clinical case material. The management of osteolysis, ligamentous laxity, extra-articular tenodesis, plane correction, and meniscus deficiency, among others, are discussed in detail. Special populations, such as the pediatric patient, the elite athlete and the female athlete, are discussed as well. Shedding light on this challenging surgical repair, Revision Anterior Cruciate Ligament Reconstruction is the go-to resource for sports medicine and orthopedic surgeons, knee specialists and residents and fellows in these areas. .

Contents:
Initial Work-up of the Failed ACL Reconstruction
Radiographic Work-up of the Failed ACL Reconstruction
Indications for Revision ACL Reconstruction
Graft Options in the Revision ACL Setting
Management of the Structurally Intact ACL with Residual Instability
Management of Osteolysis in Revision ACL
Prior Femoral Tunnel Management
Prior Tibial Tunnel Management
Indications for Two-stage Revision ACL Reconstruction
Management of Medial Sided Ligamentous Laxity
Management of Lateral Sided Ligamentous Laxity
Management of Sagittal Plane Deformity
Role of High Tibial Osteotomy to Restore Coronal Balance
Role of Extra-articular Tenodesis: ITB
Role of Extra-articular Tenodesis: ALL
Management of the Medial Meniscus-deficient Knee
Management of the Lateral Meniscus-deficient Knee
Management of the Stiff Failed ACL Reconstruction
Management of the Failed Pediatric ACL Reconstruction
Concomitant Chondral Restoration
Management of the Elite Athlete with a Failed ACL Reconstruction
Outcomes after Revision ACL Reconstruction.

Summary: Offering in-depth coverage of an often-neglected topic, Revision Lumbar Spine Surgery identifies clinical problems and discusses recent major advances in this challenging area. Dr. Robert F. Heary and a team of international experts share their knowledge and experience with even the most difficult lumbar cases, helping you provide optimal outcomes for your patients. You'll find authoritative guidance on indications, diagnosis, approaches, and follow-up, with a focus on the significant advances that have occurred over the past two decades in this fast-changing field. Identifies the clinical problems related to unsuccessful back spine surgery as well as indications, diagnosis, and new treatment options and advances in this complex area. Provides in-depth information on the multiple options that exist for most clinical situations: anterior, posterior, lateral, and combined anterior and posterior approaches. Covers methods of fixation, the use of interbody grafting, and surgical planning related to scar tissues, bleeding, and spinal fluid leaks. Discusses critical follow-up topics such as key clinical procedures, radiography, patient reported outcomes, and pain management. Includes timely chapters on robotics, bone density issues, medical fitness concerns, instrumentation options, imaging considerations, and much more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Contents:
Intro
Preface
Acknowledgments
Contents
Contributors
Part I: Forefoot
1: Revision of Failed 1st MTPJ Fusion
Introduction
Evaluation and Assessment
Surgical Planning
Case Examples
Case 1.1 Failed 1st MTPJ Fusion After Implant Arthroplasty
History
Reasons for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Case 1.2 Malunion of a 1st MTPJ Fusion
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Case 1.3 Nonunion of 1st MTPJ Fusion
History
Reasons for Failure
Surgical Plan Approach
Implants
Case 1.4 Nonunion of 1st MTPJ Fusion
History
Reasons for Failure
Surgical Plan
Approach
Implants
Summary
References
2: Management of Failed Hallux Valgus
Introduction
Evaluation
Recurrence
Introduction
Causes of Failure
Evaluation and Surgical Planning
Cases
Case 2.1
History
Reason Case Failed
Surgical Plan
Approach
Implants
Case 2.2
History
Reason Case Failed
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Hallux Varus
Introduction
Causes of Failure Evaluation and Surgical Planning
Cases
Case 2.3
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Malunion
Introduction
Causes of Failure
Evaluation
Surgical Planning
Dorsiflexion Malunion
Shortening Malunion
Cases
Case 2.4
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfall
Case 2.5
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Postoperative Care
Avascular Necrosis
Introduction and Causes of Failure Evaluation
Surgical Planning
Cases
Case 2.6
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
Nonunion
Introduction and Causes of Failure
Evaluation
Surgical Planning
Cases
Case 2.7
History
Reason for Failure
Surgical Plan
Approach
Implants
Pearls and Pitfalls
References
3: Revision Intermetatarsal Neurectomy
The Problem: Recurrent Intermetatarsal Neuroma
Causes for Failure
Differential Diagnosis Includes
Clinical Evaluation of Pathology (History) Clinical Evaluation of Pathology (Physical)
Radiologic Studies
Nonoperative Options
Operative Options
Surgical Planning
Contraindications and Precautions
Goals of Procedure
Advantages
Key Principles
Preoperative Preparation and Patient Positioning
Positioning
Operative Technique
Dorsal Approach
Plantar Approach (Preferred for Recurrence due to True Stump Neuroma)
Tips and Pearls
Hazards and Pitfalls
Complications/Bailout/Salvage
Postoperative Care
Outcomes
Case Examples
Case 3.1
History
Physical Examination
Reasons for Failure

Summary: This comprehensive book is devoted to revision total joint arthroplasty and provides state-of-the-art guidance in a field where level-I evidence is difficult to produce. In the books respective sections, each of which focuses on a specific joint - the knee, hip, shoulder, elbow, or ankle - readers will learn how to manage these complex surgical techniques. Each section thoroughly describes the epidemiology, causes and surgical techniques, as well as clinical results and complications. Filling an important gap in a rapidly evolving field, this book will appeal to all healthcare workers involved in the care of affected patients, including orthopedic surgeons and fellows, rehabilitation specialists, pain physicians, podiatrists and nurses.

Contents:
I Revision Knee Arthroplasty
1 Revision knee arthroplasty: epidemiology and causes
2 Revision knee arthroplasty: surgical technique
3 Revision knee arthroplasty: complications and results
II Revision Hip Arthoplasty
4 Revision hip arthroplasty: epidemiology and causes
5 Revision hip arthroplasty: surgical technique
6 Revision hip arthroplasty: complications and results
III Revision Shoulder Arthroplasty
7 Revision shoulder arthroplasty: epidemiology and causes
8 Revision shoulder arthroplasty: surgical technique
9 Revision shoulder arthroplasty: complications and results
IV Revision Elbow Arthroplasty
10. Revision elbow arthroplasty: epidemiology and causes
11 Revision elbow arthroplasty: surgical technique
12. Revision elbow arthroplasty: complications and results
V Revision Ankle Arthroplasty
13 Revision ankle arthroplasty: epidemiology and causes
14 Revision ankle arthroplasty: surgical technique
15 Revision ankle arthroplasty: complications and results.

Summary: This book is a practically applicable guide to the use of revision total knee arthroplasty. Demand for primary total knee arthroplasty (TKA) continues to rise, with some estimates predicting this to be as high as 400% than it currently is, and this will inevitably lead to increased demand for revision surgery. Furthermore, this is a sub-specialist area of arthroplasty that is complex and challenging with high failure rates, meaning that there is a real need to improve the outcomes of these procedures. Within this book, the chapters focus on a particular subject area focusing on how to successfully perform a procedure in a step-by-step manner in a variety of scenarios from condylar revisions to salvage cases. Topics covered include how to use surgical techniques in instances of periprosthetic distal femur fractures and manage infections where bone loss has been significant. Long-term outcome data is also presented to enable the reader to develop a deep understanding of where a particular strategy might be most effective. Revision Total Knee Arthroplasty: A Practical Guide concisely details how to use the techniques covered in all aspects of revision knee surgery, making it an indispensable resource for all those involved in the care of these patients or who use these techniques in their day-to-day clinical practice.

Contents:
Philosophy of primary Total Knee Arthroplasty: Back to the Beginnings
Complex Primary Total Knee Arthroplasty
Assessment of Painful Total Knee Arthroplasty
Indications for Revision Total Knee Arthroplasty
Challenges of Surgical Exposure
Removal of Well-Fixed Components
Principles of Surgical Reconstruction: Back to the Beginnings& gain
Fixation in Revision Total Knee Arthroplasty
Kinematics of Constrained Condylar Revision Implants: Practical Perspective
Rotating Hinge Implants
Salvage Revision Total Knee Arthroplasty
Managing Infection in Revision Total Knee Arthroplasty: Practical Perspective
Orthoplastics and Revision Knee Arthroplasty
Managing Chronic Patella Dislocations in Revision Knee Arthroplasty: Surgical Technique
Extensor Mechanism Failure and Allograft Reconstruction
Periprosthetic Distal Femur Fractures: Arthroplasty Perspective
Mortality in Revision Knee Arthroplasty
Starting a Career as a Revision Knee Surgeon- Benjamin Bloch
Lifetime of Revision Knee Arthroplasty
Lifetime of Revision Knee Arthroplasty.

Summary: This book is divided into 3 parts, each containing chapters that cover commonly encountered clinical scenarios of reoperative surgery. These parts include revisional bariatric surgery, reoperation for complications of bariatric surgery, and revisional anti-reflux and gastric procedures. The information covered discusses existing literature and best-practices in patient care, with a focus on operative technique, pitfalls, and post-operative complications. The aim of this book is to provide the reader with information on how to successfully manage a patient requiring reoperation. Chapters also highlight the difference in patient outcomes when the procedures are completed in a minimally invasive approach rather than an open approach. Revisional Foregut Surgery serves as a valuable resource for medical students, surgical residents, fellows, and attending surgeons seeking advice and guidance on reoperative upper gastrointestinal surgery and their related complications.

Contents:
Revision of the Laparoscopic Gastric Band
Revisional Surgery for Sleeve Gastrectomy
Gastric Bypass Reversal
Management of Banded Gastric Bypasses: Revisional Bariatric Surgery after a Fobi-Capella Banded Gastric Bypass
Revision of Vertical Banded Gastroplasty
Laparoscopic Adjustable Gastric Band Complications
Sleeve Gastrectomy Complications
Gastric Bypass Complications
Reoperative Anti-Reflux Surgery and Revisional Paraesophageal Hernias
Postgastrectomy Syndromes
Intraoperative Endoscopy During Revisional Foregut Surgery
Who to Scope?
Revisional Foregut Surgery in the Pediatric Patient.

Summary: This book provides an up-to-date overview of shelf acetabuloplasty, a traditional procedure for acetabular dysplasia. Originally, shelf acetabuloplasty was mainly intended for the treatment of developmental dysplasia of the hip (DDH) in children and adolescents. However, secondary osteoarthritis of the hip due to DDH is more common than primary osteoarthritis, and shelf acetabuloplasty was subsequently applied to such cases in adults. Recently, periacetabular pelvic osteotomies, such as the rotational acetabular osteotomy have established themselves and are broadly indicated as joint-preserving operations for secondary hip osteoarthritis. With the increased interest in pelvic osteotomies, the role of shelf acetabuloplasty as a reliable and safe procedure now needs to be redefined. Each chapter was prepared by an expert in his or her field. The authors highlight the essence of the indication, discuss advanced and cutting-edge techniques, and assess the outcomes of shelf acetabuloplasty. Taken together, they provide a valuable contribution to hip surgery.

Summary: Through a global and interdisciplinary lens, this book discusses, analyzes and summarizes the novel conservation approach of rewilding. The volume introduces key rewilding definitions and initiatives, highlighting their similarities and differences. It reviews matches and mismatches between the current state of ecological knowledge and the stated aims of rewilding projects, and discusses the role of human action in rewilding initiatives. Collating current scholarship, the book also considers the merits and dangers of rewilding approaches, as well as the economic and socio-political realities of using rewilding as a conservation tool. Its interdisciplinary nature will appeal to a broad range of readers, from primary ecologists and conservation biologists to land managers, policy makers and conservation practitioners in NGOs and government departments. Written for a scientifically literate readership of academics, researchers, students, and managers, the book also acts as a key resource for advanced undergraduate and graduate courses.

Contents:
1. Rewilding : a captivating, controversial, twenty-first-century concept to address ecological degradation in a changing world / Nathalie Pettorelli, Sarah M. Durant, Johan T. du Toit
2. History of rewilding : ideas and practice / David Johns
3. For wilderness or wildness? : decolonising rewilding / Kim Ward
4. Pleistocene rewilding : an enlightening thought experiment / Johan T. du Toit
5. Trophic rewilding : ecological restoration of top-down trophic interactions to promote self-regulating biodiverse ecosystems / Jens-Christian Svenning, Michael Munk, Andreas Schweiger
6. Rewilding through land abandonment / Steve Carver
7. Rewilding and restoration / James R. Miller, Richard J. Hobbs
8. Understanding the factors shaping the attitudes towards wilderness and rewilding / Nicole Bauer, Aline von Atzigen
9. Health and social benefits of living with 'wild' nature / Cecily Maller, Laura Mumaw, Benjamin Cooke
10. The psychology of rewilding / Susan Clayton
11. The high art of rewilding : lessons from curating earth art / Marcus Hall
12. Rewilding a country : Britain as a study case / Christopher J. Sandom, Sophie Wynne-Jones
13. Bringing back large carnivores to rewild landscapes / John D.C. Linnell, Craig R. Jackson
14. Rewilding cities / Marcus Owens, Jennifer Wolch
15. The role of translocation in rewilding / Philip J. Seddon, Doug P. Armstrong
16. Top-down control of ecosystems and the case for rewilding : does it all add up? / Matt W. Hayward, Sarah Edwards, Bronwyn A. Fancourt, John D.C. Linnell, Erlend B. Nilsen
17. Rewilding and the risk of creating new, unwanted ecological interactions / Miguel Delibes-Mateos, Isabel C. Barrio, A. Márcia Barbosa, Íñigo Martínez-Solano, John E. Fa, Catarina C. Ferreira
18. Auditing the wild : how do we assess if rewilding objectives are achieved? / Richard T. Corlett
19. Adaptive co-management and conflict resolution for rewilding across development contexts / James R.A. Butler, Juliette C. Young, Mariella Marzano
20. The future of rewilding : fostering nature and people in a changing world / Sarah M. Durant, Nathalie Pettorelli, Johan T. du Toit.

Summary: This book highlights the recent developments on rhamnolipid biosurfactant, its properties, role on the natural environment and various applications. Recently, it has shown promising application in Environment, Agriculture, food, petroleum, and pharmaceutical industries due to its environment-friendly and easily degradable nature. The book emphasizes on the various techniques that are utilized for the detection and isolation of rhamnolipid biosurfactant from microorganisms. It highlights the various aspects of the rhamnolipid biosurfactants including structural characteristics, production, and its application. The book presents the current knowledge and the latest advances in the function-based metagenomics strategies to facilitate the exploration of the novel biosurfactants.

Contents:
Rhamolipid biosurfactants and their properties
Extraction, detection, and characterization of rhamnolipid biosurfactants from microorganisms
Production of rhamnolipids
Advancement of genetic engineering in rhamnolipid(s) production
Environmental applications of rhamnolipids
Industrial applications of rhamnolipid : an innovative green technology for industry
Application of rhamnolipids in medical science
Role of rhamnolipids in enhanced oil recovery and oil industry
Application of rhamnolipids in agriculture and food industry
Rhamnolipid-assisted synthesis of stable nanoparticles : a green approach
Quorum sensing : its role in rhamnolipid production
Future prospects and scenario of rhamnolipids.

Summary: This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

Contents:
Aging and rheumatology
Prevalence and significance of rheumatic conditions in geriatric population
Musculoskeletal system in elderly
Immune system in elderly
Pharmacokinetics and anti-rheumatic drugs in elderly
Non Steroidal AntiInflammatory Drugs
Synthetic Disease Modifying anti-Rheumatic Drugs
Biological Disease Modifying anti-Rheumatic Drugs
Glucocorticosteroids
Opiates and Cannabis
Comorbidities of rheumatic diseases in geriatric patients
Cardiovacular
Pulmonary
Osteoporosis
Ophtalmologic
Vaccination of elderly patients with rheumatic diseases
Laboratory diagnostics of rheumatic diseases in elderly
Musculoskeletal imaging in geriatric patients
Rheumatic disorders in elderly
Rheumatoid arthritis
Systemic lupus erythematosus
Systemic sclerosis, Sjogrens syndrome and other systemic autoimmune diseases
Gout
Calcium pyrophosphate dehydrate deposition disease
Osteoarthritis
Giant cell arteritis
Polymyalgia rheumatic
Spondyloarthritis
Septic arthritis
Autoinflammatory diseases
Fibromyalgia
Rheumatic conditions related to malignancies and their treatment
Approach to a geriatric patient with suspected rheumatic condition
Approach to a geriatric patient with monoarthritis
Approach to a geriatric patient with polyarthritis
Approach to a geriatric patient with shoulder pain
Approach to a geriatric patient with widespread pain
Approach to a geriatric patient with intractable back pain
Approach to a geriatric patient with suspected myopathy
Approach to a geriatric patient with suspected vasculitis
Approach to a geriatric patient in pain clinic
Rehabilitation of an elderly patient with rheumatic disorder.

Summary: With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk-benefit ratios when managing patients with rheumatic irAE. Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

Contents:
Part I. Introduction. Cancer Immunology and the evolution of immunotherapy ; Cancer immunotherapy: overview of immune checkpoint inhibitors ; Immunopathogenesis of immune-related adverse events from cancer immunotherapy
Part II. Immune-related adverse events with immune-checkpoint inhibitors. Arthritis ; Polymyalgia rheumatica ; Myositis ; Sicca syndromes ; Sarcoidosis ; Miscellaneous rheumatic syndromes ; Non-rheumatic immune-related adverse events ; Immune-related adverse events with other cancer immunotherapies
Part III. Cancer immunotherapy in patients with pre-existing rheumatic diseases. Inflammatory arthritis ; Other rheumatic autoimmune diseases
Part IV. General principles of management. Management of rheumatic immune-related adverse events (irAEs): general principles ; Benefit-risk considerations ; Patient education and shared-decision making.

Summary: Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.

Summary: Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases.

Summary: Current texts in rheumatology are very detailed and designed specifically for rheumatologists. This clear and concise guide is targeted at the busy clinician who comes into contact with both common and uncommon rheumatologic disorders. Many chapters presents a common clinical scenario and include a definition of the disease while outlining incidence and prevalence, common manifestations, treatment and pitfalls. A range of topics are included in the fifteen chapters including osteoarthritis, rheumatoid arthritis, fibromyalgia, metabolic bone disease, gout and scleroderma, among others. Written by experts in the field, Rheumatology for Primary Care Providers is a definitive guide to rheumatology for the primary care physician and non-specialist.

Contents:
An Approach to a Patient with Joint Pain
Osteoarthritis
Rheumatoid arthritis
SLE for Primary Care Providers
Fibromyalgia for the Primary Care Physician
Metabolic Bone Disease and Osteoporosis
Crystal-Induced Arthritis
Overuse Injuries
Systemic and Localized Inflammatory Diseases of Older Adults
Interpretation of Rheumatological Tests
Infectious Arthritis
Autoinflammatory Disease
Scleroderma
Vasculitis
Ankylosing Spondylitis.

Summary: The premier resource for the practicing rheumatology nurse, Rheumatology Nursing: Scope and Standards of Practice, 2nd Edition, is informed by the advances in health care and professional nursing today. This new edition of the publication contains information on core role accountabilities, role qualifications, ethics in rheumatology nursing, along with trends, issues and opportunities that every rheumatology nurse must know.

Summary: This comprehensive book thoroughly covers the spectrum of rhinitis conditions and related comorbidities. Rhinitis and Related Upper Respiratory Conditions is a unique resource that delivers essential clinical information, addressing the varying patient populations which might be encountered in different types of clinical settings. Chapters range from topics such as pediatric, adult, geriatric, and occupational rhinitis, while also covering the full array of rhinitis subtypes and their complications. Later chapters address secondary causes of rhinitis such as systemic diseases manifesting as rhinitis, drug-induced rhinitis, and CSF leak. Written by experts in the field, every chapter is structured to contain clinical cases which illustrate the typical patient presentation, and their diagnostic work-up and treatment, providing the knowledge needed to further improve diagnosis and care for the patient with rhinitis. Rhinitis and Related Upper Respiratory Conditions is an ideal resource for allergists, primary care physicians, and health care extenders, to help them recognize and further improve care of patients with rhinitis.

Summary: This book is the most comprehensive (and possibly the first) manual on Rhino-Orbito-Cerebral Mucormycosis (ROCM) that covers mucormycosis of the nose extending to sinuses, orbit, and brain, all in. This volume covers the surge of cases during the COVID-19 pandemic, early identification and causative factors, microbiology, pathology and radiology, and the clinical presentation. Notes on surgical approaches, extent, and techniques of debridement, number of sittings, antifungal therapy, complications, and their management equip readers to manage these cases confidently. Detailed descriptions of ROCM surgery accompanied by nearly 500 photographs and anatomical drawings help support diagnostic and surgical decision-making. Also included is information on various specifications of MRI that help in achieving a perfect surgical clearance. The book includes chapters on debates on salvaging the orbit in ROCM, various situations, their management, the extent of resection, antifungal dosage and duration, prognostication of the patient, and postoperative care. The book assists surgeons in gaining the skills to perform endoscopic clearance of difficult areas like pterygoplataine fossa, infratemporal fossa, pterygoid plates, and the lacrimal drainage system, which offers significant advantages in terms of avoiding postoperative morbidity as compared to an external route. Since the external route is required in the most extensive form of the disease, the book has also covered it extensively. This book is an indispensable resource for otorhinolaryngologists, ophthalmic surgeons, ophthalmic plastic surgeons, physicians, microbiologists, pathologists, radiologists, neurosurgeons, faciomaxillary surgeons and junior and senior consultants optometrists and students.

Summary: This book offers a selection of pertinent patient case-presentations in the field of Rhinology, Anterior Skull Base and Facial Plastics surgery. It further explores the evidence-based management of simple to complex clinical presentations. Each chapter start with the diagnosis and progresses from medical or surgical treatment to the post-operative follow up of the presented clinical condition. The various case reports are concise; however, sufficiently comprehensive and cover conditions from emergencies in adult and paediatric rhinology, to elective care, sino-nasal and anterior skull base neoplasms systemic diseases affecting the nose and paranasal sinuses, and underpinned by illustrations, imaging, and intra-operative photographs to emphasize the clinical approach. Rhinology and Anterior Skull Base Surgery - A Case-based Approach is a highly informative and carefully presented book, providing insights for exam candidates, trainees, general practitioners, rhinologists and otolaryngologists with an interest in anterior skull base, facial plastics and rhinology.

Contents:
Introduction
Emergencies in Rhinology
Rhinitis
Rhinosinusitis
Facial plastics
Anterior skull base surgery.-Sinonasal tumours.-Paediatric rhinology
Olfactory disorders
Systematic diseases affecting the nose and the paranasal sinuses
General rhinology
Post- operative complications.