Books

Summary: This book meets the need for a detailed resource that focuses on the unique challenges encountered in pediatric trauma and its clinical management. Short practically oriented chapters describe how to successfully treat a range of injuries across a variety of anatomical areas. Emphasis is placed on accounting for the injury mechanism providing recommendations on rapid assessment, initial stabilization and management strategies. Pediatric Trauma Care - A Practical Guide, comprehensively covers how to approach treating pediatric trauma patients suffering with a variety of injuries. Therefore, it is an ideal resource for all medical professionals who encounter these patients in their day-to-day practice.

Contents:
1 Introduction - (Unique Factors to Pediatric Trauma).-2 Injury Prevention
3 Trauma Systems and Pedaitric Trauma Centers
4 Rural Pediatric Trauma Surgery
5 Disaster Management
6 Pediatric Trauma in Humanitarian and Deployed Settings
7 Initial Trauma Resuscitation
8 Airway Management
9 Management of Shock
10 Blood Tranfusions in Trauma
11 VTE Prophylaxis and Treatment
12 Surgical Nutrition
13 Thromboelastogram
14 Traumatic Brain Injury
15 Facial Injury
16 Neck Injuries
17 Spinal Injury
18 Thoracic Injury (Lung and Chest Wall)
19 Penetrating Abdominal Injury
20 Liver Injury
21 Pancreas, Gallbladder and Duodenum
22 Splenic Injury
23 Gastric Injury
24 Small Bowel/Colon Injury
25 Rectal Injury
26 Perineal (saddle) injury
27 Upper Tract Genitourinary Trauma
28 Lower Tract Genitourinary Trauma
29 Pelvic injury
30 Extremity Orthopedic Injury
31 Injuries to the Hand
32 Vascular Injuries to the Heart and Great Thoracic Vessels
33 Vascular injuries of the Abdominal Vessels
34 Vascular Injuries of the Extremity
35 Envenomation, bites and stings
36 Child Abuse
37 Hypothermia and Near-drowning
38 Burns
39 New Technologies in Pediatric Trauma.

Summary: With hundreds of question and answer items and bite-sized chunks of information that can be read and processed easily, reviewing for the pediatric board exams - or just brushing up in your spare time - has never been easier. Pediatric Tricky Topics, Volume 1: A Practically Painless Review includes review items in pediatric orthopedics, trauma, environmental medicine, toxicology, rheumatology, and neurology topics, among others. The Q&A format allows for self-testing or study with a partner or a group and is practical and accessible enough to dip into during a few minutes of downtime at the hospital or office, and as such it is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills, and any busy clinician who wants to learn more about these topics while on the go.

Contents:
General Orthopedic Question and Answer Items
General Trauma Question and Answer Items
General Environmental Medicine Question and Answer Items
General Toxicology Question and Answer Items
General Prevention Question and Answer Items
General Research and Statistics Question and Answer Items
General Rheumatology Question and Answer Items
Selected Neurology Topics
General Neurology Question and Answer Items.-.

Summary: This book is a unique, authoritative and clinically oriented text on pediatric ultrasound. It is your one-step, comprehensive reference for up-to-date information on pediatric ultrasound, addressing all aspect of congenital and acquired disorders encountered in clinical practice. The easy-to-navigate text is divided into 20 chapters. Each chapter is organized to cover the latest ultrasound techniques, normal development and anatomy, anatomic variants, key clinical presentations, characteristic ultrasound imaging findings, differential diagnosis and pitfalls where relevant. With more than 2000 images, examples of new technological developments such as contrast-enhanced ultrasound and elastography are included. Written by internationally known pediatric radiology experts and editorial team lead by acclaimed authors, Harriet J. Paltiel, MDCM and Edward Y. Lee, MD, MPH, this book is a practical and ideal guide for practicing radiologists, radiology trainees, ultrasound technologists as well as clinicians in other specialties who are interested in pediatric ultrasound.

Contents:
Intro
Preface
Acknowledgments
Contents
About the Contributors and Editors
Contributors
About the Editors
1: Ultrasound Imaging Techniques and Artifacts
Introduction
Acoustics
Wavelength and Frequency
Sound Propagation
Acoustic Impedance
Reflection
Refraction
Attenuation
Distance Measurement
Instrumentation
Transmitter
Transducer
Receiver
Image Display
Image Storage
Mechanical Transducer
Array Transducer
Transducer Selection
Harmonic Imaging
Spatial Compounding
Three-Dimensional Ultrasound
Doppler Ultrasound Continuous Wave Doppler
Pulsed Wave Doppler
Color Doppler
Power Doppler
B-Flow
Elastography Imaging
Quasi-Static Strain Elastography
Dynamic Elastography
Ultrasound Contrast Imaging
Contrast Agents
Pulse Inversion Imaging
Ultrasound Artifacts
Grayscale Artifacts
Mirror Image: Multipath Reflection
Refraction
Reverberation, Comet-Tail, and Ring-Down Artifacts
Side Lobe Artifact
Enhancement and Shadowing Attenuation Artifacts
Partial Volume Artifact
Doppler Artifacts
Technically Related Doppler Artifacts
Inappropriate Doppler Settings Aliasing (Wraparound)
Color Doppler Noise
Flow Directional Abnormalities
Anatomically Related Doppler Artifacts
Spectral Mirror Image Artifact
Tissue Vibration Artifact
Twinkling Artifact
Blooming Artifact
Three-Dimensional Ultrasound Artifacts
Ultrasound Contrast Agent Artifacts
Blooming Artifact
Systolic Peak Velocity Increase
High-Intensity Transient Signals
Ultrasound Safety
Thermal Bioeffects
Nonthermal Bioeffects
Regulations and Policies
References
2: Brain
Introduction
Technique
Patient Positioning Ultrasound Transducer Selection
Imaging Approaches
Normal Development and Anatomy
Normal Development
Normal Anatomy
Cerebral Cortex
Basal Ganglia and Thalami
Ventricles
Cisterna Magna
Extra-Axial Fluid Spaces
Congenital Brain Anomalies
Dorsal Induction Disorders
Chiari Malformations
Anencephaly
Hydranencephaly
Ventral Induction Disorders
Holoprosencephaly
Septo-Optic (Pituitary) Dysplasia
Anomalies of the Corpus Callosum
Dandy-Walker Syndrome
Neuronal Proliferation Disorders
Hemimegalencephaly
Neuronal Migration Disorders Lissencephaly
Gray Matter Heterotopia
Post-Migration Disorders
Polymicrogyria
Schizencephaly
Intracranial Hemorrhage
Preterm Infants
Periventricular Hemorrhagic Infarction
Cerebellar Hemorrhage
Term Infants
Epidural Hemorrhage
Subdural Hemorrhage
Subpial Hemorrhage
Parenchymal Hemorrhage
Choroid Plexus Hemorrhage
Hypoxic-Ischemic Injury
Global Hypoxic-Ischemic Injury
Preterm Infants
Term Infants
Focal Hypoxic-Ischemic Injury
Arterial Ischemic Stroke
Venous Sinus Thrombosis
Sickle Cell Disease
Infectious Brain Disorders

Summary: Ultrasound plays an important role in the diagnostic imaging of infants and children and has indeed become the workhorse for many conditions. This is attributable both to the avoidance of ionizing radiation and to the unique features displayed on ultrasound in children in almost all body areas. In the future the potential of ultrasound can be expected to increase further owing to new developments such as ultrasound contrast material, three- or four-dimensional ultrasound, and ultrasound elastography. This book systematically covers the use of ultrasound in all organ systems and throughout childhood. After discussion of the basics, including physics, artifacts, and procedural details, decision making regarding the use of ultrasound is elucidated by listing next imaging steps based on recommended imaging algorithms. The indications and prerequisites for a particular examination are documented, and practical tips and tricks are highlighted. The normal, age-dependent ultrasound findings and typical appearances in different pathologies are presented in detail and illustrated by numerous high-quality images. Particular emphasis is placed on those findings that differ from the adult sonographic appearances. In addition to the classic pediatric abdominal applications, detailed consideration is given to neurosonography, echocardiography, chest ultrasound, musculoskeletal and hip ultrasound, Doppler sonography, and interventional ultrasound. The potential role of the most modern techniques in various situations is explained. Pediatric Ultrasound will prove an invaluable source of information and an indispensable aid to decision making and diagnosis for radiology residents, experienced (pediatric) radiologists, sonographers, pediatricians, pediatric surgeons and urologists, and all other physicians who deal with children as a part of their daily practice.

Contents:
Basics: Physics of diagnostic ultrasound (US). US techniques. Artifacts. Biological effects of US. Practical US approach. Documentation and reporting. Future US methods. Basics of (Color) Doppler sonography
Diagnostic flow charts, imaging algorithms, and graphs: Urinary tract diseases. Tumors and oncology. Abdomen. Systemic diseases. Graphs and illustrations for standardized measurements and volume calculations
US investigations of various organs and systems: Pediatric cranial neurosonography. US of the neonatal spinal cord. Neck and facial/cervical glands. Chest US. Basics of pediatric and neonatal echocardiography. Abdominal US. Musculoskeletal and other small part US. US-guided interventions.

Summary: This book, now in a revised and updated second edition, systematically covers the use of ultrasound in all organ systems throughout childhood. After discussing the basics, including physics, ultrasound methods, and artifacts, it elucidates decision-making regarding the use of ultrasound by discussing diagnostic flow charts based on recommended imaging algorithms. The main part of the book addresses ultrasound investigations of the various organs. It documents the indications and prerequisites for specific examinations and offers practical tips and tricks. The normal, age-dependent ultrasound findings and typical appearances in different pathologies are presented in detail and illustrated by numerous high-quality images, with a particular emphasis on those findings that differ from the adult sonographic appearances. And finally, dedicated chapters explore point-of-care and emergency ultrasound, interventional ultrasound, and present orienting tables. This state-of-the-art book covers modern techniques and applications, like contrast-enhanced ultrasound, ultrasound elastography, and automated-image optimization, as well as all pediatric ultrasound applications from point-of-care ultrasound and orienting assessment also at the intensive care unit/emergency room to more detailed and advanced applications, e.g., in dedicated tertiary referral centers. Pediatric Ultrasound is an invaluable source of information and an indispensable aid to decision-making and diagnosis for radiology residents, (pediatric) radiologists, sonographers, pediatricians, (pediatric) surgeons, urologists, and all other physicians who deal with children as a part of their daily practice.

Contents:
PART I Basics / Theory / Methods: US Physics
US Methods, artifacts, biologic effects and practice
(Color) Doppler US: theory and artifacts, typical applications in childhood
Contrast-enhanced US, and Ultrasound elastography in childhood
Paediatric limited field of view US/point of care US (POCUS) and emergency US - when, how and for what
Part II Diagnostic flow charts, imaging algorithms, and graphs: Imaging and imaging algorithms for common queries in childhood
Measurements and volume calculations: basic considerations, graphs and illustrations for standardisation
PART III US investigations of the various organs: Neurosonography in Neonates, Infants and Children
US of the neonatal spinal canal and cord
US of the neck in childhood
Basics of pediatric echocardiography
Ultrasound of the Chest
Upper abdominal US in neonates, infants and children
including novel applications
US of the paediatric gastrointestinal tract
Ultrasound of the urogenital tract in neonates, infants and children
Neonatal and pediatric hip US
Musculo-skeletal- & other small part US in childhood
US of peripheral nerves in childhood
PART IV Miscellaneous: US-guided interventions and invasive US procedures, and respective follow-up in childhood
Normal values as relevant for paediatric US.

Summary: The book starts with a short introduction to the topic, followed by a detailed description of the anatomical differences between exstrophy and gastroschisis. In the following chapters, the authors describe the surgical umbilicoplasty for congenital defects in children. Outcomes and complications will be discussed in the last chapter. Written by respected authors, this book will offer residents and fellows as well as practicing and highly experienced plastic surgeons essential guidance on treatment and decision-making concerning umbilical reconstruction. Its numerous illustrations and clearly structured content make the book a must-read.

Contents:
Introduction
Anatomical Differences
History
Pediatric Umbilicoplasty
Exstrophy
Gastroschisis
Urachal Pathology
Complications and Outcomes.

Summary: Sub-specialization within pediatric orthopedics is growing, in part due to the development of free-standing children's hospitals and the desire by patients and their parents to have "experts" care for them. We are at the forefront of a trend in physicians classifying themselves as pediatric upper extremity surgeons. Numerous pediatric hospitals now have or are recruiting physicians to focus their practice in this area. Historically, these issues were treated by general orthopedic surgeons, adult hand surgeons, pediatric orthopedic surgeons, or plastic surgeons. However, none of these professionals treat the entirety of pediatric upper extremity pathology, and no single reference has focused on the treatment of the pediatric upper extremity as a whole. For example, fractures have typically been written about in pediatric textbooks, while tendon and nerve injuries are covered in adult hand textbooks. This textbook is a comprehensive, illustrated reference that discusses all aspects of the pediatric upper extremity, from embryology and functional development to nerve injuries, trauma, tumors, burns, sports injuries and more.

Contents:
I: DEVELOPMENT
Embryology
Functional development
II: PHYSICAL EXAMINATION
Physical examination
Outcome measures
III: IMAGING
IV: ANESTHESIA
V: OCCUPATIONAL THERAPY
Splinting and casting
Occupational therapy evaluation and treatment
VI: CONGENITAL DIFFERENCES
Introduction to congenital differences and genetics
Failure of formation
Failure of differentiation
Duplication
Overgrowth
Undergrowth
Constriction band syndromes
Metabolic and endocrine abnormalities
Genetic syndromes
Skeletal dysplasias
VII: NERVE
Nerve anatomy and diagnostic evaluation
Ulnar nerve injury
Median nerve injury
Radial nerve injury
VIII: BRACHIAL PLEXUS PALSY
Obstetrical brachial plexus palsy
Microsurgery for obstetrical brachial plexus birth palsy
Glenohumeral joint secondary procedures
Elbow flexion secondary procedures
Traumatic brachial plexus injuries
IX: TETRAPLEGIA
Introduction to tetraplegia
Treatment
X: NEUROMUSCULAR: Cerebral palsy
Arthrogryposis
XI: TRAUMA
Multiply injured child
Non-accidental trauma
Nail bed injuries
Flexor tendon injuries
Extensor tendon injuries
Amputations/replantation
Phalangeal fractures
Metacarpal fractures
Hand dislocations
Carpal fractures
Distal radius fractures
Forearm fractures
Monteggia fracture dislocations
Galeazzi and Essex Lopresti injuries
Pediatric elbow and supracondylar fractures
Distal articular humerus fractures
Medial epicondyle fractures, elbow dislocations, and transphyseal separations
Radial head, neck and olecranon fractures
Proximal humerus and humeral shaft fractures
Clavicle fractures, AC dislocations, SC dislocations and scapula fractures
XII: INFECTIONS
Hand infections
Cellulitis and necrotizing fasciitis
Osteomyelitis and septic arthritis
XIII: TUMORS
Benign soft tissue lesions
Benign bony lesions
Malignant lesions
XIV: COMPARTMENT SYNDROME
XV: SKIN LESIONS
Congenital lesions
Acquired lesions
XVI: BURNS
XVII: VASCULAR DISORDERS
XVIII: RHEUMATOLOGIC DISORDERS
XIX: FACTITIOUS DISORDERS
XX: SPORTS INJURIES
Caring for the athlete
The throwing athlete
The gymnast
XXI: ARTHROSCOPY
Wrist
Elbow
Shoulder
XXII: OTHER TOPICS
Trigger digits
Kienbock's disease
Madelung's deformity
Torticollis and Sprengel's deformity
Multi-ligamentous laxity
Thoracic outlet syndrome
Prostheses.

Summary: While there are Pediatric Urology texts for pediatric urologists and for general urologists, there are none for primary care physicians. This book is written specifically for the primary care physician, the initial contact for the many children with urologic conditions. The text will assist the primary care physician in the recognition of and participation in the care of children with these common problems including both congenital and acquired conditions. Specific chapters are also dedicated to the management of cases that may include medical and/or surgical intervention. The contributing authors of this text were selected for their internationally recognized expertise and straight forward educational styles in the field of Pediatric Urology. Pediatric Urology for the Primary Care Physician will significantly help our primary care colleagues in the evaluation and management of children with genito-urinary problems.

Contents:
Fetal Hydronephrosis
Multicystic Dysplastic Kindney
Renal Agenesis and Associated Anomalies
Renal Duplication Anomalies
Ureteropelvic Junction Obstruction in the Pediatric Population
Pediatric Renal Trauma
Renal Stones
Rediatric Renal Tumors
Ureteroceles
Megaureter
Ectopic Ureter
Cystitis
Vesicoureteral Reflux
Posterior Urethral Valves
Bladder Exstrophy for the Primary Care Provider
Daytime Wetting
Tumors of the Lower Genitourinary Tract in Children and Adolescents
Pediatric Hernias and Hydroceles
Retractile Testes
Undescended Tests
Testicular Torsion
Testis Tumor
Adolescent Varicocele
Phimosis
Paraphimosis
Meatal Stenosis
Balanitis
Urethrorrhagia
Urethral Stricture
Hypospadias
Chordee
Epispadias
Female External Genitalia for Primary Care Providers
Ambiguous Genitalia
Myelodysplasia: From Birth to Adulthood
Continent Urinary Diversion
Managing Pediatric Lower Urinary Tract Dysfunction and Associated Constipation in the Primary Care Setting
Pyelonephritis
Nephrologic Aspects of Urologic Disease
Pediatric Primary Nocturnal Enuresis (Bedwetting).

Summary: "This handy visual aid guides clinicians in discussions with patients and parents about the importance of vaccines, the diseases they help prevent and the various vaccines recommended. The chart includes infographics and clinical images to help illustrate why vaccines remain important in preventing diseases. Vaccines covered include influenza, varicella (chickenpox), human papillomavirus, polio, meningitis, and much more. The chart also includes information for health care professionals about the origin and nature of the diseases and current recommendations for vaccine schedules. In addition, it provides steps to take when a child or community is exposed to a potential infection, including prophylaxis and reporting to local health departments"--Publisher's description.

Contents:
DTaP, Tdap, Td
Haemophilus influenzae type B (HIB)
Hepatitis A and B
Human papillomavirus (HPV)
Influenza (“flu”)
Measles-mumps-rubella (MMR)
Meningococcal infections
Pneumococcal infections
Polio
Rotavirus
Varicella (chickenpox).

Summary: This book is a detailed resource on the technical aspects of pediatric neurosurgery that relate to vascular malformations of the brain and spinal cord. It introduces concepts relevant to cerebrovascular system development and the classification of vascular malformations. Information on a range of disorders is then provided with an emphasis placed on answering frequently asked questions in relation to a particular condition. Therefore, enabling the reader to systematically improve their understanding of how approach treating patients utilizing techniques such as ultrasound and spinal angiography. The chapters, authored by experts in their respective field, provide a standard of care based on current diagnostic and management guidelines for pediatric neurosurgical diseases. Pediatric Vascular Neurosurgery: Technical Nuances in Contemporary Pediatric Neurosurgery (Part 2) is a comprehensive overview of how to approach diagnosing and treating a range of vascular malformations encountered in pediatric patients. The problem-solving approach of this work makes it a valuable addition to the literature and suitable for use by residents, fellows and consultants within pediatrics and allied specialities, including Neurosurgery, Neurology, Neuro-anesthesia, Neuro-critical care and advanced health care providers amongst others.

Summary: With the proliferation of research studies posted online, media outlets scrambling to pick up stories, and individuals posting unverified information via social media, the landscape for parents trying to understand the latest science as it pertains to their children has never been more challenging to navigate. This book is intended to assist pediatricians when discussing research findings with parents. It provides an overview of research practices and terminology, clarifies misconceptions about studies and findings, and explains the limitations of research when applied to medical decision making. Through this framework, physicians can explain their reasoning behind specific clinical recommendations. In addition to examining the broad concepts comprising research literacy, this book reviews the current findings in topics that pediatricians report discussing most often with parents, such as vaccines, diet, medications, and sleep. Pediatrician's Guide to Discussing Research with Patients is a unique resource for pediatricians in encouraging the development of research literacy in their patients.

Contents:
1 Introduction
2 Funding and Bias
3 Study Design and Related Considerations
4 Significance: Statistical versus Clinical
5 Incorporating Research into Health Care Decisions
6 Vaccines
7 Diet
8 Food Allergies
9 Discipline Techniques
10 Medications
11 Sleep
12 Screen Time
13 School Refusal
14 Infectious Diseases.

Summary: This book provides a comprehensive review of what comes after the completion of a pediatrics residency. Chapters review several areas of fellowships and how to navigate through the application process, provide a guide for finding a job and negotiating through your first position, and also discuss other difficult topics such as how to deal with malpractice lawsuits. The book is comprised of six parts. Part 1 explains pediatric fellowships, including how to apply, prepare, and choose your ideal fellowship. Part 2 describes what to expect on your first job search and what to consider when choosing a career path. Part 3 and Part 4 aim to prepare readers for what happens after finding and starting a job in pediatrics, such as moving, setting up an office, supervising residents, and how to deal with difficult patients. Part 5 discusses long term goals and planning, which helps prepare readers for the long road ahead. This includes pursuing partnerships, additional degrees, and training. It also shares knowledge on how to manage medical school debt, retirement planning, switching jobs, and much more. Finally, Part 6 aims to help readers maintain their personal health and family life by setting boundaries, managing stress, and discussing ways to avoid burnout. Written by experts in the field, A Pediatrician's Path: What to Expect After a Pediatrics Residency is a valuable resource for pediatricians, residents and medical students interested in a career in pediatrics.

Contents:
Applying for Fellowship
Adolescent Medicine
Pediatric Critical Care
Pediatric Emergency Medicine
Pediatric Endocrinology
Pediatric Gastroenterology
Pediatric Infectious Diseases
Neonatal-Perinatal Medicine
Pediatric Palliative Care
Post Pediatric Portal Program Fellowship
Completion of Multiple Fellowships: finding a Job
Your First Job: Where to Look
Applications and Interviews
Contract Considerations: Preparation
Contract Considerations: Understanding the Contract
Choosing a Career in Academic Medicine
Choosing a Career as a Pediatric Hospitalist
Choosing a Career in Private Practice
Choosing a Career in Public Health
Choosing a Career in Pediatric Urgent Care
Choosing a Career in Direct Primary Care
Non-clinical Roles
Moving
Licenses, Credentials, and Privileges
Setting Up Your Office
Risk Management and Patient Safety
Mentorship
Patient Experience
Preparing for Your First Day
Daily Considerations
Electronic Health Records
Asking for Help
Impostor Syndrome
Supervising Residents
Balancing Resident Autonomy and Patient Safety
Working with Advanced Practice Providers
Research
Staff Considerations
Billing and Insurances
Pediatric Boards, Continuing Medical Education, and Maintenance of Certification
How to Deal with a Difficult Patient
Keeping up to Date is more than UpToDate
Pursuing Partnership in a Private Practice
Pursuing Additional Degrees and Training
Your 5 and 10 Year Plan
Disability Insurance 101
Life Insurance 101
Managing Your Medical School Debt
Retirement Planning
Switching Jobs
Your Side Hustle
Your Online Presence
Personal Health and Family Life
Setting Boundaries
Stress Management
Developing Interests Outside of Medicine and Avoiding Burnout.

Summary: "BRS Pediatrics is a comprehensive review of general and subspecialty pediatrics aimed for medical students on their core clerkship in pediatrics. Written in the popular Board Review Series outline format, this text presents the essentials of pediatrics through concise descriptions, clinical correlations, numerous figures and nearly 100 tables. This revision will include over 500 board-style questions with complete answers and explanations, with exams at the end of each chapter and an end-of-book Comprehensive Examination"-- Provided by publisher.

Contents:
Pediatric health supervision
Behavioral and developmental pediatrics
Adolescent medicine
Neonatology
Genetic disorders and inborn errors of metabolism
Endocrinology
Infectious diseases
Cardiology
Pulmonology
Gastroenterology
Nephrology and urology
Neurology
Hematology
Oncology
Allergy and immunology
Rheumatology
Orthopedics
Ophthalmology
Dermatology
Emergency medicine.

Contents:
General pediatrics
The newborn infant
The cardiovascular system
The respiratory system
The gastrointestinal tract
The urinary tract
The neuromuscular system
Infectious diseases and immunology
Hematologic and neoplastic diseases
The adolescent.

Summary: "The PreTest Clinical Science Series prepares medical students for the USMLE Step 2 CK, which assesses students' medical knowledge of core clinical topics with USMLE style review questions. Useful as reviews for clerkship exams following core clinical rotations, each PreTest book contains 500 questions with comprehensive, targeted answers and rationale. Discussions review correct and incorrect answer options to reinforce learning. The 15th edition of Pediatrics: PreTest simulates the USMLE Step 2 CK test-taking experience by including vignette-style questions and updates on the latest treatments and therapies for infants, children and adolescents. To ensure that questions are representative of the style and level of difficulty of the exam, each PreTest book is reviewed by students who either recently passed Step 2CK or completed their Pediatrics rotation"-- Provided by publisher.

Contents:
Adolescent medicine and gynecology / Gayathri Chelvakumar and Paula Cody
Allergic and immunologic disorders / Amy O. Thomas and Alex Thomas
Behavioral and mental health issues / Linda J. Cooper-Brown and Jennifer McWilliams
Blood and neoplastic disorders / Adam D. Wolfe
Cardiology / Benton Ng
Cognition, language, and learning disabilities / Amy L. Conrad, Todd Kopelman, and Tammy L. Wilgenbusch
Collagen vascular and other multisystem disorders / Sandy Hong and Kelly E. Wood
Critical care / Ashley Loomis and Niyati Patel
Ear, nose and throat disorders / Derek Zhorne
Emergency care / Sarah L. Miller
Endocrine disorders / Vanessa Curtis
Ethics / Becky Benson
Eye disorders / Melanie Schmitt
Fetus and newborn / Erin Osterholm
Fluids and electrolyte metabolism / Jeff Van Blarcom
Pediatric gastroenterology / Dina Al-Zubeidi
Genetics and dysmorphology / Greg Rice
Genital system disorders / Kathleen Kieran
Growth and development / Erin Howe
Infectious disease / Nathan Price
Metabolic disorders / Eric T. Rush
Musculoskeletal disorders / Natalie Stork and Blaise Nemeth
Neurologic disorders / Satsuki Matsumoto and Leah Zhorne
Nutrition / Kelly E. Wood
Patient safety and quality improvement / Elizabeth H. Mack
Pharmacology. Part I, Pharmacology and pain management / Susan S. Vos, Gary Milavetz, Jeff Van Blarcom, and Laura Steinauer
Pharmacology, Part II, Sedation / Jeff Van Blarcom
Poisoning and environmental exposure to hazardous substances / Christopher Hogrefe
Preventative pediatrics / Ashley Miller and Rebecca Lozman-Oxman
Psychosocial issues & child abuse. Part 1, Psychosocial issues / Cassandra Collins, James Burkhalter, and Kelly E. Wood
Psychosocial issues & child abuse. Part 2, Child abuse / Cassandra Collins, James Burkhalter, and Kelly E. Wood
Research and statistics / Andrew R. Peterson
Renal and urologic disorders / Jen Jetton and Kathy Lee-Son
Respiratory disorders / Anthony Fischer
Skin disorders / Will Aughenbaugh and Lisa Muchard
Sports medicine and physical fitness / Andrew R. Peterson
Substance abuse / LaTisha L. Bader and Ross Mathiasen.

Summary: This book provides extensive information on pedophilia (sexual interest in the prepubescent body age), hebephilia (sexual interest in the early-pubescent body age) and sexual offenses against children, i.e., the various forms of child sexual abuse, including the use of child sexual abuse images, along with the current state of knowledge concerning offender groups. The book makes it clear that pedophilia or hebephilia do not inevitably lead to offenses against children - that there are those who keep their desires in their fantasies and do not act them out on the behavioral level. The World Health Organization classifies pedophilia as a mental disorder. It can be safely assumed that many pedophile men in a given community live their lives, unrecognized and adamant about hiding their sexual drives from society and from themselves, and who are genuinely motivated not to act upon their sexual fantasies. The numbers of exactly this particular group of pedophilically inclined non-offenders can be increased by preventive therapeutic measures. For this purpose, two treatment programs have been developed at the Institute of Sexology and Sexual Medicine at the Charité-Universitätsmedizin Berlin (University Clinic) since the initiation of the Prevention Project Dunkelfeld in 2005 - First, the project involving adult participants (Berlin Dissexuality Therapy: BEDIT) and later, another for adolescents (BEDIT-A), who find themselves attracted to children. Both program manuals are completely integrated into this work, which reflects 15 years of assessment and treatment experience.

Contents:
1. Pedophilia and Hebephilia
2. Child Sexual Abuse and the Use of Child Sexual Abuse Images
3. Therapeutic Options
4. The Berlin Prevention Project Dunkelfeld
5. BEDIT-Manual for Adults
6. Modules for Adults
7. BEDIT-A Manual for Adolescents
8. Modules for Adolescents
9. Worksheets BEDIT
10. Worksheets BEDIT-A.

Summary: The book serves as a guide for all clinicians seeking to improve healthcare outcomes by implementing peer support in the treatment and management of medical and mental health conditions. The book begins with a chapter that describes the importance of peers and how peers are increasingly being utilized to improve medical outcomes. Each chapter opens with an introductory section, include tables and figures, and ends with a summary section for quick reference. Written by experts in the field, this resource covers the clinical implications for peer support in substance misuse, chronic medical conditions, in special populations, and mental illness generally. Each chapter is designed specifically to be accessible for a broad clinical audience of experts and non-experts across medical specialties. Peer Support in Medicine is an excellent resource for all clinicians seeking to improve healthcare outcomes using the gains made by the peer support model, including psychiatrists, psychologists, healthcare researchers, and medical students across specialties, nurses, social workers, and all others.

Contents:
Introduction
Peer Support for Substance Use Disorders
Peer Support for Mental Illness
Peer Support for Chronic Medical Conditions
Peer Support for Bereavement
Peer Support for Adolescents
Peer Support for Elderly
Peer Support for Families
Peer Support for the Medical Community.

Summary: The fully comprehensive book brings together the three main pelvic specialties (Urology, Gynecological Oncology and Colorectal Surgery) into one volume. Patients have been shown to benefit from a multidisciplinary approach since it allows surgeons of different specialties to learn from one another therefore enhancing the treatment for the patient. Pelvic cancer outcomes are poor in low volume centres. These centres account for 80% of the global centres dealing with these cancers. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is a much needed book that can focus training and assist health professionals in their care of patients with pelvic dysfunction. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is complete with full color illustrations and schematic diagrams and makes use of key points and stepwise figures for an enhanced learning experience.

Summary: This excellent textbook provides up-to-date information on all aspects of pelvic floor disorders. After an opening section on anatomy and physiology, it explains the methodology, role and application of the integrated imaging approach in detail, including the most advanced 3D, 4D, and dynamic ultrasound techniques, illustrated with hundreds of images. It then discusses in depth the epidemiology, etiology, assessment, and management of the full range of pelvic floor disorders from multidisciplinary and practical perspectives. The book also provides information on the various forms of obstetric perineal trauma, urinary incontinence and voiding dysfunction, anal incontinence, pelvic organ prolapse, constipation and obstructed defecation, pelvic pain and sexual dysfunction, and fistulas, and includes treatment algorithms as well as helpful guidance on what to do when surgical treatment goes wrong. The authors are leading experts in the field from around the globe. Since the first edition from 2010 (more than 200,000 chapter downloads), the book has been extensively rewritten and features numerous additional topics. The result is a comprehensive textbook that is invaluable for gynecologists, colorectal surgeons, urologists, radiologists, and gastroenterologists, beginners and veterans alike.

Summary: During recent decades, more than 100 surgical procedures have been proposed to treat pelvic organ prolapse, and surgeons are still searching for the ideal approach. Although generally accepted guidelines and algorithms are still lacking, careful preoperative work-up and patient selection can serve as a sound basis for tailored surgery. In this comprehensive book, leading experts from around the world provide a detailed, up-to-date overview of the diagnostic and surgical approaches employed in patients with prolapse of the middle or posterior pelvic floor compartment. Each surgical technique is explained step by step with the aid of instructive figures. Guidance is also included on the management of surgical complications and of recurrent disease aspects that are too frequently overlooked in the scientific literature. This book will prove essential reading for all who are interested in functional colorectal disorders of the pelvic floor and will represent a unique and invaluable source of knowledge for general surgeons, colorectal surgeons, and urogynecologists, whether in training or practice.

Contents:
The Multidisciplinary View of a Pelvic Floor Unit
Epidemiology and Prevalence of Pelvic Floor Disorders
Pelvic Floor Anatomy
Imaging of Pelvic Floor Disorders
Anorectal Physiology
Pelvic Floor Ultrasonography
Pelvic Floor Ultrasonography
Fecal Incontinence
Obstructed Defecation Syndrome
Solitary Rectal Ulcer Syndrome and Obstructed Defecation: Common Pathology
Chronic Anorectal Pain: Pathophysiological Aspects, Diagnosis, and Treatment
Biofeedback and Pelvic Floor Disorders
Biofeedback Training and Physiokinetic Therapy
STARR and TRANSTARR Procedures
Delorme's Procedure
The Altemeier's Procedure for External Rectal Prolapse
The Express Procedure for Internal Rectal Prolapse
Transperineal Rectocele Correction
Mesh Rectopexy (Ripstein, Orr-Loygue, Wells, and Frykman-Goldberg)
Rectopexy without Mesh
Laparoscopic Ventral Rectocolpopexy for Rectal Prolapse Syndromes: Restoration of Anatomy and Improvement of Function
Pelvic Organ Prolapse Suspension.

Summary: This text provides a comprehensive, state of the art review of this field and will serve as a resource for urologists, colorectal surgeons, geriatricians, and gynecologists as well as researchers interested in neuromuscular phenomena in the pelvis. The book also reviews new data regarding risk factors for pelvic floor muscle dysfunction and profiles new minimally invasive surgical strategies for well known pelvic disease processes. Each chapter is chock full of data from landmark trials which have been published over the past few years and placed in context with respect to current management techniques for pelvic floor disorders. Written by experts in their field, Pelvic Floor Dysfunction and Pelvic Surgery in the Elderly: An Integrated Approachprovides a concise yet comprehensive summary to help guide patient management.

Contents:
1. Principles of Ultrasound and Instrumentation
2. Functional Anatomy and Approaches to Imaging of the Pelvic Floor
3. Essentials for Setting Up Practice in Clinician Performed Ultrasound
4. Ultrasound Imaging in Assessment of the Male Patient with Voiding Dysfunction
5. The Female Patient 1- Assessment of Female Voiding Dysfunction
6. The Female Patient 2- Pelvic Organ Prolapse
7. Imaging of Gynaecologic Organs
8. Ultrasound Assessment of the Patient with Fecal Incontinence
9. 3D Ultrasound Imaging of the Pelvis.

Summary: “Pelvic Pain and Dysfunction: A Differential Diagnosis Manual is a comprehensive guide on the management of patients suffering from pelvic pain as well as dysfunction of the bowel and bladder systems. It integrates differential diagnosis concepts of orthopaedic medicine to the urogynecological patient. Using the concepts described, clinicians will have the opportunity to readily determine the underlying cause of their patients? suffering, and a means to ameliorate their pain and dysfunction. Regardless of chronicity, the strategies outlined have proven effective in restoration of function and comfort.” - Provided by publisher

Contents:
Introduction to pelvic pain
General concepts
Evaluation
Interpretation
Management.

Contents:
Pelvic pain management : an introduction / Louis Saddick, Richard D. Urman, and Assia T. Valovska
Anatomy of the abdomen and pelvis / Mona Patel and Assia T. Valovska
Pain mechanisms in chronic pelvic pain / Juan Diego Villegas-Echeverri, J.D. López-Jaramillo, A.L. Herrera-Betancourt, J.D. López-Isanoa, and M.P. Pardo-Bustamante
Multidisciplinary approaches to pelvic pain treatment : a physical therapist's perspective / Stephanie Prendergast
Pharmacologic management of pelvic pain / Michelle L. Matthews and Vesela Kovacheva
Dyspareunia and vulvodynia / Adeoti Oshinowo, Alin Ionescu, Tanya Anim, and Georgine Lamvu
Endometriosis : treatment and pain management / Karina Gritsenko
Painful bladder syndrome and interstitial cystitis in women / Sybil Dessie and Eman Elkadry
Functional abdominal pain syndrome / Karina Gritsenko
Pudendal neuralgia / Michael Hibner and Mario Castellanos
Incapacitating pelvic congestion syndrome / Neeraj Rastogi, Nii-Kabu Kabutey, Gillian Lieberman, and Ducksoo Kim
Male pelvic pain / Michel A. Pontari and Emmanuel A. Ghormoz
Musculoskeletal causes of pelvic pain / Chris R. Abrecht, Lesley E. Bobb, and Assia T. Valovska
Pelvic cancer pain / Karina Gritsenko
Surgical treatment of pelvic pain / Adam Duke, Elmira Manoucheri, and Karen Wang
Chronic pelvic pain and psychological disorders / Mohammed Issa and Raheel Bengali
The physical therapy approach to pelvic pain : evaluation
/ Lila Bartkowski-Abbate and Amy Stein
The physical therapy approach to pelvic pain : treatment / Amy Stein
Implantable devices for the treatment of pelvic pain / Chris R. Abrecht, Alison M. Weisheipl, and Assia T. Valovska
Sample clinical cases / Sawsan (Suzie) As-Sanie, Nichole Mahnert, and Beth Skinner.

Summary: This book provides in-depth coverage of all aspects of pelvic ring fractures and their management. The opening chapters supply essential information on surgical anatomy, biomechanics, classification, clinical evaluation, radiological diagnostics, and emergency and acute management. The various operative techniques, including navigation techniques, that have been established and standardized over the past two decades are then presented in a step-by-step approach. Readers will find guidance on surgical indications, choice of approaches, reduction and fixation strategies, complication management, and optimization of long-term results. Specific treatment concepts are described for age-specific fractures, including pediatric and geriatric injuries, and secondary reconstructions. Pelvic ring fractures represent challenging injuries, especially when they present with concomitant hemodynamic instability. This book will help trauma and orthopaedic surgeons at all levels of experience to achieve the primary treatment aim of anatomic restoration of the bony pelvis to preserve biomechanical stability and avoid malunion with resulting clinical impairments.

Contents:
Chapter 1 The History of Pelvic Fracture Treatment
Chapter 2 Surgical Anatomy of the Pelvis
Chapter 3 Biomechanics of the Pelvis
Chapter 4 Classification of Pelvic Ring Injuries
Chapter 5 Prehospital Treatment of Suspected Pelvic Injuries
Chapter 6 Inhospital Clinical Examination
Chapter 7 Radiological Diagnostics
Chapter 8 Introduction
Emergency Management
Chapter 9 Emergency Stabilization
Pelvic Binder
Chapter 10 Emergency Management
Pelvic C-Clamp
Chapter 11 Mechanical Stabilization: DC-Osteosynthesis
Chapter 12 Pelvic Packing
Chapter 13 Direct Hemorrhage Control: Vascular DC-Treatment
Chapter 14 Emergency Management
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
Chapter 15 Indirect Hemorrhage Control: Angiography/Embolization (AE)
Chapter 16 Coagulation Management
Chapter 17 Open Pelvic Fractures
Chapter 18 Morel-Levallee Lesions
Chapter 19 Pelvic Compartment Syndrome
Chapter 20 Traumatic Hemipelvectomy
Chapter 21 Urological Trauma
Chapter 22 Principles of Treatment of Pelvic Ring Injuries
Chapter 23 Symphyseal Disruption
Chapter 24 Retrograde Pubic Rami Screw
Chapter 25 External Fixation
Chapter 26 Subcutaneous Anterior Pelvic Fixation
Chapter 27 Ilium Fractures
Chapter 28 Anterior Plating SI-joint
Chapter 29 SI-joint
Posterior Reduction and Stabilization
Chapter 30 Fracture Dislocations of the SI-joint
Chapter 31 Iliosacral Screw Fixation
Chapter 32 Local Sacral Plating
Chapter 33 Lower Transverse Sacral Fractures
Chapter 34 Ilio-iliacal Osteosynthesis
Chapter 35 Lumbopelvic Fixation
Chapter 36 Pediatric Pelvic Ring Injuries
Chapter 37 Avulsion Injuries
Chapter 38 Fragility Fractures
Chapter 39 Intraoperative 3D Imaging of the Pelvic Ring
Chapter 40 Implant Removal
Chapter 41 Infectious Complications After Pelvic Ring Surgery
Chapter 42 Pelvic Malunion and Non-Union
Chapter 43 Outcome After Pelvic Ring Injuries.

Contents:
I. Introduction
II. Historical & cultural perspective
III. Penis anatomy
IV. Patient selection and counselling
V. Psychologic perspective
VI. Preoperative preparation and postoperative care
VII. Girth Enhancement
Dermal, dermofat graft
Fat graft
Penile disassembly & Glans detachment
Glans augmentation
Injectable Filler
Allograft and synthetic injectables
Silicon
Paraffin injection
Tissue Engineering
Stem Cell.- VIII. Penile Lengthening
VY plasty
Z-plasty.- Double-Z plasty
Suspensory ligament release/division/ligamentolysis
Penile lengthening device.
IX. Pediatric perspective
micropenis, concealed penis, webbed penis, penoscrotal transposition
Correction of webbed penis
Correction of concealed penis
Correction of penoscrotal transposition
X. Penile reconstruction of amputated penis
forearm cutaneous fascial graft.

Summary: This fully updated and revised second edition address specifically some of the significant advances made in our understanding of the pathophysiology of penile cancer including discussion of the suspected role of the human papilloma virus in penile carcinogenesis. Similarly, the molecular pathways implicated in precancerous and penile cancer will be discussed as these are the present targets of novel therapeutic approaches to this disease. The text details the recent national and international diagnostic and treatment guidelines that have been developed by both the National Comprehensive Cancer Network© and the European Urological Association establishing evidence based standards upon which the care of penile cancer should be based. The text also covers significant advances made in the diagnostic and therapeutic approach to both primary tumors and inguinal nodal metastases resulting from penile cancer such as penile sparing surgery and minimally invasive inguinal lymph node surgery. The text will similarly highlights the improvement in cancer specific outcome in the management of loco-regionally advanced (N2/3) penile cancer managed by upfront systemic chemotherapy followed by consolidative surgery in appropriately selected patients based on recent prospective phase II data. It also covers the role of radiotherapy in the management of penile cancer for both primary tumors and/or at sites of regional or distant metastases. Finally, some of the novel systemic approaches being devised in the management of advanced penile cancer along with some upcoming international trials soon to be opened which likely will re-define the present therapeutic approaches to penile cancer are discussed. The Second Edition of Penile Cancer: Diagnosis and Treatment will constitute a comprehensive review of the above mentioned subjects in addition to a few select topics of high clinical relevance, with the readership predominantly consisting of urologists, medical and surgical oncologists, and other healthcare professionals.

Contents:
Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions
Diagnostic Tools in the Evaluation and Management of Penile Cancer
Penile-Sparing Surgical Approaches in the Management of Primary Penile Tumours
Dynamic Sentinel Node Biopsy and FDG-PET/CT for Lymph Node Staging in Penile Cancer
Surgical Decision Making, Technical Considerations and Clinical Pearls in Therapeutic Inguinal Node Dissection Surgery for Penile Cancer
Minimally Invasive Surgical Approaches to Inguinal Nodes in the Absence of Palpable Adenopathy
Pelvic Lymph Node Dissection for Penile Cancer: Answering the Conundrum of When and How It Should Be Conducted
Multmodal Approach to Locally Advanced and Metastatic Penile Cancer
The Role of Radiotherapy in the Management of Penile Cancer.

Summary: This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families. Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.

Contents:
Mechanism of Carcinogenesis and Progression
Pathologic Features of Invasive Penile Carcinomas and Precursor Lesions
Characterization of Penile Cancers with Comprehensive Genomic Profiling
Functional and Psychosocial Impact of Penile Cancer Treatments
Penile Sparing Surgical and Non-Surgical Approaches
Management of Primary Penile Tumors - Partial and Total Penectomy
In the Clinical Setting of Non-Palpable/Non-Bulky Inguinal Nodes
Management of Bulky Inguinal/Pelvic Metastases in Squamous Penile Cancer
Neoadjuvant and Adjuvant Multimodality Treatments for Patients with Lymph Node Involvement
Management of Locally Recurrent Penile Cancer
Management of Metastatic Penile Cancer
Overview of Insightful Systemic Approaches
Clinical Trials Corner.

Summary: Penile implants have been an effective treatment for erectile dysfunction (ED) for more than 40 years. However, there is now a growing interest in this treatment option, as the number of procedures is expected to increase in the future. This book offers a reference guide for all those practitioners interested in understanding and/or performing this procedure. It will also benefit those in medical education who want to obtain specialized and high-quality knowledge regarding the complexities involved in penile implant surgery. Although the basic description of penile implant surgery is well documented in the literature, a detailed and comprehensive guide with a special focus on the most challenging and controversial aspects is lacking. The few books available on the topic provide a broad overview of prosthetic surgery in general, mainly discuss basic principles, and fail to provide a more detailed perspective. This comprehensive book discusses various aspects of penile implant surgery, ranging from indications to long-term complications. It addresses the most common and serious challenges regarding penile implants, which are rarely discussed elsewhere. The respective chapters were written by internationally respected experts on the controversies of penile prosthetic surgery. The book is intended for all those who plan to specialize in penile implant surgery, which include, but are not limited to, residents and fully trained urologists, as well as fellows and practitioners in sexual medicine and reconstructive urology.

Contents:
Patient and Device Selection
Critical Analysis of Maneuvers to Reduce Infection in Penile Implant Surgery
Strategies for Optimal Pain Control in the Penile Implant Patient
Implant Surgery in the Anticoagulated Patient
Management of Residual Curvature in the Patient with Peyronie's Disease Undergoing Penile Implant Surgery
Considerations in Reservoir Placement
The Hostile Penis: Managing the Patient with Penile Fibrosis
The Role of Penile Lengthening Procedures at the Time of Penile Implant Surgery
Considerations in the Management of Visceral Perforation During Penile Implant Surgery
Implant Surgery in the Patient with Neophallus
Approach to Managing the Patient with Impending Erosion
Management of Long-term Complications of Penile Implant Surgery
Medicolegal Aspects of Penile Implant Surgery.

Summary: Brief, well-illustrated chapters, an easy-to-read format, and a convenient, portable size make Penn Clinical Manual of Urology, 3rd Edition, your go-to resource for fast reference on the effective diagnosis and treatment of urologic disorders. Concise and practical, this manual is indispensable for both residents and practitioners as a daily clinical guide as well as an outstanding review tool for board exam preparation.

Contents:
Signs and symptoms: The initial examination
Diagnostic and interventional uroradiology
Lower urinary tract infections in women and pyelonephritis
Lower urinary tract infection in males
Specific infections of the genitourinary tract
Sexually transmitted infections
Interstitial cystitis/bladder pain syndrome
Urolithiasis in the adult
Penn clinical manual chapter on urologic emergencies
Urinary and genital trauma
Urethral stricture and lower urinary tract reconstruction
Urinary fistula
Nocturia
Lower urinary tract function and dysfunction; urinary incontinence
Benign prostatic hyperplasia and related entities
Adult genitourinary cancer: Prostate and bladder
Adult genitourinary cancer: Renal and testicular
Adult genitourinary cancer: Urethral and penile
Radiation therapy
Laparoscopic surgical anatomy, laparoscopy, and robotic-assisted laparoscopic surgery
Male sexual dysfunction
Male fertility and sterility
Disorders of the adrenal gland
Retroperitoneal tumors and retroperitoneal fibrosis
Embryology and differences of sex development
Congenital anomalies
Pediatric oncology
Pediatric urolithiasis
Pediatric voiding function and dysfunction
Transitional urology
Geriatric urology
Quality and safety considerations in urology
Clinical research design and statistics.

Summary: "The original textbook by Dr. Susan Penner was written 20 years ago as the Introduction to Health Care Economics and Financial Management: Fundamental Concepts with Practical Application. It has helped nurses, nurse leaders, students, and faculty to understand, develop knowledge, and gain competency in the often complex world of finance and economics. It has been a very thorough and practical book for both the classroom and practice environments. We want to thank Dr. Penner for her vision and the execution of a resource that has stood the test of time and changing healthcare and reimbursement environments. Furthermore, we are humbled and grateful that Dr. Penner would entrust her life's work to us in revising the fourth edition of Economics and Financial Management for Nurses and Nurse Leaders, so many more generations of nurses may benefit from her wisdom. To honor Dr. Penner, it is with these sentiments in mind that we've renamed the book Penner's Economics and Financial Management for Nurses and Nurse Leaders, Fourth Edition"-- Provided by publisher.

Contents:
Chapter 1. Economics of health care
Chapter 2. Healthcare reimbursement and insurance
Chapter 3. Quantifying nursing care, staffing, and productivity
Chapter 4. Budget planning
Chapter 5. Reporting and managing budgets
Chpater 6. Special purpose, capital, and other budgets
Chapter 7. Cost-benefit analysis
Chapter 8. Assessing financial health
Chapter 9. Building a business case
Chapter 10. Entrepreneurship, contract negotiation, and practice management
Chapter 11. Grant writing for helathcare programs
Chater 12. Ethical issues and financial issues in international healthcare systems
Chapter 13. Health policy and future trends.

Summary: "Compilation of terms, definitions, and discussion from major published psychoanalytic glossaries. In addition to the Language of Psychoanalysis (Laplanche and Pontalis), PEP has integrated three additional glossaries: the Edinburgh International Encyclopaedia of Psychoanalysis (Skelton), Glossary of Psychoanalytic Terms and Concepts (Moore and Fine), and the Dictionary of Kleinian Thought (Hinshelwood). PEP has also integrated the EPF Glossary of Psychoanalysis in Europe (Junkers), which provides a mapping of each psychoanalytic term across several languages."

Contents:
Chapter One. Chemical posttranslational modification with designed rhodium(II) catalysts
Chapter Two. Cell-binding assays for determining the affinity of protein-protein interactions: technologies and considerations
Chapter Three. Protein and antibody engineering by phage display
Chapter Four. Incorporation of unnatural amino acids into proteins expressed in mammalian cells
Chapter Five. Method for enzyme design with genetically encoded unnatural amino acids
Chapter Six. Methods for solving highly symmetric de novo designed metalloproteins: crystallographic examination of a novel three-stranded coiled-coil structure containing D-amino acids
Chapter Seven. SpyRings declassified: a blueprint for using isopeptide-mediated cyclization to enhance enzyme thermal resilience
Chapter Eight. Engineering and application of LOV2-based photoswitches
Chapter Nine. Minimalist design of allosterically regulated protein catalysts
Chapter Ten. Combining design and selection to create novel protein-peptide interactions
Chapter Eleven. Metal-directed design of supramolecular protein assemblies
Chapter Twelve. Designing fluorinated proteins
Chapter Thirteen. Solid phase synthesis of helically folded aromatic oligoamides
Chapter Fourteen. Conformational restriction of peptides using dithiol bis-alkylation
Chapter Fifteen. Engineering short preorganized peptide sequences for metal ion coordination: copper(II) a case study
Chapter Sixteen. De Novo construction of redox active proteins
Chapter Seventeen. Design strategies for redox active metalloenzymes: applications in hydrogen production
Chapter Eighteen. Equilibrium studies of designed metalloproteins
Chapter Nineteen. Reconstitution of heme enzymes with artificial metalloporphyrinoids
Chapter Twenty. Creation of a thermally tolerant peroxidase
Chapter Twenty-One. Designing covalently linked heterodimeric four-helix bundles
Chapter Twenty-Two. Design of heteronuclear metalloenzymes
Chapter Twenty-Three. Periplasmic screening for artifical metalloenzymes
Chapter Twenty-Four. De Novo designed imaging agents based on lanthanide peptides complexes
Chapter Twenty-Five. Peptide binding for bio-based nanomaterials
Author Index
Subject Index.

Contents:
Peptide Antibodies: Past, Present, and Future / Gunnar Houen
Structure of natural and recombinant antibodies / Hui Ma and Richard O'Kennedy
Prediction of antigenic B and T cell epitopes via energy decomposition analysis : description of the web-based prediction tool BEPPE / Claudio Peri ... [et al.]
Prediction of antibody epitopes / Morten Nielsen and Paolo Marcatili
Fmoc solid-phase peptide synthesis / Paul R. Hansen and Alberto Oddo
Peptide-carrier conjugation / Paul R. Hansen
Solid-phase peptide-carrier conjugation / Gunnar Houen and Dorthe T. Olsen
Analysis of peptides and conjugates by amino acid analysis / Peter Højrup
Characterization of synthetic peptides by mass spectrometry / Bala K. Prabhala ... [et al.]
Interpretation of tandem mass spectrometry (MSMS) spectra for peptide analysis / Karin Hjernø and Peter Højrup
Polyclonal Peptide Antisera / Tina H. Pihl, Kristin E. Illigen, and Gunnar Houen
Production and screening of monoclonal peptide antibodies / Nicole Hartwig Trier ... [et al.]
Production of epitope-specific antibodies by immunization with synthetic epitope peptide formulated with CpG-DNA- liposome complex without carriers / Dongbum Kim, Younghee Lee, and Hyung-Joo Kwon
Thioredoxin-displayed multipeptide immunogens / Angelo Bolchi ... [et al.]
Purification of natural and recombinant peptide antibodies by affinity chromatographic strategies / Hui Ma and Richard O'Kennedy
Isolation of camelid single-domain antibodies against native proteins using recombinant multivalent peptide ligands / Norah A. Alturki ... [et al.]
Generation of TCR-Like antibodies using phage display / Brian H. Santich ... [et al.]
Structural characterization of peptide antibodies/ Anna Chailyan and Paolo Marcatili
Automated high-throughput mapping of linear B-cell epitopes using a statistical analysis of high-density peptide microarray data / Thomas Østerbye and Søren Buus
Characterization of peptide antibodies by epitope mapping using resin-bound and soluble peptides / Nicole Hartwig Trier
Screening and characterization of linear B-cell epitopes by biotinylated peptide libraries / Ida Rosenkrands and Anja Olsen
Bead-based peptide arrays for profiling the specificity of modification state-specific antibodies / Angela Filomena ... [et al.]
Surface plasmon resonance method to evaluate anti-citrullinated protein/peptide antibody affinity to citrullinated peptides / Feliciana Real-Fernández ... [et al.]
Specificity analysis of histone modification-specific antibodies or reading domains on histone peptide arrays / Goran Kungulovski ... [et al.]
Prion-specific antibodies produced in wild-type mice / Peter M. H. Heegaard ... [et al.]
Immunoblotting with peptide antibodies : differential immunoreactivities caused by certain amino acid substitutions in a short peptide and possible effects of differential refolding of the peptide on a nitrocellulose or PVDF membrane / Takenori Yamamoto ... [et al.]
Immunocytochemical and immunohistochemical staining with peptide antibodies / Tina Friis ... [et al.]
Designing B-cell epitopes for immunotherapy and subunit vaccines / Harinder Singh ... [et al.]
Enterovirus-specific anti-peptide antibodies / Chit Laa Poh ... [et al.]
Therapeutic HIV peptide vaccine / Anders Fomsgaard.

Contents:
Peptide therapeutics
Methods for the peptide synthesis and analysis
Peptide design strategies for g-protein coupled receptors (GPCRs)
Peptide-based inhibitors of enzymes
Discovery of peptide drugs as enzyme inhibitors and activators
Discovery of peptide drugs from natural sources
Modification of peptides to limit metabolism
Delivery of peptide drugs.

Contents:
Design, synthesis, and application of OB2c combinatorial peptide and peptidomimetic libraries
Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via cuAAC-/hydrazide-mediated cyclization
Synthesis and screening of one-bead-one-compound cyclic peptide libraries
Creating site-specific isopeptide linkages between proteins with the traceless staudinger ligation
Macrocyclic templates for library synthesis of peptido-conjugates
Synthesis and alkylation of aza-gly-pro building blocks of peptidomimetic libraries for developing prostaglandin f2alpha receptor modulators as therapeutics to inhibit preterm labor
A fragment-based selection approach for the discovery of peptide macrocycles targeting protein kinases
Peptide and peptide library cyclization via bromomethylbenzene derivatives
Phage selection of bicyclic peptides based on two disulfide bridges
De novo discovery of bioactive cyclic peptides using bacterial display and flow cytometry
Chemical posttranslational modification of phage-displayed peptides
Mapping protein-protein interactions with phage-displayed combinatorial peptide libraries and alanine scanning
Identifying reactive peptides from phage-displayed libraries
The best and the brightest: Exploiting tryptophan-sensitized tb(3+) luminescence to engineer lanthanide-binding tags
Synthesis and cell-based screening of one-bead-one-compound peptide libraries
Screening peptide array library for the identification of cancer cell-binding peptides
Next-generation sequencing of phage-displayed peptide libraries
Maleimide-based method for elaboration of cysteine-containing peptide phage libraries.

Contents:
Peptide arrays on planar supports / Víctor Tapia Mancilla and Rudolf Volkmer
High-throughput microarray incubations using multi-well chambers / Johannes Zerweck ... [et al.]
Analysis of protein tyrosine kinase specificity using positional scanning peptide microarrays / Yang Deng and Benjamin E. Turk
Secondary structure determination of peptides and proteins after immobilization / Stella H. North and Chris R. Taitt
Peptides and anti-peptide antibodies for small and medium scale peptide and anti-peptide affinity microarrays : antigenic peptide selection, immobilization, and processing / Fan Zhang, Andrea Briones, and Mikhail Soloviev
Low-cost peptide microarrays for mapping continuous antibody epitopes / Ryan McBride ... [et al.]
Peptide microarray-based resonance light scattering assay for sensitively detecting intracellular kinase activity / Tao Li ... [et al.]
Anomalous reflection of gold : a novel platform for biochips / Amir Syahir ... [et al.]
High-throughput peptide screening on a bimodal imprinting chip through MS-SPRi integration / Weizhi Wang, Qiaojun Fang, and Zhiyuan Hu
Analyzing peptide microarray data with the R pepStat package / Gregory Imholte, Renan Sauteraud, and Raphael Gottardo
Chemoselective strategies to peptide and protein bioprobes immobilization on microarray surfaces / Alessandro Gori and Renato Longhi
Manufacturing of peptide microarrays based on catalyst- free click chemistry / Denis Prim and Marc E. Pfeifer
Clickable polymeric coating for oriented peptide immobilization / Laura Sola ... [et al.]
Oriented peptide immobilization on microspheres / Lisa C. Shriver-Lake, George P. Anderson, and Chris R. Taitt
Cell microarray format : a peptide release system using a photo-cleavable linker for cell toxicity and cell Uptake Analysis / Kenji Usui, Kin-ya Tomizaki, and Hisakazu Mihara
Peptide microarrays for medical applications in autoimmunity, infection, and cancer / Carsten Grötzinger
Synthetic peptide-based ELISA and ELISpot assay for identifying autoantibody epitopes / Judit Pozsgay ... [et al.]
IgE and IgG4 epitope mapping of food allergens with a peptide microarray immunoassay / Javier Martínez-Botas and Belén de la Hoz
IgE epitope mapping using peptide microarray immunoassay / Gustavo Gimenez, Sara Benedé, and Jing Lin
Spot synthesis : an optimized microarray to detect IgE epitopes / Salvatore G. De-Simone, Paloma Napoleão-Pêgo, and Thatiane S. De-Simone
Mapping of epitopes occurring in bovine αs1-casein variants by peptide microarray immunoassay / Maria Lisson and Georg Erhardt.

Summary: Exemplifying and illustrating recent exciting advances in PNA chemistry, the second edition of Peptide Nucleic Acids: Methods and Protocols serves as a vital complement to the first edition of the book. Since the discovery of peptide nucleic acids, many interesting new derivatives and analogues in terms of nucleic acid recognition specificity and affinity have emerged. Also, as this detailed volume presents, great ingenuity in exploiting the unique properties of PNAs for a wide variety of applications within drug discovery, medical diagnostics, chemical biology and nanotechnology has unfolded. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Peptide Nucleic Acids: Methods and Protocols, Second Editionserves as a source of useful specific methods and protocols as well as a source of inspiration for future developments.

Contents:
MiniPEG-PNA / Arunava Manna [and others]
Cyclopentane peptide nucleic acids / Ethan A. Englund, Ning Zhang, and Daniel H. Appella
Chiral PNAs with constrained open-chain backbones / Roberto Corradini [and others]
Synthesis, characterization, and evaluation of radiometal-containing peptide nucleic acids / Holger Stephan, Christian Foerster, and Gilles Gasser
Preparation of metal-containing peptide nucleic acid bioconjugates on the solid phase / Gilles Gasser
Formation and characterization of PNA-containing heteroquadruplexes / Bruce A. Armitage
Sequence selective recognition of double-stranded RNA using triple helix-forming peptide nucleic acids / Thomas Zengeya, Pankaj Gupta, and Eriks Rozners
Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates : programming the combinatorial pairing and inter-ligand distance / Nicolas Winssinger [and others]
Site-selective scission of human genome using PNA-based artificial restriction DNA cutter / Kenichiro Ito and Makoto Komiyama
PNA openers and their applications for bacterial DNA diagnostics / Irina V. Smolina and Maxim D. Frank-Kamenetskii
DNA-Templated Native chemical ligation of functionalized peptide nucleic acids : a versatile tool for single base-specific detection of nucleic acids / Alexander Roloff [and others]
Use of peptide nucleic acids (PNAs) for genotyping by solution and surface methods / Stefano Sforza [and others]
Analysis of PNA Hybridization by surface plasmon resonance / Bruce A. Armitage
PNA fluorescent in situ hybridization (FISH) for rapid microbiology and cytogenetic analysis / Henrik Stender, Brett Williams, and James Coull
Rapid miRNA imaging in cells using fluorogenic templated staudinger reaction between PNA-based probes / Katarzyna Gorska and Nicolas Winssinger
Cellular delivery of peptide nucleic acids (PNAs) / Takehiko Shiraishi and Peter E. Nielsen
Peptide nucleic acid-mediated recombination for targeted genomic repair and modification / Erica B. Schleifman and Peter M. Glazer
Antisense effects of PNAs in bacteria / Shan Goh, Jem Stach, and Liam Good.

Contents:
1. Programmable bio-surfaces for biomedical applications
2. Solid-binding peptides in biomedicine
3. Molecular modelling of peptide-based materials for biomedical applications
4. Design principles of peptide based self-assembled nanomaterials
5. Bioprinting and biofabrication with peptide and protein biomaterials
6. Peptides as bio-inspired molecular electronic materials
7. Peptide-based materials for cartilage tissue regeneration
8. Peptides and drug delivery
9. Peptide lipidation-- a synthetic strategy to afford peptide based therapeutics
10. Molecular engineering of Conus peptides as therapeutic leads
11. Uptake mechanism of cell-penetrating peptides
12. Empowering the potential of cell-penetrating peptides for targeted intracellular delivery via molecular self-assembly
13. The current role of cell-penetrating peptides in cancer therapy
Index.

Summary: This book provides an extensive discussion of echocardiography-guided percutaneous interventional techniques for clinical practitioners, including cardiologists, interventional physicians, surgeons and specialist training candidates. It allows readers to gain a thorough understanding of interpreting echocardiography-guided procedures, which not only protect patients from pain and other complications associated with conventional surgery, but also obviate the use of fluoroscopy or contrast agents and so avoid radiation damage and the risks of allergy or renal function impairment. Further, these procedures could help to save patients in areas lacking medical resources. The book first demonstrates the substitution of transesophageal for transthoracic echocardiography to avoid intubation under general anesthesia, and then presents key technical and practical aspects of echo-guided percutaneous interventions for structural heart diseases, such as ASD, VSD, PDA, PS, MS, AS and CoA. Lastly, it explores the lessons learned in echocardiography, anesthesia and postprocedural management of echo-guided percutaneous interventions.

Contents:
Introduction
Anesthesia Management in Echocardiography-guided Percutaneous Interventions for Structural Heart Disease
Use of Echocardiography in Percutaneous Interventions for Structural Heart Disease
Echocardiography-guided Interventional Atrial Septal Defect Closure
Echocardiography-guided Interventional for Pulmonary Stenosis
Echocardiography-guided Interventional Patent Ductus Arteriosus Closure
Echocardiography-guided Interventional Closure of Perimembranous Ventricular Septal Defect
Echocardiography-guided Interventional Left Atrial Appendage Closure
Echocardiography-guided Percutaneous Interventional for Mitral Valve Stenosis
Echocardiography-guided Percutaneous Interventional for Aortic Valve Stenosis
Echocardiography-guided Percutaneous Interventional for Coarctation of Aorta
Post-procedural Management of Echocardiography-guided Percutaneous Interventions.

Summary: Percutaneous Collagen Induction with Microneedling is a minimally invasive technique widely used to treat numerous dermatologic conditions such as facial and body scars, melasma, wrinkles, skin laxity, stretch marks, alopecies, vitiligo and scleroderma. Microneedling can also be used to optimize transdermal drug delivery for many substances. This technique uses modern microneedling devices containing multiple fine needles, typically 0.5 to 2.5 mm in length, which are mounted on a barrel and rolled onto the skin to create numerous perforations into the stratum corneum and the papillary dermis. These micro-wounds initiate the release of growth factors, triggering collagen and elastin formation, which results in dermal remodeling and skin resurfacing. This book provides a step-by-step approach to microneedling, based on the authors' more than ten years of experience with the technique, during which they have treated more than 3,000 patients in Brazil for numerous dermatologic conditions. Richly illustrated throughout, it includes over 400 illustrations.

Contents:
Intro
Presentation
Acknowledgments
Contents
About the Authors
Chapter 1: Fundamentals of Percutaneous Collagen Induction (PCI) with Needles
1.1 Percutaneous Needle Collagen Induction (PCI) Versus Ablative Procedures
1.2 Principles of the PCI Technique
1.3 Characteristics of the PCI Technique
1.4 PCI Advantages
1.5 Disadvantages of PCI
Sources
Chapter 2: Classification and Characteristics of the Injury Provoked by PCI
2.1 Level of the Injury and Its Relationship to the Length of the Needle
2.2 Classification of Injury Level
2.3 Final Considerations 4.2.10 Peripheral Nerve Blocks
4.2.11 Blocking the Supraorbital and Supratrochlear Nerves
4.2.12 Infraorbital Nerve Block
4.2.13 Nasociliary Nerve Block
4.2.14 Lacrimal Nerve Block
4.2.15 Zygomatic Nerve Block
4.2.16 Mental Nerve Block
4.3 Local Anesthetic Intoxication
4.3.1 Special Features of Anesthesia for PCI
Sources
Chapter 5: Preparing the Skin for PCI and Postoperative Management
5.1 Skin Care That Favors Treatment
5.2 Detailing the Guidelines for Moderate Injury
5.3 Detail of the Guidelines for Deep Lesion
5.4 Biocellulose in Post-procedure 5.5 Closing Considerations
Sources
Chapter 6: Histopathological Evidences of the Percutaneous Collagen Induction with Microneedling
6.1 Introduction
6.2 Photoaging and Melasma
6.3 Acne and Stretch Mark Scars
Sources
Chapter 7: Managing Complications in PCI
7.1 PCI Versus Ablative Interventions
7.2 Expected Reactions and Adverse Effects
7.2.1 Edema
7.2.2 Erythema
7.2.3 Hematoma, Petechiae, and Purple
7.2.4 Crusts
7.2.5 Post-inflammatory Hyperpigmentation
7.2.6 Desquamation
7.2.7 Burning and Awareness
7.2.8 Infections
7.2.9 Pain 7.2.10 Depressed or Elevated Scars
Sources
Chapter 8: PCI in Aging Skin
8.1 PCI Fundamentals in Skin Aging
8.2 Applicability of PCI to Skin Aging
8.3 Thickness of Skin
8.4 Wrinkle Depth
8.5 Flaccidity
8.6 Step-by-Step
8.6.1 Deep Injury
8.7 Methodological Sequence for Deep Injury
8.7.1 Moderate Injury
8.8 Final Considerations
Sources
Chapter 9: PCI in the Treatment of Melasma
9.1 Lima Protocol
9.2 Mechanism of Action
9.2.1 Proposed Methodological Sequence
9.3 Final Considerations
Sources

Summary: The second edition of this essential text provides readers with a detailed guide to performing various percutaneous coronary intervention (PCI) techniques for treating coronary chronic total occlusion (CTO). PCI continues to be an effective procedure to help patients with this pathology, with high success and low complications rates. Chapters feature a step-by-step approach to relevant techniques and describe their potential pitfalls, enabling the reader to develop a thorough understanding of how to perform those procedures successfully. Details of the latest methods for angiography analysis and the management of ostial CTOs, plus heavily revised chapters on topics such as contemporary device-based antegrade dissection and the retrograde approach through septal and non-septal collateral channels ensure that this Work remains the most up-to-date reference on the subject. Percutaneous Intervention for Coronary Chronic Total Occlusion: The Hybrid Approach represents a vital reference to assist practicing and trainee interventional cardiologist in learning these techniques. Various examples are provided, with a vast selection of still images and angiographic video loops to enable the reader become confident in applying these methodologies into their day-to day clinical practice.

Contents:
Intro
Foreword
Preface of the First edition
Preface of the Second edition
Contents
About the Editor
1: What Is What: Important Definitions in Chronic Total Occlusion Percutaneous Coronary Intervention
Introduction
Anatomical and Procedural Definitions
Efficacy and Safety Endpoints
Conclusion
References
2: The Histopathophysiology of Chronic Total Occlusion and Its Impact on Mode of Treatment
Introduction
Mechanisms of Lesion Progression and Histologic Studies of CTO
Characteristics of the Arterial Wall
The Lesion Characteristics of CTO With or Without Prior CABG
Clinical Translation from a Pathological Point of View
Conclusions
References
3: Who Are Best Candidates for Chronic Total Occlusion Revascularization
Introduction
Prior Evidence
EXPLORE Trial
REVASC Trial
EUROCTO Trial
DECISION-CTO Trial
Conclusions from Trials
Which Patients Are Best Candidates?
Final Remarks
Conclusions
References
4: Why, When and How to Assess Ischemia and Viability in Patients with Chronic Total Occlusions
Introduction
Ischemia, Hibernation, and Viability
Why to Assess Ischemia and Viability?
Ischemia
Ischemia and Collaterals, and After Opening the CTO
Ischemia and Prognosis
Ischemia and Symptoms
Viability
When to Assess Ischemia and Viability?
Guideline Recommendations
STEMI Patients with a CTO
Stable Patients with a CTO
Case Examples
How to Assess Ischemia and Viability?
Ischemia
Nuclear Myocardial Perfusion Imaging
Stress Echocardiography
Stress Cardiac Magnetic Resonance Imaging
Viability
Stress Echocardiography
Cardiac Magnetic Resonance Imaging
Nuclear Imaging
Conclusion
References
5: How to Set Up a Chronic Total Occlusion Angioplasty Program
Introduction
Developing CTO Skills. Operator Selection
Operator Training
CTO Program Built Around Two Operators
Infrastructure
Cardiac Catheterization Laboratory Volume
Cardiac Catheterization Laboratory
Cardiac Surgery Program/Extracorporeal Membrane Oxygenation (ECMO)
Nonmedical Staff
Administrative Support
Quality Control
Pre-procedure: CTO Clinic
Pre-PCI Explanation of the Plan
Post Procedure: CTO Rounds
Getting Started, the Practicalities
References
6: Equipment Requirement for Chronic Total Occlusion Percutaneous Coronary Intervention
Sheaths
Guide Catheters
Microcatheters
Finecross
Corsair Series
Turnpike Series
Mamba Series
Guidewires
Dissection/Reentry Equipment
Guide Catheter Extensions
Snares
Equipment for "Uncrossable-Undilatable" Lesions
Intravascular Ultrasound (IVUS)
Complication Management Equipment
References
7: The Hybrid Approach and Its Variations for Chronic Total Occlusion Percutaneous Coronary Intervention
Introduction and Historical Perspective
Simplifying the Complex
The Algorithms.... Combined
Who Should Do the Procedure?
Pre-procedure Coronary CT Angiography
Choosing the Initial Strategy
Antegrade Wiring
Secondary and Bailout Strategies with Primary AW Approach
Antegrade Dissection and Reentry (ADR)
The Retrograde Approach
In-Stent Chronic Total Occlusion
Switching Strategies
Ending the Procedure
Conclusions
References
8: When, Why, and How to Perform Good Angiographic Analysis Before CTO PCI
Introduction
When and Why
How
CTO Angiography
CTO Angiographic Analysis
Target Vessel
CTO Characteristics
Donor Vessels
Collateral Circulation
Collateral Pathways
Interventional Collaterals
Conclusion
References
9: Specific Basic Techniques to Master in CTO PCI
Approaching the CTO Segment. Wire Manipulation Techniques in CTO
Trapping Balloon Technique
References
10: When, Why and How to Perform an Antegrade Approach Using a Wiring Technique
Introduction
Anatomical Subsets That Favor Antegrade Wiring
Lesion Length
Proximal Cap Anatomy
In-CTO Tortuosity (&gt
45°)
Presence of Intra-CTO Calcium
Previous Procedural Failure
Other Factors
Degree of Disease in the "Distal Landing Zone"
Presence of "Interventional Collaterals"
Basic Principles of CTO PCI
Planning
Visibility
Backup Support
Use of "Over-the-Wire" Equipment
Wire Selection
Tapered Polymer-Coated Wires
Medium Weight Wires
High Gram Weight Wires
The Proximal Cap and How to Assess It
Wire Selection: Principles and Rationale
Polymer-Coated Wires
Penetration Force
Tactile Feel
Torque Transmission
Wire Selection
Wire Shaping
Confirming Progress and Ensuring Safety
Confirming True Lumen Entry
Angiographically
Wire Feel
Intravascular Ultrasound (IVUS)
Advancing Equipment
Anchor Balloon
Guide Extension
Higher Support Microcatheter
Laser Atherectomy
Rotational Atherectomy
Indications and Use of Adjunctive Imaging Strategies
CTA
IVUS
When to Switch Strategy
References
11: When, Why, and How to Perform Wire-Based Antegrade Dissection and Reentry Technique
References
12: When and How to Perform Contemporary Device-Based Antegrade Dissection and Re-entry Technique
Introduction
Evolution of Strategies for ADR
Primary ADR: A Step-by-Step Approach
Troubleshooting ADR Procedures and Bailout Manoeuvres
Outcomes with ADR in Contemporary Practice
Conclusions
References
13: How to Deal with Difficult Antegrade Issues
Difficult Antegrade Issues That Apply to Both AW and ADR
Ambiguous Proximal Cap
Impenetrable Cap. Uncrossable Lesion
Difficult Antegrade Issues That Are Unique to Antegrade Dissection Reentry
Crossboss Challenges
Reentry Challenges
References
14: Intra-occlusion Microinjection of Contrast: When, Why, and How
References
15: When, Why, and How to Perform the Antegrade Fenestration and Reentry Technique
Introduction
Pathophysiological Bases and Development of Antegrade Fenestration and Reentry (AFR)
Procedural Description of Antegrade Fenestration and Reentry (AFR)
Real-Life Experience with Antegrade Fenestration and Reentry (AFR)
Role of Antegrade Fenestration and Reentry (AFR) in the Hybrid Algorithm
Further Developments in Antegrade Fenestration and Reentry (AFR)
Conclusions
References
16: When, Why, and How to Perform the Retrograde Approach Through Septal Collateral Channels
When to Select the Retrograde Approach: How to Analyze the Coronary Angiography
How to Set Up the Procedure
Pathways to the Distal Cap (Table 16.1)
Collateral Channels
Step-by-Step Approach
Selecting the Microcatheter, Crossing the Collateral Channel with a Wire, and the Microcatheter
Selecting the Microcatheter
Crossing a Septal CC with the Wire
Surfing from PDA to LAD: A More Difficult Task
Advancing the Microcatheter to the Distal Cap Through the Septal CC
Special Situations and Considerations
Using an Internal Mammary Artery as a Donor Artery to Septal CCs
LAD or LCX CTOs in a Dominant Left System
References
17: When, Why, and How to Perform the Retrograde Approach Through Epicardial and Non-septal Collateral Channels
When to Perform Retrograde CTO PCI Via Non-septal Connections? Anatomic Evaluation
Algorithms for Performing Retrograde Approach
Collateral Channel Scores
Why Performing Retrograde CTO PCI Via Non-septal CCs? Clinical Evaluation. Indication and Timing of Using Non-septal Collateral CCs
Risk-Benefit Assessment of Selecting Non-septal CCs
How to Perform Retrograde CTO PCI Via Non-septal Connections: Practical Considerations
Arterial Access
Non-septal Collateral Channel Crossing
Crossing the CTO
Externalization
Complications Related to Retrograde CTO PCI Via Non-septal Connections
Perforation of the CC When the CTO Is Crossed
Perforation of the CC When the CTO Remains Uncrossed
References
18: When, Why, and How to Perform the Retrograde Approach Through Patent or Occluded SVGs
Introduction
CTO PCI in Post-CABG Patients
Retrograde Approach Through an SVG
Retrograde Via Diseased But Patent SVGs
Retrograde Via Occluded SVGs
Guide Extensions in SVGs
Specific Situations
Stumpless SVG Use
Retrograde Access Via Acutely or Recently Thrombosed SVG in ACS Patients
How to Deal with Acute Angle of Distal Anastomosis
Distal Anastomosis Ambiguity
Stenting Coronary Across Distal SVG Anastomosis After CTO PCI
Dealing with Anastomotic Stents in SVGs
Protecting the Graft
What To Do with the SVG Once the Native Artery CTO is Open?
Potential Complications When Using SVGs as Retrograde Conduits
Distal Embolization
SVG Perforation
Aortic Dissection
Mediastinal Bleeding/Haematoma
References
19: How to Cross the Occlusion Using a Retrograde Approach, How to Externalize, and How to Snare Long Wires
Introduction
Retrograde Wiring
Wire Choice
Confirming Wire Position
Note on Safety in RW
Retrograde Dissection and Re-entry
Creating an Antegrade Dissection
Use of Guide Catheter Extension
Creating a Retrograde Dissection
Joining the Spaces
Externalization
Use of Snare for Externalization
Principles of Snaring
How to Snare.

Summary: This book provides a comprehensive source for all aspects of percutaneous image-guided biopsy. A synthesis of rationale, technique and evidence-based medicine, it offers a clear approach to imaging, devices, procedures and patient care.

Contents:
Biopsy devices and techniques
CT-guided biopsy
Radiation protection during CT-guided interventions
Ultrasound-guided biopsy
MRI-guided biopsy
Fluoroscopy-guided biopsy
Advanced tools and devices: navigation technologies, automation, and robotics in percutaneous interventions
Pathologic evalution of tissues obtained by interventional radiology techniques
Biopsy of head and neck lesions
Biopsy of mediastinal lesions
Percutaneous transthoracic lung biopsy
Pleural biopsy
Liver biopsy
Percutaneous biopsy of the pancreas
Spleen biopsy
Adrenal gland biopsy
Renal mass biopsy
Percutaneous and transjugular kidney biopsy
Nodes and soft tissue masses involving the retroperitoneum, mesentery, omentum and peritoneal ligaments
Biopsy of pelvic lesions
MRI-guided prostate biopsy
Biopsy of the spine
Anatomic guidelines and approaches for biopsy of the long bones
Musculoskeletal biopsies: extremities.

Contents:
1. How to justify CTO revascularization
2. How to set up a chronic total occlusion angioplasty program
3. What equipment should be available?
4. Specific basic techniques to master in CTO PCI
5. When and how to perform an antegrade approach using a wire escalation technique
6. When and how to perform an antegrade dissection/re-entry approach using the CrossBoss and Singray Catheters
7. How to deal with difficult antegrade issues
8. Intra-occlusion microinjectin of contrast: when, why and how
9. How and when to perform the retrograde approach
10. How to recanalize in-stent chronic total occlusion
11. How to fix common problems encountered in CTO PCI: the expanded hybrid approach
12. How to improve catheter support during CTO PCI
13. When and how to perform a transradial appraoch for CTO PCI
14. How to manage radiation and contrast during chronic total occlusion percutaneous coronary intervention
15. Complications of chronic total occlusion percutaneous coronary intervention
16. How to prevent perforation during CTO PCI
17. How to prevent and manage ischemic complications during CTO PCI
18. Managing entrapped gear during chronic total occlusion interventions
19. How to start and build your CTO practice and maintain referrals in a competitive environment
Index.

Contents:
NANOCARRIERS IN PENETRATION ENHANCEMENT
Role Of Nanotechnology In Skin Delivery Of Drugs
LIPID-BASED VESICLES
Liposomes As Drug Delivery Systems In Dermal/Transdermal Drug Delivery (From The Beginning)
Transfersomes For Enhanced Skin Permeation Of Drugs
Mechanism Of Penetration Enhancement Of Ultra deformable Vesicles
Enhanced Skin Permeation Using Ethosomes
Invasomes-Vesicles For Enhanced Skin Delivery Of Drugs
Penetration-Enhancer-Containing Vesicles For Cutaneous Drug Delivery
Stratum Corneum Lipid Liposomes
Vesosomes
Surface-Charged Vesicles For Penetration Enhancement
SURFACTANT-BASED VESICLES
Niosomes And Pro-Niosomes For Enhanced Skin Delivery
Novasomes For Enhanced Skin Delivery
LIPID-BASED ICULATE CARRIERS (OR ICLES)
Solid Lipid Nanoicles, Nano structured Lipid Carriers And Lipid Nano capsules For Topical Delivery
POLYMER-BASED NANOCARRIERS (ICULATE CARRIERS) IN PENETRATION ENHANCEMENT
Polymeric Nano (And Micro-) Particles As Carriers For Enhanced Skin Penetration (General)
Polymeric Nanocapsules For Cutaneous Application
Polymeric Micelles In Dermal/Transdermal Drug Delivery
Dendrimers In Enhancing Skin Penetration
Dendritic Core-Multishell (CMS) Nanotransporters For Skin Delivery
NANOCRYSTALS IN PENETRATION ENHANCEMENT
Nanocrystals For Enhanced Skin Delivery Of Drugs.

Summary: Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.

Contents:
Section 1. Introduction
section 2. Percutaneous management of large renal calculi (Percutaneous Nephrolithotomy)
section 3. Percutaneous management of transitional cell cancer (Percutaneous resection of tumor)
section 4. Percutaneous ablation of renal cell cancer (Thermal and nonthermal).

Contents:
Foreword
Anatomy
Equipment, Instruments, and Personnel
Indications for PCNL-Patient Selection and Evaluation
Percutaneous Nephrostomy
Routine Percutaneous Nephrolithotomy and Pyeloplasty
Complex Punctures
Complications of PCNL and their Management
Critical Pathways, Theatre Equipment Lists and Setups
PCNL Workshop.

Contents:
1. Tracheostomy: from surgical to percutaneous techniques
2. Anatomiical and sonographic landmark
3. Indication and timing
4. Surgical tracheostomy
5. Percutaneous tracheostomy: the ciaglia techniques
6. Balloon dilation tracheostomy
7. Percutaneous tracheostomy: the guide wire dilating forceps technique
8. Frova's rotational technique and Fantoni's translaryngeal tracheostomy
9. Choice of the appropriate tracheostomy technique
10. Complications of percutaneous and surgical tracheostomy in critically ill patients
11. Emergency percutaneous tracheotomy
12. Tracheostomy tube types and criteria of choice
13. Airway managment during tracheostomy: conventional device, laryngeal mask airway, double lumen endotracheal tube
14. Medical and nursing management of tracheostomy
15 .Quality of life and complications after percutaneous tracheostomy
16. Clinical practice of informed consent for percutaneous tracheostomy
17. Tracheostomy in intensive care unit: the need of European guidelines.

Contents:
1. Women and invasive diagnostic procedures
2. Intracoronary imaging and intracoronary functional tests
3. Interventional treatment of stable coronary artery disease in women
4. Interventional treatment of Acute Coronary Syndrome (ACS): non-ST-elevation ACS (NSTE-ACS)
5. Interventional treatment of acute coronary syndrome: ST-segment elevation myocardial infarction
6. Peri- and Post-procedural Antithrombotic Therapy in Women
7. Aortic valve valvuloplasty
8. Transcatheter aortic valve implantation
9. Mitral valvuloplasty for mitral stenosis
10. Treatment of mitral regurgitation
11. Surgical and percutaneous treatment of tricuspid valve
12. Left atrial appendage closure
13. Closure of atrial septal defect and patent foramen ovale
14. Ablation of atrial fibrillation in women
15. Biventricular pacing in women for heart failure
16. Thoracic and abdominal aorta percutaneous treatment
17. Treatment of peripheral arteriopathy in women
18. Gender Differences in Carotid Artery Stenting
19. Percutaneous treatment during pregnancy
20. Left ventricular assist devices.

Summary: For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been a reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline's "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.

Contents:
Sect. I: Overview and basic science of radiation oncology
Pt. A: Cancer biology
Pt. B: Medical radiation physics
Sect. II: Techniques, modalities, and modifiers in radiation oncology
Sect. III: Clinical radiation oncology Pt. A: Skin
Pt. B: Central nervous system
Pt. C: Head and neck
Pt. D: Thorax
Pt. E: Breast
Pt. F: Gastrointestinal
Pt. G: Urinary tract
Pt. H: Male genitourinary
Pt. I: Gynecologic
Pt. J: Adrenal and retroperitoneal tumors
Pt. K: Lymphoma and hematologic tumors
Pt. L: Bone and soft tissue
Pt. M: Pediatric
Pt. N: Benign diseases
Sect. IV: Palliative and supportive care
Sect. V: Economics, education, ethics, and technology assessment.

Summary: Sleeve gastrectomy (SG) is the most common bariatric procedure, accounting for more than 55% of all such surgeries performed worldwide. Obesity has become a major global problem that continues to spread in both developed and developing countries. While prevention of obesity is the best approach for the future, the current challenge is managing those who are already obese or morbidly obese, who constitute close to two thirds of the population in many countries, such as the US. Today, bariatric surgery is the only evidence-based treatment for morbid obesity with a low complication rate and acceptable results in the long-term for both weight loss and resolution of comorbidities. This book details all the approaches used in sleeve gastrectomy (SG), offering readers the tools needed to perform the perfect SG. Each chapter focuses on the clinical problems and the indications for the sleeve, and describes the technique step-by-step (including videos), the staplers, the different sizes of bougies, reinforcement of the sutures after the sleeve and the metabolic effects of surgery. The book also presents nontraditional SG techniques, such as the endoscopic approach, stapled sleeve and robotic technologies, discussing how to immediately identify complications and their treatment using endoscopy, laparoscopy and percutaneous image guided surgery. Further, it includes a chapter on revision surgery and revision procedures, not only from sleeve to other procedures, but also from other procedures to SG. The last section offers an overview of what the authors imagine the future holds for this bariatric procedure. The Perfect Sleeve Gastrectomy - A Clinical Guide to Evaluation, Treatment, and Techniques is an ideal reference resource for general surgeons, bariatric surgeons, endoscopists and gastroenterologists as well as researchers with an interest in obesity and its management. It also appeals to residents and fellows, dietitians, diabetes specialist, psychotherapists and hospital administrators and quality officers.

Contents:
Part 1: Operative preparation and background
Part 2: Technical aspects
Part 3: Sleeve gastrectomy GERD and hiatal hernia
Part 4: Nontraditional sleeve gastrectomy
Part 5: Treatment of complications
Part 6: Revisional Surgery
Part 7: Education and future. .

Summary: Nearly two decades ago, the first edition of Perforator Flaps: Anatomy, Technique, & Clinical Applications was published, thereby filling a gap in the literature, and providing invaluable clinical pearls on the use of soft tissue flaps for reconstructive surgery. Since the publication of the second edition, technological advances including MRI angiography, standard color duplex ultrasound, ultra-high frequency ultrasound, and indocyanine green enabled better understanding of select pertinent physiology and delineation of perforators anywhere in the body. Greater anatomical knowledge and the ability to map the course of individual perforators is reflected in the updated third edition by renowned global experts and editors of the prior editions, Phillip N. Blondeel, Steven F. Morris, Geoffrey G. Hallock, and Peter C. Neligan. The primary goal of the third edition is to discuss evidenced-based perforator concepts and techniques that have been incorporated into global practice worldwide. Although condensed into a single volume, the new edition follows a similar format as prior editions, with chapters divided into four sections. The first section provides a solid foundation of knowledge with discussion of rudimentary fundamentals. The second section illustrates the use of basic types of local perforator flaps; introduces the vascularized dermal graft; describes routine suprafascial flap dissections with perforators themselves as recipient and donor vessels; lymphatics reconstituted in concert with perforator flaps; and how to minimize donor site morbidity with "kiss" flaps. The third section outlines basic anatomy and techniques for common perforator flaps, while the fourth section provides a brief overview of suggested preferences for clinical applications, with both sections organized by body region.-- Provided by publisher.

Contents:
The history of the use of perforator flaps for microsurgical breast reconstruction / Sarah E. Appleton and Steven F. Morris
Starting a perforator flap breast program / Christina R. Vargas and Bernard T. Lee
Essential equipment needed for perforator flap breast reconstruction and
Operating room setup / David Greenspun
Deep inferior epigastric perforator flap for breast reconstruction / Robert J. Allen, Sr., Constance M. Chen, and Maria M. Lotempio
Superficial inferior epigastric artery flap for breast reconstruction / Aldona J. Spiegel
Gluteal artery perforator flap for breast reconstruction / Richard Mahlon Kline, Jr., and James Ernest Craigie
Profunda artery perforator flap for breast reconstruction / Robert J. Allen, Sr., Maria M. Lotempio, and Constance M. Chen
Free lumbar artery perforator flap for autologous breast reconstruction / Koen Van Landuyt and Steven F. Morris
Pedicled lateral thoracic flap for breast reconstruction / Moustapha Hamdi and Assaf Zeltzer
Bipedicled (double or stacked) abdominal perforator flap in unilateral breast
Reconstruction / Julie V. Vasile and Joshua L. Levine
Venus salvage procedures in the deep inferior epigastric perforator flap for
Breast reconstruction / Thomas Constantinescu and Ming-Huei Cheng
Imaging for perforator flap breast reconstruction / Julie V. Vasile
Lateral thigh perforator flap (septocutaneous tensor fasciae latae flap) / Stephania Tuinder, Arno Lataster, and Rene Remmelt Willie Johan van der Hulst
Stacked diep/pap flap breast reconstruction / James L. Mayo and Robert J. Allen, Sr
Deep circumflex iliac artery perforator flap for breast reconstruction / Edward Buchel
Indocyanine green/spy imaging in perforator flap breast reconstruction / Michael R. Zenn.

Contents:
1. Expert Care of the Performing Artist
2. Musical Instruments and their Demands on the Body
3. Styles of Dance and Their Demands on the Body
4. The Voice and the Musculoskeletal System
5. Principles of Management
6. Illustrative Musical Case Studies
7. Illustrative Dance Case Studies
8. Overuse Syndromes
9. Hypermobility in Dance; Asset not Liability
10. Scoliosis in Musicians and Dancers
11. Drugs and Therapeutics
12. The Disabled Performer
13. The Multi-Talented Performer
14. Future Trends.

Summary: This book is a monography about perfusion cell cultures for the production of biopharmaceuticals, such as therapeutic proteins (i.e. biomolecules like monoclonal antibodies), and describes the fundamentals, design and operation of these processes. Context is given in the first chapters to understand the state-of-the-art of the technology. We then give an overview of the challenges and objectives in operating mammalian cell perfusion cultures and provide guidelines for the design and setup of lab-scale bioreactor systems, and the required control structure to achieve stable operation. Scale-down devices and PAT tools are described in the context of continuous manufacturing and guidelines for process optimization are given using a variety of case studies to illustrate different approaches. Scale-up is also adressed with a strong focus on bioreactor aeration and mixing, shear stress and cell retention device. Finally, a general introduction for the application of mechanistic and statistic models in bioreactor process development and optimization is given in the last chapter. Provided by publisher.

Contents:
Perfusion mammalian cell culture for recombinant protein manufacturing
Perfusion bioreactors : the set up and process characterization
Scale-down models and sensors for process development
Design and optimization of mammalian cell perfusion cultures
Clinical and commercial scale reactors
Mechanistic and statistical modeling of bioprocesses.

Contents:
Equipment for bypass
Priming the bypass circuit
The bypass plan
Typical phases of cardiopulmonary bypass
Additional notes based on bypass tasks
Bypass considerations based on diagnosis
Notes on select issues during bypass
Notes on select emergency procedures during bypass
Brief overview of named procedures and terms
Abbreviations for congenital heart surgery.

Summary: This book is an up-to-date reference that provides detailed guidance on how to diagnose and manage the soft and hard tissue complications that may be associated with a functioning dental implant placement, such as peri-implant mucositis, soft tissue loss, and peri-implantitis. Treatment options for each complication are described and illustrated step by step and carefully selected cases are presented to further explain the individual stages in management and to highlight key learning points. Practical advice is offered on all aspects of diagnosis, and information is also presented on the definition and etiology of the various complications. The book is in an easy-to-read format and includes a review of the latest literature on the topic.

Contents:
An introduction to understanding the basics of teeth vs. dental implants : similarities and differences
Peri-implant soft tissue deficiencies
Peri-implant mucositis
Hard tissue complications/peri-implantitis.

Summary: The book covers all aspects of peri-operative anesthetic management of liver transplant patients. It provides a comprehensive coverage of the relevant history, surgeons, hepatologists, intensivists and pediatricians perspective of the disease, its pathogenesis, clinical presentation and indication for transplant. It discusses the practical aspects like fluid management and use of vasopressors. The book is divided into sections for a better and comprehensive delivery of information. Individual sections provide up to date information on the pre-operative issues and optimisation, intra-operative care and management and post-operative critical care issues and management of all transplant patients with special emphasis on recent advances. Separate sections cover ICU care of these patients in great detail and anesthetic management of pediatric liver transplant. The book includes anesthetic techniques involved in conducting multiorgan transplant. It discusses clinical approach to a patient with acute liver failure, brain death criteria and laws and organ donor management. It also presents newer techniques and methodologies adopted in the field of liver transplant. It includes ample illustrations, flowcharts, key points in each chapter, figures and photographs. The book contains chapters focusing on post-transplant patients presenting for non-transplant surgery. The book fills the gap in the literature for a comprehensive guide for the anesthetist performing or pursuing liver transplant, students/trainees/examinees who have a keen interest in this field and doctors dealing with such patients in critical care, donor management, pursuing general anesthesia. It is also helpful for hepatologists, intensivists and surgeons associated with liver transplant.

Contents:
Intro
Preface
Contents
About the Editors
1: The History of Liver Transplantation in India
1.1 Introduction
1.2 Background
1.3 Step I: Public Education
1.4 Step 2: Changing the Law
1.5 Step 3: The Initial Procedures
1.6 Step 4: Sustainable Programmes
1.6.1 Numbers
1.6.2 Statewise Distribution
1.6.3 The Situation in 2020
1.7 India Vs the World
1.8 Concerns
1.9 Recommendations
1.10 Conclusions
Part I: Basics Anatomy and Pathophysiology of Liver Disease
2: Physiological Role of Liver and Interpreting Liver Function Tests 2.1 Gross Anatomy of the Liver
2.1.1 Hepatic Blood Flow Regulation
2.2 Cellular Anatomy of the Liver
2.2.1 Models of Liver Microanatomy
2.3 Liver, the Immunological Gateway
2.3.1 Innate and Adaptive Immunity
2.3.2 Immune Tolerance
2.4 Hepatic Drug Metabolism
2.4.1 First Pass Effect
2.4.2 Phases of Drug Metabolism
2.4.3 Drug Extraction Ratio
2.5 Energy Metabolism
2.5.1 Glucose Homeostasis
2.5.2 Nitrogen Metabolism
2.5.3 Fatty Acid Metabolism
2.6 Role of the Liver in Coagulation
2.7 Hepatic Endocrine Function 2.8 Chronic Liver Disease
2.9 Interpreting Liver Function Tests
2.10 Tests Detecting Hepatocyte Injury
2.10.1 Serum Aminotransferases
2.10.2 AST to ALT Ratio
2.10.3 Lactate Dehydrogenase
2.11 Tests Detecting Injury to Bile Ducts
2.11.1 Alkaline Phosphatase
2.12 5′-Nucleotidase
2.13 Gamma-Glutamyl Transferase
2.14 Tests Assessing Biliary Organic Anion Transport
2.14.1 Serum Bilirubin
2.15 Tests Measure Hepatic Synthetic Capacity
2.15.1 Serum Proteins
2.16 Prothrombin Time and International Normalized Ratio 2.17 Tests Measuring Blood Flow and Metabolic Capacity of Liver
2.18 Pattern of Liver Test Abnormalities
2.19 Monitoring Liver Transplant
References
3: Surgical Anatomy of the Liver
3.1 Introduction
3.2 Ligaments of the Liver (Fig. 3.1)
3.2.1 Ligamentum Venosum (Arantius Ligament)
3.3 Lobar and Segmental Anatomy of the Liver
3.3.1 Functional Surgical Anatomy of the Liver
3.3.2 Bismuth's Liver Segmentation
3.4 Caudate Lobe
3.4.1 Hepatocaval Ligament (Makuuchi Ligament)
3.4.2 Riedel Lobe (Fig. 3.8)
3.5 Hepatic Veins (Venous Outflow) 3.5.1 Right Inferior Hepatic Veins: RIHV (Fig. 3.11)
3.5.2 Inferior Phrenic Veins
3.6 Anatomical Relations Around the Hilum
3.6.1 Extrahepatic and Intrahepatic Vasculature
3.7 Portal Vein
3.8 Hepatic Artery
3.9 Biliary Anatomy
3.9.1 Intrahepatic Bile Duct Anatomy
3.9.2 The Right Hepatic Duct
3.9.3 The Left Hepatic Duct
3.9.4 Extrahepatic Biliary Anatomy
3.9.5 Biliary Ductal Anomalies
3.9.6 Bile Duct Blood Supply
3.10 Gallbladder and Cystic Duct
3.10.1 The Calot's Triangle (Fig. 3.19)
References

Summary: PeriAnesthesia Nursing Care: A Bedside Guide for Safe Recovery is a key reference for clinicians practicing in preoperative areas, phase I and phase II PACU nursing areas, and nurses working in critical care, OB, and other specialty recovery units. Ideal for perianesthesia nursing orientation and perioperative cross-training programs, this text is beneficial for all those caring for pre- and postanesthesia patients. Additionally, it is a valuable tool for nursing students specializing in critical care and perianesthesia nurses preparing to sit for the certified post anesthesia nurse (CPAN) and certified ambulatory perianesthesia nurse (CAPA) certification examinations. Divided into three sections that cover the lifespan, PeriAnesthesia Nursing Care: A Bedside Guide for Safe Recovery is specifically designed to be functional for the clinician and grounding for the student nurse. The first section focuses on core concepts applicable to all perianesthesia patients and families, while the second is population specific, and the third concentrates on particular surgeries and procedures that follow body systems. --Book Jacket.

Summary: "This book presents a timely collection of reviews by experts in periconception and fertilization. The book provides a good introduction for those new to the field as well as those who have worked in this field for some time, but not have been able to keep up-to-date with recent advances on the topic. The book reviews the current knowledge in this field, then focuses its attention on short-term and long-term effects of the periconception period, both from a physiological and medical perspective. Finally the volume covers the examination of the potential mechanisms involved in controlling periconception period. From the early days of discovery about the basics of the fertilization process, scientist shave known that early events happening during conception play a major part in the creation of new offspring. However, until nearly a decade ago we thought these events were just concerned with the conception and nothing to do with lifelong health and welfare, or wellbeing of the offspring. Early indications from IVF in sheep and cattle suggested that the embryo culture conditions employed in the laboratory could result in unusually large and unhealthy offspring. These observations sounded alarm bells and stimulated research into the impacts of in vivo and in vitro conditions on the health of embryos and offspring. This book provides a summary of the state-of-the-art research being done to more fully understand the importance of the periconception environment"--Publisher's description.

Contents:
Introduction: a brief guide to the periconception environment / Alireza Fazeli, William V. Holt
Epigenetic influences during the periconception period and assisted reproduction / Akwasi A. Amoako, Tamer M. Nafee [and others]
The importance of the periconception period: immediate effects in cattle breeding and in assisted reproduction such as artificial insemination and embryo transfer / Mieke Van Eetvelde, Sonia Heras, J. L. M. R. Leroy, Ann Van Soom, Geert Opsomer
The consequences of maternal-embryonic cross talk during the periconception period on subsequent embryonic development / Dimitrios Rizos, Veronica Maillo, Maria-Jesús Sá́nchez-Calabuig [and others]
The role of maternal nutrition during the periconceptional period and its effect on offspring phenotype / Tom P. Fleming, Judith J. Eckert, Oleg Denisenko
The long-term effect of the periconception period on the embryo's epigenetic profile and phenotype: the role of maternal disease such as diabetes and how the effect is mediated (example from a rabbit model) / Bernd Fischer, Maria Schindler, S. Mareike Pendzialek, Jacqueline Gürke, Elisa Haucke [and others]
Long-term effects of the periconception period on embryo epigenetic profile and phenotype: the role of stress and how this effect is mediated / James Ord, Alireza Fazeli, Penelope J. Watt
The long-term effects of the periconceptional period on embryo epigenetic profile and phenotype; the paternal role and his contribution, and how males can affect offspring's phenotype/epigenetic profile / Emma S. Lucas, Adam J. Watkins
Exploitation of non-mammalian model organisms in epigenetic research / William V. Holt.

Summary: This volume explores novel concepts of pericyte biology. The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about the pericytes. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology in Disease, Pericyte Biology - Novel Concepts presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases. .

Contents:
Pericyte biology: development, homeostasis, and disease / Alexander Birbrair
The NG2 proteoglycan in pericyte biology / William B. Stallcup
Pericytes for therapeutic bone repair / Carolyn A. Meyers, Joan Casamitjana, Leslie Chang, Lei Zhang, Aaron W. James, Bruno Péault
Pericyte biology in zebrafish / Nabila Bahrami, Sarah J. Childs
The microvascular pericyte: approaches to isolation, characterization, and cultivation / Paula Dore-Duffy, Nilufer Esen
Pericytes in veterinary species: prospective isolation, characterization and tissue regeneration potential / Cristina L. Esteves, F. Xavier Donadeu
Pericytes in the human vocal fold mucosa / Kiminori Sato
Ca2+ signalling in pericytes / Theodor Burdyga, Lyudmyla Borysova
Pericytes derived from human pluripotent stem cells / John Jamieson, Bria Macklin, Sharon Gerecht
Pericytes in tissue engineering / Betül Çelebi-Saltik
Pericyte Secretome / Abderahim Gaceb, Gesine Paul

Summary: The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology - Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs. .

Contents:
Intro
Preface
Contents
Contributors
Pericytes in the Retina
Pancreatic Pericytes in Glucose Homeostasis and Diabetes
Pericytes in the Lung
Pericytes in Skeletal Muscle
Pericytes in the Gut
Pericytes in Bone Marrow
Cochlear Capillary Pericytes
Pericytes in the Placenta: Role in Placental Development and Homeostasis
Pericytes in the Liver
Pericytes in the Periodontal Ligament
Pericytes in the Heart
Pericytes in the Umbilical Cord
The Pluripotent Microvascular Pericytes Are the Adult Stem Cells Even in the Testis
Index

Summary: This volume explores pericytes' roles under distinct pathological conditions, ranging from tumors, ALS, Alzheimers disease, Multiple Sclerosis, stroke, diabetes, atherosclerosis, muscular dystrophies and more. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology – Novel Concepts, Pericyte Biology in Disease presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cell biology and clinicians involved with these specific diseases.

Contents:
Pericytes in cutaneous wound healing
Pericytes in glioblastomas: multifaceted role within tumor microenvironments and potential for therapeutic interventions
Pericytes in breast cancer
Pericytes in sarcomas and other mesenchymal tumors
Pericytes in metastasis
The role of pericytes in Amyotrophic Lateral Sclerosis
Pericytes in Alzheimers Disease: novel clues to cerebral amyloid angiopathy pathogenesis
Pericytes in Multiple Sclerosis
Pericytes in ischemic stroke
Pericytes in Hereditary Hemorrhagic Telangiectasia
Pericytes in primary familial brain calcification
Pericytes in type 2 diabetes
Pericytes in atherosclerosis
Pericytes in chronic lung disease
Pericytes in muscular dystrophies
Index.

Summary: Perinatal Depression among Spanish-Speaking and Latin American Women:A Global Perspective on Detection and Treatment. As more is known about postpartum depression, the more it is recognized as a global phenomenon. Yet despite the large numbers, information about this condition as experienced by Spanish speaking women and Latinas has not always been easy to come by. Perinatal Depression among Spanish-Speaking and Latin American Women focuses on four diverse Latina populations (Mexico, Chile, Spain, and U.S.) to analyze key similarities and differences within this large and wide-ranging group. This first-of-its-kind reference reviews current research on the topic, including prevalence, screening methods, interventions, and--of particular salience for this population--barriers to care. Findings on psychoeducation, assessment tools, and cognitive-behavioral and other forms of therapy provide important insights into best practices, and continuity of care. And psychosocial, cultural, and linguistic considerations in working with Latinas are described in depth for added clinical usefulness. This landmark volume: Outlines characteristics of Spanish-speaking women and Latinas screened for postpartum depression Introduces the Edinburgh Postnatal Depression Scale, English and Spanish versions, and reviews their use with Latina women Compares postpartum depression and health behaviors in Spanish and Latina immigrant mothers Offers streamlined assessment-to-intervention models Provides two in-depth case studies illustrating cultural factors influencing the treatment of Latinas with perinatal depression Presents an instructive firsthand account of postpartum depression. Between its thorough coverage of the issues and its innovative clinical ideas, Perinatal Depression among Spanish-Speaking and Latin American Women has a wealth of information of interest to researchers and practitioners in maternal and child health, obstetrics/gynecology, mental health, and women's health.

Contents:
Chapter 1. A global perspective on postpartum depression: An overview of the current research with Spanish-speaking women in the U.S. and abroad
Chapter 2. Characteristics of Hispanic Women Screened for Postpartum Depression
Chapter 3. Maternity, migration and mental health: Comparison between Spanish and Latina immigrant mothers in postpartum depression and health behaviors
Chapter 4. Assessment, Engagement and Treatment Entry for Latina Women with Perinatal Depression
Chapter 5. Screening for postpartum depression in Chilean women with the Postpartum Depression Screening Scale, Spanish version
Chapter 6. Perinatal Depression Treatments for U.S. Latinas: A Review of Research Findings
Chapter 7. Psychosocial and cultural considerations in detecting and treating depression in Latina perinatal women in the United States
Chapter 8. Perinatal depression in Mexican women: Prevalence, risk factors, and prevention of postpartum depression
Chapter 9. Treating Latinas with postpartum depression: Two case reports
Chapter 10. Maternidad Tab , the Silent Epidemic: An autobiographical story of postpartum depression in Mexico.

Summary: "Get a quick, expert overview of the fast-changing field of perinatal genetics with this concise, practical resource. Drs. Mary Norton, Jeffrey A. Kuller, and Lorraine Dugoff fully cover the clinically relevant topics that are key to providers who care for pregnant women and couples contemplating pregnancy. It's an ideal resource for Ob/Gyn physicians, maternal-fetal medicine specialists, and clinical geneticists, as well as midwives, nurse practitioners, and other obstetric providers"--Publisher's description.

Contents:
Principles of medical genetics and genomics
Non-Mendelian genetics
Principles of genetic counseling
Cytogenetics: part 1, general concepts and aneuploid conditions
Cytogenetics: part 2, structural rearrangements and reproductive impact
Molecular genetics
Carrier screening
Serum and ultrasound based screening tests for aneuploidy
Cell free DNA screening
Ultrasound markers for aneuploidy
Genetic evaluation of fetal sonographic abnormalities
Chromosomal microarray analysis
Exome and genome sequencing
Prenatal diagnostic testing
Preimplantation genetic screening and diagnosis
Fetal treatment of genetic disorders.

Summary: Perinatal psychiatry is an emerging field that investigates the role of perinatal events - for example pregnancy complications and infections - in the development of neuropsychiatric conditions, such as schizophrenia and mood disorders. Among the implicated pathological mechanisms, perinatal-induced inflammation seems to play a major role and is being considered as a potential target for therapeutic intervention. Bringing together various approaches in the field (preclinical and clinical, epidemiological, immunological and genetic methods), the book discusses the available evidence, the putative mechanisms and the challenges ahead. -- Provided by publisher.

Contents:
Perinatal psychiatry : ready for prime time? / Sudhakar Selvaraj, Haitham Salem, Cristian P. Zeni, Antonio L. Teixeira
Developmental programming during psychological stress in pregnancy : a neurobiological perspective / Natalie Aboustate, Bernhard T. Baune
Epigenetic modifications of early-life stress and adult life psychopathology / Chris Murgatroyd
Hypothalamus-pituitary-adrenal axis programming by early-life stress : a role played by inflammatory and epigenetic mechanisms / Gabriel R. Fries
Intergenerational aspects of immune and endocrine function in perinatal depression / Andrew J. Perrin, Carmine M. Pariante, Patricia A. Zunszain
Neonatal meningitis mechanisms and implications in adult life / Vijayasree V. Giridharan, Lutiana R. Simoes, Pavani Sayana, Fabricia Petronilho, Rodrigo Hasbun, Tatiana Barichello
Toxoplasma gondii infection as a risk factor for major psychiatric disorders : pre-clinical and clinical evidence / João Luís Vieira Monteiro de Barros, Aline Silva de Miranda, Antonio Lucio Teixeira
A critical appraisal on the epidemiological evidence linking perinatal inflammation and risk of psychosis / Lia Snaders, Felicia Gabler, David De Lucena
Maternal immune activation as a risk factor for schizophrenia : evidence from preclinical and clinical studies / Camila Nayane de Carvalho Lima, Tejaswini Doifode, Allan Colodel, Pavani Sayana, Vijayasree V. Giridharan, Danielle S. Macedo et al.
Sex and age influence in the effects of perinatal immune activation in animals / Danielle S. Macedo, Manuel Alves Santos Júnior, Aline Santos Monte, Germana Silva Vasconcelos, Tatiane da Silva Araújo, Silvânia Maria Mendes Vasconcelos
Maternal immune activation and neuropsychiatric disorders : the intricate puzzle of autism specturm disorder / Mellanie Fontes-Dutra, Bruna Rabelo, Júlio Santos-Terra, Iohanna
Zika virus infection and potential mechanisms implicated in neuropsychiatric complications / Fernanda Martins Marim, Vidyleison Neves Camargos, Celso Martins Queiroz-Junior, Vivian Vasconcelos Costa
The immune responses at the fetomaternal interface / Moisés Evandro Bauer, Priscila Vianna
Placenta and cord blood as source of immune markers of offspring neurodevelopment and psychopathology / Ana Cristina Simões e Siva, Janaina Matos Moreira, Rafael Coelho Magalhães
Cytokine model of cognition in relation to mental disorders during neurodevelopment / Célia Fourrier, Bernhard T. Baune.

Contents:
Normal development.- Normal and abnormal commissures development, midline anomalies
Posterior fossa malformations
Malformations of cortical development
Malformations of eye and orbit
Vascular malformations
Ventriculomegaly
Infections
Ischemic and hemorrhagic lesions
Twin to twin transfusion syndrome. .

Contents:
v.1 Reproductive health; v.2 Reproductive risk.

Summary: "The goal of the book is to provide useful clinical information to practicing perinatal nurses. A perinatal nurse assist women during their pregnancy educating about childbirth techniques, prenatal health, and what to expect throughout their pregnancy as well as how to bond and care for their baby after birth. Perinatal Nursing provides up-to-date information on best practices, standards, guidelines, etc. It is a comprehensive text for the standard of care"-- Provided by publisher.

Summary: This unique book is a first-of-its-kind resource that comprehensively covers each facet and challenge of providing optimal perinatal palliative care. Designed for a wide and multi-disciplinary audience, the subjects covered range from theoretical to the clinical and the practically relevant, and all chapters include case studies that provide real-world scenarios as additional teaching tools for the reader. Perinatal Palliative Care: A Clinical Guide is divided into four sections. Part One provides the foundation, covering an overview of the field, key theories that guide the practice of perinatal palliative care, and includes a discussion of perinatal ethics and parental experiences and needs upon receiving a life-limiting fetal diagnosis. Part Two delves further into practical clinical care, guiding readers through issues of obstetrical management, genetic counseling, neonatal pain management, non-pain symptom management, spiritual care, and perinatal bereavement care. Part Three discusses models of perinatal palliative care, closely examining evidence for different types of PPC programs: from hospital-based programs, to community-based care, and examines issues of interdisciplinary PPC care coordination, birth planning, and team support. Finally, Part Four concludes the book with a close look at special considerations in the field. In this section, racial, ethnic, and cultural perspectives and implications for PPC are discussed, along with lessons in how to provide PPC for a wide-range of clinical and other healthcare workers. The book closes with a look to the future of the field of perinatal palliative care. Thorough and practical, Perinatal Palliative Care: A Clinical Guide is an ideal resource for any healthcare practitioner working with these vulnerable patient populations, from palliative care specialists, to obstetricians, midwifes, neonatologists, hospice providers, nurses, doulas, social workers, chaplains, therapists, ethicists, and child life specialist s.

Contents:
Part 1 Foundations of Perinatal Palliative Care
1. Introduction to Perinatal Palliative Care
2. Theoretical Perspectives to Guide the Practice of Perinatal Palliative Care
3. Perinatal Ethics
4. Parental Experiences and Needs After Life-Limiting Fetal Diagnosis.-Part 2 Clinical Care for Families Facing Life-Limiting Fetal Conditions
5. Obstetrical Management in Life-Limiting Fetal Conditions
6.Genetics and Genetic Counseling in Perinatal Palliative Care.-7. The Neonatologists Role in Prenatal Counseling
8. Neonatal Pain Management
9. Non-Pain Symptom Management
10. The Role of the Palliative Care Specialist in Perinatal Care
11. Spiritual Care in the Perinatal Period
12. Perinatal Bereavement Care
Part 3 Models of Perinatal Palliative Care
13. Structure and Development of Hospital-Based Perinatal Palliative Care Programs
14. Community-Based Perinatal Palliative Care
15. Interdisciplinary Perinatal Palliative Care Coordination, Birth Planning, and Support of the Team
Part 4 Special Considerations for the Field of Perinatal Palliative Care
16. Considerations in Unique Populations in Perinatal Palliative Care: From Culture, Race, Infertility, and Beyond
17. Education in Perinatal Palliative Care for Nurses, Physicians, and Other Health Professionals
18. Advancing the Field of Perinatal Palliative Care: Needs and Strategies.

Contents:
Changes Induced by Prenatal Stress in Behavior and Brain Morphology. Can they be Prevented or Reversed?
Sleep in Prenatally Restraint Stressed Rats, a Model of Anxious Depression
Hormonal Modulation of Catecholaminergic Neurotransmission in a Prenatal Stress Model
Involvement of Nitric Oxide, Neurotrophins and HPA Axis in Neurobehavioral Alterations Induced by Prenatal Stress
Prenatal Stress and Adult Drug-seeking Behavior: Interactions with Genes and Relation to Non-drug Related Behavior
A Self-medication Hypothesis for Increased Vulnerability to Drug Abuse in Prenatally Restraint Stressed Rats
How Postnatal Insults May Program Development
Studies in Animal Models
Perinatal Positive and Negative Influences on the Early Neurobehavioral Reflex and Motor Development
Short and Long-term Consequences of Perinatal Asphyxia: Looking for Neuroprotective Strategies
Affective, Cognitive and Motivational Processes of Maternal Care
Role of Sensory, Social and Hormonal Signals from the Mother on the Development of Offspring
Retrospective Studies
Prenatal Stress and its Effects on the Fetus and the Child; Possible Underlying Biological Mechanisms
Using Natural Disasters to Study Prenatal Maternal Stress in Humans
Early Life Influences on Cognition, Behavior and Emotion in Humans: From Birth to Age 20
Perinatal Programming of Neurodevelopment. Epigenetic Mechanisms and the Prenatal Shaping of the Brain
Epigenetic Mechanisms of Perinatal Programming: Translational Approaches from Rodent to Human and Back
Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences
Impact of the Perinatal Environment on Child Development: Implications for Prevention Policies
Perinatal Programming Prevention Measures
Pregnancy Outcomes after a Maternity Intervention for Stressful EmotionS (PROMISES): A Randomised Controlled Trial.

Summary: This book focuses on recent advances in research and practical recommendations regarding the use of psychotropic drugs during pregnancy and lactation, two important social and psychological life events for women. In addition to the social context, including the addition of a new family member, many women experience the occurrence or recurrence of psychiatric disorders during the perinatal period. Psychiatric disorders during this period can have negative effects on the fetus, infant and other children in the family, and can result in functional impairment among mothers. The book offers a comprehensive overview of psychopharmacological treatments for nearly all specific psychiatric conditions (e.g. bipolar disorder, panic disorder, obsessive-compulsive disorder) and includes chapters on clinical approaches to treating these disorders. As such, it will appeal to a wide readership, including psychiatrists, obstetricians, gynecologists and pediatricians.

Summary: This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton's Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Summary: Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.

Summary: This book presents the latest evidence-based guidelines for perinatal management and is designed to help obstetricians and neonatologists minimize complications and offer patients the best possible care. Since 1960, there has been a significant increase in basic and clinical investigations on normal and pathological pregnancy in the developed world. This has provided insights into the physiopathology of pregnant women, fetuses and newborns and led to the development of new technologies, bringing about a new medical subspecialty: perinatal medicine. The book is divided into eight main sections: The first examines basic periconceptional care and discusses the ethical aspects of perinatology. The next section focuses on prenatal considerations, such as the nutritional aspects of gestation and puerperium, physical exercise during pregnancy, routine laboratory tests, prenatal care of multiple gestations and the role of the neonatologist in prenatal care. The third and fourth sections then explore fetal evaluation, and clinical intercurrences in pregnancy, respectively. The next section addresses pregnancy complications: prevention, diagnosis and management. The sixth section covers the basic aspects of congenital infections and the seventh examines labor and delivery aspects. Lastly, the final section includes chapters on neonatal assistance. Written by leading experts in obstetrics, neonatology, and perinatology, this thoroughly updated, comprehensive resource reflects the latest information in all areas, including genetics and imaging.

Summary: This book, written by very well-known opinion leaders in the field, covers all aspects of periodic and non -periodic fevers, and related disorders. The expression refers to several different auto-inflammatory diseases, showing similar symptoms-the primary symptom being a recurrent fever for an infectious cause cannot be found. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications in both pediatric and adult patients. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springers series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Periodic and Non-Periodic Fevers will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these disease.

Contents:
Preface
I From Pathogenesis to Classification
1 Historical notes on Autoinflammatory disorders
2 Pathogenesis:Genetic basis, Innate Immunity, Inflammosomes, Cytokines
3 Classification and nomenclature of Periodic and Non Periodic fevers
II Specific diseases
4 Mevalonate Kinase Deficiency (MKD)
5 Tumor necrosis factor receptors associated syndrome (TRAPS)
6 Cryopyrin-Associated Periodic Syndromes (CAPS)
7 Pyogenic Arthritis, Pyoderma gangrenosum and Acne Syndrome (PAPA)
8 Adenosine deaminase syndrome 2 (ADA2)
9 Interferonopathies
10 Inflammatory bone disease
11 Amyloidosis
12 Dermatologic autoinflammatory diseases
13 Autoinflammatory diseases with immunodeficiency
14 Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome (PFAPA)
15 Proteasome. related disorders
16 Chronic Non-bacterial osteomyelitis
17 Systemic JIA and adult onset Still disease
18 Behcet disease
19 Recurrent idiopathic pericarditis
20 Schnitzler syndrome
Subject Index.

Summary: This book is an evidence-based guide to periodontal root coverage that provides up-to-date information on the etiology of gingival recession defects, prognostic factors relating to the defect, patient, or operator, and surgical techniques. Attention is drawn to critical elements in the execution of surgical procedures that can impact on outcomes. In order to ensure that the guidance reflects the highest level of evidence, the authors have undertaken an exhaustive literature search of the four main electronic databases (MEDLINE/PubMed, Cochrane Library, ScienceDirect, and EBSCOhost) for studies on root coverage, including randomized clinical trials, systematic reviews, meta-analyses, and network meta-analyses. The aim is to supply readers with a truly reliable source of knowledge that will help them to navigate this complex field, in which numerous surgical procedures have been described, with great variability in clinical and statistical outcomes. The book will be of value to all who wish to improve their understanding of gingival recession defects and the techniques to achieve root coverage that offer the best long-term results.

Contents:
Intro; Foreword; Contents; About the Authors; Part I;
1: Gingival Recessions: Definition and Classification; 1.1 Definition; 1.2 Classifications; 1.2.1 Classification of Sullivan and Atkins [9]; 1.2.2 Classification of Miller [10]; 1.2.3 Classification of Cairo [11]; References;
2: Etiology of Gingival Recessions; 2.1 Anatomical Factors; 2.1.1 Thin Gingival Biotype; 2.1.2 Abnormal Tooth Position; 2.1.3 High Frenum Attachment; 2.2 Pathological Factors; 2.2.1 Periodontal Disease; 2.2.2 Bacterial Plaque; 2.2.3 Dental Calculus; 2.3 Traumatic Factors; 2.3.1 Toothbrushing; 2.3.2 Flossing Trauma; 2.4 Iatrogenic Factors; 2.4.1 Orthodontic Movement; 2.4.2 Prosthetic and Restorative Treatment; References;
3: Summary; Part II;
4: Prognostic Factors: Defect Related Factors; 4.1 Recession Classification; 4.2 Recession Size; 4.3 Adjacent Papilla Dimension; 4.4 Keratinized Tissue; 4.5 Noncarious Cervical Lesions (NCCLs); 4.6 Tooth Malposition and Tooth Location; References;
5: Prognostic Factors: Patient Related Factors; 5.1 Plaque Control; 5.2 Toothbrushing; 5.3 Tobacco Smoking; References;
6: Prognostic Factors: Operator-Related Factors; References;
7: SummaryPart III;
8: Surgical Procedures; 8.1 Free Gingival Graft (FGG); 8.2 Coronally Advanced Flap (CAF); 8.2.1 Coronally Advanced Flap (CAF) for the Management of Isolated Gingival Recession Defects; 8.2.2 Coronally Advanced Flap (CAF) for the Management of Multiple Gingival Recession Defects; 8.3 Laterally Positioned Flap (LPF); 8.4 Double Papilla Flap (DPF); 8.5 Tunnel Technique; 8.6 Summary; References;
9: Critical Factors in Execution; 9.1 Root Conditioning; 9.2 Flap Tension/Stability; 9.3 Microsurgical Approach; 9.4 Summary; References.

Summary: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book "Periodontitis: Advances in Experimental Research" includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book "Periodontitis: Advances in Experimental Research" is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).

Contents:
Preface
Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca)
Part I: Periodontal microbiota
Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric)
Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza)
Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira)
Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca)
Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik)
Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero)
Part II: Periodontitis pathophysiology
Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva)
Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers)
Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández)
Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer)
Part III: Periodontitis-associated conditions
Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners)
Chapter 13. Periodontitis as a risk factor for Alzheimer's disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao)
Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup)
Part IV: Therapeutic management of periodontitis
Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás)
Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux)
Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners)
Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani)
Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer)
Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun)
Index.

Summary: This book guides through all essentials in the field of periodontology including the pathology, diagnosis, and treatment of the most common periodontal conditions. Now in its 4th edition, this fully updated version marks the 25th anniversary of the first edition. It discusses the developments in classification while maintaining a no-nonsense logical approach to what many people find a complex subject. The book will help clinicians acquire and maintain the knowledge and skill to treat the many patients encountered in day-to-day practice. It covers the scientific background of periodontal-systemic disease interactions, the clinical application of periodontal surgery and the management of multi-rooted teeth. With newly incorporated supplementary information, the book will be a helpful source for general dentist, dental students, dental hygienists and even for postgraduate students.

Contents:
1. Periodontal examination and screening
2. Pathology of periodontal disease
3. Periodontal disease and systemic health
4. Diagnosis, prognosis and treatment planning
5. Effective communication with patients to improve motivation
6. Non-surgical treatment and supportive periodontal care
7. Periodontal surgery
8. Treatment of multi-rooted teeth
9. Reconstructive periodontal treatment
10. Multidisciplinary integrated treatment
11. Diagnosis and management of acute conditions
12. Patient presentations.

Summary: More than 80% of patients with cancer will need the services of anesthesiology and perioperative medicine, intensive care medicine, and pain management specialists during their cancer journey for diagnostic, therapeutic, and symptom management needs, as well as for the management of recurrent disease, secondary cancers, and ongoing non-oncologic surgical needs during survivorship. Perioperative Care of the Cancer Patient is today's most up-to-date, authoritative, comprehensive reference on the acute care of surgical patients with cancer, from a team of international experts in this emerging and dynamic specialty-- publisher's description.

Summary: "Older patients carry some of the highest risks of suffering an adverse event or death following anesthesia and surgery. They are inherently vulnerable, presenting with numerous comorbidities and reduced physiological reserve, requiring 'gero-centric' perioperative care for everything from routine eye surgery to major cardiac surgeries. Dementia, frailty, and the need for palliative care and pain management for the orthopedic patient are important areas requiring special consideration in this group. This book provides a general overview of these topics for those healthcare providers who may not have extensive knowledge of this patient population, while at the same time offering practical tips for the more experienced clinician. Chapters cover the spectrum of perioperative care including preoperative management of comorbid conditions, intraoperative anesthetic management, postoperative pain control, and a primer on advanced directive discussions. This book is appropriate not only for anesthesiologists but for any perioperative physician caring for the older patient"--Publisher's description.

Contents:
Part I: Preoperative Conditions
General Principles and Practices of Perioperative Medicine
The Prevalence of Disabling Musculoskeletal Conditions and the Demand for Orthopedic Surgery in the 21st Century
The Connective Diseases: The Rheumatologist's Perspective
The Pathophysiologic Events of Total Joint Replacement Surgery
Part II: Anesthesiological Management
Anesthesiology in the Orthopedic Patient
Pediatric Anesthesia for Orthopedic Surgery
Anesthetic Techniques and Their Clinical Application for Specific Orthopedic Procedures
The Role of the Post-Anesthesia Care Unit in the Perioperative Care of the Orthopedic Patient
Postoperative Pain Management in the Orthopedic Setting
Part III: Medical Management in Specific Clinical Settings
Perioperative Care of the Orthopedic Patient with Connective Tissue Disease
Perioperative Care of the Orthopedic Patient with Cardiac Disease
Perioperative Care of the Orthopedic Patient with Chronic Pulmonary Disease
Perioperative Care of the Orthopedic Patient with Renal Disease
Perioperative Care of the Orthopedic Patient with Diabetes Mellitus
Perioperative Care of the Orthopedic Patient with Gastrointestinal and Liver Issues
Perioperative Care of the Orthopedic Patient with Neurological Disease
Perioperative Care of the Orthopedic Patient with Psychiatric Disease
Part IV: Specific Perioperative Problems in Orthopedic Surgery
Perioperative Care of the Elderly Orthopedic Patient
Venous Thromboembolism and Orthopedic Surgery
Coagulation Disorders and Orthopedic Surgery
Perioperative Nutrition in the Orthopedic Surgical Patient
Infection and Perioperative Orthopedic Care
Risk and Benefits of Bilateral Total Knee Replacement Surgery
Compartment Syndrome and Orthopedic Surgery: Diagnosis and Management
Bone Health and Orthopedic Surgery
Perioperative Care of theComplex Spine and Scoliosis SurgeryPatient
Management of Blood Products in Orthopedic Surgery
Part V: Role of Allied Services
Professional Nursing Practice in the Orthopedic Care Setting
The Approach to Physical Therapy Following Orthopedic Reconstructive Surgery
Quality Improvement in the Perioperative Orthopedic Setting
Introduction of Clinical Pathways in Orthopedic Surgical Care: The Experience of the Hospital for Special Surgery
Ethical Considerations in Perioperative Orthopedic Medicine.

Summary: References -- 2: Perioperative Risk Models -- Introduction -- General Risk Assessment Models -- Cardiac Risk Assessment Tools -- Pulmonary Risk Assessment Tools -- Hepatic Risk Assessment Tools -- Venous Thromboembolism Risk Assessment Tools -- Renal/Genitourinary Risk Assessment Tools -- Additional Models -- Discussion and Summary -- Case Study -- How Does One Approach the Perioperative Risk Assessment of Such a Patient? -- References -- 3: The Prevalence of Disabling Musculoskeletal Conditions and the Demand for Orthopedic Surgery in the Twenty-First Century -- Introduction This is a comprehensive, multidisciplinary manual providing preoperative considerations, postoperative complications, and guidelines for the anesthetic and medical management of patients undergoing orthopedic surgery. The editors are leaders in their field.

Contents:
Intro
Foreword to the Second Edition
Preface to the Second Edition
Preface to the First Edition
Contents
Contributors
Part I: Preoperative Considerations
1: General Principles and Practices of Perioperative Medicine
Introduction
Preoperative Consultation
Goals of the Preoperative Medical Consultation
Identification of Conditions that Affect Postoperative Outcome
Optimization of Conditions that May Affect Postoperative Outcome
The Assessment of Perioperative Risk
Patient Education and Preventive Practices
Efficacy of Preoperative Consultation Incidence of Degenerative Disorders of the Spine
Incidence of Spine Procedures
Incidence of Complications After Spine Surgery
Definition and Classification of Complications
Study Methodology
Surgeon-Related Factors
Procedure-Related Factors
Patient-Related Factors
Prevalence of Osteoarthritis and Related Reconstructive Surgeries of the Hip and Knee
The Incidence of Complications After Total Knee and Total Hip Arthroplasty
General Trends
Specific Complications: Medical
Infection
Dislocation
Venous Thromboembolism
Periprosthetic Fractures
Summary Effects in Other Organ Systems
The Role of Embolic Load
The Role of Cement
The Role of Fat Embolization: The Fat Embolism Syndrome
The Pathophysiology of Spine Fusion Surgery
Timing of Complications
Interventions
Summary
Case Study
References
Part II: Anesthesiologic Management
6: Anesthesia in the Orthopedic Patient
Introduction
The Orthopedic Population
Advanced Age
Rheumatoid Arthritis
Osteoarthritis
Positioning
Regional Anesthesia
Mortality
Postoperative Analgesia and Rehabilitation
Respiratory Complications

Summary: This book presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patientsℓ́ℓ outcomes. Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Perioperative Fluid Management will be of interest to anesthesiologists and also intensivists.

Contents:
PART I. FUNDAMENTALS OF FLUID MANAGEMENT
1. A History of Fluid Management / Elizabeth A. M. Frost
2. The Revised Starling Principle and Its Relevance to Perioperative Fluid Management / C. Charles Michel , Kenton P. Arkill , and FitzRoy E. Curry
3. The Functions of Endothelial Glycocalyx and Their Effects on Patient Outcomes During the Perioperative Period. A Review of Current Methods to Evaluate Structure-Function Relations in the Glycocalyx in Both Basic Research and Clinical Settings / FitzRoy E. Curry , Kenton P. Arkill , and C. Charles Michel
4. Techniques for Goal-Directed Fluid Management / Paul E. Marik
5. The Perioperative Use of Echocardiography for Fluid Management / Maged Argalious
6. Microcirculatory Blood Flow as a New Tool for Perioperative Fluid Management / Daniel De Backer
7. Mean Systemic Filling Pressure Is an Old Concept but a New Tool for Fluid Management / Hollmann D. Aya and Maurizio Cecconi
8. Restricted or Liberal Fluid Therapy / Thomas E. Woodcock
9. The Perioperative Use of Albumin / Ehab Farag and Zeyd Y. Ebrahim
10. The Dilemma for Using Hydroxyethyl Starch Solutions for Perioperative Fluid Management / Christiane S. Hartog and Konrad Reinhart
11. Balanced Versus Unbalanced Salt Solutions in the Perioperative Period / Sheldon Magder
12.Positive Fluid Balance and Patients' Outcomes / John Danziger
13. Fluid Management and Its Role in Enhanced Recovery / Andrew F. Cumpstey , Michael P. W. Grocott , and Michael (Monty) G. Mythen
PART II. CASE SCENARIOS MANAGEMENT DURING COLORECTAL, ORTHOPEDIC, AND SPINE CASES
14. Case Scenario for Perioperative Fluid Management in Major Orthopedic Surgery / Wael Ali Sakr Esa
15. Case Scenario for Perioperative Fluid Management for Major Colorectal Surgery / Kamal Maheshwari
16. Case Scenario for Fluid Therapy in Septic Shock / William Phillips
17. Case Scenario for Fluid Management in Liver Resection / Maged Argalious and Harendra Arora
18. Case Scenario for Fluid Management During Major Spine Surgery / Verna L. Baughman
19. Case Scenario for Fluid Management After Subarachnoid Hemorrhage in the Neuro- intensive Care Unit / Jamil R. Dibu and Edward M. Manno.

Summary: This revised and expanded second edition presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patients' outcomes. Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Lastly, case scenarios for every possible clinical situation describe in full the most up-to-date fluid management for the corresponding clinical problem. Perioperative Fluid Management, Second Edition is of interest to anesthesiologists and also intensivists.

Contents:
Part I Fundamentals of Fluid Management
A History of Fluid Management
The Revised Starling Principle and Its Relevance to Perioperative Fluid Management
The Functions of Endothelial Glycocalyx and Their Effects on Patient Outcomes During the Perioperative Period. A Review of Current Methods to Evaluate Structure-Function Relations in the Glycocalyx in Both Basic Research and Clinical Settings
Techniques for Goal-Directed Fluid Management
The Perioperative Use of Echocardiography for Fluid Management
Microcirculatory Blood Flow as a New Tool for Perioperative Fluid Management
Mean Systemic Filling Pressure Is an Old Concept but a New Tool for Fluid Management
Restricted or Liberal Fluid Therapy
The Perioperative Use of Albumin
The Use of Albumin in Intensive Care Unit
The Dilemma for Using Hydroxyethyl Starch Solutions for Perioperative Fluid Management
Balanced Versus Unbalanced Salt Solutions in the Perioperative Period
Positive Fluid Balance and Patients' Outcomes
Fluid Management and Its Role in Enhanced Recovery
Venous Circulation: a New Concept in Fluid Management
Pathophysiology of Fluid Management in Neonate and Pediatric Patient
Zero Fluid Balance versus Liberal Fluid Management. pro and Con
Pathophysiology of perioperative Fluid Management from Surgeon Point of View
Part II FluidManagement Case Scenarios
Case Scenario for Perioperative Fluid Management in Major Orthopedic Surgery
Case Scenario for Perioperative Fluid Management for Major Colorectal Surgery
Case Scenario for Fluid Therapy in Septic Shock
Case Scenario for Fluid Management in Liver Resection
Case Scenario for Fluid Management During Major Spine Surgery
Case Scenario for Fluid Management After Subarachnoid Hemorrhage in the Neuro- intensive Care Unit
Case Scenario for Fluid Management during Open Heart Surgery
Case Scenario for Fluid Management during Thoracic Surgery
Case Scenario for Fluid Management during Major Vascular Surgery
Case Scenario for Fluid Management for Patients in Cardiothoracic Intensive Care.

Summary: All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthetist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthetic subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthetists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.

Contents:
Part I: Pre-operative haemostasis: Cell based coagulation model
Laboratory testing of hemostasis
Viscoelastic tests of hemostasis
Point of care platelet function tests
Hemostasis assessment and evaluation
Hereditary coagulopathies
Acquired coagulopathies
Drug induced
Antiplatelet drugs
Intravenous fluids and coagulation
Split blood products
Isolated coagulation products
Pro-coagulant drugs
Patient blood management. Part II: Per-operative haemostasis: In cardiac surgery
In Hepatic Surgery
In Pediatric Surgery
In Obstetrics Surgery
In Trauma
In Neurosurgery
In Orthopedic Surgery
In Neuraxial and Peripheral Nerve blocks. Part III: Post-Operative: Intensive Care
Anti-Coagulation. Part IV: Economic aspects and organization.

Summary: The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay, and cost. Peri-operative Kidney Injury presents the epidemiology, risk factors, diagnosis, treatment, and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac, and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.

Contents:
Part I Peri-operative AKI: Overview and Approach
1 Incidence, Trends and Diagnosis of Peri-operative AKI
2 Serious peri-operative complications: Hospital Medicine Perspectives
3 Role of Novel Kidney Injury Biomarkers in Perioperative AKI
4 Clinical Pearls: Renal Replacement Therapy for AKI in the Post-operative Period.- 5 Clinical Pearls: Non-dialytic Management of Kidney Complications in the Post-operative Period
6 Intra-Operative Considerations to Prevent Post-Operative AKI
Part II Cardiac and Vascular Surgery
7 AKI after Cardiac Surgery in Adults.- 8 AKI after Cardiovascular Surgery in Children
9 AKI in the Era of Ventricular Assist Devices.- 10 Kidney Injury after Vascular Surgery.- Part III Abdominal and Urologic Surgery.- 11 AKI after Major Abdominal Surgery.- 12 Kidney Injury in Abdominal Compartment Syndrome.- 13 Kidney Function and Injury after Nephrectomy for Kidney Cancer
Part IV Transplant Surgery
14 The Kidney in Non-Renal Solid Organ Transplantation
15 Acute Allograft Injury After Kidney Transplantation
Part V Special Topics in Peri-operative AKI.- 16 Trauma and Acute Kidney Injury
17 Fluid-Electrolyte Imbalances and Extra-Corporeal Therapy in the Neurosurgical Setting
18 Nutrition in Peri-operative Patients with Kidney Failure.

Contents:
Perioperative medicine: defining the anaesthesiologist's role in shaping perioperative outcomes
Prehabilitation
Impact of co-morbidities, physiological status and age on survival
Transthoracic echocardiography in the preoperative clinic
Defining postoperative quality of recovery
Enhanced recovery for colorectal surgery
Perioperative beta-blockade: the pros and cons. The story of beta-blockade and cardiac protection
Perioperative management of the diabetic patient
Perioperative management of non-diabetic patients with hyperglycaemia (stress-induced hyperglycaemia)
Postoperative Pulmonary Complications
Haemostatic resuscitation for perioperative bleeding
Fluid therapy in trauma
Role of multimodal monitoring in the perioperative period: improving outcomes in high-risk surgical patients
Can perioperative interventions during cancer surgery affect recurrence or metastasis?
Transverse abdominis plane block: evolution and current understanding
Future ultrasound technologies for the perioperative physician
Lung ultrasound in anaesthesia and critical care medicine
The acute pain team
The transition of acute post-operative pain to acute persistent pain to chronic pain: assessing and managing the risks.

Summary: Based on the most current evidence and best practices, Perioperative Medicine: Managing for Outcome, 2nd Edition, is an easy-to-follow, authoritative guide to achieving optimal outcomes in perioperative care. Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing decision trees that define strategies to enhance the medical outcome of care. Focuses on what anesthesiologists, surgeons, and intensivists need to know in order to improve outcomes through evidence- and outcome-based approaches. Provides practical guidance on potential risks to all major organ systems, the etiology of particular organ dysfunctions, preoperative and intraoperative risk factors, and perioperative protection strategies to minimize potential complications. Features a consistent chapter format - with even more color-coded algorithms, summary tables, and boxes - that enables you to quickly explore and determine the best management approaches. Includes six all-new chapters: Perioperative Fluid Management; Delirium and POCD; Role of Palliative Care/ICU; Value-Based Care: The UK Model; CFO Perspective on Value; Hospital to Home (Perioperative Transitions of Care) Discusses timely topics such as quality improvement, pay-for-performance, preexisting disease and comorbid conditions in anesthesiology, and the team-based model of care. Features two new editors, surgeon Clifford Ko, MD, and Perioperative Summit leader, Michael (Monty) Mythen, MD. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Summary: This comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.

Contents:
Introduction
The Preoperative Evaluation
Perioperative Medication Management
Anesthesia Fundamentals
Cardiovascular Risk Stratification
Ischemic Heart Disease
Congestive Heart Failure
Atrial Fibrillation
Hypertension
Valvular Heart Disease
Implantable Cardiac Devices
Diabetes
Stress Dose Steroids
Thyroid Disease
Hormone Therapy and Transgender Patients
Liver Disease
Inflammatory Bowel Disease
Chronic Anticoagulation
Disorders of Hemostasis
Thrombophilias
Thrombocytopenia
Anemia
Sickle Cell Disease
Venous Thromboembolic Disease
Cerebrovascular Disease
Epilepsy and Seizure Disorders
Parkinsons Disease
Spinal Cord Injury
Chronic Pain
Pulmonary Risk Assessment and Management
Asthma and COPD
Obstructive Sleep Apnea / Obesity Hypoventilation Syndrome
Pulmonary Hypertension
Special Topics in Lung Disease: Restrictive, Myesthenia Gravis
Chronic Kidney Disease
Acute Kidney Injury
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Gout and Pseudogout
Decision-Making Capacity
Elderly Patients and Frailty
Nutrition
Patients with Solid Organ Transplant
Substance Use and Dependence
Postoperative Evaluation and Care
Postoperative Fever
Postoperative Delirium
Postoperative Ileus
Postoperative Hypoxemia
Postoperative Tachycardia
Postoperative Emergencies
Postoperative Electrolyte Abnormalities
Acute Pain Management Pearls
Surgical Procedures Overview.

Contents:
Introduction
Perioperative medicine and anesthesia
PART I Perioperative care before surgery
Preoperative evaluation
Preoperative preparation
Prehospital care and transport
PART II Perioperative care during surgery
Perioperative care in day hospital surgery
Perioperative care in remote locations
Perioperative care in orthopedic surgery
Perioperative care of the neurosurgical patient
Perioperative care in thoracic surgery
Perioperative care in abdominal and urological surgery
PART III Perioperative care in special situations and conditions
Perioperative care of children with difficult airway
Perioperative care of children with neuromuscular disease
Perioperative care of children with metabolic disease
Perioperative care in children with congenital heart disease
Perioperative care of children with OSA
Perioperative care of children with trauma
Perioperative care of children with cancer
Perioperative care of children with cerebral palsy and behavioural problems
PART IV Important techniques for perioperative care
Vascular and nonvascular access in the perioperative period
US-guided nerve targets
Noninvasive hemodynamic and respiratory monitoring during the perioperative period
PART V. Early and long term consequences of anesthesia and surgery
Negative behavior after surgery
Acute pain prevention and control
How to protect the infant brain during surgery
Can anesthesia induce apoptosis in children?- Long-term consequences of anesthesia and surgery on the infant brain
Prevention of chronic postsurgical pain.

Summary: "The occurrence of personality, sensory and cognitive disturbances after anesthesia and surgery has been recognized for many decades, although the magnitude, duration and causes have remained a matter of debate. Certainly the transient occurrence of delirium after surgery is well known, and the various forms are reviewed here by Drs. Proekt, Gabbard, Sieber and Oh. The more durable forms of cognitive impairment after surgery have been more enigmatic. In the past two decades, the application of strict neurocognitive testing by research groups have definitively documented impairments lasting from weeks to months, and thus a term was coined; post-operative cognitive dysfunction" or POCD, a "syndrome" reviewed in depth here by Drs. Nelli, Culley and Crosby. Complicating the analysis of POCD has been the fact that a large number of patients may actually have cognitive improvement as a result of enhanced mobility after orthopedic surgery or reduced pain perhaps following cancer resection. Thus, post-operative cognitive improvement (POCI) is reviewed here by Drs. Arias, Sibille and Price Completing the first section of this book is the more contentious, but critically important topic of whether anesthesia and surgery result in a persistent cognitive disorder, such as mild cognitive impairment or dementia, an area discussed in detail by Drs. Schenning and Hogan"--Provided by publisher.

Summary: This comprehensive text is an easy-to-access reference that provides a foundation for understanding contemporary evidence-based practices relating to pain management in the perioperative setting. Chapters review the exponential increase in prescription drug abuse associated with the "opioid epidemic"; surgeons' important role in managing perioperative and chronic pain in a variety of practice settings; the role of quality improvement in patient safety initiatives; inadequate opioid prescribing education (OPE) in surgical training programs; and literature demonstrating the existence of evidence-based alternatives to opioids. Written and edited by experts in the field of anesthesiology and pain medicine, Perioperative Pain Control: Tools for Surgeons is a practical resource for surgical trainees and surgeons of all specialties including general surgery, thoracic surgery, otolaryngology, plastic surgery, urology, gynecology, vascular surgery, neurosurgery, and orthopedic surgery.

Contents:
Perioperative Pain Control: Practical Tools for Surgeons
The Surgeon's Role in the Opioid Epidemic
Pain Prescription Legislation: What You Need to Know as the Surgeon
Opioid Prescribing Education in Surgical Training (Follow COP)
Pre-operative Optimization
Non-Opioid Adjuncts and Alternatives
Post-Operative Analgesia for the Chronic Pain Patient
Non-Enteral Pain Management
Perioperative Annalgesia in General Abdominal, Vascular, and Thoracic Surgery
Perioperative Analgesia for Thyroid and Parathyroid Surgery
Evidence-Based Perioperative Analgesia for Otolaryngology-Head and Neck Surgery
Perioperative Analgesia in Cranial and Skull Base Surgery
Perioperative Analgesia for Orthopedic and Spine Surgery
Evidence-Based Perioperative Analgesia for Urologic Surgery
Obstetrics and Gynecology
Perioperative Analgesia and Pain Management in Pediatric Patients
Approaches to Perioperative Pain Management in the Plastic Surgical Patient. .

Summary: "Quality improvement (QI) principles are increasingly important in every area of today's healthcare, encompassing efforts to make healthcare delivery safer, more effective, patient-centered, timely, equitable, and efficient. Perioperative Quality Improvement provides up-to-date, easy-to-read guidance for perioperative clinicians on this critical topic. Each chapter covers a pertinent area of QI in the perioperative setting, focusing on both concepts and implementation. Written and edited by key international opinion leaders in the field, this text is a relevant, concise resource for anesthesiologists, surgeons, nurse anesthetists, and hospitalists--anyone involved in perioperative medicine regardless of specialty area"-- publisher's description.

Contents:
Principles and the normal heart
Getting started with echocardiography: the twenty standard views
Principles and physics: principles of ultrasound
Principles and physics: principles of Doppler ultrasound
Principles and physics: equations to remember (the Bernoulli equation, velocity-time integrals, and the continuity equation)
Principles and physics: transducer characteristics
Principles and physics: imaging artifacts and pitfalls
Normal anatomy and flow during the complete examination: components of the complete examination
Normal anatomy and flow during the complete examination: epiaortic imaging
Normal anatomy and flow during the complete examination: three-dimensional views: replicating the surgeon's view
Normal anatomy and flow during the complete examination: extracardiac anatomy
Quantitative and semiquantitative echocardiography: dimensions and flows
Quantitative and semiquantitative echocardiography: ventricular and valvular physiology
Understanding how transesophageal echocardiography demonstrates cardiovascular pathology
Myocardial ischemia and aortic atherosclerosis
Aortic valve anatomy and embryology
Mitral valvular disease
Tricuspid valvular disease
Pulmonic valvular disease
Cardiomyopathies
Aneurysms and dissections
Endocarditis
Imaging of cardiac tumors and solid and gaseous materials
Intracardiac devices, catheters, and cannulas
Echocardiographic evaluation of pericardial disease
Adult congenital heart disease
Pulmonary hypertension
Recent advances
Maintaining quality of perioperative echocardiography
Indications for transesophageal echocardiography
Complications of transesophageal echocardiography
Equipment, infection control, and safety
Oversight and administration
Training and certification for transesophageal echocardiography
Medical insurance claims, compliance, and reimbursement for anesthesiology
Regulatory, legal, and liability issues pertaining to transesophageal echocardiography.

Summary: This title represents a comprehensive manual of periorbital rejuvenation and includes an in-depth review of the anatomy of the orbit and periorbital region. Physiological changes associated with the aging of the periorbital region and potential rejuvenation options are also covered, while readers are given a series of step-by-step illustrative guides to procedural techniques. The book provides a valuable selection of clinical pearls on how to avoid potential pitfalls using a number of cases in which a range of potential invasive and non-invasive treatment options, including neuromodulators and cosmeceuticals, are used. Periorbital Rejuvenation: A Practical Manual provides a comprehensive and concise overview of periorbital anatomy and the potential effects of aging. Cutting-edge laser treatment options including laser assisted and neuromodulator techniques are ideal for the trainee to develop their knowledge and as a reference guide for the experienced practitioner.

Contents:
1. Anatomy of the Orbit and periorbital region
2. Aging of the orbit and rejuvenation options
3. Eye Medications and its effect on orbital fat and cosmesis
4. Soft tissue fillers for the periorbital region
5. Neuromodulators in Periorbital Rejuvenation
6. CHEMICAL PEELINGS IN THE PERIORBITAL REGION
7. Periorbital rejuvenation by lasers and energy-based devices
8. Oculoplastic surgery for periorbital rejuvenation
9. Cosmeceuticals for the periorbital region
10. Editor's Tips.

Contents:
Diagnostic Biopsy Procedures
Cutaneous Surgery
Hand Surgery
Foot Surgery
Hernia Surgery
Head and Neck Surgery.

Summary: This book examines new technologies (device and pharmacologic) that have evolved over the past few years in treating peripheral arterial disease. Chapters offer optimal strategies to treat PAD, supported by peer-reviewed data. The pillars of this strategy will focus on (a) changing vessel compliance to allow better lumen expansion, (b) less recoil and dissections, and (c) less bailout stenting. Chapters also review embolic protection devices and apply the adjunctive use of anti-proliferative therapy to maintain good long term outcomes. In addition, the book reviews drug coated balloons and drug eluting stent technologies and other means of drug delivery into the vessel wall. The goal of this book is to discuss all these emerging technologies under the strategy of treating patients with the focus on both acute and long term outcomes. Featuring world renown experts, this book offers a critical and comprehensive overview of the current data and future directions that would pave the way for optimal PAD management. Peripheral Arterial Interventions is an essential resource for physicians, residents, fellows, and medical students in cardiology, radiology, vascular surgery, primary care, and health promotion and disease prevention as well as internal and vascular medicine specialists.

Contents:
Chapter 1. Atherosclerosis and inflammation in Peripheral Arterial Disease
Chapter 2. Epidemiology and Public Health Implications of Peripheral Arterial Disease
Chapter 3. Risk factors and Outcomes of Patients with Peripheral Arterial Disease
Chapter 4. Pharmacologic Interventions in Patients with Peripheral Arterial Disease
Chapter 5. The Role of Exercise in Managing the PAD patient
Chapter 6. Vessel Compliance, Barotrauma and Dissections with Endovascular Therapy of the PAD patient
Chapter 7. Femoropopliteal Dissections and Their Impact on Procedural and Long Term Outcomes
Chapter 8. The Role of Atherectomy in Vessel Prepping Prior to Definitive Endovascular Treatment of the PAD patient
Chapter 9. Lithoplasty of severe calcified disease
Chapter 10. Specialty balloons and Vessel Prepping
Chapter 11. The FLEX atherotome role in reducing dissections and stenting
Chapter 12. Distal embolization in treating PAD
Chapter 13. Drug coated balloons in infrainguinal arterial interventions
Chapter 14. Iliac artery Disease Management
Chapter 15. Drug Eluting Stents in PAD management
Chapter 16. Infrapopliteal Artery Interventions in Critical Limb Ischemia Patients
Chapter 17. Reducing the Metal Burden in the infrainguinal arteries: Tack Endovascular System and Spot Stenting
Chapter 18. Approach to Chronic Total Occlusions
Chapter 19. Thrombotic Infrainguinal Arterial Disease: Mechanical and Pharmacological Approaches to Therapy
Chapter 20. Endovascular Management of Aortic Aneurysms
Chapter 21. Putting it All Together: An algorithm based approach to managing the PAD patient.

Contents:
Epidemiology of PAD
Office evaluation of peripheral artery disease : history and physical examination strategies
Vascular laboratory evaluation of peripheral artery disease
Magnetic resonance, computed tomographic, and angiographic imaging of peripheral arterial disease
Non-atherosclerotic peripheral artery disease
Medical therapy of peripheral artery disease
Endovascular treatment of peripheral artery disease
When to refer patients with claudication.

Summary: This book discusses interventional treatment options on intractable (drug resistant) headache patients and extended headache attacks and extensively reviews the reasons behind treatment failure in intractable headaches, offering potential solutions based on clinical black holes of headache outpatient practice. The most appropriate interventions for certain types of headache such as chronic migraine and medication-overuse headaches, are discussed among others. The book provides practical advice on properly administering the interventional treatments either as a bridge treatments or prophylaxis options. The expected complications of the treatments, and strategies to minimize them are also discussed. Approaches in special patient populations such as pediatric or pregnancy cases and other non-standard cases are also extensively discussed.

Contents:
Intro; Foreword; Preface; Contents; Contributors; List of Videos;
Chapter 1: Introduction to Interventional Procedures; Timing and Patient Selection; 1.1 About Headache; 1.2 Management; 1.3 Interventional Techniques; References;
Chapter 2: Headache Anatomy and Mechanisms of Peripheral Nerve Interventions; 2.1 Transmission of Nociception from Peripheral Structures; 2.2 Convergence of Peripheral Inputs on Second-Order Neurons; 2.3 Projections to the Thalamus; 2.4 Projections to the Brainstem and Hypothalamus; 2.5 Sphenopalatine Ganglion; 2.6 The Vagus Nerve and Parasympathetic Efferents 2.7 Antinociceptive ProjectionsReferences;
Chapter 3: Pharmacology of Interventional Headache Management; 3.1 Local Anesthetics; 3.1.1 Mechanism of Action; 3.1.2 Recommended Doses; 3.1.3 Side Effects; 3.2 Corticosteroids; 3.2.1 Mechanism of Action; 3.2.2 Recommended Doses; 3.2.3 Side Effects; 3.3 Botulinum Toxin; 3.3.1 Mechanism of Action; 3.3.2 BoNT Preparations; 3.3.3 Efficacy; 3.3.4 Immunogenicity; 3.3.5 Side Effects; 3.3.6 Contraindications; 3.3.7 Recommended Doses; References;
Chapter 4: Greater Occipital Nerve and Lesser Occipital Nerve Blocks 4.1 GON and LON Blocks for the Treatment of Various Headache Types4.1.1 Cluster Headache; 4.1.2 Migraine; 4.1.3 Occipital Neuralgia; 4.1.4 Postdural Puncture Headache; 4.2 Treatment Intervals and the Drugs; 4.3 Outcome; 4.4 Side Effects; 4.5 Contraindications; 4.6 Personal Comments; References;
Chapter 5: The Role of Other Peripheral Nerve Blocks; 5.1 Nerve Blocks; 5.1.1 Auriculotemporal Nerve Block; 5.1.2 Supratrochlear Nerve Block; 5.1.3 Supraorbital Nerve Block; 5.1.4 Infraorbital Nerve Block; 5.1.5 Mental Nerve Block; 5.1.6 Sphenopalatine Ganglion Block; 5.1.7 Cervical Root Block
Chapter 7: The Role of Interventional Procedures in Childhood and Adolescent Headaches-Peripheral Neuromodulation7.1 Greater Occipital Nerve Block; 7.1.1 Selection of Patients; 7.1.2 Contraindications for GON Block; 7.1.3 GON Block Procedure; 7.1.4 Response to Treatment; 7.2 Greater Occipital Nerve Stimulation; 7.3 Trigeminal Nerve Stimulation: Supraorbital Branch; 7.4 Transcranial Magnetic Stimulation; References;
Chapter 8: Interventional Headache Management in The Elderly; 8.1 Botulinum Toxin (BonT) Treatment; 8.2 Peripheral Nerve Blocks; References

Summary: This book provides extensive knowledge of peripheral lymphedema, including the etiology and pathophysiology of the disease, as well as the anatomy and physiology of the lymphatic system and guide for the treatment of lymphedema to clinicians. The ultimate goal of lymphedema therapy is the targeted and individualized treatment. New technology of multimodality lymphatic imaging emerged in the recent years largely improves the diagnosis of lymphatic circulation disorders. The treatment of peripheral lymphedema is expected to have new achievement. This book illustrates the latest achievements in clinical and basic research of lymphedema to the clinical investigators as well as basic researchers. Pathogenesis of lymphatic system, diagnosis of lymphedema, treatment and further complication management are demonstrated in this book. Some special lymphedema related syndromes, issues on prevention and prognosis are also included.

Contents:
Part 1 Overview of lymphatic system
1 Physiology of lymphatic system (physiology of capillary filtrate flow to lymphatics)
2 Anatomy of lymphatic system
3 Formation and transport of lymph
4 Function of the lymphatic system
Part 2 Lymphedema
5 Introduction
6 Etiology of primary lymphedema
7 Secondary lymphedema of different types
8 Stage of lymphedema
Part 3 Pathogenesis of lymphatic system in lymphedema
9 Changes in lymphatic vessels in primary lymphedema
10 Changes in lymph node in primary lymphedema
11 Pathology of collecting lymph vessels in secondary lymphedema
12 Pathology of the initial lymph vessels in lymphedematous skin
13 Co-malformations of venous and lymphatic vessels in primary lymphedema
Part 4 Pathology of lymphedematous tissue
14 Lymphedema fluid
15 Inflammation
16 Tissue overgrowth in lymphedema
Part 5 Diagnosis of lymphedema - Assistant in diagnosis
17 Clinical diagnosis and differential diagnosis
18 MR lymphangiography (MRL)
19 Nuclear Medicine imaging in the diagnosis of Peripheral lymphedema : Lymphoscintigraphy
20 Indocyanine green lymphography
21 Nuclear Medicine imaging in the diagnosis of Peripheral lymphedema : Single-Photon Emission Computed Tomography/Computed Tomography(SPECT/CT)
22 Comparison of current imaging methods in diagnosis of peripheral lymphedema
Part 6 Treatment of lymphedema - conservative treatment
23 Compression Therapy
24 Complex Physical Decongestive Therapy for Lymphedema (CDT)
25 Far infrared radiation thermotherapy
Part 7 Treatment of lymphedema - Surgical treatment
26 Suction Assisted Lipectomy with simultaneous skin excision for lymphedema
27 Microsurgery - Vascularized Lymph Vessel Transfer
28 Microsurgery - Lymphaticovenular anastomosis for the treatment of lymphedema
29 Microsurgery - Lymph node/flap transplantation
30 Microsurgery - Lymphatic Tissue Transfer for the Treatment of Axillary Dissection Related Lymphedema
31 Silicone tube implantation
32 Liposuction
Part 8 Curative effect assessment
33 Circumference measurement
34 Bioelectrical impedance analysis
35 Skin fibrometer and Lymph Scanner
Part 9 Lymphedema in children
36 Lymphedema in childhood
Part 10 Prevention of tumor treatment related lymphedema
37 Prevention of lymphedema after breast cancer surgery
38 Prevention of pelvic malignancies and related lymphedema.

Contents:
Part I. Peripheral nerve entrapments: general principles
Part II. Headache
Part III. Facial and cervical nerve entrapments
Part IV. Chest wall peripheral nerve entrapment syndromes
Part V. Upper extremity peripheral nerve entrapments
Part VI. Abdominal wall pain
Part VII. Pelvic pain
Part VIII. Low back pain
Part IX. Lower extremity
Index
Index of symptoms.

Summary: Peripheral nerve issues are potential sequalae of orthopedic surgery, even after cases in which technically excellent surgery was performed. These injuries can impede the expected recovery of function after the primary surgery. Given the manifold challenges associated with recovery of peripheral nerve injuries, this book is designed as a multidisciplinary guide to the diagnosis, prognostication and treatment of peripheral nerve issues after common orthopedic surgeries. Beginning with an overview of nerve compression, injury and regeneration, as well as a presentation of the current diagnostic and imaging modalities for peripheral nerve injuries, this unique text is organized by anatomic region and by type of procedure performed. Topics covered include shoulder and elbow arthroplasty and arthroscopy, fractures of the hand and wrist, hip preservation surgery, total knee replacement, open surgery of the foot and ankle, lumbosacral myeloradiculopathy, and more. Each chapter is authored by both a subspecialty surgeon who routinely performs the surgeries described and a subspecialized hand/peripheral nerve surgeon with experience in evaluating and treating nerve issues after that particular injury. Emphasis is placed on multidisciplinary team approaches, patient counseling, and technical aspects of surgical treatment. Generously illustrated and written by experts in the field, Peripheral Nerve Issues after Orthopedic Surgery is a truly interdisciplinary resource for orthopedic, plastic, hand and trauma surgeons, physiatrists, and all professionals managing postoperative peripheral nerve pain.

Contents:
Nerve Compression, Nerve Injury, and Nerve Regeneration: An Overview
Evaluation of the Patient with Postoperative Peripheral Nerve Issues
Nerve Injury after Shoulder Arthroscopy, Stabilization, and Rotator Cuff Repair (axillary, musculocutaneous, suprascapular nerves)
Nerve Injury after Shoulder Arthroplasty
Nerve Injury after Humerus, Elbow, and Forearm Fractures (radial, posterior interosseous, and ulnar nerves)
Nerve Injury Associated with Elbow Procedures
Nerve Injury after Distal Radius, Metacarpal and Finger Fractures
Median and Ulnar Nerve Injury at the Elbow and Wrist
Pelvic, Acetabular, Hip, and Proximal Femur Fractures: Intra-pelvic and Extra-pelvic Neuroanatomy
Pelvic, Acetabular, Hip, and Proximal Femur Fractures: Surgical Exposures and Treatment of Nerve Injury
Nerve Injury after Total Hip Arthroplasty
Nerve Injury after Hip Arthroscopy, Hip Preservation Surgery, and Proximal Hamstring Repair
Nerve Injury after Distal Femur, Tibial Plateau, and Tibial Shaft Fractures
Nerve Injury after Total Knee Arthroplasty
Nerve Injury after Knee Arthroscopy, ACL Reconstruction, Multiligament Knee, and Open Knee Surgery
Nerve Injury after Distal Tibia, Pilon, and Ankle Fractures
Nerve Injury after Fractures of the Hindfoot, Midfoot, and Forefoot
Nerve Injury after Open and Arthroscopic Surgery of the Ankle and Foot, Including Morton Neuroma
Lumbosacral Double Crush Syndrome.

Summary: At last—a single, convenient reference on this interventional pain management technique, covering all recent advances in this fast-changing field. Peripheral Nerve Stimulation: A Comprehensive Guide is a one-stop resource offering practical guidance on performing a wide array of pain-relieving procedures using office-based ultrasound-guided techniques, fluoroscopy, and more. Concise and user-friendly, this easy-to-use guide helps physicians deliver safe, accurate, and cost-effective care by demonstrating how to evaluate the causes of pain, identify the most promising stimulation technique, locate the site with precision, and provide effective pain relief.

Contents:
History of Peripheral Nerve Stimulation for Pain
Peripheral Nerve Entrapments
Mechanism of Action of Peripheral Nerve Stimulation
Ultrasound Versus Fluoroscopy
Surgical Tools For Peripheral Nerve Stimulation
Surgical Techniques For Peripheral Nerve Stimulation
Peripheral Nerve Stimulation Education and Psychological Evaluation
Occipital Nerve Stimulation
Trigeminal Nerve Peripheral Nerve Stimulation
The Sphenopalatine Ganglion: Associated Illnesses and Therapeutic Modalities
Axillary and Suprascapular Nerves
Brachial Plexus
Ulnar Nerve
Median Nerve
Radial Nerve
Intercostal Nerves
Ilioinguinal and Iliohypogastric Nerve
Genitofemoral Nerve
Superior Cluneal Nerves
Middle Cluneal Nerves
Inferior Cluneal Nerve
Pudendal Peripheral Nerve Stimulation For Chronic Pelvic Pain
Lateral Femoral Cutaneous Nerve
Femoral Nerve
Sciatic Nerve
Genicular Peripheral Nerve Stimulation
Peroneal Nerves (Fibular Nerves)
Saphenous Nerve
Posterior Tibial Nerve
Sural Nerve
Superior Gluteal Nerve
Craniofacial Stimulation and Headache
Peripheral Nerve Stimulation for Complex Regional Pain Syndrome
Postherpetic Neuralgia
Approach to Low Back Pain and Peripheral Nerve Stimulation
Peripheral Nerve Stimulation for Chronic Pelvic Pain
Postamputation Pain
Peripheral Neuropathy
Overactive Bladder
Gastric Stimulation For Gastroparesis
Motor Stimulation
Vagal Nerve Stimulation.

Summary: Do you find the evaluation of a patient presenting clinical symptoms of distal extremity numbness and weakness daunting and complex? Are you unsure of the diagnostic processes and best-practices in the treatment of peripheral neuropathy? This invaluable guide presents a practical approach to the diagnosis and successful management of patients with peripheral neuropathies. Starting with a structured series of patient queries for symptoms and examination signs, the diagnostic process emphasizes the role of electrodiagnostic tests in defining the neuropathy. Specific neuropathies are presented with their epidemiology, causative pathology, diagnostic and laboratory factors, alongside advised treatments and overall management strategies. This leading resource will assist non-neuromuscular neurologists, physiatrists, neurology and physiatry residents, and will also be useful to electromyographers, proving an ideal aid for busy clinic schedules.

Summary: This book provides an illustrated guide to peripheral retinal degenerations and the role of spectral domain coherence tomography (SD-OCT) in diagnosis and treatment. The book discusses 73 clinical cases and gives detailed information on the principles of SD-OCT and its application in the imaging of peripheral retina. Peripheral Retinal Degenerations: Optical Coherence Tomography and Retinal Laser Coagulation, 2nd edition, discusses a broad range of retinal pathologies such as chorioretinal degenerations, posterior vitreous detachment, vitreoretinal adhesions and tractions and includes a plethora of high-quality clinical images throughout. Ophthalmologists and retinal specialists will find this updated edition to be the perfect didactic resource for furthering skills and knowledge in this clinical area.

Contents:
Principles and methods of peripheral retina OCT scanning
Optical coherence tomography of the peripheral retina and the vitreoretinal interface
Peripheral retinal degenerations as a risk factor for rhegmatogenous retinal detachment
Intraretinal degenerations
Vitreoretinal degenerations
Chorioretinal degenerations
Retinal laser photocoagulation in peripheral degenerations.

Summary: "The immune system can be classified into 2 basic component: (1) the innate immune system, and (2) the acquired immune system. The innate immune system is considered to be relatively agnostic to any specific antigen, and is often described as invariant. The innate immune response is the first line of defense, and typically exhibits limited specificity. Examples of innate immune response may include phagocytosis by macrophases, barriers to infect provided by the skin and tears, NK- and mast cells, and complement mediated cytolysis. In contrast, the adaptive (or sometimes called acquired) immune response develops in response to specific antigen, being 'custom' designed for the antigen in question, usually occurs later in the immune response, and has the ability to recall the response to past infections. Components of a functioning acquired immune response might involve antigen presenting cells presenting antigen ot T-cells, the activation of specific T-cells which would signal to B-cells enlisting their engagement in the response and the production of highly specific antibody capable of binding specific antigen. T- and B- lymphocytes are the major types of lymphocytes found in the human body, where they can constitute 20-40% of all white blood cells, with only about 2-3% of these being found in the peripheral circulation, the remainder being localized to various lymphoid organ is (lymph nodes, spleen, submucosal tissue). Remarkably, the total mass of lymphocytes in the body can approximate the mass of the brain and liver"-- Provided by publisher.

Contents:
Fundamentals T-Cell Lymphocyte Biology / Claudio Tripodo, Stefano Pilleri
Mechanisms of T-Cell Lymphomagenesis / François Lemonnier, Philippe Gaulard, Laurence de Leval
Epigenetics of T-Cell Lymphoma / H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen O'Connor, Sean Harrop
Animal Models of T-Cell Lymphoma / Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe, Mamiko Sakata-Yanagimoto
The Geographic Distribution of the PTCL : Global Epidemiology / Amulya Yellala, Avyakta Kallam, James Armitage
Classification of the Peripheral T-Cell Lymphomas / Neval Ozkaya, Elaine Jaffee
Molecular Classification of the PTCLs / Tyler A. Herek, Javed Iqbal
Peripheral T-Cell Lymphoma
Not Otherwise Specified / Nora Bennani, Stephen Ansell
Angioimmunoblastic T-Cell Lymphoma (AITL) / Jehan Dupuis, Franck Morschhauser
The Spectrum of Anaplastic Large Cell Lymphoma / Jianping Kong, Andrew Feldman
HTLV-1-Positive Adult T-Cell Leukemia-Lymphoma (ATL) / Wataru Munakata, Kensei Tobinai
Natural Killer/T Cell Lymphomas / S.J. Kim, R. Suzuki, A. Jaccard, S.T. Lim, Won Seog Kim
T-Prolymphocytic Leukemia (T-PLL) / Dima El-Sharkawi, Claire Deardon
Large Granular Lymphocytes Leukemia (LGL) / Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith, Thomas P. Loughran, Jr. Gamma Delta T-Cell Lymphomas / Francine Foss, Aadil Ahmed, Mina Xu
Enteropathy Associated T-Cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma / Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave, Govind Bhagat
Hepatosplenic T-Cell Lymphomas / Robert N. Stuver, Mwanasha Merrill, Salvia Jain
Cutaneous T-Cell Lymphoma / Alejandro Ariel Gru, Bethanie Rooke, Kevin Molloy, Julia Scarsbrick
Other Rare Subtypes of PTCL / Pier Paolo Picaluga
Standard Front-line Therapies / Raphael Koch, Lorenz Truemper
Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab Vedotin / Helen Ma, Owen A. O'Connor
The Role for Autologous Stem Cell Transplantation (ASCT) in Peripheral T Cell Lymphomas (PTCL) / Juan Alejandro Ospina, H. Martinez-Cordero, J. Enciso, H. Idrobo
Allogeneic Stem Cell Transplantion / Anna Dodero, Paolo Corradini
Emerging Immunotherapy Approaches in Peripheral T-Cell Lymphomas / Barbara Pro, Andrei Shustov
Emerging New Small Molecules in Peripheral T-Cell Lymphomas / Alessandro Broccoli, Pier Luigi Zinzani
The Value and Relevance of T-Cell Lymphoma Registries / Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok, Massimo Federico
Innovative Chemotherapy-Free Approaches for the Treatment of PTCL / Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto, Francesca Montanari
Global Collaborations / Dejan Radjeski, Eliza Hawke, Owen A. O'Connor, Pier Luigi Zinzani, WonSeog Kim, Enrica Marchi.

Summary: Indications for central venous cannulation in critically ill patients have increased dramatically in recent years owing to the use of more complex therapies unsuitable for delivery via peripheral veins. The main drawbacks of central venous access are morbidity and the growing scarcity of experienced operators. Ultrasound-guided peripheral venous access offers a solution, in that it reduces morbidity and can be performed by a dedicated nursing team. The aim of this book is to teach the fundamentals of this emerging technique. Advice is provided on the choice of materials and on vein selection. The advantages and disadvantages of peripherally inserted central venous catheters (PICC) in relation to other types of central venous catheter are discussed, and the principles of use and practical applications of ultrasound for venipuncture are explained. Maneuvers for PICC positioning, techniques for the evaluation of PICC tip placement, and the prevention, diagnosis, and management of complications are all described in detail. Advice is also provided on the organization of a dedicated PICC team within a hospital or a supportive care program, and psychological, legal, and economic issues are considered. Peripherally Inserted Central Venous Catheters will be of interest to a wide range of professionals, including nutritionists, oncologists, anesthesiologists, surgeons, registered nurses, nurse practitioners, physicians, physician assistants, and radiologists.

Contents:
Introduction and Overview of PICC History
Which Material and Device? The Choice of PICC
Vessel Health and Preservation: The Proactive Approach
The Choice of a Vein in Critically Ill Patients: Cost-Effectiveness
Advantages, Disadvantages, and Indications of PICCs in Inpatients and Outpatients
Ultrasound Anatomy of Peripheral Veins and Ultrasound-Guided Venipuncture
Evaluation Techniques of the PICC Tip Placement
Frequency, Diagnosis, and Management of Occlusive and Mechanical PICC Complications
Clinical Problems Associated with the Use of Peripheral Venous Approaches: Infections
Clinical Problems Associated with the Use of Peripheral Venous Approaches in Clinical Practice: Thrombosis
Maneuvers, Precautions, and Tricks for PICC Positioning Procedure
The "Off-Label" Use of PICCs
Venous Access Devices and Emotional Response in Oncologic Patients: Diagnostic and Management Aspects
Peripheral Inserted Central Catheters: Medicolegal Aspects
The PICC Team.

Summary: Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

Contents:
Epidemiology of Total Hip and Knee Arthroplasty Infection
Risk Factors for Periprosthetic Joint Infection
Prevention of Periprosthetic Joint Infection
Medical Optimalization of Patients Prior to Surgery
Diagnosis of Periprosthetic Joint Infection: An Algorithmic Approach to Patients
Intraoperative Tests to Aid in Diagnosis of Periprosthetic Joint Infection
Biofilm-Related Periprosthetic Joint Infection
Microbiology of Periprosthetic Joint Infection
Antibiotics in Treatment of Periprosthetic Joint Infection
PMMA and Antimicrobial Delivery
Prosthetic Retention: Treatment Options
Single-Stage Exchange for Treatment of Periprosthetic Joint Infection
Two-Stage Exchange Hip Arthroplasty: Static Spacers
Two-Stage Exchange Hip Arthroplasty: Articulating Spacers
Two-Stage Exchange Knee Arthroplasty: Static Spacers
Two-Stage Exchange Knee Arthroplasty: Articulating Spacers
Knee Arthrodesis
Resection Arthroplasty and Hip Joint Fusion
Above-Knee Amputation
Post-Operative Management of Periprosthetic Joint Infection.

Contents:
Part I. Incidence and Socioeconomic Impact
Part II. Prevention of Periprosthetic Joint Infection
Part III. Diagnosis of Periprosthetic Joint Infection
Part IV. Local Antibiotic Therapy
Part V. The Hip Joint
Part VI. The Knee Joint
Part VII. Perioperative Optimization
Part VIII. Long-term Perspectives
Part IX. Future Approaches.

Contents:
Anatomy and physiology of the peritoneum / Krediet, R.T.
Treatment modalities / Struijk, D.G.
Access- and catheter-related complications / Struijk, D.G.
Measurement of peritoneal transport / Krediet, R.T.
Assessment of the peritoneum by biomarkers in peritoneal effluent / Krediet, R.T.
Peritonitis and other catheter-related infections / Esch, S. van
Information technology in peritoneal dialysis / Struijk, D.G.
Residual renal function and peritoneal dialysis dose in adequacy of peritoneal dialysis / Krediet, R.T.
Peritoneal dialysis solutions / Krediet, R.T.
Long-term peritoneal dialysis and encapsulating peritoneal sclerosis / Krediet, R.T.

Contents:
1. Anatomy of Peritoneum and Preoperative Assessment of Patients with Peritoneal Surface Malignancies
2. Surgical Technique for Cytoreductive Surgery
3. Intraperitoneal Chemotherapy Applications
4. Management of Special Issues
5. Molecular Mechanism of Peritoneal Metastases.

Summary: This book provides surgeons and oncologists with a well-founded and detailed overview of the available treatment options for peritoneal malignancy and differential selection of the appropriate forms of therapy. Systemic chemotherapy options are also considered, as are surgical cytoreduction (CRS) and all forms of intraperitoneal chemotherapy (IPC) especially hyperthermic IPC (HIPEC), and immunotherapy, including specific procedures such as PIPAC. Subsequent chapters address perioperative care, complications and recurrences, as well as psycho-oncological, palliative medical and nursing care. The process of parietal and visceral peritonectomy in the large and small intestine is additionally illustrated by three video clips accessible online. Covering a broad range of aspects, including peritoneal metastasis and intraperitoneal chemotherapy, the book offers a valuable tool for surgeons, oncologists and anesthesiologists alike.

Summary: Covering the full spectrum of CHD from infants through adults, Perloff's Clinical Recognition of Congenital Heart Disease, 7th Edition, provides unparalleled guidance on the diagnosis and treatment of common and uncommon CHD in one definitive resource. The editors of this new edition, Drs. Ariane J. Marelli and Jamil A. Aboulhosn, have maintained Dr. Joseph Perloff's richly nuanced approach while bringing this classic text completely up to date with all the latest evidence and technologic advances in the field. With its comprehensive, step-by-step approach, you'll acquire a structured understanding of CHD across age ranges, allowing you to effectively detect these conditions as early as possible. NEW in the 7th Edition: Updated images throughout, as well as phonocardiograms, electrocardiograms, flow charts, and anatomic drawings Specific, integrated findings for individual patients with Dr Perloff's classic approach to diagnosis and treatment Streamlined review of sequelae and complications Historical Notes at the beginning of each chapter Tips on selecting among the increasing array of currently available procedures, helping foster and develop clinical judgment skills Update on genetic contributions to clinical recognition for a more complete presentation of patient diagnosis. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Summary: This unique book is a practical, "go to" source of comprehensive information on the care of peroneal tendon injuries, accurately illustrating this hot topic with many anatomical drawings of how the anatomy influences the diseases we see clinically. This presentation opens with a review of the normal anatomy, biomechanics and examination of the peroneal tendons, followed by a discussion of congenital variations and imaging strategies used in diagnosis and evaluation. Both conservative and surgical management techniques are then elucidated in injury-specific chapters, from peroneus brevis splits and stenosing tenosynovitis to painful os peroneum syndrome (POPS) and acute dislocation. Chapters on rehabilitation and comorbid pathologies round out the presentation. The diagnosis of peroneal tendon injury is much more common today than it was 20 years ago. Utilizing the latest evidence and presenting the most cutting-edge management techniques, The Peroneal Tendons will be useful for orthopedic and podiatric surgeons, sports medicine specialists, and students and residents in these areas.

Contents:
Normal Anatomy and Physical Examination of the Peroneal Tendons
Biomechanics of the Peroneal Tendons
Congenital Variations of the Peroneal Tendons
Imaging of the Peroneal Tendons
Conservative Treatment of the Peroneal Tendons
Peroneal Brevis Splits
Peroneal Brevis Splits Associated with Chronic Lateral Ankle Instability
Stenosing Tenosynovitis along the Lateral Wall of the Calcaneus
Painful Os Peroneum Syndrome (POPS)
Attritional Rupture of the Peroneal Tendons
Acute Subluxation/Dislocation of the Peroneal Tendons
Immobilization and Rehabilitation of the Peroneal Tendons
Peroneal Tendon Pathology Associated with the Cavovarus Foot
Peroneal Tendon Pathology Associated with Calcaneous Fractures.

Summary: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.

Contents:
[II]. Peroxisomal diseases : biological characteristics and diagnosis: Peroxisome biogenesis disorders / Masanori Honsho, Kanji Okumoto, Shigehiko Tamura, Yukio Fujiki
Fatty acid oxidation in peroxisomes : enzymology, metabolic crosstalk with other organelles and peroxisomal disorders / Ronald J. A. Wanders, Frédéric M. Vaz, Hans R. Waterham, Sacha Ferdinandusse
Zellweger syndrome disorders : from severe neonatal disease to atypical adult presentation / David Cheillan
Heimler syndrome / S. Mechaussier, I. Perrault, H. Dollfus, A. Bloch-Zupan, N. Loundon, L. Jonard et al. [IV]. Cell and animal model systems: A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders / Yuichi Abe, Shigehiko Tamura, Masanori Honsho, Yukio Fujiki
The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy / Margret H. Bülow, Brendon D. Parsons, Francesca Di Cara
Human peroxisomal 3-ketoacyl-CoA thiolase : tissue expression and metabolic regulation / Norbert Latruffe. [V]. Treatment of peroxisomal diseases: Biological functions of plasmalogens / Md Shamim Hossain, Shiro Mawatari, Takehiko Fujino
Therapeutic efficacy of plasmalogens for Alzheimer's disease, mild cognitive impairment, and Parkinson's disease in conjunction with a new hypothesis for the etiology of Alzheimer's disease / Takehiko Fujino, Md Shamim Hossain, Shiro Mawatari.

Summary: This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Contents:
Part 1 Biogenesis and Function of peroxisome
1 The history of peroxisomal research
2 Peroxisome Biogenesis
3 Peroxisome Degradation and Its Molecular Machinery
4 The function of the peroxisome
Part 2 Dysfunction of Peroxisome and Human Disease
5 Peroxisomal disorders
6 Model organisms used to understand peroxisomal disorders
7 Diagnosis of peroxisomal disorders
8 Therapeutic strategies for X-linked adrenoleukodystrophy, a representative peroxisome disease
Part 3 Topics in Peroxisome Research
9 The isolation of peroxisomes
10 Structure Biology of peroxisomal proteins, peroxins
11 Lipidomics of peroxisomal disorders
12 Neurophysiology and neuropsychology for X-ALD.

Summary: This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

Contents:
Intro; Introduction; Contents; Contributors;
Chapter 1: Evolution Under Antibiotic Treatments: Interplay Between Antibiotic Persistence, Tolerance, and Resistance; 1.1 Distinguishing Between Resistance, Tolerance, and Antibiotic Persistence; 1.1.1 Antibiotic Resistance; 1.1.2 Antibiotic Tolerance; 1.1.3 Antibiotic Persistence; 1.1.4 Different Types of Persistent Bacteria; 1.1.4.1 Triggered Persistence [Previously Called Type I (Balaban et al. 2004)]; 1.1.4.2 Spontaneous Persistence [Previously Called Type II (Balaban et al. 2004)]; 1.2 Quantification of Antibiotic Tolerance and Persistence 1.3 Evolution of Antibiotic Tolerance Under Intermittent Antibiotic Treatments1.3.1 Tolerance and Persistence-by-Lag Evolve to Match the Duration of the Antibiotic Treatment; 1.3.2 Evolution of Stationary Phase Triggered Antibiotic Persistence; 1.3.3 Evolution of Drug-Induced Tolerance; 1.3.4 Antibiotic Tolerance in the Clinic; 1.3.4.1 Evolution of Tolerance in the Clinic; 1.3.4.2 Techniques to Detect Tolerance in the Clinic; 1.4 Antibiotic Tolerance and Persistence Promote the Evolution of Resistance; 1.5 Conclusion; References 2.3.2.1 The Mesenteric Lymph Nodes and Spleen Are Preferred Niches for Antibiotic-Tolerant S. Typhimurium During Infection2.3.2.2 The Subpopulation of S. Typhimurium Capable of Surviving Antibiotic Treatment During Infection Are Slow or Non-Growing ... ; 2.4 Molecular Mechanisms: How to Cope with Combined Host and Antibiotic Challenges?; 2.4.1 Formation of Salmonella Antibiotic Persisters During Infection; 2.4.2 Salmonella Antibiotic Persisters Must Survive the Immune Response During Infection; 2.5 Going Forward: Future Directions and Challenges; References
Chapter 2: Antibiotic Persisters and Relapsing Salmonella enterica Infections2.1 Persistence of Infection, Antibiotic Persistence, and Antibiotic Persistence During Infection: What Is the Difference?; 2.2 A Brief Introduction to Salmonella enterica Infections; 2.3 Evidence for Role of Antibiotic Persistent Salmonella in Relapsing Infections; 2.3.1 Clinical Evidence for Antibiotic Persistence During Infection in Humans; 2.3.2 Experimental Evidence for Antibiotic Persistence During Infection in Mice
Chapter 3: The Biology of Persister Cells in Escherichia coli3.1 Basic Concepts of Persister Cell Biology; 3.1.1 Persister Formation as a Phenotypic Switch into Dormancy; 3.1.2 Stochasticity and Heterogeneity of Persister Formation; 3.1.3 Biological Functions of Persister Cells; 3.2 Unraveling the Genetic Basis of Persister Formation; 3.2.1 Conceptual Overview; 3.2.2 Distinguishing Persister Formation/Survival from Phenotypic Resistance; 3.3 Non-Specific Mechanisms of Persister Cell Formation; 3.3.1 Energy Metabolism and Oxygen; 3.3.2 PASH: ``Persistence as Stuff Happenś́

Summary: The book revisits the causes of persisting undernutrition in India, but moves away from the usual focus on women and children to a broader view of the entire population. It estimates the economic losses resulting from ignoring undernutrition in the adult working population, and questions the current narrow focus of nutrition interventions, suggesting that a family-based approach may provide quicker results and long-term sustainability. It compares the best and worst performing states in the country to glean learnings from both successes and failures and emphasizes the need to hand over the ownership of nutrition outcomes from the state to the community and family for more sustainable results. The book is organized in three sections: Part 1 details the nutrition status of the population, regional variations in nutrition outcomes, and government response in terms of interventions. Part 2 reviews issues and concerns like gender discrimination, poor child nutrition status, ineffective implementation of government programmes in the field, and the possible impacts of emerging issues like climate change. Part 3 seeks solutions from both international and country experiences.

Contents:
Person-centredness in healthcare policy, practice and research / Brendan McCormack, Sandra van Dulmen, Hilde Eide, Kirsti Skovdahl, and Tom Eide
Philosophical perspectives on person-centredness for healthcare research / Jan Dewing, Tom Eide and Brendan McCormack
The knowing and being of person-centred research practice across worldviews : an epistemological and ontological framework / Angie Titchen, Shaun Cardiff, and Stian Biong
Being a person-centred researcher : principles and methods for doing research in a person-centred way / Gaby Jacobs, Famke van Lieshout, Marit Borg, and Ottar Ness
Research into person-centred healthcare technology : a plea for considering humanisation dimensions / Gaby Jacobs, Teatske van der Zijpp, Famke van Lieshout, and Sandra van Dulmen
A participatory approach to person-centred research : maximising opportunities for recovery / Larry Davidson, Chyrell Bellamy, Elizabeth Flanagan, Kimberly Guy, and Maria O'Connell
Co-creating flourishing research practices through person-centred research : a focus on persons living with dementia / Kirsti Skovdahl and Jan Dewing
Leadership research : a person-centred agenda / Tom Eide and Shaun Cardiff
Staffing structures for effectiveness in person-centred care : the rafaela system / Lisbeth Fagerström
Giving voice to 'hard to reach groups' in healthcare research : a narrative approach / Catherine Buckley
Promoting health across the lifespan : a systems approach / Elisabeth Fosse, Steffen Torp, and Ingun Stang
How knowledge developed through ethnography may inform person-centred healthcare practices / Kristin Briseid, Astrid Skatvedt and Brendan McCormack
Person-centred technology-supported interventions / Sandra van Dulmen, Espen Brembo, Janne Dugstad, and Hilde Eide
Learning to be an effective person-centred practitioner / Caroline Williams and Brendan McCormack
Doing eye and vision research in a person-centred way / Rigmor C. Baraas, Lene A. Hagen, Hilde R. Pedersen, and Jon V. B. Gjelle
Person-centred communication research : systematic observation of real life practice / Hilde Eide, Linda Hafskjold, Vibeke Sundling, and Sandra van Dulmen
Introducing sex and gender-sensitive person-centred healthcare research / Stina Öresland and Sylvia Määttä
Future directions for person-centred healthcare research / Sandra van Dulmen, Brendan McCormack, Hilde Eide, Kirsti Skovdal, and Tom Eide.

Summary: This book is the first ever to offer a contemporary collection of different perspectives on person-centredness in international doctoral nursing research. The research in the book is based on the ideas and values of personhood and person-centeredness, which have been used and can be seen to guide research approaches, inform research designs and theorize research findings. Further, a specific framework for person-centred nursing is embedded throughout the research studies presented in the text. The Person-centred Nursing Framework (PCNF) developed by Brendan McCormack and Tanya McCance in 2010, is recognized as a nursing theory and this book further develops it as a basis for research and for advancing person-centredness in nursing. The framework informs all stages of the research process, from design through to dissemination. The book is structured into a number of highly engaging chapters written by doctoral candidates, and recently graduated candidates. The opening and closing chapters, written by the editors, place the subsequent chapters in a global context of person-centredness and nursing. The potential for person-centred nursing research to be a global movement is recognized and debated. The subsequent chapters lead readers through philosophical ideas, methodologies and methods whilst also offering reflective and honest insights into learning how to become a person-centred researcher. This field is growing and developing but yet there is no specific book available. As a result, researchers spend considerable time and effort translating existing research methodologies into person-centred perspectives. This book fills this gap and acts as a key resource for future nurse researchers. The text is intended for, and benefits nursing doctoral candidates, masters candidates and academic staff who teach and supervise research candidates; it may also appeal to other graduate learners. The book has international contributions which makes it appealing internationally.

Contents:
Introduction
Chapter 1. Person-centred Nursing Research Principles
Chapter 2. The Person-centred Nursing Framework and Nursing Research
Chapter 3. Coming to know Personhood: philosophical 'dates'
Chapter 4. Overviews of person-centered research: selected specific research examples.
Chapter 5. Developing theoretical frameworks: integrating specific values and principles into research
Chapter 6. Methodologies for Person-centred Nursing Research
Chapter 7. Knowing how to act
person centred research methods
Chapter 8. Knowing, Being and Becoming in person-centred research (action research chapter).
Chapter 9. Phenomenological and hermeneutic approaches
Chapter 10. Experimentation and Quasi- experimentation in person-centred research
Chapter 11. Multiple and mixed methods approaches
Chapter 12. Person-centredness in education research
Chapter 13. Adopting a person-centred approach in doctoral supervision
Chapter 14. Summary chapter: facing the future with confidence.

Summary: This book clarifies consumer and personal health informatics and their relevance to precision medicine and healthcare applications. Personal Health Informatics covers a broad definition of this emerging field, with individuals not simply consuming health but as active participants, researchers and designers in the healthcare ecosystem. The world of health informatics is constantly changing given the ever-increasing variety and volume of health data, care delivery models that shift from fee-for-service to value-based care, new entrants in the ecosystem and the evolving regulatory decision landscape. These changes have increased the importance of the role of patients in research studies for understanding work processes and activities, and the design and implementation of health information systems. Therefore, personal health informatics now provide research tools and protocols to engage within individual contexts when developing solutions, which can improve clinical practice, patient engagement and public health. Personal Health Informatics offers a snapshot of this emerging field, supported by the methodological, practical, legal and ethical perspectives of researchers and practitioners. In addition to being a research reader, this book provides pragmatic insights for practitioners in designing, implementing and evaluating personal health informatics in healthcare settings. It represents an excellent reader for students in all clinical disciplines and biomedical and health informatics to learn from the case studies provided in this emerging field.

Contents:
Intro
Foreword
Preface
Overview
Section I: The State-of-the-Art Novel Care Delivery Models
Section II: Methods for Translating Biomedical Research and Real-World Evidence into Patient-Centric Precision Health Application
Section III: Methods for Patient-Centric Design
Section IV: Ethics, Bias, Privacy, and Fairness
Acknowledgment
Contents
About the Editors and Contributors
About the Editors
About the Contributors
Part I: The State-of-the-Art Novel Care Delivery Models
Chapter 1: E-enabled Patient-Provider Communication in Context
Introduction Case Example #1: Development of the E-Health Care Model and Implementation in the PreClinic in Denmark
Evaluation of ECM Accomplishments
Case Example #2: Task-Sharing Mental Health Primary Care Delivery Model Via Smart Phones in Pacific Island Countries
The Study
Summary of Results
Challenges and Opportunities
Future Directions
Case Example #3: Colombia: Prenatal Care and Early Risk Identification
A Systems Model for E-Health Enabled Collaborative Care Delivery
Collaborative Care Delivery in the Time of COVID-19
Lessons on Collaborative Care Delivery from COVID-19 Discussion
References
Chapter 2: Direct Primary Care: A New Model for Patient-Centered Care
Primary Care, the Patient-Centered Medical Home, and Direct Primary Care
Primary Care
Patient Centered Medical Home
Direct Primary Care
Accreditation Process
Experience of the Patient and Provider
The Patient-Provider-Payer Shift
The Implications for DPC in Practice
Mixed Methods Research Methodology
Qualitative Methods
Quantitative Methods
Data Types
Data Quality
Results
Timely Access
Effectiveness
Patient-Centered
Efficiency/Affordability Conclusions, Implications, and Future Directions
References
Chapter 3: Smart Homes for Personal Health and Safety
Introduction
Sense4Safety: Using Smart Home Technology to Reduce Fall Risk
Falls and MCI as Significant Public Health Problems
Rationale for Passive In-Home Sensing
Use of Passive Monitoring Technology for Early Detection of Functional Changes
The Sense4Safety Intervention
Ethical Implications
Conclusion
References
Chapter 4: Health App by Prescription: The German Nation-Wide Model
Introduction
Overview
German Healthcare System Licensing and Marketing Authorization
Reimbursement by the Statutory Health Insurance (SHI)
New Digital Services in the German Healthcare System
Electronic Health Card and Personal Health Records (2000-2020)
Digital Health Applications (Since 2020)
First Experiences with DiGAs
Acceptance and Knowledge About DiGA Among German Healthcare Professionals and Citizens
DiGA as a New Business Model for Healthcare Start-ups and New Strategic Partnerships
Conclusion
Glossary
References

Summary: "The remarkable, little-known story of Belle da Costa Greene, J. P. Morgan's personal librarian-who became one of the most powerful women in New York despite the dangerous secret she kept in order to make her dreams come true, from New York Times bestselling author Marie Benedict and acclaimed author Victoria Christopher Murray. In her twenties, Belle da Costa Greene is hired by J. Pierpont Morgan to curate a collection of rare manuscripts, books, and artwork for his newly built Morgan Library. Belle becomes a fixture on the New York society scene and one of the most powerful people in the art and book world, known for her impeccable taste and shrewd negotiating for critical works as she helps build a world-class collection. But Belle has a secret, one she must protect at all costs. She was born not Belle da Costa Greene but Belle Marion Greener. She is the daughter of Richard Greener, the first Black graduate of Harvard and well-known advocate for equality. Belle's complexion isn't dark because of her alleged Portuguese heritage that lets her pass as white-her complexion is dark because she is African American. The Personal Librarian tells the story of an extraordinary woman, famous for her intellect, style, and wit, and shares the lengths she must go-for the protection of her family and her legacy-to preserve her carefully crafted white identity in the racist world in which she lives"-- Provided by publisher.

Summary: Practitioners are increasingly adopting a personalised medicine approach to individually tailored patient care, especially disease diagnosis and treatment with the use of biomarkers. However, development and implementation of such approaches to chronic disease prevention need further investigation and concerted efforts for proper use in healthcare systems. This book provides high-quality, multidisciplinary knowledge from research in personalised medicine, specifically personalised prevention of chronic disease. It addresses different perspectives of prevention in the field, and is the outcome of a four-year work of the Personalized prevention of Chronic Disease (PRECeDI) Consortium, a multi-disciplinary and multi-professional team of experts. The Consortium jointly agreed to document and address the five aspects or domains of personalised medicine and prevention as individual chapters: Identification of biomarkers for the prevention of chronic disease Evaluation of predictive genomic applications Ethico-legal and policy issues surrounding personalised medicine Roles and responsibilities of stakeholders in informing healthy individuals on their genome: a sociotechnical analysis Identification of organisational models for the provision of predictive genomic applications The book focuses on the Consortium's recommendations that are derived from each of these domains based on up-to-date evidence and research that the authors write, follow, and systematically organise and report. Personalisation of health care is, eventually, a driver of innovation in research and healthcare systems. With this SpringerBrief on Personalised Health Care: Fostering Precision Medicine Advancements for Gaining Population Health Impact, the Consortium provides further evidence of the clinical validity and utility of personalised medicine with special emphasis on the prevention of chronic diseases. The book is a useful resource for policy makers, industry and healthcare professionals, scientists, technology-sector professionals, investors, citizens, and private companies that need proper advice to realise the potential of personalised medicine.

Contents:
Introductions
Identification of biomarkers for the prevention of chronic disease
Evaluation of predictive genomic applications
Ethico-legal and policy issues surrounding personalised medicine
Roles and responsibilities of stakeholders in informing healthy individuals on their genome: a sociotechnical analysis
Identification of organisational models for the provision of predictive genomic applications --

Summary: "The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combatdegenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine"--Publisher's description.

Contents:
Approaches for identifying novel targets in precision medicine: lessons from DNA repair / Dean T. Williams, Christopher J. Staples
Nucleotide excision repair: from neurodegeneration to cancer / Anastasios Liakos, Matthieu D. Lavigne, Maria Fousteri
Role of protein linked DNA breaks in cancer / Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy
The emerging role of proteomics in precision medicine: applications in neurodegenerative diseases and neurotrauma / Rana Alaaeddine, Mira Fayad, Eliana Nehme, Hisham F. Bahmad, Firas Kobeissy
The role of nitric oxide from neurological disease to cancer / Ahmed Maher, Mohamed F. Abdel Rahman, Mohamed Z. Gad
RNA nuclear export: from neurological disorders to cancer / Guillaume M. Hautbergue
Can astrocytes be a target for precision medicine? / Chloe F. Allen, Pamela J. Shaw, Laura Ferraiuolo
Mitochondrial diseases as model of neurodegeneration / Laila A. Selim, Heba Hassaan
Personalised medicine: genome maintenance lessons learned from studies in yeast as a model organism / Arwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed M. Ali, Sherif El-Khamisy [and others]
The power of zebrafish in personalised medicine / Sarah Baxendale, Freek van Eeden, Robert Wilkinson
Personalized medicine and resurrected hopes for the management of Alzheimer's disease: a modular approach based on GSK-3[beta] inhibitors / Reem K. Arafa, Nehal H. Elghazawy
Regenerative medicine: advances from developmental to degenerative diseases / Nicholas F. Blair, Thomas J. R. Frith, Ivana Barbaric
Gene therapy in the nervous system: failures and successes / Jayanth S. Chandran, Joseph M. Scarrott, Pamela J. Shaw, Mimoun Azzouz.

Summary: Brain disorders (neurodevelopmental, neurodegenerative, and affective disorders) can be investigated, treated, and prevented using person-centered methods. Because researchers have not reached a clear consensus on whether or not personality is stable or changeable, it has been difficult to outline how to use these methods in the care of people with brain disorders. Thus, the first part aims to identify the ways in which brain disorders and personality are linked. The second part explores different person-centered approaches that can be incorporated in a healthcare or education setting to help people with various brain disorders and to promote physical, mental and social health. The third part focuses on challenges and new venues.

Contents:
Part 1 Chapter 1
Personality and the Brain
Chapter 2
Personality Stability and Change in Alzheimer's Disease and Major Depressive Disorder
Chapter 3
Affect, Stress, and Neurodegenerative Onslaughts
Chapter 4
Aspects of Personality Traits and Changes in Different Stages of Dementia Disorders
Chapter 5
The Study of Personality Traits in the Blekinge part of the Swedish National Study on Aging and Care (SNAC-B)
Chapter 6
Neurodevelopmental Disorders, Temperament, and Character
Part 2 Chapter 7
Person-Centered Approaches
Chapter 8
A Case Study in Sweden: The Need of Person-Centered Methods in the Care of Dementia Patients with Severe Aggressive Behavior
Chapter 9
Life Narratives and Elderly Care
Chapter 10
Acting as a Person-Centered Approach: Theater for the Elderly
Chapter 11
Transcranial Magnetic Stimulation in the treatment of Major Depressive Disorder: a personalized approach
Chapter 12
Person-Centered Schools
Chapter 13
Integrating healthy personality development and educational practices: The case of student engagement with school
PART 3 Chapter 14
Current Directions in Psychiatric Classification: From the DSM to RDoC
Chapter 15
The Future of Person-Centered Care Services: Scientific, Measurement, and Practical Advancements in Personality and Brain Disorders.

Summary: A tremendous amount of research has been performed looking at the relationship between personality and disease. Research on this topic has been spread throughout scientific journals on psychology, behavioral health, psychoneuroimmunology, oncology, and epidemiology. Personality and Disease brings this research together in one place for the first time. With contributions from world experts, the book summarizes research findings on personality as it relates to cancer, heart disease, diabetes, asthma and allergies, dementia, and more. Is there such a thing as a cancer- prone personality? Do sadness, anger, stress, or shyness affect the likelihood that we will fall ill to specific diseases? Can we protect ourselves from disease through a positive outlook? This book will address both what we know, and what we persist in believing despite evidence to the contrary, and why such beliefs persist in the face of evidence.

Summary: This book thoroughly illustrates the designed and tailored medical approaches for tumors of the female reproductive organ. The chapters explore different cancer species such as ovarian cancer, endometrial cancer, cervical cancer, etc. Various treatment modalities such as immunotherapy and histotype-specific treatment are delivered, and it offers a chapter on how genome-wide analysis contributes to personalized treatment. It is essential to understand this concept because many molecular target drugs and the prevalence of genome-based analysis in clinical settings have enabled us to introduce valid precision medicine in the field of gynecologic oncology. Chapters explain the stream of transition from conventional standardized treatment to personalized treatment and address future perspectives. Personalization Gynecologic Oncology is a well-designed source for beginning to advanced oncologists, gynecologists, geneticists, genetic counselors, and nurses. Offering the latest treatment strategies, the Editor hopes the ideas presented here will be a foundation for further development in the field.

Contents:
1 Personalized treatment in ovarian cancer
2 Carcinogenesis and personalization in hpv-associated precancer lesions of the cervix
3 Personalized treatment for gestational trophoblastic tumor
4 Personalized treatment in uterine sarcoma
5 Clinical relevance of brca1/2 pathogenic variants and impaired dna repair pathways in ovarian carcinomas
6 Personalized treatment in immunotherapy for gynecologic cancer
7 Risk assessment and prevention strategies for hereditary gynecological cancers
8 How genome-wide analysis contributes to personalized treatment in cancers including gynecologic cancers
9 Personalized treatment of gynecological cancer according to age and symptom benefit.

Contents:
Personalized Dermatology
Genetic testing
Evolutionary Dermatology
Climate change and Skin Cancer
Ecological Dermatology
Human skin biodiversity and how it is changing
The Future of Dermatology
Combining diagnostic skills with genetic results.

Summary: "Because there is no disease condition that can be treated with the administration of anaesthetic medications, the specialty of anaesthesiology does not possess a curative effect in itself. Nevertheless, achieving the state of anaesthesia or the anaesthetic state relies completely on the use of drugs. Drugs used in anaesthesia are very powerful and able to transiently break the most deeply rooted physiological defence mechanisms. Some of the effects induced are lack of consciousness, absence of response to pain, absence of muscle tone, immobility, lack of breathing, dysfunction of the autonomous nervous system, to name just a few. Some of these effects might be considered target or "therapeutic effects", such as unconsciousness, analgesia or immobility, but others are "side effects" that are induced because of the relative low specificity of currently used anaesthetic drugs"-- Provided by publisher.

Summary: "Personalized and Precision Integrative Cardiovascular Medicine embraces a systems-oriented medical approach that works to identify and understand the underlying or root causes of disease. It takes into account the personalization of healthcare as each patient is unique. It employs in-depth health history taking, scientific testing and environmental and lifestyle review. It is used as disease prevention and for the treatment of chronic conditions (such as heart disease) through nutrition, supplementation, life-style changes, and stress management. Integrative Medicine is a model of healthcare in which conventional Western medicine is integrated with non-conventional or alternative modalities. And Metabolic Medicine/Cardiology is a newer field of medicine which concentrates on the prevention, management and treatment of cardiovascular disease at the cellular level through biochemical interventions. All three of these complementary approaches to Cardiovascular Medicine will be covered in this new title"-- Provided by publisher

Summary: This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.

Contents:
Intro; Acknowledgments; Contents; Contributors; Part I: Introduction;
Chapter 1: Birth of a Discipline: Personalized and Precision Medicine (PPM) Informatics; Introduction to PPM and Its Relationship with Informatics; Purpose of the Present Book; Purpose of Present Volume; Contents and Structure of the Book; Classical Personalized and Precision Medicine; Newer and Emerging Forms of PPM; References; Part II: Classical PPM;
Chapter 2: Clinical Risk Assessment and Prediction; Overview of Early PPM Modalities; Growth Curves; Risk Factors; Delivery of Classical PPM Tools at Point of Care Modeling Disease Severity and RiskDisease Staging; Prediction Models; Modeling Risk of Binary Events; Evaluating Prediction Models; Selection of New Risk Factors; Nomograms; Looking Forward; References;
Chapter 3: Principles of Guideline-Driven PPM Informatics; Guidelines Driving Precision Care; Computable Guidelines and Informatics Considerations; References;
Chapter 4: Genetic Counseling at the Intersection of Clinical Genetics and Informatics; Introduction; Genetic Counseling: Traditional Roles and Service Delivery Models; Genetic Testing; Genetic Testing Results; Carrier Screening Newborn ScreeningDiagnostic and Predictive Testing; Pharmacogenomics; Genetic Counseling Practice Guidelines; Genetic Counseling Educational Standards; Ethical and Legal Considerations; Autonomy, Beneficence, Non-maleficence, and Justice; The Health Insurance Portability and Accountability Act (HIPAA); The Genetic Information Nondiscrimination Act of 2008; Duty to Warn; Expanding Roles and Service Delivery Models for Genetic Counseling; Genetic Counselors in Utilization Management; Genetic Counselors in the Public Health Setting; Conclusion; References
Chapter 5: Fundamentals of Drug Metabolism and Pharmacogenomics Within a Learning Healthcare System Workflow PerspectiveIntroduction; Foundations of Pharmacogenomics for Precision Medicine Informatics; Origins of Pharmacogenetics; Modern Pharmacogenomics; Learning Healthcare System Workflow for Pharmacogenomics; Reverse Translation: Advancing Pharmacogenomics Knowledge with Real World Data; Sequencing Technologies and Data Pre-processing; Publicly Available Data Sources and Resources; Translational Informatics Study Design; Agnostic Signal Detection and Dimensionality Reduction Signal Tuning and ValidationSignal Augmentation and a Priori Knowledge; Forward Translation: Augmenting Clinical Practice with Actionable Pharmacogenomics Knowledge; "N of 1" and Comparable Populations; Signal Robustness and Sequencing Technology Considerations; Knowledge Management and Representation; Computational Tools to Navigate Signals; Appropriate Conveyance of Knowledge; Future Directions; Summary and Conclusion; References;
Chapter 6: The Growing Medication Problem: Perspective from Industry; Introduction; RightMed® Comprehensive Solution; Precision Medicine Information Challenge

Summary: The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Contents:
1. Introduction Food and Brain
2. Food and Behavior
3. Food and Psychological Wellbeing
4. Food and Cognition
5. Autism and Food
6. Healthy Brains: Types of Food and their Active Pharmacological Ingredients
5. Dieting: Importance of Diet and Diet Types
6. Nutrigenomics
7. Epigenetics
8. Gut Microbiota (microbiome)
9. Personalized Nutrition
10. Vegetables
11. Fruits
12. Nuts, Seeds and Spices
13. Grains [Oats, Barley & Quinoa]
14. Seafood [fish like Salmon, Oyster, Sea vegetables (algae)]
15. Other
16. Autism Management through Food and Diet
17. Personalized Nutrition Therapy.

Contents:
Personalized management of breast cancer / Travis L. Holloway & Ismail Jatoi
Diagnosis and biomarkers / Aysegul Sahin & Alexandra Shaye Brown
Molecular subtypes of breast cancer / Henry O. Ebili, A. Olayiwola Oluwasola & Olufunmilayo I. Olopade
Surgery and radiotherapy : patient selection and clinical outcomes / Travis Holloway & Ismail Jatoi
Hormone-blocking therapy : patient selection and clinical outcomes / Annie R. Su & Mothaffar F. Rimawi
EGF receptor inhibitors : patient selection and clinical outcomes / Sean Warsch, Gabriel Tinoco, Stefan Glück, Kiran Avancha & Alberto J. Montero
Antiangiogenic therapy : patient selection and clinical outcomes / Sheeba Irshad, Andrew Tutt & Paul Ellis
Current guidelines of breast cancer management / Cristina Falci, Zora Baretta & Silvio Monfardini
Management algorithms of breast cancer / Paolo Carli, Loredana Militello, Elena Torrisi, Alessando Tuzi & Andrea Veronesi
Index.

Summary: In dealing with the unprecedented COVID-19 pandemic, there are an increased number of patients requiring personalized management as the disease pathology varies. With variable lung compliance and airway resistance as well as the severity of the disease, one size will not fit all patients. This book is problem-oriented with evidence-based discussions of the daily encountered scenarios in the ICU for mechanically ventilated patients, dealing with the pathology, monitoring and troubleshooting facing intensivists daily. These scenarios are managed utilizing a goal-directed approach and algorithms to achieve these goals. All chapters contain an explanation of a different solution illustrating the respiratory mechanics, physiology and pathology involved in such a scenario. Each chapter also closes with a take-home message to summarize the content. In addition to describing the ventilation of different patient categories, this text also features ventilation cases specific to COVID-19 including airway management in the enhanced air born isolated patient, pulmonary embolism, different states of shock and differential lung ventilation. There is also a specific chapter on monitoring mechanical ventilation with point of care ultrasound, which is an available modality in most ICUs. Another unique chapter describes how to connect more than one patient to one ventilator in case of a shortage of machines. Written by experts in the field, Personalized Mechanical Ventilation is a timely and valuable resource for critical care physicians, nurses and respiratory therapists on the front lines of both COVID-19 and day-to-day care of mechanically ventilated patients in the ICU.

Contents:
Respiratory Physiology and mechanics at the bedside
Principals of Mechanical Ventilation
Understanding Circuit, Filters and Humidification
Airway management during Mechanical Ventilation COVID 19
Non-invasive ventilation, AVAPS and high-flow nasal Cannula
Modes of Mechanical Ventilation
Acute respiratory failure
Mechanical Ventilation in trauma patient
Mechanical ventilation in Obese patient
Postoperative Mechanical ventilation (fast track)
Guidelines to set the ventilator for (COVID-19)
Prone position during Mechanical Ventilation
Using one ventilator for multiple patients
Ventilator associated pneumonia
Mechanical ventilation during pregnancy
The Art of Weaning and Extubation
Mechanical ventilation in shock state
Respiratory monitoring Clinical and technical consideration
Role of Point of Care Ultrasound during Mechanical Ventilation
Acute respiratory distress and ARDS like syndromes
Patient-ventilator dyssynchrony
Unilateral lung disease and differential lung ventilation
Obstructive airways disease
Mechanical ventilation during ECMO (VV/VA)
Mechanical ventilation in Neurocritical care patient
Common Troubleshooting in daily practice.

Summary: This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.

Contents:
The role of personalized medicine in current and future clinical practice; the impact of cellular and molecular medicine in perioperative care.- Personalized anesthesia and genomics, transcriptomics, proteomics and metabolomics of anesthesia and pain management.- Personalized anesthesia in central and peripheral nervous system.- Personalized cardiac anesthesia.- Personalized anesthesia for lungs and respiratory tract.- Personalized medicine in pain management.- Personalized anesthesia for pediatrics and neonates.- Personalized anesthesia for musculoskeletal system.- Personalized anesthesia for renal and genitourinary system.- Personalized anesthesia for GI tract and hepatobiliary system.- Personalized critical care medicine.- Personalized anesthesia in hematologic and coagulation system.- Personalized medicine in anesthetic pharmacology.- Personalized medicine and perioperative stress response modification.

Contents:
Emerging Role of Personalized Medicine in Oral Health: Personalized Oral Health Care and the New Health Care Environment
Omics Technology: Application to Oral Disease Prevention, Disease Prediction and Diagnosis
Omics-Based Technology Development
Personalized Medicine in Dental Practice: Personalized Oral Medicine and Transformation of Dental Practice
Health Information Technology and Integrative Medicine
Comprehensive Genetic Testing in Dental Practice
Biomarkers for Individualized Oral Cancer Therapy
Metabolomics and Oral Disease Diagnosis
Companion Diagnostics in the Dental Office
Genomics of Dental Caries and Caries Risk Assessment
Genomics of Periodontal Risk Assessment and Disease Progression
Personalized Oral Medicine and Public Health: Personalized Oral Medicine and Personalized Health Insurance
The Economics of Personalized Oral Medicine
Educating Dental Students and Dental Practitioners for the Practice of Personalized Oral Medicine
Personalized Oral Health Care and the Future Oral Health Care Workforce
Personalized Oral Medicine and the Global Diagnostic Market Place
Opportunities and Challenges Shaping the Future of Personalized Oral Health Care.

Summary: This book integrates the concepts of big data analytics into mental health practice and research. Mental disorders represent a public health challenge of staggering proportions. According to the most recent Global Burden of Disease study, psychiatric disorders constitute the leading cause of years lost to disability. The high morbidity and mortality related to these conditions are proportional to the potential for overall health gains if mental disorders can be more effectively diagnosed and treated. In order to fill these gaps, analysis in science, industry, and government seeks to use big data for a variety of problems, including clinical outcomes and diagnosis in psychiatry. Multiple mental healthcare providers and research laboratories are increasingly using large data sets to fulfill their mission. Briefly, big data is characterized by high volume, high velocity, variety and veracity of information, and to be useful it must be analyzed, interpreted, and acted upon. As such, focus has to shift to new analytical tools from the field of machine learning that will be critical for anyone practicing medicine, psychiatry and behavioral sciences in the 21st century. Big data analytics is gaining traction in psychiatric research, being used to provide predictive models for both clinical practice and public health systems. As compared with traditional statistical methods that provide primarily average group-level results, big data analytics allows predictions and stratification of clinical outcomes at an individual subject level. Personalized Psychiatry – Big Data Analytics in Mental Health provides a unique opportunity to showcase innovative solutions tackling complex problems in mental health using big data and machine learning. It represents an interesting platform to work with key opinion leaders to document current achievements, introduce new concepts as well as project the future role of big data and machine learning in mental health. .

Summary: This book highlights the work of pioneers in this field, in order to inspire their peers, healthcare leaders and an interested audience. Prior to the respective care practices, the authors describe the core of personalized care and illustrate its connections to value-driven care and evidence-based medicine. The last part of the book addresses organizational and other conditions under which personalized care can thrive. In the Netherlands, substantial work is being done on value-driven care and more is currently being discussed. This book focuses on the benefits of value-driven care for patients and healthcare providers alike. To do so, it explores a range of representative cases and scenarios, such as: Scenario 1: You are able to surgically remove the most difficult tumors and find out one day that you don't need to do so in all indicated patients. Later you can find out how to recognize when surgery isn't the best treatment for certain patients. And now your team has a fixed routine to find the optimal choice together with the patient. Scenario 2: You consider yourself to be a patient-centered doctor who is really in touch with their patients--until you ask them to report for themselves on how they are doing. In the "patient-reported outcomes" you see that you have completely missed an important aspect. Later, you can structurally integrate this into your outpatient clinic. Scenario 3: In line with the planning principles of your hospital, you see chronic patients once a year--and of course also 'as needed'--until your data shows you that you see patients too early or too late, but rarely when it would be most helpful. Later you can discover how to offer your consultation exactly on time--based on early signals and often even before the patient calls the clinic. This is what value-driven care is all about: care is of more significance to the patient when it is tailored to his or her unique situation. Recognizing the patient's needs, preferences and values, and structurally adapting care accordingly--that is the noble profession of value-driven care, which takes us an important step closer to the ideal of personalized care.

Contents:
Introduction
Personalized care as value-driven care
Evidence Based Medicine and personalized care
The IBD coach for person-oriented care
Onco-geriatric MDO is based on treatment goals of older oncology patients
I repair: EHealth application in the interest of the patient, healthcare professional and the BV. The Netherlands. a school example of value-driven care!
Metabolic network for customized prevention and treatment
Personal attention for the patient in Zorgpad Pituitary tumor
Value-driven care for chronic kidney damage
From process improvement aimed at quality and safety to a change process with care providers and patients to achieve personalized care: Radboudumc Basis op Orde
Care monitor supports outcome-oriented care for patients with head and neck cancer
Cleft lip and palate
Turner
Breast Cancer in the Region with Dashboard / The State of Patient-Centered Breast Cancer Care: an Academic Center's Experience and Perspective
Pregnancy and childbirth care
Better experiences of rheumatism patients through value-driven patient journey
Organizational bed for person-centered care
Interprofessional learning and working
With regional funding towards transparent and personalized care. .

Contents:
Part I Treatment for the Patients Having Breast Cancer High-Risk
Chapter I Risk-Reducing Surgery for Breast Cancer Patients with BRCA Mutations
Chapter 2 Prophylactic Risk Reducing Surgery for Breast Cancer
Chapter 3 Merits and Demerits of Practice for Hereditary Breast and Ovarian Cancer Syndrome (Advices and Issues)
Part II Axillary Treatment
Chapter 4 Sentinel Lymph Node Biopsy and Neoadjuvant Chemotherapy in Breast Cancer Patients
Chapter 5 Axillary Reverse Mapping (ARM) as a Means to Reduce Lymphedema During Sentinel Lymph Node or Axillary Node Dissection
Chapter 6 Ultrasound for Axillary Staging
Chapter 7 One Step Nucleic Acid Amplification(OSNA)Assay for Primary Breast Cancer
Chapter 8 Management of the Clinically Node-Negative Axilla in Primary Breast Cancer
Chapter 9 Lymphatic Mapping and Optimization of Sentinel Lymph Node Dissection
Part III Radiation therapy
Chapter 10 Personalization of Radiotherapy for Breast Cancer
Chapter 11 New Technologies in Radiation Therapy
Chapter 12 Radiotherapy Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Part IV Preoperative Hormone Therapy
Chapter 13 Novel Translational Research of Neoadjuvant Endocrine Therapy
Chapter 14 Alterations of Biomarkers by Neoadjuvant Endocrine Therapy
Part V Preoperative chemotherapy
Chapter 15 Essence of Neoadjuvant Therapy
Chapter 16 The challenge to Overcome Triple Negative Breast Cancer Heterogeneity
Chapter 17 Surgical Management of Breast Cancer after Preoperative Systemic Treatment
Chapter 18 Imaging of Tumor Response by Preoperative Systemic Treatment
Part VI Preoperative anti-HER2 therapy
Chapter 19 Human Epidermal Growth Factor Receptor (HER) Family Molecular Structure
Chapter 20 Locoregional Therapy Following Neoadjuvant Therapy for HER2-Positive Breast Cancer: Opportunities and Challenges
Part VII Mathematical prediction/assessment model
Chapter 21 Nomograms to predict positive resection margin and to predict 3 or more positive lymph nodes
Chapter 22 Practical Use of Nomograms
Chapter 23 Data Mining and Mathematical Model Development.

Summary: This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

Contents:
Definition and Scientific Background of Personalized Management
Dermato-Oncology: Malignant Melanoma
A Personalized Approach to the Treatment of Basal Cell Carcinoma
From Single Actinic Keratosis to Field Cancerization
Cutaneous T Cell Lymphoma
Merkel-Cell Carcinoma and Sarcomas
Chronic Inflammatory Skin Diseases: Personalized Management of Atopic Dermatitis
Immunosuppressors or Biologicals for Distinct Forms of Psoriasis?
Autoimmune Diseases: Acknowledging the Clinical Heterogeneity of Lupus Erythematosus
Bullous Diseases
Vasculitis.

Summary: Personalized medicine is a rapidly emerging area in health care, and asthma management lends itself particularly well to this new development. This practical resource by Dr. Stanley J. Szefler helps you navigate the many asthma medication options available to your patients, as well as providing insights into those which may be introduced within the next several years.

Contents:
A population management model of asthma and allergy / Tari Haahtela, Olof Selroos
Population health management / Monica J. Federico, Katherine Johnston
Management of severe asthma in adults / Eileen Wang, Nicole Barberis, Rohit Katial
Management and prevention of severe asthma in children / Anne M. Fitzpatrick
Exhaled nitric oxide as a biomarker for asthma in children / Joseph D. Spahn, Jonathan Malka
Blood and sputum eosinophils as a biomarker for selecting and adjusting asthma medication / Claudia L. Gaefke, Tara F. Carr
Regulatory aspects of pediatric biomarkers for assessing medication response / Gilbert J. Burckart, Dionna J. Green
Discovery and validation of new biomarkers fo personalizing asthma therapy / Kian Fan Chung
Pharmacogenomics and applications to asthma management / Emily J. Pennington, Michael E. Wechsler, Victor E. Ortega
Environmental assessment and control / Perdita Permaul, Wanda Phipatanakul
Phenotype and genotype determinants of asthma treatments / Fernando Holguin
Predicting and preventing asthma exacerbations / Dr. Heather Hoch, Dr. Andrew H. Lui
School-centered asthma programs / Lisa Cicutto
Systems biology approaches to asthma management / Yasmeen Nkrumah-Elie, Nichole Reisdorph
The microbiome in asthma / Yvonne J. Huang
Preventing the development of asthma / Jeffrey R. Stokes, Leonard B. Bacharier
Identifying and preventing the progression of asthma to chronic obstructive pulmonary disease / Padmaja Subbarao, Malcolm R. Sears
Imaging procedures and bronchial thermoplasty for asthma assessment and intervention / Shweta Sood, Mario Castro
Future directions in asthma management / Stanley J. Szefler, Michael E. Wechsler.