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Books

  • Digital/Print
    edited by Maria Diakonova, PhD.
    Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
    Digital Access  Springer 2015
  • Digital/Print
    Robert E. Anderson, Matthew M. LaVail and Joe G. Hollyfield, editors.
    Digital Access  Springer 2008
  • Digital
    Jasmine H. Francis, David H. Abramson, editors.
    Digital Access  Springer 2015
  • Digital
    Christos G. Athanassiou, Frank H. Arthur, editors.
    "This book aims to assess, evaluate and critically analyze the methods that are currently available for a judicious pest management in durable food. It presents and analyzes a vast amount of methods that are already in use in "real world" industrial applications. After the phase-out of methyl bromide, but also the withdrawal of several insecticides and the continuously updated food safety regulations, there is a significant knowledge gap on the use of risk-reduced, ecologically-compatible control methods that can be used with success against stored-product insect species and related arthropods. The importance of integrated pest management (IPM) is growing, but the concept as practiced for stored products might differ from IPM as historically developed for field crops. This book discusses a wide variety of control strategies used for stored product management and describes some of the IPM components. The editors included chemical and non-chemical methods, as both are essential in IPM. They set the scene for more information regarding emerging issues in stored product protection, such as emerging, alien and invasive species as threats for global food security, as well as the importance of stored-product arthropods for human health. Finally, the analysis of the economics of stored product protection is presented, from theory to practice."-- Provided by publisher.
    Digital Access  Springer 2018
  • Digital
    edited by Francisco Fernández-Avilés.
    Digital Access  Oxford 2008
  • Digital
    volume editor, Kosaku Nitta.
    The role of caveolae on albumin passage through glomerular endothelial and epithelial cells : the new etiology of urinary albumin excretion / Moriyama, T.; Karasawa, K.; Nitta, K. (Tokyo) -- Rituximab as a therapeutic option for steroid-sensitive minimal change nephrotic syndrome in adults / Iwabuchi, Y; Moriyama, T.; Itabashi, M.; Takei, T.; Nitta, K. (Tokyo) -- Large renal corpuscle: clinical significance of evaluation of the largest renal corpuscle in kidney biopsy specimens / Kataoka, H.; Mochizuki, T.; Nitta, K. (Tokyo) -- New insights into cystic kidney diseases / Mochizuki, T.; Makabe, S.; Aoyama, Y.; Kataoka, H.; Nitta, K. (Tokyo) -- Recent advances in the treatment of lupus nephritis / Karasawa, K.; Uchida, K.; Takabe, T.; Moriyama, T.; Nitta, K. (Tokyo) -- Association between increases in normalized protein catabolic rate and increases in creatinine generation rate in dialysis patients / Hanafusa, N.; Kamei, D.; Tsukada, M.; Miwa, N. (Tokyo); Komatsu, M.; Shiohira, S.; Okazaki, M.; Kawaguchi, H. (Fukushima); Tsuchiya, K.; Nitta, K. (Tokyo) -- Renal anemia and iron metabolism / Ogawa, C. (Kawasaki); Tsuchiya, K. (Kawasaki/Tokyo); Maeda, K. (Kawasaki); Nitta, K. (Tokyo) -- Cell sheet engineering and kidney diseases / Oka, M.; Miyabe, Y.; Sugiura, N.; Nitta, K. (Tokyo) -- Clinical impact of left ventricular diastolic dysfunction in chronic kidney disease / Ogawa, T. (Tokyo) -- Treatment of posttransplantation anemia / Unagami, K.; Okumi, M.; Tamura, T.; Ishida, H.; Tanabe, K.; Nitta, K. (Tokyo) -- Role of frailty on outcomes of dialysis patients / Nitta, K.; Hanafusa, N.; Tsuchiya, K. (Tokyo) -- Socioeconomics of administering rituximab for nephrotic syndrome / Takura, T.; Takei, T.; Nitta, K. (Tokyo) -- Use of beta-blockers on maintenance dialysis patients and ischemic cerebral and cardiovascular deaths: an examination using propensity score / Omae, K; Ogawa, T.; Yoshikawa, M.; Sakura, H.; Nitta, K. (Tokyo) -- Direct effects of immunomodulatory agents on podocytes in immune-mediated glomerular diseases / Manabe, S. (Tsukuba/Tokyo); Nitta, K. (Tokyo); Nagata, M. (Tsukuba).
    Digital Access  Karger 2018
  • Digital
    Hideyuki Ishida, Keiji Koda, editors.
    Digital Access  Springer 2019
  • Digital
    edited by Katarzyna Chojnacka, Agnieszka Saeid.
    Introduction / Katarzyna Chojnacka -- Historical Aspects / Henryk Górecki, Katarzyna Chojnacka -- Modern Analytical Methods of Speciation and Determination of Trace Elements in Inorganic, Organic, and Biological Samples / Bogusław Buszewski, Wojciech Piekoszewski, Paweł Pomastowski, Katarzyna Rafińska, Mateusz Sugajski, Tomasz Kowalkowski -- Trace Elements in the Environment -- Law, Regulations, Monitoring and Biomonitoring Methods / Elżbieta Maćkiewicz, Aleksandra Pawlaczyk, Małgorzata Iwona Szynkowska -- Problems of Trace Elements in Water and Wastewater Treatment / Karol Pokomeda, Anna Dawiec-Liśniewska, Daria Podstawczyk, Macarena Rodriguez-Guerra Pedregal, Barbara Ortega Barcelo, Anna Witek-Krowiak -- Trace Elements in Agricultural and Industrial Wastes / Aneta Wiśniewska, Agnieszka Saeid, Katarzyna Chojnacka -- Trace Elements in Aquatic Environments / Piotr Konieczka, Bartłomiej Cieślik, Jacek Namieśnik -- Trace Metals in Soils / Philiswa N Nomngongo, Joseph M Matong, Tshimangandzo S Munonde -- The Role of Trace Elements in Living Organisms / Elżbieta Gumienna-Kontecka, Magdalena Rowińska-Żyrek, Marek Łuczkowski -- Fluorine and Silicon as Essential and Toxic Trace Elements / Izabela Michalak, Katarzyna Chojnacka -- Biological Functions of Cadmium, Nickel, Vanadium, and Tungsten / Agnieszka Dmytryk, Łukasz Tuhy, Mateusz Samoraj, Katarzyna Chojnacka -- Biosorption of Trace Elements / Inga Zinicovscaia -- Bioaccumulation and Biomagnification of Trace Elements in the Environment / Małgorzata Iwona Szynkowska, Aleksandra Pawlaczyk, Elżbieta Maćkiewicz -- Hydrometallurgy and Bio-crystallization of Metals by Microorganisms / Zygmunt Sadowski, Agnieszka Pawlowska -- Trace Elements as Fertilizer Micronutrients / Izabela Michalak, Agnieszka Saeid, Katarzyna Chojnacka, Mateusz Gramza -- Trace Elements in Animal Nutrition / Łukasz Tuhy, Agnieszka Dmytryk, Mateusz Samoraj, Katarzyna Chojnacka -- Trace Elements in Human Nutrition / Klaudia Konikowska, Anna Mandecka -- Trace Elements in Human Health / Renata Mozrzymas -- Spirulina as a Raw Material for Products Containing Trace Elements / Liliana Cepoi, Tatiana Chiriac, Ludmila Rudi, Svetlana Djur, Liliana Zosim, Valentina Bulimaga, Ludmila Batir, Daniela Elenciuc, Valery Rudic -- Dietary Food and Feed Supplements with Trace Elements / Athanasios C Pappas, Katarzyna Godlewska, Peter F Surai -- Biofortification of Food with Trace Elements / Mateusz Samoraj, Łukasz Tuhy, Agnieszka Dmytryk, Katarzyna Chojnacka -- Biomarkers of Trace Element Status / Katarzyna Chojnacka, Marcin Mikulewicz -- Human Exposure to Trace Elements from Dental Biomaterials / Marcin Mikulewicz, Katarzyna Chojnacka -- Industrial Use of Trace Elements and their Impact on the Workplace and the Environment / Piotr Rusek, Marzena Mikos-Szymańska -- Speciation of Trace Elements and its Importance in Environmental and Biomedical Sciences / Aleksandra Pawlaczyk, Elżbieta Maćkiewicz, Małgorzata Iwona Szynkowska -- Trace Elements -- A Threat or Benefit? / Katarzyna Chojnacka, Izabela Michalak, Agnieszka Saeid, Katarzyna Godlewska, Łukasz Tuhy, Mateusz Samoraj, Agnieszka Dmytryk, Aneta Wiśniewska.
    Digital Access  Wiley 2018
  • Digital
    Samantha J. Richardson, Vivian Cody [editors].
    Digital Access  Springer 2009
  • Digital
    Akihiko Kato, Eiichiro Kanda, Yoshihiko Kanno, editors.
    Digital Access  Springer 2020
  • Digital/Print
    Eleftherios Mylonakis, Frederick M. Ausubel, Michael Gilmore, Arturo Casadevall, editors.
    Amoeba provide insight into the origin of virulence in pathogenic fungi / Arturo Casadevall -- Of model hosts and man: using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as model hosts for infectious disease research / Justin Glavis-Bloom, Maged Muhammed, and Eleftherios Mylonakis -- Caenorhabditis elegans as an alternative model to study senescence of host defense and the prevention by immunonutrition / Tomomi Komura ... [et al.] -- Bacterial effectors: learning on the fly / Laurent Boyer ... [et al.] -- Drosophilia asthma model: what the fly tells us about inflammatory diseases of the lung / Thomas Roeder ... [et al.] -- Elucidating the in vivo targets of Photorhabdus toxins in real-time using Drosophilia embryos / Isabella Vlisidou, Nicholas Waterfield, and Will Wood -- Ecological niche modeling as a tool for understanding distributions and interactions of vectors, hosts, and etiologic agents of Chagas disease / Jane Costa and A. Townsend Peterson -- Where simplicity meets complexity: Hydra, a model for host-microbe interactions / René Augustin ... [et al.] -- Tick as a model for the study of primitive complement system / Petr Kopacek, Ondrej Hajdusek, and Veronika Buresova -- Model hosts for the study of oral candidiasis / Juliana Campos Junqueira -- Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock / Yongqing Li and Hasan B. Alam.
    Digital Access  Springer 2012
  • Digital
    Shabir Hussain Wani, editor.
    This edited volume summarizes the recent advancements made in plant science including molecular biology and genome editing, particularly in the development of novel pathways tolerant to climate change-induced stresses such as drought, extreme temperatures, cold, salinity, flooding, etc. These stresses are liable for decrease in yields in many crop plants at global level. Till date conventional plant breeding approaches have resulted in significant improvement of crop plants for producing higher yields during adverse climatic conditions. However, the pace of improvement through conventional plant breeding needs to be accelerated in keeping with the growing demand of food and increasing human populationl, particularly in developing world. This book serves as a comprehensive reference material for researchers, teachers, and students involved in climate change-related abiotic stress tolerance studies in plants.
    Digital Access  Springer 2019
  • Digital
    Digital Access  
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  • Digital
    Deborshi Sharma, Priya Hazrah, editors.
    The book covers the recent developments in various aspects of minimal access surgery (laparoscopic and robotic surgery), which is fairly a new branch of surgery that has advanced tremendously in last few years. This is the first volume of the set of books on recent concepts in minimal access surgery. It provides step-by-step descriptions accompanied by numerous helpful photographs and anatomical drawings. It also includes the controversies and gives a cumulative opinion on the recent changes developing in minimal access surgery (MAS). It includes system wise topics and separate chapters on the different topics within the system with the meta-analysis of recent topic or their controversies. The book is useful for practitioners and young faculties as well as residents, trainees and fellows of surgery and minimal access surgery.
    Digital Access  Springer 2022
  • Digital
    Arti Gupta, Nagendra Pratap Singh, editors.
    Fungal growths affect both human and animal well-being. Many natural pathogens of laboratory animals alter host physiology, rendering the host unsuitable for experimental uses. While the number and prevalence of few pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using laboratory animals in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. What does the future hold regarding the natural pathogens of laboratory animals? The selection of an animal model must carefully address issues of the type of human disease to mimic, the parameters to follow, and the collection of the appropriate data to answer those questions being asked. Overall, animal models of fungal infection will continue to deepen our understanding of how these infections occur. This book provides a valuable source of information to biological and biomedical scientists and to clinical and doctoral researchers working in the area of fungal infections and diseases of laboratory animal species.
    Digital Access  Springer 2019
  • Digital
    Jagdish N. Sharma, editor.
    Basic and clinical aspects of bradykinin receptor antagonists -- The kallikrein-kinin pathways in hypertension and diabetes -- Tissue Kallikrein-kinin therapy in hypertension and organ damage -- Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension -- The Kallikrein-kinin system in diabetic retinopathy -- Genetic manipulation and genetic variation of the Kallikrein Kinin System; impact on cardiovascular and renal diseases.
    Digital Access  Springer 2014
  • Digital
    Ahmed M. Abdel-Azeem, editor.
    Chaetomium genus was established by Gustav Kunze in 1817. According to Index Fungorum Partnership, there are 273 Chaetomium species accepted till now. Members of the genus Chaetomium are capable of colonizing various substrates and are well-known for their ability to degrade cellulose and to produce a variety of bioactive metabolites. More than 200 compounds have been reported from this genus. A huge number of new and bioactive secondary metabolites associated with unique and diverse structural types, such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, depsidones, xanthones, anthraquinones, chromones, and steroids, have been isolated and identified. Many of the compounds have been reported to possess significant biological activities, such as antitumor, antimalarial, cytotoxic, enzyme inhibitory, antimicrobial, phytotoxic, antirheumatoid and other activities. Chaetomium taxa are frequently reported to be cellulase and ligninase producers with the ability to degrade cellulosic and woody materials. This is the first, comprehensive volume covering Chaetomium genus in detail. It includes the latest research, methods, and applications, and was written by scholars working directly in the field. The book also contains informative illustrations and is fully referenced for further reading.
    Digital Access  Springer 2020
  • Digital
    Yoko Kato, Xiaohua Zhang, Jiong Dai, Ahmed Ansari, editors.
    This book has included 19 recent topics about the treatment of cerebrovascular diseases from basics to surgical (include microneurosurgical, endovascular, endoscopic and Stereotactic radiosurgical techniques) aspects in the management of cerebrovascular diseases. With illustrative cases, the treatment strategies, techniques and complication avoidance have been covered extensively in the chapters to guide the readers on when and what to expect the worst in surgeries. The neurosurgical aspect in the present scenario of COVID is also included. This book will assist the junior neurosurgeons and junior neurological physicians in endeavoring to learn the core concepts and common problems of cerebrovascular surgery. This is a worthwhile addition in this ever growing field of cerebrovascular surgery.
    Digital Access  Springer 2021
  • Digital
    editors, John Colombo, Berthold Koletzko, Michelle Lampl.
    Implications of growth as a time-specific event / M. Lampl -- Elongation of the long bones in humans by the growth plates / E.B. Hunziker -- Critical windows for the programming effects of early-life nutrition on skeletal muscle mass / M.L. Fiorotto, T.A. Davis -- Fat tissue growth and development in humans / P. Arner -- Osteoblast bioenergetics and global energy homeostasis / A.R. Verardo, T.L. Clemens -- Summary on a systems perspective on growth / M. Lampl -- Breastfeeding, breast milk composition, and growth outcomes / M.V. Lind, A. Larnkjar, C. Molgaard, K.F. Michaelsen -- Metabolic regulation of pre- and postnatal growth / B. Koletzko, F.F. Kirchberg, C. Hellmuth, M. Weber, V. Grote, H. Demmelmair, M. Standl, J. Heinrich, E. Thiering, O. Uhl -- Complementary feeding, infant growth, and obesity risk : timing, composition, and mode of feeding / V. Grote, M. Theurich, V. Luque, D. Gruszfeld, E. Verducci, A. Xhonneux, B. Koletzko -- Causes of stunting and preventive dietary interventions in pregnancy and early childhood / R.E. Black, R. Heidkamp -- Micronutrients and child growth : current evidence and progress / R. Sharma, T. Vaivada, Z.A. Bhutta -- Summary on dietary modulation of growth and body composition / B. Koletzko -- A nutritionist's perspective on behavioral assessment / S.E Carlson -- Assessing neurocognitive development in studies of nutrition / J. Colombo -- Neuroimaging of the developing brain and impact of nutrition / S.C.L. Deoni -- Effects of nutrition on the development of higher-order cognition / P. Willatts -- Impact of nutrition on growth, brain, and cognition / M.M. Black -- Summary on nutrition, brain function, and cognitive development / J. Colombo.
    Digital Access  Karger 2018
  • Digital
    Sudesh Kumar Yadav, Vinay Kumar, Sudhir P. Singh, editors.
    Remarkable research has yielded whole genome data in plants, resulting in the documentation of an ever-increasing number of genes, without establishing their functions. The huge data resources available at the genome, transcriptome, proteome and metabolome levels are of enormous value in the field of functional genomics. This book provides insights into interpreting the sea of data in order to understand basic and practical aspects of plant metabolic engineering. It discusses in detail ways to tap into this enormous pool of data to increase productivity, and offers information that is both interesting and necessary for exploring the manipulation of metabolic pathways. The interdisciplinary approaches presented here also serve as a source of ideas for practical applications.
    Digital Access  Springer 2018
  • Digital
    Sundas Fayyaz, Ammad Ahmad Farooqi, editors.
    Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R & D departments.
    Digital Access  Springer 2018
  • Digital
    Karuna Singh, Neelabh Srivastava, editors.
    Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the readers convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.
    Digital Access  Springer 2019
  • Digital
    Ajar Nath Yadav, editor.
    Springer Nature eBook.
    Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients - a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and enhance soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play a significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrade waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of Recent Trends in Mycological Research aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.
    Digital Access  Springer 2021
  • Digital
    Ajar Nath Yadav, editor.
    Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients--a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrading waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of "Recent Trends in Mycological Research" aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.
    Digital Access  Springer 2021
  • Digital
    edited by Anthony P. Davenport.
    Receptor databases and computational websites for ligand binding / Brinda K. Rana, Philip E. Bourne, and Paul A. Insel -- How to use the IUPHAR receptor database to navigate pharmacological data / Chidochangu P. Mpamhanga [and others] -- Radioligand binding assays and their analysis / Janet J. Maguire, Rhoda E. Kuc, and Anthony P. Davenport -- Use of scintillation proximity assay to measure radioligand binding to immobilized receptors without separation of bound from free ligand / Jenny Berry, Molly Price-Jones, and Barbara Killian -- Visualization and analysis of vascular receptors using confocal laser scanning microscopy and fluorescent ligands / Craig J. Daly, Ingela Parmryd, and John C. McGrath -- Dissecting the pharmacology of G protein-coupled receptor signaling complexes using bimolecular fluorescence complementation / Laura E. Kilpatrick and Nicholas D. Holliday -- Live cell imaging of G protein-coupled receptors / Anke Teichmann [and others] -- Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays / Daniel L. Bassoni [and others] -- Measurements of [beta]-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation / Daniel L. Bassoni [and others] -- Quantitative phosphor imaging autoradiography of radioligands for positron emission tomography / Peter Johnstrom, Joseph L. Bird, and Anthony P. Davenport -- Dynamic in vivo imaging of receptors in small animals using positron emission tomography / Peter Johnstrom [and others] -- Cellular localization of receptors using antibodies visualized by light and dual labeling confocal microscopy / Anthony P. Davenport and Rhoda E. Kuc -- Detection of mRNA encoding receptors by in situ and northern hybridization / Alessandra P. Princivalle [and others].
    Digital Access  Springer 2012
  • Digital
    edited by P. Michael Conn.
    This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come.
    Digital Access  ScienceDirect 2013
  • Digital
    edited by Gary B. Willars and R.A. John Challiss.
    Inducible expression of G protein-coupled receptors in transfected cells / Beryl Koener and Emmanuel Hermans -- Using the Flp-In T-Rex system to regulate GPCR expression / Richard J. Ward, Elisa Alvarez-Curto, and Graeme Milligan -- Viral infection for GPCR expression in eukaryotic cells / Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi -- Generation of epitope-tagged GPCRs / Yan Huang and Gary B. Willars -- Use of site-directed mutagenesis to study GPCRs / Alex C. Conner [and others] -- Approaches to study GPCR regulation in native systems / Jonathon M. Willets -- Heterologous expression of GPCRs in fission yeast / John Davey and Graham Ladds -- Radioligand binding methods for membrane preparations and intact cells / David B. Bylund and Myron L. Toews -- Quantification of GPCR mRNA using real-time RT-PCR / Trond Brattelid and Finn Olav Levy -- Determining allosteric modulator mechanism of action : integration of radioligand binding and functional assay data / Christopher J. Langmead -- Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells / Stephen J. Briddon, Barrie Kellam, and Stephen J. Hill -- Examining site-specific GPCR phosphorylation / Adrian J. Butcher, Andrew B. Tobin, and Kok Choi Kong -- Ubiquitination of GPCRs / Adriana Caballero and Adriano Marchese -- [35S]GTPgS binding as an index of total G-protein and Ga-subtype-specific activation by GPCRs / Rajendra Mistry, Mark R. Dowling, and R.A. John Challiss -- Using calcium imaging as a readout of GPCR activation / Martin D. Bootman and H. Llewelyn Roderick -- Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors / Frank Gesellchen [and others] -- Determining the activation of Rho as an index of receptor coupling to G12/13 proteins / Michio Nakaya [and others] -- Use of translocating fluorescent biosensors for real-time monitoring of GPCR-mediated signaling events / Carl P. Nelson and R.A. John Challiss -- Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs / Ashley E. Brady [and others] -- Study of GPCR-protein interactions by BRET / Martina Kocan and Kevin D.G. Pfleger -- Time resolved FRET strategy with fluorescent ligands to analyze receptor interactions in native tissues : application to GPCR oligomerization / Martin Cottet [and others] -- Peptide affinity purification for the isolation and identification of GPCR-associated protein complexes / Pascal Maurice, Avais M. Daulat, and Ralf Jockers -- Tandem affinity purification and identification of GPCR-associated protein complexes / Avais M. Daulat, Pascal Maurice, and Ralf Jockers -- Identification of GPCR localization in detergent resistant membranes / Ranju Kumari and Anna Francesconi -- Analysis of GPCR localization and trafficking / James N. Hislop and Mark von Zastrow -- Statistical methods in research / Domenico Spina.
    Digital Access  Springer 2011
  • Digital
    edited by Rakesh Kumar, Paul B. Fisher.
    Digital Access  ScienceDirect 2020
  • Digital
    edited by Serena Germano.
    Analysis of receptor tyrosine kinase (RTK) phosphorylation by immunoblotting / Martina McDermott and Norma O'Donovan -- Analysis of changes in phosphorylation of receptor tyrosine kinases : antibody arrays / Sweta Rani and Lorraine O'Driscoll -- Analysis of epidermal growth factor receptor dimerization by BS³ cross-linking / Harmony F. Turk and Robert S. Chapkin -- Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells / Inhee Chung and Ira Mellman -- Evaluation of the dimerization profiles of HER tyrosine kinases by time-resolved Förster resonance energy transfer (TR-FRET) / Evelyne Lopez-Crapez [and three others] -- Applying the proximity ligation assay (PLA) to mouse preimplantation embryos for identifying protein-protein interactions in situ / Ivan Bedzhov and Marc P. Stemmler -- Analysis of receptor tyrosine kinase gene amplification on the example of FGFR1 / Diana Boehm, Anne von Mässenhausen, and Sven Perner -- Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells / Lijuan He and Kalina Hristova -- Cell surface biotinylation of receptor tyrosine kinases to investigate intracellular trafficking / Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan -- Studying N-linked glycosylation of receptor tyrosine kinases / Harri M. Itkonen and Ian G. Mills -- Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen / Hojin Lee and Anton M. Bennett -- Downregulation of receptor tyrosine kinases through ubiquitination : analysis by immunodetection / Noriaki Shimokawa and Noriyuki Koibuchi -- Regulation of receptor tyrosine kinases by miRNA : overexpression of miRNA using lentiviral inducible expression vectors / XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai -- Human tumor xenografts in mouse as a model for evaluating therapeutic efficacy of monoclonal antibodies or antibody-drug conjugate targeting receptor tyrosine kinases / Liang Feng [and five others] -- Receptor tyrosine kinase targeting in multicellular spheroids / Susan Breslin and Lorraine O'Driscoll -- Receptor tyrosine kinases and drug resistance : development and characterization of in vitro models of resistance to RTK inhibitors / Claire Corcoran and Lorraine O'Driscoll.
    Digital Access  Springer 2015
  • Print
    edited by R. D. O'Brien.
    v. 1. General principles and procedures.
    Print Status unknown
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)1979-QH603.C43R43
  • Print
    edited by Jorge R. Pasqualini.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)1976-QP572.S7 R42
  • Digital/Print
    par Edouard Dulaurier.
    t. 1. Chronologie technique.
    Digital Access  Google Books 1859-
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.v. 1, 1859.D303.5 .D9 18591
  • Digital
    Raffi Gurunian, Risal Djohan, editors.
    This book offers a comprehensive review of reconstructive microsurgery with an emphasis on the recipient vasculature. Chapters describe the anatomy, exposure, and technical considerations of recipient vessels in reconstructive microsurgery. The book strives to fill that void of literature covering recipient vessels and their surgical exposure for microvascular anastomosis. Alongside nuanced description for each particular body structure, the chapters will provide illustrations and short video clips on how to prepare these essential vessels. The book is the accumulation of the editors many years of experience in Asia, Europe, and the United States and also features contributions from world experts. Recipient Vessels in Reconstructive Microsurgery -- Anatomy and Technical Considerations is a must-have resource for trainees and residents as well as surgeons working in plastic surgery and microsurgery.
    Digital Access  Springer 2021
  • Digital
    John F. Atkins, Raymond F. Gesteland, editors.
    Part I. Redefinition -- 1. Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes / Vadim N. Gladyshev and Dolph L. Hatfield -- 2. Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors / Marla J. Berry and Michael T. Howard -- 3. Translation of UAG as Pyrrolysine / Joseph A. Krzycki -- 4. Specification of Standard Amino Acids by Stop Codons / Olivier Namy and Jean-Pierre Rousset -- 5. Ribosome “Skipping”: “Stop-Carry On” or “StopGo” Translation / Jeremy D. Brown and Martin D. Ryan -- 6. Recoding Therapies for Genetic Diseases / Kim M. Keeling and David M. Bedwell -- Part II. Frameshifting - Redirection of Linear Readout -- 7. Pseudoknot-Dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models / Ian Brierley, Robert J.C. Gilbert, and Simon Pennell -- 8. Programmed -1 Ribosomal Frameshift in the Human Immunodeficiency Virus of Type 1 / Léa Brakier-Gingras and Dominic Dulude -- 9. Ribosomal Frameshifting in Decoding Plant Viral RNAs / W. Allen Miller and David P. Giedroc -- 10. Programmed Frameshifting in Budding Yeast / Philip J. Farabaugh -- 11. Recoding in Bacteriophages / Roger W. Hendrix -- 12. Programmed Ribosomal -1 Frameshifting as a Tradition: The Bacterial Transposable Elements of the IS3 Family / Olivier Fayet and Marie-Françoise Prère -- 13. Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals / Ivaylo P. Ivanov and Senya Matsufuji -- 14. Sequences Promoting Recoding Are Singular Genomic Elements / Pavel V. Baranov and Olga Gurvich -- 15. Mutants That Affect Recoding / Jonathan D. Dinman and Michael O'Connor -- 16. The E Site and Its Importance for Improving Accuracy and Preventing Frameshifts / Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, and Knud H. Nierhaus -- Part III. Discontiguity -- 17. Translational Bypassing - Peptidyl-tRNA Re-pairing at Non-overlapping Sites / Norma M. Wills -- 18. trans-Translation / Kenneth C. Keiler and Dennis M. Lee -- Part IV. Transcription Slippage -- 19. Transcript Slippage and Recoding / Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, and William T. McAllister -- Part V. Appendix -- 20. Computational Resources for Studying Recoding / Andrew E. Firth, Michaël Bekaert, and Pavel V. Baranov.
    Digital Access  Springer 2010
  • Digital/Print
    edited by Yuan C. Lee, Reiko T. Lee.
    Digital Access  
    ProviderVersion
    ScienceDirectpt. A
    ScienceDirectpt. B
  • Digital
    Christina Meyer.
    The adaptive immune system is composed of [alpha beta] T cells, [gamma delta] T cells, and B cells, all of which express diverse rearranged antigen receptors and have been conserved together through evolution. [gamma delta] T cells make up the minority of circulating T cells and perform many of the same effector functions as [alpha beta] T cells, including cytotoxic functions and the production of cytokines like IL-17, IFN-[gamma], and IL-4. However, the conservation of [gamma delta] T cells suggests that they fill a non-redundant role in the adaptive immune system. Because their functions overlap, it is likely that [gamma delta] T cells are distinctive from [alpha beta] T cells in the way they are triggered by antigen. These antigenic triggers of [gamma delta] T cells remain poorly defined, but a more thorough knowledge of this repertoire will enhance understanding of the role of [gamma delta] T cells in the immune response. The identification of new [gamma delta] T cell antigens was undertaken, resulting in the discovery of hapten small molecule [gamma delta] T cell ligands and the identification of a diverse group of additional candidate [gamma delta] T cell ligands. With the discovery that [gamma delta] T cell receptors can recognize small molecules in addition to their known large protein ligands, it is clear that [gamma delta] T cells fill a unique role in the adaptive immune system is solidified with a broad capacity for antigen recognition along with all the functionality of T cells, and are uniquely situated to function together with [alpha beta] T cells and B cells in a concerted antigen-specific response.
    Digital Access   2012
  • Digital
    by Leon Chaitow, Christopher Gilbert, Dinah Bradley.
    This book is intended to help practitioners understand the causes and effects of disordered breathing and to provide strategies and protocols to help restore normal function. Fully updated throughout, this volume has been completely revised to guide the practitioner in the recognition of breathing pattern disorders and presents the latest research findings relating to the condition including a range of completely new techniques - many from an international perspective - to help restore and maintain normal functionality. Video clips on an associated website presents practical examples of the breathing techniques discussed in the book. Carefully prepared by a global team of renowned experts under the guidance of Leon Chaitow Focuses on practical, validated, and clinically relevant information Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Contains clinical cases to ensure full comprehension of the topics explored Suitable for physiotherapists, manual therapists, physical therapists, osteopaths, osteopathic physicians and chiropractors, massage therapists, Pilates and yoga teachers & therapists, Tai chi and Feldenkrais practitioners, athletic coaches and voice-coaches.
    Digital Access  
    ProviderVersion
    ScienceDirect2014
    ClinicalKey Nursing2014
  • Digital
    Alan E. Oestreich, Marguerite M. Caré.
    Introduction -- Plain images -- Ultrasound, CT, MR, Nuclear Imaging, PET -- Rule out alternate diagnosis -- Neuroradiology -- Abdominal Thoracic, and subcutaneous abnormalities -- Beyond the images -- Contra the zealous abuse deniers -- Documenting concern for abuse -- Importance and role of non-radiologist child abuse team -- Conclusion.
    Digital Access  Springer 2017
  • Digital
    edited by Graeme L. Conn.
    Purification of RNA expressed in vivo inserted in a tRNA scaffold / Luc Ponchon and Frederic Dardel -- Selective RNase H cleavage of target RNAs from a tRNA scaffold / Luc Ponchon [and others] -- Preparation of long templates for RNA in vitro transcription by recursive PCR / Jessica C. Bowman [and others] -- General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE / Jo L. Linpinsel and Graeme L. Conn -- Preparation of short RNA by in vitro transcription / Cheng Lu and Pingwei Li -- Native RNA purification by gel filtration chromatography / Evan P. Booy, Hui Meng, and Sean A. McKenna -- Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5ʹ and 3ʹ ends / Johanna M. Avis, Graeme L. Conn, and Scott C. Walker -- Trans-acting antigenomic HDV ribozyme for production of in vitro transcripts with homogenous 3ʹ ends / Milena Szafraniec [and others] -- Rapid preparation of RNA samples using DNA-affinity chromatography and DNAzyme methods / Hae-Kap Cheong, Eunha Hwang, and Chaejoon Cheong -- Preparation of lN-GST fusion protein for affinity immobilization of RNA / Genevieve Di Tomasso [and others] -- Affinity purification of RNA using an ARiBo tag / Genevieve Di Tomasso [and others] -- Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments / Virginia K. Vachon and Graeme L. Conn -- In vitro transcription of modified RNAs / Stephanie L. Moon and Jeffrey Wilusz -- End-labeling oligonucleotides with chemical tags after synthesis / N. Ruth Zearfoss and Sean P. Ryder -- High-purity enzymatic synthesis of site-specifically modified tRNA / Ya-Ming Hou -- Se-derivatized RNAs for x-ray crystallography / Lina Lin and Zhen Huang -- Biosynthetic preparation of 13C/15N-labeled rNTPs for high-resolution NMR studies of RNAs / Luigi Martino and Maria R. Conte -- Preparative separation of ribonucleoside monophosphates by ion-pair reverse-phase HPLC / Pierre Dagenais and Pascale Legault -- Splint ligation of RNA with T4 DNA ligase / Christopher J. Kershaw and Raymond T. O'Keefe.
    Digital Access  Springer 2012
  • Digital
    Theam Soon Lim, editor.
    1. Filamentous phage: structure and biology -- 2. Antibody phage display -- 3. Naive human antibody libraries for infectious diseases -- 4. Immune human antibody libraries for infectious diseases -- 5. Synthetic antibodies in infectious disease -- 6. Monoclonal antibodies and antibody like fragments derived from immunised phage display libraries -- 7. Anti-bacterial monoclonal antibodies -- 8. Anti-parasitic antibodies from phage display -- 9. Therapeutic antibodies for biodefense -- 10. Engineering antibodies for the treatment of infectious diseases -- 11. Computer-aided antibody design: an overview -- 12. Using high-throughput sequencing to characterize the development of the antibody repertoire during infections: a case study of HIV-1 -- 13. Safety and general considerations for the use of antibodies in infectious diseases -- Index.
    Digital Access  Springer 2017
  • Digital/Print
    edited by Ray Wu.
    Digital Access  ScienceDirect 1992
  • Digital/Print
    edited by Ray Wu.
    Digital Access  ScienceDirect 1993
  • Digital/Print
    edited by Ray Wu.
    Digital Access  ScienceDirect 1993
  • Digital
    edited by Argelia Lorence.
    Using folding promoting agents in recombinant protein production : a review / Beatrix Fahnert -- Routine identity confirmation of recombinant proteins by MALDI-TOF mass spectrometry / Brett J. Savary and Prasanna Vasu -- A matter of packaging : influence of nucleosome positioning on heterologous gene expression / María de la Cruz Muñoz-Centeno, Gonzalo Millán-Zambrano, and Sebastián Chávez -- Tools of the trade : developing antibody-based detection capabilities for recombinant proteins / Maureen C. Dolan [and others] -- Heat-shock protein fusion vectors for improved expression of soluble recombinant proteins in Escherichia coli / Christos A. Kyratsous and Christos A. Panagiotidis -- The use of a flagellar export signal for the secretion of recombinant proteins in salmonella / Ferenc Vonderviszt [and others] -- Optimization of purification protocols based on the step-by-step monitoring of the protein aggregates in soluble fractions / Ario de Marco -- Heterologous protein expression by Lactococcus lactis / Julio Villator-Hernández [and others] -- An extended suite of genetic tools for use in bacteria of the halomonadaceae : an overview / Montserrat Argandoña [and others] -- Regulated recombinant protein production in the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Valentina Rippa [and others] -- A novel strategy for the construction of genomic mutants of the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Maria Giuliani [and others] -- A new bacterial co-expression system for over-expressing soluble protein and validating protein-protein interaction / Jumei Zeng and Zheng-Guo He -- Heterologous high-level gene expression in the photosynthetic bacterium Rhodobacter capsulatus / Nadine Katzke [and others] -- Plasmid DNA production for therapeutic applications / Alvaro R. Lara and Octavio T. Ramírez -- Recombinant protein production in the eukaryotic protozoan parasite Leishmania tarentolae : a review / Tomoaki Niimi -- Expression of multisubunit proteins in Leishmania tarentolae / Marisa Sugino and Tomoaki Niimi -- Recombinant protein production in yeasts / Diethard Mattanovich [and others] -- Yeasts as a tool for heterologous gene expression / Raja Mokdad-Gargouri [and others] -- The Cre/Lox system : a practical tool to efficiently eliminate selectable markers in fungal endophytes / Simona Florea [and others] -- Aptamer-regulated expression of essential genes in yeast / Beatrix Suess [and others] -- Cloning and expression of hemicellulases from Aspergillus nidulans in Pichia pastoris / Prasanna Vasu, Stefan Bauer, and Brett J. Savary -- A thiamine-regulatable epitope-tagged protein expression system in fission yeast / Tiina Tamm -- Heterologous gene expression by chromosomal integration in fission yeast / Akihisa Matsuyama and Minoru Yoshida -- Genetic engineering of industrial strains of Saccharomyces cerevisiae / Sylvie le Borgne -- Recombinant protein production in plants : challenges and solutions / Elizabeth E. Hood and Deborah V. Vicuna Requesens -- A novel plant cell bioproduction platform for high-yield secretion of recombinant proteins / Jianfeng Xu and Marcia J. Kieliszewski -- Super-promoter :TEV, a powerful gene expression system for tobacco hairy roots / Luis Ñopo [and others] -- Bioseparation of recombinant proteins from plant extract with hydrophobin fusion technology / Jussi J. Joensuu [and others] -- Quality assessment of recombinant proteins produced in plants / Giuliana Medrano [and others] -- Cell-free protein synthesis as a promising expression system for recombinant proteins / Xumeng Ge and Jianfeng Xu -- The use of bacterial artificial chromosomes for recombinant protein production in mammalian cell lines / Leander Blaas [and others] -- Engineering the chaperone network of CHO cells for optimal recombinant protein production and authenticity / Lyne Jossé, C. Mark Smales, and Mick F. Tuite -- High-throughput baculovirus expression in insect cells / Richard B. Hitchman, Robert D. Possee, and Linda A. King -- Recombinant protein expression in milk of livestock species / Zsuzsanna Bösze and László Hiripi.
    Digital Access  Springer 2012
  • Digital
    edited by Virgínia Picanço-Castro, Kamilla Swiech.
    Digital Access  Springer 2018
  • Digital
    edited by William B. O'Dell, Zvi Kelman.
    Digital Access  ScienceDirect 2021
  • Digital
    edited by Zvi Kelman, William B. O'Dell.
    Digital Access  ScienceDirect 2021
  • Digital
    edited by David L. Hacker.
    Transient gene expression in suspension HEK293-EBNA1 cells / Denis L'Abbe, Louis Bisson, Christian Gervais, Eric Grazzini, and Yves Durocher -- Transient expression of recombinant membrane-eGFP fusion proteins in HEK293 cells / Joanna Pieprzyk, Samuel Pazicky, and Christian Low -- PEI-mediated transient gene expression in CHO cells / Yashas Rajendra -- Stable expression by lentiviral transduction of cells / Natascha Godecke, Hansjorg Hauser, and Dagmar Wirth -- Inducible protein production in 293 cells using the piggyBac Transposon System / Iacovos P. Michael and Andras Nagy -- Recombinant CHO cell pool generation using piggyBac transposon system / Sowmya Balasubramanian -- Genome engineering of hybridomas to generate stable cell lines for antibody expression / Cristina Parola, Derek M. Mason, Andreas Zingg, Daniel Neumeier, and Sai T. Reddy -- Protein expression via transient transfection of mammalian cells in a WAVE bioreactor / David I. Fisher -- CHO and HEK293 cultivation and transfection in single-use orbitally shaken bioreactors / David L. Hacker, Laurence Durrer, and Soraya Quinche -- Bench-scale stirred-tank bioreactor for recombinant protein production in Chinese hamster ovary (CHO) cells in suspension / Dominique T. Monteil and Jeffrey Kuan -- Continuous and integrated expression and purification of recombinant antibodies / Sebastian Vogg, Moritz Kai Florian Wolf, and Massimo Morbidelli -- High throughput transfection of HEK293 cells for transient protein production / Tia A. Arena, Peter D. Harms, and Athena W. Wong -- Microfluidic transfection for high-throughput mammalian protein expression / Kristina Woodruff and Sebastian J. Maerkl -- Genome-wide high-throughput RNAi screening for identification of genes involved in protein production / Sarah Inwood, Michael J. Betenbaugh, Madhu Lal, and Joseph Shiloach -- Targeting miRNAs with CRISPR/Cas9 to improve recombinant protein production of CHO cells / Kevin Kellner, Ankur Solanki, Thomas Amann, Nga Lao, and Niall Barron -- Application of the CRISPR/Cas9 gene editing method for modulating antibody fucosylation in CHO cells / Qiong Wang, Cheng-Yu Chung, Julian N. Rosenberg, Geng Yu, and Michael J. Betenbaugh -- Scalable production and purification of adeno-associated viral vectors (AAV) / Daniel Blessing, Nicole Deglon, and Bernard L. Schneider -- Considerations in the use of codon optimization for recombinant protein expression / Vincent P. Mauro and Stephen A. Chappell -- Versatile cell-free protein synthesis systems based on Chinese hamster ovary cells / Lena Thoring and Stefan Kubick.
    Digital Access  Springer 2018
  • Digital
    edited by Roslyn M. Bill.
    Optimising yeast as a host for recombinant protein production (review) / Nicklas Bonander and Roslyn M. Bill -- Which yeast species shall I choose? : Saccharomyces cerevisiae versus Pichia pastoris (review) / Richard A.J. Darby [and others] -- Preparation of Pichia pastoris expression plasmids / Christel Logez [and others] -- Preparation of Saccharomyces cerevisiae expression plasmids / David Drew and Hyun Kim -- Codon optimisation for heterologous gene expression in yeast / Kristina Hedfalk -- Yeast transformation to generate high-yielding clones / Mohammed Jamshad and Richard A.J. Darby -- Screening for high-yielding Pichia pastoris clones : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Screening for high-yielding Saccharomyces cerevisiae clones: using a green fluorescent protein fusion strategy in the production of membrane proteins / David Drew and Hyun Kim -- The effect of antifoam addition on protein production yields / Sarah J. Routledge and Roslyn M. Bill -- Setting up a bioreactor for recombinant protein production in yeast / Sarah J. Routlledge and Michelle Clare -- The implementation of a design of experiments strategy to increase recombinant protein yields in yeast (review) / Nagamani Bora [and others] -- Online analysis and process control in recombinant protein production (review) / Shane M. Palmer and Edmund R.S. Kunji -- Monitoring the biomass accumulation of recombinant yeast cultures : offline estimations of dry cell mass and cell counts / Shane M. Palmer and Edmund R.S. Kunji -- Online monitoring of biomass accumulation in recombinant yeast cultures / Shane M. Palmer and Edmund R.S. Kunji -- Optimising Pichia pastoris induction / Zharain Bawa and Richard A.J. Darby -- Optimizing Saccharomyces cerevisiae induction regimes / David Drew and Hyun Kim -- Large-scale production of membrane proteins in Pichia pastoris : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Large-scale production of secreted proteins in Pichia pastoris / Nagamani Bora -- Disruption of yeast cells to isolate recombinant proteins / Mohammed Jamshad and Richard A.J. Darby.
    Digital Access  Springer 2012
  • Digital
    edited by Loïc Faye and Véronique Gomord.
    From Neanderthal to nanobiotech : from plant potions to pharming with plant factories / Christophe Sourrouille ... [et al.] -- Cowpea mosaic virus-based systems for the expression of antigens and antibodies in plants / Frank Sainsbury, Li Liu, and George P. Lomonossoff -- Transient expression of antibodies in plants using syringe agroinfiltration / Marc-André D'Aoust ... [et al.] -- Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants / Giuliana Medrano ... [et al.] -- Production and localization of recombinant pharmaceuticals in transgenic seeds / Thomas Rademacher, Elsa Arcalis, and Eva Stoger -- Production of antibody fragments in Arabidopsis seeds / Bart Van Droogenbroeck, Kirsten De Wilde, and Ann Depicker -- Production of plantibodies in Nicotiana plants / Marta Ayala ... [et al.] -- Physcomitrella patens : a non-vascular plant for recombinant protein production / David Liénard and Fabien Nogué -- Production of recombinant proteins in suspension-cultured plant cells / Carole Plasson ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals : protocols for expression, purification, or oral delivery and functional evaluation / N. Dolendro Singh, Yi Ding, and Henry Daniell -- Protein body induction : a new tool to produce and recover recombinant proteins in plants / Margarita Torrent, Imma Llop-Tous, and M. Dolors Ludevid -- A case study for plant-made pharmaceuticals comparing different plant expression and production systems / Guy Vancanneyt ... [et al.] -- Glycosylation of antibody therapeutics : optimisation for purpose / Roy Jefferis -- N-glycosylation of plant recombinant pharmaceuticals / Muriel Bardor ... [et al.] -- Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts / Meriem Benchabane ... [et al.] -- Strategies for improving vaccine antigens expression in transgenic plants : fusion to carrier sequences / Jose M. Escribano and Daniel M. Perez-Filgueira -- Immunomodulation of plant function by in vitro selected single-chain Fv intrabodies / Manfred Gahrtz and Udo Conrad -- On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI-TOF MS / Amine M. Badri ... [et al.] -- Assessing the risk of undesirable immunogenicity/allergenicity of plant-derived therapeutic proteins / Paul D. Chamberlain -- Biosafety, risk assessment, and regulation of plant-made pharmaceuticals / Penelope A.C. Sparrow and Richard M. Twyman.
    Digital Access  Springer 2009
  • Digital
    edited by Maureen C. Ferran and Gary R. Skuse.
    Digital Access  Springer 2017
  • Digital
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    "Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Anibidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume."--Jacket.
    Digital Access  Springer 2008
  • Digital
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm - in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillar.
    Digital Access  Springer 2008
  • Digital
    edited by Ron Vale ; contributors Anna Akhmanova [and seven nine others].
    Actin filament dynamics using microfluidics -- Bacterial actin-like proteins: purification and characterization of self-assembly properties -- Quantitative analysis of microtubule self-assembly kinetics and tip structure -- Biochemical reconstitution of the WAVE regulatory complex -- Rotational movement of formins evaluated by using single-molecule fluorescence polarization -- Single-molecule studies of actin assembly and disassembly factors -- Assaying microtubule nucleation of the [gamma]-Tubulin ring complex -- Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins -- Generation of differentially modified microtubules using In Vitro enzymatic approaches -- Engineering defined motor ensembles with DNA origami -- Construction and analyses of elastically coupled multiple-motor systems -- Reconstitution of cortical dynein function -- Reconstitution of microtubule-dependent organnelle transport -- Reconstituting the motility of isolated intracellular cargoes -- Reconstitution of contractile actomyosin arrays -- Directed actin assembly and motility -- In Vitro reconstitution of dynamic microtubules interacting with actin filament networks -- Measuring kinetochore-microtubule interaction In Vitro -- Micropattern-guided assembly of overlapping pairs of dynamic microtubules -- WAVE regulatory complex activation -- Dissecting principles governing actin assembly using yeast extracts -- Xenopus egg ctyoplasm with intact actin -- Glycogen-supplemented mitotic cytosol for analyzing xenopus egg microtubule organization -- Spindle assembly on immmobilized chromatin micropatterns.
    Digital Access  ScienceDirect 2014
  • Digital/Print
    edited by James E. Rothman.
    Digital Access  ScienceDirect 1992
  • Digital
    Ghassan Soleiman Abu-Sittah, Jamal J. Hoballah, Joseph Bakhach, editors.
    Digital Access  Springer 2017
  • Digital
    Eric M. Genden ; illustrations by Scott M. Kessler.
    Written and edited by renowned leaders in the field, this text takes a defect-oriented approach that enables surgeons to match their patients defects with those included in the book and offers clinicians guidance on the latest techniques for achieving optimal functional and aesthetic surgical results. Topics covered include oromandibular complex reconstruction, skull base reconstruction, microvascular reconstruction, and more. Special Features: Authors have organized the chapters by specific defect, so readers can easily find the reconstructive options for their patients. Experts cover the reconstruction of major soft tissue, bony and muscular defects of the head, neck, and skull base in detail. More than 200 color illustrations help clarify the surgical methods described in the text. Experienced surgeons review approaches to reconstruction and the fine points that surgeons need to know for the best outcomes. For each defect, the steps in the procedure, the orientations of the flap, and the details that confer excellent surgical results are covered. Surgeons and fellows involved in head and neck reconstruction will greatly benefit from the extensive coverage of the best methods to treat some of the most challenging defects they will face.
    Digital Access  
    ProviderVersion
    Thieme MedOne Plastic Surgery2012
    Thieme MedOne Otolaryngology2012
  • Digital
    Petr Suchomel, Ondřej Choutka ; with contributions by Jan Hradil ... [et al.].
    Surgical anatomy -- Biomechanical remarks -- Special radiology -- Surgical approaches -- Basic principles of reconstruction techniques -- Specific reconstruction techniques of upper cervical spine and craniovertebral junction -- Virtual and real time navigational techniques -- Traumatic atlantooccipital dislocation (AOD) -- Occipital condyle fractures -- Atlas fractures -- Odontoid process fractures -- Fractures of the ring of axis (hangman type fractures) -- Miscellaneous C2 fractures -- Multiple fractures of axis and atlas-axis fracture combinations -- Acute traumatic atlantoasial dislocation (AAD) in adults -- Posttraumatic deformity -- Non-specific inflammation -- Rheumatoid arthritis -- Tumors -- Congenital and developmental abnormalities -- Degenerative disorders -- Surgical failures.
    Digital Access  Springer 2011
  • Digital
    Joe R. McBride, Judith Stilgenbauer, Igor Lacan, Sheauchi Cheng, Scot Medbury, Deborah L. McBride.
    This book will address the destruction of urban forest in nine cities by bombing during World War II and the Bosnian War and their reconstruction in the post-war years. After reviewing the general objectives and results of aerial bombing, the book explores the effects of bombing and the reconstruction of urban forest in London, Coventry, Hamburg, Dresden, St. Petersburg, Stalingrad, Tokyo, Hiroshima, and Sarajevo. Sarajevo stands out among these cities because the destruction of its urban forest was the result of citizens cutting down trees for firewood during the siege of the city. Most of the cities studied developed plans for reconstruction either during or after the war. These plans often addressed the planning and re-establishment of the urban forest that had been destroyed. Urban planners often planned for infrastructure improvements such as new boulevards and parks where trees would be planted. After the war many of these plans were abandoned or significantly modified. Cost, resistance by property owners, control of reconstruction by authorities outside of the cities, and the lack of planting stock were factors contributing to the failure of many of the plans. Exceptions occurred in Hiroshima and Coventry where the destroyed cities became symbols of national reconstruction and every effort was made to redesign the destroyed portions of these cities as memorials to those who lost their lives and to demonstrate the rebirth of the cities. In several of the cities studied individual citizens undertook on their own the replanting of street and park trees. Their ingenuity, hard work, and dedication to trees in their cities was remarkable. A common factor limiting efforts to replant street and park trees was the lack of nursery stock. During and immediately after the wars nearly all nurseries that had supplied trees for city planting had been converted to vegetable gardens to produce food for the urban populations. The slow return to the production of trees for urban planting was a common factor in the time required in many cities to restore their street and park trees. There are lessons to be learned by urban planner, urban forester, and landscape architects from this book that will be useful in the future destruction of urban forest either by natural or man-made causes.
    Digital Access  Springer 2021
  • Digital
    [edited by] Philip H. Zeplin.
    Fundamentals and principles -- Techniques -- Genital surgery in children -- Functional and aesthetic genital surgery in the female -- Functional and aesthetic genital surgery in the male -- Transsexualism.
    Digital Access  
    ProviderVersion
    Thieme MedOne Plastic Surgery2019
    Thieme-Connect2019
  • Digital
    Hilko Weerda.
    Drawing on decades of operating room and teaching experience, Dr. Weerda and his team offer a complete guide to reconstructive options for facial, head, and neck defects in this eagerly awaited second edition. Their systematic, step-by-step approach, with an emphasis on meticulous preoperative planning, evaluation of alternatives, and selection of the best procedure, ensures optimal results for all patients. Focusing on the questions, problems, and technical solutions most commonly encountered in everyday practice, this compact book will be valuable to both the novice and more experienced su.
    Digital Access  
    ProviderVersion
    Thieme MedOne Plastic Surgery2014
    Thieme MedOne Otolaryngology2014
  • Digital
    Mark S. Myerson, Anish R. Kadakia.
    Chevron osteotomy -- The lapidus procedure -- Proximal phalangeal osteotomy (akin) -- Management of complications after correction of hallux valgus -- Hallux varus -- Hallux rigidus-joint-sparing techniques -- Correction of lesser toe deformity -- Correction of crossover toe deformity -- Management of metatarsalgia -- Surgery for the neuropathic foot and ankle -- Cavus foot correction -- Tendon transfers for management of paralytic deformity -- Correction of flatfoot deformity in the child -- Correction of flatfoot deformity in the adult -- Complications of treatment of flatfoot -- The use of bulk fresh osteoarticular allografts in ankle reconstruction -- Reconstruction of malunited ankle fractures -- Total ankle replacement -- Revision total ankle replacement -- Osteotomy of the tibia and fibula -- Disorders of the achilles tendon -- Rupture of the anterior tibial tendon -- Peroneal tendon injury and repair -- Tarsal coalition -- Tarsal coalition -- Ankle instability and impingement syndromes -- Management of osteochondral lesions of the talus -- Arthrodesis of the hallux metatarsophalangeal and interphalangeal joints -- Arthrodesis of the tarsometatarsal joint -- Subtalar arthrodesis -- Triple arthrodesis -- Ankle arthrodesis -- Tibiotalocalcaneal and pantalar arthrodesis.
    Digital Access  
    ProviderVersion
    ScienceDirect2019
    ClinicalKey2019
  • Digital
    [edited by] Darren L. Johnson.
    Digital Access  
    ProviderVersion
    Ovid2017
    LWW Health Library2017
  • Digital
    Ruediger G.H. Baumeister
    Pathophysiology of lymphedemas with respect to surgery -- Experimental basis of reconstructive lymphovascular surgery -- Reconstructive lymphovascular techniques -- Objectification of the Results -- Results of reconstructive lymphovascular surgery -- Reconstructive lymphovascular surgery and other lymphedema treating modalities.
    Digital Access  Springer 2017
  • Digital
    [edited by] Robert X Murphy, Charles K. Herman.
    "Reconstructive Plastic Surgery: An Atlas of Essential Procedures edited by esteemed authors, educators, and surgeons Robert X. Murphy Jr. and Charles K. Herman is a comprehensive resource detailing head-to-toe surgical procedures for a broad range of conditions. The senior editors have more than 50 years of collective surgical experience and expertise training hundreds of medical students and plastic surgery residents. A distinguished and diverse group of contributors from more than 15 countries and five continents share clinical pearls throughout the book. Sixty-seven chapters organized in five sections start with head and neck chapters detailing cleft palate defects and repair, followed by functional rhinoplasty, neoplasms, and trauma. Section two encompasses breast reduction/ reconstruction techniques and other breast deformities; and management of trunk ulcers, deep wounds, and defects. The hand and upper extremity section details reconstructive techniques for infections, trauma, and Dupuytren's contracture. The final two sections cover a wide spectrum of nerve-related conditions and syndromes, followed by burns, melanoma, and vascular anomalies"-- Provided by publisher.
    Digital Access  
    ProviderVersion
    Thieme MedOne Plastic Surgery2022
    Thieme-Connect2022
  • Digital
    Salah Rubayi ; with contributions by Burl R. Wagenheim and Alicia Mcleland.
    Digital Access  Springer 2015
  • Digital
    Matthew M. Hanasono, Geoffrey L. Robb, Roman J. Skoracki, Peirong Yu.
    Digital Access  
    ProviderVersion
    Thieme-Connect2016
    Thieme MedOne Plastic Surgery2016
    Thieme MedOne Otolaryngology2016
  • Digital
    Michael R. Zenn, Glyn Jones.
    Introduction: a systematic approach -- Vascular basis of flaps : flap classification -- Flap selection : analysis of features, modifications, and applications -- Clinical applications -- Head and neck -- Anterior thorax -- Posterior trunk -- Upper extremity -- Hand -- Abdomen -- Abdominal viscera -- Thigh -- Leg -- Foot.
  • Digital
    Günter Germann, L. Scott Levin, Randolph Sherman ; illustrator Amanda Tomasikiewicz.
  • Digital
    editors, Lee L.Q. Pu, Jamie P. Levine, Fu-Chan Wei.
  • Digital
    Andrew P. Zbar, Robert D. Madoff, Steven Wexner, editors.
    Reconstructive Surgery of the Rectum, Anus and Perineum provides the reader with a didactic discussion of complex problems which require re-operative surgery; including details of preoperative investigation, postoperative follow-up and a detailed operative approach. This comprehensive and detailed text uses a formulated algorithm approach to these complicated cases using operative photographs and composite explanatory line drawings which complement 'how-to' guides in describing the operative technical tips and pitfalls from experienced commentators. Reconstructive Surgery of the Rectum, Anus and Perineum, is written by leading world experts in the field of colorectal surgery and is a valuable and timely resource for colorectal surgeons and colorectal trainees alike. In addition, general surgeons will be interested in the specialist nature of dealing with difficult colorectal complications dealt with in this unique textbook.
    Digital Access  Springer 2013
  • Digital
    edited by Bradley J. Adams and John E. Byrd.
    Digital Access  Springer 2008
  • Digital
    edited by Brian G. Czito, Christopher G. Willett.
    Digital Access  Springer 2010
  • Digital
    Nicolò de Manzini, editor ; forewords by Gianluigi Melotti, Christiam Meyer.
    This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
    Digital Access  Springer 2013
  • Digital
    Donato F. Altomare, Filippo Pucciani (eds.).
    Digital Access  Springer 2008
  • Digital
    Deborah Wallace, Rodrick Wallace.
    As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its predecessor, the sequel examines the vulnerabilities that give rise to spikes in infection rates that form epicenters. Unlike the first wave, NYC was not the epicenter of the second wave; high-incident counties just outside NYS formed an extended initial epicenter and exported COVID-19 to neighboring counties of NYS. Rural NYS counties differed significantly from urban ones socioeconomically and in infection rates during the cresting period. Before the crest, no socioeconomic factor was associated with county infection rates; rather, the major associating factor was political and cultural: percent of the 2020 vote garnered by Trump. Rural counties voted heavily for Trump. This association disappeared post-crest by mid-January 2021. In NYC, the Bronx again behaved like a single high-incidence entity, unlike the other three boroughs that had patches of high and low infection incidence. Among the topics covered: The Second COVID Wave Washes Over New York State The Second Wave Storm-Surges Across New York City Discussion of County Data from the Second Wave of COVID-19 Parsing Meaning From the 152 ZIP Code Data The book closes with a prescription for pandemic response planning based on empowered communities and workers interacting with health departments as equals. The Recurrence of COVID-19 in New York State and New York City is a valuable resource for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also will find readership among students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
    Digital Access  Springer 2022
  • Digital
    Gregory W. Randolph, editor.
    Rates of RLN and SLN injury -- Data from National Quality Registries and the literature -- Laryngeal Exan Indications and Techniques -- Neurologic Control of the Larynx -- Micro-neuroanatomy of the Vagus, Superior Laryngeal, and Recurrent Laryngeal Nerves -- Intralaryngeal anatomy of the recurrent laryngeal nerve -- Imaging of the Recurrent Laryngeal Nerve -- RLN Nerve and Inferior Thyroid Crossing -- Recurrent Laryngeal Nerve Branching -- The Recurrent Laryngeal Nerve and the Tubercle of Zuckerkandl -- The Ligament of Berry -- The Non-recurrent inferior laryngeal nerve -- The Boston RLN anatomic classification system -- Surgical Approaches to the Recurrent Laryngeal Nerve -- IONM of the Recurrent Laryngeal Nerve -- Continuous Intraoperative Neuromonitoring (CIONM) of the Recurrent Laryngeal Nerve -- External Branch of Superior Laryngeal Nerve (EBSLN) Anatomic Classification -- Surgical approach and monitoring of the External Branch of the Super Laryngeal Nerve (EBSLN) -- Loss of signal in IONM and staged thyroid surgery -- Mechanism of Injury -- Intraoperative Neural Injury Management: Neuropraxic Non-Transection Injury -- Intraoperative Nerve Injury Management -- Transection and Segmental Defects -- Nerve Management: Invasive Disease -- Postoperative Management of Unilateral RLN Paralysis -- Postoperative management of bilateral vocal cord paralysis -- The recurrent laryngeal nerve and medical malpractice during thyroid surgery -- Postoperative Management of Superior Laryngeal Nerve Paralysis.
    Digital Access  Springer 2016
  • Digital
    Helena M. Tabery.
    This book on the morphology of corneal surface changes in recurrent erosion syndrome and epithelial edema presents high-magnification images captured in vivo by the method of non-contact photomicrography. Part I of the book, on recurrent erosion syndrome, displays images covering a broad spectrum of epithelial changes, including manifestations of the ongoing underlying pathological process and epithelial activity aimed at elimination of abnormal elements and repair. The dynamics of the interplay between these opposing forces are captured in sequential photographs that are invaluable for interpretation. Case reports illustrate typical features of the disease and document the variability of symptoms and findings in the same individual over time. Also included are images of the appearance and dynamics of corneal stromal infiltrates, a rare but potentially sight-threatening complication. Part II of the book demonstrates typical features of corneal epithelial edema and also covers the occasional contemporaneous occurrence, and dynamics, of various phenomena indistinguishable from those commonly seen in recurrent erosion syndrome. Again, informative case reports are included. The in vivo images displayed in this book, obtained at a higher magnification than that used in standard photography, reveal additional details of epithelial changes. The presented morphology will facilitate understanding of clinical appearances and assist in differential diagnosis.
    Digital Access  Springer 2015
  • Digital
    Jason M. Franasiak, Richard T. Scott Jr., editors.
    Digital Access  Springer 2018
  • Digital
    Sumita Mehta, Bindiya Gupta, editors.
    Digital Access  Springer 2018
  • Digital
    Asher Bashiri, Avi Harlev, Ashok Agarwal, editors.
    Part I: Introduction to Recurrent Pregnancy Loss -- Recurrent pregnancy loss: definitions, epidemiology, and prognosis -- Implantation, Physiology of Placentation -- Part II: Causes of Recurrent Pregnancy Loss -- Endocrine abnormalities in RPL -- Genetics of recurrent pregnancy loss -- Inherited and Acquired Thrombophilias and Adverse Pregnancy Outcomes -- Immunological causes of recurrent pregnancy loss -- Anatomical aspects in recurrent pregnancy loss -- Male Factors in Recurrent Pregnancy Loss -- Lifestyle and RPL -- The common characteristics between Infertility and recurrent pregnancy loss -- Part III: Management of Recurrent Pregnancy Loss. Contemporary Prevention and treatment of recurrent pregnancy loss -- Part IV: Psychological and Supporting Aspects of Recurrent Pregnancy Loss -- The healthcare giver's perspective -- The importance of emotional support for women with recurrent RPL -- A Patient's Perspective -- Part V: The Future -- New Frontiers in RPL research and treatment.
    Digital Access  Springer 2016
  • Print
    Jacqueline Woodson.
    Two families from different social classes are joined together by an unexpected pregnancy and the child that it produces. Moving forward and backward in time, with the power of poetry and the emotional richness of a narrative ten times its length, Jacqueline Woodson's extraordinary new nove uncovers the role that history and community have played in the experiences, decisions, and relationships of these families and in the life of this child. As the book open in 2001, it is the evening of sixteen-year-old Melody's coming-of-age ceremony in her grandparents' Brooklyn brownstone. Watched lovingly by her relatives and friends, making her entrance to the soundtrack of Prince, she wears a special custom-made dress. But the event is not without poignancy. Sixteen years earlier, that very dress was measured and sewn for a different wearer: Melody's mother, for her own ceremony - a celebration that ultimately never took place. Unfurling the history of Melody's parents and grandparents to show how they all arrived at this moment, Woodson considers not just their ambitions and successes but also the costs, the tolls they'e paid for striving to overcome expectations and escape the pull of history. As it explores sexual desire and identity, ambition, gentrification, education, class and status, and the life-altering facts of parenthood, Red at the Bone most strikingly looks at the ways in which young people must so often make long-lasting decisions about their lives - even before they have begun to figure out who they are and what they want to be. -- From dust jacket.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: DCORE (Downstairs DCORE)2019PS3573.O64524 R43 20191
  • Digital/Print
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Digital Access  Silverchair 1970-
    Latest ed. only
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)1970-<2012>RJ1 .R42713
  • Digital
    edited by David W. Kimberlin, MD, FAAP
    Fully revised and updated, the second edition of this full-color chart collects many of the most clinically useful tables, algorithms, and other items from the Red Book and presents them in an enlarged, enhanced, colorized format that is lightweight, portable, and easy to navigate
    Digital Access  AAP ebooks 2021
  • Digital
    editor, Carol J. Baker.
    Digital Access  ProQuest Ebook Central 2013
  • Digital
    editor, Carol J. Baker, MD, FAAP
    Digital Access  AAP ebooks 2020
  • Digital/Print
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Digital Access  Silverchair 1970-
    Latest ed. only
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)1970-<2012>RJ1 .R42713
  • Digital
    editor, David W. Kimberlin, MD, FAAP.
    This convenient flip chart provides pediatric health care professionals with point-of-care guidance on the assessment, prevention, and treatment of childhood infectious diseases. The content featured in these 15 information-rich tabs collects many of the most clinically useful tables, algorithms, and other items from the Red Book and presents them in an enlarged, enhanced, colorized format that is lightweight, portable, and easy to navigate.
    Digital Access  AAP ebooks 2019
  • Digital
    Sue Greenhalgh, James Selfe.
    Foreword -- Acknowledgements -- 1. Introduction -- 2. Communication -- 3. Osteoporosis : Diagnosis -- 4. Osteoporosis : Consequences and Care -- 5. Cauda Equina Syndrome : Diagnosis -- 6. Cauda Equina Syndrome : Consequences and Care -- 7. Metastatic Spinal Cord Compression (MSCC) -- 8. Metastatic Spinal Cord Compression (MSCC) : Consequences and Care.
    Digital Access  ClinicalKey Nursing 2019
  • Digital
    T. Pullaiah, S. Balasubramanya, M. Anuradha, editors.
    Pterocarpus santalinus L.f., popularly known as Red Sanders, an endemic tree, belonging to the family Fabaceae is confined to the southern parts of Eastern Ghats. IUCN has listed this tree as endangered. The plant has superlative characteristics in its wood and has many medicinal properties. This plant has attracted the attention of both foresters and lay man because of its high valued wood which is being illegally harvested creating law and order problem. This book is a comprehensive monograph on Red Sanders and is divided into 15 chapters. The book provides information on taxonomy, morphology, distribution, wood anatomy, wood properties and uses, dye principle, phytochemistry, pharmacology, Silvicultural aspects, propagation, cultivation practices, reproductive biology, pests and diseases, biotechnology, molecular studies, conservation, trade, commerce, socioeconomic aspects of Red Sanders, and grey areas of research. The book is profusely illustrated with colour photographs and line drawings. Relevant references have been provided under each chapter. This monograph on Red Sanders with systematic representation of information and illustrations will be a desk reference and field guide to foresters, botanists, researchers, farmers, traders and environmentalists.
    Digital Access  Springer 2019
  • Print
    Kimberly Allison.
    "Dr. Kimberly Allison diagnoses breast cancer for a living. But as a 33-year-old healthy new mother, she never expected to find herself looking at her own malignant cells under the microscope. Like many others diagnosed with cancer, Dr. Allison was starving for stories of other survivors. She wanted to hear someone's tale, to feel their experiences and look for hidden clues to what her own future might hold. Ultimately, the story that Dr. Allison was looking for was found in her own life. Red Sunshine is a memoir about Dr. Allison's sudden journey from physician to patient and her attempt to make the most of this terrifying and unexpected ordeal. Her experience reflects the incredible power of the bonds of friendship and family. It is about paying attention to the magic that is waiting to be uncovered in everyday life. Red Sunshine is an uplifting story of survival in which Dr. Allison shares all the intimate details of her emotional journey with both humor and honesty"-- Provided by publisher.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2011RC280.B6 A45 20111
  • Print
    Janet Mock.
    "In a landmark book, an extraordinary young woman recounts her coming-of-age as a transgender teen--a deeply personal and empowering portrait of self-revelation, adversity, and heroism. In 2011, Marie Claire magazine published a profile of Janet Mock in which she publicly stepped forward for the first time as a trans woman. Since then, Mock has gone from covering the red carpet for People.com to advocating for all those who live within the shadows of society. Redefining Realness offers a bold new perspective on being young, multiracial, economically challenged, and transgender in America. Welcomed into the world as her parents' firstborn son, Mock set out early on to be her own person--no simple feat for a young person like herself. She struggled as the smart, determined child in a deeply loving, yet ill-equipped family that lacked money, education, and resources. Mock had to navigate her way through her teen years without parental guidance but luckily with a few close friends and mentors she overcame extremely daunting hurdles. This powerful memoir follows Mock's quest for identity, from her early gender conviction to a turbulent adolescence in Honolulu that found her transitioning through the halls of her school, self-medicating with hormones at fifteen, and flying across the world for sex reassignment surgery at just eighteen. Ever resilient, Mock emerged with a scholarship to college and moved to New York City, where she earned her masters degree, basked in the success of an enviable career, and told no one about her past. It wasn't until Mock fell for a man who called her the woman of his dreams that she felt ready to finally tell her story, becoming a fierce advocate for girls like herself. A profound statement of affirmation from a courageous woman, Redefining Realness shows as never before what it means to be a woman today and how to be yourself when you don't fit the mold created for you."
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: DCORE (Downstairs DCORE)2014HQ77.8.M63 A3 20141
  • Digital
    John T. Tanacredi.
    This book provides insight into the basic aspects of ecology that impact or are affected by engineering practices. Ecological principals are described and discussed through the lens of the influences that built structures have on the Earth's biological, geological, and chemical systems. The text goes on to elucidate the engineering influences that have or will influence the face of the Earth. These influences redesign the Earth, either by destroying natural systems and replacing them with highly subsidized systems or by attempting to restore highly disturbed or contaminated systems with the basic natural systems that were originally present.
    Digital Access  Springer 2019
  • Digital/Print
    by Heidi M. Feldman.
    What are disabilities? -- Why focus on children with disabilities? -- What are the challenges in delivering health care to children with disabilities? -- Inclusion -- Contribution -- Health -- Focusing health care on function -- Comprehensive integrated care plans -- Family- and person-centered care -- Care coordination / with Alexis Hansen -- Changing professional education -- Research / with Nathan J. Blum -- Public policy.
    Digital Access  ProQuest Ebook Central 2013
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2013RC570 .F45 20131
  • Digital
    Romesh Kumar Salgotra, Sajad Majeed Zargar, editors.
    This book describes how the latest genomic resources techniques can be efficiently used in plant breeding programmes to achieve food security in the future. It also shares insights on how to utilize the untapped and unexplored genetic diversity of wild species, wild relatives and landraces for crop improvement. Moreover, the book offers an impressive array of balanced analyses, fresh ideas and perspectives, and thoughtful and realistic proposals regarding the sustainable utilization of plant genetic resources with modern biotechnological techniques. The first book to address the importance of plant genetics and genomic resources for food security, it brings together a group of plant breeders and biotechnologists to investigate the use of genomic resources techniques in plant breeding programmes. Providing essential information on the efficient utilization of genomic resources in precision breeding, it offers a valuable asset for undergraduate and graduate students, teachers and professionals engaged in related fields.
    Digital Access  Springer 2020
  • Digital
    Venkat R. Machiraju, Hartzell V. Schaff, Lars G. Svensson, editors.
    Digital Access  Springer 2012
  • Digital/Print
    edited by Judith P. Klinman.
    Digital Access  ScienceDirect 1995
  • Digital
    edited by Danyelle M. Townsend, Kenneth D. Tew.
    Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz -- Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki -- Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan -- Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend -- A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper -- Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik -- Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang -- Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.
    Digital Access  ScienceDirect 2014
  • Digital/Print
    edited by Chandan K. Sen, Lester Packer ; editorial advisory board, John F. Engelhardt ... [et al.].
    Digital Access  
    ProviderVersion
    ScienceDirectpt. A
    ScienceDirectpt. B
  • Digital
    Sanjib Kumar Panda, Yoshiharu Y. Yamamoto, editors.
    This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.
    Digital Access  Springer 2019
  • Digital
    edited by John T. Hancock.
    The role of redox in signal transduction / John T. Hancock -- The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence / Andrew G. Pinder ... [et al.] -- Detection and measurement of reactive oxygen intermediates in mitocondria and cells / Matthew Whiteman ... [et al.] -- Redox-sensitive green fluorescent protein : probes for dynamic intracellular redox responses : a review / Mark B. Cannon and S. James Remington -- Measuring redox changes in vivo in leaves : prospects and technical challenges / Philip M. Mullineaux and Tracy Lawson -- Imaging of intracellular hydrogen peroxide production with hyper upon stimulation of hela cells with Egf / Kseniya N. Markvicheva ... [et al.] -- Tools to investigate ROS sensitive signalling proteins / Radhika Desikan ... [et al.] -- Methods for preparing crystals of reversibly oxidized proteins : crystallization of protein tyrosine phophatase 1b as an example / Annette Salmeen and David Barford -- Methods for the study of redox-mediated changes in p53 structure and function / Kristine Mann -- Redox regulation and trapping sulphenic acid in the peroxide sensitive human mitochondrial branched chain aminotransferase / Susan M. Hutson ... [et al.] -- Detection of carbonylated proteins in 2-D SDS page separations / Rukhsana Sultana ... [et al.] -- Analysis of global and specific changes in the disulfide proteome using redox 2D-PAGE / Robert C. Cumming -- Protein-thiol oxidation from single proteins to proteome-wide analyses / Natacha Le Moan, Frédérique Tacnet, and Michel B. Toledano -- Analysis of redox relationships in the plant cell cycle : determinations of ascorbate, glutathione, and poly (ADPribose) polymerase (PARP) in plant cell cultures / Christine H. Foyer ... [et al.] -- Generation and detection of S-nitrosothiols / Christian Lindermayr, Simone Sell, and Jörg Durner.
    Digital Access  Springer 2008
  • Digital
    Toshiyuki Mori, Giovanni Dapri, editors.
    Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments. Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.
    Digital Access  Springer 2014
  • Digital
    edited by David G. Allen and Michael D. Waters.
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
    Digital Access  R Soc Chem 2013
  • Digital
    Marilyn Campbell, Sheri Bauman.
    Reducing Cyberbullying in Schools: International Evidence-Based Best Practices provides an accessible blend of academic rigor and practical application for mental health professionals, school administrators and educators, giving them a vital tool in stemming the problem of cyberbullying in school settings. It features a variety of international, evidence-based programs that can be practically implemented into any school setting. In addition, the book looks at a broad array of strategies, such as what can be learned from traditional bullying programs, technological solutions, policy and legal solutions, and more.
    Digital Access  ScienceDirect 2018
  • Digital
    Giovanni Landoni, Marta Mucchetti, Alberto Zangrillo, Rinaldo Bellomo, editors.
    Digital Access  Springer 2015
  • Digital
    Giovanni Landoni, Martina Baiardo Redaelli, Chiara Sartini, Alberto Zangrillo, Rinaldo Bellomo, editors.
    The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.
    Digital Access  Springer 2021
  • Digital
    Giovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.
    This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists.
    Digital Access  Springer 2014
  • Digital
    Giovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.
    The Risks and Benefits of the Consensus Process -- The Process of Consensus Building -- Noninvasive Ventilation to Reduce Perioperative Mortality -- Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality -- Can Neuraxial Anesthesia Reduce Perioperative Mortality -- Role of Perioperative Hemodynamic Optimization in Reducing Perioperative Mortality -- Levosimendan to Reduce Perioperative Mortality -- Perioperative b-Blocker Therapy and Survival -- Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality -- Reducing Perioperative Mortality with Intra-Aortic Balloon Counterpulsation (IABP) -- Selective Decontamination of the Digestive Tract -- Role of Insulin in Reducing Mortality in the Perioperative Period -- Aprotinin: Pharmacological Benefits and Safety Concerns -- Consensus Conference on Perioperative Mortality: An Update -- Liberal Transfusion Strategy in the Perioperative Period -- Remote ischaemic preconditioning -- Statins -- Tranexamic acid -- Proven mortality reduction unconfirmed in most recent works. methodological problem.
    Digital Access  Springer 2017
  • Digital
    Arden Handler, Joan Kennelly, Nadine Peacock, editors.
    Introduction: challenges in reducing disparities in reproductive and perinatal outcomes through evidence-based public health -- Methodological approach to assessing the evidence -- Evidence-based public health: origins, assumptions, and cautions -- Access to family planning and induced abortion -- Preconceptional health promotion -- Infertility status and infertility treatment: racial and ethnic disparities -- Public health interventions for perinatal HIV and STI screening in pregnancy -- What is the role of prenatal care in reducing racial and ethnic disparities in pregnancy outcomes? -- Current approaches to reducing premature births and implications for disparity elimination -- Prenatal case management of pregnant women: what is the evidence for its contribution to a reduction of disparities in perinatal outcomes? -- Behavioral treatment methods for pregnant smokers: the evidence base for prenatal care programs and professional practice -- Substance abuse in pregnancy: the impact of screening and treatment on improving perinatal outcomes and reducing racial and ethnic disparities -- The evidence for perinatal depression screening and treatment -- Supplemental nutrition programs during pregnancy and the early postnatal period -- Group prenatal care and doula care for pregnant women -- Contemporary childbirth in the United States: interventions and disparities -- Regionalized perinatal care: an evidence-based intervention in development.
    Digital Access  Springer 2011
  • Digital
    Raj Mathur, editor.
    1. The Challenges of Multiple Pregnancies -- 2. Prognosis of Risks for Offspring of Fertility Treatment -- 3. Ovarian Hyperstimulation Syndrome -- 4. Thromboembolism Associated with Fertility Treatment -- 5. Emotional and Psychosocial Risk Associated with Fertility Treatment -- 6. Regulatory and Legal Risks for Patients.
    Digital Access  Springer 2015
  • Digital/Print
    edited by Salvatore Vaccarella [and 5 others].
    This volume summarizes the current scientific evidence and identifies research priorities needed to decrease social inequalities in cancer. The publication, based on the expert knowledge of more than 70 international scientists from multiple disciplines, undertakes a populations-within-populations approach, highlighting the large variations in cancer incidence, survival, and mortality that exist between countries and, within countries, between social groups. Several factors may lead individuals with low social status to adopt unhealthy behaviors, to be exposed to a wider range and a higher intensity of cancer risk factors, and to have reduced access to health-care services, compared with their fellow citizens. A special focus is given to how the phenomenon of inequalities in cancer evolves and is reshaped over time, driven by economic, social, political, legislative, and technological forces; it affects everyone, but the most disadvantaged individuals are particularly hard hit. This IARC Scientific Publication was developed to serve as a reference for policy-makers and public health officials, linking to specific examples of interventions that may reduce future inequalities in cancer.
    Digital Access   2019
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2019RA645.C3 R43 20191
  • Digital
    edited by S.H. Fatemi.
    Digital Access  Springer 2008
  • Print
    edited by George Stachokas.
    Trends and developments in licensing electronic resources / by Lori Duggan -- Oh, the places you'll go! : managing electronic resources across the institution / by Monica Moore -- Managing knowledge bases and electronic resources metadata / by Richard Guajardo -- Working with EBSCO discovery service / by Regina Koury -- Managing discovery services : case studies at Simon Frasier University (Summon) and Acadia University (Primo) / by Leanna Jantzi, Jennifer Richard, and Sandra Wong -- From electronic resources management to library services platforms / by L. Angie Ohler -- The library in the information marketplace : cost containment strategies / by George Stachokas -- Using LibGuides to promote communication between public and technical services / by Jennifer Bazeley -- Core competencies for electronic resources librarianship / by Sarah W. Sutton -- Using the core competencies for e-resource librarians to reengineer technical services / by Christine Korytnyk Dulaney and Kari Schmidt -- Is "E" for everybody? : reorganizing to fit e-resources across acquisitions and resource sharing / by Judith Emde and Angela Rathmel -- Managing freely available electronic resources / by Chris Bulock -- Developing staff skills in e-resource troubleshooting : training, assessment, and continuous progress / by Sunshine Carter and Stacie A. Traill -- SUSHI : automating the retrieval of COUNTER usage data / by Oliver Pesch -- Analytics and assessment of electronic resources / by Geoffrey Timms.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Staff Library Literature Collection (non-circulating)2018Z692.C65 R44 20181
  • Digital
    Lamia Soghier, editor
    Completely updated, this popular pocket guide provides commonly used reference ranges and values spanning birth through adolescence; plus, data needed for treatment of preterm and other newborns.
    Digital Access  AAP ebooks 2019
  • Digital
    edited by Rainer Hofmann-Wellenhof, Giovanni Pellacani, Joseph Malvehy, Hans Peter Soyer.
    Part 1. Confocal Reflectance Microscopy - the Essentials -- The Confocal Story -- How Reflectance Confocal Microscopy Works -- A Hands-on Guide to Confocal Imaging -- Part 2. Normal Skin -- Epidermis, Dermis and Epidermal Appendages -- Acral Volar Skin, Facial Skin and Mucous Membrane -- Part 3. Melanocytic lesions -- Semeiology and Pattern Analysis in Melanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Part 4. Melanocytic lesions: Nevi -- Common Nevi -- Atypical/Dysplastic Nevi -- Spitz Nevi -- In Vivo Confocal Reflectance Microscopy of Congenital Melanocytic Nevi -- The Many Faces of Nevi: Blue, "Black" and Recurrent Nevi -- Part 5. Melanocytic lesions: Melanoma -- Superficial Spreading Melanoma -- Melanoma Progression -- Nodular Melanoma -- Lentigo Maligna -- Amelanotic Melanoma -- Part 6. Non-melanocytic Skin Lesions -- Semiology and Pattern Analysis in Nonmelanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Solar Lentigo, Seborrheic Keratosis and Lichen Planus-Like Keratosis -- Basal Cell Carcinoma -- Actinic Keratosis -- Squamous Cell Carcinoma -- Cutaneous Lymphoma -- Potpourri of Nonmelanocytic Skin Lesions -- Part 7. Inflammatory Skin Diseases -- The Semiology and Patterns of Inflammatory Skin Conditions -- Hyperkeratotic Dermatitis -- Spongiotic Dermatitis -- Interface Dermatitis -- Pigmentary Skin Disorders -- Part 8. Monitoring of Skin Lesions and Therapy Control -- Follow-up of Nevi -- Monitoring of Nonsurgical Treatment of Skin Tumors -- Confocal Mosaicing Microscopy in Skin Excisions: Feasibility of Cancer Margin Screening at the Bedside to Guide Mohs Surgery -- Reflectance Confocal Microscopy Applications in Cosmetology -- Part 9. Future Aspects -- Tele-Reflectance Confocal Microscopy -- Automated Diagnosis and Reflectance Confocal Microscopy -- Experimental Applications and Future Directions -- Part 10. Glossary -- Reflectance Confocal Microscopy Imaging: A Glossary of Terminology.
    Digital Access  Springer 2012
  • Digital
    Marc Maesschalck.
    RRI and Governance Theory -- The Origins of Governance Theory -- Exploring Reflexive Governance Theory -- Key Strengths of a Reflexive Theory of Governance -- Promoting Reflexive Governance of RRI -- Intellectual Intervention in Society: The Key to Reflexive Governance of RRI.
    Digital Access  Wiley 2017
  • Digital
    Denise Tiran ; foreword by Maggie Evans.
    An introduction to the subject of reflexology and, specifically, to structural reflex zone therapy, including a revision of the zones and points on the feet which are used in treatment and its application to the care of pregnant, childbearing and newly-delivered mothers.
    Digital Access  ScienceDirect 2010
  • Digital
    Alyn H. Morice, Peter W. Dettmar, editors.
    This book is about the interface between reflux and the respiratory tract. Reflux is an important factor in many different lung diseases. The pathological basis of reflux has recently undergone major changes in our understanding based on improved diagnostic technology. Readers will learn about how reflux impacts on many common lung conditions. Special circumstances such as eosinophilic inflammation in relation to asthma, cough, and eosinophilic bronchitis will be highlighted. Particular attention is also given to previously unrecognised role of non-acid "airway" reflux. Additionally, pharmacological, surgical and behavioural techniques for diagnostic and treatment are explored witin these chapters This book offers a comprehensive overview of various research areas in reflux in relation to airways disease, since currently there is no summary of how the different but overlapping areas impacted by reflux affect the respiratory tract. It will be of great interest to respiratory physicians, otorhinolaryngologists, and gastroenterologists. .
    Digital Access  Springer 2018
  • Digital
    Vassilios Raikos, Viren Ranawana, editors.
    This work introduces the concept of reformulation, a relatively new strategy to develop foods with beneficial properties. Food reformulation by definition is the act of re-designing an existing, often popular, processed food product with the primary objective of making it healthier. In recent years the concept of food reformulation has evolved significantly as additional benefits of re-designing food have become apparent. In addition to targeting specific food ingredients that are considered potentially harmful for human health, food reformulation can also be effectively used as a strategy to make foods more nutritious by introducing essential macro- /micro-nutrients or phytochemicals in the diet. Reformulating foods can also improve sustainability by introducing "waste" (and underutilized) ingredients into the food chain. In light of these developments, reformulating existing foods is now considered a realistic and attractive opportunity to provide healthy, nutritious, and sustainable food choices to the consumers and likewise improve public health. Indeed reformulation has now become essential in many cases for redressing the health properties of foods that are popularly consumed and significantly affecting public health. This edited volume covers aspects of food reformulation from various angles, exploring the role of the food industry, academia, and consumers in developing new products. Some of the major themes contributors address include methods of reformulating food products for health, improving the nutritional composition of foods, and challenges to the food industry, including regulation as well as consumer perception of new products. The book presents several case studies to clarify these objectives and illustrate the difficulties encountered in the process of developing a reformulated product. Chapters from experts in the field identify emerging and future trends in food product development, and highlight ways in which these efforts will help with increasing food security, improving nutrition and health, and promoting sustainable production. The editors have designed the book to be useful for both industry professionals and the research community. This interdisciplinary approach incorporates a wide spectrum of food sciences (including composition, engineering, and chemistry) as well as nutrition and public health. Food and nutrition professionals, policy makers, health care and social scientists, and graduate students will also find the information relevant.
    Digital Access  Springer 2019
  • Digital
    [edited by] Dimitri T. Azar ; associate editors, Damien Gatinel, Ramon C. Ghanem, Suphi Taneri.
    Terminology, classification, and history of refractive surgery -- Corneal wound healing following keratorefractive surgery -- Physiologic optics for refractive surgery : an overview -- Corneal topography -- Wavefront analysis -- Optical coherence tomography in refractive surgery -- Excimer lasers -- Laser and mechanical microkeratomes -- Crosslinking instrumentation -- Ocular diseases of importance to the refractive surgeon -- Patient evaluation for refractive surgery -- Preoperative evaluation of keratoconus and ectasia -- LASIK, Q-based, and wavefront-guided LASIK for myopia, hyperopia, and astigmatism -- LASIK and TopoLink for irregular astigmatism -- LASIK complications and their management -- Small-incision lenticule extraction (SMILE) -- Small-incision lenticule extraction (SMILE) complications and their management -- Photorefractive keratectomy -- Lasek and epi-LASIK -- Phototherapeutic keratectomy (PTK) and intralamellar PTK -- Principles of corneal cross-linking -- Epithelium off and transepithelial cross-linking : techniques and outcomes -- Orthokeratology -- Radial and astigmatic keratotomy -- Conductive keratoplasty and laser thermokeratoplasty -- The intrastromal corneal ring segments -- Intraocular lens calculations after keratorefractive surgery -- Phakic intraocular lens power calculations -- Refractive lens exchange -- Iris-fixated phakic intraocular lenses -- Posterior chamber phakic intraocular lens -- Complications of phakic intraocular lenses -- Phakic intraocular lens explantation (PIOL) : causes and surgical techniques of PIOL exchange and bilensectomy -- Physiology of accommodation and presbyopia -- Monovision -- Scleral surgery for presbyopia -- Multifocal corneal surgery for presbyopia -- Corneal implants and inlays -- Multifocal intraocular lenses -- Refractive surgical procedures to restore accommodation -- Smart intraocular lenses, accommodating and pseudoaccommodating intraocular lenses for presbyopia -- Postkeratoplasty astigmatism : etiology, management, and femtosecond laser applications.
    Digital Access  ClinicalKey 2020
  • Digital/Print
    [edited by] Louis E. Probst, John F. Doane.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2001RE336 .R45 20011
  • Digital
    Georgia Malamut, Nadine Cerf-Bensussan, editors.
    This book is about recurring celiac disease its diagnosis and management. It starts by discussing the pathogenesis of refractory celiac disease and the role of viruses, microbiota and genetics in this disease. It also covers the epidemiological aspects. Refractory Celiac Disease is a unique resource on the topic written by a team of international experts in the topic and will be of great use to gastroenterologists and researchers in the field.
    Digital Access  Springer 2022
  • Digital
    Xuefeng Wang, Shichuo Li, editors.
    Digital Access  Springer 2017
  • Digital
    Aniyizhai Annamalai, editor.
    "Physicians receive very little training in refugee health. Refugee Health Care is a practical guide providing concise information for busy practitioners. This concise textbook reviews common conditions seen in refugees and some of the recommendations in the book apply to all immigrants. It will be a valuable resource for primary care physicians, psychiatrists, pediatricians, women's health providers and any health care practitioner who treats refugees."--Publisher's website.
    Digital Access  Springer 2014
  • Digital
    edited by Aniyizhai Annamalai.
    Refugee health is growing as an academic medical discipline. More and more health care providers are coming together to exchange research information, educational curricula and social policies related to refugee health. The number of practitioners attending the annual North American Refugee Healthcare Conference has doubled since 2014. Refugees arrive in the United States from different parts of the world. Refugees undergo a medical screening soon after arrival, as recommended by the U.S. Department of State, and it is usually primary care practitioners who usually evaluate these patients at this first visit. Psychiatrists and other specialists may also evaluate them soon after arrival.Though physicians receive a variable amount of training in cross-cultural medicine, virtually none is in the area of refugee evaluations. There are several major ways that the field has changed. U.S. refugee policies and refugee admission numbers have changed dramatically in the past four years as has the epidemiology of medical conditions because the demographics of refugees have changed. The CDC guidelines for domestic screening have also been modified significantly as some of the screening tests are no longer recommended. Protocols have also been updated for presumptive treatment received by refugees before departure to the United States of other countries. A new chapter on end of life care for refugees has been added to the book. Now fully revised and expanded, this second edition reflects the many changes that have occurred in the field of refugee health since 2014. Refugee Health Care remains the definitive resource for primary care physicians and mental health practitioners who see and evaluate refugees. It is also relevant for medical, nursing and public health students involved with refugee health as well as resettlement agency workers and public health officials overseeing refugee care.
    Digital Access  Springer 2020
  • Digital
    Ira S. Cohen, Glenn R. Gaudette, editors.
    Inducing embryonic stem cells to become cardiomyocytes / Alexander M. Becker, Michael Rubart, and Loren J. Field -- Regenerating function in vivo with myocytes derived from embryonic stem cells / Priya R. Baraniak and Todd C. McDevitt -- Excitation-contraction coupling, functional properties, and autonomic and hormonal regulation in human embryonic stem cell derived cardiomyocytes / Oshra Sedan and Ofer Binah -- Embryonic stem cell derivatives for cardiac therapy : advantages, limitations, and long-term prospects / Michal Weiler-Sagie and Lior Gepstein -- Methods for differentiation of bone-marrow-derived stem cells into myocytes / Shinji Makino and Keiichi Fukuda -- Homing, survival, and paracrine effects of human mesenchymal stem cells / Sergey Doronin -- Bone marrow cell therapy after myocardial infarction : what have we learned from the clinical trials and where are we going? / Kai C. Wollert -- Evidence for the existence of resident cardiac stem cells / Isotta Chimenti ... [et al.] -- Multiple sources for cardiac stem cells and their cardiogenic potential / Antonio Paolo Beltrami, Daniela Cesselli, and Carlo Alberto Beltrami -- Skeletal muscle stem cells in the spotlight : the satellite cell / Zipora Yablonka-Reuveni and Kenneth Day -- Regenerating mechanical function in vivo with skeletal myoblasts / Todd K. Rosengart and Muath Bishawi -- Methods for inducing pluripotency / Raymond L. Page, Christopher Malcuit, and Tanja Dominko -- Inducible pluripotent stem cells for cardiac regeneration / Naama Zeevi-Levin and Joseph Itskovitz-Eldor -- Induced pluripotent cells for myocardial infarction repair / Timothy J. Nelson and Andre Terzic -- Substrates of cardiac reentrant arrhythmias : the possible role of tissue regeneration and replacement / André G. Kléber -- Integration of stem cells into the cardiac syncytium : formation of gap junctions / Peter R. Brink, Ira S. Cohen, and Richard T. Mathias -- Bradyarrhythmia therapies : the creation of biological pacemakers and restoring atrioventricular node function / Richard B. Robinson -- Tachyarrhythmia therapies : approaches to atrial fibrillation and postinfarction ventricular arrhythmias / J. Kevin Donahue and Kenneth R. Laurita -- Long-term prospects for arrhythmia treatment : advantages and limitations of gene and cell therapies / Michael R. Rosen -- Regenerating blood vessels / Tracy A. Gwyther and Marsha W. Rolle -- Regenerating heart valves / Benedikt Weber and Simon P. Hoerstrup -- Tissue engineering strategies for cardiac regeneration / Amandine F.G. Godier-Furnémont ... [et al.] -- Methods of cell delivery for cardiac repair / Sarah Fernandes and Hans Reinecke -- Tracking of stem cells in vivo / Yingli Fu and Dara L. Kraitchman -- Assessing regional mechanical function after stem cell delivery / Jacques P. Guyette and Glenn R. Gaudette.
    Digital Access  Springer 2011
  • Digital
    Sepanta Hosseinpour, Laurence J. Walsh, Keyvan Moharamzadeh, editors.
    This book provides evidence-based information in the field of regenerative dentistry discussing the most recent advances, current clinical applications, limitations and future directions. The coverage encompasses the regeneration of alveolar bone, the dentine-pulp complex, enamel, the periodontium and other tissues associated with the oral cavity. A full description is provided of regenerative approaches in dentistry including regenerative endodontics and tooth repair, regenerative periodontics, regenerative assisted orthodontics, regenerative approaches in oral medicine, and dental tissue derived stem cells and their potential applications. The book is written by an international team of leading experts. It will be beneficial for students, practitioners and researchers in the fields of endodontics, periodontics and implantology.
    Digital Access  Springer 2021
  • Digital
    David L. Stocum.
    Digital Access  ScienceDirect 2012
  • Digital/Print
    edited by Rahul Jandial, Mike Y. Chen ; associate editors, Bihong T. Chen, Joseph Ciacci.
    Frontiers of spinal cord and spine repair : experimental approaches for repair of spinal cord injury / Choya Yoon and Mark H. Tuszynski -- Stem cell based strategies for spinal cord injury repair / Alexa Reeves and Hans S. Keirstead -- Strategies for endogenous spinal cord repair : HPMA hydrogel to recruit migrating endogenous stem cells / Araceli Espinosa-Jeffrey ... [et al.] -- Stem cells and spinal cord injury repair / Soheila Karimi-Abdolrezaee and Eftekhar Eftekharpour -- Chronic pain following spinal cord injury / Radi Masri and Asaf Keller -- Repair of radiation damage and radiation injury to the spinal cord / Timothy E. Schultheiss -- Malignancies of the spinal cord / J. Dawn Waters, Encarnacion Maria Navarro Peran, and Joseph Ciacci -- Molecular basis of intervertebral disc degeneration / Dipika Gopal ... [et al.] -- Bioceramics for osteogenesis, molecular and cellular advances / Hande Demirkiran -- Cell-based therapies for spinal fusion / Ronke Olabisi -- Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering / Josh Neman ... [et al.] -- Progenitor cells : role and usage in bone tissue engineering approaches for spinal fusion / Lonnissa H. Nguyen ... [et al.].
    Digital Access  Springer 2012
  • Digital
    Suad Trebinjac, Manoj Kumar Nair.
    This book sheds new light on the complex area of regenerative injections used in sports injuries and musculoskeletal conditions, pursuing an evidenced-based approach. Largely ignoring orthopedic surgery, which would involve arthroscopic procedures and scaffolding as they are practiced mainly by orthopedic surgeons, the book instead focuses on injection-based treatments that are particularly useful in sports medicine and for musculoskeletal pain conditions. Including evidence from systematic reviews, meta-analyses, and randomized controlled trials, the book provides a comprehensive overview of regenerative injections such as dextrose, platelet-rich plasma and stem cell therapy, along with their history and scientific basis. It also includes detailed information on the preparation methods, steps of the procedure, and clinical conditions most likely to benefit from it. Given its scope, the book offers a valuable tool for all medical practitioners whose work involves painful musculoskeletal conditions, e.g. sports medicine physicians, orthopedists and interventional physiatrists, as well as general practitioners.
    Digital Access  Springer 2020
  • Digital
    Gustav Steinhoff, editor.
    Digital Access  Springer 2011
  • Digital
    Niranjan Bhattacharya, Phillip George Stubblefield, editors.
    This book represents a major contribution to the emerging science of regenerative medicine using non-fetal sources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have brought together some of the most pre-eminent scientists working on regenerative medicine to share information on currently ongoing work in this area alongside unpublished observations that will help to shape the contours of future therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem Cells discusses the potential clinical and therapeutic applications using non-fetal stem cells as well as providing instruction on the collection, isolation and characterization of stem cells from various non-fetal sources, such as menstrual blood, adipose tissue, breast milk and uprooted decidual teeth. This book will be an invaluable resource for both active researchers and those entering the field. The Editors truly hope that the text will act as a stimulant to professionals and clinical scientists, who may be inspired to further the work of the pioneering scientists who have contributed to this volume.
    Digital Access  Springer 2015
  • Digital
    Hossein Baharvand, Nasser Aghdami, editors.
    1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
    Digital Access  Springer 2013
  • Digital
    Dominik Duscher, Melvin A. Shiffman, editors.
    This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields."--Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine.
    Digital Access  Springer 2019
  • Digital
    Dominik Duscher, Melvin A. Shiffman, editors.
    This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The books third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction."--Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine.
    Digital Access  Springer 2019
  • Digital
    [edited by] Giuseppe Orlando, Jan Lerut, Shay Soker, Robert J. Stratta.
    Principles of regenerative medicine and cell,tissue and organ bioengineering -- Kidney -- Liver -- Heart -- Small bowel -- Endocrine pancreas and islets of langerhans -- Lung -- Composite tissues allotranplantation -- Immunosuppression-free transplantation in the regenerative medicine era.
    Digital Access  ScienceDirect 2014
  • Digital
    Linda F. Hogle, editor.
    Regenerative medicine is at a pivotal point. Innovations in the science and the rapid growth of translational medicine are transforming the field just as institutional arrangements are changing, making this an exciting yet unsettled time. Recent court cases and policy initiatives are creating crosscurrents that keep older issues from being settled while introducing new dilemmas. Current research propels collaborations across disciplines and sectors, raising the question of how tensions between the protection of intellectual property and the movement toward "open science" can be negotiated. Other important social, ethical and legal questions arise in the gray areas created by new scientific techniques and pragmatic areas involved in scale-up and testing in humans. The times call for governance that is adaptive to meet the needs of science yet able to maintain public trust. The contributors address these and other vital questions through chapters focusing on topics such as data sharing; patenting of human biological material; and managing collaborations across academic, industry and government sectors as well as across national boundaries. Key research ethics issues are also included such as obtaining consent from biospecimen donors; accessing biorepository data, and considerations in designing preclinical and clinical trial protocols for first-in-human research, including upcoming policy changes. Rather than retracing well-trodden topics, the book points to nascent areas that need to be addressed. Whether working in academia, industry, or government, regenerative medicine scientists and managers need to know how to navigate current and upcoming issues of governance facing the field. Regenerative Medicine Ethics: Governing Research and Knowledge. Practices will be a valuable resource for scientists, policy-makers and students as they plan and execute responsible research.
    Digital Access  Springer 2014
  • Digital
    Grant Cooper, Joseph Herrera, Jason Kirkbride, Zachary Perlman, editors.
    Regenerative medicine (RM) is a rapidly expanding topic within orthopedic and spine surgery, sports medicine and rehabilitation medicine. In the last ten years, regenerative medicine has emerged from the fringes as a complement and challenge to evidence-based medicine. Both clinicians and patients alike are eager to be able to offer and receive treatments that don't just surgically replace or clean old joints or inject away inflammation or work as a stop-gap measure. Regenerative medicine encompasses everything from the use of stem cells and platelet-rich plasma (PRP) to prolotherapy, viscosupplementation and beyond. This book will provide healthcare practitioners dealing with spine and joint pain with the most current, up-to-date evidence-based information about which treatments work, which treatments don't, and which are on the horizon as potential game changers. Chapters are arranged in a consistent format and cover the spine, shoulder, elbow, hand and wrist, hip, knee, and foot and ankle, providing a thorough, top-to-bottom approach. A concluding chapter discusses current and future directions and applications of RM over the next decade or two. Timely and forward-thinking, Regenerative Medicine for Spine and Joint Pain will be a concise and practical resource for orthopedists, spine surgeons, sports medicine specialists, physical therapists and rehabilitation specialists, and primary care providers looking to expand their practice.
    Digital Access  Springer 2020
  • Digital
    Juichi Ito, editor.
    The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
    Digital Access  Springer 2014
  • Digital
    Xiaobing Fu, editor.
    This book includes major issues in wound tissue repair and regeneration in 14 chapters. The topics start from cytological basis, molecular and genetic basis, skin development, to the tissue repair, visceral injury and tissue engineering. In the second part, it introduces Chinese researchers contribution in wound repair and regeneration. Specially, it has 3 chapters discussing new technologies in tissue repair and regeneration, and 1 chapter in Traditional Chinese Medicine.
    Digital Access  Springer 2021
  • Digital
    Juichi Ito, editor.
    Preface -- Part 1: Current siguation of the regenerative medicine -- Chapter 1: Current siguation of the regenerative medicine -- Part 2: Development and regeneration of the ear.- Chapter 2: The innner ear -- Chapter 3: Regeneration of the Soft Tissue Defects of the External Auditory Meatus -- Chapter 4: Regeneration of the Tympanic Membrane -- Chapter 5: An approach in regenerative medicine for the treatment of intractable otitis media -- Chapter 6: Peripheral Nerve Regeneration by Tissue Engineering for Prevention of Misdirection -- Part 3: Development and regeneration of the nose and the paranasal sinuses -- Chapter 7: Development and regeneration of the nose and the paranasal sinuses -- Part 4: Development and regeneration of the oral cavity and the pharynx -- Chapter 8: Development and regeneration of the oral cavity and the pharynx -- Part 5: Development and regeneration of the larynx -- Chapter 9: Laryngeal Development -- Chapter 10: Laryngeal framework regeneration -- Chapter 11: Vocal folds Development -- Chapter 12: Regeneration of the vocal fold -- Part 6: Development and regeneration of the head & neck -- Chapter 13: Cranial bone regeneration -- Chapter 14: Salivary gland development and regeneration -- Chapter 15: Regeneration of the Trachea -- Chapter16: Future perspective.
    Digital Access  Springer 2015
  • Digital
    Hernán Pinto, Joan Fontdevila, editors.
    This book presents the state-of-art in regenerative procedures currently applied by aesthetic physicians, plastic surgeons and dermatologists. It is divided into two parts, the first of which provides a detailed introduction to aesthetic medicine and the aging process. The second part, in turn, addresses the current status of techniques and technologies with regard to autologous grafts, covering fat transfer, blood grafts, skin grafts and stem cells. The book examines the surgical applications of these grafts, as well as potential side effects and limitations. Therapy combinations and outcomes round out the coverage. Aesthetic physicians, plastic surgeons and dermatologists interested in performing regenerative procedures for aesthetic purposes will find this book to be a valuable guide. -- Provided by publisher.
    Digital Access  Springer 2019
  • Digital
    Niranjan Bhattacharya, Phillip Stubblefield (editors).
    A massive wastage of the global resources -- Placenta as a source of stem cells and as a key organ for fetomaternal tolerance -- Placenta and umbilical cord in traditional Chinese medicine -- Use of umbilical venous blood on assessing the biochemical variations of acid-base, nutritional and metabolic parameters on growth-retarded fetuses, in comparison with gestational control cases: a study -- Umbilical cord blood transfusion and its therapeutic potentialities -- Autologous placental blood transfusion for the therapy of anemic neonates -- Cord blood: a massive waste of a life-saving resource: a perspective on its current and potential uses -- Clinical experience of cord blood autologous transfusion -- Emergency use of human cord blood -- Hemoglobin-based oxygen carriers in trauma care: the US multicenter prehospital trial -- Placental umbilical cord blood as a true blood substitute with an edge -- Implications of feto-maternal cell transfer in normal pregnancy -- Early reports on the prognostic implications and immunotherapeutic potentials of Cd34 rich cord whole blood transfusion in advanced breast cancer with severe anemia -- Anti-inflammatory effects of human cord blood and its potential implications in neurological disorders -- Transforming "waste" into gold: identification of novel stem cells resources with therapeutic potential in neuromuscular disorders -- Human umbilical cord blood cells for stroke -- Placental umbilical cord blood transfusion for stem cell therapy in neurological diseases -- Umbilical cord and its blood: a perspective on its current and potential use in ophthalmology -- Umbilical vein grafts for lower limb revascularization -- Cord blood stem cells in angiogenesis. Endothelial progenitor cells from cord blood: magic bullets against ischemia? -- Therapeutic potential of placental umbilical cord blood in cardiology -- Stem cell therapy for heart failure using cord blood -- Human umbilical cord blood mononuclear cells in the treatment of acute myocardial infarction -- Umbilical cord-derived mesenchymal stem cells -- Cord blood stem cell expansion ex vivo: current status and future strategies -- Embryonic-like stem cells and the importance of human umbilical cord blood for regenerative medicine -- Use of non-hematopoietic stem cells of fetal origin from cord blood, umbilical cord, and placenta in regeneration medicine -- Animal studies of cord blood and regeneration -- Immune privilege of cord blood -- Combination cellular therapy for regenerative medicine: the stem cell niche -- Use of cord blood in regenerative medicine -- Comparisons between related and unrelated cord blood collection and/or banking for transplantation or research: the UK NHS blood and transplant experience -- Donor and collection-related variables affecting product quality in ex utero cord blood banking -- Cord blood as a source of hematopoietic progenitors for transplantation -- Amniotic fluid and placenta stem cells -- Use of amniotic membrane, amniotic fluid, and placental dressing in advanced burn patients -- Clinical use of amniotic fluid in osteoarthritis: a source of cell therapy -- A study and follow-up (1999-2009) of human fetal neuronal tissue transplants at a heterotopic site outside the brain in cases of advanced idiopathic Parkinsonism -- Ethical issues surrounding umbilical cord blood donation and banking.
    Digital Access  Springer 2011
  • Digital
    edited by Michael S. Goligorsky.
    Chapter 1. Glomerulogenesis and De Novo Nephrogenesis in Medaka Fish: An Evolutionary Approach / Hisashi Hashimoto, Yuko Wakamatsu -- Chapter 2. Renal Organogenesis: Growing a Replacement Kidney In Situ from Transplanted Renal Primordia / Marc R. Hammerman -- Chapter 3. Use of Genetic Mouse Models to Study Kidney Regeneration / Akio Kobayashi, Jeremy S. Duffield -- Chapter 4. Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease / Charles N. Serhan, Catherine Godson -- Chapter 5. Tissue Protection and Regeneration Aided by Erythropoietin and Erythropoietin-derived Peptides / Danilo Fliser -- Chapter 6. Mast Cells in Kidney Regeneration / Eric Daugas, Walid Beghdadi, Ulrich Blank -- Chapter 7. Role of Macrophages in Renal Injury, Repair and Regeneration / Vincent Lee, Qi Cao, Yiping Wang, David C.H. Harris -- Chapter 8. T-cell Contribution to Injury and Regenerative Processes in Kidney Diseases: Focus on Regulatory T Cells / Hye Ryoun Jang, Hamid Rabb -- Chapter 9. Mesenchymal Stem Cells / Benjamin D. Humphreys, Joseph V. Bonventre -- Chapter 10. Endothelial Progenitor Cells and the Kidney / Matthieu Monge, Anton Jan van Zonneveld, Ton J. Rabelink -- Chapter 11. Potential of the Side Population in Regenerative Nephrology / M.H. Little, G.A. Challen -- Chapter 12. Very Small Embryonic-like Stem Cells and Their Potential Relevance for Kidney Homeostasis / Dong-Myung Shin, Rui Liu, Przemyslaw Nowacki, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak -- Chapter 13. Induced Pluripotent Stem Cells / Kenji Osafune, Shinya Yamanaka -- Chapter 14. Methods of Isolation and Culture of Adult Stem Cells / Lindolfo da Silva Meirelles, Nance Beyer Nardi -- Chapter 15. Stem Cell Niche in the Kidney / Laura Lasagni, Elena Lazzeri, Paola Romagnani -- Chapter 16. Bioartificial Stem Cell Niches: Engineering a Regenerative Microenvironment / Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff, Michael S. Goligorsky -- Chapter 17. Imaging of Transplanted and Native Stem Cells / Xiang-Yang Zhu, Martin Rodriguez-Porcel, Lilach O. Lerman -- Chapter 18. Stem Cell Injury and Premature Senescence / Michael S. Goligorsky -- Chapter 19. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway / Nica M. Borradaile, Alanna Watson, J. Geoffrey Pickering -- Chapter 20. Bone Marrow Mesenchymal Stem Cells in Organ Repair and Strategies to Optimize their Efficacy / Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi, Marina Morigi -- Chapter 21. Treatment of Acute Kidney Injury with Allogeneic Mesenchymal Stem Cells: Preclinical and Initial Clinical Data / Florian E. Tögel, Christof Westenfelder -- Chapter 22. Clinical Trials in Renal Regenerative Medicine / Maarten B. Rookmaaker, Jaap A. Joles, Marianne C. Verhaar -- Chapter 23. Potential Risks of Stem Cell Therapies / Uta Kunter, Jürgen Floege -- Chapter 24. Tissue Engineering in Urology / Anthony Atala -- Chapter 25. Ethics in Regenerative Medicine / Svetlana Gavrilov, Donald W. Landry -- Chapter 26. Stem Cell Banking / Vicente Mirabet, Pilar Solves.
    Digital Access  ScienceDirect 2011
  • Digital
    James C. Melville, Jonathan W. Shum, Simon Young, Mark E. Wong, editors.
    This book is designed as a comprehensive and up-to-date instructional guide to the strategies employed for regeneration of the maxillomandibular region, with emphasis on allogeneic and tissue engineering principles. Readers will find information on indications and contraindications for procedures, pertinent anatomy, surgical techniques, postoperative management, and management of complications. Current surgical techniques utilizing biotechnology for regeneration and reconstruction are described in depth, with explanation of their benefits in minimizing patient morbidity. In addition, state of the art free vascular transfer for maxillary and mandibular reconstruction is extensively discussed, with a particular focus on indications and step-by-step technique. The authors are well-known experts in their field who are keen to share their extensive experience and preferred approaches. The book is intended for all oral and maxillofacial surgeons, head and neck surgeons, and plastic and reconstruction surgeons who wish to increase their knowledge on the latest modalities of maxillary and mandibular reconstruction.
    Digital Access  Springer 2019
  • Digital
    David S. Allan, Dirk Strunk, editors.
    Digital Access  Springer 2012
  • Print
    George Church & Ed Regis.
    From bioplastics to H. sapiens 2.0 -- -3,800 Myr, Late Hadean : at the inorganic/organic interface -- -3,500 Myr, Archean : reading the most ancient texts and the future of living software -- -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be? -- -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum" -- -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering -- -30,000 Yr, Pleistocene Park : engineering extinct genomes -- -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto -- -100 Yr, Anthropocene : the third industrial revolution ; iGEM -- -1 Yr, Holocene : from personal genomes to immortal human components -- Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: History - LC Classification (Downstairs)2012QH438.7 .C486 20121
  • Digital
    Julia Lynch.
    "A spectacular thirty-meter high viaduct spans the Ouseburn river as it makes its way through Newcastle-upon-Tyne, in the northeast corner of England. Modern, bright-yellow and black tram cars ply the viaduct, bringing passengers from working-class Byker to more affluent South Gosforth station in a journey that takes roughly ten minutes. But while the Byker viaduct allows riders to traverse the physical chasm carved out by the Ouseburn with ease, the social differences that separate residents of Byker from their better-off neighbors are much harder to bridge. Twice as many children in Byker (two in five) live in poverty as in Gosforth. And while a fifty-five-year-old man from Gosforth can expect to live another seventeen years in good health, the average fifty-five-year-old in Byker has only another nine years of healthy life expectancy ahead of him (Bambra 2016, 92)"-- Provided by publisher.
    Digital Access  Cambridge 2020
  • Print
    by Charles V. Morrill ...
    [v. 1] The upper extremity -- [v. 2] The neck and head -- [v. 3] The abdomen and pelvis -- [v. 4] The thorax and back.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.v. 2, 1945-.E535 .M871
  • Print
    Taylor, John Alexander.
    pt. 1. Head and neck -- pt. 2. Thoracic limb -- pt. 3. Pelvic limb -- pt. 4. Thorax and abdomen.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.v. 1-2, 1955-59.D1506 .T242
  • Digital
    Danilo Jankovic, Philip Peng, editors.
    This comprehensive atlas, which includes a wealth of illustrations and anatomic pictures created by the editors, covers a broad range of both regional anesthesia and pain intervention techniques, including neuromodulation. The book is unique in that it covers ultrasound and fluoroscopic-guided techniques, as well as traditional landmark-guided techniques. The authors and editors are internationally renowned experts, and share extensive theoretic and practical insights into regional anesthesia, pain therapy and anatomic sciences for everyday practice. The book addresses the application of ultrasound and fluoroscopic guidance for pain interventions and provides detailed coverage of ultrasound-guided and landmark-guided regional anesthesia. The book represents a detailed guide to the application of regional anesthesia and pain medicine; furthermore, examples of medico-legal documentation are also included in this edition. The 5th edition of Regional Nerve Blocks in Anesthesia and Pain Medicine is practically oriented and provides essential guidelines for the clinical application of regional anesthesia. It is intended for anesthesiologists and all professionals engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.
    Digital Access  Springer 2022
  • Digital
    Danilo Jankovic, Philip Peng.
    General Considerations -- Head and Neck Region -- Cervical Region -- Shoulder -- Upper extremity -- Elbow and Wrist -- Thoracic Region -- Lumbosacral spine -- Abdominal and Pelvic region -- Lower extremity block -- Lower extremity musculoskeletal injection -- Regional block for children.
    Digital Access  Springer 2015
  • Digital
    by Alexander Schmidt-Richberg.
    Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.
    Digital Access  Springer 2014
  • Digital
    prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Outcome Sciences, Inc., ; senior editors, Richard E. Gliklich, Nancy A. Dryer ; editor, Michelle B. Leavy.
    This User's Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure.
    Digital Access  
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    FulltextFulltext
    AddendumAddendum
  • Digital/Print
    Digital Access  Google Books 1964-
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.1964-F88 .U581
  • Digital
    by Ton J. Cleophas, Aeilko H. Zwinderman.
    This edition is a pretty complete textbook and tutorial for medical and health care students, as well as a recollection/update bench, and help desk for professionals. Novel approaches already applied in published clinical research will be addressed: matrix analyses, alpha spending, gate keeping, kriging, interval censored regressions, causality regressions, canonical regressions, quasi-likelihood regressions, novel non-parametric regressions. Each chapter can be studied as a stand-alone, and covers one field in the fast growing world of regression analyses. The authors, as professors in statistics and machine learning at European universities, are worried, that their students find regression-analyses harder than any other methodology in statistics. This is serious, because almost all of the novel methodologies in current data mining and data analysis include elements of regression-analysis. It is the main incentive for writing this 28 chapter edition, consistent of - 28 major fields of regression analysis, - their condensed maths, - their applications in medical and health research as published so far, - step by step analyses for self-assessment, - conclusion and reference sections. Traditional regression analysis is adequate for epidemiology, but lacks the precision required for clinical investigations. However, in the past two decades modern regression methods have proven to be much more precise. And so it is time, that a book described regression analyses for clinicians. The current edition is the first to do so. It is written for a non-mathematical readership. Self-assessment data-files are provided through Springer' s "Extras Online."
    Digital Access  Springer 2018
  • Digital
    Mario L. Rocci Jr., Stephen Lowes, editors.
    This book is intended to cover the fundamental and practical aspects of regulated bioanalysis. The editors are seeking leading scientists in the field to participate in the development of this book, which we envision as a "one of a kind" contribution to our field. The book is intended for students in the pharmaceutical sciences, chemistry, biology and related scientific disciplines interested in bioanalysis, as well as working scientists new to the field of regulated bioanalysis. It will also serve as a primer for those experienced in the field. The depth of the book will seek to give its audience a solid foundation of knowledge in regulated bioanalysis which can be leveraged further with "hands on" experience. Understanding that bioanalytical global regulations evolve, the book is not intended as a deep-dive into regulatory language nuances but rather to be an educational text on conducting defendable and auditable science to support modern bioanalysis. Following an introduction to the topic by the editors, the book then covers "non-scientific" aspects of the topic area including the regulations governing this work, logistical and operational aspects of running a regulated bioanalytical laboratory and appropriate laboratory documentation. Next a description of the typically encountered types of bioanalytical samples, analytes and their attributes is provided. This information then sets the stage for a detailed discussion of the analytical platforms and assay types used in the regulated bioanalysis of small and large molecules. Also provided is a discussion of the different analytical phases of the bioanalytical process (i.e. method development including various strategies, pre-study validation and sample analysis).
    Digital Access  Springer 2017
  • Digital
    edited by Avi Ashkenazi, Junying Yuan and James A. Wells.
    Examining the molecular mechanism of Bcl-2 family proteins at membranes by fluorescence spectroscopy -- Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry -- The structural biology of BH3-only proteins -- How to analyze mitochondrial morphology in healthy cells and apoptotic cells in Caenorhabditis elegans -- Apoptosis initiation through the cell-extrinsic pathway -- Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway -- Caspase enzymology and activation mechanisms -- Turning on caspases with genetics and small molecules -- A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases -- Measuring caspase activity in vivo -- Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology -- In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe -- Global analysis of cullular proteolysis by selective enzymatic labelling of protein N-termini -- Complementary methods for the indentification of substrates of proteolysis -- Phospholipid scrambling on the plasma membrane -- Studying apoptosis in the zebrafish.
    Digital Access  ScienceDirect 2014
  • Digital
    edited by Avi Ashkenazi, James A. Wells and Junying Yuan.
    Digital Access  ScienceDirect 2014
  • Digital
    David A. Dougan, editor.
    AAA+ proteolytic machines -- Machines of destruction: AAA+ proteases and the adaptors that control them / Eyal Gur, Ralf Ottofueling, David A. Dougan -- The Lon AAA+ protease / Eyal Gur -- FtsH protease-mediated regulation of various cellular functions / Takashi Okuno, Teru Ogura -- Regulatory proteolysis in bacteria -- General and regulatory proteolysis in Bacillus subtilis / Nöel Molière, Kürşad Turgay -- Proteolytic regulation of stress response pathways in Escherichia coli / Dimce Micevski, David A. Dougan -- Regulated proteolysis: control of the Escherichia coli [sigma]E-dependent cell envelope stress response / Sarah E. Barchinger, Sarah E. Ades -- Bacterial proteases and virulence / Dorte Frees, Lone Brøndsted, Hanne Ingmer -- Regulated proteolysis in yeast -- Roles of Cdc48 in regulated protein degradation in yeast / Alexander Buchberger -- The Role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control / Wolfgang Voos, Linda A. Ward, Kaye N. Truscott -- Ubiquitin-like protein modification and protein degradation in microorganisms -- The pup-proteasome system of mycobacterium tuberculosis / Marie I. Samanovic, Huilin Li, K. Heran Darwin -- Archaeal proteasomes and sampylation / Julie A. Maupin-Furlow.
    Digital Access  Springer 2013
  • Digital
    Weibin Zhang.
    For successful segregation of chromosomes during meiosis, chromosomes have to recognize and align with their correct homologous partners, and then stabilize the homologous alignment with assembly of a proteinaceous structure, called the synaptonemal complex (SC), between them. SC assembly is highly processive and cooperative, yet the SC structure does not distinguish between homologous and nonhomologous associations. Thus SC assembly has to be tightly regulated and coordinated with homologous pairing to ensure that the SC is stabilizing productive homologous associations. Moreover, homologous pairing is accompanied by dramatic chromosome movement and nuclear reorganization of chromosomes into a clustered configuration during C. elegans early meiotic prophase. Subsequently, the clustered chromosomes are redispersed into aligned homologs upon SC assembly. The exact mechanisms involved in regulation and coordination of homologous pairing and synapsis are poorly understood, and this thesis was aimed at gaining a better understanding of the coordination of these two inter-related meiotic events. We identified HAL-2 as a major player in this coordination. We demonstrated that HAL-2 promotes homologous pairing mainly by preventing detrimental effects of SC precursors (SYP proteins). Homologous pairing is not established in hal-2 mutants, and several markers indicative of pairing center-mediated chromosome movement are also absent in hal-2 mutants. Pairing centers (PCs) are cis-acting chromosomal sites that mediate chromosome movement by connecting chromosomes to cytoplasmic microtubules via the conserved SUN-1/ZYG-12 nuclear envelope-spanning complexes. hal-2 mutants also exhibit defective SC assembly, with SYP proteins being loaded inappropriately along single unpaired chromosomes in hal-2 mutants. Moreover markers of PC-mediated chromosome movement and function are coordinately restored in hal-2 mutants by the removal of SYP proteins. Combined with other data, these findings indicate that SYP proteins can inhibit homologous pairing and that HAL-2 promotes pairing largely by antagonizing this inhibition, thus allowing activation and regulation of PC function. Given that HAL-2 concentrates in the nucleoplasm of meiotic germ cells and colocalizes with SYP proteins in nuclear aggregates when SC assembly is prevented, we propose that HAL-2 functions to shepherd SYP proteins prior to licensing of SC assembly, preventing SC precursors from interacting inappropriately with chromosomes and allowing them to accumulate sufficiently for rapid cooperative assembly upon homology verification. In this thesis, we also identified and characterized me16, a hypomorphic allele of scc-3. SCC-3 is a conserved component of the cohesin complex, and the scc-3(me16) mutant was demonstrated to be a partial loss of function mutation by comparative analyses with a null mutant, scc-3(ku263). Besides reduced chromosomal localization of cohesin, scc-3(me16) mutants also display an extended region of clustered chromosomes, incomplete SC assembly and defective recombination. Further, analyses of nuclear aggregates that form in the scc-3(ku263) null mutants led to the findings that components of the lateral elements, including cohesin, colocalize into these nuclear aggregates and that this localization is not dependent on REC-8.
    Digital Access   2012
  • Digital
    Jose Rafael Morillo Prado.
    Many adult tissues with short-lived cells such as blood and skin require a constant replacement of aging cells. This process is often accomplished by adult stem cells, both self-renew and give rise to differentiating progeny. The process of self-renewal and differentiation must be tightly controlled: failure to self-renew results in the loss of the stem cell population, and lack of differentiation impairs tissue function with dire consequences to the organism. The fate decisions of stem cells are guided by the interaction between extracellular signals from the local microenvironment and intrinsic factors that set the state of the cell, many of which are coordinated by transcriptional programs that are, in turn, is controlled by posttranslational modifications of histones or replacement of canonical histones with histone variants. Polycomb group (PcG) proteins partake in the modification of histones and influence the transcriptional state of genes. PcG proteins are involved in transcriptional regulation by inducing the methylation and ubiquitination of histone tails, which maintain the repression of target genes through cell divisions. Emerging evidence indicates that replacement of canonical histones with histone variants is also important in cell fate decisions. Here I show that PcG proteins Psc and Su(z)2 restrict proliferation and maintain the identity of the cyst stem cell (CySC) lineage in the Drosophila testis. Loss of Psc and Su(z)2 gene function in CySC but not in the germline stem cell (GSC) lineage resulted in the formation of a tumor composed of proliferative mutant cells of abnormal identity, likely due to the derepression of the Hox gene Abdominal-B. The resulting formation of tumor-like masses of proliferative cells interfered non-cell autonomously with maintenance of the germline most likely by displacing GSCs from their niche. I also show that the histone variant His2Av is required cell-autonomously for maintenance of adult stem cells in both somatic and germ cell lineages. GSCs lacking His2Av function were lost over time. Surprisingly, GSCs null mutant for His2Av gave rise to germ cells that underwent normal transit amplification divisions and differentiation to spermatocytes and spermatids. Similarly, CySCs lacking His2Av were also lost over time, but were able to give rise to differentiated cyst cells. My results indicate that His2Av and Stat92E likely maintain GSCs and CySCs independently. His2Av mutant GSCs expressed Stat92E and had properly oriented centrosomes, while Stat92E mutant GSCs expressed His2Av. My results expand knowledge chromatin states required for adult stem cell function, showing, for the first time, that a histone variant has a unique role in maintaining stem cells.
    Digital Access   2012
  • Digital
    Alicia Roberta Shields.
    Adult stem cells generate short-lived but highly differentiated cells that maintain and repair tissues which exhibit high turnover rates or tissues prone to wear and tear including sperm, skin, blood, intestinal epithelium and muscle. Adult stem cells typically reside in specialized microenvironments or stem cell niches, and a major goal of stem cell biology is to understand how these specialized microenvironments regulate adult stem cell self-renewal, proliferation and differentiation to maintain tissue homeostasis. Drosophila spermatogenesis provides an in vivo model system to investigate how the niche governs adult stem cell behavior. At the apical tip of the Drosophila testis, a cluster of post-mitotic support cells called the hub maintains two adult stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Hub cells secrete the Unpaired ligand, which activates JAK-STAT signaling in the neighboring GSCs and CySCs. JAK-STAT signaling and coordinated crosstalk between the germ line and soma together maintain GSCs and CySCs within the stem cell niche and direct proper association between their differentiating daughter cells. In this dissertation, I address two questions: (1) how a putative gene target of JAK-STAT influences stem cell self-renewal and maintenance and (2) how a transcriptional co-activator controls stem cell differentiation. To investigate the mechanism by which JAK-STAT signaling regulates GSC maintenance, I probed the function of profilin, a regulator of filamentous actin (F-actin). Profilin had been identified as a STAT target gene in the testis stem cell niche by performing chromatin immunoprecipitation with antibodies against phosphorylated STAT (activated STAT), followed by high throughput sequencing (ChIP-Seq) (Davies et al., submitted). It was already known that profilin mutants lose early germ cells (Gönczy and DiNardo, 1996) but the germline stem cell phenotype had not been characterized. I showed that GSCs were lost throughout development with markedly reduced GSC numbers in testes from late third instar larval hypomorphs and strong loss-of-function profilin mutants. By performing clonal analysis with null profilin alleles, I found that wild-type function of profilin was required cell autonomously for GSC maintenance. GSCs homozygous mutant for profilin detached from the hub and differentiated. F-actin and Adenomatous Polyposis Coli 2 (APC2) localization at the hub-GSC interface was disrupted in testes from profilin mutants. Interestingly, germline specific over-expression of APC2 rescued GSC loss in profilin hypomorphs. My studies suggested that profilin may be indirectly required to stabilize APC2 and [beta]-catenin at E-cadherin-based adherens junctions between hub cells and GSCs. Intercellular conversations between the germ line and the soma regulate the behavior of the stem cells in both lineages. I showed that a mutation in the MED20 gene, which encodes one of the subunits of Mediator, a multiprotein complex that acts as an interface between gene-specific regulatory proteins and the general transcriptional machinery to stimulate transcription, resulted in over-proliferation of both germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Mediator function was required cell autonomously for CySCs to differentiate into somatic cyst cells, and non-autonomously for germ cell differentiation. This study reinforced the importance of crosstalk between stem cell lineages that work together to maintain tissue homeostasis.
    Digital Access   2012
  • Digital
    edited by Sajal Chakraborti, Naranjan S. Dhalla.
    Digital Access  Springer 2016
  • Digital
    Jie Xu.
    This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
    Digital Access  Springer 2020
  • Digital/Print
    Xiaojing Ma, editor.
    Regulation of IFN-[gamma] expression / John Fenimore, Howard A. Young -- The interleukin-1 family / Amir S. Yazdi, Kamran Ghoreschi -- Regulation of IL-4 expression in immunity and diseases / I-Cheng Ho, Shi-Chuen Miaw -- Regulation of IL-6 in immunity and diseases / Toshio Tanaka, Masashi Narazaki, Kazuya Masuda, Tadamitsu Kishimoto -- Regulation of interleukin-10 expression / Sascha Rutz, Wenjun Ouyang -- Regulation of interleukin-12 production in antigen-presenting cells / Hua Zheng, Yi Ban, Fang Wei, Xiaojing Ma -- Regulation of interleukin-17 production / Wenjuan Dong, Xiaojing Ma -- Regulation of interleukin-23 expression in health and disease / Iain Welsby, Stanislas Goriely -- Regulation and immune function of IL-27 / Qinghong Wang, Jianguo Liu -- The immunobiology of interleukin-35 and its regulation and gene expression / Mei Song, Xiaojing Ma.
    Digital Access  Springer 2016
  • Digital/Print
    Digital Access  Google Books 1972-
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.pt. 1, 1972.F261 .U581
  • Digital
    Jaclyn Geok Yueen Lim.
    Adult stem cells are undifferentiated cells that are capable of both self-renewal and differentiation into a variety of specialized cells. Adult stem cell lineages have been identified in several organs including skin, blood, breast, intestine, bladder, skeletal muscle, prostate, and the testes. The changes in homeostatic conditions in these organs caused by tissue turnover or injury rely heavily on the pool of adult stem cells for cell replenishment. Therefore, the activity of adult stem cells must be tightly controlled, and many of these regulations are orchestrated by the stem cell niche, the local microenvironment in which stem cells reside. The fast generation cycle and the genetic tractability of fruit flies make the Drosophila testis stem cell niche an ideal system for the study of adult stem cell regulation. The Drosophila testis maintains two types of stem cells: germline stem cells (GSCs) which give rise to sperm, and cyst stem cells (CySCs) which differentiate into cyst cells that encapsulate germ cells. The somatic cyst cell lineage has been implicated to be required at several stages of spermatogenesis and play pivotal roles in germline proliferation, survival, and differentiation. This dissertation focuses on understanding the role of the cyst cell lineage in GSC maintenance and investigating the mechanisms by which cyst cells direct early germ cell differentiation. Previously, it has been proposed that CySCs are the source of instructive self-renewal cues for GSCs. In contrast to this model, I showed that early germ cells with GSC characteristics can be maintained in the absence of CySCs and cyst cells. These germ cells failed to enter the transit-amplifying program, which is regarded as the first step of differentiation in many adult stem cell lineages. My observations suggest that cyst cells provide a pro-differentiation environment for GSCs, and that this mechanism(s) may be repressed in CySCs which indirectly allow for GSC self-renewal. Encapsulation of germ cells by cyst cells is one of the differentiation-promoting mechanisms imposed by the soma on the germline, and I have uncovered that this process requires activation of the EGFR-Ras-MEK-MAPK pathway in differentiated cyst cells. Furthermore, I also showed that repression of EGFR activation in CySCs is important in maintaining the population of GSCs and CySCs at the niche, as premature activation of the pathway resulted in displacement of GSCs from the hub by somatic cells. Preliminary studies revealed a STAT target gene, Socs36E as a negative regulator of the EGFR pathway in CySCs to prevent out-competition of GSCs by somatic cells. To understand how the somatic cyst cells germline differentiation, I performed two genetic screens: an RNAi screen of genes that caused premature germ cell differentiation when misexpressed in the soma, and a misexpression screen of genes predicted to be cell-surface and secreted proteins. Three promising candidates were identified through these screens: two ribosomal subunits, Rpl13A and RpS10a; and a septate junction component, Neurexin IV. The two ribosomal proteins may be involved in the soma to promote germ cell encapsulation. Neurexin IV however, operates non-cell autonomously in cyst cells to regulate germ cell differentiation into spermatocytes. Together, the results of this dissertation emphasize the importance and complexity of the interaction between adult stem cells and their microenvironment in maintaining tissue homeostasis.
    Digital Access   2013
  • Digital
    Yong Chun Chong.
    Hedgehog (Hh) signaling during embryogenesis and adult tissue homeostasis involves the activation of the oncoprotein Smoothened (Smo), but little is known about its mode of regulation. We attempt to identify proteins which regulate Smo function by performing a large-scale proteomic screen using Smo as the bait. We identify Dlg5 as a novel Smo-interacting protein whose association with Smo is triggered by Hh. Depletion of Dlg5 leads to global destabilization of Smo protein and concomitant reduced ciliary accumulation. We find that that Dlg5 localizes to the basal bodies in cultured cells, and our evidence further suggests that a Dlg5-scaffolded protein complex at the basal body is required to regulate Smo prior to Smo entry into the primary cilia.
    Digital Access   2014
  • Digital
    Rodney D. Geisert, Fuller W. Bazer, editors.
    Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics, along with the ability to selectively knockout genes of interest, have greatly advanced our understanding of the maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides the basis for new research endeavors to address infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. This book brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. The reviews provide readers with the latest knowledge on the role of the endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved in the regulation of conceptus development. .
    Digital Access  Springer 2015
  • Digital
    Dakang Xu, editor.
    "This book discusses recent research in innate immunity, which has revealed a large number of receptors that sense the presence of microorganisms or cellular damage in tissues. In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated. In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Previous data suggested that regulation of inflammasomes is mediated by microbes, but inflammasomes also have antimicrobial functions. Increasing evidence in mouse models, together with human data, strongly implicates an involvement of the inflammasome and uncontrolled inflammation in the initiation and progression of diseases with a high impact on public health. The book reviews novel aspects of functional genomics, epigenomics, transcriptomics, post-translational modifications, microbiome and immunometabolism in order to understand inflammatory signaling and responses, covering recent findings on the mechanisms underlying the regulation of inflammatory responses to pathogens, dysregulation of these responses in inflammatory disease, and the use of such mechanisms to boost or subdue the inflammatory response. Bridging the gaps in understanding between the fields of human and mouse immunology, it provides valuable insights into inflammatory-mediated disease and immune defense. Such innovative perspectives in both basic and clinical research promote the translation of knowledge to the clinic"--Publisher's description.
    Digital Access  Springer 2017
  • Digital
    Yanyin Kimberle Shen.
    The central nervous system, composed of the brain and the spinal cord, is made up of two broad classes of cell types: neurons and glia. The interaction between glial cells and neurons is crucial for proper development and function of the nervous system. The first type of glial cells, macroglia, includes astrocytes and oligodendrocytes. Oligodendrocytes are the cells that form myelin, an evolutionary adaptation that allows rapid and efficient propagation of action potentials along axons. Diseases of myelin include multiple sclerosis, in which damage to the myelin sheath in the central nervous system disrupts flow of information between the brain and the body, often leading to debilitating symptoms. The second glia cell type, microglia, performs a variety of roles in the CNS including phagocytic clearance of dead neurons and debris. Microglia have been implicated in neurodegenerative diseases such as Alzheimer's Disease, which is characterized by memory loss, neuronal death and accumulation of abnormal amyloid plaques. By understanding the pathways that control microglia and oligodendrocyte development and function, novel therapies for CNS diseases may be developed by harnessing the capabilities of these cell types. In this dissertation, I focus on the roles of the Rag-Ragulator complex and other lysosomal-associated proteins in microglia and oligodendrocytes. In Chapter 2, I describe the identification of mutations that disrupt the Rag-Ragulator complex in a screen for myelin mutants. In mutants lacking RagA and Lamtor4, components of the Rag-Ragulator complex, myelinated axons are reduced compared to wildtype siblings, despite the presence of oligodendrocytes. The absence of Rag-Ragulator function prevents oligodendrocytes from maturing and ensheathing exons. These results point toward a key function of lysosomes in myelination. In Chapter 3, I describe the microglial function of the Rag-Ragulator complex. RagA and Lamtor4 mutants have a reduced number of microglia. The few microglia that are present have an expanded lysosomal compartment - yet are unable to properly clear debris that they have engulfed. In Chapter 4, I characterize Tcirg1b mutants, which exhibit a similar microglia phenotype to RagA mutants. Tcirg1b encodes a component of the vacuolar proton pump that acidifies the lysosome. Tcirg1b mutants have microglia that are engorged with undigested apoptotic neuronal debris. Together, this work defines new roles of lysosomal genes in oligodendrocytes and microglia, thereby highlighting the importance of lysosome function in different glial cell types.
    Digital Access   2016
  • Digital
    Simona Rosu.
    Sexually reproducing organisms undergo meiotic recombination to increase genetic diversity and to ensure correct segregation of chromosomes at the first meiotic division. During meiotic recombination, DNA double-strand breaks (DSBs) are deliberately induced, and a subset of the breaks are repaired as inter-homolog crossovers (COs). Inter-homolog COs provide physical connections between homologous chromosomes that enable them to segregate away from each other. Despite reliance on COs for chromosome segregation, few COs are made per chromosome pair, implying mechanisms for robust CO control. In addition, DNA breaks are potentially dangerous lesions, therefore DSB formation and repair must be tightly regulated, both to ensure the formation of COs, but also to protect against deleterious effects. This thesis provides new insights into mechanisms that regulate DSB formation and repair, using the nematode Caenorhabditis elegans as a model organism. CO regulation mechanisms were probed by monitoring the repair outcome of a DSB induced at a defined site at different stages of meiotic progression, in WT and mutant situations. This analysis uncovered a previously unappreciated level of control in restricting CO number, which is to limit the duration of access to the homolog as a repair template. In addition, this work showed that when no competing breaks are present, a single induced DSB is converted to a CO with high efficiency. This feature helps achieve CO assurance. Insights into regulation of DSB formation were uncovered from the identification and characterization of novel protein DSB-2. DSB-2 is required for break formation, but is dispensable for later steps of meiotic recombination. DSB-2 localizes to chromatin during the time of break formation, suggesting it acts to promote competence for DSB formation. Both approaches presented in this thesis uncovered evidence for negative feedback regulatory mechanisms, suggesting a model wherein formation of CO-eligible recombination intermediates signals shutdown of DSB formation as well as shutdown of inter-homolog access. The proposed regulatory networks provide a mechanism to both ensure sufficient breaks and COs are made, and to shut down these processes to prevent deleterious effects as meiosis progresses.
    Digital Access   2012
  • Digital
    Sajal Chakraborti, Naranjan S. Dhalla, editors.
    Digital Access  Springer 2016
  • Digital/Print
    edited by Helge Grosshans.
    MicroRNA biogenesis and function : an overview / Rene F. Ketting -- Regulation of pri-miRNA processing through Smads / Akiko Hata and Brandi N. Davis -- Stimulation of pri-miR-18a processing by hnRNP A1 / Gracjan Michlewski, Sonia Guil, and Javier F. Cáceres -- KSRP promotes the maturation of a group of miRNA precursors / Michele Trabucchi ... [et al.] -- Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor / Sally Fujiyama-Nakamura, Kaoru Yamagata, and Shigeaki Kato -- Autoregulatory mechanisms controlling the microprocessor / Robinson Triboulet and Richard I. Gregory -- Regulation of pre-miRNA processing / Nicolas J. Lehrbach and Eric A. Miska -- The effect of RNA editing and ADARs on miRNA biogenesis and function / Bret S.E. Heale, Liam P. Keegan, and Mary A. O'Connell -- MiRNAs need a trim regulation of miRNA activity by trim-NHL proteins / F. Gregory Wulczyn ... [et al.] -- Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression / Nicole-Claudia Meisner and Witold Filipowicz -- Turnover of mature miRNAs and siRNAs in plants and algae / Heriberto Cerutti and Fadia Ibrahim -- MicroRNases and the regulated degradation of mature animal miRNAs / Helge Grosshans and Saibal Chatterjee.
    Digital Access  Springer 2011
  • Digital
    Nariyoshi Shinomiya, Hiroaki Kataoka, Qian Xie, editors.
    Digital Access  Springer 2018
  • Digital
    Christopher Paul Arnold.
    Stem cell self-renewal is dynamically regulated in response to extrinsic stimuli, but the intrinsic mechanisms that mediate the effects of these stimuli remain elusive. Emerging evidence suggests that miRNAs, an abundant class of ~22-nt small regulatory RNAs, play key roles in controlling the post-transcriptional genetic programs in stem and progenitor cells. We systematically examined miRNA expression profiles in various normal and aberrant adult tissue-specific stem and progenitor cells. Delineation of miRNAs whose expression correlated with changes in the self-renewal properties during normal development and as the result of mutant perturbations permitted the identification of miRNAs that marked stem to progenitor transition, termed SPT-miRNAs. Expression of SPT-miRNAs correlated with the exit from a self-renewing state as well as reduced self-renewal capacity in various normal and leukemia stem cells, suggesting that they may play a role in post-transcriptional gene silencing of key mediators of stem cell self-renewal. Consistent with this hypothesis, premature expression of a subset of these miRNAs could diminish the reconstitution potential of hematopoietic stem cells (HSCs) and the self-renewal of embryonic stem cells (ESCs). Furthermore, SPT-miRNAs targeted genes necessary for the self-renewal of HSCs, suggesting that up-regulation of these miRNAs permitted the efficient silencing of self-renewal programs during the stem to progenitor transition. Given the functional overlap of SPT-miRNAs in both embryonic and adult stem cells, we hypothesized that the expression of some SPT-miRNAs may be actively repressed by extrinsic signaling cues in stem cells at multiple developmental stages to potentiate their self-renewal. By subjecting ESCs to various culture conditions that diminished their self-renewal efficiency, we observed an up-regulation of a subset of SPT-miRNAs; in particular, members of the miR-181 family. Ectopic expression of this miRNA reduced ESC self-renewal whereas its deletion augmented ESC self-renewal in serum-free medium. These changes in self-renewal were attributable to simultaneous modulation of ESC proliferation and lineage commitment via target interactions with Lin28A, Spry4, and Dusp6. Finally, we found that the BMP-signaling pathway, necessary for the efficient self-renewal of ESCs, played a key role in the suppression of miR-181a. Collectively, these results reveal how extrinsic signaling cues mediate the quantitative post-transcriptional regulation of stem cell self-renewal programs via the modulation of miRNAs. Our study demonstrated one approach to identify and investigate the role of intrinsic regulators and provided novel insight into how to uncover the intrinsic regulators of stem cell self-renewal with implications on manipulation of stem cell expansion ex vivo.
    Digital Access   2012
  • Digital
    Anshul Rana.
    Store-operated calcium entry (SOCE) is a key calcium signaling pathway present in most cell types. The pathway is activated in response to signaling events, such as the activation of phospholipase C coupled receptors on the plasma membrane, that deplete the endoplasmic reticulum (ER) Ca2+-stores. Depletion of these stores is sensed by the STIM proteins, STIM1 and STIM2, residing on the ER membrane. Upon store-depletion, the dissociation of Ca2+ from their luminal domains triggers conformational changes in STIM proteins and leads to their accumulation at regions of close apposition of the ER and plasma membrane (PM). At these ER-PM junctions, STIMs directly bind and activate Orai calcium channels in the plasma membrane, leading to an influx of Ca2+. While STIM1 is thought to respond to higher levels of store-depletion and mediate responses to receptor signaling, STIM2 can be activated by even mild store-depletion and is thought to play a role in maintaining Ca2+ homeostasis. Ca2+ signaling through SOCE regulates several downstream responses such as transcriptional regulation, secretion, and cellular motility. Perturbations in SOCE are linked with defects in a number of tissue types, including defects in immune function, muscle development and function, platelet activation, skin homeostasis among others. The amplitude and dynamics of SOCE are important determinants of Ca2+ dependent downstream responses, and thus critical to maintaining these physiological functions. However, while the basic mechanism of SOCE activation by STIM-Orai coupling is well understood, mechanisms that modulate the amplitude and dynamics of SOCE are less clear. In recent years, a number of such modulatory mechanisms have been proposed, including transcriptional regulation of STIM proteins, post-translational modifications, and the binding of accessory proteins. These mechanisms produce quantitative changes in the activity of STIM proteins, but without altering their fundamental role as activators of Orai channels. A largely unexplored mechanism with the potential to qualitatively alter STIM function is alternative splicing. Both STIM1 and STIM2 are multi-exonal proteins, and hence are expected to form multiple splice isoforms. However, the alternative splicing of STIM proteins and its role in the regulation of SOCE has not been fully explored so far. In this thesis, I explore the role of a novel STIM2 splice isoform, named STIM2 [beta] (the conventional isoform being referred to as STIM2 [alpha]), in regulating SOCE. STIM2 [beta] is formed by the in-frame splicing of exon 9 of the STIM2 genomic locus. This splicing event leads to the insertion of 8-amino acids, referred to as the 2 [beta] insert, in the middle of STIM2's key Orai binding domain. In contrast to all known STIM isoforms, STIM2 [beta] was found to inhibit SOCE mediated by Orai1 channels. In addition, STIM2 [beta] acts as a negative regulator of cytosolic and ER Ca2+ levels. These functional changes suggest that the alternative splicing qualitatively changes STIM2 function and converts it from an activator to an inhibitor of SOCE. Analysis of STIM2 [beta] function, using FRET and puncta formation assays, revealed that the 2 [beta] insert disrupts STIM2 [beta] binding to Orai1. However, STIM2 [beta] maintains the ability to heterodimerize with STIM2 [alpha] and STIM1, and is tethered to Orai channels as part of these heterodimers. Mutations in the 2 [beta] insert were found to significantly reduce the ability of STIM2 [beta] to inhibit SOCE, indicating that the 2[beta] insert sequence plays a crucial role in the inhibitory mechanism. Analysis of STIM2 [beta] mutants and Orai1-STIM2 [beta] chimeras suggested that STIM2 [beta] actively inhibits Orai1 channels through a sequence-specific interaction. STIM2 [beta] thus functions as a store-operated inhibitor of Orai1 channels. These findings reveal a novel modulatory mechanism for modulating the amplitudes and dynamics of SOCE by regulating STIM2 splicing. The thesis begins with an introductory chapter discussing the function and key mechanistic aspects of Ca2+ signaling and SOCE. Chapter 2 describes the discovery and mechanistic studies of STIM2 [beta]. Chapter 3 provides a discussion of some of the key remaining questions regarding the regulation of SOCE by STIM2 [beta] and also describes some experimental approaches to answer them.
    Digital Access   2015
  • Digital
    Gerald Ming Jie Liew.
    Primary cilia organize cellular signaling cascades by dynamically concentrating signaling receptors in response to extracellular cues. In particular, the removal of signaling molecules from cilia tunes the sensitivity of major signaling pathways but remains a poorly understood process. A major sorting complex for the cilium is the BBSome, a coat-like complex of eight Bardet-Biedl Syndrome (BBS) proteins, which directly recognizes signal receptors and co-moves with the intraflagellar transport (IFT) machinery within cilia. Importantly, recruitment of the BBSome to membranes relies on GTP loading onto the ARF-like GTPase ARL6/BBS3, but no regulators for the nucleotide state of ARL6 have been identified so far. Identification of the guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP) for ARL6 is key to pinpointing the locations where BBSome coats assemble and disassemble, respectively, and will further shed light on the pathomechanisms of BBS. Because mutations in the Rab-like GTPase and IFT-B subunit IFT27/RABL4 were recently identified in a BBS family, we sought to characterize the function of IFT27 in BBSome-mediated trafficking. Strikingly, ARL6, BBSome and the candidate BBSome cargo GPR161 accumulated in IFT27-deficient cilia, and photokinetic assays on stable cell lines expressing fluorescently tagged BBSome revealed that IFT27 perturbation reduces BBSome exit rates ~3-fold while leaving BBSome entry rates unaffected. At the molecular level, IFT27 disengages from the rest of IFT-B to directly associate with and stabilize the nucleotide-free form of ARL6 against aggregation. Thus, we propose that within cilia, IFT27 dissociates from IFT-B to directly participate in GTP loading onto ARL6, promoting the assembly of exit-bound and cargo-laden BBSome coats. Additional mechanisms for the regulation of IFT27 and ARL6 within cilia are discussed.
    Digital Access   2016
  • Digital/Print
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2000
  • Digital/Print
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2001
  • Digital/Print
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2001
  • Digital/Print
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2001
  • Digital/Print
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2006
  • Digital/Print
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Digital Access  ScienceDirect 2006
  • Digital/Print
    edited by David P. Siderovski.
    Digital Access  
    ProviderVersion
    ScienceDirectpt. A
    ScienceDirectpt. B
  • Digital/Print
    Evelyn Walter, editor.
    This book provides an up to date user friendly resource on the emerging field of digital medicine and its present and potential future role in modern healthcare. Chapters are written by a specialist on each area in an easy to read format, which broadly covers the potential of digital medicine in epidemiology, precision medicine and surgery. Chapters focus on aspects of telemedicine, the applications of big data, artificial intelligence, blockchain, regenerative medicine, legal aspects and business models. Furthermore, guidance is given on medical ethics and how to manage doctor patient relationships in the modern age. Digital Medicine comprehensively reviews the emerging field of digital medicine in modern healthcare and is therefore a critical resource for physicians and medical trainees who are looking for comprehensive resource on digital medicine and its potential role in modern healthcare.
    Digital Access  Springer 2019
  • Digital/Print
    Maria Cristina Galli, Mercedes Serabian, editors.
    United States Food and Drug Administration Regulation of Gene and Cell Therapies -- The National Institutes of Health Oversight of Human Gene Transfer Research: Enhancing Science and Safety -- Regulatory Oversight of Cell and Gene Therapy Products in Canada -- Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products -- Regulation of Clinical Trials with Advanced Therapy Medicinal Products in Germany -- Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective -- Requirements for Clinical Trials with Gene Therapy and Transplant Products in Switzerland -- Regulatory Frameworks for Gene and Cell Therapies in Japan -- Regulatory Oversight of Gene Therapy and Cell Therapy -- Regulation of Cell and Gene Therapy Medicinal Products in Taiwan -- Regulatory Oversight of Cell- and Tissue-Based Therapeutic Products and Gene Therapy Products in Singapore -- The Regulatory Pathway for Advanced Cell Therapy and Gene Therapy Products in Brazil: A Road to Be Built -- Index.
    Digital Access  Springer 2015
  • Digital
    edited by Gaetano Vitale and Francesca Mion, Department of Medical and Biological Sciences, University of Udine, Udine, Italy.
    Digital Access  Springer 2014
  • Digital
    Vinagolu K. Rajasekhar, Mohan C. Vemuri, editors.
    Digital Access  Springer 2009
  • Digital
    edited by Gordon G. Carmichael.
    Diverse functions and mechanisms of mammalian long noncoding RNAs -- Sequence-defined oligoaminoamides for the delivery of siRNAs -- A biochemical approach to identify direct microRNA targets -- Native gel analysis for mammalian microRNPs assembled from pre-microRNAs -- Identification and validation of miRNA target sites within nontraditional miRNA targets -- Fractionation of non-polyadenylated and ribosomal-free RNAs from mammalian cells -- Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells -- RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins -- nRIP-seq: A technique to identify RNA targets of an RNA binding protein on a genome-wide scale -- Analysis of the subcellular distribution of RNA by fluorescence in situ hybridization -- RNA fluorescence in situ hybridization in cultured mammalian cells -- Locating RNAs in situ with FISH-STIC probes -- Rapid and efficient elimination of specific nuclear noncoding RNAs in mammalian cells with antisense oligonucleotides -- On using magnesium and potassium ions in RNA experiments -- Studying the affinity, kinetic stability, and specificity of RNA/protein interactions: SINE ncRNA/Pol II complexes as a model system
    Digital Access  Springer 2014
  • Digital
    Bibekanand Mallick, Zhumur Ghosh, editors.
    pt. 1. Basics -- pt. 2. Methods -- pt. 3. Applications.
    Digital Access  Springer 2012
  • Digital
    Wolfgang R. Hess, Anita Marchfelder.
    This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.
    Digital Access  Springer 2012
  • Digital
    Shuiping Jiang, editor.
    Digital Access  Springer 2008
  • Digital
    edited by Franz-Xaver Reichl, Michael Schwenk.
    This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.
    Digital Access  Springer 2019
  • Digital
    Kimberly A. Sackheim, editor.
    "Designed in a concise, easy-to-read style for a wide variety of medical occupations, the Rehab Clinical Pocket Guide is the ideal, handy reference for rehabilitation professionals and other health providers. Divided into four sections that cover inpatient care, clinical strategies, outpatient care, and additional diagnostics and therapeutics, this is the first book of its kind to contain all of the relevant clinical information needed on the rehabilitation unit, including specific admission order sets and topics such as medication dosing, consultant recommendations, specific rehabilitation goals and treatments, and even billing details for various diagnoses. The Rehab Clinical Pocket Guide offers all the clinical material needed to properly treat patients and excel in the field of physical medicine and rehabilitation and will prove an indispensable resource for medical students, residents, physicians, therapists and nutritionists."--P. 4 of cover."
    Digital Access  Springer 2013
  • Digital
    Maurizio Lopresti, Lorenzo Panella, editors.
    Based on ten years of experience, this book provides a valuable tool for professionals in the field of bone tumors. Although rare, when diagnosed these tumors can cause anxiety and apprehension in patients, and it is necessary to find rapid solutions and medical rehabilitation protocols capable of dealing with these delicate cases. As such those working in this field need to constantly update their knowledge to ensure an appropriate approach to this particular pathology. This book is a useful consultation tool for physiotherapists, orthopedic oncology surgeons, rehabilitation specialists and everyone who works with bone tumors on a regular basis.
    Digital Access  Springer 2021
  • Print
    Eugene J Taylor, editor.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.1960-M701 .I61 19601
  • Digital
    A.B. Imhoff [and 4 others], eds.
    Digital Access  Springer 2016
  • Digital
    Paolo Capodaglio, editor.
    This book has a unique focus on physiotherapy techniques and training methods that are ideally suited for the obese patient. Despite its related comorbidities and disability, not to mention its pandemic proportions, the impact of obesity on individual capacities and rehabilitative outcomes is often neglected by physiotherapists and physical trainers alike. The number of disabled subjects who are also obese is now increasing worldwide, as is the rate of obese patients admitted to post-acute rehabilitation units. The effective rehabilitative treatment of these patients involves special multidisciplinary considerations. This book fills that gap, by gathering evidence-based chapters addressing not only the physiological limitations of obese subjects but also state-of-the-art, novel and specific treatment and training modalities suited for these patients. Though the content is primarily intended for rehabilitation practitioners (physiotherapists, nutritionists, dieticians, psychologists, PRM specialists), it will also benefit students and researchers engaged in this particular multidisciplinary field. The book's ultimate goal is to increase professionals' awareness of this multidisciplinary area, and to provide a pragmatic guidebook for those who want to engage in the rehabilitation of patients who are also obese.
    Digital Access  Springer 2020
  • Digital
    Giuseppe Verde.
    This book explores rehabilitation methodology in Evidence Based Medicine (EBM), providing a description of the main traditional strategies used by physiotherapists. It supplies both physiotherapists and students with updated information on scientific professional choices for the patient's benefit by collecting traditional knowledge and trying to answer a fundamental question: is there an objective way of rehabilitating patients by using traditional concepts at the light of new evidences? Every physiotherapist experiences the need of updating his knowledge and professional actions. Research can help but personal experience remains fundamental for clinical reasoning. The book examines rehabilitation strategies, main rehabilitation techniques, as well as scientific practice and suggestions stemming from research. The various rehabilitation strategies and techniques converge in the daily work becoming the basis for operative choices finalized to solve the patient's needs. Methodology characterizes the work of a physiotherapist who should take care of his scientific education by means of effective teaching plans, educational rules and ethic professional code. This book will be a useful tool for physiotherapy students but also for professionals.
    Digital Access  Springer 2022
  • Digital
    Terri M. Skirven [and five others]
    Digital Access  ClinicalKey v. 1-2, 2020
  • Digital
    Craig Liebenson, DC, editor.
    Presents a practical overview of spinal rehabilitation combining McKenzie, Janda, Contract-Relax and Stabilization approaches into one common treatment protocol.
    Digital Access  Ovid 2020
  • Digital
    by Emma K. Stokes.
    Outcome measurement and practice -- International classification of functioning, disability and health (ICF) -- How to choose an outcome measure -- Reliability : error in measurement -- Validity -- Measuring change -- Measuring mobility -- Measuring physical activity -- Measuring fatigue -- Measuring neurological conditions and rehabilitation -- Evaluating satisfaction.
    Digital Access  ScienceDirect 2010
  • Digital
    Mieczyslaw Pokorski, editor.
    "The focus of this book lies on novel aspects of rehabilitation medicine used as a treatment tool in both physical and mental spheres. The articles cover a diverse spectrum, such as rehabilitation in orthopedic pathologies, the exemplary of which is knee joint degeneration, in perioperative metastatic cancer diseases, or in neural degeneration requiring a transplant of donor nerve fibers into the defunct nerve. Advanced research studies involving proprioceptive neuromuscular facilitation, photobiomodulation, or yoga meditative techniques to regain functional ability are dealt with. The topic is expanded by a comprehensive picture of chosen molecular, genetically underpinned, diagnostics in hepatitis C infections and of novel ideas in drug design holding a curative promise in central neurodegeneration, such as development of brain-blood-barrier permeable oleic derivatives of the hydrophilic dopamine compound. The emerging rehabilitative modes and applications are posed to influence future health care delivery. The state-of-the art research is addressed to scientists, clinicians, therapists, and allied health care professionals"--Publisher's description.
    Digital Access  Springer 2018
  • Digital
    Wenru Zhao.
    Digital Access  Springer 2019
  • Digital
    Andrew I. Elkwood, Matthew Kaufman, Lisa F. Schneider, editors.
    Digital Access  Springer 2017
  • Digital
    [edited by] Eric F. Reichman.
  • Digital
    Howard J. Ross.
    Diversity in business and other organizations has been a goal for more than a quarter of a century, yet companies struggle to create an inclusive work place. In Reinventing Diversity, one of America's leading diversity experts explains why most diversity programs fail and how we can make them work. In this inspiring guide, Howard Ross, uses interviews, personal stories, statistics, and case studies to show that there is no quick fix, no easy answer. Acceptance needs to become part of the culture ofa company, not just a mandated attitude. People still feel alienated because of their race, langu.
    Digital Access  ProQuest Ebook Central 2011
    Limited to 3 simultaneous users
  • Digital
    Luciano L'Abate, Mario Cusinato, Eleonora Maino, Walter Colesso, Claudia Scilletta.
    Relational competence the set of traits that allow people to interact with each other effectively enjoys a long history of being recorded, studied, and analyzed. Accordingly, Relational Competence Theory (RCT) complements theories that treat individuals' personality and functioning individually by placing the individual into full family and social context. The ambitious volume Relational Competence Theory: Research and Mental Health Applications opens out the RCT literature with emphasis on its applicability to interventions, and updates the state of research on RCT, examining what is robust and verifiable both in the lab and the clinic. The authors begin with the conceptual and empirical bases for the theory, and sixteen models demonstrate the range of RCT concerns and their clinical relevance, including: socialization settings for relational competence, the ability to control and regulate the self, relationship styles, intimacy and negotiation, the use of practice exercises in prevention and treatment of pathology, appendices featuring the Relational Answers Questionnaire and other helpful tools. Relational Competence Theory both challenges and confirms much of what we know about the range of human relationships, and is important reading for researchers, scholars, and students in personality and social psychology, psychotherapy, and couple and family counseling.
    Digital Access  Springer 2010
  • Digital/Print
    Office of Applied Studies.
    Digital Access  Google Books 1999
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Stored offsite. Please request print.1999RJ506.D78 .R45 19991
  • Digital
    Jeffrey A. Kottler, Richard S. Balkin.
    Digital Access  Wiley 2017
  • Digital
    Stephen Seligman.
    Acknowledgments -- How we got here : a roadmap to psychoanalytic theories of childhood and development -- Childhood has meaning of its own : freud and the invention of psychoanalysis -- A. freud's legacy for developmental psychoanalysis: childhood at the origins -- B. real women and children : the emergence of child psychoanalysis -- Theory i: foreshadowings : core themes and controversies in the early freudian theories -- The baby at the crossroads : the structural model, ego psychology, and object relations theories -- A. ego psychology : psychic structure, adaptation, and external realities -- B. kleinian psychoanalysis : internal objects, phantasies, and the centrality of the infantile primitive mind -- The middle group : toward a relationship-based theory of psychic realities and environments -- Theory ii: what is a "robust developmental perspective?" -- The postwar diversification and pluralization of psychoanalysis in the united states: interdisciplinary expansion, the widening clinical scope and the new developmentalism -- The relational baby : intersubjectivity and infant development -- Infancy research : toward a relational-developmental psychoanalysis -- Clinical implications of infancy research : affect, interaction and non-verbal meaning in the dyadic field -- Theory iii: the relational baby : psychoanalytic theory and technique -- Continuities from infancy to adulthood : the baby is out of the bathwater -- Theory iv: the move to the maternal : gender, sexualities, and the oedipus complex in light of intersubjective developmental research -- Attachment and recognition in clinical process : reflection, regulation and emotional security -- Intersubjectivity today : the orientation and concept -- Attachment theory and research in context : clinical implications -- Recognition and mentalization in infancy and psychotherap y: convergences of attachment theory and psychoanalysis -- Mentalization and metaphor, acknowledgement and grief : forms of transformation in the reflective space -- Infant-parent interactions, phantasies, and an "internal two-person psychology" : projective identification and the intergenerational transmission of early trauma in kleinian theory and intersubjective infant research -- Vitality, activity, and communication in development and psychotherapy -- Coming to life in time : temporality, early deprivation, and the sense of a lively future -- Forms of vitality and other integrations : daniel stern's contribution to the psychoanalytic core -- Awareness, confusion and uncertainty : nonlinear dynamics in everyday practice -- Feeling puzzled while paying attention : the analytic mindset as an agent of therapeutic change -- Dynamic systems theories as a basic framework for psychoanalysis : change processes in development and therapeutic action -- Searching for core principles : louis sander's synthesis of biological, psychological, and relational factors and contemporary developmental psychodynamics.
    Digital Access  TandFonline 2018
  • Digital
    A. Ravishankar Rao, Guillermo A. Cecchi, editors.
    Introduction -- Adaptation and contraction theory for the synchronization of complex neural networks -- Temporal coding is not only about cooperation, it is also about competition -- Using non-oscillatory dynamics to disambiguate pattern mixtures -- Functional constraints on network topology via generalized sparse -- Evolution of time in neural networks, from the present to the past, and forward to the future -- Synchronization of coupled pulse-type hardware neuron models for CPG model -- A univesal abstract-time platform for real-time neural networks -- Solving complex control tasks via simple rule(s), using chaotic dynamics in a recurrent neural network model -- Time scale analysis of neuronal ensemble data used to feed neural network models -- Simultaneous EEG-fMRI, integrating spatial and temporal resolution -- Erratum to: Time scale analysis of neuronal ensemble data used to feed neural network models.
    Digital Access  Springer 2012
  • Digital
    editors, Bernard F. Morrey, Matthew C. Morrey
    "Part of the highly regarded Master Techniques in Orthopaedic Surgery series, Relevant Surgical Exposures, Second Edition, is a concise, lavishly illustrated reference designed to assist today's orthopaedic surgeons in a crucial task: choosing and executing the exposure necessary for a given procedure. It presents successful, widely used exposures for hand and wrist, forearm, elbow, humerus, shoulder, pelvis, hip and acetabulum, femur, knee, tibia and fibula, foot and ankle, and spine, all in step-by-step detail. Fully revised with new exposures and new illustrations throughout, this Second Edition is ideal for orthopaedic surgeons at all levels of experience.-Presents approximately 100 preferred exposure techniques of surgical masters, illustrated with full-color, sequential, surgeon's-eye view photographs, as well as superb drawings by noted medical illustrators.-Includes substantial additions to the shoulder, hip and acetabulum, and knee, as well as many more exposures for minimally invasive procedures in all areas.-Enhanced features and additional drawings throughout.-Provides the up-to-date guidance you need to master both well-established exposures and recent exposures for minimally invasive procedures.-Contains practical guidance, pearls, and tips from Dr. Bernard Morrey and his son, Dr. Matthew Morrey, as well as other leading orthopaedic surgeons. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! -Read directly on your preferred device(s), such as computer, tablet, or smartphone-Easily convert to audiobook, powering your content with natural language text-to-speech-Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"--Provided by publisher
    Digital Access  LWW Health Library 2019
  • Digital
    edited by Harold G. Koenig.
    Religion and Mental Health: Research and Clinical Applications summarizes research on how religion may help people better cope or exacerbate their stress, covering its relationship to depression, anxiety, suicide, substance abuse, well-being, happiness, life satisfaction, optimism, generosity, gratitude and meaning and purpose in life. The book looks across religions and specific faiths, as well as to spirituality for those who don't ascribe to a specific religion. It integrates research findings with best practices for treating mental health disorders for religious clients, also covering religious beliefs and practices as part of therapy to treat depression and posttraumatic stress disorder.
    Digital Access  ScienceDirect 2018
  • Digital
    Adina Kalet, Calvin L. Chou, editors.
    Defining and Assessing Competence -- An Example of a Remediation Program -- 'She Needs to Read More': Helping trainees who struggle with medical knowledge -- Remediation of Interpersonal and Communication Skills -- Remediation of Physical Exam Skills -- Assessing and Remediating Clinical Reasoning -- Remediating Lapses in Professionalism -- 'You said, I heard': Speaking the subtext in interracial conversations -- Learning Differences and Medical Education -- 'Well, This Is Awkward': Autism Spectrum Disorder in Medical Trainees -- Stress and Distress and Wellness -- Perspectives from a Psychiatrist in an Office of Advising Resources -- The Metacognitive Competency: The key to life-long learning -- Use of Reflection as a Remediation Tool -- Feedback -- Appreciative Coaching: A positive process for remediation -- Preparing Program Directors to Address Unprofessional Behavior -- The View from the Dean's Office -- Preparing to Conduct Remediation -- 'The Prognosis is Poor': When to give up -- A Research Agenda for the Field of Remediation -- Epilogue: A Student's Perspective on Remediation.
    Digital Access  Springer 2014
  • Digital/Print
    edited by Zena Sharman.
    "To remedy means to heal, to cure, to set right, to make reparations. The Remedy invites writers and readers to imagine what we need to create healthy, resilient, and thriving LGBTQ communities. This anthology is a diverse collection of real-life stories from queer and trans people on their own health-care experiences and challenges, from gay men living with HIV who remember the systemic resistance to their health-care needs, to a lesbian couple dealing with the experience of cancer, to young trans people who struggle to find health-care providers who treat them with dignity and respect. The book also includes essays by health-care providers, activists, and leaders, with something to say about the challenges, politics, and opportunities surrounding LGBTQ health issues. Both exceptionally moving and an incendiary call-to-arms, The Remedy is a must-read for anyone--gay, straight, trans, and otherwise--passionately concerned about the right to proper health care for all. Contributors include Amber Dawn, Sinclair Sexsmith, Francisco Ibanez-Carrasco, Cooper Lee Bombardier, Kara Sievewright, Kelli Dunham, and many more."-- Provided by publisher.
    Digital Access  ProQuest Ebook Central 2016
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2016RA564.9.H65 R44 20161
  • Digital/Print
    [edited by] Christopher B. Wilson, Victor Nizet, Yvonne A. Maldonado, Jack S. Remington, Jerome O. Klein.
    Digital Access  ClinicalKey 2016
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2016RJ275 .I54 20161
  • Digital
    authors, Jonathan S. Steinberg, Niraj Varma
    Digital Access  Ovid 2020
  • Digital
    editors, Claudio Ronco, Carlo Crepaldi, Mitchell H. Rosner.
    Digital Access  Karger 2019
  • Digital
    Maulin P Shah, editor.
    The abundance of organic pollutants found in wastewater affect urban surface waters. Traditional wastewater management technologies focus on the removal of suspended solids, nutrients and bacteria, however, new pollutants such as synthetic or naturally occurring chemicals are often not monitored in the environment despite having the potential to enter the environment and cause adverse ecological and human health effects. Collectively referred to as "emerging contaminants," they are mostly derived from domestic activities and occur in trace concentrations ranging from pico to micrograms per liter. Environmental contaminants are resistant to conventional wastewater treatment processes and most of them remain unaffected, causing contamination of receiving water. This in turn leads to the need for advanced wastewater treatment processes capable of removing environmental contaminants to ensure safe fresh water sources. This book provides an up-to-date overview of the current bioremediation strategies, including their limitations, challenges and their potential application to remove environmental pollutants. It also introduces the latest trends and advances in environmental bioremediation, and presents the state-of-the-art in biological and chemical wastewater treatment processes. As such, it will appeal to researchers and policy-makers, as well as undergraduate and graduate environmental sciences students
    Digital Access  Springer 2021
  • Digital
    [edited by] Robert W. Schrier.
    "Geared to residents and fellows in nephrology, internal medicine, and other specialties, Renal and Electrolyte Disorders bridges the gap between basic and clinical sciences for the many disorders associated with electrolyte imbalances and kidney dysfunction. This edition has been thoroughly revised by worldrenowned contributors to reflect recent developments in renal pathophysiology"--Provided by publisher.
    Digital Access  Ovid 2018
  • Digital
    John A. Libertino, editor.
    Epidemiology, Screening, and Clinical Staging / Michael J. Lipsky, Christopher M. Deibert -- Molecular Biology and Genetics / Jeff Klomp, Karl Dykema, Bin Tean Teh, Kyle Furge -- Familial and Hereditary Syndromes / Brian Shuch, Peter Pinto -- Pathology of Renal Cell Carcinoma / Fang-Ming Deng, Jonathan Melamed, Ming Zhou -- Imaging of Renal Cancer / Jalil Afnan, Christoph Wald -- Molecular Imaging for Renal Cell Carcinoma / Jian Q. Yu, Yamin Dou -- History of Renal Surgery for Cancer / Kamal Nagpal, Karim Hamawy -- Natural History, Role of Biopsy, and Active Surveillance of Renal Masses / Anthony T. Corcoran, Marc C. Smaldone, Robert G. Uzzo -- Interventional Radiology and Angioinfarction: Transcatheter Embolization of Renal Tumors / Sebastian Flacke, Shams Iqbal -- Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma / Patrick A. Kenney, Christopher G. Wood -- Rationale for Partial Nephrectomy / Nicholas Donin, William Huang -- Objectifying Complexity of Kidney Cancers: Relationships of Tumor Anatomy and Outcomes / Serge Ginzburg, Alexander Kutikov, Robert G. Uzzo -- Open Partial Nephrectomy / Patrick A. Kenney, Matthew F. Wszolek, John A. Libertino -- Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses / Casey G. Kowalik, David Canes, Ali Moinzadeh -- Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava / Chad Wotkowicz, John A. Libertino -- Role of Lymphadenectomy / Prof. Dr. Hein Van Poppel -- Postoperative Surveillance Protocols for Renal Cell Carcinoma / Megan M. Merrill., Jose A. Karam -- Role of Surgery in Locally Recurrent and Metastatic Renal Cancer / Paul Russo -- Outcomes: Prognostic Factors, Models, and Algorithms / Brandon K. Isariyawongse, Michael W. Kattan -- Adjuvant Systemic Therapy, Immunotherapy, and Targeted Treatment / Linda Cerbone, Cora N. Sternberg -- Role for Radiation Therapy in Renal Cancer / Andrea McKee, Arul Mahadevan, Timothy Walsh -- Surgical Management for Transitional Cell Carcinoma of the Upper Tract / Jason R. Gee -- Management of Non-clear Cell Renal Cell Carcinoma / Henry J. Conter, Jose A. Karam, Nizar M. Tannir.
    Digital Access  Springer 2013
  • Digital
    John A. Libertino, Jason R. Gee, editor.
    This fully updated second edition provides a comprehensive, state-of-the-art review of renal cancer, and will serve as a guide for urology residents, clinicians, surgeons, and researchers with an interest in renal cell carcinoma. The title reviews the latest information regarding epidemiology, clinical staging, molecular biology and genetics, hereditary syndromes, pathology, imaging, molecular imaging, interventional radiology, surgical advances, and the unified approach to surgery and systemic therapy of renal cell carcinoma. It also addresses the management of localized RCC, locally advanced disease, and advanced disease. A valuable resource for physicians and researchers dealing with renal cancer, Renal Cancer: Contemporary Management, Second Edition provides a comprehensive summary of the field that will guide patient management and stimulate further clinical and basic science research efforts.
    Digital Access  Springer 2020
  • Digital
    Christopher Anderson, Mehran Afshar, editors.
    Renal Cancer: Current Status and Innovations provides a useful guide to the fundamental basics and latest diagnostic and treatment techniques for Renal Cancer. It features clearly structured and easy-to-understand chapters enabling the reader to develop a thorough understanding of screening, surveillance, diagnostics, pathology, robotic and open surgical approaches, ablation, medical treatment, psychology, and future innovations. The book provides a valuable resource for the full spectrum of clinicians involved in the multidisciplinary management of Renal Cancer.
    Digital Access  Springer 2022
  • Digital
    Jean J.M.C.H. de la Rosette, Cora N. Sternberg, and Hein P.A. van Poppel (eds.).
    Digital Access  Springer 2008
  • Digital
    Steven C. Campbell, Brian I. Rini, editors.
    Part 1. Localized Disease -- Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors / Frédéric D. Birkhäuser, Nils Kroeger and Allan J. Pantuck -- Pathology of Renal Cell Carcinoma / Ming Zhou and Huiying He -- Familial Renal Cell Carcinoma / Simon P. Kim and Bradley C. Leibovich -- Imaging of Renal Cell Carcinoma / Andrei S. Purysko, Erick M. Remer and Brian R. Herts -- Prognostic Factors for Localized Renal Cell Carcinoma / Brian R. Lane -- Part 2. Management of Localized RCC -- Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass Biopsy / Matthew N. Simmons and Steven C. Campbell -- Radical Nephrectomy for Localized Renal Tumors: Optimum Oncological and Renal Functional Considerations / Paul Russo -- Nephron-Sparing Surgery for Renal Cancer / Alon Z. Weizer, Jeffery S. Montgomery and Khaled S. Hafez -- Thermal Ablation / Surena F. Matin and Kamran Ahrar -- Active Surveillance of the Small Renal Mass / Marc C. Smaldone, Daniel Canter, Alexander Kutikov and Robert G. Uzzo -- Part 3. Locally Advanced Disease -- Locally Advanced Renal Cell Carcinoma / Stephen H. Culp and Christopher G. Wood -- Neoadjuvant Targeted Therapy and Consolidative Surgery / Sean P. Stroup and Ithaar H. Derweesh -- Part 4. Advanced Disease -- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects) / Alexandra Arreola and W. Kimryn Rathmell -- Prognostic Factors in Advanced Renal Cell Carcinoma / Michael M. Vickers and Daniel Y. C. Heng -- Integration of Surgery in Metastatic Renal Cancer / Tom Powles and Axel Bex -- Immunotherapy for Renal Cell Carcinoma / Diwakar Davar, Moon Fenton and Leonard J. Appleman -- Targeted Therapy: Vascular Endothelial Growth Factor / Linda Cerbone and Cora N. Sternberg -- Mammalian Target of Rapamycin in Renal Cell Carcinoma / Eric Jonasch and Michel Choueiri -- Palliative and Supportive Care for Renal Cancer / Armida Parala-Metz and Mellar Davis.
    Digital Access  Springer 2013
  • Print
    Mototsugu Ōya, editor.
    Digital Access  Springer 2017
  • Digital
    Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
    Digital Access  Springer 2015
  • Digital
    Robert A. Figlin, W. Kimryn Rathmell, Brian I. Rini, editors.
    Pt. 1. Biology of renal cell carcinoma -- pt. 2. Current and future molecular targets for RCC.
    Digital Access  Springer 2012
  • Digital
    Richard R. Heuser, Markus Schlaich, Horst Sievert, editors.
    This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.
    Digital Access  Springer 2015
  • Digital
    edited by Kevin W. Finkel, Scott C. Howard.
    Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.
    Digital Access  ScienceDirect 2014
  • Digital
    edited by Kate Bramham, MBBS, MA, PhD, MRCP, King's College Hospital NHS Foundation Trust, London, Matt Hall, MBBS, MA, MD, FRCP, Nottingham University Hospitals NHS Trust, Nottingham, Catherine Nelson-Piercy, MBBS. MA, FRCP, FRCOG, Guy's and St. Thomas' NHS Foundation Trust, London.
    Renal physiology / Kate Bramham and Tracy Salter -- Pre-pregnancy counselling and risk assessment / Matt Hall and Liz Lightstone -- Contraception / Kate Wiles -- Assisted reproduction in women with renal disease / Jason Waugh and Ian Aird -- CKD and pregnancy : patterns of care and general principles of management / Lucy Mackillop and Mark Brown -- Midwifery issues / Floria Cheng -- Drugs in women with renal disease and transplant recipients in pregnancy / Graham Lipkin and Asif Sarwar -- Management of hypertension in renal disease in pregnancy / Jenny Myers and Graham Lipkin -- Postpartum follow-up of antenatally identified renal problems / Al Ferraro and Liz Lightstone -- Pregnancy and dialysis / Kainat Shahid, Liam Plant and Michele Hladunewich -- Pregnancy and the renal transplant recipient / Nadia Sarween, Martin Drage and Sue Carr -- Comorbid conditions affecting pregnancy in renal transplant patients / Sue Carr and Joyce Popoola -- Reflux nephropathy in pregnancy / Nigel Brunskill -- Lupus and vasculitis in pregnancy / Liz Lightstone -- Diabetic nephropathy in pregnancy / Andrew McCarthy -- Urological problems in pregnancy / Jonathon Olsburgh and Susan Willis -- Acute renal failure in pregnancy : causes not due to pre-eclampsia / David Williams -- Pre-eclampsia related renal impairment / Louise Kenny -- Renal biopsy in pregnancy / Nigel Brunskill -- Consensus statements 2017.
    Digital Access  Cambridge 2018
  • Digital
    Sara Blakeley (ed.).
    Assessment of Renal Function / Mohan Arkanath -- Imaging of Acute Renal Failure - A Problem-Solving Approach for Intensive Care Unit Physicians / Tom Sutherland -- Drug-Induced Renal Injury / Sara Blakeley -- Acute Kidney Injury / Sara Blakeley -- Medical Management of Acute Renal Failure / Nerina Harley -- Acute Renal Failure in the Surgical Patient / Marlies Ostermann -- Rhabdomyolysis and Compartment Syndrome / Laurie Tomlinson and Stephen Holt -- Multisystem Causes of Acute Renal Failure / Tim Leach -- Therapeutic Plasma Exchange / Tim Leach -- Renal Replacement Therapy / John H. Reeves -- Technical Aspects of Renal Replacement Therapy / Sara Blakeley -- End-Stage Renal Disease / Emile Mohammed -- Clinical Hyperkalemia and Hypokalemia / Harn-Yih Ong -- Clinical Hyponatremia and Hypernatremia / Himangsu Gangopadhyay -- Clinical Metabolic Acidosis and Alkalosis / Sara Blakeley.
    Digital Access  Springer 2008
  • Digital
    Bi-Cheng Liu, Hui-Yao Lan, Lin-Li Lv, editors.
    This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
    Digital Access  Springer 2019
  • Digital
    Leveillee, Raymond J.; Jorda, Merce.
    Digital Access  Springer 2020
  • Digital
    Rhiannon Braund, editor.
    Digital Access  Springer 2020
  • Digital
    Tatjana Antic, Jerome B. Taxy.
    Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
    Digital Access  Springer 2014
  • Digital/Print
    Helmut G. Rennke, M.D., professor of pathology, Harvard Medical School and Harvard-MIT Division of Health Sciences and Technology, Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, Bradley M. Denker, M.D., associate professor of medicine, Harvard Medical School, Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, chief of nephrology, Harvard-Vanguard Medical Associates, Boston, Massachusetts.
    This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design. New color photomicrographs of clinical conditions. Additional end-of-chapter summaries. Up-to-date information based on new medical findings.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2014RC903.9 .R49 20141
  • Digital/Print
    Helmut G. Rennke, Bradley M. Denker.
    "Renal pathophysiology can be a difficult subject even for the most advanced medical students. This Fifth Edition of Renal Pathophysiology: The Essentials provides an easy-to-read, case-based approach to learning the mechanisms of renal disease. Each chapter focuses on a mechanism of kidney disease and includes an opening case, learning objectives, integrated open-ended questions, and chapter-ending summaries. Updated with the latest clinical advances and research, this edition also features full-color illustrations and photomicrographs, suggested readings, and online and in-book Q&As"--Provided by publisher.
    Print AccessRequest Print
    LocationVersion Call NumberNumber of Items
    Books: General Collection (Downstairs)2020RC903.9 .R49 20201
  • Digital
    Larry K. Golightly, Isaac Teitelbaum, Tyree H. Kiser, Dimitriy A. Levin, Gerard R. Barber, Michael A. Jones, Nancy M. Stolpman, Katherine S. Lundin, editors.
    As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes.This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
    Digital Access  Springer 2013
  • Digital
    Larry K. Golightly, Isaac Teitelbaum, Bonita A. Simendinger, Tyree H, Kiser, Gerard R. Barber, Nancy M. Stolpman.
    To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally eliminated medications. This updated edition captures nearly 200 new drugs that have been approved by the FDA since the initial publication of Renal Pharmacotherapy. It also covers new evidence that has emerged regarding the need to adjust dosage of certain older medications that are eliminated by the kidneys. Additionally, it presents new data that are being continuously derived in the areas of patient-specific dose individualization for drugs of all types. Comprehensive, convenient, and evidence-based, this reference closes several identified knowledge gaps and will continue to be the leading collection of dosage recommendations for patients with compromised kidney function.
    Digital Access  Springer 2021
  • Digital
    Bruce M. Koeppen, Bruce A. Stanton.
    "Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book"--Publisher's description.
    Digital Access  ClinicalKey 2019
  • Digital
    Michael J. Field, Carol A. Pollock, David C. Harris ; illustrations by Robert Britton.
    An integrated textbook on the renal system, this volume covers both the basic science of the system and its major diseases. It is geared towards medical students taking system-based, integrated courses.
    Digital Access  ScienceDirect 2010
  • Digital
    Ricardo Muñoz, editor.
    This book is a compilation of scientific knowledge regarding the clinical entity known as "Renal Tubular Acidosis in Children." It contains the information needed to comprehend the intricate mechanisms of acid-base metabolism, electrolyte imbalance, and complications related to renal tubular acidosis in the pediatric age group, since the acid-base physiology and the clinical disorders associated with it in children are quite different from the adult counterpart. The chapters, written by authors, experts in the field, describe systemic and renal physiology, electrolyte alterations, as well as the pathogenesis and chromosomal mutations leading to the development of RTA. The reader will find the latest information on diagnostic tools and learn how to approach diagnosis, avoiding improper treatment, rickets, nephrocalcinosis, and renal failure. In addition, new insights on classification, the clinical presentation of each type of RTA, molecular biology, and transmembrane protein transporters are covered. This work is primarily directed at pediatric nephrologists and pediatricians. Nevertheless, general practitioners, medical students, residents and fellows at different medical training programs, and other health care professionals of nutrition, growth and development, gastroenterology and endocrinology may surely benefit from it.
    Digital Access  Springer 2022

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Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available. DynaMed is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS. Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties. Provides critical assessments of systematic reviews compiled from a variety of medical journals. Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

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Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions. PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians. Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients. A continually updating drug monograph.ECRI Guidelines Trust: A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or products LPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staff Micromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class. LPCH / Stanford Hospital Formulary. A goldmine of trusted consumer health information from the world's largest medical library. A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs. Provides patient handouts from the American Academy of Family Physician. Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users. Vast collection of software and database programming titles from multiple publishers, including Microsoft Press. Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering. Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources. Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals. Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present. A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.