Books

Summary: Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for over 300,000 deaths worldwide in 2017. The HIV epidemic has undermined TB control efforts in many countries across the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities. The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.

Contents:
1. Overview of the HIV-associated tuberculosis epidemic
2 . Epidemiology of Drug-susceptible, Drug-resistant Tuberculosis and HIV in Africa
3. Modelling the HIV-associated TB epidemic and the impact of interventions aimed at epidemic control
4. Immune responses to Mycobacterium tuberculosis and the impact of HIV infection
5. Clinical Manifestations of HIV-associated tuberculosis in adults
6. The tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)
7. Diagnosis of HIV-associated tuberculosis
8. Recent advances in the treatment of latent tuberculosis infection among adults living with HIV
9. Treatment of drug-sensitive tuberculosis in persons with HIV
10. Drug-resistant TB and HIV
11. Co-treatment of tuberculosis and HIV: pharmacologic considerations
12. HIV and TB in children
13. Neurological TB in HIV.

Summary: Revisiting the thinking on vulnerability to HIV and risk of infection, this book provides better understanding by considering the risk of HIV infection alongside notions of personal and collective resilience, dignity and humiliation. The work shows that young people in the urban slum dignify their world and, in doing so, establish priorities and draw on a set of references oftentimes intelligible to them alone. Moreover, humiliation, as an interpersonal event, adds to a sense of vulnerability and lies closely behind choices directly affecting personal health and livelihood. Thus, dignity and humiliation are shown for the first time to have a critical role in health seeking and risky behavior related to HIV, and this is an area in great need of further research. The crucial focus of this work is further emphasized by the rapid growth of urban slums, and high rates of HIV among both slum dwellers and young people, who continue to bear the brunt of the AIDS epidemic, thirty years on. This comprehensive literature review provides a compelling argument that the time is right to further explore the nexus of risk and resilience from a people-centered perspective. Fresh insight is critical to reach the goal of ending AIDS by 2030.

Contents:
1. Introduction
2. Vulnerability and Risk
health and well being in the slum
3. HIV as an urban epidemic
4. Young people -vulnerability, risk and HIV in the urban slum
5. Migration, young people and vulnerability in the urban slum
6. Conclusion
strengthening the evidence.

Contents:
Pathology
Epidemiology
Non-Hodgkin Lymphoma.-Hodgkin lymphoma
Acute Myeloid Leukemia (AML) & Myelodysplastic Syndrome (MDS)
Acute lymphoblastic leukemia (ALL)
Autologous stem cell transplantation
Allogeneic stem cell transplantation
Multiple myeloma and monoclonal gammopathy of unknown significance
Myeloproliferative disorders
Multicentric Castelman's disease
Chemotherapy and interactions with combination antiretroviral therapy (cART)
Special considerations.

Summary: Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.-- Source other than Library of Congress.

Contents:
HIV glycomics and glycoproteomics / Camille Bonomelli ... [et al.]
Innate recognition of HIV-1 glycans : implications for infection, transmission, and immunity / Angelic M.G. van der Aar, Sonja I. Gringhuis, and teunis B.H. Geijtenbeek
The influence of HIV enveloppe glycosylation on adaptive immune response / Catarina E. Hioe, Rajnish Kumar, and Shiu-Lok Hu
Role of HIV glycans in transmission and immune escape / Penny L. Moore, Megan K. Murphy, and Cynthia A. Derdeyn
Molecular recognition of HIV glycans by antibodies / Leopold Kong, Robyn L. Stanfield, and Ian A. Wilson
Anti-carbohydrate HIV vaccine design / Lai-Xi Wang ... [et al.]
Lectins as HIV microbicides / Leonardus M.I. Koharudin and Angela M. Gronenborn.

Summary: More people in communities of color are contracting, living with, and being treated for HIV/AIDS than ever before. In 2005, 71% of new AIDS cases were diagnosed in people of color. The rate of HIV infection in the African-American community alone has increased from 25% of total cases diagnosed in 1985 to 50% in 2005. Latinos similarly comprise a disproportionate segment of the AIDS epidemic: though they make up only 14% of the U.S. population, 20% of AIDS cases diagnosed in 2004 were Latino/a. Though the number of racial and ethnic minority HIV/AIDS cases continues to grow, the health care community has been unable to adequately meet the unique medical needs of these populations. African-American, Latino/Latina, and other patients of color are less likely to seek medical care, have sufficient access to the health care system, or receive the drugs they need for as long as they need them. HIV/AIDS in Minority Communities acknowledges the prevalence of HIV/AIDS within minority communities in the U.S. and strives to educate physicians about the barriers to treatment that exist for minority patients. By analyzing the main causes of treatment failure and promoting respect for individual and cultural values, this book effectively teaches readers to provide responsive, patient-centered care and devise preventive strategies for minority communities. Comprehensive chapters contributed by physicians with extensive experience dealing with HIV/AIDS in minority communities cover issues as far-reaching as: anti-retroviral therapy; dermatologic manifestations and co-morbidities of the disease in patients of color; unique risks to women and MSMs of color; participation of minority cases in HIV research; and substance abuse and mental health issues.

Contents:
Achieving health equity among US communities of color at risk for or living with HIV
Epidemiology of HIV infection in communities of color in the United States
PrEP and the Black community
HIV prevention, care, and treatment among Black men who have sex with men (MSM)
HIV/AIDS and the Latino populations in the United States
Women of color and HIV
HIV and immigrants from sub-Saharan Africa and the Caribbean living in the United States
HIV in the South
Neighborhood-level structural factors, HIV and communities of color
Substance use disorder and HIV
HIV prevention, care and treatment for transgender communities of color
Medical mistrust, discrimination, and the domestic HIV epidemic
Incarceration and the HIV epidemic.

Summary: This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection. .

Contents:
Foreword
Introduction and Epidemiology
Transmission and Pathogenesis
Diagnosis
Clinical Manifestation
Management
HIV and TB
Opportunistic Infections
Immunisation of HIV infected child
Special Populations, Neonates and Adolescents
Cure
HIV and the Microbiome.

Summary: This book is a practical guide in understanding how to prevent HIV transmission, to recognize risk behaviors, and to add something else to their repertoires. It aims to empower clinicians and provide a sense of security and competence with the recognition and understanding of some of the psychiatric illnesses that complicate and perpetuate the HIV pandemic that continue to persist throughout every area of the world despite the magnitude of the progress that has transformed the illness from a rapidly fatal to chronic illness that is no longer life-limiting. Missing in most of the literature on HIV is the subtle, and sometimes not so subtle, contribution of psychiatric symptoms, psychiatric illness, and risk behaviors that drive the pandemic and serve as catalysts for new infections. This practical guide provides state-of-the-art understanding of not only prevention but also a way to recognize risk behaviors, psychiatric symptoms, and psychiatric illnesses that will demystify and decode the sometimes enigmatic and frustrating reasons for nonadherence with diagnostic procedures and life-saving treatments and care. All behaviors and pathology are covered as well as the resources and treatments available. The goal of this text is to refresh knowledge on the current state of psychiatric illness management among people living with HIV, to provide a concise volume on the psychiatric aspects of HIV prevention and treatment that substantially impact the overall care of the patient, and to help understand the psychiatric catalysts of the pandemic Written by experts in the field, HIV Psychiatry: A Practical Guide for Clinicians provides enduring guidance to medical and other professionals caring for complicated clinical patients as they face ongoing challenges in working with persons with HIV and AIDS.

Contents:
The Definition and Scope of HIV Psychiatry - How to Provide Compassionate Care
HIV Testing and Prevention
HIV Stigma
Consultation, Assessment, and Evaluation
Screening for Psychiatric Disorders in HIV Care
Depressive Disorders
Trauma and Stressor-Associated Disorders
Bipolar Disorders
Anxiety Disorders
HIV-Associated Neurocognitive Disorders and Delirium
Substance-Related and Addictive Disorders
HIV and Serious Mental Illness
Suicide in HIV
HIV Syndemics
HIV in Specific Populations
Principles of HIV Treatment
Antiretrovirals and Psychotropics: Drug Interactions and Complications
Treatment of Comorbid HIV/HCV
Integrated and Collaborative Care
Palliative and End-of-Life Care in HIV
Legal and Ethical Aspects of HIV Psychiatry
The COVID-19 Outbreak and the HIV Pandemic.

Summary: "This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry"--Publisher's description.

Contents:
HIV vaccines. HIV vaccine efficacy trials: RV144 and beyond / Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan
HIV T-cell vaccines / Beatriz Mothe, Christian Brander
HIV broadly neutralizing antibodies: VRC01 and beyond / Xueling Wu
Structural features of broadly neutralizing antibodies and rational design of vaccine / Tongqing Zhou, Kai Xu
Monkey models and HIV vaccine research / Zhiwei Chen
Treatment of HIV for the prevention of transmission in discordant couples and at the population level / M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen
HIV cure. HIV persistence on antiretroviral therapy and barriers to a cure / Julia Marsh Sung, David M. Margolis
The molecular biology of HIV latency / Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell [and others]
Cellular determinants of HIV persistence on antiretroviral therapy / Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión
In vitro and in vivo models of HIV latency / James B. Whitney, R. Brad Jones
Measuring HIV persistence on antiretroviral therapy / Bethany A. Horsburgh, Sarah Palmer
Clinical interventions in HIV cure research / Thomas Aagaard Rasmussen, Ole S. Søgaard.

Summary: "Accounts of hoarding behaviors stretch back thousands of years--most recently depicted in popular reality television series--but it wasn't until the publication of DSM-5 in 2013 that hoarding was classified as a disorder in its own right rather than as a symptom of obsessive-compulsive disorder or obsessive-compulsive personality disorder. In this single source, readers can access the most up-to-date comprehensive information on what is known about the disorder. Drawing on both the authors' own clinical experience and published research, Hoarding Disorder: A Comprehensive Clinical Guide examines the phenomenology and etiology of the disorder, as well as psychotherapeutic and pharmacological treatments, challenges, and future directions. Appendixes feature useful symptom rating scales that can be applied to practice. Whether readers are practicing psychiatrists, psychologists, or other mental health professionals; professionals in training; or peer support counselors and community advocates; all will benefit from the wealth of information in this volume--made more easily accessible through key points in each chapter--and find the guidance they need to effectively and compassionately treat patients with hoarding disorder"-- Provided by publisher.

Contents:
Introduction and history
Diagnosis and comorbidity
Assessment
Insight and motivation
Cognitive-behavioral model
Neurobiology
Cognitive-behavioral therapy
Pharmacotherapy
Harm reduction
Community
Elders
Animal hoarding
Squalor
Conclusions and future directions.

Summary: This book offers in-depth information on pathological hoarding, describing both the root of the disorder and its progression. How can hoarding disorder be diagnosed? What are the challenges involved in treatment? How can professionals best deal with those affected? In this practical guide, health professionals will find the answers to these and many other questions. In the last few years the awareness of this disorder has gradually increased not only in the academic community, but also in the media and it has become clear that there are a considerable number of people worldwide who continue to suffer from it. The case studies presented here share essential insights into the diverse backgrounds and lives of affected individuals. In addition, hoarding disorder has since been classified as a new mental disorder by the WHO, which means many psychoanalysts, psychologists, psychiatrists and social workers will need to be trained accordingly. This book offers valuable guidance.

Contents:
Introduction
Basics of Hoarding disorder
Treatment Recommendations
Psychodynamic
Aspects: Self-Perspectives
Summary and Outlook
Messy-Quick-Test.

Summary: This book examines in detail the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the management appropriate in special clinical circumstances, including in the elderly, pregnant women, and those with lymphocyte-predominant disease. Careful attention is devoted to the emerging individually tailored treatment strategies that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The second edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by the key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma. .

Contents:
Part I: From Hodgkin's disease to Hodgkin Lymphoma: Epidemiology
The role of viruses in the genesis of Hodgkin Lymphoma
Pathology and molecular pathology of Hodgkin Lymphoma
Microenvironment, cross-talk and immune escape mechanisms
What will we learn from Genomics and Proteomics in Hodgkin Lymphoma? Part II: Diagnosis and treatment: Clinical evaluation
Functional imaging
Prognostic factors
Principles of radiation techniques in Hodgkin Lymphoma
Principles of chemotherapy in Hodgkin Lymphoma
Treatment of early favorable Hodgkin Lymphoma
Treatment of early unfavorable Hodgkin Lymphoma
Treatment of advanced-stage Hodgkin Lymphoma
Relapsed and refractory Hodgkin Lymphoma
Paediatric Hodgkin Lymphoma. Part III: Special Clinical Situations: Lymphocyte-predominant Hodgkin Lymphoma
The management of Hodgkin Lymphoma during pregnancy
The management of HIV-Hodgkin Lymphoma
The management of elderly patients with Hodgkin Lymphoma
Allogeneic transplantation for relapsed of Hodgkin Lymphoma
Targeting CD 30
Other new agents for patients with Hodgkin Lymphoma. Part IV: Survivorship: Quality of Life in Hodgkin Lymphoma
Second malignancy risk after treatment of Hodgkin Lymphoma
Cardiovascular and pulmonary late effects
Gonadal dysfunction and fertility preservation in Hodgkin Lymphoma patients. .

Summary: This book, now in its third edition, examines the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the appropriate management in special clinical circumstances, including in the elderly, pregnant women, and those with nodular lymphocyte-predominant disease (NLPHL). Careful attention is devoted to the emerging individually tailored treatment strategies, including checkpoint inhibition, that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The new edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.

Contents:
Intro
Preface
Contents
Part I: Epidemiology and Pathogenesis
1: Epidemiology of Hodgkin Lymphoma
1.1 Introduction
1.2 Definition and Histological Classification (WHO)
1.3 Hodgkin Lymphoma Occurrence
1.3.1 Overall Incidence
1.3.2 Age-Specific Incidence Patterns Vary Geographically
1.3.2.1 Historical Patterns
1.3.2.2 Modern Age-Specific Incidence Patterns
1.3.2.3 Age-Specific Incidence Patterns for Hodgkin Lymphoma Subtypes
1.3.3 Incidence Trends
1.3.4 Classifications for Epidemiological Studies: Multi-disease Models 1.3.5 Classifications by Age at Diagnosis, Histology and Tumour Epstein-Barr Virus Status
1.3.6 Overlap Between Epidemiological Classifications of Hodgkin Lymphoma
1.4 Familial Accumulation of Hodgkin Lymphoma: Genetic Predisposition
1.4.1 Genetic Studies: Genome-Wide Association Studies
1.4.1.1 Hodgkin Lymphoma Subtype-Specific Associations in Genetic Analyses
1.5 Risk Factors
1.5.1 Prevailing Hypotheses in Hodgkin Lymphoma Epidemiology
1.5.1.1 Childhood Socio- Economic Environment
1.5.2 Anthropometry
1.5.3 Medical History
1.5.3.1 Infections Epstein-Barr Virus Infection: Infectious Mononucleosis
Epstein-Barr Virus Infection: Serological Evidence
Epstein-Barr Virus Infection: Variation in Tumour Prevalence
A Four-Disease Model for Hodgkin Lymphoma
Other Childhood Infections
1.5.3.2 Primary and Secondary Immune Deficiencies
1.5.3.3 Autoimmune and Allergic Disorders
Autoimmune and Allergic/Atopic Diseases
1.5.3.4 Medications
1.5.4 Environmental Exposures
1.5.4.1 Ultraviolet Light
1.5.4.2 Tobacco
1.5.4.3 Alcohol
1.6 Conclusion
References 2: The Role of Viruses in the Genesis of Hodgkin Lymphoma
2.1 Introduction
2.2 Hodgkin Lymphoma and Epstein-Barr Virus
2.2.1 Epstein-Barr Virus and the Pathogenesis of Hodgkin Lymphoma
2.2.2 Risk Factors for Epstein-Barr Virus-Associated Hodgkin Lymphoma
2.2.3 Epstein-Barr Virus and Hodgkin Lymphoma: A Causative Association?
2.2.4 Epstein-Barr Virus and the Clinicopathological Features of Hodgkin Lymphoma
2.3 Epstein-Barr Virus-Negative Hodgkin Lymphoma Cases
2.3.1 Hodgkin Lymphoma and Herpesviruses Other Than Epstein-Barr Virus 2.3.2 Polyomaviruses and Hodgkin Lymphoma
2.3.3 Measles Virus and Hodgkin Lymphoma
2.3.4 The Virome, Anelloviruses, and Hodgkin Lymphoma
2.4 Conclusions
References
3: Pathology and Molecular Pathology of Hodgkin Lymphoma
3.1 Subclassification and Pathology
3.1.1 Nodular Lymphocyte-Predominant Hodgkin Lymphoma
3.1.2 Classical Hodgkin Lymphoma: The HRS Cells
3.1.2.1 Nodular Sclerosis Classical Hodgkin Lymphoma
3.1.2.2 Mixed Cellularity Classical Hodgkin Lymphoma
3.1.2.3 Lymphocyte-Depleted Classical Hodgkin Lymphoma
3.1.2.4 Lymphocyte-Rich Classical Hodgkin Lymphoma

Contents:
Haemopoiesis
Erythropoiesis and general aspects of anaemia
Hypochromic anaemias
Iron overload
Megaloblastic anaemias and other macrocytic anaemias
Haemolytic anaemias
Genetic disorders of haemoglobin
The white cells 1: granulocytes, monocytes and their benign disorders
The white cells 2: lymphocytes and their benign disorders
The spleen
The aetiology and genetics of haematological malignancies
Management of haematological malignancy
Acute myeloid leukaemia
Chronic myeloid leukaemia
Myeloproliferative disease
Myelodysplasia
Acute lymphoblastic leukaemia
The chronic lymphoid leukaemias
Hodgkin lymphoma
Non-Hodgkin lymphoma
Multiple myeloma and related disorders
Aplastic anaemia and bone marrow failure
Stem cell transplantation
Platelets, blood coagulation and haemostasis
Bleeding disorders caused by vascular and platelet abnormalities
Coagulation disorders
Thrombosis 1: pathogenesis and diagnosis
Thombosis 2: treatment
Haematological changes in systemic disease
Blood transfusion
Pregnancy and neonatal haematology
Appendix. World Health Organization classification of tumours of the haematopoietic and lymphoid tissues.

Summary: "Essential Haematology is established as the most authoritative introduction to haematology. Beautifully presented, it introduces the formation and function of blood cells and diseases that arise from dysfunction and disruption of these processes. Basic science, diagnostic tests, clinical features and management are all clearly explained. The book outlines the basic principles of clinical and laboratory haematology and shows how manifestations of blood diseases can be explained by new knowledge of the disease processes"-- Provided by publisher.

Contents:
Haemopoiesis
Erythropoiesis and general aspects of anaemia
Hypochromic anaemias
Iron overload
Megaloblastic anaemias and other macrocytic anaemias
Haemolytic anaemias
Genetic disorders of haemoglobin
The white cells, part 1: granulocytes, monocytes and their benign disorders
The white cells, part 2: lymphocytes and their benign disorders
The spleen
The aetiology and genetics of haematological neoplasia
Management of haematological malignancy
Acute myeloid leukaemia
Chronic myeloid leukaemia
Myeloproliferative neoplasms
Myelodysplastic syndromes
Acute lymphoblastic leukaemia
The chronic lymphocytic leukaemias
Hodgkin lymphoma
Non-hodgkin lymphomas
Multiple myeloma and related plasma cell neoplasms
Aplastic anaemia and bone marrow failure
Haemopoietic stem cell transplantation
Platelets, blood coagulation and haemostasis
Bleeding disorders caused by vascular and platelet abnormalities
Coagulation disorders
Thrombosis 1: pathogenesis and diagnosis
Thrombosis 2: treatment
Haematological changes in systemic diseases
Blood transfusion
Pregnancy and neonatal haematology.

Contents:
Section I: General. Physiology of the newborn
Nutritional support for the pediatric patient
Anesthetic considerations for pediatric surgical conditions
Renal impairment and renovascular hypertension
Coagulopathies and sickle cell disease
Extracorporeal membrane oxygenation
Mechanical ventilation in pediatric surgical disease
Vascular access
Surgical infectious disease
Fetal therapy
Section II: Trauma. Ingestion of foreign bodies
Bites
Burns
Early assessment and management of trauma
Thoracic trauma
Abdominal and renal trauma
Head injury and facial trauma
Pediatric orthopedic trauma
Neurosurgical conditions
Section III: Thoracic. Chest wall deformities
Management of laryngotracheal obstruction in children
Congenital bronchopulmonary malformations
Acquired lesions of the lung and pleura
Congenital diaphragmatic hernia and eventration
Mediastinal tumors
The esophagus
Esophageal atresia and tracheoesophageal fistula malformations
Section IV: Abdomen. Gastroesophageal reflux
Lesions of the stomach
Duodenal and intestinal atresia and stenosis
Malrotation
Meconium disease
Necrotizing enterocolitis
Hirschsprung disease
Anorectal atresia and cloacal malformations
Fecal incontinence and constipation
Acquired anorectal disorders
Intussusception
Alimentary tract duplications
Meckel diverticulum
Inflammatory bowel disease
Appendicitis
Biliary atresia
Choledochal cyst and gallbladder disease
Solid organ transplantation in children
Lesions of the pancreas
Splenic conditions
Congenital abdominal wall defects – gastroschisis and omphalocele
Umbilical and other abdominal wall hernias
Section V: Inguinal region and scrotum. Inguinal hernia
Undescended testes and testicular tumors
The acute scrotum
Section VI: Urology. Developmental and positional anomalies of the kidneys
Ureteral obstruction and malformations
Urinary tract infections and vesicoureteral reflux
Bladder and urethra
Posterior urethral valves
Bladder and cloacal exstrophy
Hypospadias
Circumcision
Prune belly syndrome
Differences of sexual development
Section VII: Neoplasms. Principles of adjuvant therapy in childhood cancer
Renal tumors
Neuroblastoma
Lesions of the liver
Teratomas, dermoids, and other soft tissue tumors
Lymphomas
Rhabdomyosarcoma
Section VIII: Skin and soft tissue diseases. Nevus and melanoma
Vascular anomalies
Head and neck sinuses and masses
Section IX: Special topics. Pediatric and adolescent gynecology
Breast diseases
Endocrine disorders and tumors
Bariatric surgical procedures in adolescence

Summary: Holistic nursing has as its goal healing the whole person, an approach that is grounded in the inherent interconnectedness of self, others, nature, and spirituality. The holistic nurse is an instrument of healing and a facilitator in the healing process, honoring the individual's subjective experience of health, health beliefs, and values, viewing the whole person and his/her needs in their entirety, with integration as the goal. This publication is a guide to the essentials of a distinctive practice specialty. -- Publisher description.

Contents:
Introduction :
Function of the scope of practice statement of holistic nursing
Function of the standard of holistic nursing
Function of competencies accompanying standards of holistic nursing
Development of the holistic nursing standards of practice: basic and advanced
Summary. Holistic nursing scope of practice :
Definition and overview of holistic nursing
Evolution of holistic nursing
Current state and trends of holistic nursing
Philosophical principles of holistic nursing
Integrating the art and science of nursing
Settings for holistic nursing practice
Educational preparation for holistic nursing practice
Certification in holistic nursing
Commitment to the nursing profession
Care of older adults in holistic nursing
Issues in holistic nursing
Education
Research
Clinical practice
Policy. Standards of holistic nursing practice :
Overarching philosophical principles of holistic nursing
Standards of practice for holistic nursing
Standards of professional performance Glossary
References and bibliography
Appendix A: Holistic nursing: scope and standards of practice, second edition (2013)
Appendix B: American Holistic Nurses Association (AHNA) position statement on holistic nursing ethics
Appendix C: Position on the role of nurses in the practice of complementary and integrative health approaches (CIHA) June 2016
Index.

Summary: This book presents a patient centric, holistic view and management strategy for registered nurses, advanced practice nurses and midwives to care for the pregnant female, including considerations in pregnancy planning. There is a significant gap in information about holistic care and nursing considerations of the pregnant female with regards to pain management, which this book fills. It develops on the preparation before pregnancy, as nutrition or exercise, on behavioural management of pain with the impact of anxiety and different therapies. The book examines the musculoskeletal pain, the headache and fibromyalgia occurring during pregnancy. It also informs on the nutraceuticals in pregnancy, the use of opioids and of nerve blocks. This book finally explores complementary treatments during pregnancy. Case-studies are presented for improved understanding and to provide a real-world perspective. This book, written by nursing and psychology experts in their fields of specialty practice, will appeal to nurses and midwives working with pregnant women or planning to have a baby.

Contents:
Chapter 1. Introduction
Chapter 2. Background
Chapter 3. In preparation for pregnancy
Chapter 4. Musculoskeletal Pain during pregnancy
Chapter 5. Headache/migraine during pregnancy
Chapter 6. Fibromyalgia/generalized body pain during pregnancy
Chapter 7. Nutraceuticals in pregnancy
Chapter 8. Opioids in pregnancy (outside OUD)
Chapter 9. Use of nerve blocks in pregnancy
Chapter 10. Complementary treatments in pregnancy
Chapter 11. Behavioural management in pregnancy
Chapter 12. Additional Case-studies.

Summary: "The original reference resource for medical oncologists, radiation oncologists, internists, and allied specialties involved in the treatment of cancer patients, Holland-Frei Cancer Medicine covers the ever-expanding field of current cancer science and clinical oncology practice. In this new ninth edition an outstanding editorial team from world-renowned medical centers continue to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging, and therapy. Holland-Frei Cancer Medicine, Ninth Edition, brings scientific principles to clinical practice and is a testament to the ethos that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. This ninth edition features hundreds of full color illustrations, photographs, tables, graphs and algorithms that enhance understanding of complex topics and make this text an invaluable clinical tool. Over 15 brand new chapters covering the latest advances, including chapters on Cancer Metabolism, Bioinformatics, Biomarker Based Clinical Trial Design, Health Services Research and Survivorship bring this comprehensive resource up-to-date. Each chapter contains overview boxes, select references and other pedagogic features, designed to make the content easy to access and absorb"--Provided by publisher.

Summary: This book provides essential information on Mexico's Holocene and Anthropocene climate and vegetation history. Considering the geography of Mexico - which is home to a variety of climatic and environmental conditions, from desert and tropical to high mountain climates - this book focuses on its postglacial paleoecology and paleoclimatology. Further, it analyses human intervention since the middle Holocene as a major agent of environmental change. Offering a valuable tool for understanding past climate change and its relationship with present climate change, the book is a must-read for botanists, ecologists, palaeontologists and graduate students in related fields.

Contents:
1) Introduction: The Holocene and Anthropocene Environmental History, of Mexico
2) Paleoclimate of the Gulf of California (Northwestern Mexico) during the last 2000 years
3) Holocene hydroclimate of the subtropical Mexico: a state of the art
4)The Environment of Ancient Cloud Forests in the Mexican Pacific
5) Sea level change and its influence on the coastal landscape in the Gulf of Mexico during the Holocene
6) Insights into the Holocene environmental history of the highlands in central Mexico
7) Integration of landscape approaches for the spatial reconstruction of the vegetation
8) Volcanic Activity in Mexico during the Holocene
9) Human Influence vs Natural Climate Variability
10) Holocene Paleoecology and Paleoclimatology of south and south-eastern Mexico: a palynological approach
11) From Calakmul to the Sea: The Historical Ecology of a Classic Maya City that Controlled the Candelaria/Champoton Watersheds
12) Lidar at El Pilar: Understanding Vegetation Above and Discovering the Ground Features Below in the Maya Forest.

Summary: Holoscopy is a new tomographic imaging modality that combines techniques of digital holography with Fourier-domain optical coherence tomography (FD-OCT). Dierck Hillmann gives a theoretical introduction to the mathematics and physics of holoscopy and develops an efficient numerical reconstruction procedure. Compared to FD-OCT, holoscopy provides unique advantages by enabling tomographic imaging without a limited depth of focus, but results in an increased numerical cost for reconstruction. In further chapters, the author introduces techniques for FD-OCT that are relevant to holoscopy as well. He demonstrates and compares numerical reconstruction methods for FD-OCT and shows how motion and dispersion artifacts in FD-OCT can be numerically compensated. Contents Theoretical Introduction to Optical Coherence Tomography and Digital Holography FD-OCT Signal Processing Using the Non-Equispaced Fast Fourier Transform Motion and Dispersion Correction in FD-OCT Holoscopy Target Groups Academics and practitioners in the fields of computer science, optical coherence tomography, digital holography, and medical imaging. The Author Dierck Hillmann received his doctoral degree in the group of Gereon Hüttmann at the Institute of Biomedical Optics in Lübeck and is currently working for a leading company in the fields of science and photonics. The Editor The series Aktuelle Forschung Medizintechnik is edited by Thorsten M. Buzug.

Contents:
Introduction
Theory
FD-OCT signal processing using the non-equispaced fast Fourier transform
Motion and dispersion correction in FD-OCT
Holoscopy
Conclusion.

Summary: This book aims to equip individual clinicians with the interdisciplinary knowledge, skills, and perspective they need to provide the best care possible. Written by experts in home-based medical care, this book consists of 20 of the most common scenarios that challenge physicians administering home-based care for geriatric patients. Each scenario requires an approach or leverages aspects of care delivery that most are not trained in. Additionally, each scenario reflects an approach to care that is enhanced by interdisciplinary input. Finally, each case lends itself to a practical problem-solving approach that could be accomplished by most home-based medical care providers, even in the absence of an interdisciplinary team. Home-Based Medical Care for Older Adults is a valuable resource for all clinicians who may administer medical care in a non-medical setting, including geriatricians, family medicine physicians, psychiatrists, home nurses, social workers, students, and other interdisciplinary team members.

Contents:
1. Involuntary Weight Loss
2. Assessing Decision-Making Capacity
3. Acute Illness at Home
4. Dementia Behavior Management
5. Bacteriuria in a Patient with Incident Delirium
6. Caregiver Burden
7. Elder Abuse and Neglect
8. Management of Frequent Falls
9. Home Assessments: Improving Patients' Capacity for Self-Management
10. Transitioning to Long-Term Care
11. Pressure Injuries
12. Opioid Management
13. Social Isolation
14. Serious Mental Illness
15. Functional Rehabilitation and Realistic Goals
16. Polypharmacy
17. Telephone Medicine
18. Morbid Obesity
19. Urinary Catheter Management at Home
20. End of Life Care.

Summary: Hypertension remains a leading cause of disability and death worldwide. Self-monitoring of blood pressure by patients at home is currently recommended as a valuable tool for the diagnosis and management of hypertension. Unfortunately, in clinical practice, home blood pressure monitoring is often inadequately implemented, mostly due to the use of inaccurate devices and inappropriate methodologies. Thus, the potential of the method to improve the management of hypertension and cardiovascular disease prevention has not yet been exhausted. This volume presents the available evidence on home blood pressure monitoring, discusses its strengths and limitations, and presents strategies for its optimal implementation in clinical practice. Written by distinguished international experts, it offers a complete source of information and guide for practitioners and researchers dealing with the management of hypertension.

Contents:
1. Devices for home BP monitoring
2. Cuff design for home BP monitors
3. Home BP and preclinical organ damage
4. Prognostic studies of home BP
5. Diagnostic value of home BP
6. Home BP monitoring schedule
7. Home BP for treatment titration
8. Home BP monitoring, treatment adherence and hypertension control
9. Home BP monitoring: Cost-effectiveness patients' preference and barriers for use
10. Home BP monitoring in clinical research
11. Home BP tele-monitoring and mobile digital health technology
12. Nocturnal home BP monitoring
13. Home BP monitoring in children, pregnancy, renal disease
14. Home BP variability
15. Home versus ambulatory BP monitoring
16. Guidelines for home BP monitoring.

Summary: Tina M. Marrelli's new book, Home Care Nursing: Surviving in an Ever-Changing Care Environment is a practical and comprehensive guidebook written concisely and without jargon or insider acronyms, making the book accessible to anyone whose work is connected to home care nursing services. Designed to provide chapters as stand-alone resources for readers with previous experience seeking updated guidance, Home Care Nursing is also an excellent guide for course or orientation material. Each chapter is packed with practical questions, discussion topics, and additional resources, such as a complete Medicare Benefit Policy for reference. Additionally, offering more than just an overview of the healthcare and home care markets, this book discusses the unique practice setting and environment of home care nursing, the laws regulations, and quality, and how to make the leap into the field, document your home visit, and improve your professional growth and development. -- Provided by publisher.

Contents:
Foreword
Introduction
Chapter 1. Healthcare: Overview of Change and Complexity
Chapter 2. What Is Home Healthcare and Home Care Comprised of Exactly?
Chapter 3. What Makes Home Care the Most Unique Practice Setting?
Chapter 4. Becoming a Home Care Clinician or Manager: Information Needed for Success
Chapter 5. The Environment of Care: The Home and Community Interface
Chapter 6. The Fundamentals: The Interface of Law, Regulation, and Quality. Chapter 7. The Home Visit: The Important Unit of Care
Chapter 8. Documentation of Care and Related Processes
Chapter 9. Where to From Here? Or Welcome to the Most Exciting Healthcare Setting There Is!
Appendix A. Home Care and Hospice/Palliative Care Organizations/Associations
Appendix B. Resources for Clinicians and Patient/Caregiver Education
Appendix C. Home Health & Hospice MAC Areas
Appendix D. Medicare Benefit Policy Manual: Chapter 7-Home Health Services.

Summary: "A road map for dismantling the fear and shame that keep you from living a free and authentic life. In the aftermath of stress, disappointment, and trauma, people often fall into survival mode, even while a part of them longs for more. Juggling multiple demands and responsibilities keeps them busy, but not healed. As a survivor of sexual assault, racism, and evacuation from a civil war in Liberia, Dr. Thema Bryant knows intimately the work involved in healing. Having made the journey herself, in addition to guiding others as a clinical psychologist and ordained minister, Dr. Thema shows you how to reconnect with your authentic self and reclaim your time, your voice, your life. Signs of disconnection from self can take many forms, including people-pleasing, depression, anxiety, and resentment. Healing starts with recognizing and expressing emotions in an honest way and reconnecting with the neglected parts of yourself, but it can't be done in a vacuum. Dr. Thema gives you the tools to meaningfully connect with your larger community, even if you face racism and sexism, heartbreak, grief, and trauma. Rather than shrinking in the face of life's difficulties, you will discover in Homecoming the therapeutic approaches and spiritual practices to live a more expansive life characterized by empowerment, healthier relationships, gratitude, and a deeper sense of purpose."-- Jacket.

Contents:
Introduction: Homesick and disconnected
part 1. Longing for home: Ring the alarm : I need a homecoming ; Internal signs of disconnection ; External signs of disconnection
part 2. Packing light : what to carry on the journey home: Reparenting yourself ; Emotional intelligence ; Community care and self-care ; Building self-confidence ; Spiritual practices
part 3. Recovering from roadblocks on the journey home: Mourning invisible losses ; Healing from breakups and divorce ; Coping and healing from a toxic workplace ; Recovering from childhood trauma ; Resisting oppression
Conclusion: Welcome home : the journey continues.

Summary: "Two half sisters, Effia and Esi, unknown to each other, are born into two different tribal villages in 18th century Ghana. Effia will be married off to an English colonial, and will live in comfort in the sprawling, palatial rooms of Cape Coast Castle, raising half-caste children who will be sent abroad to be educated in England before returning to the Gold Coast to serve as administrators of the Empire. Her sister, Esi, will be imprisoned beneath Effia in the Castle's women's dungeon, and then shipped off on a boat bound for America, where she will be sold into slavery. Stretching from the tribal wars of Ghana to slavery and Civil War in America, from the coal mines in the north to the Great Migration to the streets of 20th century Harlem, Yaa Gyasi's has written a modern masterpiece, a novel that moves through histories and geographies and--with outstanding economy and force--captures the troubled spirit of our own nation"-- Provided by publisher.

Summary: While homeless young people (HYP) are typically perceived as irresponsible and morally suspect individuals who lack essential social skills to navigate their lives, this book offers an alternative and more positive perspective. It demonstrates that HYP improvise with resources available on the streets to improve their social and financial status, although they experience significant social structural constraints. This ground-breaking text provides an analysis of social processes that contribute to young people's homelessness, their engagement in sex work, their establishment of intimate partnerships, and sexual practices which may increase their risk of HIV and other sexually transmitted infections (STIs). The book demonstrates how the ongoing social and financial instability and insecurity neutralises HYP's knowledge of HIV/STIs, and how financial considerations, fear of violence by clients, and social obligations in intimate partnerships contribute to their sexual risk-taking. The author argues that the conventional approach of promoting health through raising awareness regarding HIV/STI prevention may continue to bring less than promising outcomes unless we focus on how structural and contextual conditions operate in the backdrop and produce conditions less conducive for young people. Included in the coverage: factors that contribute to youth homelessness factors that shape sexual practice a Bourdieusian analysis of youth homelessness and sexual risk-taking a health promotion approach that can potentially reduce youth homelessness and their risk of HIV/STIs Homeless Youth of Pakistan: Survival Sex and HIV Risk will attract undergraduate and postgraduate students, and researchers interested in exploring issues such as youth homelessness, sexual risk-taking, and HIV/STIs.

Contents:
Chapter 1. Introduction
Chapter 2. Understanding Youth Homelessness
Chapter 3. Understanding Sexual Behaviour
Chapter 4. The Theory of Capital and Social Practice
Chapter 5. Methodological Approach to the Study
Chapter 6. Capital-deficit and Youth Homelessness
Chapter 7. The Street-field: A Capital-building Site
Chapter 8. Sexual Risk-taking: Competing Priorities of Capital-building, Physical Safety, and Sexual Health
Chapter 9. Key Messages and Implications for Health Promotion.

Contents:
Part I: The Facts of the Matter
Introduction
Definition and Main Principles of Homeopathy
Myths about Homeopathy
Current Popularity, Acceptance, and Regulation of Homeopathy
History of Homeopathy
Different Types of Homeopathy and Homeopaths
The Patients of Homeopaths
Homeopathy as a Criticism of Conventional Medicine
Scientific Evidence
Spurious Arguments for and Counter-Arguments against Homeopathy
Part II: Lexicon of Homeopathy.

Summary: Homeopathy is over 200 years old and is still experiencing an uninterrupted influx of new practitioners and patients. Many patients and therapists swear by this "alternative healing method", which in some countries is even financed by health insurances. This seems completely incomprehensible to critics: For them it is clearly evident that homeopathy is hopelessly unscientific and has at best a placebo effect. The positions of supporters and opponents seem to be just as immutable as they are incompatible. This book answers some essential and fascinating questions: What remains of the founding ideas of homeopathy in 21st century medicine? Does it really work and, if so, how? Which of the original theories can we still apply today with a clear conscience and use for the benefit of patients and the healthcare system? Where does homeopathy have its limits and does it indeed need to be critically reconsidered and evaluated? The author has dealt with the points of criticism for years, but at the same time also takes seriously the wishes and concerns of patients who often feel insufficiently cared for by conventional medical practice. Against the background of her own personal history, her book attempts to bridge the gap between these two traditionally opposing camps.

Contents:
Preface to the English Edition
How and on what basis does homeopathy treat?
Homeopathy- What are we talking about?
Is homeopathy part of today's medicine?
Why do patients turn to homeopathy?
What remains of homeopathy in the 21st century?
Here and Now.

Summary: Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.

Contents:
Preface.- Homeostasis
Cell cultures
Loss of homeostasis
Tumor development
Metastasis
References
Abbreviations.

Summary: 'Homeostatic Control of Brain Function' offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders.

Contents:
Homing endonucleases : from genetic anomalies to programmable genomic clippers / Marlene Belfort and Richard P. Bonocora
Bioinformatic identification of homing endonucleases and their target sites / Eyal Privman
PCR-based bioprospecting for homing endonucleases in fungal mitochondrial rRNA genes / Mohamed Hafez [and four others.]
Mapping homing endonuclease cleavage sites using in vitro generated protein / Richard P. Bonocora and Marlene Belfort
Mapping free-standing homing endonuclease promoters using 5'RLM-RACE / Ewan A. Gibb
PCR analysis of chloroplast double-strand break (DSB) repair products induced by I-CreII in chlamydomonas and arabidopsis / Taegun Kwon [and three others ]
A two-plasmid bacterial selection system for characterization and engineering of homing endonucleases / Ning Sun and Huimin Zhao
Rapid screening of endonuclease target site preference using a modified bacterial two-plasmid selection / Jason M. Wolfs, Benjamin P. Kleinstiver, and David R. Edgell
A yeast-based recombination assay for homing endonuclease activity / Jean-Charles Epinat
Rapid determination of homing endonuclease DNA binding specificity profile / Lei Zhao and Barry L. Stoddard
Quantifying the information content of homing endonuclease target sites by single base pair profiling / Joshua I. Friedman, Hui Li, and Raymond J. Monnat, Jr.
Homing endonuclease target site specificity defined by sequential enrichment and next-generation sequencing of highly complex target site libraries/ Hui Li and Raymond J. Monnat Jr.
Homing endonuclease target determination Using SELEX adapted for yeast surface display / Kyle Jacoby and Andrew M. Scharenberg
Engineering and flow-cytometric analysis of chimeric LAGLIDADG homing endonucleases from homologous I-OnuI-family enzymes / Sarah K. Baxter, Andrew M. Scharenberg, and Abigail R. Lambert
Bioinformatics identification of coevolving residues / Russell J. Dickson and Gregory B. Gloor
Identification and analysis of genomic homing endonuclease target sites / Stefan Pellenz and Raymond J. Monnat Jr.
Redesigning the specificity of protein-DNA interactions with Rosetta / Summer Thyme and David Baker.

Summary: This book provides a concise and up-to-date overview on homonymous visual field defects, with the focus especially on homonymous hemianopia. All aspects of the subject are covered, from anatomy and pathophysiology to diagnosis and management. Emphasis is placed on practical issues and major advances in ophthalmology, neurology, imaging techniques, and psychology. Rehabilitation strategies are described, and methods supporting compensation strategies are recommended. A separate chapter considers driving with homonymous hemianopia, which represents one of the critical issues in traffic ophthalmology. Homonymous Visual Field Defects will be of particular value to ophthalmologists, neurologists, neurosurgeons, and neuroscientists. It will be an invaluable asset in diagnostic and treatment decision making in patients with such defects, which occur primarily as a result of stroke, trauma, or tumor, cause reading and orientation disorders, and are the most frequent type of visual field deficit after acquired unilateral postchiasmal brain damage.--Page 4 cover.

Contents:
Anatomy of the human visual pathway
Pathophysiology
3. Perimetry and types of homonymous hemianopsia / topographic localization / clinical anatomical correlations
Neuro-ophthalmological examination in homonymous hemianopsia / clinical symptoms and functional abilities
Novel imaging techniques and neuroradiologic imaging
Pupillary disorders
Visual search disorders and ocular motility
Driving with homonymous hemianopsia
Neuropsychological / neurological testing in homonymous hemianopsia / central visual
Rehabilitation strategies
Compensational strategies of patients wth homonymous hemianopsia.

Summary: "A collection of essays taking aim at the legitimacy of the modern feminist movement, arguing that it has chronically failed to address the needs of all but a few women"-- Provided by publisher. "Today's feminist movement has a glaring blind spot, and paradoxically, it is women. Mainstream feminists rarely talk about meeting basic needs as a feminist issue, argues Mikki Kendall, but food insecurity, access to quality education, safe neighborhoods, a living wage, and medical care are all feminist issues. All too often, however, the focus is not on basic survival for the many, but on increasing privilege for the few. That feminists refuse to prioritize these issues has only exacerbated the age-old problem of both internecine discord, and women who rebuff at carrying the title. Moreover, prominent white feminists broadly suffer from their own myopia with regard to how things like race, class, sexual orientation, and ability intersect with gender. How can we stand in solidarity as a movement, Kendall asks, when there is the distinct likelihood that some women are oppressing others? In her searing collection of essays, Mikki Kendall takes aim at the legitimacy of the modern feminist movement arguing that it has chronically failed to address the needs of all but a few women. Drawing on her own experiences with hunger, violence, and hypersexualization, along with incisive commentary on politics, pop culture, the stigma of mental health, and more, Hood Feminism delivers an irrefutable indictment of a movement in flux. An unforgettable debut, Kendall has written a ferocious clarion call to all would-be feminists to live out the true mandate of the movement in thought and in deed." -- Publisher's description

Contents:
Solidarity is still for white women
Gun violence
Hunger
Of #FastTailedGirls and freedom
It's raining patriarchy
How to write about black women
Pretty for a ...
Black girls don't have eating disorders
The fetishization of fierce
The hood doesn't hate smart people
Missing and murdered
Fear and feminism
Race, poverty, and politics
Education
Housing
Reproductive justice, eugenics, and maternal mortality
Parenting while marginalized
Allies, anger, and accomplices.

Summary: The book focuses on the evolutionary impact of horizontal gene transfer processes on pathogenicity, environmental adaptation and biological speciation. Newly acquired genetic material has been considered as a driving force in evolution for prokaryotic genomes for many years, with recent technical developments advancing this field further. However, the extent and implications of gene transfer between prokaryotes and eukaryotes still raise controversies. This multi-authored volume introduces various means by which DNA can be exchanged, covers gene transfer between prokaryotes and their viruses as well as between bacteria and eukaryotes, such as fungi, plants and animals, and addresses the role of horizontal gene transfer in human diseases. Aspects discussed also include the relevance for virulence and drug resistance development on one hand, and for the occurrence of naturally derived antibiotics and other secondary metabolites on the other hand. This book offers new insights to anyone interested in genome evolution and the exchange of DNA between the different domains of life, the genetic toolkit for adaptation and the emergence of multidrug resistant bacteria.

Contents:
Intro; Contents; Part I: Horizontal Gene Transfer Among Bacteria and Bacteriophages; Horizontal Gene Transfer in Bacteria, an Overview of the Mechanisms Involved; 1 Introduction; 2 Transformation; 2.1 Transformation in Gram-Positive Bacteria; 2.1.1 Development of Competence; 2.1.2 DNA Fixation to the Recipient Cell Surface and DNA Uptake; 2.1.3 Eclipse; 2.1.4 ssDNA Integration into the Recipient dsDNA; 2.2 Transformation in Gram-Negative Bacteria; 2.2.1 Development of Competence; 2.2.2 DNA Fixation to the Recipient Cell Surface and DNA Uptake; 2.2.3 Eclipse 2 HGT in Free-Living, Antibiotic-Producing Streptomyces and Salinispora3 HGT in the Pathogens Mycobacterium, Rhodococcus, and Corynebacterium; 4 Actinobacteria as HGT Donors in Microbial Communities; 5 HGT and Genomic Heterogeneity Within Species; 6 Conclusions and Future Outlook; References; Photobacterium damselae: How Horizontal Gene Transfer Shaped Two Different Pathogenic Lifestyles in a Marine Bacterium; 1 Introduction; 2 P. damselae subsp. damselae: A Generalist Pathogen with High Genetic Diversity 2.2.4 ssDNA Integration into the Recipient dsDNA3 Transduction; 3.1 Specialized Transduction; 3.2 Generalized Transduction; 4 Conjugation; 4.1 F+ x F- Crosses in E. coli; 4.2 Genesis of Hfr Strains and Hfr (F+) x F- Crosses in E. coli; 5 Bacterial Vesicles as Possible Source of HGT; References; Alternative Ways to Exchange DNA: Unconventional Conjugation Among Bacteria; 1 Introduction; 2 Conjugation in Mycobacterium; 3 Conjugation in Streptomyces; 4 Conjugation in Mollicutes; 5 Conjugation in Thermus spp.; 6 Concluding Remarks; References 3.10 Listeria monocytogenes Toxins3.11 Helicobacter pylori Toxins; References; Genomic Islands and the Evolution of Multidrug-Resistant Bacteria; 1 Horizontal Gene Transfer of Resistance Genomic Islands; 2 GI3 in MDR Escherichia coli O104:H4; 3 SGI/PGI/AGI-Like GIs in MDR Salmonella enterica, Proteus mirabilis and Acinetobacter baumannii; 4 SCCmec in MDR Staphylococcus aureus; 5 GIs in MDR Pseudomonas aeruginosa; 6 Conclusions; References; Horizontal Gene Transfer and Genome Evolution in the Phylum Actinobacteria; 1 Introduction

Summary: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

Contents:
1. Biophysiology of the uterus: development, cyclic changes, menopause
2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization)
3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis
4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy
5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy
6. Menopausal Hormone Therapy. Contraceptives
7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies
8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen)
9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).

Summary: The nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.

Contents:
Chapter 1. Conventional Treatment Approaches in Hormonal Cancer Treatment and Challenges
Chapter 2. Concept of Nanomedicine in Endocrine Hormone Cancer Treatment
Chapter 3. Progress of Cancer Nanomedicine, Clinical Hurdles and Opportunities
Chapter 4. Emergence of Nanohybrids in Hormonal Cancer Targeted Therapy
Chapter 5. Conventional to Nanoscale-Based Carrier System in Management of Ovarian Cancer
Chapter 6. Pancreatic Cancer Nanoparticles Targeted Therapy via Epidermal Growth Factor Receptor
Chapter 7. Nanocarriers Based Targeted Therapies for Pancreatic Cancer and Challenges Ahead
Chapter 8. Pancreatic Cancer Treatment by Using of Theranostics Nanoparticles
Chapter 9. Nanomedicine Based Combinational Therapy for Breast Cancer
Chapter 10. Nano-Liposomal System for Breast Cancer Therapy
Chapter 11. Conventional to Nanotherapeutic Strategies against Triple-Negative Breast Cancer
Chapter 12. Effect of Thymoquinone and Its Delivery Through Using of Nanomedicine in Benign Prostatic Hyperplasia
Chapter 13. Concept of Nanotechnology in Management of Neuroendocrine Tumours
Chapter 14. Neurocognitive Underpinning of Neurological Disorders: The Role of Default Mode Network
Chapter 15. Neuroendocrine Carcinoma of The Endometrium: Conventional Treatment Approach to Nanomedicine
Chapter 16. Effective Luteinizing Hormone Drug Delivery by Gold Nanoparticles in Hormonal Cancer Treatment
Chapter 17. Regulatory Landscapes in Approval of Cancer Vaccines.

Summary: This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and longer use of hormone therapy. The malignancy finally forms castration-resistant prostate cancer (CRPC) despite the lack of testicular androgen. With advances in understanding of the molecular basis of hormone dependence and CRPC, many new androgen receptor-targeted agents have emerged. During the last decade, much evidence on hormone therapy has been accumulated in Japan. Interestingly, some of these findings are different from those reported from Western countries, suggesting ethnic variation in the outcome of hormone therapy. In the chapters of this book, expert authors provide exhaustive interpretations of the evidence recently reported from Japan and provide important Asian perspectives on hormone therapy for PCa. This work benefits not only Asian urologists but also their Western counterparts and all physicians and medical personnel who are involved in the treatment of PCa.

Contents:
Introduction.-History of Hormones and Endocrinology
I. Hormone biochemistry.-Hormones: Definitions.-Vertebrate Protein and Peptide Hormones.-Invertebrate protein and peptide hormones.-Hormones from Mevalonate: JH and Steroids.-Hormones Derived by Amino Acid Conversion.-Receptors.-II. Endocrine physiology.-Synthesis, Release, and Action.-Endocrine active organs.-Regulatory Patterns.-Endocrine Rock 'n Roll: Rhythms and Secretion
Evolution of the Endocrine System.-III. Hormones and medicine.-Diseases of the Endocrine System.-Boosting Performance-Legally or Not.-IV. Appendix.-A. Appendix.-B. References.-C. Index.

Contents:
Hospice Care: An Overview of Quality and Compassionate Care
Documentation: An Important Driver for Care and Coverage
Planning, Managing, and Coordinating Care
Hospice Diagnoses and Guidelines for Care
Hospice Conditions of Participation: Subpart B-Eligibility, Election, and Duration of Benefits
Hospice Conditions of Participation: Subpart F-Covered Services
State Hospice and Palliative Care Organizations.

Summary: "Hospice and Palliative Care for Companion Animals: Principles and Practice offers the first comprehensive reference to veterinary hospice and palliative care, with practical guidance and best practices for caring for sick and dying animals. Presents the first thorough resource to providing veterinary hospice and palliative care Offers practical guidance and best practices for caring for sick and dying animals Provides an interdisciplinary team approach, from a variety of different perspectives. Gives concrete advice for easing pets more gently through their final stage of life Includes access to a companion website with client education handouts to use in practice"-- Provided by publisher.

Contents:
Introduction
What is animal hospice and palliative care? / Amir Shanan and Tamara Shearer
The interdisciplinary team / Tammy Wynn and Amir Shanan
Quality of life in the animal hospice and palliative care patient / Jessica Pierce and Amir Shanan
Bond -centered animal hospice and palliative care / Laurel Lagoni and Amir Shanan
Ethical decision making in animal hospice and palliative care / Jessica Pierce and Amir Shanan
Animal hospice models of care / Kathleen Cooney
Prevalence of diseases, causes of death, and common disease trajectories in hospice and palliative care patients / Tamara Sheare
Cancers in dogs and cats / Alice Villalobos
Chronic kidney disease / Shea Cox
Congestive heart failure / Shea Cox
Respiratory distress / Cheryl Braswel
Gastrointestinal conditions / Shea Cox
Musculoskeletal disorders / Tamara Shearer
Nervous system disease / Tamara Shearer
Cognitive dysfunction / Tamara Shearer
Recognizing distress / Suzanne Hetts and Kristina August
Pharmacology interventions for symptom management / Shea Cox
Physical medicine, rehabilitation, and complementary and integrative medicine treatment modalities / Tamara Shearer and Kristina August
Balancing efficacy of treatments against burdens of care / Kristina August
Nursing care for seriously ill animals: art and techniques / Shea Cox and Mary Ellen Goldberg
Comfort care during active dying / Gail Pope and Amir Shanan
Euthanasia in animal hospice / Kathleen Cooney
Mental health considerations in caring for animal hospice and palliative caregivers and providers / Amir Shanan
Addressing spiritual needs of caregivers / Carol Rowehl
Supporting other needs / Shea Cox and Mary Ellen Goldberg
Aftercare / Coleen Ellis.

Summary: The Hospice Companion is an easy-to-navigate clinical decision support tool for caregivers of those with life-limiting illnesses. It features a thoroughly current guide to clinical processes and symptom management, providing hospice professionals with a concise summary of changes that have influenced clinical practice.

Contents:
General processes
Personal, social, and environmental processes
Clinical processes and symptom management.

Summary: "The overarching purpose of this manual, reflecting the essential goals of hospice, is to help maximize the quality of living and dying of patients during the last phase of life. It will be through disciplined clinical uniformity and standardized practices that personalized, tailored care can then be aptly applied. And with that, hopes for individual epiphany may have the chance to be realized as those who entrust their care to us meet their earthly ends. With due regard for the complexities of peoples' lives, especially during severe illness, it is premised that identification and understanding of discrete situations (intertwined and enmeshed as they may be) will promote the elaboration of a care plan that will have the greatest likelihood of meeting these worthy ends"-- Provided by publisher.

Summary: This book provides an unique resource for registered nurses working in hospice palliative care at home and for the community, outside of acute care settings and also incorporates literature related to palliative care in acute health care settings, as part of the overall services and supports required. Very few resources exist which specifically address hospice palliative care in the home setting, despite the fact that most palliative care occurs outside acute care settings and is primarily supported by unpaid family caregivers. An overview of the concerns for individuals and families, as well as specific nursing interventions, from all ages would be an excellent support for nursing students and practicing registered nurses alike. The book structure begins with a description of the goals and objectives of hospice palliative care and the nursing role in providing excellent supportive care. Chapters include research findings and specifically research completed by the authors in the areas of pediatric palliative care, palliative care for those with dementia, and the needs of family caregivers in bereavement. Interventions developed by the editors are provided in this book, such as the “Finding Balance Intervention” for bereaved caregivers; the “Reclaiming Yourself” tool for bereaved spouses of partners with dementia; and The Keeping Hope Possible Toolkit for families of children with life threatening and life limiting illnesses. The development and application of these theory-based interventions are also highlighted. Videos and vignettes written by family caregivers about what was helpful for them, provide a patient-and family-centered approach. The book will benefit nursing students, educators and practicing registered nurses by providing information, theory, and evidence from research. -- Provided by publisher.

Contents:
Chapter 1. Overview of Hospice Palliative Care in a Community and Home Setting (theoretical and conceptual models, populations, ages, diseases, transitions, bereavement support)
Chapter 2. The Formal Caregiver Perspective
Chapter 2. Global Perspectives from the UK
Chapter 3. The Family Caregiver Perspective
Chapter 3. Global Perspectives from Europe
Chapter 4. Global Perspectives: Nigerian Context
Chapter 5. Palliare (UK/Europe)
Chapter 6. Global Perspectives from Canada
Chapter 7. Global Perspectives: New Zealand
Chapter 8. Global Perspectives: US
Chapter 9. Global Perspectives: Conclusions
Chapters 10. Finding Balance
Chapter 11. Keeping hope possible
Chapter 12. Reclaiming Yourself
Chapter 13. Living with Hope
Chapter 14.COPE intervention for caregiver
Chapter 15. Dementia
Chapter 16. Heart Failure
Chapter 17. Older Adults with Cancer
Chapter 18. Long Term Care
Chapter 19. Prisons
Chapter 20. Pediatric Home Care
Chapter 23. Looking ahead.

Summary: This book offers the first comprehensive insight into hospital-based injury and violence prevention programs and describes a public health approach for the integration of population-based injury prevention into trauma centers. This book meets the need for a public health informed approach, as a majority of hospital-based injury and violence prevention programs are positioned within hospital systems driven by patient-centered, acute care models. Significant variability in administration, staffing and reimbursement structures across trauma centers has historically hindered standardization of injury prevention program structure and the role of the injury prevention professional. Topics in the book include the history and development of hospital-based programs, the need and process for developing data-driven and evidence-based injury prevention interventions, building trauma center capacity for outreach through partnerships, developing prevention efforts using trauma-informed care approach, community based research and program evaluation, and the role of advocacy in injury and violence prevention. The multidisciplinary team of authors offers a collaborative approach to the implementation and development of Hospital-based Injury and Violence Prevention Programs which will serve acute care nurses, trauma program managers, hospital administrators, trauma surgeons, hospital-based injury prevention professionals, and local public health professionals.

Contents:
Chapter 1. Introduction. The Role of Prevention in Comprehensive Trauma Care Systems
Chapter 2. History and Development of Hospital-based Injury Prevention
Chapter 3. Public Health Fundamentals for Hospital-based Programs
Chapter 4. Developing Data-Driven Programs: The value of data
Chapter 5. Ensuring an Evidence Based Approach to Injury Prevention Interventions
Chapter 6. Building Prevention Capacity through Community Partnership
Chapter 7. Addressing Cultural Competence in Hospital Based Programs
Chapter 8. Conducting Research in Community Injury Prevention
Chapter 9. Understanding the Role of Advocacy
Chapter 10. Making the Business Case for Hospital-based Injury and Violence Prevention Programs
Chapter 11. Resources for Hospital-based Injury and Violence Prevention Professionals.

Summary: "This book has nine chapters of accurate, relevant, and, most important, high-yield orthopaedic facts, organized by the subspecialties"--Provided by publisher.

Contents:
Arthroplasty
Sports
Pediatrics
Trauma
General/basic science
Tumors
Hand
Foot and ankle
Spine.

Contents:
I: Conditions of the hallux
II: Metatarsalgia and lesser toe deformity
III: Adult acquired flatfoot deformity
IV: Cavovarus foot deformity
V: Ankle arthritis
VI: Tendon disorders
VII: Stress fractures of the foot and ankle
VIII: Ankle trauma
IX: Foot trauma.

Summary: The art of medicine becomes science when supported by evidence. The recommended practices of infection prevention are based on scientific and epidemiologic evidence. However,most health care professionals see them as mandates and fail to incorporate them into their routine patient care activities. Thecore goal of this publication is to link the practices to theprinciples they are based on. The expectation is that understanding ofthe principles willchange thepractices from mandates to "should do" in the minds of health care professionals. This will lead to improvement inhealth care by preventing unintended harm to patients, co-workers and the communities at large. At the same time, the text provides a comprehensive, thorough and up to date information on all aspects of infection prevention in a reader-friendly manner and therefore, will serve as a valuable reference.

Contents:
The Mighty World of Microbes - An Overview
Vaccinations and infection prevention
Hospital Infection Prevention Program
Current practices for infection prevention in the hospital settings
Hospital Infection Prevention Program
The Role of Microbiology Laboratory in Infection Prevention
Role of Antimicrobial Stewardship in Infection Prevention
A Four step approach to Antibiotic stewardship in India: Formulation of antibiotic policy
Role of Hospital Housekeeping and Materials Management Including Disinfection and Waste Management
Hand Hygiene and Personal Protective Equipment
Decontamination and Sterilization Procedures
Monitoring of High Risk Areas - Intensive care units
Monitoring of High Risk Areas: Operating Suite
Monitoring of High Risk Areas: Maternity wards
Monitoring of High Risk Areas: Cancer wards
Monitoring of High Risk Areas: Dialysis Units
Monitoring of High Risk Areas: Burn units
Infection Prevention for Procedures in wards.

Summary: This practical resource provides hospitalists of all levels a comprehensive foundation for understanding the critical elements of hospital medicine. Beginning with an overview of the healthcare system, chapters provide relevant insights on management, regulations, evidence-based approaches, an awareness of safety and economic concerns and professional development skills. Perspectives on how hospitalist and hospital medicine teams can effectively engage this system to provide cost-effective, high-quality care are offered throughout this volume. With real-world guidance on the major tenets of hospital medicine, Hospital Medicine will serve as the definitive guide to a successful career in this rapidly evolving specialty.

Contents:
Primer on the healthcare system / Norman F. Retener and Andrew Delapenha
Knowing yourself and your style / Neda Frayha and Robert J. Habicht
Planning for a career in hospital medicine / Kathryn Novello Silva and Abel Joy
Common career pitfalls : real-world guidance of common mistakes to avoid that may impact a hospitalist's ability to be successful / Christopher Jason and Himati P. Patel
Goal setting : effective strategies to plan for a successful career / Christopher Jason and Lana R. Elpert
Work-life balance and preventing burnout / Lana R. Elpert and Lee-Ann Wagner
Women in medicine / Ada Ibe Offurum, Kathrun Novello Silva and Mangla S. Gulati
Basics of billing and coding : a primer for the new hospitalist attending / Himati P. Patel and Negin J. Ahadi
Incorporating evidence-based medicine into your daily life / Negin J. Ahadi and Robert J. Habicht
Interprofessional collaboration / Abel Joy and Philip C. Dittmar
Transitions of care / Danielle Y. Baek and Nidhi Goel
Patient experience / Brian E. Edwards and Christopher Jason
Consultative medicine and co-management / Lee-Ann Wagner and Saverio Mirarchi
Introduction to patient safety and quality / Mangla S. Gulati and Kathryn Novello Silva
Financial and regulatory drivers in health care / Mangla S. Gulati and Shiva K. Ganji
Demonstrating value and gaining visibility : 13 key questions to success / Ada Ibe Offurum
Cost-conscious care / Philip C. Dittmar and Brian E. Edwards
Managing from the middle / Ada Ibe Offurum
Teaching and feedback / Darlene Tad-y and Ethan Cumbler
Engaging others in patient safety and quality improvement / Darlene Tad-y and Patrick Kneeland
Introduction to research as an early career hospitalist / Nidhi Goel and Robert J. Habicht.

Contents:
Chapter 1: Introduction to Hospital Neurology
Chapter 2: Potential Harms to Physician and Patient
Chapter 3: General Care of the Hospitalized Patient
Chapter 4: Womenʹs Issues in Hospital Neurology
Chapter 5: Principles of Care for the Hospitalized Geriatric Patient
Chapter 6: Chronic Pain in Neurological Patients
Chapter 7: Infections of the Central Nervous System
Chapter 8: The Neurological Examination
Chapter 9: Neurophysiology
Chapter 10: Imaging
Chapter 11: Interpretation of Common Laboratory Tests
Chapter 12: Common Laboratory Diagnosed Conditions
Chapter 13: Stroke Neurology
Chapter 14: First-Time Seizure Episode and Status Epilepticus in Adults
Chapter 15: Neurotrauma and Myelopathies
Chapter 16: Neuromuscular Emergencies
Chapter 17: Movement Disorders Emergencies
Chapter 18: Some Common Neurological Emergencies
Chapter 19: Cardiovascular Emergencies on the Neurology Wards
Chapter 20: Airway and Respiratory Emergencies on the Neurology Ward
Chapter 21: Principles of Neurocritical Care
Chapter 22: Altered Mental Status
Chapter 23: Aphasia
Chapter 24: Spells, Not Epileptic or Vascular
Chapter 25: Approach to Acute Visual Changes, Abnormal Eye Movements, and Double Vision
Chapter 26: Dizziness and Vertigo
Chapter 27: Headache and Facial Pain
Chapter 28: Neurologic Patterns of Weakness
Chapter 29: Gait Disorders
Chapter 30: The Ataxias
Chapter 31: Epilepsy
Chapter 32: Rapidly Progressing Dementias
Chapter 33: Chronically Progressing Dementias
Chapter 34: Movement Disorders
Chapter 35: Perioperative Management
Chapter 36: Coma and Other States of Altered Consciousness
Chapter 37: Genetic Neurological Diseases in the Adult
Chapter 38: Spinal Cord Neurology
Chapter 39: Back, Neck, and Limb Pain
Chapter 40: Approach to Sensory Changes
Chapter 41: Neuropathies and Motor Neuron Disease
Chapter 42: Myopathies and Neuromuscular Junction Disease
Chapter 43: Demyelinating Diseases
Chapter 44: Common Tumors of the Nervous System
Chapter 45: Common Gastrointestinal and Hepatic Disorders
Chapter 46: Common Metabolic Problems on the Neurology Wards
Chapter 47: Common Cardiorespiratory Problems on the Neurology Ward
Chapter 48: Fever, Hypotension, and Reduced Urine Output
Chapter 49: Common Psychiatric Conditions
Chapter 50: Adverse Neurologic Effects of Commonly Used Medications
Chapter 51: Internal Medicine and Neurology
Chapter 52: Medication and Dosing.

Contents:
sect. 1. The development of sound personnel practices in hospitals
sect. 2. Conference techniques.

Summary: This book discusses the factors that contribute to the success of hospitals from a theoretical, practical and operational perspective to allow hospital managers both clinical and non-clinical at all levels to achieve success via a turnaround process where necessary. A robust performance management framework is detailed to make this success sustainable. Case studies where appropriate support the relevant chapters. Chapters can be read sequentially or as a stand-alone chapter. Hospital Transformation: From Failure to Success and Beyond enables readers to develop their hospital management skills. Issues of patient care, resource allocation, staff management, leadership, risk management, infection control, and financial sustainability are all covered. This book is relevant to hospital administrators, clinicians involved in hospital management, independent consultants, and healthcare providers responsible for day to day operations of healthcare facilities.

Contents:
Intro; Foreword; Preface; Contents; Contributors; Part I: Requirements of Basic Healthcare Globally;
1: Regulatory Requirements for Healthcare Globally; Introduction; Is Regulation of Healthcare Services Truly Global?; Structural Regulations; Licensing and Accreditation; Medical Regulatory Authorities; Evidence Based Medicine and Regulation; Quality Assurance and Regulation; Conclusion; References;
2: Opportunities and Challenges in Global Healthcare; Introduction; Global Healthcare Challenges; Population Demographics and Disease Pattern; Cost Control; Human Resources and the Workforce Medical EducationAccessibility and Rationalisation of Healthcare Services; Quality and Outcome Measures; Patient Centric Healthcare; Global Healthcare Opportunities; Investment; Teaching and Training; Research; Careers; Conclusion; References; Part II: Models of Healthcare Provision;
3: Models of Healthcare in Developed and Developing Countries; Introduction; The Beveridge Model; The Bismarck Model; The National Health Insurance Model; Private Insurance and Out of Pocket Model; What about the U.S.A.?; How Can Governments Choose the Best Model of Healthcare?; Conclusion; References Part III: Provision of Effective, Safe and Good Quality Car
e4: How Do Hospitals Deliver Safe, Effective and High Quality Care?; Leadership; Responsiveness; Culture; Sheffield Teaching Hospitals; Tees Esk and Wear Valley; Ashford and St Peter's Hospitals NHS Foundation Trust; Monitor; Sharing and Learning; Conclusions; References; Part IV: Identifying Failure;
5: Transforming Hospital Accreditation: From Assurance to Improvement; Data Driven Improvement; Types of Regulation; Problems with Current Hospital Accreditation Systems; A New Model for Accreditation; A New Approach to Safety Assurance The Implications of the New ModelConclusion; References;
6: Key Features in Identifying Failing Hospitals; Introduction; Leadership; Culture; Vision; Information Gathering and Management Systems; Planning Processes; Conclusion; References;
7: The Illness of the Health Care Systems; Introduction; Epistemological Issues; Science and Knowledge; Power Relations and the Political Economy; Alternatives, Approaches and Practical Implications; Conclusion; References;
8: The Political Economy of Health Reforms in Chile: A Case Study of the Privatization Process; Introduction; Theoretical Concerns Chilean Health Reforms and Negotiation Through HistoryThe Development of the Welfare State; The End of the Welfare State and a New Market Model; Conclusion; References; Part V: The Turnaround Process;
9: The Role of Medical Leadership in the Hospital Turnaround Process; Introduction; Who Are Medical Leaders?; Wider Context; How Can Medical Leaders Assist in the Turnaround Process?; Background; Strategic Objectives of Hospitals; The Medical Director in a Failing Hospital Undergoing Transformation; References;
10: Public Health Service Governance: Principles and Framework; About This Chapter

Summary: This practical guide provides the perspectives needed to treat acute and chronic pain in the hospital. Authored by experts of diverse specialty backgrounds, chapters bring the available evidence together with modern strategies for caring for patients with complex pain. Basic considerations and multimodal and multidisciplinary approaches with the greatest impact on minimizing suffering and burden of care are covered in detail. The material in this text will assist the learner, the teacher, and the life-long learning practitioner by providing basic considerations for treating acute and chronic pain in the hospital. This book may also serve as a quick reference, review manual or teaching tool by teachers on rounds.

Contents:
Preface
Introduction to the Chronic Pain Patient
Definitions
Acute Pain
Chronic Pain
Opioid-induced Hyperalgesia
History
Physical Examination
The SCRIPT History Template
Patient Reported Outcomes
Clinical and Experimental Tools for Measuring Pain
Case 1: High Dose Opioids & Multiple Pain Medications
Case 2: Buprenorphine
Case 3: Methadone
Case 4: Abdominal Pain
Case 5: Unknown Pain Source
Case 6: Sickle Cell Disease
Case 7: A Cancer Pain Crisis
Case 8: Spasticity & Pain
Case 9: Renal & Hepatic Disease
Case 11: Angry Patient
Case 12: Intrathecal Pain Pump
Case 13: Spinal Cord Stimulation
Case 14: Opioid Use Disorder
Case 15: Comorbid Psychological Condition
Case 16: Poor Prognosis in a Palliative Care Patient
Case 17: Management of a Pain/Dyspnea in an Actively Dying Patient
Opioids
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Acetaminophen
Local Anesthetics
NMDA Antagonists
Alpha-2 Agonists
Gabapentin & Pregabalin
Tricyclic Antidepressants & Serotonin-Norepinephrine Reuptake Inhibitors
Steroids
Cannabinoids
Peripheral Regional Anesthesia Blocks
Neuraxial Blocks
Vertebroplasty & Kyphoplasty
Surgical Interventions for Pain
Opioid and Non-Opioid Therapies in Palliative Care
Crisis Management and Refractory Pain
Transition to Outpatient Care & Readmissions
Opioid Tapering for Acute on Chronic Non-Cancer Pain. .

Contents:
Adaptation of Microbial Metabolism in Host/Pathogen Interaction. Metabolic Adaptation of Human Pathogenic / Ann Kathrin Heroven, Petra Dersch
Crosstalk between Metabolism and Virulence of / Klaus Heuner, Wolfgang Eisenreich
Metabolism of Intracellular / Peter Holtkötter, Michael Hensel
The Human Microbiome in Health and Disease / Cian Hill, R Paul Ross, Catherine Stanton, Paul W O'Toole
Mechanisms of Dysbiosis in the Inflamed Gut / Sebastian E Winter
Strategies for Nutrient Acquisition by during the Infection of Rice / Andrew J Foster, George R Littlejohn, Darren M Soanes, Nicholas J Talbot
New Inhibitors and Targets of Infectious Diseases. Outer Membrane Proteins as Potential Anti-infective Drug Targets in / Robert L Davies
Identification of Anti-infective Compounds Using Amoebae / Christopher F Harrison, Hubert Hilbi
Stress Biology in Fungi and "Omic" Approaches as Suitable Tools for Analyzing Plant-Microbe Interactions / Stefan Jacob, Alexander Yemelin
Targeting Plasmids: New Ways to Plasmid Curing / Anja Schüffler, Corinna Kübler
Regulation of Secondary Metabolism in the Gray Mold Fungus / Muriel Viaud, Julia Schumacher, Antoine Porquier, Adeline Simon.

Contents:
Galleria mellonella as an infection model for select agents / Nicolas Sprynski, Eric Valade, and Fabienne Neulat-Ripoll
Drosophila as a model for intestinal infections / Matthieu Lestradet, Kwang-Zin Lee, and Dominique Ferrandon
Zebrafish embryos as a model to study bacterial virulence / Jennifer Mesureur and Annette C. Vergunst
Studying host-pathogen interaction events in living mice visualized in real time using biophotonic imaging / Gary Splitter ... [et al.]
Intravital two-photon imaging to understand bacterial infections of the mammalian host / Ferdinand X. Choong and Agneta Richter-Dahlfors
Cre reporter assay for translocation (CRAfT) : a tool for the study of protein translocation into host cells / Amke den Dulk-Ras, Annette C. Vergunst, and Paul J.J. Hooykaas
Detection of the interaction between host and bacterial proteins : eukaryotic nucleolin interacts with Francisella elongation factor Tu / Monique Barel and Alain Charbit
Hijacking the host proteasome for the temporal degradation of bacterial effectors / Tomoko Kubori, Andree M. Hubber, and Hiroki Nagai
Live cell imaging of phosphoinositide dynamics during Legionella infection / Stephen Weber and Hubert Hilbi
Investigating interference with apoptosis induction by bacterial proteins / Hua Niu and Yasuko Rikihisa
Bimolecular fluorescence complementation for imaging protein interactions in plant hosts of microbial pathogens / Lan-Ying Lee and Stanton B. Gelvin
Investigating TLR signaling responses in murine dendritic cells upon bacterial infection / Suzana Pinto Salcedo and Lena Alexopoulou
siRNA screens using Drosophila cells to identify host factors required for infection / Aseem Pandey ... [et al.]
Purification of intracellular bacteria : isolation of viable Brucella abortus from host cells / Esteban Chaves-Olarte ... [et al.]
RNA sequencing of FACS-sorted immune cell populations from zebrafish infection models to identify cell specific responses to intracellular pathogens / Julien Rougeot ... [et al.]
Taking the shortcut for high-throughput shotgun proteomic analysis of bacteria / Erica Marie Hartmann ... [et al.]
Comparative genomic analysis at the PATRIC, a bioinformatic resource center / Alice R. Wattam ... [et al.]
Markerless deletion method for genetic manipulation of Burkholderia cenocepacia and other multidrug-resistant gram-negative bacteria / Daniel F. Aubert, Mohamad A. Hamad, and Miguel A. Valvano
Gene inactivation in Coxiella burnetii / Paul A. Beare and Robert A. Heinzen
Chemical mutagenesis approach to identify virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis / Bidong Nguyen and Raphael Valdivia.

Summary: This book is about the theory of Hot and Cold, a mutual fundamental base of traditional medicines all around the world. The theory describes the dynamic balance state of the body on the axis of hot and cold for each individual and proposes the fact that deviation from this equilibrium is a predisposing factor for diseases. Such an approach helps practitioners to provide treatments tailored to the patients condition, not the disease. This book, for the first time, has gathered native descriptions of Hot and Cold theory in different traditional medicines, including traditional Chinese medicine, Persian (Humoral, Unani) medicine, Ayurvedic medicine and Latin American and Caribbean medicines. After defining the common ground, contemporary research - in nutrition, pharmacology, physiology and systems biology - has been explored using scientific methodology. This work is the result of an international collaboration of more than 30 scientists and scholars with high reputations in their fields. Hot and Cold theory, as a holistic individualized approach in prevention, diagnosis and treatment, can be merged into the novel fast-paced concepts in systems biology and precision medicine. Through this bridge, the authors propose that the Hot and Cold theory should be revisited more deeply by medical scientists, who are the main audience of this book, to pave the way towards integrated holistic personalized medicine.

Contents:
1. Introduction
PART I: DEFINITIONS AND BELIEFS
2. Principle of Hot and Cold and its Clinical Application in Traditional Chinese Medicine
3. Principle of Hot and Cold and its Clinical Application in Persian Medicine
4. Principle of Hot (Ushna) and Cold (Sheeta) and its Clinical Application in Ayurvedic Medicine
5. Principle of Hot and Cold and its Clinical Application in Latin American and Caribbean Medicines
PART II: SCIENTIFIC EVIDENCE
6. Hot and Cold Theory: Evidence in Nutrition
7. Hot and Cold Theory: Evidence in Pharmacology
8. Hot and Cold Theory: Evidence in Physiology
9. Hot and Cold Theory: Evidence in Systems Biology
PART III: PERSPECTIVE
10. Hot and Cold Theory: A Personalized Medicine Approach
11. Hot and Cold Theory: Future Perspective.

Contents:
Biomedical materials science / Ifty Ahmed
Photopolymerizable hydrogels in regenerative medicine and drug delivery / Rúben F. Pereira & Paulo J. Bártolo
Micro- and nano-modified surfaces for better polymeric implants / Vasif Hasirci
Bionanomaterials : current developments to prevent biofilm formation by Candida species / Mayra Cuéllar-Cruz, Daniel Hernández-Cruz, Everardo López-Romero & Arturo Vega-González
Bioactive glasses : traditional and prospective applications in healthcare / Wei Li & Aldo R. Boccaccini
Biomaterials in spine surgery : the goal of enhancing spinal fusion / Sabrina A. Gonzalez-Blohm, James J. Doulgeris & Frank D. Vrionis
Biomedical materials for cardiovascular stents / Kadem Al-Lamee & Rasha Al-Lamee
PEGylated ceramic nanophosphors : latest developments and applications / Masao Kamimura & Yukio Nagasaki
Development of phosphate-based glass fibers for biomedical applications / Kazi M. Zakir Hossain, Muhammad Sami Hasan, Reda Felfel & Ifty Ahmed
Index.

Summary: The latest edition of this must-have text book promises an evidence-based and practical approach covering the very latest in cardiorespiratory care. The textbook covers a wide range of cardiorespiratory conditions and discusses treatment of patients in different clinical settings such as critical care, the ward area and out-patient departments. It begins with physiology and pathology and progresses into a detailed patient assessment section and a discussion of specific respiratory and cardiac conditions. The final section covers different groups of people who may require physiotherapy such as infants, children, and adults with specific conditions including a considered section on palliative care. Critical thinking is facilitated by clinical reasoning boxes in the text, and problem-solving is aided by case studies at the end of each chapter. There are also relevant practice tips to enable transfer of learning into the clinical environment. The text is supported by over 280 line drawings and diagrams along with over 70 x-rays and photographs to further illustrate the points under discussion. Authoritative and accessible, the new fifth edition of Hough's Cardiorespiratory Care continues to stimulate critical thought and ensure that practice is evidence based. The logical format and analytic style encourages clinical reasoning, and the problem-solving approach makes it suitable for readers from student to advanced practitioner level. Integration of theory and practice is aided by extensive referencing, and specialist contributors provide thought-provoking chapters on cardiovascular management, paediatric/neonatal physiotherapy, and critical care. New for the fifth edition: expanded cardiovascular section; updated practical details on physiotherapy techniques; extra chapters on surgical complications and interventions; comprehensive coverage of critical care procedures and rehabilitation; practicalities of the management of children and infants; update on the evaluation of outcomes. Key features: Q&A case studies, with scans and x-rays; outcome measures for problems and diseases; boxes with learning and practice tips to encourage reflection; tables with definitions, normal values and comparisons; practical techniques described with precision. Online resources: image bank; references; bibliography; appendices, including guidelines for health professionals, links for patients, and further case studies. -- From back cover.

Contents:
Part I Physiology and pathology. 1. Physiological basis of clinical practice ; 2. Assessment ; 3. Respiratory disorders ; 4. Cardiovascular disorders ; 5. General management
Part II Physiotherapy techniques. 6. Physiotherapy to increase lung volume ; 7. Physiotherapy to clear secretions ; 8. Physiotherapy to decrease the work of breathing ; 9. Pulmonary rehabilitation ; 10. Physiotherapy for people with cardiovascular disorders ; 11. Cardiac rehabilitation
Part III Surgery. 12. Complications ; 13. Physiotherapy for surgical patients ; 14. Modifications for different types of surgery
Part IV Physiotherapy for specific groups of people. 15. Infants ; 16. Children ; 17. Hyperventilation syndrome ; 18. Elderly people with cardiorespiratory disease ; 19. Palliative respiratory physiotherapy
Part V Critical care ; 20. Critical care, support and monitoring ; 21. Physiotherapy for critically ill patients ; 22. Modifications for different disorders
Part VI Does it work?. 23. Evaluation of cardiorespiratory physiotherapy.

Contents: <br/
>6. Dietary levels of households in the United States, Spring, 1965.

Summary: This concise, ground-breaking book expands past theories limited to the cerebral cortex and emphasizes the longitudinally-integrated brainstem systems that 'wake up the brain' from deep anesthesia, sleep and brain injury. For neurologists, neuroscientists, psychologists and psychiatrists, as well as readers interested in the workings of the brain.

Contents:
Introduction
Concept
Giant cells in the medullary reticular formation
Pons
Midbrain
Hypothalamus: low road
Thalamus: high road
High arousal
Phase transitions from low GA states
Roots of consciousness and its disorders
A vertically integrated system.

Summary: This open access book offers an overview of theories related to simulation and describes different simulation areas within nursing. It illustrates how simulation may be used in different levels in professional education. The book deals with the role of the Simulation Facilitator, peer learning and the use of Virtual Reality in simulation. It provides new insights and paths to the development of the use of simulation within nursing and healthcare and contributes with new knowledge from research and experiences of implementation of different simulating scenarios within nursing and midwifery. It is intended to teachers in nursing and other healthcare professionals with an interest in the use of active learning methods. -- Provided by publisher.

Contents:
Chapter 1. Simulation: A historical and pedagogical perspective
Chapter 2. How to use simulation as a learning method in bachelor and postgraduate/master education of nurses and teachers in healthcare
Chapter 3.Facilitating learning activities in further education and master's program in oncology nursing
Chapter 4. Simulating preoperative preparations with focus on non-technical skills in an OR nursing education program in Norway
Chapter 5. Training Interprofessional Teamwork in Palliative Care: A Pilot study of Online Simulation Activity for Registered Nurses and Nursing Associates
Chapter 6. The use of Critical Response Process as a debriefing structure in simulation activity in nursing education
Chapter 7. Learning without a teacher: perceptions of peer-to-peer learning activities in simulation training
Chapter 8. Train the trainer course
How can the skills of a facilitator benefit academic staff in nursing and other health education programmes
Chapter 9. Playful learning with VR- SIMI model- the use of 360-degree video as a learning tool for nursing students in a psychiatric simulation setting
Chapter 10. Virtual Reality (VR) in anatomy teaching and learning in higher healthcare education.

Summary: "A poignant and thought-provoking memoir following one psychiatrist and four of her patients as they deal with the unspoken mental and physical costs of caring for others--perfect for fans of Maybe You Should Talk to Someone and The In-Between."-- Provided by publisher.

Summary: This book examines the role of fermented foods on human gut health and offers a unique contribution to this rapidly growing area of study. Fermented foods have been consumed by humans for millennia. This method of food preservation provided early humans with beneficial bacteria that re-populated the gut microbiota upon consumption. However, novel methods of production and conservation of food have led to severed ties between the food that modern humans consume and the gut microbiota. As a consequence, there has been a documented increase in the prevalence of autoimmune diseases and obesity, which has been correlated to decreased diversity of gut microbes, while infectious disorders have decreased in the three past decades. With the intention of providing a thorough overview of the relationship between fermented foods, nutrition, and health, the editors have grouped the chapters into three thematic sections: food and their associated microbes, the oral microbiome, and the gut microbiome. After an introduction dedicated to the environmental microbiome, Part I provides an overview of what is currently known about the microbes associated with different foods, and compares traditional forms of food preparation with current industrial techniques in terms of the potential loss of microbial diversity. The chapters in Part 2 explore the oral microbiota as a microbial gatekeeper and main contributor to the gut microbiota. Part 3 introduces beneficial modulators of the gut microbiome starting with the establishment of a healthy gut microbiota during infancy, and continuing with the role of probiotics and prebiotics in health preservation and the imbalances of the gut microbiota. In the final section the editors offer concluding remarks and provide a view of the future brought by the microbiome research revolution. This study is unique in its emphasis on the convergence of two very relevant fields of research: the field of studies on Lactic Acid Bacteria (LAB) and fermented foods, and microbiome research. The relationship between these fields, as presented by the research in this volume, demonstrates the intimate connection between fermented foods, the oral and gut microbiota, and human health. Although research has been done on the impact of diet on the gut microbiome there are no publications addressing the restorative role of food as microbe provider to the gut microbiota. This novel approach makes the edited volume a key resource for scientific researchers working in this field.

Contents:
Introduction: The environmental microbiome and the interdependence of all life
Rob Dunn Part 1
Foods and their associated microbesChapter 1. Infant nutrition: The microbiome of breast milk
Alison Stuebe Chapter 2. Dairy: Cheese and yogurt
Jose M. Bruno-Barcena Chapter 3. Breads
Maria De Angelis or Marco GobbettiChapter 4. Meats
Silvina Fadda Chapter 5. Vegetables
Ilenys DiazChapter 6. Current methods of production and conservation of food
Jose M. Bruno-Barcena Part 2
The oral microbiome as gatekeeperChapter 1. The healthy oral microbiota
Roland Arnold Chapter 2. Dysbioses of the oral microbiota and disease
Apoena RibeiroChapter 3. The role on uncultivable organisms in oral health
Flavia TelesChapter 4. The oral microbiome and health implications
Eva Helmerhorst Part 3
Gut MicrobiomeChapter 1. Early gut microbiome, a good start in nutrition and growth may have lifelong lasting consequences
Amanda ThompsonChapter 2. Probiotics
Todd Klaenhammer Chapter 3. Prebiotics
Jens Walter Chapter 4. The disappearing microbiota: Diseases of the Western civilization
M. Andrea Azcarate-PerilChapter 5. Infectious diseases and Antibiotics
Sophia KathariouChapter 6. The future: Personalized nutrition
Lawrence David.

Contents:
Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis / Kalsbeek, A.; Bruinstroop, E.; Yi, C.-X.; Klieverik, L.; Liu, J.; Fliers, E.
The blood-brain barrier as a regulator of the gut-brain axis / Schaeffer, M.; Hodson, D.J.; Mollard, P.
The brain modulates insulin sensitivity in multiple tissues / Parlevliet, E.T.; Coomans, C.P.; Rensen, P.C.N.; Romijn, J.A.
The important role of sleep in metabolism / Copinschi, G.; Leproult, R. ; Spiegel, K.
Metabolic interplay between gut bacteria and their host / Duca, F.; Giard, P.; Covasa, M.; Lepage, P.
The brain-stomach connection / Folgueira, C.; Seoane, L.M.; Casanueva, F.F.
Prader-Willi syndrome as a model of human hyperphagia / Tauber, M.; Diene, G.; Mimoun, E.; Aabal-Berthoumieu, S.; Mantoulan, C.; Molinas, C.; Muscatelli, F.; Salles, J.P.
Interactions between the gut, the brain and brown adipose tissue function / van den Beukel, J.C.; Grefhorst, A.
Gut sweet taste receptors and their role in metabolism / Meyer-Gerspach, A.C.; Wilnerhanssen, B.; Beglinger, C.
What is the role of metabolic hormones in taste buds of the tongue / Cai, H.; Maudsley, S.; Martin, B.
Protein PYY and its role in metabolism / Price, S.L.; Bloom, S.R.
Nutropioids regulate the gut-brain circuit controlling food intake / Mithieux, G.
Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? / Delhanty, P.J.D.; Neggers, S.J.; van der Lely, A.J.
Obestatin : is it really doing something? / Trovato, L.; Gallo, D.; Settanni, F.; Gesmundo, I.; Ghigo, E.; Granata, R.

Summary: "Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"--Publisher's description.

Contents:
The role of antibody in parasitic helminth infections
Maternal helminth infections
Helminth-M. tb co-infection
Bacterial infections and vaccines
Helpful or a hindrance: co-infections of helminth during malaria
Immune system modulation by helminth infections: potential impact on HIV transmission and disease progression.

Summary: "This book is an excursion into the drug development process, from the initial conception in a chemical or molecular biology lab, via tests in isolated cells and animals, to the stage of clinical trials. The human body is a complex ecosystem where little is conclusively known in terms of its response to medication, for both sick and healthy individuals. The considerable degree of uncertainty inherent in health-related research can lead to approval of controversial medicines, particularly in high-stakes scenarios and medical crises. Real-life examples are drawn on here to explain the decision making processes behind the acceptance of new drugs, disproving misconceptions around medicines by delving into the history and current practice of the drug development process. Originally written in Italian, How Medicines are Born helps patients, students, public health officials physicians, healthcare practitioners and biomedical scientists make informed decisions on the benefits and disadvantages of select medicine based on an understanding of the history of drug development. Published in Italian (2014), M D'Incalci et L Vozza, Come Nascono le Medicine; La scienza imperfetta dei farmaci. Bologna: Zanichelli"--Publisher's website.

Contents:
To cure, heal or repair
Hunting for drugs
Laboratory studies
First time in humans
Only probabilities, never certainties
Approval or rejection
Vigilance, revisions, new indications
Predicting the drugs of the future
Not every pill is a proper drug
If you want to know more
Myths to be dispelled
Did you know that.

Summary: Writing a medical paper, or any other scientific text, is full of pitfalls which make it difficult to get it accepted for publication. This unique book gives practical advice on how one can circumvent these dangers. It is richly filled with examples, predominantly negative ones. which exhibit how one should not write a medical paper. This book highlights the fallibilities that manuscripts are often susceptible to, and hence will help writers avoid committing those mistakes. Special Features: Abundant information about a complex subject condensed in a small format Numerous examples from bad man.

Contents:
Introduction
Why editors accept/reject manuscripts
Types of scientific articles
Manuscript components: dos and don'ts
Review process and corrections
Publication ethics
Good-to-know
Final advance
References.

Summary: Writing a medical paper, or any other scientific text, is full of pitfalls which make it difficult to get it accepted for publication. This unique book gives practical advice on how one can circumvent these dangers. It is richly filled with examples, predominantly negative ones. which exhibit how one should not write a medical paper. This book highlights the fallibilities that manuscripts are often susceptible to, and hence will help writers avoid committing those mistakes. Special Features: Abundant information about a complex subject condensed in a small format Numerous examples from bad man.

Contents:
Introduction
How to use this book
Why editors accept/reject manuscripts
Types of scientific articles
Manuscript components: dos and don'ts
Review process and corrections
Publication ethics
Good-to-know
Glossary
Final advice
References.

Summary: "How Psychotherapists Live is a landmark study of thousands of mental health practitioners worldwide. It significantly advances our understanding of psychotherapists and counselors by focusing on their individual qualities and lives, revealing the many ways they differ as persons and how those differences shape their experiences of therapeutic work. Topics include the therapist's personal self, private life, individual beliefs, quality of life, childhood family experiences, and personal psychotherapy. Based on thirty years of research, the book is written to interest clinical practitioners while also providing researchers with a rich array of data. Clinical psychologists, psychiatrists, clinical social workers, and counselors can easily compare their own experiences with the thousands of therapists in the study by reflecting on typologies constructed from research findings. The book will also be a valuable resource for researchers studying the sources of variation in therapists' effectiveness"-- Provided by publisher.

Contents:
1. An overview
2. The innate immune system
3. B cells and antibodies
4. The magic of antigen presentation
5. T cell activation
6. T cells at work
7. Secondary lymphoid organs and lymphocyte trafficking
8. Restraining the immune system
9. Self tolerance and MHC restriction
10. Immunological memory
11. The intestinal immune system
12. Vaccines
13. The immune system gone wrong
14. Immunodeficiency
15. Cancer and the immune system.

Summary: How the Immune System Works is not a comprehensive textbook. It's the book thousands of students have used to help them understand what's in their big, thick, immunology texts. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. Fifteen easy to follow lectures, featuring the uniquely popular humorous style and engaging analogies developed by Dr Sompayrac, provide an introduction to the 'bigger picture', followed by practical discussion on how each of the components interacts with one another.

Contents:
The innate immune system
B cells and antibodies
The magic of antigen presentation
T cell activation
T cells at work
Secondary lymphoid organs and lymphocyte trafficking
Restraining the immune system
Self tolerance and MHC restriction
Immunological memory
The intestinal immune system
The immune system gone wrong
Immunodeficiency
Vaccines
Cancer and the immune system
Immunotherapy.

Contents:
The Innate Immune System
B Cells and Antibodies
The Magic of Antigen Presentation
Activating T Cells
T Cells at Work
Secondary Lymphoid Organs and Lymphocyte Trafficking
Restraining the Immune System
Tolerance Induction and MHC Restriction
Immunological Memory
The Intestinal Immune System
The Immune System Gone Wrong
Immunodeficiency
Vaccines
Cancer and the Immune System
Immunotherapy
COVID-19 and the Immune System.

Summary: How the NIH Can Help You Get Funded takes a novel, non-formulaic approach in teaching readers how to "write a grant" -- and much more. The authors draw on their decades of experience working with both investigators and NIH personnel to anticipate their questions and concerns and help establish a comfortable, productive partnership between them. The authors advise readers on developing each component of the grant application in order of the components' influence on the final impact score. Individual funding mechanisms are reviewed along with grantsmanship tips specific to each. Readers learn the importance of reviewer-friendly formatting and organization of the text. The final chapters cover next steps after the application has been submitted-before, during, and after the review and funding decision. Strategies for resubmitting or repurposing applications are provided for those readers whose applications do not receive awards. The authors likewise anticipate the needs of readers who do receive funding but have questions on managing and maintaining their award. Amid ever-increasing competition for government research grants, How the NIH Can Help You Get Funded is an invaluable manual for how to pursue -- and sustain -- NIH funding.

Contents:
National Institutes of Health
Institutes and centers
Center for scientific review and the peer review process
Office of Extramural Research
Federal budget process
NIH funding data and trends
Getting at mechanism
Telling your story well
Presenting your message well
Getting by with a little help from your friends
Before and after your study section meets
Is the check in the mail?
The check is not in the mail
The check is in the mail but.

Summary: "'The only way to undo racism is to consistently identify and describe it -- and then dismantle it.' Ibram X. Kendi's concept of antiracism reenergizes and reshapes the conversation about racial justice in America -- but even more fundamentally, points us toward liberating new ways of thinking about ourselves and each other. In How to Be an Antiracist, Kendi asks us to think about what an antiracist society might look like, and how we can play an active role in building it. In this book, Kendi weaves an electrifying combination of ethics, history, law, and science, bringing it all together with an engaging personal narrative of his own awakening to antiracism. How to Be an Antiracist is an essential work for anyone who wants to go beyond an awareness of racism to the next step: contributing to the formation of a truly just and equitable society."-- Provided by publisher.

Contents:
Definitions
Dueling consciousness
Power
Biology
Ethnicity
Body
Culture
Behavior
Color
White
Black
Class
Space
Gender
Sexuality
Failure
Success
Survival.

Contents:
What is employability and what does it mean for you? / Lisa Taylor
Career planning and management / Adrienne Jolly
Professionalism / Rosemarie Mason
Continuing professional development (CPD) / James Gazzard
Leadership / Neil Sellen
Service improvement / Jon Larner
Business skills / David Dowdeswell Allaway
The job application process / Stephanie Allen
Consolidation of learning chapter and moving forward.

Summary: This book discusses personal traits and rationale for any student considering a career in surgery. The authors review accomplishments as a medical student that are key components of beginning a surgical career, and highlight what makes a student competitive for a surgical program. While much of the focus is on an academic career in surgery, sections are devoted to mentorship, research experience and personal experiences that lead to success and are relevant to anyone pursuing a surgery. The editors also focus on gender and work-life balance issues that are often perceived as barriers to a career in surgery. A How To Guide For Medical Students provides help to medical students interested in pursuing a career in surgery. The chapters also include key dates and sample application information for students to use as templates.

Contents:
Part 1. Clinical Training and Making Sure Surgery is Right for You
Part 2. Building a Portfolio for Success
Part 3. The Residency Search and Match
Part 4. Appendices.

Summary: "In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm"-- Provided by publisher. "Nutrition and lifestyle choices hold implications for general health, as well as real and potential effects on fertility and reproductive health. While the effects of diet on health and risk of chronic disease have been well described, there is relatively little research on fertility per se. It is likely that the majority of men and women with sub-fertility, regardless of weight, have a form of intrinsic insulin resistance that underlies the downstream effects on oocyte and sperm quality (Dunaif, et al., 1989). Insulin resistance results in compensatory hyperinsulinaemia, which plays an important role in all the manifestations of sub-fertility, including androgen excess, inflammation and anovulation in women with polycystic ovarian syndrome (PCOS)"-- Provided by publisher.

Contents:
Machine generated contents note: 1. The effects of nutrition and micronutrients on reproductive success Mu Li, Kyra Sim, Adrienne Gordon and Jennie Brand-Miller; 2. The effects of stress on conception and pregnancy Jeremy J. Cottle, Jacky Boivin and Alice D. Domar; 3. Preparing for IVF: an endocrine perspective Clare Bothroyd; 4. Assessment of endometriosis before conception Endah Rahmawati, Chien-Wen Chen, Yu-Wen Chen, Chang-Chih Hsieh, Pei-Chun Ma, Shun-Jen Tan and Chii-Ruey Tzeng; 5. Assessment of pelvic abnormalities prior to assisted reproduction Anusch Yazdani; 6. Immunological preparation, including vaccinations and microbiome management, prior to ART Ashley Gilman and William Buckett; 7. Optimising body weight to improve reproductive success Kelton Tremellen; 8. Lifestyle modifications
alcohol, caffeine, smoking, drugs before ART V. Nisenblat and M. Johnson; 9. Environmental factors to consider prior to conception Mark P. Green and Alexandra J. Harvey; 10. Pre-pregnancy genetic carrier screening Saioa Torrealday, Kyle J. Tobler and Pasquale Patrizio; 11. The optimal age for childbearing Rina Fyfe and Jon Hyett; 12. Alternative therapies to improve conception rates Caroline A. Smith and Mike Armour; 13. Preconception lifestyle modification of decidua to decrease early pregnancy loss: feeding the endometrium Alexandra Kermack, Ka Ying Bonnie Ng and Nick Macklon; 14. Antenatal factors that may contribute toward the development of polycystic ovary syndrome Roy Homburg and Panagiota Filippou.

Contents:
1. How to access the cephalic vein using a cut-down approach
2. Extrathoracic subclavian vein access
3. Subcutaneous implantable cardioverter-defibrillator
4. Internal jugular venous access and lead implantation for cardiac implantable electronic devices
5. Implantation of the left ventricular lead
6. How to place a lead in the azygos vein
7. Alternative site pacing: a guide to implantation techniques
8. How to maximize CRT response at implant
9. How to perform sub-pectoral device implants
10. Device extractions
11. How to extract pacemaker and defibrillator leads from the femoral approach
12. How to extract leadds form the jugular approach
13. How to perform venoplasty for access
14. How to perform defibrillation threshold testing
15. Use of chest X-ray, computed tomography and 3-D imaging to evaluate lead location
16. How to evaluate postoperative device complications
17. How to program pacemakers for patients with sinus node disease
18. How to interpret pacemaker electrocardiograms
19. How to perform pacemaker troubleshooting
20. How to program an ICD to program ATP, and program for VT/VF storm
21. How to troubleshoot an ICD
22. Management of ICD device and lead failures and recalls
23. How to program an ICD to minimize inappropriate shocks
24. How to perform CRT optimization
25. How to manage device infections and when to reimplant after device extraction
26. How to implement a remote follow-up program for patients with cardiac implantable electronic devices
27. How to set up an HF monitoring service
28. How to deactivate cardiac implantable electric devices in patients nearing the end of life and/or requesting withdrawal of therapies.

Contents:
Tackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics
Epidemiology of Staphylococcus aureus nasal carriage patterns in the community
Diagnostics and resistance profiling of bacterial pathogens
Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections
Anti-virulence strategies to target bacterial infections
Strategies to block bacterial pathogenesis by interference with motility and chemotaxis
New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy
History of antibiotics research
Actinobacteria and Myxobacteria
Two of the most important bacterial resources for novel antibiotics
Exploitation of fungal biodiversity for discovery of novel antibiotics
Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies
New structural templates for clinically validated and novel targets in antimicrobial drug research and development
Synthesis of antibiotics
Antibiotics clinical development and pipeline
Anti-infectives in drug delivery
overcoming the Gram-negative bacterial cell envelope.

Summary: The systematic review is a rigorous method of collating and synthesizing evidence from multiple studies, producing a whole greater than the sum of parts. This textbook is an authoritative and accessible guide to an activity that is often found overwhelming. The authors steer readers on a logical, sequential path through the process, taking account of the different needs of researchers, students and practitioners. Practical guidance is provided on the fundamentals of systematic reviewing and also on advanced techniques such as meta-analysis. Examples are given in each chapter, with a succinct glossary to support the text. This up-to-date, accessible textbook will satisfy the needs of students, practitioners and educators in the sphere of healthcare, and contribute to improving the quality of evidence-based practice. The authors will advise some freely available or inexpensive open source/access resources (such as PubMed, R and Zotero) to help students how to perform a systemic review, in particular those with limited resources.

Contents:
Intro
Contents
1: Introduction
1.1 How to Read This Book
References
2: A Brief History of the Systematic Review
2.1 Literature Past and Present
2.2 A Man with a Mission
2.3 Hierarchy of Evidence
2.4 The Rise of the Systematic Review
2.5 Numbers Are Not Enough
2.6 Conclusion
References
3: The Aim and Scope of a Systematic Review: A Logical Approach
3.1 Aim of a Review
3.2 PICO
3.3 Types of Review Questions
3.4 Eligibility Criteria
3.5 Inclusion Versus Exclusion
References
4: Searching the Literature 4.1 An Initial Foray
4.2 Facet Analysis
4.3 Sources
4.4 Using PubMed
4.4.1 Index Terms
4.4.2 Text Words
4.4.3 Truncation and Wildcards
4.4.4 Conditioning the Search
4.4.5 Filtering
4.4.6 Using PubMed
4.5 Running and Recording Your Search
4.6 Other Data Sources
4.6.1 Google Scholar
4.6.2 Grey Literature
4.6.3 Reference Management
4.7 Conclusion
References
5: Screening Search Results: A 1-2-3 Approach
5.1 Reference Management Software
5.2 Three Stages of Screening
5.3 Screening Form
5.4 Sharing the Load 5.5 Flowchart
5.6 Reporting the Screening Outcome
References
6: Critical Appraisal: Assessing the Quality of Studies
6.1 Assessing Quality
6.2 Critical Appraisal
6.3 Hierarchies of Evidence
6.4 Quality of Reporting
6.5 Methodological Quality of Studies
6.6 Risk of Bias
6.7 Choosing a Tool
6.7.1 Study-Level Assessment
6.7.2 Randomised Studies: Cochrane Risk of Bias Tool-2
6.7.3 ROBINS-I
6.8 Reliability and Validity
6.8.1 Reliability
6.8.2 Validity
6.9 Qualitative Studies 6.9.1 Why Might Reliability and Validity Apply Differently in Qualitative Research?
6.10 Risk of Bias in Qualitative Research: Dependability and Credibility
6.11 How to Use Your Appraisal Results
6.12 What's Next?
6.12.1 Narrative Assessment
6.12.2 Sensitivity Analysis
6.12.3 Restriction to Higher-Quality Studies
6.13 Conclusion
References
7: Reviewing Quantitative Studies: Meta-analysis and Narrative Approaches
7.1 Types of Quantitative Research
7.2 The Logic of Quantitative Research
7.3 More About p-values 7.3.1 Why the p-value Is Not the Probability That the Result Is Due to Chance, and the Probability of Getting Your Result May Be Zero
7.4 Statistical Errors
7.5 Introducing Meta-analysis
7.6 Extracting the Data
7.7 Calculate a Pooled Estimate of the Effect
7.7.1 Interpreting Standardised Effect Sizes
7.8 Vote Counting
7.9 Models of Meta-analysis
7.10 Weighting
7.11 Assess the Heterogeneity of the Results
7.12 Investigating Heterogeneity: Subgroup Analysis and Meta-regression
7.13 Forest Plots
7.14 Publication Bias and Funnel Plots

Summary: This structured dynamic book outlines, step by step, an evidence-based systematic approach to the sonographic evaluation of the pelvis in women with suspected endometriosis. This “how to” guide is intended for those with basic ultrasonography skills who want to further develop their capabilities in performing the relevant sonographic techniques to identify endometriosis. Detailed schematics, and corresponding high-resolution ultrasound images and intuitive videos support readers in expanding their technical skills and bridging the gaps in their knowledge of endometriosis ultrasound. The International Deep Endometriosis Analysis (IDEA) group consensus statement was the culmination of the work of 29 authors from 5 continents. With the publication of How to Perform Ultrasonography in Endometriosis the authors intend to provide the basis for quality improvement and benchmarking of ultrasound in the world of endometriosis. This book not only offers sonologists, radiologists and sonographers valuable insights into the field of endometriosis ultrasound, but also enables them to develop their practical skills in assessing women with chronic pelvic pain.

Summary: The last step in the IVF treatment cycle, embryo transfer, is also the process with the highest failure rate. No matter how good the laboratory technique is, a successful pregnancy will not be achieved without meticulous preparation of the uterus to accept the embryo. This book reviews the scientific evidence on endometrial receptivity, including histological, hormonal, biochemical, and immunological factors. Practical and concise, it supports gynecologists and embryologists to make evidence-based decisions that can influence the success rates of implantation and live births. Part of a series of books offering treatments and strategies for fertility and conception to optimize IVF outcomes, this volume is for all clinicians and embryologists working in reproductive medicine.

Contents:
Physiology of endometrial development through the cycle and implantation / Annabelle Brennan and Martha Hickey
Molecular and cellular basis of human embryo implantation / Guiying Nie and Eva Dimitriadis
Protein biomarkers of endometrial receptivity / Tracey A. Edgell
Genetic markers of endometrial receptivity (GMER) / Patricia Diaz-Gimeno and Juan A Garcia-Velasco
Effects of superovulation on the endometrium / Natalie Hannan and Jemma Evans
Screening the uterine microbiome prior to embryo transfer / Inmaculada Moreno and Carlos Simon
Estrogen and progesterone support in ART : optimizing implantation / Jamie Stanhiser and Steven L. Young
The role of hysteroscopy and endometrial scratch in improving endometrial receptivity / Yuval Or and Zeev Shoham
Fibroids and polyps : their effect on implantation / Beverley Vollenhoven and Sarah Hunt
Cleavage stage or blastocyst transfer : which is better? / Jason Kasraie
Dummy embryo transfer / Khaldoun Sharif and Gamal I Serour
Does the type of catheter used for embryo transfer matter? / Tia Hunjan, Shirin Khanjani and Stuart Lavery
Should all embryos be transferred in unstimulated cycles? / Nikoletta Panagiotopoulou and Siladitya Bhattacharya
Rest after embryo transfer is unhelpful / Giuseppe Botta and Gedis Grudzinska
Ectopic pregnancies : why do they happen? / R.R. Chodankar and Andrew Horne
The role on NK cells in implantation after IVF and treatment strategies / Norman Shreeve and Ashley Moffett
Sex and immune receptivity for embryo transfer / David J. Sharkey and Sarah A. Robertson
Immunotherapy/IVIG, prednisolone and intralipid in IVF / Ole Bjarne Christiansen and Kathinka Marie Nyborg
The role of heparin and aspirin to aid implantation / Luciano Nardo and Tarique Salman
Early pregnancy loss : causes and prevention / Shreeya Tewary and Jan J. Brosens
Is the endometrium in women with PCOS compromised? / Terhi T. Piltonen.

Summary: This book addresses the common criticisms of evidence-based healthcare, dispelling many of its myths and misconceptions, while providing a pragmatic framework for testing the validity of healthcare literature. It also helps readers to understand the central principles of evidence-based medicine, critically evaluate published data, and implement the results in practical settings. The readers are guided through each fundamental step of inquiry, from searching the literature, to assessing methodological quality, and appraising statistics. -- Publisher description

Contents:
Why read papers at all?
Searching the literature
Getting your bearings : what is this paper about?
Assessing methodological quality
Statistics for the non-statistician
Papers that report trials of drugs and other simple interventions
Papers that report trials of complex interventions
Papers that report diagnostic or screening tests
Papers that summarise other papers (systematic reviews and meta-analyses)
Papers that tell you what to do (guidelines)
Papers that tell you what things cost (economic analyses)
Papers that go beyond numbers (qualitative research)
Papers that report questionnaire research
Papers that report quality improvement case studies
Papers that describe genetic association studies
Applying evidence with patients
Criticisms of evidence-based healthcare.

Summary: "Easy to read and comprehensive. This book offers real practical guidance."'Matthew Walker, PhD, bestselling author of Why We Sleep Sleep difficulties affect millions of people'and the problem is getting worse. The deluge of sleep advice out there, referred to collectively as "sleep hygiene" rules, consists mostly of isolated recommendations for things not to do, such as: Don't drink coffee close to bedtime. Don't watch TV in bed. Despite the popularity of these old rules, Dr. Rafael Pelayo tells us, sleep hygiene alone is rarely effective in helping people with serious sleep problems. We need new rules that reflect the growth of knowledge in sleep science and can effectively improve our health. Pelayo's approach is to first take a step back and teach us how sleep works. He explains that nobody sleeps through the night; that the need for sleep is biological, but the way we sleep is learned; how much sleep you actually need each night, and that you can't get by with less. Then, once readers understand sleep and why it's so essential to our health and well-being, he offers a clear path to better sleep, with a flexible approach that will work for anyone. He offers a strategy for combatting jet lag: use your circadian rhythms to your advantage by maximizing your exposure to daylight. He advises you to think of napping like snacking: snacks are fine to tide you over during long stretches between meals, but if snacking too much or too late keeps you from eating dinner, it's a problem'same goes for naps and a good night's sleep! And he cautions that alcohol is a double-edged sword: it may help you fall asleep, but it also disrupts your sleep cycle. The information in this friendly, accessible book will help readers sleep better, wake up refreshed, and have a healthier life.

Summary: "Sleep difficulties affect millions of people-and the problem is getting worse. The deluge of sleep advice out there, referred to collectively as "sleep hygiene" rules, consists mostly of isolated recommendations for things not to do, such as: Don't drink coffee close to bedtime. Don't watch TV in bed. Despite the popularity of these old rules, Dr. Rafael Pelayo tells us, sleep hygiene alone is rarely effective in helping people with serious sleep problems. We need new rules that reflect the growth of knowledge in sleep science and can effectively improve our health. Pelayo's approach is to first take a step back and teach us how sleep works. He explains that nobody sleeps through the night; that the need for sleep is biological, but the way we sleep is learned; how much sleep you actually need each night, and that you can't get by with less. Then, once readers understand sleep and why it's so essential to our health and well-being, he offers a clear path to better sleep, with a flexible approach that will work for anyone. He offers a strategy for combatting jet lag: use your circadian rhythms to your advantage by maximizing your exposure to daylight. He advises you to think of napping like snacking: snacks are fine to tide you over during long stretches between meals, but if snacking too much or too late keeps you from eating dinner, it's a problem-same goes for naps and a good night's sleep! And he cautions that alcohol is a double-edged sword: it may help you fall asleep, but it also disrupts your sleep cycle. The information in this friendly, accessible book will help readers sleep better, wake up refreshed, and have a healthier life"-- Provided by publisher.

Contents:
How sleep works
Snoring? start here
Sleep for the insomniac
A day in the (night) life
Sleep disorders
A lifetime of sleeping well
Dreaming: the theater of the night
Seeing a sleep doctor.

Contents:
Creating an effective learning environment
Teaching in clinical contexts
Workplace-based assessment and feedback
Common problems in clinical teaching
Next steps.

Summary: "All academics need to write, and many struggle to finish their dissertations, articles, books, or grant proposals. Writing is hard work and can be difficult to wedge into a frenetic academic schedule. This revised and updated edition of Paul Silvia's popular guide provides practical, lighthearted advice to help academics overcome common barriers and become productive writers. Silvia's expert tips have been updated to apply to a wide variety of disciplines, and this edition has a new chapter devoted to grant and fellowship writing"-- Provided by publisher.

Contents:
Introduction
Specious barriers to writing a lot
The care and feeding of writing schedules
Starting a writing group
A brief foray into style
Writing journal articles
Writing books
Writing proposals for grants and fellowships
"The good things still to be written."

Summary: "This newly updated version of the classic guide to writing and publishing scientific papers provides the tools needed to succeed in the communication aspects of a scientific career"--Provided by publisher. "Now thoroughly updated and expanded, this new edition of a classic guide offers practical advice on preparing and publishing journal articles as well as succeeding in other communication-related aspects of a scientific career. Provides practical, easy-to-read, and immediately applicable guidance on preparing each part of a scientific paper: from the title and abstract, through each section of the main text, to the acknowledgments and references. Explains step by step how to decide to which journal to submit a paper, what happens to a paper after submission, and how to work effectively with a journal throughout the publication process. Includes key advice on other communication important to success in scientific careers, such as giving presentations and writing proposals. Presents an insightful insider's view of how journals actually work--and describes how best to work with them."--Publisher's description.

Contents:
Part I: Some preliminaries. What is scientific writing? ; Historical perspectives ; Approaching a writing project ; What is a scientific paper? ; Ethics in scientific publishing ; Where to submit your manuscript
Part II: Preparing the text. How to prepare the title ; How to list the authors and addresses ; How to prepare the abstract ; How to write the introduction ; How to write the materials and methods section ; How to write the results ; How to write the discussion ; How to state the acknowledgments ; How to cite the references
Part III: Preparing the tables and figures. How to design effective tables ; How to prepare effective graphs ; How to prepare effective photographs
Part IV: Publishing the paper. Rights and permissions ; How to submit the manuscript ; The review process (how to deal with editors) ; The publishing process (how to deal with proofs) and after publication
Part V: Doing other writing for publication. How to write a review paper ; How to write opinion (letters to the editor, editorials, and book reviews) ; How to write a book chapter or a book ; How to write for the public ; How to present a paper orally ; How to prepare a poster ; How to write a conference report
Part VII: Scientific style. Use and misuse of English ; Avoiding jargon ; How and when to use abbreviations ; Writing clearly across cultures and media ; How to write science in English as a foreign language
Part VIII: Other topics in scientific communication. How to write a thesis ; How to prepare a curriculum vitae, cover letter, and personal statement ; How to prepare grant proposals and progress reports ; How to write a recommendation letter : and how to ask for one ; How to work with the media ; How to provide peer review ; How to edit your own work ; How to seek a scientific-communication career
Appendix 1: Selected journal title word abbreviations
Appendix 2: Words and expressions to avoid
Appendix 3: SI (Système International) prefixes and their abbreviations
Appendix 4: Some helpful websites
Glossary.

Summary: "'The purpose of scientific writing,' according to Barbara Gastel and Robert A. Day, 'is to communicate new scientific findings. Science is simply too important to be communicated in anything other than words of certain meaning.' This clear, beautifully written, and often funny text is a must-have for anyone who needs to communicate scientific information, whether they're writing for a professor, other scientists, or the general public. The thoughtfully revised ninth edition retains the most important material-including preparing text and graphics, publishing papers and other types of writing, and plenty of information on writing style-while adding up-to-date advice on copyright, presenting online, identifying authors, creating visual abstracts, and writing in English as a non-native language.A set of valuable appendixes provide ready reference, including words and expressions to avoid, SI prefixes, a list of helpful websites, and a glossary. Students and working scientists will want to keep How to Write and Publish a Scientific Paper at their desks and refer to it at every stage of writing and publication."-- Back cover.

Summary: This book guides medical researchers through all stages of transforming their data and ideas into a published paper. Many researchers in medicine struggle to get their research written and published. One reason for this is that most medical researchers have not received much instruction in the subjects needed to write and publish scientific papers: research methodology, ethics, statistics, data visualization, writing, revising, and the practicalities of publishing. This book tackles all the major scientific issues that routinely lead to manuscripts getting rejected from the journals. The section "Preparing" covers the range of methodological, ethical, and practical aspects that researchers need to address before starting to write their paper. The section "Analyzing" reviews commonplace problems in the statistical analysis and presentation, and how to resolve those problems. The section "Drafting" describes what to write in the various parts of a paper (the Introduction, Methods, Results, Discussion, Abstract, etc.). The section "Revising" explains and illustrates how to improve the writing style of any manuscript. The section "Publishing" discusses how to navigate the peer review process and all other practical aspects of the publishing phase. The entire book draws on the author's decade of experience as an independent medical writer and research consultant. More importantly, the book is grounded in the existing scientific and scholarly literature, with extensive references and an annotated bibliography. After reading this book, medical researchers will know how to write better quality medical papers, so they can publish their work in better journals with less time and struggle.

Summary: The Combahee River Collective, a group of radical black feminists, was one of the most important organizations to develop out of the anti-racist and women's liberation movements of the 1960s and 70s. In this collection, founding members of the organization and contemporary activists reflect on the legacy of its contributions to black feminism and its impact on today's struggles. "In the last several years, Black feminism has reemerged as the analytical framework for the activist response to the oppression of trans women of color, the fight for reproductive rights, and, of course, the movement against police abuse and violence. The most visible organizations and activists connected to the Black Lives Matter movement speak openly about how Black feminism shapes their politics and strategies today. The interviews I have compiled in this book -- with the three authors of the Combahee River Collective Statement, Barbara Smith, Beverly Smith, and Demita Frazier, #BlackLivesMatter cofounder Alicia Garza, and historian and activist Barbara Ransby -- are an attempt to show how these politics remain historically vibrant and relevant to the struggles of today. As Demita Frazier says, the point of talking about Combahee is not to be nostalgic; rather, we talk about it because Black women are still not free." -- Keeanga-Yamahtta Taylor, from the introduction.

Contents:
Introduction
The Combahee River Collective statement
Barbara Smith
Beverly Smith
Demita Frazier
Alicia Garza
Comments by Barbara Ransby
Acknowledgments
Contributor biographies.

Contents:
Discovery and classification of homeobox genes in animal genomes / Ferdinand Marlétaz, Jordi Paps, Ignacio Maeso, and Peter W. H. Holland
How to study hox gene expression and function in mammalian oocytes and early embryos / Delphine Paul, Caroline Sauvegarde, René Rezsohazy, and Isabelle Donnay
Genetic lineage tracing analysis of anterior hox expressing cells / Brigitte Laforest, Nicolas Bertrand, and Stéphane Zaffran
A genetic strategy to obtain P-Gal4 elements in the Drosophila hox genes / Luis de Navas, David Foronda, Delia del Saz, and Ernesto Sánchez-Herrero
Hox complex analysis through BAC recombineering / Mark Parrish, Youngwook Ahn, Christof Nolte, Bony De Kumar and Robb Krumlauf
The genetics of murine Hox loci : TAMERE, STRING, and PANTHERE to engineer chromosome variants / Patrick Tschopp and Denis Duboule
Topological organization of Drosophila hox genes using DNA fluorescent in situ hybridization / Frédéric Bantignies and Giacomo Cavalli
Mining the Cis-regulatory elements of hox clusters / Navneet Kaur Matharu and Rakesh K. Mishra
Functional analysis of hox genes in Zebrafish / Franck Ladam and Charles G. Sagerström
Transgenesis in non-model organisms : the case of Parhyale / Zacharias Kontarakis and Anastasios Pavlopoulos
Tissue specific RNA isolation in Drosophila embryos : a strategy to analyze context dependent transcriptome landscapes using FACS / Arnaud Defaye and Laurent Perrin
Hox transcriptomics in Drosophila embryos / Maria Polychronidou and Ingrid Lohmann
Measuring hox-DNA binding by electrophoretic mobility / Kelly Churion [and four others]
Chromatin immunoprecipitation and chromatin immunoprecipitation with massively parallel sequencing on mouse embryonic tissue / Shilu Amin and Nicoletta Bobola
chIP for hox proteins from Drosophila imaginal discs / Pavan Agrawal and L. S. Shashidhara
SELEX-seq : a method for characterizing the compete repertoire of binding site preferences for transcription factor complexes / Todd R. Riley [and six others]
DamID as an approach to studyinhg long-distance chromatin iteractions / Fabienne Cléard, François Karch, and oRbert K. Maeda
cgCHIP : a cell type- and gene-specific method for chromatin analysis / Marios Agelopoulos, Daniel J. McKay, and Ricahrd S. Mann
Bimolecular fluorescence complementation (biFC) in live Drosophila embryos / Marilyne Duffraisse, Bruno Hudry, and Samir Merabet
Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia / Laura M. Kettyle, Fabio G. Liberante, and Alexander Thompson.

Contents:
Anatomical sites and subsites of head and neck cancer
Epidemiology of oral HPV infection and HPV-associated head and neck cancer
Frequent behavioural questions with an HPV-positive malignancy of the head and neck
The molecular biology of HPV-related head and neck cancer
The diagnosis of HPV-related head and neck squamous cell carcinoma: Recognition of its microscopic appearance and the use of ancillary detection assays
Clinical management of HPV-related oropharyngeal cancer
The role of vaccines for HPV-related head and neck cancers
The care of the HPV-negative head and neck cancer patient: Presentation, prognosis, treatment. .

Contents:
Epidemiology and molecular biology of HPV positive HNSCC
HPV testing
Non-surgical treatment of HPV positive tumours
Surgical treatment of HPV Positive tumours
Predictive factors for outcome and quality of life in HPV positive and HPV negative
HPV
prevention vaccination, ongoing trials.

Summary: Protein homeostasis, or "Proteostasis", lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.

Contents:
Intro
Preface: Dedication to Susan Lindquist
Contents
Part I: Structure
1: Structural and Biochemical Properties of Hsp40/Hsp70 Chaperone System
1.1 Hsp70 Chaperone System
1.1.1 Hsp70 Domain Structure and Functional Cycle
1.1.2 Substrate Recognition and Remodeling by the Hsp70 Chaperones
1.2 Regulation of Hsp70 Function by Co-chaperones
1.2.1 J-Domain Proteins
1.2.2 Nucleotide Exchange Factors
1.2.2.1 Nucleotide Cycle Regulation Beyond JDPs and NEFs
1.3 Hsp70s Interaction with Other Cellular Chaperone Systems 1.3.1 Hsp70 Chaperones in Protein Disaggregation
1.4 Conclusion and Perspectives
References
2: The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation
2.1 Introduction
2.2 The Structure of CCT
2.3 CCT Substrates and Specificity
2.4 Conformational Changes and Nucleotide Hydrolysis
2.5 CCT and Cancer
2.6 CCT as Key Regulator of Cell Cycle
2.7 Is CCT a Possible Antiproliferation Target?
References
3: Regulation of Hsf1 and the Heat Shock Response
3.1 Introduction: The HSR in Health and Disease 3.2 Defining the Transcriptional Response to Heat Shock
3.3 What Activates the HSR?
3.4 Hsp70 and Hsf1 Constitute a Negative Feedback Loop That Controls the HSR
3.5 Hsp90 Negatively Regulates Hsf1 Orthogonally to Hsp70
3.6 Phosphorylation Is Dispensable for Hsf1 Activity During Heat Shock
3.7 Coordination of the HSR Across Tissues
3.8 Conclusion
References
Part II: Function
4: Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease
4.1 Introduction 5: The Multifaceted Role of HSF1 in Tumorigenesis
5.1 Introduction
5.2 HSF1 Structure and Function
5.2.1 HSF1 Regulation by Post Translational Modification
5.3 HSF1 in Carcinogenesis
5.4 How Is HSF1 Activated in Cancer?
5.5 How Does HSF1 Support the Malignant State in Cancer?
5.5.1 HSF1 Regulation of Cancer Cell Proteostasis
5.5.2 HSF1 Regulation of mRNA Processing and Protein Synthesis
5.5.3 HSF1 Regulation of DNA Repair
5.5.4 HSF1 Regulation of Energy Metabolism
5.5.5 HSF1 Regulation of Cell Motility, Migration and Adhesion

Contents:
1. Sticky blood: the disease is common
2. Main clinical features
3. Clotting in veins
4. Stroke
5. Memory loss and "Alzheimers"
6. Headaches, migraine and fits
7. The spinal cord and "multiple sclerosis"
8. The heart and arteries
9. Other organs
10. The "catastrophic" antiphospholipid syndrome
11. Pregnancy and fetal loss
12. Hughes' syndrome and lupus
13. Treatment
14. The outlook
15. What blood tests do we use?
16. Research
17. Background
18. An update
19. Further reading and websites
Index.

Contents:

v. 1. Symptomatology.

Summary: The book explores various aspects of hydatid disease, including the background, parasitology, epidemiology, etiology, pathogenesis and presentation in humans. It features dedicated chapters on hydatidosis of liver, spleen, peritoneum, kidney, pelvis, and disseminated hydatid disease, and also provides detailed information on the latest surgical and non-surgical methods for treating the condition, such as drug therapy and laproscopic management. The book is primarily intended for undergraduate and postgraduate students of surgery and medicine, but is also useful to veterinary science students and pharmaceutical companies. Further, it serves as a valuable reference resource for academics and researchers in associated fields.

Contents:
Biology of the Echinococcus
Hydatid disease of the liver : clinical presentation and complications
Diagnosis of hydatid disease of the liver
Surgical management of hydatid liver disease
Drug therapy in hydatid disease of the liver
Alveolar hydatid disease
Primary splenic hydatidosis
Hydatid disease of the kidney
Primary extrahepatic abdominal hydatidosis
Minimally invasive management of hepatic hydatidosis.

Summary: Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex -- the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture. Herculano-Houzel shows us how she came to these conclusions -- making "brain soup" to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. --Publisher's description.

Contents:
Preface
Humans rule!
Brain soup
Got brains?
Not all brains are made the same
Remarkable but not extraordinary
The elephant in the room
What cortical expansion?
A body matter?
So how much does it cost?
Brains or brawn : you can't have both
Thank cooking for your neurons
... But plenty of neurons are not enough
Epilogue : our place in nature
Appendix A: Body mass, brain mass, and number of neurons
Appendix B: Scaling rules.

Contents:
Basic anatomical concepts
Thorax
Upper limbs
Abdomen
Pelvis and perineum
Lower limbs
Head and neck.

Contents:
Organ systems and tissues
The cell
Introductory discussion on water, pH, buffers, and general features of receptors, channels, and pumps
Proteins
Enzymes
Insulin and sugars
Glycogen and glycogenolysis
Glycolysis and gluconeogenesis
Lipids
Nucleic acids and molecular genetics
Protein biosynthesis
Transcription
Metabolism of amino acids
Metabolism of fat, carbohydrate, and nucleic acids
Polypeptide hormones
Steroid hormones
Growth factors and cytokines
Membrane transport
Micronutrients (metals and iodine)
Vitamins and nutrition
Blood and lymphatic system
Appendix 1: Abbreviations of the common amino acids
Appendix 2: The genetic code
Appendix 3: Weights and measures
Appendix 4: Answer key for chapter questions.

Contents:
1. Introduction to human bond communication
2. General concepts behind human bond communication
3. Advanced reconfigurable 5G architectures for human bond communication
4. Data mining of the human being
5. Human-centric IoT networks
6. Body as a network node: key is the oral cavity
7. Human bond communication using cognitive radio approach for efficient spectrum utilization
8. Technology advancement and integration in the context of wildlife conservation
9. An investigation of security and privacy for human bond communication
10. The Internet of Everything and beyond: the interplay between things and humans
11. Human bond communications in health: ethical and legal issues
12. Human bond communication: a new and unexplored frontier for intellectual property and Information and Communciation Technology law
13. Predicting the future of ICT: a historical perspective
14. Human bond communication beyond 2050
Index.

Contents:
Intro; Preface; Acknowledgments; Contents; Part I: Mechanisms of Tumor Progression; Mechanisms Underlying Metastatic Pancreatic Cancer; PDAC Metastasis and Outcomes; Models of Metastasis; Genetically Engineered Mouse Models of Metastatic PDAC; Orthotopic Models of Pancreatic Cancer Metastasis; Mechanisms of Metastasis; EMT-MET Axis and Cellular Plasticity; Metastatic Organotropism: The Role of Exosomes and EMT Modulators; Epigenetic and Post-Transcriptional Regulators of EMT and Metastasis; Concluding Remarks; References; Current Perspectives on Nasopharyngeal Carcinoma; Introduction Historic PerspectiveCurrent Perspectives; Epidemiology; Incidence Rate; Impact of Human Migration on NPC Incidents; Risk Factors; Epstein Barr Virus (EBV); Single Nucleotide Polymorphisms (SNPs); Intake of Certain Foods; Model System for Investigating Nasopharyngeal Carcinoma; Potential Use of Zebrafish for Modeling Human NPC; Immunotherapy for Nasopharyngeal Carcinoma; Immunotherapy: General Concepts; Relevant Cancer Mouse Models for Preclinical Investigation of Immunotherapy; Immunotherapeutic Approaches for Cancer Treatment; Immunotherapy in NPC; Concluding Remarks; References An In Vitro Model of Triple-Negative Breast Cancer17€-Estradiol Induces Transformation and Tumorigenesis in Human Breast Epithelial Cells; Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17-Beta-Estradiol; Developing a Unique Model of Triple Negative Breast Cancer; Chromatin Remodeling During Human Breast Epithelial Cell Transformation; Concluding Remarks; References; Emerging Role of Novel Biomarkers of Ly6 Gene Family in Pan Cancer; Introduction; Expression of Ly6D, E, H, and K Genes in Normal Tissues; Ly6D; Ly6E; Ly6H; Ly6K Expression of Ly6D, E, H, and K Genes in Tumor TissuesLy6D; Ly6E; Ly6H; Ly6K; Mechanisms Associated Ly6D, E, H, and K Gene Family; Ly6D; Ly6E; Ly6H; Ly6K; Summary; References; The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy; Isolation of Gankyrin from Hepatocellular Carcinoma; Enhanced Degradation of RB (Retinoblastoma-Associated Protein) and p53 (Cellular Tumor Antigen p53) by Gankyrin; Gankyrin as a Killer of Multiple Tumor Suppressor Proteins; Animal Models Overexpressing Gankyrin in the Liver Importance of Non-Parenchymal Cells in Carcinogenesis as Demonstrated by Gankyrin-Knockout MiceGankyrin as a Promising Therapeutic Target; Experimental Anti-Gankyrin Agents; Conclusion; References; Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis; Introduction; Updated Mechanisms of Ethanol-Mediated Carcinogenesis; Contributing Roles of CYP2E1 and Other P450 Isoforms in Tissue Injury and Cancer Development; Multiple Regulations of CYP2E1 and Alcohol-Related Tissue Injury and Carcinogenesis Distribution of CYP2E1 and Carcinogenesis in Extra-Hepatic Tissues

Summary: Telepatients using connected objects to collect time-sensitive data about their health are not neutral carriers of diagnosable symptoms. Patients are persons, or personal beings as well as co-carers, whose personal experience, history and know-how must be acknowledged in time-sensitive telecare practices. Such practices require a relational ethics, inspired by medical ethics and an ethics of virtues, focusing on vulnerability and emotional health, to oversee telecare good practices, define a new therapeutic alliance compliant with patients' values, and reconcile the technical and human sides of telemedicine.

Contents:
Part 1. The Person in the Age of Telecare ; 1. The Advent of Digital Healthcare ; 2. The Human Ethical Challenge
Part 2. Telecare Phenomenology ; 3. A Cross-Dimensional Look at the 'Patient Experience' ; 4. The Patient Experience Under Telemonitoring ; 5. The Person Standing the Test of Digital Clocks ; 6. Experiential knowledge of the 'Subject of Care
Part 3. Toward an Ethics of "Time-sensitive" Telecare ; 7. Subjectivising the Future: or the 'Patient Project' Temporality ; 8. 'Chrono-Sensitivity': From Concepts to Ethics.

Summary: This book constitutes the end result of 20 years-long effort that goes beyond a Psychiatrists standard clinical training and education, even that of a Psychiatrist that follows an academic career. Trying to explain how the human mind works is hard and the heterogeneity of the audience make the attempt even more difficult. There is a conceptual difference between the words brain and mindand this makes the effort even more difficult since the present book tries to preserve the strict scientific approach concerning all the topics discussed. The work elaborates and tries to answer questions frequently phrased by audiences in teaching classes and in conferences and does not avoid any question. In order to achieve this goal, it is structured in chapters all the way from the molecule and the cell to consciousness and free will. The book targets mainly the mental health care professionals as an audience, and to a lesser extend the other health professionals. It is written according to the authors view concerning the training and educational needs of Psychiatrists and Psychologists and to a lesser degree of Neurologists and Neuroscientists in general.

Contents:
Introductory remarks
Macroscopic structure of the brain
Microscopic structure of the brain
The cell membrane
Neurotransmitters. The synapse
Function of neurotransmitter systems
Second messengers
Neurotrophic factors
Functional organization of the brain
Higher cognitive function
Thought and intelligence
Mood
Sleep
Consciousness and free will
Temperament and personality
Sex differences
Brain genetics
Sociobiology.

Contents:
History of the molecular biology of cytomegaloviruses / Mark F. Stinski
Overview of human cytomegalovirus pathogenesis / Maciej T. Nogalski, Donna Collins-McMillen, and Andrew D. Yurochko
Distinct properties of human cytomegalovirus strains and the appropriate choice of strains for particular studies / Giada Frascaroli and Christian Sinzger
Use of diploid human fibroblasts as a model system to culture, grow, and study human cytomegalovirus infection / Elizabeth A. Fortunato
Use of recombinant approaches to construct human cytomegalovirus mutants / Iryna Dekhtiarenko, Luka éCiécin-éSain, and Martin Messerle
Use of primary human cells (fibroblasts, monocytes, and others) to assess human cytomegalovirus function / Emma Poole, Matthew Reeves, and John H. Sinclair
Hematopoietic long-term culture (hLTC) for human cytomegalovirus latency and reactivation / Mahadevaiah Umashankar and Felicia Goodrum
Analysis of cytomegalovirus binding/entry-mediated events / Gary C.T. Chan and Andrew D. Yurochko
Use of 5-Ethynyl-2' -deoxyuridine labelling and flow cytometry to study cell cycle-dependent regulation of human cytomegalovirus gene expression / Lèuder Wiebusch and Christian Hagemeier
Methods for studying the function of cytomegalovirus GPCRs / Christine M. O'Connor and William E. Miller
Methods for the detection of cytomegalovirus in glioblastoma cells and tissues / Charles S. Cobbs, Lisa Matlaf, and Lualhati E. Harkins
Methods to study the nucleocytoplasmic transport of macromolecules with respect to their impact on the regulation of human cytomegalovirus gene expression / Marco Thomas ... [et al.]
Fluorescence-based laser capture microscopy technology facilitates identification of critical in vivo cytomegalovirus transcriptional programs / Craig N. Kreklywich ... [et al.]
Techniques for characterizing cytomegalovirus-encoded miRNAs / Lauren M. Hook ... [et al.]
What we have learned from animal models of HCMV / Pranay Dogra and Tim E. Sparer
Rodent models of congenital cytomegalovirus infection / Djurdjica Cekinovic, Vanda Juranic Lisnic, and Stipan Jonjic
Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccines / Suresh B. Boppana and William J. Britt
Approaches for the generation of new anti-cytomegalovirus agents : identification of protein-protein interaction inhibitors and compounds against the HCMV IE2 protein / Beatrice Mercorelli ... [et al.].

Summary: This book discusses the findings of research on the human dimensions of wildlife management conducted in Japan, demonstrating how such research and approaches have contributed to mitigating human-wildlife conflicts. Human-wildlife conflicts, including agricultural and property damage as well as occasional casualties, are a global problem for which local residents, managers, and stakeholders around the world are struggling to find solutions. Human dimensions of wildlife management (HDW) is an academic field developed in North America in the 1970s to gather information on the social aspects of human-wildlife issues to help wildlife managers and stakeholders implement effective decision-making measures. However, HDW is not widely recognized or applied outside North America, and few studies have investigated whether HDW approaches would be effective in different cultural settings. This is the first book written in English to introduce the HDW theories and practices implemented in Asia. Presenting innovative approaches and research techniques, as well as tips on how to introduce HDW methods into culturally different societies, it is a valuable resource not only for researchers and students in this field, but also for government officials/managers, NGOs, residents and other stakeholders who are affected by human-wildlife conflicts around the globe.

Contents:
Introduction : new perspectives of wildlife management
What is "human dimensions"?
Wildlife management in Japan
Studies on the human dimension of black bear management in Japan
Human dimensions studies on programs for reducing human-wildlife conflicts in Tochigi Prefecture, Japan
Introducing ideas and approaches of human dimensions in Japan
Educating international students about the human dimensions of wildlife management.

Summary: This concise work on embryo transfer is yet another contribution to the persevering effort to disseminate latest information on the science and skill of performing a traumatic and successful embryo transfer. It is the most critical culmination of the assisted reproductive technology (ART) stimulation cycle, and a rate-limiting step in dictating the success of treatment. The well-worded chapters draw the reader's attention to significant aspects before initiating the actual embryo transfer, such as possible causes of failure at the embryo transfer stage, uterine evaluation, mock embryo transfer (ET), experience of the physician, and the use of ultrasound-guidance to monitor ET. The protocol for difficult transfers, variables that affect the success of ET, and the influence of the catheter used for ET have also been dealt with. The unique feature of this book is its pragmatic approach that can translate into solutions to the numerous frustrating ART failures that more often than not, may be attributed to an inefficient ET procedure. It helps the reader understand the integrity of embryo transfer, unravel its obvious simplicity and bridge the success between the several steps of ART. By highlighting the impeding problems associated with ET procedure and providing valid, scientific solutions, this stimulating edition will help the readers improve the ART success rates in their clinical practice. .

Contents:
Evaluation of the uterus prior to embryo transfer.-Trial Embryo Transfer (Mock Transfer)
Does the Experience of the Provider Affect Pregnancy Rates After Embryo Transfer?
Ultrasound-Guided ETs or Clinical Touch ETs?
Variables That Affect a Successful Embryo Transfer
Management of Difficult Embryo Transfers
Facts and Myths of Embryo Transfer .-Uterine Contractility and Embryo Transfer.- Embryo Transfer Media and Catheters
Is There A Role for Tubal Transfers?
Loading and Expulsion of Embryos.

Summary: "Bruce Carlson's Human Embryology and Developmental Biology is one of the most detailed texts available for those who want to truly understand both the morphological and molecular aspects of human embryological development. Fully updated in its seventh edition, the book provides a thorough grounding in all aspects of embryology. It presents in detail the molecular and cellular basis for embryological processes, from early development through to development of body systems. It covers examples of congenital malformations and their underlying mechanisms, and comes complete with clinical vignettes and review questions to support learning. This book will suit medical and science students taking embryology courses as well as scientists and clinicians who find themselves returning to this topic throughout their careers"-- Provided by publisher.

Contents:
Getting Ready for Pregnancy
Transport of Gametes and Fertilization
Molecular Basis for Embryonic Development
Cleavage and Implantation
Formation of Germ Layers and Early Derivatives
Establishment of the Basic Embryonic Body Plan
Placenta and Extraembryonic Membranes
Developmental Disorders: Causes, Mechanisms, and Patterns
Integumentary, Skeletal, and Muscular Systems
Limb Development
Nervous System
Neural Crest
Sense Organs
Head and Neck
Digestive and Respiratory Systems and Body Cavities
Urogenital System
Cardiovascular System
Fetal Period and Birth.

Summary: Master the concepts you need to know with Human Embryology and Developmental Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow "road map" through the most up-to-date scientific knowledge, giving you a deeper understanding of the key information you need to know for your courses, exams, and ultimately clinical practice. Visualize normal and abnormal development with hundreds of superb clinical photos and embryological drawings.Access the fully searchable text online, view animations, answer self-assessment questions, and much more at www.studentconsult.com.

Contents:
Getting ready for pregnancy
Transport of gametes and fertilization
Cleavage and implantation
Molecular basis for embryonic development
Formation of germ layers and early derivatives
Establishment of the basic embryonic body plan
Placenta and extraembryonic membranes
Developmental disorders : causes, mechanisms, and patterns
Integumentary, skeletal, and muscular systems
Limb development
Nervous system
Neural crest
Sense organs
Head and neck
Digestive and respiratory systems and body cavities
Urogenital system
Cardiovascular system
Fetal period and birth.

Contents:
Derivation of human embryonic stem cell lines from vitrified human blastocysts / Cara K. Bradley ... [et al.] - Characterizing pluripotent stem sells using the TaqMan® hPSC scorecardTM panel / Jeffrey Fergus, Rene Quintanilla, and Uma Lakshmipathy
Growth of human pluripotent stem cells using functional human extracellular matrix / Andres Sanz-Garcia, Miodrag Stojkovic, and Carmen Escobedo-Lucea
Efficient expansion of dissociated human pluripotent stem cells using a synthetic substrate / Eihachiro Kawase
Microarray approach to identify the signaling network responsible for self-renewal of human embryonic stem cells / Noboru Sato and Ali Brivanlou
Monitoring stemness in long-term hESC sultures by real-time PCR / Amparo Galan and Carlos Simon
Study of gap junctions in human embryonic stem cells / Alice Pebay and Raymond C.B. Wong
Immunofluorescence microscopy and mRNA analysis of human embryonic stem cells (hESCs) including primary cilia associated signaling pathways / Maj Linea Vestergaard ... [et al.]
Analysis of intracellular calcium signaling in human embryonic stem cells / Adrienn Pentek, Katalin Paszty, and Agota Apati
Genetic manipulation of human embryonic stem cells / Rachel Eiges
Genetic modification in human pluripotent stem cells by homologous recombination and CRISPR/Cas9 system / Haipeng Xue ... [et al.]
Use of multicolor flow cytometry for isolation of specific cell populations deriving from differentiated human embryonic stem cells / Isabella Mengarelli, Andrew Fryga, and Tiziano Barberi
Definitive endoderm differentiation of human embryonic stem cells combined with selective elimination of undifferentiated cells by methionine deprivation / Tomonori Tsuyama, Nobuaki Shiraki, and Shoen Kume
Derivation of endothelial cells and pericytes from human pluripotent stem cells / Sravanti Kusuma and Sharon Gerecht
Differentiation of human embryonic stem cells on periodontal ligament fibroblasts / Y. Murat Elcin, Bulend Inanc, and A. Eser Elcin
Derivation of epithelial cells from human embryonic stem cells as an in vitro model of vocal mucosa / Vlasta Lungova, Ciara Leydon, and Susan Thibeault
Human embryonic and hepatic stem cell differentiation visualized in two and three dimensions based on serial sections / Peter S. Vestentoft ... [et al.]
Derivation of chondrogenic cells from human embryonic stem cells for cartilage tissue engineering / Wei Seong Toh and Tong Cao
Microgrooved surface modulates neuron differentiation in human embryonic stem cells / David Lu ... [et al.]
Directed differentiation of human embryonic stem cells into neural progenitors / Erin Banda and Laura Grabel
Direct conversion of pluripotent human embryonic stem cells under defined culture conditions into human neuronal or cardiomyocyte cell therapy derivatives / Xuejun H. Parsons
Generation of epithelial cell populations from human pluripotent stem cells using a small-molecule inhibitor of Src family kinases / Joshua A. Selekman, Xiaojun Lian, and Sean P. Palecek
Dual-SMAD inhibition/WNT activation-based methods to induce neural crest and derivatives from human pluripotent stem cells / Stuart M. Chambers ... [et al.]
Accelerated three-dimensional neuroepithelium formation from human embryonic stem cells and its use for quantitative differentiation to human retinal pigment epithelium / Yu Zhu, Sven Schreiter, and Elly M. Tanaka
Efficient production of photoreceptor precursor cells from human embryonic stem cells / Anat Yanai ... [et al.]
Generation of megakaryocytes and platelets from human pluripotent stem cells / Marjorie Pick
Simple protocol for the generation of cardiomyocytes from human pluripotent stem cells / Glen Lester Sequiera, Ashish Mehta, and Winston Shim
Erratum to: Microgrooved surface modulates neuron differentiation in human embryonic stem cells / David Lu ... [et al.].

Summary: The view "Its all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendels experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer. This book provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells forming our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook "Human Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Contents:
Introduction
Chromatin and gene expression
DNA methylation
Histone modifications
Chromatin modifying proteins and RNAs
Embryogenesis and cellular differentiation
Population epigenetics and aging
Cancer epigenetics
Neuroepigenetics
Nutritional epigenetics
Epigenetics of immune function
Epigenome-environment interactions and their therapy.

Summary: The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule "a picture tells more than thousand words". The content of the book is based on the lecture course "Molecular Medicine and Genetics" that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks "Mechanisms of Gene Regulation" (ISBN 978-94-017-7741-4) and "Nutrigenomics" (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine.

Contents:
What is epigenomics?
Methods and applications of epigenomics
The structure of chromatin
DNA methylation
The histone code
Chromatin modifiers
Chromatin remodelers and organizers
Embryogenesis and cellular differentiation
Population epigenomics and aging
Cancer epigenomics
Neuroepigenetics
Epigenomics of immune function
Nutritional epigenomics.

Summary: This book delivers a comprehensive review of human factors principles as they relate to surgical care inside and outside of the operating theatre. It provides multi-dimensional human-centered insights from the viewpoint of academic surgeons and experts in human factors engineering to improve workflow, treatment time, and outcomes. To guide the reader, the book begins broadly with Human Factors Principles for Surgery then narrows to a discussion of surgical specialties and scenarios. Each chapter follows the following structure: (1) An overview of the topic at hand to provide a reference for readers; (2) a case study or story to illustrate the topic; (3) a discussion of the topic including human factors insights; (4) lessons learned, or personal "pearls" related to improving the specific system described. Written by experts in the field, Human Factors in Surgery: Enhancing Safety and Flow in Patient Care describes elements of the surgical system and highlights the lessons learned from systems engineering. It serves as a valuable resource for surgeons at any level in their training that wish to improve their practice.

Contents:
Intro
Foreword
Acknowledgments
About the Book
Contents
Editors and Contributors
About the Editors
Contributors
Part I: Introduction
1: Introduction to Human Factors in Surgery
Part II: Human Factors
2: Human Factors Principles of Surgery
What Is Human Factors?
A (Very) Brief History of Human Factors
What Is a System?
What Does This Mean for Surgery?
The Person
Teamwork/Communication
Tasks
Tools/Technologies
Physical Environment
Organizational Conditions
Human Factors Methods
Conclusion
References 3: The Person: Individual- and Team-Level Factors Contributing to Safe and Successful Surgery
Who is Involved in Surgery?
Case Study
Overview
Methods for Measuring and Optimizing Individual- and Team-Level Constructs
Individual-Level Constructs
Team-Level Constructs
Conclusion
References
4: Safe and Effective Use of Tools and Technology in the Operating Room
Inroduction
Case Study
Methods
Workflow Analysis
Ethnography Analysis
Future Technologies and Considerations
References
5: Work System Tasks: Blending Art and Science
The Task Example of Task-Specific Surgical Workload
Surgical Tasks
Surgical Task Factors and Task Implications
Human Factors Approach to the Task
Task Analysis
Workflow Analysis
Workload Measurement
Outcome Measures
References
6: Surgical Performance and the Working Environment
Case Studies
The Surgical Work Environment
The Built Environment
The Operating Room Layout
Ancillary Space and the OR Suite
Ventilation, Temperature, and Humidity
Visual Environment
Acoustic Environment
Human Factors Approaches
Summary
References 7: Organizational Influences and Surgical System Safety
What Role Does the Organization Play in Surgical Safety and Performance?
Applying the Concepts in Real Life
Organizational Influences
Resource Allocation
Operational Aspects
Organizational Culture
Tools and Techniques to Understand Organizational Influences
Using the Human Factors Analysis and Classification System as a Framework to Understand Organizational Influences on Surgery
The Categorization of Unsafe Acts
The Just Culture
Creating a Safe Error Reporting Environment Organizational Change and Persistence
Responding to the Wrong-Side Surgery
Conclusion
References
Part III: Broad Surgical Considerations
8: Human Factors in Perioperative Care
Introduction/Overview
Preoperative Considerations/Human Factors
Case
Intraop Emergencies/Incidents
Case
Postoperative Care
Case
References
9: Counting Backwards: Tracing the Effect of Human Factors in Anesthesiology
What Is Anesthesiology
Case Study
How Can We Improve Anesthesiology Using Human Factor Principles?
Physical Ergonomics
Cognitive Support
Communication

Contents:
General aspects of fertility and infertility / Mark A. Damario
Genetics of male fertility / Yi-Nan Lin and Martin M. Matzuk
Genetics of female infertility due to anomalies of the ovary and mullerian ducts / Joe Leigh Simpson
Gene polymorphisms in female reproduction / Livio Casarini and Manuela Simoni
Understanding the spermatozoon / Queenie V. Neri ... [et al.]
Derivation of human embryonic stem cells (hESC) / Nikica Zaninovic, Qiansheng Zhan, and Zev Rosenwaks
Endocrinology of the menstrual cycle / Robert L. Barbieri
Assisted reproductive techniques / Jack Yu Jen Huang and Zev Rosenwaks
Novel markers of male infertility / Michael Funaro and Darius A. Paduch
Luteal phase support in ART treatments / Yuval Or, Edi Vaisbuch, and Zeev Shoham
General principles of cryopreservation / Roger G. Gosden
In vitro maturation of immature human oocytes for clinical application / Ri-Cheng Chian and Yun-Xia Cao
GnRH antagonist-based protocols for in vitro fertilization / David Reichman and Zev Rosenwaks
Ovarian stimulation for IVF : mild approaches / O. Hamdine, F. J. Broekmans, and B. C. J. M. Fauser
IVF stimulation : protocols for poor responders / Owen K. Davis
Oocyte retrieval and quality evaluation / Lucinda Veeck Gosden
Sperm retrieval and quality evaluation / Peter J. Stahl, Peter N. Schlegel, and Marc Goldstein
Treatment of male infertility / Gianpiero D. Palermo, Justin Kocent, Devin Monahan, Queenie V. Neri, and Zev Rosenwaks
Techniques for slow cryopreservation of embryos / Lucinda Veeck Gosden
Cryopreservation of eggs / Zsolt Peter Nagy ... [et al.]
Ovarian tissue cryopreservation and transplantation : a realistic, effective technology for fertility preservation / Dror Meirow, Hila Raanani, and Hannah Biderman
Detection of monogenic disorders and chromosome aberrations by preimplantation genetic diagnosis / Kangpu Xu and David Reichman
Embryo culture and selection : morphological criteria / Aparna Hegde and Barry Behr
Embryo selection using metabolomics / D. Sakkas
Embryo transfer / Anate Aelion Brauer and Glenn Schattman
Safety of intracytoplasmic sperm injection / Gianpiero D. Palermo, Queenie V. Neri, and Zev Rosenwaks
Human germ cell differentiation from pluripotent embryonic stem cells and induced pluripotent stem cells / Jose V. Medrano, Carlos Simon, and Renee Reijo Pera.

Contents:
Part I. Introduction
Part II. Structural and functional fetal development up to second trimester
Part III. Gene and human fetal development up to second trimester
Part IV. Impact of stem cell on growth and development of human fetus
Part V. Fetal endocrine development up to second trimester
Part VI. Fetal immune development: up to second trimester
Part VII. Fetal hepatic development: up to second trimester
Part VIII. Fetal cardiovascular development: up to second trimester
Part IX. Fetal neurological development: up to second trimester and its implication in adult neurodegenerative diseases
Part X. Fetal neuropsychiatric development: up to second trimester
Part XI. Fetal nephrological development: up to second trimester
Part XII. Fetal haematological development
Part XIII. Pharmacological implication of fetal development: up to second trimester
Part XIV. Surgical implications of fetal development: up to second trimester
Part XV. Fetal growth and adult life implications
Part XVI. Understanding fetal growth from the perspective of alternative medicine
Part XVII. Miscellaneous
Part XVIII. Ethics and human fetal tissue research.

Summary: "Written specifically for undergraduate students, Human Health and the Climate Crisis examines the direct and indirect human health impacts of climate change while uniquely exploring climate justice - the equitable protection of all people from climate impacts and the participation of all people in climate-related decision-making regardless of race/ethnicity, class, national origin, indigenous status and gender. This comprehensive text balances appropriate technical content with sufficient contextual information about public health, epidemiology, and climate modeling for students to be able to comprehend the scientific literature on health impacts"-- Provided by publisher.

Summary: This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.

Contents:
Preface
Part I. Alphaherpesviruses
Chapter 1.The Role of Herpes Simplex Virus Glycoproteins in Mediating Cell Entry
Chapter 2. Virus assembly and egress of HSV
Chapter 3. Us3 protein kinase encoded by HSV: the precise function and mechanism on viral life cycle
Chapter 4. Oncolytic virotherapy by HSV
Chapter 5. Neurological disorders by human alphaherpesviruses
Chapter 6. Antiviral drugs against alphaherpesvirus
Chapter 7. Vaccine development for VZV
Part II. Betaherpesviruses
Chapter 8. Glycoproteins of HHV-6A and HHV-6B
Chapter 9. Betaherpesvirus virion assembly and egress
Chapter 10. Chromosomal Integration by Human Herpesviruses 6A and 6B
Chapter 11. Structural aspects of betaherpesvirus-encoded proteins
Chapter 12. Betaherpesvirus complications and management during stem cell transplantation
Chapter 13. Vaccine development for Cytomegalovirus
Part III. Gammaherpesviruses
Chapter 14. KSHV genome replication and maintenance in latency
Chapter 15. Signal transduction pathways associated with Kaposi's sarcoma-associated herpesvirus-related tumors
Chapter 16. Pathological features of Kaposi's sarcoma-associated herpesvirus infection
Chapter 17. EBV-encoded latent genes
Chapter 18. Encyclopedia of EBV-encoded lytic genes: an update
Chapter 19. Animal models of human gammaherpesvirus infections
Chapter 20. Gastritis-infection-cancer sequence of Epstein Barr virus-associated gastric cancer
Chapter 21. EBV in T/NK-cell tumorigenesis
Chapter 22. Vaccine development for Epstein-Barr Virus.

Summary: Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

Contents:
Basic Tissues
Lymphatic System
Cardiovascular System
Integumentary System
Digestive System I: Upper Alimentary Tract
Digestive System II: Lower Alimentary Tract
Digestive System III: Liver and Pancreas
Respiratory System
Urinary System
Male Reproductive System
Female Reproductive System
Endocrine System
Nervous System
Sensory Organs.

Summary: The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care. This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and research professionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus. The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology.

Contents:
Part I: Structure and Function of the Hypothalamus
Introduction to the Hypothalamus: Correlates from Animal Studies
Anatomy and Topography of the Hypothalamus
Neuroimaging of the Hypothalamus
Neurophysiology of the Hypothalamus
Neuroendocrinology of the Hypothalamic-Pituitary-Adrenal Axis
Part II: Pathobiology and Dysfunction of the Hypothalamus
Neuropsychiatric, Neurologic, and Neurobehavioral Syndromes of the Hypothalamus
Neurosurgical Aspects of Hypothalamic Disease
Hormone Excess Syndromes of the Hypothalamic-Pituitary-Adrenal Axis
Hormone Deficiency Syndromes of the Hypothalamic-Pituitary-Adrenal Axis
Hypothalamic Obesity and Wasting Syndromes
Hypothalamic Sleep Disorders
Genetic Syndromes of Hypothalamic Dysfunction
Neuroendocrine Tumors of the Hypothalamus
Non-endocrine Tumors of the Hypothalamus
Non-neoplastic Mass Lesions of the Hypothalamus
Rapid-onset Obesity with Hypothalamic Dysregulation, Hypoventilation, and Autonomic Dysregulation (ROHHAD) and ROHHAD Association Syndromes
Infectious and Inflammatory Hypothalamic Diseases
Traumatic and Degenerative Hypothalamic Diseases
Iatrogenic Hypothalamic Diseases
Idiopathic Diseases of the Hypothalamus.

Contents:
1. Introduction: The anterior hypothalamus
2. History of hypothalamic research: "The spring of primitive existence"
3. Anatomy and cytoarchitectonics of the human hypothalamus
4. Morphology and distribution of hypothalamic peptidergic systems
5. MRI maps, segregation, and white matter connectivity of the human hypothalamus in health
6. Magnetic resonance imaging of the hypothalamo-pituitary region
7. Resting-state functional connectivity of the human hypothalamus
8. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology-- 9. Matching of the postmortem hypothalamus from patients and controls
10. Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration
11. The diagonal band of Broca in health and disease
12. Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease
13. Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease
14. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease
15. The circadian system: From clocks to physiology
16. Development of the circadian system and relevance of periodic signals for neonatal development
17. Disrupted circadian rhythms and mental health
18. Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease
19. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities
20. The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
21. Retina and melanopsin neurons
22. Melatonin and the circadian system: Keys for health with a focus on sleep
23. Melatonin receptors, brain functions, and therapies
24. Chronotherapy
25. The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics 26. Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function
27. Functional anatomy of the bed nucleus of the stria terminalis-hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors
28. Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions
29. The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis
30. The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies
31. The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease.

Summary: "This book offers a unique perspective on the invisible organ, a body part that has been visualized only recently. It guides the readers into the world of the microbial constituents that make humans the way they are. The vitamins they produce, the smell they generate, the signals they create, and the molecular guards they elaborate are some of the benefits they bestow on humans. After introducing the notion as to why microbes are an integral component in the development of humans, the book examines the genesis of the microbiome and describes how the resident bacteria work in partnership with the skin, digestive tract, sexual organs, mouth and lungs to execute vital physiological functions. It then discusses the diseases that are triggered by the disruption of the harmonious relationships amongst these diverse systems and provides microbial cures to ailments such as obesity and digestive complications. Finally, the book focuses on the future when the workings of the human microbes will be fully unravelled. Societal changes in health education, the establishment of the microbiome bank, the fight against hunger, space travel, designer traits and enhanced security are explained. Each chapter is accompanied by captivating illustrations and ends with a visual summary. Dr. Appanna has been researching for over 30 years on various aspects of microbial and human cellular systems. He is a professor of biochemistry and has also served as Department Chair and Dean of the Faculty at Laurentian University, Sudbury, Canada. The book is aimed at readers enrolled in medical, chiropractic, nursing, pharmacy, and health science programs. Practicing health-care professionals and continuing education learners will also find the content beneficial."-- Provided by publisher.

Summary: The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. This book talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.

Contents:
1 Human Microbiome: Implication of Age and External factors
2 Oral Microbiome: An Opening to Healthy Possibilities
3 Emerging role of gut microbiota in functional gastrointestinal disorders
4 The Human Gut Microbiota and Gastrointestinal Cancer: Current Status and Therapeutic Perspectives
5 Genetic and Epigenetic Regulation by Gut Microbe-Modulated Metabolites in Chronic Metabolic Diseases
6 Gut Microbiota Related Clinical Events and Therapeutic Interventions in Alcohol Associated Liver Disease
7 Microbiota
Gut
Brain Axis in Neurological Disorders
8 Modern Perspectives in Controlling Human Diseases through Probiotic Intervention
9 Microbiome Association of Polypharmacy in Geriatric Population
10 Virome: Sentinels or marauders in the microbiome
11 Unlocking the Mysteries of the Human Microbiome to Combat COVID-19.

Contents:
An introduction to the human tissue microbiome. The human microbiota / Michael Wilson
An introduction to microbial dysbiosis / Mike Curtis
The gut microbiota / Herve M Blottiere, Joel Dore
The oral microbiota / William G Wade
The skin microbiota / Patrick LJM Zeeuwen, Joost Schalkwijk
Metagenomic analysis of the human microbiome / Luis G Bermudez-Humaran
Microbiota-microbiota and microbiota-host interactions in health and disease. Systems biology of bacteria-host interactions / Almut Heinken, Dmitry A Ravcheev, Ines Thiele
Bacterial biofilm formation and immune evasion mechanisms / Jessica Snowden
Co-evolution of microbes and immunity and its consequences for modern day life / Markus B Geuking
How viruses and bacteria have shaped the human genome / Frank Ryan
The microbiota as an epigenetic control mechanism / Boris A Shenderov
The emerging role of propionibacteria in human health and disease / Holger Bruggemann
Dysbioses and bacterial diseases. The periodontal diseases / Luigi Nibali
The polymicrobial synergy and dysbiosis model of periodontal disease pathogenesis / George Hajishengallis, Richard J Lamont
New paradigm in the relationship between periodontal disease and systemic diseases / Kazuhisa Yamazaki
The vaginal microbiota in health and disease / S Tariq Sadiq, Phillip Hay
Dysbioses and chronic diseases. Reactive arthritis / John D Carter
Rheumatoid arthritis / Jacqueline Detert
Inflammatory bowel disease and the gut microbiota / Nik Ding, Ailsa Hart
Ankylosing spondylitis, Klebsiella and the low-starch diet / Alan Ebringer, Taha Rashid, Clyde Wilson
Microbiome of chronic plaque psoriasis / Lionel Fry
Liver disease / Katharina Brandl, Bernd Schnabl
The gut microbiota / Frida Fak
The microbiota and susceptibility to asthma / Olawale Salami, Benjamin J Marsland
Microbiome and cancer / Ralph Francescone, Debora B Vendramini-Costa
Colorectal cancer and the microbiota / Iradj Sobhani, Severine Couffin
The gut microbiota and the CNS / Aadil Bharwani, Paul Forsythe
Genetic dysbiosis / Luigi Nibali
Mirroring the future. Diet and dysbiosis / Mehrbod Estaki, Candice Quin, Deanna L Gibson
Probiotics and prebiotics / Marie Jose Butel, Anne-Judith Waligora Dupriet
The microbiota as target for therapeutic intervention in pediatric intestinal diseases / Andrea Lo Vecchio, Alfredo Guarino
Microbial therapy for cystic fibrosis / Eugenia Bruzzese, Vittoria Buccigrossi, Giusy Ranucci, Alfredo Guarino.

Contents:
Scientific evidence for breastfeeding / Lucas, A.
The biomechanics of breastfeeding : bridging the gap between engineering-based studies and clinical practice / Woolridge, M.
Summary of session 1 / Lucas, A.
Physiological effects of feeding infants and young children formula supplemented with milk fat globule membranes / Hernell, O.; Domellöf, M.; Grip, T.; Lönnerdal, B.; Timby, N.
Human milk oligosaccharides : factors affecting their composition and their physiological significance / Sprenger, N.; Binia, A.; Austin, S.
Fatty acids and fat-soluble vitamins in breast milk : physiological significance and factors affecting their concentrations / Morrow, A.L.; Dawodu, A.
Water-soluble vitamins in human milk : factors affecting their concentration and their physiological significance / Allen, L.H.; Hampel D.
Human milk micrornas/exosomes : composition and biological effects / Lönnerdal, B.
Human milk proteins : composition and physiological significance / Donovan, S.M.
Summary of session 2 / Lönnerdal, B.
Early-life nutrition, growth trajectories, and long-term outcome / Haschke, F.; Binder, C.; Huber-Dangl, M.; Haiden, N.
Early-life nutrition and cognitive development : imaging approaches / Lin, W.; Baluyot, K.R.; Yao, M.; Yan, J.; Wang, L.; Li, G.; Howell, B.; Elison, J.T.; Shen, D.
Early-life nutrition and gut immune development / van den Elsen, L.; Rekima, A.; Verhasselt, V.
Early-life nutrition and microbiome development / Isolauri, E.; Rautava, S.; Salminen, S.; Collado, M.C.
Human milk and clinical outcomes in preterm infants / Meier, P.P.
Summary of session 3 / Donovan, S.M.
Metabolomics in human milk research / Slupsky, C.M.
Human milk oligosaccharides : next-generation functions and questions / Bode, L.
Guiding development of the neonate : lessons from mammalia / Nicholas, K.R.; Modepalli V.; Watt, A.P.; Hinds, L.A.; Kumar, A.; Lefevre, C.; Sharp, J.A.
Milk lipids : a complex nutrient delivery system / German, J.B.; Argov-Argaman, N.; Boyd, B.
Summary of session 4 / German, J.B.

Summary: Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Key features: Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms Summary boxes at the end of each chapter provide clear learning points Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study Reorganized into five sections for improved access to related topics Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.

Contents:

Part 1: Basics of DNA, Chromosomes, Cells, Development, and Inheritance1. Basic Principles of Nucleic Acid Structure and Gene Expression. 2. Fundamentals of Cells and Chromosomes. 3. Fundamentals of Cell-Cell Interactions and Immune System Biology. 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells. 5. Patterns of Inheritance.
Part 2: Understanding Genomes6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing. 7. Analyzing the Structure and Expression of Genes and Genomes. 8. Principles of Genetic Manipulation of Mammalian Cells. 9. Uncovering the Architecture and Workings of the Human Genome. 10. Gene Regulation and the Epigenome.
Part 3: Genetic Variation Between Individuals and Species11. An Overview of Human Genetic Variation. 12. Human Population Genetics. 13. Comparative Genomics and Genome Evolution. 14. Human Evolution.
Part 4: Human Genetic Disease15. Chromosomal Abnormalities and Structural Variants. 16. Molecular Pathology: Connecting Phenotypes to Genotypes. 17. Mapping and Identifying Genes for Monogenic Disorders. 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis. 19. Cancer Genetics and Genomics.
Part 5: Applied Human Molecular Genetics 20. Genetic Testing in Healthcare and the Law. 21. Model Organisms and Modeling Disease. 22. Genetic Approaches to Treating Disease.

Contents:
Human monoclonal antibodies : the residual challenge of antibody immunogenicity / Herman Waldmann
Technical and ethical limitations in making human monoclonal antibodies (an overview) / Mark C. Glassy and Rishab Gupta
Therapeutic human monoclonal antibodies in inflammatory diseases / Sotirios Kotsovilis and Evangelos Andreakos
Therapeutic human monoclonal antibodies against cancer / Jamie Jarboe, Anumeha Gupta, and Wasif Saif
Polyclonal and monoclonal antibodies in clinic / Bharath Wootla, Aleksandar Denic, and Moses Rodriguez
Production of human monoclonal Antibodies by the Epstein-Barr virus method / Michael Steinitz
Humanization and simultaneous optimization of monoclonal antibody / T. Kuramochi, T. Igawa, H. Tsunoda, and K. Hattori
Chimeric Antibodies / Kohei Kurosawa, Waka Lin, and Kunihiro Ohta
Recombinant genetic libraries and human monoclonal antibodies / Jarrett J. Adams, Bryce Nelson, and Sachdev S. Sidhu
Production of stabilized scFv antibody fragments in the E. coli bacterial cytoplasm / Lilach Vaks and Itai Benhar
Construction and production of an IgG-like tetravalent bispecific antibody, IgG-single-chain Fv fusion / Dan Lu and Zhenping Zhu
Construction of human antibody gene libraries and selection of antibodies by phage display / André Frenzel [and others]
Antigen-specific human monoclonal antibodies from transgenic mice / Susana Magadán Mompó and África González-Fernández
Phage display technology for human monoclonal antibodies / Cecilia Deantonio [and others]
Antigen-specific in vitro immunization : a source for human monoclonal antibodies / Kosuke Tomimatsu and Sanetaka Shirahata
Methods for radiolabelling of monoclonal antibodies / Vladimir Tolmachev, Anna Orlova, and Karl Andersson
Purification of human monoclonal antibodies and their fragments / Thomas Müller-Späth and Massimo Morbidelli
Idiotype-specific intravenous immunoglobulin (IVIG) for therapy of autoimmune diseases / Miri Blank, Tomer Bashi, and Yehuda Shoenfeld.

Contents:
1. Advances in the comprehension of the diet as a magic bullet to prevent cancer of the gastrointestinal system
2. How a gastroenterologist interprets the mediterranean diet
3. The gut microbiota and obesity in humnas
4. Gut-brain axis: a new revolution to understand the pathogenesis of autism and other severe neurological diseases
5. Does diet still retain a value in gastrointestinal pathology?
6. Diet as therapy for IBD?
7. Diverticular diseases and western diet: another metropolitan legend?
8. How much fat does one need to eat to get a fatty liver? a dietary view of NAFLD
9. Tasters, supertasters, genes and environment: how dietary choices influence our health
10. From food map to FODMAP in irritable bowel syndrome
11. The role of diet in counteracting gastroparesis
12. How the precious role of wine in mediterranean diet is mediated by the gastrointestinal tract
13. Why overweight/obesity leads to GERD.

Summary: "Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted"--Publisher's description.

Contents:
Human papillomavirus genomics : past, present and future / Harari, A., Chen, Z., Burk, R.D.
The biology of human papillomaviruses / Nguyen, H.P., Ramirez-Fort, M.K., Rady, P.L.
Viral oncogenesis / Doan, H.Q., Ramirez-Fort, M.K., Rady, P.L.
Pathogenesis of infection by human papillomavirus / Brendle, S.A., Bywaters, S.M., Christensen, N.D.
Host responses to infection with human papillomavirus / Stanley, M.A.; Sterling, J.C.
Cutaneous human papillomavirus infection : manifestations and diagnosis / Tschandl, P., Rosendahl, C., Kittler, H.
Epidermodysplasia verruciformis / Burger, B., Itin, P.H.
Human papillomavirus infections of the oral mucosa and upper respiratory tract / Nguyen, H.P., McNiece, K.L., Duong, A.A., Khan, F.
Human papillomavirus and immunosuppression / Wieland, U., Kreuter, A., Pfister, H.
Laboratory diagnosis of human papillomavirus infection / Ikenberg, H.
Management of cutaneous human papillomavirus infection: pharmacotherapies / Ramirez-Fort, M.K.; Au, S.-C., Javed, S.A., Loo, D.S.
Management of cutaneous human papillomavirus infection : surgery / Ramirez-Fort, M.K., Sam, H., Manders, E.K.
Management of cutaneous human papillomavirus infection in immunocompromised patients / Varada, S., Posnick, M., Alessa, D., Ramirez-Fort, M.K.
Management of human papillomavirus-related gynecological malignancies / Heinzelmann-Schwarz, V.A., Kind, A.B., Jacob, F.
Management of human papillomavirus-related anal and colon cancer / Yen Moore, A., Tong, L.X., Moore, T.
Management of human papillomavirus-related head and neck cancer / Coughlin, A.M., Qiu, S., Underbrink, M.P.
Vaccines and immunization against human papillomavirus / Christensen, N.D., Budgeon, L.R.

Summary: This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.

Contents:
Part 1 Metabolic Disorders. Citrin deficiency"
Homocystinuria No Acquaintance
Phenylketonuria
Urea cycle disorders (such as defects of OTCD)"
Wilson disease
Diabetes Mellitus type I
Lipid storage disorder, namely Niemann-Pick C1 disease
Gaucher disease
Fabry disease
Mitochondrial disease (such as defects of MELAS)
Heme oxygenase deficiency
Collagen metabolism (such as OI)
Organic acid metabolism disorders
Part 2 Genetic Disorders. Glucose 6-Phosphate Dehydrogenase Deficiency
Familial Hypercholesterolemia
Fukuyama muscular dystrophy
Hemoglobin
Huntington disease
Anti-coagulant deficiency
Auto-inflammatory disorders
Cancer
Marfan syndrome
Human immunodeficiency virus infection
Hepatitis virus C
Cytomegalovirus infection (especially congenital infection)
Addiction.

Contents:
Intro
Human Pluripotent Stem Cell Derived Organoid Models
Copyright
Contents
Contributors
Chapter 1: Generation of esophageal organoids and organotypic raft cultures from human pluripotent stem cells
1. Introduction
2. Significance and applications
3. Morphological and transcriptional analysis of developing esophageal cultures
4. Overview of differentiation protocol
5. Step-by-step protocol
5.1. Coating plates for stem cell culture maintenance and directed differentiation
5.1.1. Materials and reagents
5.1.2. Protocol 5.2. Differentiation of stem cells into esophageal organoids
5.2.1. Materials, reagents and equipment
5.2.2. Solutions preparation
5.2.3. Protocol (Fig. 2A)
5.2.3.1. hPSC dissociation and plating in 24-well plate (day-1)
5.2.3.2. Differentiation protocol
5.2.3.3. Embedding foregut spheroids in Matrigel
5.2.3.4. Reduction of HEOs density
5.3. Esophageal raft culture protocol
5.3.1. Materials and reagents
5.3.2. Coating 100mm plates with collagen IV
5.3.3. Dissociation of HEOs and culturing in keratinocyte media 5.3.4. Preparing collagen-Mouse fibroblasts gels for raft cultures
5.3.5. Transferring cells from keratinocyte media to raft cultures
5.4. Immunofluorescence analysis of HEOs and organotypic raft cultures (Fig. 4)
5.4.1. Materials and reagents
5.4.2. Tissue fixation, preparation and cryosection
5.4.3. Immunofluorescent protocol
6. Future directions
7. Summary
Acknowledgments
References
Chapter 2: Generation and use of gastric organoids for the study of Helicobacter pylori pathogenesis
1. Introduction
2. Significance and applications of gastric organoids 3. Overview of the protocol
4. Step-by-step protocol
4.1. Generation of human-derived gastric organoids from normal and tumor tissues
4.1.1. Materials and reagents
4.1.2. Procedure: Generation of human-derived normal gastric organoids
4.1.3. Procedure: Generation of human-derived tumor gastric organoids
4.2. Generation of human-PBMC derived immune cells
4.2.1. Materials and reagents
4.2.2. Procedure: Isolation of PBMCs from whole blood using Ficoll-Paque density gradient medium
4.2.3. Procedure: Isolation of PBMCs from whole blood using Lymphoprep 4.2.4. Procedure: Freezing of PBMCs
4.2.5. Procedure: Culture of dendritic cells (DCs)
4.2.6. Procedure: Culture of cytotoxic T lymphocytes (CTLs)
4.2.7. Procedure: Culture of myeloid-derived suppressor cells (MDSCs)
4.3. Organoid/immune cell co-culture
4.3.1. Procedure: DCs and CTL co-culture
4.3.2. Procedure: Organoid-immune cell co-culture
4.4. Orthotopic transplantation
4.4.1. Materials and reagents
4.4.2. Procedure: Orthotopic transplantation of human-derived gastric organoids
5. Precursor techniques
6. Safety considerations and standards

Summary: This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

Contents:
Intro
Preface
Contents
Part I Population Genetic Theory
1 Coalescent Models
1.1 Aims and Clarifications
1.2 Introduction: Gene Genealogies Within a Population or Species
1.2.1 Organismal Pedigrees and Gene Genealogies
1.3 The Standard Neutral Model: The Kingman Coalescent
1.3.1 The Sampling Structure of Coalescent Gene Genealogies
1.3.2 Including Mutations in the Coalescent
1.4 Fundamental Predictions for Single Loci in Well-Mixed Populations
1.4.1 The Size and Shape of a Gene Genealogy
1.4.2 Levels and Patterns of Genetic Variation 1.4.3 Tests of the Standard Neutral Coalescent Based on Site Frequencies
1.5 Extensions of the Standard Model
1.5.1 Fluctuations in Population Size over Time
1.5.2 Population Subdivision and Migration
1.6 Conclusion: Current Challenges of Big Data
References
2 Linkage Disequilibrium
2.1 Introduction
2.2 Tests of whether D == 0
2.3 More than Two Alleles per Locus
2.4 More than Two Loci: Haplotype Blocks and the HapMap Project
2.5 Dynamics of D
2.6 Genetic Drift and LD
2.7 Genealogical Interpretation of LD
2.8 Natural Selection and LD 2.9 Genetic Hitchhiking
2.10 Population Subdivision
2.11 Conclusion
References
3 Analysis of Population Structure
3.1 What Is Population Structure?
3.2 Individual-Based and Unsupervised Methods for Inferring Population Structure
3.2.1 Tree Construction Methods at the Individual Level
3.2.2 Principal Component Analysis and Related Approaches
3.2.3 Ancestry Component Estimation with Few Model Assumptions
3.3 Population-Based and Supervised Methods
3.3.1 Genetic Differentiation at the Population Level
3.3.1.1 FST
3.3.1.2 Other Measures of Genetic Distance 3.3.2 Formal Tests for Admixture Under a Population Tree-Model
3.3.3 More Advanced Modeling
3.3.3.1 Population Graph Fitting
3.3.3.2 Isolation-Migration Models
3.3.3.3 Approximate Bayesian Computation
3.4 Summary and Guidelines
References
4 Types of Natural Selection and Tests of Selection
4.1 Types of Selection and Their Effect on Linked Neutral Sites
4.1.1 Types of Selection
4.1.2 The Effect of Selection on Linked Neutral Sites
4.2 Tests of Selection
4.2.1 Tests of Selection Based on the Site Frequency Spectrum
4.2.1.1 Tajima's D
4.2.1.2 Fay and Wu's H 4.2.1.3 Likelihood Ratio Tests
4.2.2 Tests of Selection Based on Haplotypes
4.2.2.1 Extended Haplotype Homozygosity (EHH)
4.2.2.2 Integrated Haplotype Score (iHS)
4.2.2.3 Cross-Population EHH (XP-EHH)
4.2.3 Tests Based on both Diversity and Divergence:The McDonald-Kreitman Test
4.3 How to Choose a Specific Test of Selection?
References
Part II Association Studies and Medical Genetics
5 Methods for Association Studies
5.1 Introduction
5.2 Types of Association Studies
5.2.1 Candidate Gene Studies
5.2.2 Genome-Wide Association Studies
5.2.2.1 Background

Summary: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems"--Publisher's description.

Contents:
Historical view
Section I: Pathophysiology of prions. The cellular and pathological prion protein
Cell biology of prion infection
Experimental models of human prion diseases and prion strains
The role of the immune system in prion infection
Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes). Typical and atypical scrapie
Typical and atypical BSE
Chronic Wasting Disease
Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes). Sporadic Creutzfeldt-Jakob Disease
Variably protease-sensitive prionopathy
Variant Creutzfeldt-Jakob Disease
Iatrogenic Creutzfeldt-Jakob Disease
Genetic Creutzfeldt-Jakob Disease
Gerstmann-Sträussler-Scheinker disease
Sporadic and fatal Familial Insomnia
Section IV: Prion-like mechanisms in other neurodegenerative diseases. Prion-like mechanisms in Alzheimer
Prion-like mechanisms in Parkinson
Prion-like mechanisms in ALS
Section V: Diagnosis and treatment. Prion protein amplification techniques
Differential diagnosis with other rapid progressive dementias
Symptomatic treatment, care and support of CJD patients
Identifying therapeutic targets and treatment in model systems
Vaccination strategies
Clinical trials
Section VI: Public health issues. Animal diseases and the zoonotic potential
Safety of blood, blood derivatives and plasma-derived products
Safety in clinical practice
Concluding thoughts.

Contents:
Sperm Selection Techniques and their Relevance to ART / Luke Simon, Monis B Shamsi, Douglas T Carrell
In Vitro Maturation of Human Oocytes: Current Practices and Future Promises / Catherine MH Combelles
Molecular Biology of Endometriosis / Jayasree Sengupta, G Anupa, Muzaffer Ahmed Bhat, Debabrata Ghosh
Novel Immunological Aspects for the Treatment of Age-induced Ovarian and Testicular Infertility, Other Functional Diseases, and Early and Advanced Cancer Immunotherapy / Antonin Bukovsky
Mitochondrial Manipulation for Infertility Treatment and Disease Prevention / Tetsuya Ishii
Novel Imaging Techniques to Assess Gametes and Preimplantation Embryos / Jason E Swain
Clinical Application of Methods to Select In Vitro Fertilized Embryos / Kirstine Kirkegaard, Thomas F Dyrlund, Hans Jakob Ingerslev
New Horizons/Developments in Time-Lapse Morphokinetic Analysis of Mammalian Embryos / Serdaroğullari Munevver, Necati Findikli, Mustafa Bahceci
The Non-Human Primate Model for Early Human Development / Stuart Meyers, Renee Riejo-Pera
Cytoskeletal Functions, Defects, and Dysfunctions Affecting Human Fertilization and Embryo Development / Heide Schatten, Qing-Yuan Sun.

Contents:
Retrotransposons and the Mammalian Germline
L1 regulation in Mouse and Human Germ Cells
Retrotransposon Contribution to Genomic Plasticity
The Mobilization of Processed Transcripts in Germline and Somatic Tissues
Neuronal Genome Plasticity: Retrotransposons, Environment and Disease
Activity of Retrotransposons in Stem Cells and Differentiated Cells
Environment, Cellular Signaling and L1 activity
Retrotransposon-derived Regulatory Regions and Transcripts in Stemness
Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation
Alu-Alu Recombinations in Genetic Diseases
Retrotransposon-driven Transcription and Cancer
LINE-1 retrotransposons as Neoplastic Biomarkers
Contribution of Retrotransposable Elements to Aging.

Contents:
Virion attachment and entry : HIV gp120 env biotinylation, gp120 env, or integrin ligand-binding assay / Claudia Cicala and James Arthos
CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5[alpha] / Gongpu Zhao and Peijun Zhang
The fate of HIV-1 capsid : a biochemical assay for HIV-1 uncoating / Yang Yang, Jeremy Luban, and Felipe Diaz-Griffero
The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells / Amy E. Hulme and Thomas J. Hope
Imaging HIV-1 nuclear pre-integration complexes / Anna Cereseto and Mauro Giacca
HIV-1 reverse transcription / Andrea Cimarelli and Jean-Luc Darlix
RNase H : specificity mechanisms of action, and antiviral target / Karin Moelling, Felix Broecker, and John E. Kerrigan
HIV-1 chromatin, transcription, and the regulatory protein Tat / Laurence Colin, Eric Verdin, and Carine Van Lint
HIV-1 Rev function and RNA nuclear-cytoplasmic export / Alan Cochrane
HIV-1 accessory proteins : Nef / Anke Heigele [and three others]
HIV-1 accessory proteins : VpR / Richard Y. Zho and Michael I. Bukrinsky
HIV-1 accessory proteins : Vpu and Vif / Amy Andrew and Klaus Strebel
SIVSM/HIV-2 Vpx proteins : function and uses in the infection of primary myeloid cells / Gregory Berger and Andrea Cimarelli
Imaging of HIV assembly and release / Barbara Müller and Jacomine Krijnse-Locker
HIV-1 isolation from infected peripheral blood mononuclear cells / Stefania Dispinseri [and four others]
Determination of HIV-1 co-receptor usage / Mariangela Cavarelli and Gabriella Scarlatti
The macrophage and HIV : basic concepts and methodologies / Suzanne Gartner
HIV infection of dendritic cells / Najla Nasr [and three others]
Histocultures (tissue explants) in human retrovirology / Anush Arakelyan [and four others]
Single-copy quantification of HIV-1 in clinical samples / Ann Wiegand and Frank Maldarelli
Quantification of total HIV1-DNA in peripheral blood mononuclear cells / Christine Rouzioux, Adeline Mélard, and Véronique Avéttand-Fénoël
HIV-1 based lentiviral vectors / Ying Poi Liu and Ben Berkhout
Quantification of miRNA by poly(A)-RT-qPCR arrays and verification of target sites in HIV-1 using a one-LTR infectious molecular clone / Zachary A. Klase, Laurent Houzet, and Kuan-Teh Jeang
Investigating human T cell lymphotropic retrovirus (HTLV) Tax function with molecular and immunophenotypic techniques / Greta Forlani, Roberto S. Accolla, and Giovanna Tosi
Proviral load determination of HTLV-1 and HTLV-2 in patients' peripheral blood mononuclear cells by real-time PCR / Claudio Casoli, Elisabetta Pilotti, and Umberto Bertazzoni
Quantitative analysis of human T-lymphotropic virus type 1 (HTLV-1) gene expression using nucleo-cytoplasmic fractionation and splice junction-specific real-time RT-PCR (qRT-PCR) / Ilaria Cavallari, Francesca Rende, and Vincenzo Ciminale.

Contents:
Introduction
I. Prospects and limitations of neuroscience research in the humanities and social sciences. Neurophilosophy or philosophy of neuroscience? : what neuroscience and philosophy can and cannot do for each other / Michael Jungert
Philosophical puzzles evade empirical evidence : some thoughts and clarifications regarding the relation between brain sciences and philosophy of mind / Işik Sarihan
"Who's afraid of the big bad neuroscience?" : neuroscience's impact on our notions of self and free will / Rui Vieira da Cunha and João Bettencourt Relvas
Free will--between philosophy and neuroscience / Anna Drozdzewska
Histories of the brain : toward a critical interaction of the humanities and neurosciences / Mattia Della Rocca
II. The neurosciences of social sciences and ethics. The theory of brain-sign : a new model of brain operation / Philip Clapson
On the redundancies of "social agency" / Alexandros Tillas
Two kinds of reverse inference in Cognitive neuroscience / Guillermo del Pinal and Marco J. Nathan
The neuroscience of ethics beyond the is-ought orthodoxy : the example of the dual process theory of moral judgment / Nadia El Eter
III. The neurosciences in society : social, cultural, and ethical implications of the neuro-turn. Effects of the neuro-turn : the neural network as a paradigm for human self-understanding / Yvonne Förster
Brain, art, salvation : on the traditional character of the neuro-hype / Gerd Grübler
"A mind plague on both your houses" : imagining the impact of the neuro-turn on the neurosciences / Melissa M. Littlefield
Being a good external frontal lobe : parenting teenage brains / Ties van de Werff
Toward neuroscience literacy? : theoretical and practical considerations / Alexander Bergmann, Anne Biehl and Jörg Zabel
"Strangers" in neuroscientific research / Berit Bringedal, Markus Christen, Nikola Biller-Andorno, Hironori Matsuzaki and Alberto Rábano
At the push of a button, narrative strategies and the image of deep brain stimulation / Oonagh Hayes.

Summary: 'An engaging, compelling and disturbing confrontation with evil...abook that will be transformative in its call for individual and collective moral responsibility." - Michael A. Grodin, M.D., Professor and Director, Project on Medicine andtheHolocaust, Elie Wiesel Center for Judaic Studies, Boston University Human Subjects Research after the Holocaust challenges you to confront the misguided medical ethics of the Third Reich personally, and to apply the lessons learned to contemporary human subjects research. While it is comforting to believe that Nazi physicians, nurses, and bioscientists were either incompetent, mad, or few in number, they were, in fact, the best in the world at the time, and the vast majority participated in the government program of 'applied biology.' They were not coerced to behave as they did-they enthusiastically exploited widely accepted eugenic theories to design horrendous medical experiments, gas chambers and euthanasia programs, which ultimately led to mass murder in the concentration camps. Americans provided financial support for their research, modeled their medical education and research after the Germans, and continued to perform unethical human subjects research even after the Nuremberg Doctors' Trial. The German Medical Association apologized in 2012 for the behavior of its physicians during the Third Reich. By examining the medical crimes of human subjects researchers during the Third Reich, you will naturally examine your own behavior and that of your colleagues, and perhaps ask yourself "If the best physicians and bioscientists of the early 20th century could do evil while believing they were doing good, can I be certain that I will never do the same?" · Presents relatively unknown aspects of human subjects research during the Third Reich · Reveals surprising relationships between German and American human subjects research · Dispels myths about Nazi human subjects research · Compels introspection and self-examination by today's medical and research practitioners · Addresses contemporary bioethical issues affecting vulnerable populations · Brings together experts in the history of medicine during the Third Reich and thoughtful new voices

Contents:
Introduction: How Did It Go So Wrong?
Twin Experiments at Auschwitz: A First-Person Account
Eugenics and Racial Hygiene: Applied Research Strategies before, during, and after National Socialism
Medical Ethics and Medical Research on Human Beings in National Socialism
Sulfonamide Experiments on Prisoners in Nazi Concentration Camps: Coherent Scientific Rationality Combined with Complete Disregard of Humanity
Stages of Transgression: Anatomical Research in National Socialism
Nurses and Human Subjects Research during the Third Reich and Now
Involuntary Abortion and Coercive Research on Pregnant Forced Laborers in National Socialism
Abusive Medical Practices on "Euthanasia" Victims in Austria during and after World War II
Medical Research and National Socialist Euthanasia: Carl Schneider and the Heidelberg Research Children from 1942 until 1945
Victims of Human Experiments and Coercive Research under National Socialism: Gender and Racial Aspects
The White Rose: Resisting National Socialism-with an Introduction by Susan Benedict
The Origins and Impact of the Nuremberg Doctors' Trial
In the Shadow of Nuremberg: Unlearned Lessons from the Medical Trial
The Ethics of Medical Experiments: Have We Learned the Lessons of Tuskegee and the Holocaust?
Human Subjects Research during and after the Holocaust: Typhus Vaccine Development and the Legacy of Gerhard Rose
Ethics in Space Medicine: Holocaust Beginnings, the Present, and the Future
Reproduction Then and Now: Learning from the Past
Promoting Clinical Research and Avoiding Bad Medicine: A Clinical Research Curriculum
The Psychophysiology of Attribution: Why Appreciative Respect Can Keep Us Safe
Confronting Medicine during the Nazi Period: Autobiographical Reflections
Teaching the Holocaust to Medical Students: A Reflection on Pedagogy and Medical Ethics
No Exceptions, No Excuses: A Testimonial.

Summary: The principal objective of this book is to provide information needed to define human thermal behavior quantitatively. Human thermal physiology is defined using mathematical methods routinely employed by physicists and engineers, but seldom used by physiologists. Major sections of the book are devoted to blood flow, sweating, shivering, heat transfer within the body, and heat and mass transfer from skin and clothing to the environment. Simple algebraic models based on experimental data from a century of physiological investigation are developed for bodily processes. The book offers an invaluable source of information for physiologists and physical scientists interested in quantitative approaches to the fascinating field of human thermoregulation.

Contents:
Animal heat and thermal regulation
Conservation of energy
Temperature measurement
Circulation
Sweating
Shivering
Temperature distribution in the body
Clothing
Heat and mass transfer from the skin and clothing
The development of a mathematical human thermal model.

Summary: "This clear-sighted reference examines the public health dimensions of labor and sex trafficking in the United States, the scope of the crisis, and possibilities for solutions. Its ecological lifespan approach globally traces risk and protective factors associated with this exploitation, laying a roadmap towards its prevention. Diverse experts, including survivors, describe support and care interventions across domains and disciplines, from the law enforcement and judicial sectors to community health systems and NGOs, with a robust model for collaboration. By focusing on the humanity of trafficked persons, a public health paradigm broadens our understanding of and ability to address trafficking while adding critical direction and resources to the criminal justice and human rights structures currently in place. Among the topics covered: Children at Risk: Foster Care and Human Trafficking LGBTQ Youth and Vulnerability to Sex Trafficking Physical Health of Human Trafficking Survivors: Unmet Essentials Research Informing Advocacy: An Anti-Human Trafficking Tool Caring for Survivors Using a Trauma-Informed Care Framework The Media and Human Trafficking: Discussion and Critique of the Dominant Narrative Human Trafficking Is a Public Health Issue is a sobering read; a powerful call to action for public health professionals, including social workers and health care practitioners providing direct services, as well as the larger anti-trafficking community of advocates, prosecutors, taskforce members, law enforcement agents, officers, funders, and administrators. "An extraordinary collection of knowledge by survivors, academics, clinicians, and advocates who are experts on human trafficking. Human Trafficking is a Public Health Issue is a comprehensive offering in educating readers on human trafficking through a multi-pronged public health lens. Margeaux Gray: Survivor, Advocate, Artist, Public Speaker"--Page 4 of cover.

Contents:
Introduction to Human Trafficking: Who Is Affected? / Jordan Greenbaum
Sex Trafficked and Missed / Wendy J. Barnes and Holly Austin Gibbs
The Lost Boy: How a Forgotten Child Became a Victim of Labor Trafficking / James L. Dold
Sex Trafficking in the USA / Clydette L. Powell and Cyril Bennouna
The Ignored Exploitation: Labor Trafficking in the United States / Nicole Littenberg and Susie Baldwin
Trafficking of Children Within the United States / Carol Smolenski and Sarah Ingerman
Children at Risk: Foster Care and Human Trafficking / Madeline Hannan, Kathryn Martin, Kimberly Caceres, and Nina Aledort
Sex Trafficking in Indian Country / Erin Shanley and Robyn Jordan
LGBTQ Youth and Vulnerability to Sex Trafficking / Kathryn Xian, Shaylin Chock, and Dustin Dwiggins
The Multimodal Social Ecological (MSE) Approach: A Trauma-Informed Framework for Supporting Trafficking Survivors' Psychosocial Health / Elizabeth K. Hopper
Physical Health of Human Trafficking Survivors: Unmet Essentials / Wendy Macias-Konstantopoulos and Zheng B. Ma
Trauma-Informed Treatment of Substance Use Disorders in Trafficking Survivors / Elizabeth K. Hopper
The Development and Psychology of Young Minds: Communities Can Prevent Exploitation and Facilitate Rehabilitation / Sandra Gasca-Gonzalez and Dianna L. Walters
Legal Supports for Trafficked Persons: Assisting Survivors via Certification, State/Federal Benefits, and Compensation / Lennon Moore and Brendan Milliner
NGOs and the Anti-Trafficking Movement: Advocacy and Service / Valerie Schmitt
The Role of Faith-Based Organizations in the US Anti-Trafficking Movement / Jeffrey Barrows
Research Informing Advocacy: An Anti-Human Trafficking Tool / Cathy L. Miller and Michelle Lyman
Caring for Survivors Using a Trauma-Informed Care Framework / Annie Lewis-O'Connor and Elaine J. Alpert
Sex Trafficking in One US City: Traditional Policing and Boston's Shift to a Survivor-Centered Response / Donna Gavin and Cassandra Thomson
The Role of Community Health Centers in Addressing Human Trafficking / Kimberly S.G. Chang and A. Seiji Hayashi
The Media and Human Trafficking: A Discussion and Critique of the Dominant Narrative / Erin Albright and Kate D'Adamo
Human Trafficking: Perspectives on Prevention / Elaine J. Alpert and Sharon E. Chin
Combating Modern Bondage: The Development of a Multi-Disciplinary Approach to Human Trafficking / Laura J. Lederer
Moving Forward: Next Steps in Preventing and Disrupting Human Trafficking / Katherine Y. Chon and Smitha Khorana.

Summary: "Human-wildlife conflict (HWC) is one of the most complex and urgent issues facing wildlife management and conservation today. Originally focused on the ecology and economics of wildlife damage, the study and mitigation of HWC has gradually expanded its scope to incorporate the human dimensions of the whole spectrum of human-wildlife relationships, from conflict to coexistence. Having the conflict-to-coexistence continuum as its leitmotiv, this book explores a variety of theories and methods currently used to address human-wildlife interactions, illustrated by case studies from around the world. It presents some key concepts in the field, such as values, emotions, social identity and tolerance, and a variety of insights and solutions to turn conflict into coexistence, from individual level to national scales, including conservation marketing, incremental and radical innovation, strategic planning, and socio-ecological systems. This volume will be of interest to a wide range of readers, including academics, researchers, students, practitioners and policy-makers"-- Provided by publisher.

Summary: This original, eloquent, compassionate, and timely book offers all healthcare practitioners interested and involved in addiction practice a powerful account of an addiction psychiatrist's journey of professional and personal growth, thereby offering readers a unique opportunity to learn deeply from the author's insights, experiences, and struggles in becoming a patient-centered empathic healer. Through sharing and exploring clinical experiences in addiction practice, this fascinating title delves into the lead author and his mentee's personal, professional, and ethical challenges and weaves together science and humanism, offering a wealth of experiential wisdom and tools that have the power to transform our understanding of therapeutic work with people with addictions. Written with empathy and humility, Humanizing Addiction: Blending Science and Personal Transformation provides a compelling argument and framework for integrating humanism with empirically grounded practices. This important book is an invaluable resource for healers from a range of backgrounds: physicians, physician assistants, nurse practitioners, social workers, case managers, patient navigators, clinical and health psychologists, pharmacists, counselors, graduate students, and medical trainees involved in clinical care of people with addiction and substance use problems.

Summary: This book was written by the creators of the Difficult Airway Course: Anesthesia, this illustrated and extensively referenced text delivers a comprehensive review of the latest options available for airway management and offers expert coverage of the full spectrum of airway management techniques. Within its pages you will find the most up-to-date review available of the many innovations that been introduced since publication of the previous edition. This is accompanied by a thorough review of the pharmacology of airway management designed to help you understand how to achieve the desired effects on ventilation and muscle strength. You will also find numerous algorithms, many of which have been revised for this edition. ... These cases teach trainees the fundamental approaches to airway management, and include self-evaluation questions to reinforce the lesson. For experienced anesthesiologists, the cases present an opportunity to learn about recently introduced devices and techniques they may wish to incorporate into their clinical practice.

Contents:
Principles of airway management
Airway techniques
Pre-hospital airway management
Airway management in the emergency room
Airway management in the intensive care unit (ICU)
Airway management in the operating room
Airway management in the pediatric population
Airway in the obstetrics
Airway management in unique environment
Practical considerations in airway management.

Summary: Roxane Gay addresses the experience of living in a body that she calls 'wildly undisciplined.' She casts an insightful and critical eye over her childhood, teens, and twenties -- including the devastating act of violence that was a turning point at age 12 -- and brings readers into the present and the realities, pains, and joys of her daily life. With candor, vulnerability, and authority, Roxane explores what it means to be overweight in a time when the bigger you are, the less you are seen.

Summary: "Hunter-gatherer lifestyles defined the origins of modern humans and for tens of thousands of years were the only form of subsistence our species knew. This changed with the advent of food production at different times throughout the world. The chapters in this volume explore the different way that hunter-gatherer societies around the world adapted to changing social and ecological circumstances while still maintaining a predominantly hunter-gatherer lifestyle. Couched specifically with the framework of resilience theory, the authors use contextualized bioarchaeological analyses of health, diet, mobility, and funerary practices to explore how hunter-gatherers in different parts of the world responded to challenges and actively resisted change that formed the core of their social identity and worldview"-- Provided by publisher.

Contents:
Part 1: Clinical practice in the tropics. Section A: Organ-based chapters. Tropical lung diseases
Cardiovascular diseases
Gastrointestinal diseases
Hepatobiliary diseases
Hematologic diseases
Genitourinary diseases
Sexually transmitted infections
Tropical dermatology
Ophthalmological diseases
Neurologic diseases
Psychiatric diseases
ENT
Diseases of the musculoskeletal system
Section B: Skills-based chapters. General surgery in the tropics
Oral health and disease in the tropics
Maternal and newborn health
Pediatrics in a resource-constrained setting
Section C: Service-based chapters. Diagnostic imaging in the tropics
Blood transfusion in resource-limited settings
Infection control in the tropics
Microbiology
Section D: Topic-based chapters. Approach to the patient with diarrhea
Cancer in the tropics
Heat-associated illness
Traditional medicine
Environmental health hazards in the tropics
Neglected tropical diseases: public health control programs and mass drug administration
Health systems and health care delivery
The health care response to disasters, complex emergencies, and population displacement
Part 2: Viral diseases. Introduction and general principles
Human immunodeficiency virus infection
HIV, tuberculosis, malaria and Streptococcus pneumoniae
Viral infections with cutaneous lesions
Measles
Poxviruses
Nonpolio enterovirus mucocutaneous infections
Kaposi's sarcoma-associated herpesvirus
Viral respiratory infections
Viral gastroenteritis
Rotavirus
Norovirus
Enteric adenoviruses
Astroviruses
Sapovirus
Viral hepatitis (Hep A, B, C, D, E and non A to E)
Viral febrile illnesses and emerging pathogens
Dengue and Dengue hemorrhagic fever
Chikungunya fever
Zika
O'nyong Nyong fever
Ross River virus disease
Oropouche virus
Mayaro virus
Pathogenic phleboviruses (old: sandfly fever)
Sindbis fever
Viral hemorrhagic fevers: introduction
Yellow fever
Lassa fever
South American hemorrhagic fevers
Ebola and Marburg virus infections
Crimean-Congo hemorrhagic fever
Diseases caused by hantaviruses
Rift Valley fever
Viral CNS infections
Rabies & related viruses
Enterovirus infections that cause central nervous system disease (including poliomyelitis)
Venezuelan, Eastern and Western equine encephalitis
Japanese encephalitis
West Nile virus
Saint Louis encephalitis and Rocio encephalitis
Other arboviral encephalitides
Prion disease
Human T-lymphotropic virus type I and II infection
Part 3: Bacterial infections. Section A: Infections of the eye and throat. Trachoma and inclusion conjunctivitis
Group A Streptococcus
Diphtheria
Section B: Respiratory tract infections
Bacterial pneumonia
Tuberculosis
Pertussis
Section C: Gastrointestinal tract infections
Helicobacter pylori infection
Escherichia coli diarrhea
Cholera and other vibrios
Shigellosis
Nontyphoid Salmonella disease
Campylobacter infections
Miscellaneous bacterial enteritides
Yersinia enterocolitica
Clostridium infections
Aeromonas
Section D: Sexually transmitted diseases. Chlamydial infections
Lymphogranuloma venereum
Gonorrhea
Chancroid
Granuloma inguinale
Syphilis and the endemic treponematoses
Section E: Infections causing neurologic manifestations. Acute bacterial meningitis
Tetanus
Botulism
Section F: Infections of skin and soft tissues. Bacterial skin and soft tissue infections in the tropics
Leprosy
Buruli ulcer
Mycobacterium marinum infection
Anthrax
Section G: Febrile systemic syndromes with or without lymphadenopathy. Epidemic louse-borne typhus
Murine typhus
Scrub typhus
Tick-borne spotted fever rickettsioses
Rickettsialpox
Q fever
Trench fever
Bartonellosis : Carrion's disease and other bartonella infections
Typhoid and paratyphoid (enteric) fever
Brucellosis
Melioidosis and glanders
Plague
Tularemia
Leptospirosis
Relapsing fever and borrelioses
Part 4: The mycoses. General principles
Superficial mycoses
Subcutaneous mycoses : general principles
Protothecosis
Histoplasmosis
Coccidioidomycosis
Blastomycosis
Paracoccidioidomycosis
Cryptococcosis
Penicilliosis marneffei
Pneumocystis pneumonia
Treatment of systemic mycoses
Part 5: Protozoal infections. General principles
Section A: Intestinal and genital infections
Entamoeba histolytica (amebiasis)
Giardiasis
Cryptosporidiosis
Cyclosporiasis
Cystoisospora belli (syn. Isospora belli )
Miscellaneous intestinal protozoa
Trichomoniasis
Section B: Infections of the blood and reticuloendothelial system. Malaria
African trypanosomiasis
American trypanosomiasis (Chagas disease)
Leishmaniasis
Babesiosis
Section C: Tissue infection. Toxoplasmosis
Pathogenic and opportunistic free-living ameba infections
Sarcocystosis
Microsporidiosis
Part 6: Helminthic infections. General principles
Section A: Intestinal nematode infections. Nematodes limited to the intestinal tract ( Enterobius vermicularis , Trichuris trichiura , Capillaria philippinensis and Trichostrongylus spp.)
Intestinal nematodes: ascariasis
Hookworm and strongyloides infections
Section B: Filarial infections. Lymphatic filariasis
Loiasis
Onchocerciasis
Miscellaneous filariae
Section C: Other tissue nematode infections. Dracunculiasis
Trichinellosis
Toxocariasis
Gnathostomiasis
Eosinophilic meningitis ( Angiostrongylus cantonensis , Parastrongylus cantonensis )
Abdominal angiostrongyliasis
Cutaneous larva migrans
Anisakidosis
Section D: Trematodes infections. Schistosomiasis
Intestinal fluke infections
Liver fluke infections
Paragonimiasis
Section E: Cestode infections. Tapeworm Infections
Larval cestode infections (cysticercosis)
Cystic echinococcosis
Alveolar echinococcosis (alveolar hydatid disease)
Polycystic echinococcosis (polycystic neotropical disease)
Sparganosis
Coenuriasis
Part 7: Poisonous and toxic plants and animals. Animals hazardous to humans: venomous bites, stings and envenoming
Injurious arthropods
Poisonous plants and aquatic animals
Pentastomiasis
Bats
Part 8: Nutritional problems and deficiency diseases. General principles
Protein-energy malnutrition in children
Vitamin deficiencies
Mineral deficiencies
Part 9: Vector transmission of diseases and zoonoses. Section A: Medical entomology. Introduction medical entomology
Section B: Diseases associated with vectors (arthropods in disease transmission). Diseases associated with vectors (arthropods in disease transmission)
Section C: Vector control. Vector control
Part 10: The sick returning traveler. General principles
Fever in the returned traveler
Malaria in the returned traveler
Screening of the asymptomatic long-term traveler
Persistent diarrhea in the returned traveler
Skin lesions in returning travelers
Eosinophilia in migrants and returned travelers: a practical approach
Immigrant medicine
International adoption
Medical tourism
Transplant patients and tropical diseases
Delusional parasitosis
Part 11: Laboratory diagnosis of parasitic diseases. General principles
Preparation of samples for morphologic diagnosis of parasites in stool and urine specimens
Examination of blood, other body fluids, tissues, and sputum
Part 12: Drugs used in tropical medicine. Albendazole
Artemisinin
Benznidazole
Dapsone
DEC
Eflornithine
Ivermectin
Miltefosine
Nifurtimox
Nitazoxanide
Pentamidine
Pentavalent antimony
Praziquantel

Summary: "Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource"--Publisher's description.

Contents:
Section 1: Basic science. Genetics of Huntington disease
Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies
Section 2: Clinical aspects. Epidemiology of Huntington disease
Statistical modelling of Huntington disease onset
The diagnosis and natural history of Huntington's disease
Preclinical cognitive and behavioral changes in Huntington disease
Preclinical motor manifestations of Huntington disease
The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist's role in assessment and counseling
Reproductive options for Huntington disease families
Genetic testing for Huntington disease
Section 3: Treatment of Huntington disease. Medical treatment of behavioral manifestations of Huntington disease
Medical management of motor manifestations of Huntington disease
The role of rehabilitation therapy in Huntington disease
Contemporary health care for Huntington disease
The impact of Huntington disease on young people
Making a measurable difference in advanced Huntington disease care
Section 4: Experimental Therapeutics. New symptomatic therapies for Huntington disease
Motor outcome measures in Huntington disease clinical trials
Cognitive outcome measures in Huntington disease clinical drug trials
Section 5: Biomarkers. Structural imaging in premanifest and manifest Huntington disease
Functional imaging in Huntington disease.