Books

Contents:
1. Engineering lytic polysaccharide monooxygenases (LPMOs) / Zarah Forsberg, Anton A. Stepnov, Guro Kruge Nærdal, Geir Klinkenberg and Vincent G. H. Eijsink
2. Strategies for the expression and characterization of artificial myoglobin-based carbene transferases / Daniela M. Carminati, Eric J. Moore and Rudi Fasan
3. Methods for the detection and analysis of dioxygenase catalyzed dihydroxylation in mutant derived libraries / Julian L. Wissner, Wendy Escobedo-Hinojosa, Peter M. Heinemann, Andreas Hunold and Bernhard Hauer
4. Enhancing promiscuous chemistries of a Schiff-base forming enzyme by divergent evolution / Duncan S. Macdonald and Donald Hilvert
5. Glutamine-walking: Creating reactive substrates for transglutaminase-mediated protein labeling / Lukas Deweid, Adem Hadjabdelhafid-Parisien, Kiana Lafontaine, Léa N.C. Rochet, Harald Kolmar and Joelle N. Pelletier
6. Engineering aldolases for asymmetric synthesis / Mikael Widersten
7. Ultra-high throughput screening for novel protease specificities / Eirini Rousounelou, Steven Schmitt, Luzius Pestalozzi, Martin Held, Tania M. Roberts and Sven Panke
8. Directed evolution of transcriptional switches using dual-selector systems / Yuki Kimura and Daisuke Umeno
9. Methods for competitive enrichment and evaluation of superior DNA ligases / Janine K. Sharma, Luke J. Stevenson, Katherine J. Robins, Adele K. Williamson, Wayne M. Patrick and David F. Ackerley
10. Directed evolution of custom polymerases using droplet microfluidics / Derek Vallejo, Ali Nikoomanzar and John C. Chaput
11. Optically guided mass spectrometry to screen microbial colonies for directed enzyme evolution / Pu Xue, Tong Si and Huimin Zhao
12. Split enzymes: Design principles and strategy / Shion A. Lim and James A. Wells.

Contents:
Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications
Fundaments of Enzyme Kinetics
Different Enzyme Kinetic Models
Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
Multi-Enzyme Kinetics and Sequential Metabolism
Consideration of the Unbound Drug Concentration in Enzyme Kinetics
Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450
Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
Enzyme Kinetics of Conjugative Enzymes : PAPS
Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
Principles and Experimental Considerations for in vitro Transporter Interaction Assays
Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling
The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
Variability in Human in vitro Enzyme Kinetics
Sources of Interindividual Variability
Case Study 1. Practical Considerations with Experimental Design and Interpretation
Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples
Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences.

Contents:
Interlocking enzymes in graphene-coated cellulose paper for increased enzymatic efficiency / Melissa R. Limbacher, Megan K. Puglia, Caterina M. Riccardi, and Challa V. Kumar
Enzyme multilayers on graphene-based FETs for biosensing applications / Christina Bliem, Esteban Piccinini, Wolfgang Knoll, and Omar Azzaroni
Stabilization of laccase through immobilization on functionalized GO-derivatives / Alexandra V. Chatzikonstantinou, Elena Gkantzou, Dimitrios Gournis, Michaela Patila, and Haralambos Stamatis
Synthesis, characterization, and applications of nanographene-armored enzymes / Maryam Khan, Qayyum Husain, and Shamoon Asmat
PAMAM dendrimer modified reduced graphene oxide postfunctionalized by horseradish peroxidase for biosensing H₂O₂ / Sheela Berchmans, Manju Venkatesan, Chirnajeevi Srinivasa Rao Vusa, and Palaniappan Arumugam
Preparation, characterization, and application of enzyme nanoparticles / Neelam Yadav, Jagriti Narang, Anil Kumar Chhillar, and Chandra S. Pundir
Encapsulation of microorganisms, enzymes, and redox mediators in graphene oxide and reduced graphene oxide / Orr Schlesinger and Lital Alfonta
Chemical and biochemical approach to make a perfect biocatalytic system on carbonaceous matrices / Paulina Bolibok, Katarzyna Roszek, and Marek Wiśniewski
Immobilization of a mesophilic lipase on graphene oxide : stability, activity, and reusability insights / Nalok Dutta and Malay K. Saha
A simple flow reactor for continuous synthesis of biographene for enzymology studies / Megan K. Puglia, Murali Anuganti, Yao Lin, and Challa V. Kumar - Enzyme-graphene platforms for electrochemical biosensor design with biomedical applications / Luminita Fritea, Mihaela Tertis, Robert Sandulescu, and Cecilia Cristea
Graphene quantum dots : synthesis and applications / Ankarao Kalluri, Debika Debnath, Bhushan Dharmadhikari, and Prabir Patra
Shielding of enzymes on the surface of graphene-based composite cellular foams through bioinspired mineralization / Yiying Sun, Jingjing Zhao, Jiafu Shi, Shaohua Zhang, and Zhongyi Jiang
Enzyme immobilization on functionalized graphene oxide nanosheets : efficient and robust biocatalysts / Asieh Soozanipour and Asghar Taheri-Kafrani.

Summary: Enzyme Regulation in Metabolic Pathways shows the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Although not the most appropriate means of determining some potential kinetic mechanism, quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots. This book will be a valuable reference for students in biological sciences and biochemistry majors required to take a core course in enzymology.

Contents:
Characteristics of Enzymes
Self-Assembly of Polymers
Beginnings of Equations
Metabolite Distribution Systems
Modification of Enzymatic Activity
Modification of Metabolite Flow Through Metabolic Pathways
Which is the Real Substrate?
Non-Quasi-Equilibrium Assumptions
Underlying Attributes of Assessing Enzymatic Activities
Breakdown of the Michaelis-Menten Equation (or Complex Enzyme Mechanisms)
Rate Equation Derivation by the King-Altman Method
Modification of Enzyme Mechanisms
What Are These "Rate Constants" We Have Been Dealing With?.

Contents:
v. 1. Structure and control
v. 2. Kinetics and mechanics
v. 3. Hydrolysis: peptide bonds
v. 4. Hydrolysis: other C-N bonds, phosphate esters
v. 5. Hydrolysis ... hydration
v. 6. Carboxylation and decarboxylation (nonoxidative) isomerization
v. 7. Elimination and addition, aldol cleavage and condensation
v. 8-9. Group transfers
v. 10. Protein synthesis, DNA synthesis and repair ... v. 11-13. Oxidation-reduction
v. 14-15. Nucleic acids
v. 16. Lipid enzymology: fatty acids, glycerides, phospholipids, sphingolipids, glycolipids, cholesterol, special topics
v. 17-18. Control by phosphorylation
v. 19. Mechanisms of catalysis [pt. 1]
v. 20. Mechanisms of catalysis [pt. 2]
v. 21. Protein lipidation
v. 22. Co- and posttranslational proteolysis of proteins
v. 23. Energy coupling and molecular motors
v. 24. Protein methyltransferases
v. 25. Molecular machines involved in protein transport across cellular membranes
v. 26. Glycosylphosphatidylinositol (GPI) anchoring of proteins
v. 27. Structure, function and regulation of TOR complexes from yeasts to mammals (pt. A)
v. 28. Structure, function and regulation of TOR complexes from yeasts to mammals (pt. B).

Summary: This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed for self-study, it explains how to design enzyme experiments and subsequently analyze the data collected. The book is divided into five major sections: 1] Introduction to enzymes, 2] Practical aspects, 3] Kinetic Mechanisms, 4] Chemical Mechanisms, and 5] Enzymology Frontiers. Individual concepts are treated as stand-alone chapters; readers can explore any single concept with minimal cross-referencing to the rest of the book. Further, complex approaches requiring specialized techniques and involved experimentation (beyond the reach of an average laboratory) are covered in theory with suitable references to guide readers. The book provides students, researchers and academics in the broad area of biology with a sound theoretical and practical knowledge of enzymes. It also caters to those who do not have a practicing enzymologist to teach them the subject.

Contents:
Part I: Enzyme catalysis
a perspective
Enzymes -Their place in Biology
Enzymes
Historical aspects
Exploiting enzymes
Technology
On enzyme nomenclature and classification
Hallmarks of an enzyme catalyst
Origins of enzyme catalytic power
Origins of enzyme catalytic power
Which enzyme uses what trick? Some remarks
Structure and catalysis: Conformational flexibility and protein motion
Part II: Enzyme kinetic practice and measurements
Chemical kinetics
Fundamentals
Concepts of equilibrium and steady-state
ES complex and pre-steady-state kinetics
Principles of enzyme assays
Good kinetic practices
Quantification of catalysis and measures of enzyme purity
Henri-Michaelis-Menten equation
More complex rate expressions
Enzyme kinetic data
Collection and analysis
Part III: Elucidation of Kinetic mechanisms
Approaches to kinetic mechanism
Overview
Analysis of initial velocity patterns
Enzyme inhibition analyses
Irreversible inhibitions
Reversible inhibitions
Alternate substrate (product) interactions
pH Studies with enzymes
Isotopes in enzymology
Isotope exchanges at equilibrium
Isotope effects in enzymology
From kinetic data to mechanism and back
Part IV: Chemical mechanisms and catalysis
Chemical reactivity and molecular interactions
Acid-base chemistry and catalysis
Nucleophilic catalysis and covalent reaction intermediates
Phosphoryl group chemistry and importance of ATP
Enzymatic oxidation-reduction reactions
Carboxylations and decarboxylations
Electrophilic catalysis and amino acid transformations
Integrating kinetic and chemical mechanisms
A synthesis
Part V: Frontiers in enzymology
Regulation of enzyme activity
In vitro versus in vivo
Concept and consequences
Future of enzymology
An appraisal
Closure
Whither Enzymology.

Contents:
Recent advances in development of genetically encoded fluorescent sensors
Engineering rugged field assays to detect hazardous chemicals using spore-based bacterial biosensors
Engineering BRET-sensor proteins
Enzymes as sensors
Integrated strategies to gain a systems-level view of dynamic signaling networks
Probing Cdc42 polarization dynamics in budding yeast using a biosensor
Novel fluorescence-based biosensors incorporating unnatural amino acids
Folding- and dynamics-based electrochemical DNA sensors
Construction of protein-based biosensors using ligand-directed chemistry for detecting analyte binding
Measuring and imaging metal ions with fluorescence-based biosensors: speciation, selectivity, kinetics, and other issues
Bioapplications of electrochemical sensors and biosensors
A highly sensitive biosensor for ATP using a chimeric firefly luciferase
Highly modular bioluminescent sensors for small molecules and proteins
Sensitive protein detection and quantification in paper-based microfluidics for the point of care
Microneedle enzyme sensor arrays for continuous in vivo monitoring
Visualization of the genomic loci that are bound by specific multiprotein complexes by biomolecular fluorescence complementation analysis on Drosophila polytene chromosomes
Author index
Subject index.

Summary: The integration of enzymes in food processing is well known, and dedicated research is continually being pursued to address the global food crisis. This book provides a broad, up-to-date overview of the enzymes used in food technology. It discusses microbial, plant and animal enzymes in the context of their applications in the food sector; process of immobilization; thermal and operational stability; increased product specificity and specific activity; enzyme engineering; implementation of high-throughput techniques; screening of relatively unexplored environments; and development of more efficient enzymes. Offering a comprehensive reference resource on the most progressive field of food technology, this book is of interest to professionals, scientists and academics in the food and biotech industries.

Contents:
Intro; Preface; Contents; Editor;
1: Microbial Enzymes in Food Technology; 1.1 Introduction; 1.2 Enzymes in Food Industry; 1.3 Microbial Enzymes in Food Industries; 1.3.1 Amylases; 1.3.2 Proteases; 1.3.3 Pectinases; 1.3.4 Laccases; 1.3.5 Xylanase; 1.3.6 Lipases; 1.3.7 Lactases; 1.3.8 Cellulases; 1.3.9 Glucose Oxidase and Glucose Isomerase; 1.3.10 Invertase; 1.3.11 Transglutaminase; 1.4 Future Prospects; 1.5 Conclusion; References;
2: Enzymes in Bioconversion and Food Processing; 2.1 Introduction; 2.2 Classification of Enzymes; 2.3 Biochemistry of Enzymes and Their Various Sources 3.1.2.13 Asparagus (Asparagus officinalis)3.1.2.14 Avocado (Persea americana); 3.1.2.15 Banana (Musa acuminata); 3.1.2.16 Beans (Phaseolus vulgaris L.); 3.1.2.17 Broccoli (Brassica oleracea); 3.1.2.18 Cherries (Prunus cerasus); 3.1.2.19 Ginger (Zingiber officinale Roscoe); 3.1.2.20 Garlic (Allium sativum L.); 3.1.2.21 Grapes (Vitis vinifera L.); 3.1.2.22 Mustard (Brassica juncea) and Cabbage (Brassica oleracea); 3.1.3 Food Enzymes in Pharmaceutical Industry; 3.2 Conclusion; References;
4: Enzymatic Browning of Fruit and Vegetables: A Review; 4.1 Introduction; 4.2 Causes of Enzymatic Browning
3: Food Enzymes in Pharmaceutical Industry: Perspectives and Limitations3.1 Introduction; 3.1.1 Significance of Food Enzymes; 3.1.2 Foods As a Source Of Enzymes; 3.1.2.1 Pineapple (Ananas comosus L.); 3.1.2.2 Papaya (Carica papaya L.); 3.1.2.3 FIG (Ficus carica); 3.1.2.4 Kiwifruit (Actinidia deliciosa); 3.1.2.5 Brucea javanica (L.) Merr.; 3.1.2.6 Cluster Fig (Ficus racemosa Roxb.); 3.1.2.7 Pumpkin (Cucurbita maxima); 3.1.2.8 Melon (Cucumis melo); 3.1.2.9 Cucumber (Cucumis sativus); 3.1.2.10 Mango (Mangifera indica); 3.1.2.11 Apple (Malus pumila); 3.1.2.12 Apricot (Prunus armeniaca L.) 4.2.1 Phenolic Compounds4.2.2 Polyphenol Oxidase and Related Enzymes; 4.2.3 Temperature; 4.2.4 pH; 4.3 Mechanism of Enzymatic Browning; 4.4 Control of Enzymatic Browning; 4.4.1 Heating and Cooling; 4.4.2 Heat Shock Method; 4.4.3 High-Pressure Processing; 4.4.4 Chemical Anti-browning Agents; 4.4.5 Other Methods; 4.5 Conclusion; 4.6 Future Perspectives; References;
5: Fungal Inulinases: An Interesting Option for Food Sweetener Production; 5.1 Introduction; 5.2 Action Mechanisms; 5.3 Syrup Production; 5.4 Inulooligosaccharides and Its Application in the Food Industry

Contents:
Section I. Enzyme discovery. Enzyme discovery : enzyme selection and pathway design / Pablo Carbonell, Mathilde Koch, Thomas Duigou, and Jean-Loup Faulon
Section II. Enzyme engineering tools and platforms. Cell-free synthetic biology for pathway prototyping / Ashty S. Karim and Michael C. Jewett ; Fast and flexible synthesis of combinatorial libraries for directed evolution / Joanna C. Sadler, Lucy Green, Neil Swainston, Douglas B. Kell, and Andrew Currin
Section III. Enzyme families : parts and platforms for chemical diversity. Sesquiterpene synthase-catalyzed conversion of a farnesyl diphosphate analogue to a nonnatural terpenoid ether / Florence Huynh, David J. Miller, and Rudolf K. Allemann ; In vivo platforms for terpenoid overproduction and the generation of chemical diversity / Guangkai Bian, Tian Ma, and Tiangang Liu ; Imine reductases, reductive aminases, and amine oxidases for the synthesis of chiral amines : discovery, characterization, and synthetic applications / Sebastian C. Cosgrove, Agata Brzezniak, Scott P. France, Jeremy I. Ramsden, Juan Mangas-Sanchez, Sarah L. Montgomery, Rachel S. Heath, and Nicholas J. Turner ; Experimental protocols for generating focused mutant libraries and screening for thermostable proteins / Max J.L.J. Fürst, Caterina Martin, Nikola Lončar, Marco W. Fraaije ; Characterization of cytochrome P450 enzymes and their applications in synthetic biology / Laura N. Jeffreys, Hazel M. Girvan, Kirsty J. McLean, and Andrew W. Munro
Section IV. Genome engineering for enzyme pathways. Metabolic engineering of Saccharomyces cerevisiae using a trifunctional CRISPR/Cas system for simultaneous gene activation, interference, and deletion / Carl Schultz, Jiazhang Lian, and Huimin Zhao ; YeastFab : high-throughput genetic parts construction, measurement, and pathway engineering in yeast / Eva Garcia-Ruiz, Jamie Auxillos, Tianyi Li, Junbiao Dai, and Yizhi Cai
Section V. Bioengineered strains with designed enzyme pathways. Halomonas and pathway engineering for bioplastics production / Jiang Xiao-Ran, Yin Jin, Chen Xiangbin, and Chen Guo-Qiang ; An engineering approach for rewiring microbial metabolism / Sebastian Wenk, Oren Yishai, Steffen N. Lindner, and Arren Bar-Even ; Multifragment DNA assembly of biochemical pathways via automated ligase cycling reaction / Christopher J. Robinson, Mark S. Dunstan, Neil Swainston, James Titchmarsh, Eriko Takano, Nigel S. Scrutton, and Adrian J. Jervis ; Commodity chemicals from engineered modular type I polyketide synthases / Satoshi Yuzawa, Amin Zargar, Bo Pang, Leonard Katz, and Jay D. Keasling ; Modular pathway rewiring of yeast for amino acid production / Quanli Liu, Tao Yu, Kate Campbell, Jens Nielsen, and Yun Chen.

Contents:
Front Cover; Enzymes of Energy Technology; Copyright; Contents; Contributors; Preface; Chapter One: Purification of fully active and crystallizable photosystem II from thermophilic cyanobacteria;
1. Introduction;
2. Growth and harvest of cells;
3. Isolation of thylakoid membranes;
4. Isolation of crude PSII particles;
5. Purification of PSII dimers;
6. Characterization of the purified PSII core dimers;
7. Crystallization of purified PSII dimers; Acknowledgments; References; Chapter Two: Production and manipulation of blue copper oxidases for technological applications;
1. Introduction
2. Heterologous production of fungal laccases2
.1. Cloning; 2.1
.1. Site-directed mutagenesis; 2.1
.2. Yeast recombination; 2
.2. Transformations; 2.2
.1. S. cerevisiae; 2.2
.2. A. niger; 2
.3. Screening for laccase secreting transformants in S. cerevisiae and A. niger; 2.3
.1. Screening of clones from deep-well or microtiter plate cultures; 2.3
.2. Screening of laccase producing transformants on petri dish plates; 2.3
.3. Screening of activity on 96-well plate; 2.3
.4. ELISA screening; 2
.4. Fermentation in A. niger; 2.4
.1. Preparation of spore inoculum and storage 2.4
.2. Production in bioreactor and growth parameter
s3. General purification procedure and characterization; 3
.1. Purification procedure; 3.1
.1. Assay procedures; 3.1
.2. Laccase purification procedure;
4. Applications; 4
.1. General procedure for an oriented covalent grafting of the laccase surface; 4.1
.1. Preparation of laccase variants for single-site anchoring; 4.1
.2. Reductive amination of lysine; 4.1
.3. Evaluation of the grafting; 4
.2. Hybridization with materials;
5. Conclusions; Acknowledgment; References; Further reading Chapter Three: Production and spectroscopic characterization of lytic polysaccharide monooxygenase
s1. Introduction;
2. Expression and purification of LPMOs; 2
.1. Recombinant expression and purification from the E. coli periplasm; 2
.2. Recombinant expression and purification from the E. coli cytoplasm; 2
.3. Recombinant expression and purification from yeast; 2
.4. Recombinant expression and purification from fungi;
3. EPR spectroscopy; 3
.1. EPR sample preparation for LPMOs; 3
.2. Multifrequency collection; 3
.3. Simulation procedures; Acknowledgments; References; Further reading Chapter Four: A novel overproduction system for the structural determination of a proton-pumping hydrogen-producing [NiFe ..
.1. Introduction; 1
.1. Hydrogen catalysis in nature; 1
.2. Escherichia coli hydrogenase-2 genetic and structural arrangement; 1
.3. First approaches to overexpression of a [NiFe]-hydrogenase;
2. Overproduction of fully formed holo-Hyd-2; 2
.1. Molecular biology strategies for the overproduction of Hyd-2; 2.1
.1. Design of overexpression plasmid pO; 2.1.1
.1. Equipment; 2.1.1
.2. Reagents and buffers; 2.1.1
.3. Procedures; 2.1
.2. Design of overexpression strain HJ001-hyp

Summary: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

Contents:
1. Epicardial Adipose Tissue (EAT) Embriology
2. EAT in Animals
3. EAT Anatomy
4. EAT Bio-molecular Physiology and Pathophysiology
5. EAT Genetic Physiology and Pathophysiology
6. Transcriptome of Epicardial Fat
7. Interaction between Epicardial Fat and Aldosterone-Angiotensin system
8. Epicardial Fat Lipidomics
9. EAT Imaging (Echo, CTA, MRI)
10. EAT Clinical Implications
11. EAT Therapeutic Targets
12. Epicardial Fat and Atrial Fibrillation
13. Neuroendocrine Modulation of Epicardial Fat in Heart Failure and Atrial Fibrillation
14. Perivascular Fat and Atherosclerosis
15. EAT Randomized Controlled Trials
16. Future Directions.

Summary: A physician-anthropologist explores how public health practices--from epidemiological modeling to outbreak containment--help perpetuate global inequities. In Epidemic Illusions, Eugene Richardson, a physician and an anthropologist, contends that public health practices--from epidemiological modeling and outbreak containment to Big Data and causal inference--play an essential role in perpetuating a range of global inequities. Drawing on postcolonial theory, medical anthropology, and critical science studies, Richardson demonstrates the ways in which the flagship discipline of epidemiology has been shaped by the colonial, racist, and patriarchal system that had its inception in 1492.

Contents:
Gramsci, but more pragmatic / Paul Farmer
Part I. Carnivalization
Introduction : Pr [Global health equity | Coloniality]
Colonizer, interrupted (flash fiction)
The allegory of the warren (platonic dialogues)
The pacification of the primitive tribes of Lake Geneva (Nacirema ethnography)
WHO's semiosis (semiotics)
The ebola suspect's dilemma (call and response)
Not-so-big data and immodest causal inference (symbolic reparations)
Ebola vaccines and the ideal speech situation (border gnosis)
The race-PrEP study (counterhegemonic modeling)
The epistemic reformation
Pandemicity, COVID-19, and the limits of public health "science".

Summary: This book comprehensively reviews the 10 most influential epidemics in history, going beyond morbid accounts of symptoms and statistics to tell the often forgotten stories of what made these epidemics so calamitous. The book discusses epidemic disease as a major driving force in shaping our world; brings epidemic diseases out of the background of historical narratives and demonstrates how they have had an immensely important role in deciding wars, toppling empires, sparking major leaps in technology, and even changing the human genome; integrates science with history, sociology, religion, and other disciplines to provide the reader with a unique perspective not found in most other accounts of epidemic disease; shares fascinating insights such as how an epidemic of yellow fever helped to double the size of the United States and why tuberculosis was once considered a disease of the intellectual elite. -- Provided by publisher.

Contents:
Microbes as Agents of Change
Plague
Smallpox
Malaria
Tuberclosis
Typhus
Yellow Fever
Influenza
Polio
HIV/AIDS
Future of Epidemic Disease

Contents:
Introduction
Humoral medicine : the legacy of Hippocrates and Galen
Overview of the three plague pandemics : 541 to ca. 1950
Plague as a disease
Responses to plague
Smallpox before Edward Jenner
The historical impact of smallpox
War and disease : Napoleon, yellow fever, and the Haitian Revolution
War and disease : Napoleon, dysentery, and typhus in Russia, 1812
The Paris School of Medicine
The sanitary movement
The germ theory of disease
Cholera
Tuberculosis in the romantic era of consumption
Tuberculosis in the unromantic era of contagion
The third plague pandemic : Hong Kong and Bombay
Malaria and Sardinia : uses and abuses of history
Polio and the problem of eradication
HIV/AIDS : an introduction and the case of South Africa
HIV/AIDS : the experience of the United States
Emerging and reemerging diseases
Dress rehearsals for the twenty-first century : SARS and Ebola.

Summary: This book analyzes the development of medical big data projects in Japan. Japan is experiencing unprecedented population aging, and labor productivity has decreased accordingly. Big data analysis of the Japanese medical real-world database (RWD) has the potential to tackle this issue. To allow readers to gain an understanding of Japanese medical big data analysis, the book discusses the original Japanese system that generates medical RWDs in the hospital medical records system, the nationwide standardized health checkup system, and the public medical insurance system in Japan. After introducing four major big data projects in the healthcaremedical field in Japan, the book explains the importance of creating information standards to maintain data quality and to analyze medical big data. It enables readers to analyze which standards are installed in which RWDs, how the standards are maintained, and which issues are prevalent in Japan. This book also describes the ethical processes involved in big data projects involving medical RWDs in Japan.

Contents:
Part 1: Diagnosis Procedure Combination (DPC)
Chapter 1. Development of a casemix system and its application in Japan
Part 2: National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB)
Chapter 2. The Present Status and Future Perspective of the National Database of Health Insurance Claim Information and Specified Medical Checkups of Japan (NDB)
Chapter 3. Surveillances for Non-communicable Complex Diseases by National Databases of Health Insurance Claims and Specific Health Checkups of Japan
Chapter 4. Powerful Analytics Platform for National-Scale Database of Health Care Insurance Claims
Chapter 5. Panoramic view of diabetes from a standpoint of the NDB (National Database)
Chapter 6. Nephrology Research in the NDB
Part 3: Medical Information Database Network (MID-NET)
Chapter 7. Drug safety assessment and the Japanese medical information database network (MID-NET)
Chapter 8. A Solution to the Problem of Data Quality in MID-NET
Part 4: Disease Registration Cohort Study with EMR (SS-MIX2)
Chapter 9. Health Information Standards
Chapter 10. SS-MIX structured standardized storage
Chapter 11. Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System (J-DREAMS)
Chapter 12. Japan Chronic Kidney Disease Database: J-CKD-DB
Chapter 13. The Japan Medical Imaging Database (J-MID).

Summary: This book analyzes the development of medical big data projects in Japan. Japan is experiencing unprecedented population aging, and labor productivity has decreased accordingly. Big data analysis of the Japanese medical real-world database (RWD) has the potential to tackle this issue. To allow readers to gain an understanding of Japanese medical big data analysis, the book discusses the original Japanese system that generates medical RWDs in the hospital medical records system, the nationwide standardized health checkup system, and the public medical insurance system in Japan. After introducing four major big data projects in the healthcare–medical field in Japan, the book explains the importance of creating information standards to maintain data quality and to analyze medical big data. It enables readers to analyze which standards are installed in which RWDs, how the standards are maintained, and which issues are prevalent in Japan. This book also describes the ethical processes involved in big data projects involving medical RWDs in Japan.

Contents:
Part 1: Clinical Pathway
Chapter 1. Real World Medical Data Clinical Pathway in Japan
Chapter 2. Medical process analysis by using all-variance type outcome-oriented electronic clinical pathway data -Exploratory extracting critical indicator
Chapter 3. Information and Data standard development for Clinical Pathways
Part 2: Standard Code Mapping and Data Quality
Chapter 4. Japan Laboratory Code (JLAC) 10
Chapter 5. ICD-10 and ICD-11 in Japan
Chapter 6. Standard codes for prescribing drugs use multiple code systems depending on their purpose
Chapter 7. Data Quality Governance Experience at the MID-NET Project
Part 3: Phenotyping
Chapter 8. Phenotyping in Japan
Chapter 9. Phenotyping of Administrative Claims Data
Chapter 10. Phenotyping study using MID-NET database
Chapter 11. Integration of phenotyping algorithms in Japan
Part 4: Data Analysis on Real World Data
Chapter 12. Analysis on Real-World Data: An Overview
Chapter 13. Problems in Japanese real-world medical data analyses
Part 5: Ethical Issues of Data Secondary Use in Japan
Chapter 14. Ethical, Legal, and Social Issues Pertaining to the Use of Real-world Health Data in Japan
Chapter 15. The Next-Generation Medical Infrastructure Law.

Summary: Written for those who are familiar with the basic strategies of analytic epidemiology, This fourth edition takes readers through a rigorous discussion of key epidemiologic concepts and methods such as study design, measures of association, research assessment, and more. With real-life examples throughout, the book avoids complex statistical formulations and is an invaluable resource for intermediate students and practicing epidemiologists who wish to expand their knowledge of epidemiology and its role in the medical and public health sciences.

Contents:
Basic study designs in analytical epidemiology
Measuring disease occurrence
Measuring associations between exposures and outcomes
Understanding lack of validity : bias
Identifying noncausal associations : confounding
Defining and assessing heterogeneity of effects : interaction
Stratification and adjustment : multivariate analysis in epidemiology
Quality assurance and control
Communicating results of epidemiologic studies
Epidemiologic issues in the interface with public health policy.

Contents:
pt. I.
1. The Doctrine of contagion
2. Modern theories, analysis of
3. The Propagation of cholera
4. Epizootics, or, Disease in the brute creation
pt. II. Will shortly be issued, and will embrance the following subjects
5. The Remote cause of epidemic diseases in the animal creation
6. The Cause of blight and pestilence in the vegetable creation
7. The Cause of hurricanes, and abnormal atmospherical vicissitudes
8. Historical pathology, or a Brief history of the pestilences, murrains and blights, with the aberrations in the material world that have been observed during historical periods.

Summary: Endorsed by the Australasian College for Infection Prevention and Control (ACIPC) ACIPC is the peak body for infection prevention and control professionals in the Australasian region. Healthcare-associated Infections (HAIs) are a major threat to patient safety and the quality of healthcare globally. Despite this, Australia does not have a nationally coordinated program for the surveillance and reporting of HAIs. Epidemiology of Healthcare-associated Infections in Australia is Australia's first peer-reviewed, evidence-based assessment of the epidemiology of HAIs using publicly available data from hospital-acquired complications (HACs), state-based surveillance systems and peer-reviewed and grey literature sources. This important work has been compiled by some of Australia's leading infection control professionals and researchers. It will build national consensus on definitions, surveillance methodology and reporting of the incidence of HAIs. In doing so, it provides hospitals and those working in infection prevention and control an opportunity to benchmark and evaluate interventions to reduce infections and ensure transparency on reporting methods that will strengthen Australia's efforts to prevent and control HAIs. Here is a great article published in Sydney Morning Herald on the publication of Epidemiology of Healthcare-associated infections in Australia. Collated publicly available HAI surveillance definitions from jurisdictions across Australia Collated publicly available national HACs HAI data derived from the associated surveillance programs Identification of the gaps in both publicly available HAI data from different sources and the lack of publicly available HAI surveillance data in one serialised title Supporting video summarising key content Available in eBook format with print-on-demand option.

Contents:
Executive summary
Surgical site infection
Urinary tract infection
Pneumonia
Bloodstream infection
Central line and peripheral line-associated bloodstream infection
Multi-resistant organisms
Infection associated with prosthetics and implantable devices
Gastrointestnial infection.

Summary: Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest.

Contents:
A Short History of Birth Defect Epidemiology
Genetic and Non-genetic Factors in the Origin of Congenital Malformations
Ascertainment of Children with Congenital Malformations
Statistical Considerations
Epidemiological Methods
Neural Tube Defects
Microcephaly
Hydrocephaly
Agenesis of Corpus Callosum and Holoprosencephaly
Severe Eye Malformations
Severe Ear Malformations
Cardiovascular Defects
Orofacial Clefts
Atresia or Stenosis of the Alimentary Tract
Pyloric Stenosis
Malrotation of the Gut
Megacolon
Hypospadias
Epispadias, Cloacal and Bladder Exstrophy
Severe Renal Malformations
Posterior Urethral Valve
Pes Equinovarus
Other Foot Deformities than Pes Equinovarus
Polydactyly and Syndactyly
Limb Reduction Defects
Craniostenosis
Diaphragmatic Hernia
Abdominal Wall Defects
Children with multiple malformations
Syndromes
Down Syndrome
Explanation and Prevention of Birth Defects
Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies.

Summary: This concise yet comprehensive book covers epidemiology of injuries in 24 different sports ranging from football, volleyball, athletics, to less explored ones, like archery and Formula 1. For each discipline the authors present and analyze the sport's main characteristics, physiological and biomechanical demands on athletes, epidemiology of injuries, prevention strategies, rehabilitation and return to play. Based on an updated overview of sport specific data, this book equips the reader with a solid understanding of sports injury epidemiology and its importance for the implementation of preventive measures. Written in collaboration with ESSKA by almost 100 international experts, sharing the belief that prevention is the first mission of sports medicine, this book is an excellent source of knowledge for sports physicians, researchers, residents, fellows and trainers alike.

Contents:
1 Archery
2 Athletics: jumping disciplines
3 Long-distance running
4 Athletics: sprint disciplines
5 Throwing athletes
6 Basketball
7 Cycling
8 Extreme Sports
9. Field Hockey
10 Football
11 Youth Football
12 Handball
13 Ice Hockey
14 Olympics
15 F 1
16 Motocross.-17 Rugby
18 Ski
19 Alpine Ski.-20 Cross Country Skiing
21 Tennis.-22 Volleyball
23 Waterpolo
24 Wrestling.

Contents:
Differentiation of Human Induced Pluripotent Stem Cells into a Keratinocyte Lineage / Igor Kogut, Dennis R. Roop, and Ganna Bilousova
Differentiation of Epidermal Keratinocytes from Human Embryonic Stem Cells / Fahad K. Kidwai, Tong Cao, and Kai Lu
Protocol for Serial Cultivation of Epithelial Cells Without Enzymes or Chemical Compounds / Dongxia Ye and Antonio Peramo
Growth and Differentiation of HaCaT Keratinocytes / Van G. Wilson
Transgene Delivery to Cultured Keratinocytes Via Replication-Deficient Adenovirus Vectors / Vincent P. Ramirez and Brian J. Aneskievich
Analyzing the Global Chromatin Structure of Keratinocytes by MNase-Seq / Jason M. Rizzo and Satrajit Sinha
Analysis and Meta-Analysis of Transcriptional Profiling in Human Epidermis / Claudia Mimoso, Ding-Dar Lee, Jiri Zavadil, Marjana Tomic-Canic, and Miroslav Blumenberg
Compound Screening and Transcriptional Profiling in Human Primary Keratinocytes: A Brief Guideline / Raphaela Rid, Harald Hundsberger, and Kamil Önder
Preparation of Primary Cultures of Mouse Epidermal Keratinocytes and the Measurement of Phospholipase D Activity / Lakiea J. Bailey, Vivek Choudhary, Purnima Merai, and Wendy B. Bollag
Lipid Rafts and Detergent-Resistant Membranes in Epithelial Keratinocytes / Kathleen P. McGuinn and Mỹ G. Mahoney
MMP-2, 9 and TIMP-1, 2 Assays in Keratinocyte Cultures / Takashi Kobayashi
Reactive Oxygen Species (ROS) Protection Via Cysteine Oxidation in the Epidermal Cornified Cell Envelope / Wilbert P. Vermeij and Claude Backendorf
Modified Methods for Growing 3-D Skin Equivalents: An Update / Rebecca Lamb and Carrie A. Ambler
A Novel Three-Dimensional Cell Culture Method to Analyze Epidermal Cell Differentiation In Vitro / Yoji Okugawa and Yohei Hirai
Reconstruction of Normal and Pathological Human Epidermis on Polycarbonate Filter / Evelyne De Vuyst, Céline Charlier, Séverine Giltaire, Valérie De Glas, Catherine Lambert de Rouvroit, and Yves Poumay
Methods for the Preparation of an Autologous Serum-Free Cultured Epidermis and for Autografting Applications / John J. Wille, Jeremy J. Burdge, and Jong Y. Park
Human Keratinocyte Cultures in the Investigation of Early Steps of Human Papillomavirus Infection / Laura M. Griffin, Louis Cicchini, Tao Xu, and Dohun Pyeon
Preparation and Delivery of 4-Hydroxy-Tamoxifen for Clonal and Polyclonal Labeling of Cells of the Surface Ectoderm, Skin, and Hair Follicle / Christine Chevalier, Jean-François Nicolas, and Anne-Cécile Petit
Microdissection and Visualization of Individual Hair Follicles for Lineage Tracing Studies / Inês Sequeira, Emilie Legué, Suzanne Capgras, and Jean-François Nicolas
Isolation and Characterization of a Stem Cell Side-Population from Mouse Hair Follicles / Paula L. Miliani de Marval, Sun Hye Kim, and Marcelo L. Rodriguez Puebla
Multi-Scale Mathematical Modeling and Simulation of Cellular Dynamical Process / Shinji Nakaoka
Erratum.

Summary: This book offers an in-depth examination of labor pain and analgesia with the aim of promoting natural childbirth without pain. All aspects of the subject are covered, including the latest techniques of delivering labor analgesia. Importantly, emphasis is placed on a holistic approach, detailed attention being paid to the humanization of childbirth and behavioral aspects in addition to evidence-based medicine. Potential future developments are also addressed, with discussion of opportunities that have yet to be realized. In order to ensure that the text is easily readable for trainees as well as established practitioners, chapters have been restricted to a manageable length and information is presented clearly and succinctly. Step-by-step tutorials and boxes highlighting practical points are used to clarify technical aspects. The authors include both well-established experts and young emerging professionals from various European countries, ensuring an intercultural perspective.

Contents:
Physiology of labor
Anatomo-physiological changes during labor and after delivery
Labor pain
Sociology of labor pain
History of labor pain relief
Antenatal consultation, maternal information, expectations and satisfaction
Initiation of labor analgesia: epidural, CSE
Maintenance of labor analgesia
Analgesia during second & third stage, episiotomy, episiotomy repair
Maternal and fetal monitoring during neuraxial labor analgesia
Nutrition and fluid balance during labor; maternal optimization and fetal resuscitation
Analgesia for dystocia and instrumental delivery
Analgesia for induced labor and vaginal birth after cesarean section
Extension of epidural block for cesarean section
Postpartum analgesia and postpartum chronic pain
Effects on neonate and breastfeeding
Neonatal care in labor and delivery room
Technical problems and their solutions
Anti-coagulated parturient and neuraxial analgesia
Complications of neuraxial analgesia
Evidence based medicine and labor analgesia
Ethics
Teaching labor analgesia and simulation
Humanization of labor and epidural analgesia
Medico-legal issues in labor analgesia.

Summary: This book represents a unique and substantial guide, and will bring anesthesiologists up-to-date on advances in the neuraxial technique and its applications in obstetrics. Today the epidural block is almost exclusively of interest to obstetric anesthesiologists, and how it is taught increasingly coincides with its applications in obstetrics. Since the classical, seminal textbooks by Bonica, Moore and Bromage, published in the 1950s and 60s, textbooks devoted solely to the epidural technique have become quite rare. Among more recent books, there are many excellent texts on epidural anesthesia or analgesia in obstetrics, but none are fully dedicated to the epidural technique, which is usually described in a few paragraphs or, at most, in a chapter. This highly detailed book, including videoclip on epidural technique, offers comprehensive coverage on epidurals; as such, it will appeal to all anesthesiologists, especially obstetric anesthesiologists.

Contents:
Intro
Preface
Contents
1: History of Lumbar Epidural Block
1.1 Was the Very First a Spinal or an Epidural Anesthesia?
1.2 The First Epidural Approach: The Caudal
1.3 Lumbar Epidural
1.4 Continuous Lumbar Epidural
1.5 Modern Epidural Analgesia
References
2: Anatomy of the Lumbar Epidural Region
2.1 Vertebral Column
2.2 Lumbar Vertebra
2.3 Ligamentum Flavum
2.4 Interspinous and Supraspinous Ligaments
2.5 Muscles
2.6 Intervertebral Foramen and Its Ligaments
2.7 Epidural Space
2.7.1 Epidural Fat 2.7.2 Nerve Roots and Nerve Root Cuff
2.7.3 Internal Vertebral Venous Plexus, Epidural Arteries, and Lymphatics
2.8 Dural Sac
2.8.1 Dura Mater
2.8.2 Arachnoid Layer
2.8.3 Subdural and Intradural Space
References
3: Distribution of a Solution in the Epidural Space
3.1 Sites of Action, Dynamics of Nerve Block, and Physicochemical Properties of Local Anesthetics
3.2 Local Tissue Distribution
3.3 Absorption and Elimination
3.4 Spread of a Solution in the Epidural Space
3.4.1 Patient Characteristics
3.4.1.1 Age 3.4.1.2 Height, Weight, and Body Mass Index
3.4.1.3 Pregnancy
3.4.2 Technical Factors
3.4.2.1 Needle Insertion Site, Bevel Orientation and Injection Through Needle or Through Catheter, Needle Bevel Direction, and Catheter Position
3.4.2.2 Patient Position
3.4.2.3 Epidural Catheter Design
3.4.2.4 Mode of Administration of the Solution
3.4.2.5 Speed of Injection
3.4.3 Epidural Pressure and Adjacent Pressures
3.4.4 Composition of the Solution Injected: Dose, Volume, and Concentration-Adjuvant Drugs
References
4: Fundamentals
4.1 Epidural Equipment 4.1.1 Epidural Needles
4.1.2 Epidural Syringes
4.1.3 Epidural Devices
4.1.4 Epidural Catheters
4.1.5 Epidural Filters
4.1.6 Connectors
4.2 Patient Position
4.2.1 Positioning the Patient
4.3 Landmarks Identification
4.3.1 Manual Palpation
4.3.2 Ultrasound Identification
4.4 Skin Disinfection
4.5 Superficial Tissues' Local Anesthesia
4.5.1 Technique
References
5: Epidural Technique
5.1 Loss-of-Resistance-to-Saline Technique
5.2 False or Pseudo-Loss of Resistance
5.3 Bone Contact
5.4 Observation and Aspiration of the Needle 5.5 Rebound Test and Partially Inserted Bevel of the Needle in the Epidural Space
5.6 Loss of Resistance to Air
5.7 Techniques Based on Epidural Negative Pressure
5.8 Paramedian Approach
5.9 Forces Involved During Needle Insertion
5.10 Catheter Insertion, Needle Removal, and Catheter Fixation
5.11 Catheter Aspiration and Test Dose
5.12 Confirmation of Catheter Location in the Epidural Space
5.12.1 Epidural Stimulation Test
5.12.2 Epidural Pressure Waveform Analysis
Appendix 1: Epidural Technique in Five Steps

Summary: Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Summary: The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chimeric, leukemia-specific transcription factors. This book first presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

Contents:
The fundamental role of epigenetic regulation for normal and disturbed all growth and differentiation
Mouse models to study DNA methylation in cancer research
Epigenetic regulation of normal hematopoietic development
Epigenetic regulation of globin genes and disturbances in hemoglobinopathies
DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches
Epigenetic modifications mediated by the AML1/ETO and MLL leukemia fusion proteins
Epigenetic abnormalities in lung cancer
Pharmacodynamic Responses to DNA Methyltransferase Inhibition
Histone Methyltransferases: Opportunities in Cancer Drug Discovery
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
Clinical Implications of Epigenetic Alterations in Lung Cancer
Epigenetic disturbances in colorectal cancer
Epigenetic Therapies in Solid Tumours: from preclinical models to clinical trial results.

Contents:
1. Epigenetics and Cancer
2. Epigenetics, Enhancers, and Cancer
3. Early Life: Epigenetic Effects on Obesity, Diabetes, and Cancer
4. Nutritional and Lifestyle Impact on Epigenetics and Cancer
5. Environmentally Induced Alterations in the Epigenome Affecting Obesity and Cancer in Minority Populations
6. Stress, Exercise, and Epigenetic Modulation of Cancer
7. Epigenetic Effects of Gut Microbiota on Obesity and Gastrointestinal Cancers
8. Epigenetics in Obesity and Esophageal Cancer
9. Epigenetics, Obesity, and Colon Cancer
10. Energy Balance, Epigenetics, and Prostate Cancer
11. Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer
Index.

Contents:
Epigenetics and Development: A Natural Process
Cause and Effect in Epigenetic Disease Epidemiology
Epigenetics and Health
Molecular Basis of Epigenetics
Trans-generational Epigenetics
Maternal Exposure to Pharmaceuticals
Maternal Exposure to Poor Nutrition
Maternal Exposure to Alcohol, Tobacco, and Drugs
Maternal Exposure to Lead and Mercury
Maternal Exposure to Stress
Paternal Exposure to Environmental Mutagens and Stressors
Protective Nutrition Before and During Pregnancy
Protective Behaviors Before and During Pregnancy
Impact of Dental Mercury on Lifespan Health
Children's Exposure to Stress
Children's Exposure to Lead and Mercury
Children's Exposure to Alcohol, Tobacco, and Drugs
Children's Exposure to Violence
Children's Exposure to Traumatic Events
Children's Exposure to Poor Nutrition
Infection Impact on Child Development and Epigenetics
HLA and Immune Response
Allostatic Load
Latent Periods and Cardiovascular/Cancer Risks
Dynamics of Life Experiences on Polygenic Gene Regulation
Food Chain Impact of Pesticides on Human Health
Sun and Artificial Radiation Exposure on Skin Health
Medical Imaging Radiation Risk on Health
Naturopathic Approaches to Epigenetic Health
Reprogramming Epigenetic Effects
An Ecological Systems Approach to Epigenetic Health
The Health Leader's Guide to Promoting Epigenetic Health .

Summary: This book helps transform the awareness of the anticipatory perspective into actionable methods for practitioners of medicine. It provides guidance for those who design new means and methods inspired by epigenetics, in particular to those who advance sustainable alternatives.

Contents:
Context : A Subject More Important Than Ever
DNA Methylation as an Epigenetic Mechanism of Anticipation
The Genetics and Epigenetics of Anticipatory Adaptation.

Summary: This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts - the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Contents:
Epigenetics in health and disease
The development of epigenetics in the study of disease pathogenesis
Epigenetic methods and twin studies
The role of genetics, the environment and epigenetics in atopic dermatitis
The epigenetics of food allergy
Epigenetics and the Environment in allergy and asthma: asthma and allergic rhinitis
Epigenetics of lupus erythematosus
Epigenetics of psoriasis
The role of epigenetics in type 1 diabetes
Epigenetics of Primary Biliary Cholangitis
Epigenetics in primary Sjogrens syndrome
Epigenetics in Multiple Sclerosis
The epigenetic regulation of Scleroderma and its clinical application.

Summary: Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants' epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.

Contents:
Chapter 1
The role of small RNAs in plant somatic embryogenesis.- Chapter 2
Past, present and future: plant epigenetic memory.- Chapter 3
Casein kinase-mediated histone phosphorylation in model plants and crops.- Chapter 4
Epigenetics in light regulation of plant development.- Chapter 5
Canonical histones and their variants in plants: evolution and functions.- Chapter 6
Plant epigenetic mechanisms in response to biotic stress.- Chapter 7
Targeted epigenome editing for activation of plant defenses.- Chapter 8
Epigenetics in crop biotechnology.- Chapter 9
The Role of Germinally Inherited Epialleles in Plant Breeding.- Chapter 10
Epigenetics and Heterosis in Crop Plants.- Chapter 11
Epigenetic Variation Amongst Polyploidy Crop Species.- Chapter 12
Histone H3 Phosphorylation in Plants and Other Organisms.- Chapter 13
Tomato Epigenetics: Deciphering the 'Beyond' Genetic Information in a Vegetable Fleshy-Fruited Crop.- Chapter 14
Epigenetic Advances on Somatic Embryogenesis of Agronomical and Important Crops.- Chapter 15
MicroRNA Expression and Regulation During Plant Somatic Embryogenesis.- Chapter 16
Can Epigenetics Help Forest Plants to Adapt to Climate Change?.- Index.

Summary: "A concise clinical reference to the important features of epilepsy, providing a comprehensive grounding of basic knowledge that lays the foundation for effective care of persons with seizures. It guides practitioners in thinking logically about treatment, from the first clinic visit, subsequent visits, treatment failure, adverse effects, pregnancy, seizure emergencies, etc. The target audience is neurology residents, but this approach should prove useful for epilepsy fellows and for practitioners"-- Provided by publisher.

Contents:
I. Epilepsy: Epidemiology, Diagnostic evaluation and Co-Morbidities (Greg Cascino)
Chapter 1. Introduction and Epidemiology (Cascino)
Chapter 2. Classification of Seizures and the Epilepsies (Wirrell)
Chapter 3. Etiology and Pathology (Noe, Nickels)
Chapter 4. Genetics of Epilepsy (Fine, Wong-Kisiel, Sheth)
Chapter 5. Burden of Epilepsy (co-morbidities, driving, SUDEP, disability, psychiatry, IEPs, Quality Care in Epilepsy) (Crepeau, Cascino, Moore)
Chapter 6. EEG and Epilepsy (include routine, scalp-recorded video-EEG, MEG) (Feyissa, Lagerlund, So)
Chapter 7. Neuroimaging in Epilepsy (include CT, MRI, PET, SISCOM, fMRI) (So, Kotsenas, Watson, Brinkmann)
Chapter 8. Diagnosing Epilepsy versus other Events- Non-epileptic spells (Drazkowski, Hoerth)
Chapter 9. Sleep disorders and epilepsy (St. Louis, Carvalho, Moore)
Epilepsy Journey # 1: Patient with a Genetic based epilepsy-what does this mean and how to counsel (Fine) ; Epilepsy Journey # 2: Patient with Spells- Algorithm for Spell workup- Adult (older pt.) Burkholder ; Epilepsy Journey # 3: Patient with Spells- Algorithm for Spell Workup- Kid (Nickels) ; Epilepsy Journey #4: Transitioning from pediatric to adult epilepsy clinic (Cascino, Nickels)
II. Epilepsy: Treatment of Epilepsy: Non-surgical therapy (Joe Sirven)
Chapter 10. First seizure (Spritzer, Shin )
Chapter 11. Antiepileptic drug therapy (Britton)
Chapter 12. Women's Issues in Epilepsy (Noe)
Chapter 13. Treating Children with Epilepsy AEDs (Sheth)
Chapter 14. Diet therapy (LGID, ketogenic diet) (Nickels, Wirrell)
Chapter 15. Autoimmune Epilepsy (evaluation and treatment) (Britton, Pittock, McKeon, Flanagan)
Chapter 16. Discontinuation of AED therapy (Britton)
Chapter 17. Investigational therapy and drug approval process in US (including Cannabidiol) (Cascino, Sirven)
Chapter 18. Devices to Monitor and Track your Epilepsy (Smart Watch, Embrace, etc.) (Crepeau)
Epilepsy Journey # 5: Seizure Emergencies (include status epilepticus, FIRES, NORSE, Seizure First Aid, and Seizure Clusters) (Feyissa, Hoerth, Payne) ; Epilepsy Journey # 6:The First seizure- How to Evaluate and workup- Pediatric- (Williams) ; Epilepsy Journey # 7: The First seizure-How to evaluate and workup- Adult (Sirven) ; Epilepsy Journey # 8: Treating Epilepsy Second seizure and Beyond-How to Choose a Drug- Analgorithm (Crepeau) ; Epilepsy Journey # 9: Treating Status Epilepticus- An Algorithm (Hocker, Payne) ; Epilepsy Journey # 10: Withdrawing an AED Drug in Adults- An Algorithm (Sirven) ; Epilepsy Journey # 11: Withdrawing an AED Drug in Kids- An Algorithm (Wirrell) ; Epilepsy Journey # 12: Withdrawal of ASDs after Epilepsy SurgeryEpilepsy Journey # 13: The Pregnant Patient- An algorithm (Noe)
III. Epilepsy: Treatment of Epilepsy: Surgical management (Bill Tatum)
Chapter 19. Presurgical evaluation (candidate selection, phase 1, surgically remediable epilepsy syndromes)- (Burkholder, Meyer, Ritaccio, Shin)
Chapter 20. Minimally Invasive epilepsy surgery (Electrocoagulation, Gamma Knife, Laser Interstitial Thermal Therapy)-(Tatum, Grewal, Wharen)
Chapter 21. Intracranial EEG monitoring (electrode selection for iEEG, SEEG, ECoG)-(Van Gompel, Noe, Zimmerman)
Chapter 22. Surgical strategies (include cortical resection, lesionectomy, cortical stimulation and functional mapping, hemispherotomy)- (Marsh, Chaichana, Zimmerman, Quinones)
Chapter 23. Disconnection surgeries (epilepsy surgery in neonates/infants, corpus callosotomy, MST)- (Wirrell, Wong-Kisiel, Miller)
Chapter 24. Neuromodulation (VNS, DBS, RNS) Surgical Outcome (seizure-free, quality of life, AED therapy)-( Lundstrom, Wharen, Tatum)
Chapter 25. Emerging surgical procedures in epilepsy -(Lundstrom, Worrell, Stead)
Chapter 26. Seizure Forecasting (Neurovista, iEEG, software algorithms)-(Brinkman, Worrell) Epilepsy Journey # 14: The drug-resistant patient- presurgical evaluation and surgery-approach to the "skip" candidate (Feyissa, Burkholder) ; Epilepsy Journey # 15: The drug-resistant patient and discordant presurgical evaluation- an algorithm for intracranial EEG-(Wong-Kisiel, So, Zimmerman) : Epilepsy Journey # 16: The drug-resistant patient who is not a candidate for resective surgery-an algorithm for neuromodulation (Ritaccio, Tatum) : Epilepsy Journey # 17: Pediatric patients and epilepsy surgery-an algorithm for treatment (Sheth, Miller, Wirrell IV). Conclusion (all editors) --

Contents:
1. Introduction
2. Epilepsy: a general overview
3. Epidemiology of epilepsy in persons with intellectual disabilities
4. Diagnosis of epilepsy in persons with intellectual disabilities
5. The differential diagnosis of epilepsy
6. Management of acute seizures in persons with intellectual disabilities
7. The use of antiepileptic medication in adults with intellectual disabilities: a serious conundrum
8. Vagus nerve stimulation therapy: an intellectual disabilities perspective
9. Resective surgery for patients with epilepsy and intellectual disabilities
10. Nonpharmacological management of epilepsy in adults with intellectual disabilities
11. Psychopathology in people with epilepsy and intellectual disabilities
12. Associated physical problems in epilepsy in intellectual disabilities
13. Epilepsy and cognition
14. Nursing and community aspects of epilepsy in intellectual disabilities
15. Impact of epilepsy and intellectual disabilities on family life
16. Epilogue: death and love in epilepsy
Index.

Contents:
Ch. 1: Physiologic Basis of EEG and Epilepsy
Ch. 2: EEG instrumentation, Montage, Polarity, and Localization
Ch. 3: Normal EEG Variants and Artifacts
Ch. 4: Neonatal EEG and Neonatal Seizures
Ch. 5: MCQ
Ch. 6: Ictal and Interictal EEG
Ch. 7: EEG and Semiology in Generalized Epilepsies
Ch. 8: EEG and Semiology in Focal Epilepsy
Ch. 9: Status Epilepticus
Ch. 10: EEG in Encephalopathy and Coma
Ch. 11: MCQ
Ch. 12: Electro-clinical Syndromes by Age of Onset
Childhood, Adolescence-adult
Ch. 13: Seizures and Epilepsy in Early Life
Ch. 14: Imitators of Epilepsy
Ch. 15: Genetic Analysis of Epilepsies
Ch. 16: Epilepsy Secondary to Specific Mechanisms
Ch. 17: MCQ
Ch. 18: Principles of Epilepsy Diagnosis and Management
Ch. 19: Old Generation Antiepileptic Drugs
Ch. 20: New Generation Antiepileptic Drugs
Ch. 21: Dietary Therapies
Ch. 22: Other Pharmacological Therapies: Investigational Antiepileptic Drugs, Animal Models of Epilepsy, Hormonal Therapy, Immunotherapy
Ch. 23: Epilepsy Management in Special Populations
Ch. 24: MCQ
Ch. 25: Neuroimaging in Epilepsy
Ch. 26: Neuropsychological Evaluation in Epilepsy
Ch. 27: Magnetoencephalography and magnetic source modeling
Ch. 28: Vagus Nerve Stimulation and other Neuromodulation
Ch. 29: Epilepsy surgery assessment and testing
Ch. 30: Procedures and outcomes in epilepsy surgery
Ch. 31: Quality of Life in Epilepsy
Ch. 32: MCQ.

Summary: This book presents scientific evidence about epilepsy along with straightforward guidance and recommendations. Responses to frequently asked questions and clarification of uncertainties are provided to empower patients to optimize their medical, psychological and social care. This book helps mediate between patients and health care professionals and can assist both sides to understand the condition of epilepsy at all levels. The information provided in the book empowers patients to share decision making with their carers and clinicians and enables them to make informed decisions, by taking into account the best scientific evidence, as well as the patients' values and preferences. The Epilepsy Book: A Companion for Patients  is ideal for patients with epilepsy and their carers, and will also be of interest to health care professionals, medical students and teachers. Thalia Valeta's approach to epilepsy facilitates deeper understanding of the unmet needs and expectations of patients.

Contents:
History of epilepsy
General Aspects of Epilepsy
Preparing for the medical consultation
Epileptic seizures
Febrile seizures
Reflex seizures
Epileptic syndromes and their classification
Idiopathic generalized epilepsies
Benign childhood focal epilepsy
Epileptic encephalopathies
Structural (symptomatic) focal epilepsy
Women and epilepsy
Mortality and sudden unexpected death in epilepsy (SUDEP)
Investigations for epileptic seizures
Prophylactic treatment with antiepileptic drugs
Comorbidities in epilepsy
Psychogenic non-epileptic seizures
Psychological treatments for epilepsy
''Metamyth''©/Dramatherapy
Complementary (alternative) treatments for epilepsy
Dietary treatments for epilepsy and ketogenic diet
Safety in epilepsy
Psychosocial impact of epilepsy
Psychosocial aspects- parental reactions and needs in idiopathic focal epilepsies
Stigma in epilepsy and how to combat it
Websites and other resources for people with epilepsy.

Summary: Written by expert epilepsy clinicians from the Mayo Clinic, Epilepsy Case Studies: Pearls for Patient Care presents a wide variety of case histories drawn from real life experiences in people with seizures. Designed to stimulate the same deductive reasoning that is commonly used when seeing epilepsy patients in the clinic, this practical book presents the clinical scenario and then poses a range of stimulating questions to organize the reader's thoughts to address each case. Questions that revolve around each case include common ones such as "How does this test help us with the diagnosis" and "What is the precise relationship of the patient's seizures to their overall neurological condition". The most poignant questions include "How does this information help us to devise a treatment plan?" and "What do we know about the anticipated course and prognosis?" The questions raised in each section incorporate the clinical course and evaluation. Where possible, the discussion relies upon the latest medical evidence to support the responses and includes up-to-date techniques used for patients with and without seizure control. At the end of each case a few salient citations are referenced, as are a few of the more pertinent articles that the reader can reference to obtain an overview of the topic.

Summary: This book presents a case based approach to epilepsy management in both diagnostic challenges and treatment of complex cases. Cases reflect "real life" patient scenarios that practitioners encounter with up-to-date terminology and treatment approaches. With 51 chapters, the book presents 51 unique, nuanced cases. Beginning with an initial presentation of a case history, the book opens with a basis for drawing in multiple aspects in the treatment of patients with epilepsy. Each chapter is organized into a clinical history, physical examination results, and ancillary testing to concentrate on differential diagnosis and focus on a definitive procedural approach to the final diagnosis. Subsequent information about the condition expands on the knowledge of the clinical features to a solution of common patient clinical scenarios as it affects people with epilepsy. A comprehensive successor edition, Epilepsy Case Studies is an invaluable resource to clinicians ranging from those looking for a quick review of a topic present in the table of contents, to those crossing disciplines into medical areas where seizures are a symptom of disordered or dysfunctional brain

Contents:
Acetazolamide
ACTH
Brivaracetam
Carbamazapine
Clobazam
Clonazepam
Diazepam
Eslicarbazepine acetate
Ethosuximide
Felbamate
Fosphenytoin
Gabapentin
Lacosamide
Lamotrigine
Levetiracetam
Lorazepam
Methsuximide
Midazolam
Oxcarbaepine
Paraldehyde
Perampanel
Phenobarbital
Phenytoin
Piracetam
Pregabalin
Primidone
Rufinamide
Stiripentol
Sulthiame
Tiagabine
Topiramate
Valproate
Vigabatrin
Zonisamide.

Summary: "This practical and concise book is an essential reference guide for use by all clinicians and allied health professionals that treat or care for patients with epilepsy. In full color throughout, this volume presents the antiepileptic drugs (AEDs), 34 in total, in alphabetical order and for each AED the information is divided into eight colored sections: general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special populations, overview, and suggested reading. This second edition has been extensively revised and updated. Specific additions include: inclusion of the new drugs perampanel and retigabine (also called ezogabine), updated pharmacokinetic interactions, suggested pediatric dosing schedules for several drugs, discussion about bone health and vitamin D monitoring and supplementation, information on teratogenicity in the sections on pregnancy. This handy pocket book will be an excellent companion for all clinicians that treat patients with epilepsy"--Provided by publisher.

Contents:
Machine generated contents note: Preface; Introduction; Acetazolamide; ACTH; Carbamazepine; Clobazam; Clonazepam; Diazepam; Eslicarbazepine; Ethosuximide; Ezogabine
see retigabine; Felbamate; Fosphenytoin; Gabapentin; Lacosamide; Lamotrigine; Levetiracetam; Lorazepam; Methsuximide; Midazolam; Oxcarbazepine; Paraldehyde; Permapanel; Phenobarbital; Phenytoin; Piracetam; Pregablin; Primidone; Retigabine; Rufinamide; Stiripentol; Sulthiame; Tiagabine; Topiramate; Valproate; Vigabatrin; Zonisamide; Abbreviations; Interaction table; Index.

Contents:
Long-term selection experiments : epistasis and the response to selection / Charles Goodnight
Finding the epistasis needles in the genome-wide haystack / Marylyn D. Ritchie
Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits / Li Ma, Alon Keinan, and Andrew G. Clark
Epistasis for quantitative traits in Drosophila / Trudy F. C. Mackay
Epistasis in the risk of human neuropsychiatric disease / Scott M. Williams
On the partitioning of genetic variance with epistasis / José M. Álvarez-Castro and Arnaud Le Rouzic
Measuring gene interactions / Thomas F. Hansen
Two rules for the detection and quantification of epistasis and other interaction effects / Günter P. Wagner
Direct approach to modeling epistasis / Rong-Cai Yang
Capacitating epistasis
detection and role in the genetic architecture of complex traits / Mats E. Pettersson and Örjan Carlborg
Compositional epistasis : an epidemiologic perspective / Etsuji Suzuki and Tyler J. VanderWeele
Identification of genome-wide SNP-SNP and SNP-clinical boolean interactions in age-related macular degeneration / Carlos Riveros [and eight others]
Epistasis analysis using information theory / Jason H. Moore and Ting Hu
Genome-wide epistasis and pleiotropy characterized by the bipartite human phenotype network / Christian Darabos and Jason H. Moore
Network theory for data-driven epistasis networks / Caleb A. Lareau and Brett A. McKinney
Epistasis analysis using multifactor dimensionality reduction / Jason H. Moore and Peter C. Andrews
Epistasis analysis using ReliefF / Jason H. Moore
Epistasis analysis using artificial intelligence / Jason H. Moore and Doug P. Hill.

Summary: "Despite misguided attempts to discourage them, eponyms continue to enrich the language and literature of medicine"--Provided by publisher.

Summary: Epstein's Inborn Errors of Development provides essays on pathways of development and thoughtful reviews of dysmorphic syndromes for which the causative gene has been identified. It is a top-to-bottom revision of the landmark text that both revolutionized and accelerated the field of human genetics.

Summary: This first-of-its-kind textbook marks a revolutionary effort to reform medical education nationally by providing a comprehensive, high-quality resource to serve as a foundation for lesbian, gay, bisexual, transgender, and queer (LGBTQ) health education across multiple disciplines. Addressing the decades-long unequal weight of medical education generally offered about the care of LGBTQ people, The Equal Curriculum was created to advance clinicians' competencies in optimizing the health of LGBTQ people. This textbook is designed to be integrated into health sciences curricula and offers pointed strategies to evaluate the integration of LGBTQ health topics. Starting with a brief overview, chapters 1 through 4 cover general content that is highly relevant to all health professionals working with LGBTQ people. Chapters 5 through 12 focus on specific patient populations and clinical specialties, and chapters 13 and 14 cover special topics. Key points in each chapter are highlighted to aid in the comprehension, and case vignettes are provided throughout the textbook, allowing learners to apply the content to clinical scenarios in order to evaluate how the application of relevant knowledge may impact health outcomes. Questions similar to National Board of Medical Examiners (NBME) style are provided in most chapters to assist in the application of content. As major addition to the clinical literature, The Equal Curriculum: Student and Educator Guide to LGBTQ Health should be of great interest to health sciences instructors, medical students in their preclinical and clinical phases, and trainees from other disciplines, such as physician assistants, nurses, social workers, and public health professionals.

Contents:
Section I: Foundational Sociological, Health Disparities, Health Research, and Medicolegal Concepts for the LGBT Community
Chapter 1: Language and History of LGBT People
Chapter 2: LGBT Health Disparities
Section II: Interdisciplinary Approach to Care for LGBT People
Chapter 3: The LGBT-Friendly Care Encounter
Chapter 4: Interdisciplinary Approach to Care
Chapter 5: Screening and Prevention
Section III: Clinical Care of the LGBT Community
Chapter 6: Child and Adolescent Medicine
Chapter 7: Adult Primary Care
Chapter 8: Sexual Health
Chapter 9: Transgender Health
Chapter 10: Emergency Medicine
Chapter 11: HIV/AIDS
Chapter 12: Psychiatry and Neurology
Section IV: Emerging Topics in LGBT Health
Chapter 13: Data Collection and Research
Chapter 14: Topics in Global LGBT Health
Appendices.

Contents:
Dark horse colors : bay, chestnut, black, and brown
Modifications affecting most colors
Dilutions of the basic dark colors
Overview of the genetic control of horse color
Patterns with individually distribute white hairs
Nonsymmetrical patches of white : white marks, paints, and pintos
Overview of patterns adding white
Horse color and horse breeding
Peculiarities of hair growth
Donkey color
Summary tables.

Contents:
Infection and immunity
Pharmacology : principles, antimicrobials, and NSAIDs
Recognizing and treating pain in horses
Critical care
Internal medicine and clinical nutrition
Clinical epidemiology and evidence-based medicine
Clinical approach to commonly encountered problems
Disorders of the respiratory system
Disorder of the cardiovascular system
Disorders of the musculoskeletal system
Disorders of the neurologic system
Disorders of the gastrointestinal system
Disorders of the liver
Disorders of the urinary system
Disorders of the hematopoietic system
Disorders of the endocrine system
Disorders of the eye and vision
Disorders of the skin
Disorders of the reproductive tract
Disorders of foals
Toxicologic problems.

Contents:
Part 1: Overview: from basic research to caring for the laminitis patient. Historical perspective on equine laminitis / Donald M. Walsh and Teresa A. Burns
Laminitis: an overview / James K. Belknap
Anatomy and function of the equine digit / A.H. Parks
Lamellar function at the cellular level / Christopher C. Pollitt
Digital biomechanics relevant to laminitis / Jonathan Merritt, Helen Davies and Andrew H. Parks
Part 2: Pathophysiology of laminitis. Overview / James K. Belknap
Experimental models of laminitis: starch overload / Susan C. Eades
Experimental models of laminitis: oligofructose overload / Christopher C. Pollitt and Gabriel J. Milinovich
Experimental models of laminitis: black walnut extract / John F. Peroni
Experimental models of laminitis: hyperinsulinemia / Catherine McGowan and Janet Patterson-Kane
Hemodynamic events in laminitis / John F. Peroni, Susan C. Eades and Simon R. Bailey
The role of thrombosis and coagulation in equine laminitis / Simon R. Bailey
Leukocytes and inflammatory signaling in laminitis: leukocytes / Rafael R. Faleiros and James K. Belknap
Leukocytes and inflammatory signaling in laminitis: inflammatory signaling / Britta Leise
Role of proteases in laminitis / Samuel J. Black, Le Wang, Erica Pawlak, Fengqiu Zhang, John Loftus and Dominique Alfandari
Endocrine and metabolic dysregulation in laminitis: role of pituitary dysfunction / Philip J. Johnson
Endocrine and metabolic dysregulation in laminitis: role of corticosteroids / Philip J. Johnson
Metabolic syndrome in humans and horses: the relationship between obesity and insulin resistance / Teresa A. Burns and Ramiro E. Toribio
Dysregulation of the lamellar basal epithelial cell in laminitis: role of the cytoskeleton and cell junctions / Christopher C. Pollitt
Structural dynamics of displacement of the distal phalanx / Andrew H. Parks
Part 3: Clinical presentation of equine laminitis. General clinical aspects of the laminitis case / Andrew van Eps
Sepsis-related laminitis / Susan C. Eades
Laminitis in equine metabolic syndrome / Andy E. Durham
Laminitis in pituitary pars intermedia dysfunction / Philip J. Johnson
Supporting limb laminitis / Gary M. Baxter
Part 4: Diagnostic evaluation of equine laminitis. Detailed physical examination for laminitis / Richard A. Mansmann and Hans H. Castelijns
Diagnostic imaging / Andrew H. Parks and James K. Belknap
The digital venogram / Amy Rucker
Endocrine and metabolic evaluation in horses with laminitis / Ramiro E. Toribio and Teresa A. Burns
Part 5: Medical treatment of the laminitic patient. General supportive care for the laminitis case / Andrea E. Floyd and Debra R. Taylor
Common therapies: anti-inflammatory therapy / Thomas J. Divers
Vasoactive drug therapy / Simon R. Bailey and Susan C. Eades
Analgesia / Bernd Driessen and Laura Zarucco
Digital hypothermia / Andrew W. van Eps and Christopher C. Pollitt
Equine sepsis / Samuel D. Hurcombe and Susan J. Holcombe
Equine metabolic syndrome / Andy E. Durham
Pituitary pars intermedia dysfunction / Dianne McFarlane, Philip J. Johnson and Harold C. Schott
Part 6: Treatment of laminitis: digital support and stabilization of the distal phalanx. Therapeutic shoes: application of principles / Stephen E. O'Grady
Solear support techniques / Raul J. Bras
Approaching digital management prior to displacement of the distal phalanx / Randy B. Eggleston
Hoof care management of horses with displacement of the distal phalanx / Andrew H. Parks
Part 7: Treatment of the laminitis case. The use of casts in equine laminitis / James K. Belknap and Raul J. Bras
Deep digital flexor tenotomy / R. Wayne Waguespack, Jr
Dorsal hoof wall techniques / Amy Rucker
Complications of laminitis / Robert J. Hunt and James K. Belknap
Part 8: Management of chronic laminitis. Management changes in the laminitis case / Andrew Van Eps, Robert J. Hunt, James K. Belknap and Jeff Ridley
Part 9: Prevention of laminitis. Overview of laminitis prevention / James K. Belknap and Andy E. Durham
Prevention of supporting limb laminitis / Harry J. Markwell and Gary M. Baxter
Prevention of sepsis-related laminitis / Samuel D. Hurcombe and Susan J. Holcombe
Nutritional management for avoidance of pasture-associated laminitis.

Contents:
Section I: Surgical Biology
Section II: Surgical Methods
Section III: Recent Advances in Anesthesia
Section IV: Integumentary System
Section V: Alimentary System
Section VI: Respiratory System
Section VII: Nervous System
Section VIII: Eye and Adnexa
Section IX: Reproductive System
Section X: Urinary System
Section XI: Diagnostic Imaging
Section XII: Musculoskeletal System.

Contents:
1. Access to high cost medicines: an overview
2. Health technology assessment
3. High-cost medicines in England
4. Managed entry agreements and high cost medicine (European perspective)
5. Setting a public health agenda to support access to high-cost medicines
6. Human rights and intellectural property for universal access to new essential medicines
7. Access to high price medicines in Portugal
8. Improving access to high-cost medicines in low income countries in Africa: creating a functioning pharmaceutical system in Uganda
9. Equitable access to biosimilars: an overview
10. Access to high-cost medicines in Europe
11. Access to high-cost medicines in Australia
12. Access to high-cost medicines in New Zealand
13. Access to high-cost medicines in Wales
Index.

Contents:
Introduction
Exploitation
Common heritage of humankind
The altruism argument
The "no value added" argument
Justice and exploitation in bilateral exchanges
Undue inducement and coercion
Risks to indigenous peoples as vulnerable populations
Closing chapter.

Summary: This compendium of clinical practice guidelines and policy statements from the AAP helps equip clinicians to provide equitable and inclusive care to vulnerable and underserved pediatric populations.

Summary: "All humans have bias, and as a result, so do the institutions we build. Internationally sought after diversity consultant Tiffany Jana offers concrete ways for anyone to work against institutional bias no matter what their position is in an organization. While it is easy to identify intentionally built systems of oppression like Jim Crow or the paralysis caused by the glass ceiling for women in the workplace, confronting systems that perpetuate subtle, unconscious bias is much harder. Erasing Institutional Bias will help people tackle structural bias regardless of their positional power. Eliminating systemic bias can seem an insurmountable task from the vantage point of an ordinary individual, yet Jana and Mejias empower readers to recognize that each of us has the ability to affect systemic bias through a deliberate, coordinated effort. Institutional bias afflicts all industries --including business, education, health care, government, tech, the arts, nonprofits, and finance and banking. Among the types of institutional bias addressed are hiring bias, gender bias, racial bias, occupational bias, and customer bias. Jana and Mejias focus their attention on bias in the workplace and give readers practices and activities to create organizational trust to challenge these implicit biases. Erasing Institutional Bias will help people recognize that each of us has the power to affect systemic bias. Each of us can evaluate our own current role in perpetuating systemic bias and define our new role in breaking down systemic bias"-- Provided by publisher.

Contents:
Ch. 1. Understanding the problem
ch. 2. Start with you
ch. 3. Occupational bias
ch. 4. Gender bias
ch. 5. Racial bias
ch. 6. Hiring/advancement bias
ch. 7. Customer bias
ch. 8. Retribution bias
ch. 9. Erasing retribution bias.

Summary: "Recent years have brought major shifts in the way endoscopic retrograde cholangiopancreatography is used in everyday practice, including the incorporation of endoscopic ultrasound (EUS) techniques with ERCP. The 4th Edition of this practical reference helps you make the most of today's ERCP in your practice, with authoritative, highly illustrated guidance on every aspect of this complex tool, including coverage of the latest techniques both in print and on video"-- publisher's description.

Contents:
General topics
Techniques
Approach to clinical problems.

Summary: "Authored by the very best, this is the perfect "how-to" guide to mastering a crucial yet complex gastrointestinal procedure. Peter Cotton and Joseph Leung have once again assembled many of the world's leading experts in this field to provide clear and concise guidance. There are chapters on "How to do" all of the specific manoeuvers, followed by chapters on "When to do" them (and when not to). Key highlights include the following: Full coverage of the entire range of both standard and advanced techniques, using a highly practical approach, Strong focus on patient education, safety, and minimizing risks, Twenty-four outstanding procedural videos of the experts performing ERCP, ideal for improving best practice techniques, Over 250 excellent illustrative photos, X rays, and anatomical drawings, "Tips and tricks" and key points throughout to aid rapid understanding, Reference to the latest ASGE, ACG, ASG, and UEGW guidelines throughout The book covers topics including simulation training, formal credentialing and certification, wire-guided cannulation techniques, pancreatic stenting, short wire technology, cholangioscopy, plastic versus metal stents, radiofrequency ablation, sphincter manometry, and ERCP in acute pancreatitis. Brought to you by world pioneers in endoscopy, ERCP: The Fundamentals, 2nd Edition, is an essential purchase for gastroenterologists and endoscopists of all levels"-- Provided by publisher

Contents:
List of Contributors ix Introduction: Developments in ERCP over 50 Years xiii
Section 1 Preparation 1 1 Training and Assessment of Competence (Preparing the Endoscopist) 3; Joseph W. Leung and Peter B. Cotton 2 Preparing the Facilities and Equipment 17; Joseph W. Leung and Andrew Yen 3 ERCP: The Team 29; Phyllis Malpas 4 Minimizing Duodenoscope Infections 39; Catherine Bauer 5 Patient Education and Consent 45; Peter B. Cotton 6 Risk Assessment and Reduction 49; Erin Forster and Joseph Romagnuolo 7 Sedation, Anesthesia, and Medications 67; John J. Vargo, II
Section 2 Techniques 75 8 Standard Devices and Techniques 77; Joseph W. Leung 9 When Standard Cannulation Approaches Fail 131; Sundeep Lakhtakia and Shyam Varadarajulu 10 Intraductal Therapies 149; Zaheer Nabi and D. Nageshwar Reddy 11 Endoscopic Ampullectomy 165; Michael Bourke 12 The Radiology of ERCP 181; Stuart Ashley Roberts and Derrick Martin 13 ERCP Reporting and Documentation 199; Lars Aabakken
Section 3 Clinical Applications 209 14 ERCP in Acute Cholangitis 211; Wei-Chih Liao and Hsiu-Po Wang 15 ERCP Peri-Cholecystectomy 223; Paul R. Tarnasky 16 Difficult Bile Duct Stones 243; Majid A. Almadi and Alan Barkun 17 Patients with Obscure Biliary Pain; Sphincter of Oddi Dysfunction 257; Peter B. Cotton 18 Benign Biliary Strictures 263; John T. Cunningham 19 The Role of ERCP in Pancreaticobiliary Malignancies 275; John G. Lee 20 ERCP in Acute and Recurrent Acute Pancreatitis 291; Robert A. Moran and Gregory A. Coté 21 Chronic Pancreatitis 305; Benjamin L. Bick, Evan L. Fogel, and Stuart Sherman 22 Role of ERCP in Complicated Pancreatitis 321; Todd H. Baron 23 ERCP in Children 333; Moises Guelrud and Andres Gelrud
Section 4 Quality and Safety 357 24 Adverse Events: Definitions, Avoidance, and Management 359; Peter B. Cotton and B. Joseph Elmunzer 25 Ensuring Really Competent Practice 385; Peter B. Cotton Index 393

Summary: This volume provides a comprehensive review of ERCP and EUS and the clinical conditions for which they are employed. Presented in a case-based format with accompanying videos, it will serve as a valuable practical clinical resource for gastroenterologists with an interest in ERCP and EUS. The text highlights major techniques involved in ERCP, reviews complications and recent data on preventing post-ERCP pancreatitis, and discusses important issues in ERCP training. The EUS chapters review the breadth of equipment available for performing EUS and EUS-FNA, detail the technique of performing EUS-FNA, and explore pertinent issues with training and assessing competency analogous to ERCP training. Valuable insights on the basics of cytopathology relevant to the endosonographer are summarized. The classic indication for EUS of staging luminal cancers is also examined in detail, while pancreaticobiliary indications are discussed highlighting newer adjunctive technologies including elastography and contrast-enhanced EUS. ERCP and EUS: A Case-Based Approach will serve as a very useful resource for physicians who perform or refer patients for ERCP and EUS. It provides a concise yet comprehensive summary of the current status of ERCP and EUS that will help guide patient management and stimulate clinical research. Supplementary video files are available for this book and can be accessed at http://link.springer.com/book/10.1007/978-1-4939-2319-9.

Contents:
Training in Endoscopic Retrograde Cholangiopancreatography
Indications for ERCP
Overview of ERCP Complications: Prevention and Management
ERCP from Soup to Nuts: Evaluation, Preparation, Execution and Follow-up
Biliary Infections
Diagnosing Biliary Strictures and Indeterminate Biliary Strictures
Management of Biliary Structure and Bile Duct Injury
Other Benign Biliary Strictures (Sclerosing cholangitis, autoimmune cholangitis, post-liver transplant)
Choledochal Cysts: Evaluation and Management
Acute Biliary Pancreatitis: Image, Intervene or Observe?
Endoscopic Management of the Complications of Acute Pancreatitis
ERCP in Chronic Pancreatitis
Idiopathic Acute Pancreatitis and Sphincter of Oddi Dysfunction: The Diagnostic and Therapeutic Role of ERCP and Sphincter of Oddi Manometry
ERCP in Other Pancreatic Disorders
Bleeding From the Papilla
ERCP in Post-Surgical Patients
Ampullectomy
ERCP in Pregnancy
Pediatric ERCP
Training in Endoscopic Ultrasound
Equipment and Approach
Techniques of Endoscopic Ultrasound-Guided Fine Needle Aspiration
Essential Cytopathology Concepts for the Endosonographer
Esophageal Cancer
EUS in Gastric Cancer and Thickened Gastric Wall
Rectal Cancer and Anal Sphincter Disorders
Subepithelial Lesions
Endosonography of the Mediastinum
EUS in Pancreatic Tumors
EUS in Pancreatic Cysts
EUS and EUS-FNA in Acute Pancreatitis, Chronic Pancreatitis and Autoimmune Pancreatitis
Endoscopic Ultrasound-Guided Fine Needle Injection
EUS-guided Bilio-pancreatic Drainage.

Summary: This concise guide to the often overlooked association between erectile dysfunction and hypertension/cardiovascular disease covers a wide range of aspects of importance to the clinician. It examines the impact of antihypertensive drug therapy on erectile function and explains how the management of erectile dysfunction in hypertensive patients depends on a variety of factors. Different treatment approaches are described, including lifestyle modification, PDE-5 inhibitors and other novel agents, and behavioral therapy, and helpful therapeutic algorithms are presented. A further focus of the book is the potential role of erectile dysfunction as an early diagnostic indicator of asymptomatic coronary artery disease and a prognostic marker for cardiovascular events. In addition, key background information is supplied on epidemiology and pathophysiology, and the significance of erectile dysfunction in different patient groups, such as the elderly and those with chronic kidney disease, is examined. Erectile dysfunction is a major public health problem affecting more than ten percent of the general male population and is now considered to be predominantly of vascular origin. This book will be informative and of practical value for all practitioners responsible for caring for the very many patients who experience erectile dysfunction in the setting of hypertension and cardiovascular disease.

Summary: "Originating from the Ernest E. Moore Shock Trauma Center at Denver Health, this new volume in the Illustrated Tips and Tricks series, Ernest E. Moore Shock Trauma Center at Denver Health Illustrated Tips and Tricks in Trauma Surgery, provides succinct, precise information from Dr. Ernest E. Moore, Charles J. Fox, Fredric M. Pieracci, and a wide range of experts on tackling technical problems in trauma surgery. Practical, hands-on content conveys knowledge gained from years of surgical experience, including nuggets of wisdom unique to this particular institution. Illustrations and operative photos are used liberally throughout the book to demonstrate surgical techniques and provide a handy visual complement to the text."-- Provided by publisher.

Contents:
Erosive tooth wear : a multifactorial condition of growing concern and increasing knowledge / A. Lussi, T.S. Carvalho
Is erosive tooth wear an oral disease? / C. Ganss
Diagnosis of erosive tooth wear / C. Ganss, A. Lussi
The interaction between attrition, abrasion, and erosion in tooth wear / R.P. Shellis, M. Addy
Challenges in assessing erosive tooth wear / V. Margaritis, J. Nunn
Prevalence, incidence, and distribution of erosion / T. Jaeggi, A. Lussi
Prevalence of erosive tooth wear in risk groups / N. Schlueter, A. Bjorg Tveit
The histological features and physical properties of eroded dental hard tissues / C. Canss, A. Lussi, N. Schlueter
Dentine hypersensitivity / N. West, J. Seong, M. Davies
Methods for assessment of dental erosion / T. Attin, F.J. Wegehaupt
Erosion in relation to nutrition and the environment / M.E. Barbour, A. Lussi
Oral hygiene products, medications, and drugs
hidden aetiological factors for dental erosion / E. Hellwig, A. Lussi
Understanding the chemistry of dental erosion / R.P. Shellis, J.D.B. Featherstone, A. Lussi
Intrinsic causes of erosion / R. Moazzez, D. Bartlett
The potential of saliva in protecting against dental erosion / H.T. Hara, D.T. Zero
The pellicle and erosion / M. Hannig, C. Hannig
The role of oral hygiene : does toothbrushing harm? / A. Wiegand, N. Schlueter
Risk assessment and causal preventive measures / A. Lussi, A. Hellwig
The role of fluoride in erosion therapy / M.C. Huysmans, A. Young, C Ganss
Alternatives to fluoride in the prevention and treatment of dental erosion / M.A.R. Buzalaf, A.C. Magalhaes, A. Wiegand
Restorative therapy of erosive lesions / A. Peutzfeldt, T. Jaeggi, A. Lussi
Erosive tooth wear in children / T.S. Carvalho, A. Lussi, T. Jaeggi, D.L. Gambon.

Contents:
1. Introduction / Raouf E. Nakhleh
2. The landscape of error in surgical pathology / Frederick A. Meier
3. General principles of how errors occur and how they may be reduced / Maxwell L. Smith, Stephen S. Raab
Part 1. Pre-analytic factors contributing to errors and error prevention. 4. Error reduction in the pre-analytical process / Richard W. Brown
5. Application of lean principles to pre-analytic and analytic processes / Anil Vasdev Parwani, Seung Lyung Park, Liron Pantanowitz
Part 2. Analytic factors contributing to errors and error prevention
6. Clinical history and clinical correlation / Keith E. Volmar
7. Knowledge, training, and experience / Amelia Huck, Vania Nosé
8. Standardization of diagnostic terminology and criteria: a prelude for error reduction / Raouf E. Nakhleh
9. Ancillary studies: contribution to error and error prevention / Paul E. Swanson
10. Optimization of case reviews in different practice settings / Raouf E. Nakhleh
Part 3. Post-analytic factors leading to errors and error prevention. 11. The complete surgical pathology report / Michael O. Idowu
12. Communicating effectively in surgical pathology / Carolyn Mies
13. Error prevention in transcription and report distribution / Shannon J. McCall
14. Error management: legal and regulatory responsibilities / Timothy Craig Allen.

Summary: The 1st edition of Error Reduction and Prevention in Surgical Pathology was an opportunity to pull together into one place all the ideas related to errors in surgical pathology and to organize a discipline in error reduction. This 2nd edition is an opportunity to refine this information, to reorganize the book to improve its usability and practicality, and to include topics that were not previously addressed. This book serves as a guide to pathologists to successfully avoid errors and deliver the best diagnosis possible with all relevant information needed to manage patients. The introductory section includes general principles and ideas that are necessary to understand the context of error reduction. In addition to general principles of error reduction and legal and regulatory responsibilities, a chapter on regulatory affairs and payment systems which increasingly may be impacted by error reduction and improvement activities was added. This later chapter is particularly important in view of the implementation of various value-based payment programs, such as the Medicare Merit-Based Incentive Payment System that became law in 2015. The remainder of the book is organized in a similar manor to the 1st edition with chapters devoted to all aspects of the test cycle, including pre-analytic, analytic and post-analytic. The 2nd Edition of Error Reduction and Prevention in Surgical Pathology serves as an essential guide to a successfully managed laboratory and contains all relevant information needed to manage specimens and deliver the best diagnosis.

Contents:
General Principles of How Errors Occur and How they May Be Reduced
Error Management: Legal and Regulatory Responsibilities
Quality Performance and Compensation Considerations
Error Reduction in the Preanalytical Process
Ancillary Studies: Contribution to Error and Error Prevention
Work Habits Contributing to Error in Surgical Pathology
Clinical history and clinical correlation
Standardization of Diagnostic Terminology and Criteria: A Prelude for Error Reduction
Optimization of Case Reviews in Different Practice Settings
Pathologists' Knowledge, Experience and Judgement in Diagnostic Error Prevention (Pathologists' Competence)
The Complete Surgical Pathology Report
Communicating Effectively in Surgical Pathology
Error Prevention in Transcription and Report Distribution
Leveraging Information Technology in Error Prevention
Tracking Report Defects
Root Cause Analysis in Surgical Pathology
Disclosure of Pathology Error to Treating Clinicians and Patients.

Summary: This book describes and illustrates the gamut of errors that may arise during the performance and interpretation of imaging of both nontraumatic and traumatic emergencies, using a head-to-toe approach. The coverage encompasses mistakes related to suboptimal imaging protocols, failure to review a portion of the examination, satisfaction of search error, and misinterpretation of imaging findings. The book opens with an overview of an evidence-based approach to errors in imaging interpretation in patients in the emergency setting. Subsequent chapters describe errors in radiographic, US, multidetector CT, dual-energy CT, and MR imaging of common as well as less common acute conditions, including disorders in the pediatric population, and the unique mistakes in the imaging evaluation of pregnant patients. The book is written by a group of leading North American and European Emergency and Trauma Radiology experts. It will be of value to emergency and general radiologists, to emergency department physicians and related personnel, to general and trauma surgeons, and to trainees in all of these specialties.

Summary: This book offers a thorough, clear and practical guide to identifying, preventing and correcting any error or bias that may arise during the interpretation and reporting of medical images. It combines information and insights from the fields of radiology, expertise theory, cognitive psychology, and advanced learning practices with the author's considerable clinical (radiologic) experience. In addition, the book features an extensive "Teaching Cases Section" that simulates real-world situations, giving readers an opportunity to practice what they have just learned. The purpose of the book is to provide readers with essential information and strategies, and to point out the deficiencies of the current radiology education system, in order to minimize the occurrence and the clinical impact of errors in imaging by offering the proper education and training for imaging professionals. It offers a valuable guide for diagnostic radiologists and all other imaging professionals, whether in training or in practice. Though the main emphasis is on computed tomography and magnetic resonance, the general principles are applicable to all conventional imaging modalities. .

Contents:
Perception and cognition in medical imaging
Definition of errors in imaging
Categories or errors in imaging
The radiology report
Mechanisms of errors
Expertise and competence
Error reducing strategies
Conclusions and personal thoughts about our education
Teaching cases
References
Index. .

Contents:
Errors : terminology and background
Errors : organizations, individuals and unsafe acts
Reporting and analyzing patient safety incidents
Equipment and technical error in veterinary anesthesia cases
Medication errors in veterinary anesthesia
Errors of clinical reasoning and decision making in veterinary anesthesia
Errors of communication and teamwork in veterinary anesthesia
Error prevention in veterinary anesthesia
Epilogue.

Contents:
Part 1. What is prevention and why do we need it?
Part 2. Practical aspects of prevention
Part 3. Setting up preventive cardiology initiatives.

Summary: Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.

Contents:
Shigella and enteroinvasive Escherichia coli / Ilia Belotserkovsky and Philippe J. Sansonetti
Enteroaggregative Escherichia coli / Claire Jenkins
TheType III secretion system of pathogenic Escherichia coli / Sabrina L. Slater, Agnes m. Sagfors, Dominic J. Pollard, David Ruano-Gallego and Gad Frankel
Modulation of host cell processes by T3SS effectors / Avinash R. Shenoy, R. Christopher D. Funiss, Philippa J. Goddard and Abigail Clements
The 2011 German Enterohemorrhagic Escherichia coli O104:H4 outbreak - the danger is still out there / Stefanie Kampmeier, Michael Berger, Alexander Mellmann, Helge Karch, and Petya Berger
Extraintestinal pathogenic Escherichia coli / Dvora Biran and Eliora Z. Ron
Pandemic bacteremic Escherichia Coli strains: evoluation and emergence of drug-resistant pathogens / Yael Yair and Uri Gophna
Current trends in antimicrobial resistance of Escherichia coli / Yossi Paitan
Vaccines against Escherichia coli / Barbara Nesta and Mariagrazia Pizza.

Summary: Esophageal Gastric and Disorders in Infancy and Childhood includes a wide spectrum of different diseases. These range from congenital malformations such as esophageal atresia (EA), necessitating an experienced team of pediatric surgeons and neonatologists immediately after birth, up to gastro-esophageal reflux disease in elder children, necessitating the pediatric gastroenterologist and visceral surgeon. In the last few years some fascinating pediatric surgical techniques have evolved, such as the thoracoscopic correction of EA or the FOKER technique for elongation in cases of long-gap EA. Prof. Foker has developed this special traction technique and is one of the world's leading experts in long-gap EA. Moreover Prof. Thomson's has established the gold standard of minimally invasive endoscopic treatments for reflux in childhood. This book aims to bring all specialities and experts in pediatric gastroenterology and surgery together.

Contents:
Esophageal Development
Normal Esophageal Form and Function
Congenital Esophageal Anomalies
Early after EA Repair
Further out from EA Repair
Acquired Esophageal Problems
Gastroesophageal Reflux Disease
The Stomach
Gastric Functional Problems
Index.

Summary: This book provides comprehensive and practical guidance for the management of esophageal cancer. It presents a detailed review of the pathophysiology, clinical staging, treatment, and outcomes of patients with esophageal cancer. Chapters cover the epidemiology of the disease, latest diagnostic and staging tools, systemic therapies, and the current open and minimally invasive surgical techniques including transhiatal, Ivor Lewis and McKeown esophagectomy. Esophageal Cancer: Diagnosis and Treatment compiles experience gained across a variety of medical disciplines, with contributions from world renowned surgeons, gastroenterologists, and medical oncologists. Thanks to its multidisciplinary authorship, this book represents a unique resource for anybody who takes care of patients with esophageal cancer.

Contents:
Intro; Preface; Acknowledgments; Contents;
1: Epidemiology and Risk Factors for Esophageal Cancer; Introduction; Epidemiology; Incidence; Esophageal Adenocarcinoma; Esophageal Squamous Cell Carcinoma; Mortality; Survival; Risk Factors; Esophageal Adenocarcinoma; Age and Gender; Ethnicity; Eating Disorders; Obesity; Bulimia Nervosa; Gastroesophageal Reflux Disease; Barrett's Esophagus; Socioeconomic Status; Occupation; Helicobacter pylori Infection; Diet; Hot Food and Beverage; Meat Consumption; Fruit and Vegetables; Minerals and Vitamins; Flavonoids; Vitamin D; N-Nitrosodimethylamine (NDMA) FolateDrugs; Sex Steroids; Proton Pump Inhibitors; Bisphosphonates; Nonsteroidal Anti-inflammatory Agents and Aspirin; Statins; Alcohol Consumption and Tobacco Smoking; Metabolic Disorders; Esophageal Squamous Cell Carcinoma; Age and Gender; Ethnicity; Alcohol Consumption and Tobacco Smoking; Socioeconomic Status; Occupation; Opium; Diet; Hot Food and Beverages; Eggs; Meat Consumption; Pickles; Tea and Coffee Consumption; Minerals and Vitamins; Toenail Mineral Concentration; NDMA; Folate; Diet-Related Inflammation; Maté Consumption; Tooth Loss and Oral Hygiene; Oral Cancer; Infectious Disease Viral DiseaseHelicobacter pylori Infection; Medications; Bisphosphonates; Conclusions; References;
2: Cellular and Molecular Biology of Esophageal Cancer; Introduction; Histological Differences; Applications of Molecular and Cellular Biology; Establishment of an Infectious Cofactor; Human Papillomavirus; Epstein-Barr Virus; Bacteria; Understanding Genetic Mechanisms; Genetic Profiles; MicroRNAs (miRNAs); Cancer Stem Cells; Prognostic Information; Predication of Progression; Guidelines for Medical Therapies; Prediction of Response to Medical Therapies; Predictors for Targeted Therapy Research Sources for Molecular and Cellular Studies in Esophageal CancersTissue Studies; Cancer Cell Lines; Animal Models; References;
3: Pathology of Premalignant and Malignant Disease of the Esophagus; Introduction; Pathology of Adenocarcinoma and Its Precursor Lesions; Precursor Lesions of Esophageal Adenocarcinoma: Barrett's Esophagus and Barrett's Esophagus-Associated Dysplasia; Esophageal Adenocarcinoma; Pathology of Squamous Cell Carcinoma and Its Precursor Lesions; Precursor Lesions of Esophageal Squamous Cell Carcinoma; Esophageal Squamous Cell Carcinoma; Assessment of Specimens HER2-Neu TestingMicrosatellite Instability Testing; PD-L1 Testing; References;
4: Barrett's Esophagus: Diagnosis and Management; Introduction; Natural History and Risk Factors; Natural History; Risk Factors for BE and EAC; Risk Factors for BE and Strategies to Identify a Screening Population; Risk Factors for the Progression of BE to EAC; Diagnosing Barrett's Esophagus (BE): Current Criteria and Areas of Controversy; Tissue-Based Diagnostic and Risk Markers; BE Surveillance: Current Clinical Strategies and Features That Affect the Implementation of the Surveillance Program

Contents:
1. Esophageal Anatomy and Physiology
2. Esophageal Diseases: Radiologic Images
3. Gastroesophageal Reflux Disease: Pathophysiology
4. Gastroesophageal Reflux Disease: Diagnostic Evaluation
5. Gastroesophageal Reflux Disease: Treatment
6. Treatment of Paraesophageal Hernias
7. Extra-Esophageal Manifestation of Gastroesophageal Reflux Disease
8.Epiphrenic Diverticulum
9. Evaluation and Treatment of Zenker's Diverticulum
10. Achalasia: Pathophysiology and Diagnostic Evaluation
11. Achalasia: Treatment
12.Begnign Esophageal Tumors: Evaluation and Treatment
13. Gastroesophageal Reflux Disease: From Heartburn to Cancer
14. Barrett's Esophagus: Treatment Options
15.Esophageal Cancer: Evaluation
16. Esophageal Cancer: Surgical Treatment
17. Esophageal Cancer: Neo-Adjuvant and Adjuvant Therapy.

Summary: This book provides a comprehensive, state-of-the art, evidence-based review of esophageal preservation and replacement and serves as a valuable resource for clinicians, surgeons and researchers with an interest in this field. The text reviews in detail the embryology, anatomy and physiology of the esophagus relevant to esophageal replacement. The indications, advantages, disadvantages, complications and long-term outcomes of all techniques available are also discussed. The latest advances in this field including the laparoscopic and thoracoscopic techniques are included with detailed descriptions and figures. Recent advances in tissue engineering techniques for manufacturing a neo esophagus are also discussed in detail. All chapters are written by experts in their fields and includes the most up to date evidence-based data available. Esophageal Preservation and Replacement in Children is one of its kind and serves as a very useful resource for surgeons and researchers all over the world. It provides a comprehensive summary of the current status of esophageal preservation and replacement and all the recent advances in this field.

Contents:
Anatomy and Embryology of esophagus
Esophageal physiology and motility in normal and the replaced esophagus
Intrathoracic extracorporeal lengthening
Intrathoracic Intracorporeal laparoscopic elongation-external traction
Intrathoracic Intracorporeal laparoscopic elongation-internal traction
Extrathoracic lengthening (Kimura Technique)
Long gap esophageal atresia
Caustic esophageal injuries, GER Strictures and Postoperative strictures
Routes for esophageal replacemen
Gastric tube
Gastric pull up open approach
Gastric pull combined laparoscopic and thoracoscopic approach
Vascularized jejunal tube
Super charged Jejunal tube (microvascular anastomosis
Colonic substitution
Comparative outcomes of esophageal replacement techniques
Tissue engineering of esophagus
Future of esophageal preservation and replacement.

Summary: Esophageal cancer causes an estimated 386,000 deaths worldwide and is the sixth most common cause of death for men. The background characteristics of esophageal cancer treatment are markedly different between Asian and Western countries, however. In tumor histology, squamous cell carcinoma associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barrett?s metaplasia is markedly prevalent in the West. In Asia, especially in Japan, the key persons who play important roles in the management of esophageal cancer patients are surgeons; in the West those roles are filled by medical and radiation oncologists as well as surgeons. The philosophy of surgeons regarding cancer surgery varies from locoregional to local tumor control, particularly in focusing on lymph node dissection. Physicians? approach to surgical adjuvant therapy differs, therefore, between Asia and the West. Considering these East?West differences in esophageal cancer treatment, the currently available results of Western evidence should not be considered directly applicable to esophageal cancer in Asia. In this book, the authors discuss the knowledge base in Japan in terms of treatment of esophageal squamous cell carcinoma. Since this volume contains a wide spectrum of current information and addresses topics surrounding the treatment of patients with esophageal squamous cell carcinoma, it is highly relevant to Asian physicians and researchers as well as to their counterparts in the West.

Contents:
1. Epidemiology of ESCC
2. Pathology of Esophageal Squamous Cell Carcinoma
3. Imaging Diagnosis
4. Endoscopic Diagnosis of Squamous Cell Carcinoma of the Esophagus
5. Stage Classifications: The UICC/AJCC Classifications and The Japanese Classification
6. Comprehensive Registry in Japan
7. Guidelines for Diagnosis and Treatment in Japan
8. Surgery: Transthoracic Esophagectomy
9. Surgery: Minimally Invasive Esophagectomy
10. Surgery: Esophageal reconstruction
11. Neoadjuvant and Adjuvant Therapy
12. Chemotherapy and Chemoradiotherapy 13. Radiation Therapy
14. Endoscopic treatment: EMR and ESD
15. The Hong Kong Experience
16. The Indian Experience.

Summary: This is the second edition of the book, covering a wide spectrum of the latest information relevant to diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). In recent years the incidence rate of esophageal cancer has been increasing; however, the background characteristics of the cancer treatment are significantly different between Asian and Western countries. In tumor histology, ESCC associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barretts metaplasia is remarkably prevalent in the West. In Asia, especially in Japan, surgeons play a significant role in the management of esophageal cancer patients, while medical and radiation oncologists as well as surgeons are important in the West. Considering these East-West differences in management of esophageal cancer, evidence originating in Asia should be more widely disseminated globally. The contributing authors, who have great expertise in their areas of specialization, discuss details in terms of treatment of ESCC, including basic science, diagnosis, surgery, other treatment modalities, Japanese guidelines, and also valuable experiences from other Asian countries. Accordingly, this excellent collection of texts benefits not only oncologists, but all medical and biological researchers involved in the latest ESCC research.

Summary: "As part of the growing and well-known series, Master Techniques in Surgery, edited by Dr. Fischer, this book focuses on esophageal surgery. These specialty volumes complement the well-known Mastery of Surgery book, also edited by Dr. Fischer. While there are many standard textbooks in general surgery, thoracic surgery, and some on esophageal surgery, this book is unique in that it focuses on the technical aspects of esophageal surgery. Esophageal surgery is complex, and this textbook, which is entirely devoted to surgery of the esophagus, should serve as a useful complement to some of the existing comprehensive textbooks in esophageal, general and thoracic surgery, as well as serve as link between a classical textbook and an atlas"-- Provided by publisher.

Contents:
Part I. Surgical Treatment of Gastroesophageal Reflux and Paraesophageal Hernia: Laparoscopic Nissen fundoplication
Laparoscopic partial fundoplication
Fundoplication: open transabdominal approach
Transthoracic Nissen fundoplication
Belsey Mark IV partial fundoplication
Laparoscopic collis gastroplasty
Open collis gastroplasty
Reoperative antireflux surgery
Gastric bypass
Endoscopic antireflux repair: Esophy X
Laparoscopic paraesophageal hernia repair
Open paraesophageal hernia: transthoracic approach
Open paraesophageal hernia and Hill repair: open abdominal approach
Part II. Surgical Treatment of Esophageal Motility Disorders: Achalasia and Esophageal Diverticula: Laparoscopic Heller myotomy and fundoplication for achalasia
Transthoracic approach for achalasia
Open esophageal myotomy and resection of epiphrenic diverticula
Minimally invasive approach to resection of thoracic and epiphrenic diverticula
Open cricopharyngeal myotomy and correction of Zenker's diverticulum
Transoral repair of Zenker's diverticula
Part III. Techniques and Approaches for Esophageal Resection: Transhiatal esophagectomy
Ivor Lewis esophagectomy
En Bloc esophagectomy
Left thoracoabdominal exposure for esophagectomy and complex hiatus pathology
Minimally invasive Ivor Lewis esophagectomy
Esophagectomy with substernal pull-up
Merendino jejunal interposition
Long segment reconstruction with jejunum
Colon interposition
Part IV. Resection of Benign Esophageal Tumors: Open resection of esophageal leiomyoma and GIST
Resection of GIST and leiomyoma: thoracoscopic approach
Part V. Endoscopic Ablative Therapies and Resection: Esophageal radiofrequency ablation for the treatment of Barrett's Esophagus with and without dysplasia
Photodynamic therapy, lasers, and cryotherapy for esophageal neoplasia
Endoscopic mucosal resection
Part VI. Miscellaneous Esophageal Procedures: Esophageal stents
Bougie and balloon dilation of esophageal strictures: malignant and benign
Esophageal perforation
Congenital diaphragmatic hernia repair: open and thoracoscopic.

Summary: "My exposure to studies of esophageal function began in the middle of the 20th century and reflects 50 years of clinical experience and testing using new technology. There was growing interest in the development of techniques to study in-vivo function of the human esophagus. Early pioneer work in the laboratory of Charles Code PhD at the Mayo Clinic led the way with studies using nasogastric intubation with small (2-5 mm diameter) catheters in both healthy volunteers and patients with symptoms likely related to esophageal motility abnormalities. These studies were performed in awake non-sedated patients with a limited number of swallows (traditionally 10) of 5 ml volumes of water or saline, using a catheter filled with water or a small air-filled balloon. In the 1950s and 1960s a growing group of enthusiastic investigators joined the ranks of Code's disciples, expanding awareness of manometric findings in patients presenting with dysphagia, regurgitation, heartburn or chest pain so that by the end of the 20th century the terms "esophagology or esophagologist" were often seen. This was stimulated by their use at the regular international meetings for studies of the esophagus organized every 2-4 years by professor Robert Guilli, a Parisian surgeon. At one of these he organized an election such that I was voted by my international colleagues to receive the title "Pope of Esophagology". Although created in jest, I have enjoyed the respect it carries for many years. I believe that an esophagologist is best defined as a basic or clinical scientist with a focus on studies of esophageal function or disease"-- Provided by publisher

Contents:
Front Matter
Esophageal Symptoms. Symptom Overview and Quality of Life / John W Jacobs
Diagnosis and Treatment of Esophageal Chest Pain / Edward C Oldfield, Parth J Parekh, David A Johnson
Disorders Causing Oropharyngeal Dysphagia / Patrick Sanvanson, Reza Shaker
The Esophagus / Magnus Halland, David A Katzka
Esophageal Physiology and Testing. Functional Anatomy and Physiology of Swallowing and Esophageal Motility / Arvind Rengarajan, C Prakash Gyawali
Radiology of the Pharynx and Esophagus / Marc S Levine, Stephen E Rubesin
Special Endoscopic Imaging and Optical Techniques for Evaluating the Esophagus / John A Dumot, John J Vargo, Arvind J Trindade
High-Resolution Manometry and Esophageal Pressure Topography / Dustin A Carlson, Peter J Kahrilas
Esophageal Testing Using Multichannel Intraluminal Impedance / Mohamed Khalaf, Amit Agrawal
Ambulatory Monitoring for Reflux / Frank Zerbib, John E Pandolfino
New Diagnostic Tests for GERD / Robert T Kavitt, Michael F Vaezi
Role of Histology and Cytology in Esophageal Diseases / Xiuli Liu, John R Goldblum
Motility Disorders. Achalasia / Guy E Boeckxstaens, Albert J Bredenoord
Non-Achalasia Esophageal Motility Abnormalities / Steven Clayton
Surgery for Esophageal Motor Disorders / Brett Parker, Lee L Swanstrom
Esophageal Webs and Rings / Mohamed Khalaf, Donald O Castell
Esophageal Diverticula / Tara Barry, Adham R Saad, Vic Velanovich
Esophageal Involvement in Systemic Diseases / John O Clarke
Gastroesophageal Reflux Disease. Clinical Spectrum and Diagnosis of GERD Phenotypes / Rena Yadlapati
Hiatus Hernia and Gastroesophageal Reflux Disease / Wout OA Rohof, Andr©♭ JPM Smout
Pathophysiology of Gastroesophageal Reflux Disease / Ravinder K Mittal, Sabine Roman
Pathophysiology of Gastroesophageal Reflux Disease / Shere Paris, Rhonda F Souza
Duodenogastroesophageal Reflux / Daniel Sifrim, Roberto Penagini
Helicobacter pylori and GERD / Kristle Lee Lynch, Gary W Falk
Medical Management of Gastroesophageal Reflux Disease / Felice Schnoll-Sussman, Philip O Katz
Refractory Heartburn / Fahmi Shibli, Ronnie Fass
Endoscopic Therapies for GERD / Kenneth J Chang
Behavioral Treatment of Oropharyngeal and Esophageal Disorders / Joy E Gaziano
Barrett's Esophagus / Puja Sukhwani Elias, Stuart Jon Spechler
Esophageal Strictures / Sajiv Sethi, Joel Richter
ENT Complaints in GERD / Emily C Ambrose, Kenneth C Fletcher, C Gaelyn Garrett
Pulmonary Complications of Gastroesophageal Reflux Disease / Walter W Chan
Pediatric Gastroesophageal Reflux Disease / Rachel Rosen, Samuel Nurko
Challenges in the Understanding and Application of Antireflux Surgery for GERD / Steven R DeMeester, Tom R DeMeester
New Surgical Treatments for GERD / Reginald Bell
Obesity and Gastroesophageal Reflux Disease / Hashem B El-Serag, Aaron P Thrift
Malignant Disease. Tumors of the Esophagus / Michael S Smith, Charles J Lightdale
Endoscopic Treatment of Esophageal Cancer / Prasad G Iyer, Kenneth K Wang
Surgical Treatment for Esophageal Cancer / Luigi Bonavina, Alberto Luporini
Miscellaneous. Eosinophilic Esophagitis / Ikuo Hirano, Evan S Dellon
Foreign Bodies / Rene D Gomez-Esquivel
Medication-Induced Esophageal Injury / David A Katzka
Esophagitis in the Immunocompromised Host / James P Callaway, C Mel Wilcox
Caustic Injuries of the Esophagus / Dhyanesh Patel
Rupture and Perforation of the Esophagus / Phillip S Ge, Gottumukkala S Raju
Cutaneous Diseases of the Esophagus / Michael J Camilleri
Esophageal Disease in Older Patients / Kenneth R DeVault, Sami R Achem
Index

Summary: This book is devoted to all the aspects of pediatric minimally invasive surgery and is written under the patronage of the European Society of Pediatric Endoscopic Surgery (ESPES) with the participation of leading international experts on Pediatric MIS. Comprising more than 50 chapters, the book begins with an introductory section describing the general and technical aspects of MIS approaches including laparoscopy, thoracoscopy, retroperitoneoscopy and robotic surgery. The main part of the book is divided into five subsections, each of which focuses on a specific system: thorax, abdomen, urology, gynecology and varia. For each subsection, the book examines several pathologies, accurately describing their clinical and diagnostic aspects and providing detailed information on the operative techniques, tips and tricks used in their treatment. Further, the book addresses potential complications in MIS and better ways to manage and prevent them. The volume will be of interest for pediatric surgeons, pediatric urologists or other professionals that need to access accurate descriptions of the MIS approaches adopted for the different surgical pathologies. At the same time, it addresses the needs of novices, including trainees, looking for general information on the management of the various diseases encountered in the pediatric population. -- Provided by publisher.

Contents:
PART I: BASICS
Chapter 1: Equipment and Instruments
Chapter 2: Ergonomics in Minimally Invasive Surgery
Chapter 3: Check list and Preoperative Preparation
Chapter 4: Basis of Laparoscopic Approach
Chapter 5: Basis of Retroperitoneoscopic Approach
Chapter 6: Basis of Thoracoscopic Approach
Chapter 7: Basis of Pediatric Robotics
Chapter 8: Training in Pediatric Minimal Access Surgery
Chapter 9: Medico-legal Aspects in Pediatric Minimally Invasive Surgery
Chapter 10: Multimedia Aspects of Pediatric Minimally Invasive Surgery
Chapter 11: A Short History of the European Society of Pediatric Endoscopic Surgeons (ESPES)
Chapter 12: Anesthesia in Pediatric Minimally Invasive Surgery
PART II: CHEST
Chapter 13: Thoracoscopic Lung Biopsy
Chapter 14: Management of Pleural Empyema
Chapter 15: Thoracoscopic Lobectomy
Chapter 16: Thoracoscopic Management of Pulmonary Sequestration
^Chapter 17: Thoracoscopic Management of the Mediastinal Masses
Chapter 18: Primary Focal Hyperhidrosis: Surgical Management
Chapter 19: Thoracoscopic Treatment of Chylothorax
Chapter 20: Thoracoscopic Congenital Diaphragmatic Hernia (CDH) Repair
Chapter 21: Thoracoscopic Repair of Esophageal Atresia and/or Tracheoesophageal Fistula
PART III: ABDOMEN
Chapter 22: Laparoscopic Management of Congenital Morgagni Hernia (CMH)
Chapter 23: Laparoscopic Treatment of Esophageal Achalasia
Chapter 24: Antireflux Surgery for Gastro-Esophageal Reflux Disease (GERD)
Chapter 25: MIS Gastrostomy
Chapter 26: Laparoscopic Pyloromyotomy
Chapter 27: Laparoscopic Jejunostomy
Chapter 28: Minimally Invasive Management of Duodenal and Jejunal Atresia
Chapter 29: Minimally Invasive Surgery for Malrotation of the Intestine and Midgut Volvulus
Chapter 30: Laparoscopic Approach to Intestinal Duplication
^Chapter 31: Laparoscopy and Laparoscopic-assisted Approach for Adhesive Small Bowel Obstruction
Chapter 32: MIS Management of Intussusception
Chapter 33: Current Operative Management of Meckel Diverticulum
Chapter 34: Bariatric Surgery for Pediatric Patients
Chapter 35: Laparoscopic Liver Surgery
Chapter 36: Laparoscopic Management of Choledochal Cyst
Chapter 37: Laparoscopic Cholecystectomy
Chapter 38: Laparoscopic Pancreatic Surgery
Chapter 39: Laparoscopic Splenectomy
Chapter 40: Laparoscopic Partial Splenectomy
Chapter 41: Minimal Invasive Management of Lymphatic Malformations
Chapter 42: Laparoscopic assisted Endorectal Pull-through in Hirschsprung’s Disease and Familial Adenometous Polyposis
Chapter 43: Laparoscopic Approach to Anorectal Malformations
Chapter 44: Laparoscopic Management of Acute Appendicitis
Chapter 45: Laparoscopic Cecostomy for Constipation and Incontinence
^Chapter 46: Laparoscopic Management of Persistent Complete Rectal Prolapse in Children
Chapter 47: Minimal Access Colorectal Surgery in Pediatric Age
PART IV: UROLOGY
Chapter 48: Laparoscopic and Retroperitoneoscopic Nephrectomy
Chapter 49: Laparoscopic Partial Nephrectomy
Chapter 50: MIS Management of Duplex Kidneys
Chapter 51: Laparoscopic Management of Intrinsic Uretero-Pelvic Junction Obstruction (UPJO)
Chapter 52: Laparoscopic Management of Extrinsic Uretero-Pelvic Junction Obstruction (UPJO) by Crossing Vessels
Chapter 53: Laparoscopic Approach to Urinary Stones
Chapter 54: Vesico-Ureteric Reflux (VUR)
Laparoscopic Lich Gregoir Repair
Chapter 55: Vesico-ureteral Reflux (VUR)
Endoscopic Treatment
Chapter 56: Vesico-ureteral Reflux (VUR)
Pneumovesicoscopic Repair
Chapter 57: Laparoscopic Decortication for Renal Cysts in Children
Chapter 58: MIS Management of Urachal Pathology
Chapter 59: Laparoscopic Resection of Wilms’ Tumours
^Chapter 60: Laparoscopic Mitrofanoff Procedure
Chapter 61: MIS Management of Posterior Urethral Valves (PUV)
Chapter 62: Primary Obstructive Megaureter: Endourological Treatment
Chapter 63: Ureterocele: Minimally Invasive Endoscopic Treatment
Chapter 64: Laparoscopic Adrenalectomy in Children
Chapter 65: Endoscopic Management of Bladder Tumors in Children
PART V: GYNAECOLOGY
Chapter 66: Laparoscopic Management of Ovarian Cysts
Chapter 67: Laparoscopy for Ovarian Tumors
Chapter 68: Laparoscopic Approach to Paratubal and Paraovarian Cysts
Chapter 69: Laparoscopic-assisted Vaginoplasty
Chapter 70: Ovarian Cryopreservation
PART VI: MISCELLANEA
Chapter 71: Laparoscopic Inguinal Hernia Repair
Chapter 72: Laparoscopic Management of Pediatric Varicocele
Chapter 73: MIS Management of Pilonidal Sinus Disease
Chapter 74: Laparoscopic Approach to Non Palpable Testis
Chapter 75: Complications in Pediatric MIS
^Chapter 76: Fetoscopy: The Minimally Invasive Fetal Surgery
Chapter 77: Application of Mimimally Invasive Surgery in Pediatric Oncology.

Contents:
v. [1] 1908-1957
v. 2. 1958-1962.

Summary: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.

Contents:
Ch 1: Electron Spin Resonance- An Introdcution
Ch 2: ESR Applications in Healthcare and Pharmaceutical Science
Ch 3: ESR Applications in Paleontology and Geochronology
Ch 4: ESR Applications in Food Science.

Summary: This collection of nine essays provides an entertaining and thoughtful glimpse into trending topics in our lives. The author, Dr. Akula, tackles questions on life, science, and society from a biologists perspective. The book covers a broad range of topics, including common questions with complex answers intermixed with some religion and humor, making it a great read to give your brain cells a boost. The field of Science is massive - in fact, its the size of the universe, which means picking just a few topics to discuss is no mean feat. This book is a start, but there is more to come as Dr. Akula explores various subjects to discuss and shed new light on. This collection of essays will appeal to scientists, and to lay readers with an interest in the natural sciences. Its goal is to ensure that science isnt accessible to only a few people, but is instead disseminated to many. After all, a Smart World is the key to a Better Tomorrow and a Brighter Future.

Contents:
Chapter 1. Understanding Order in the disorder
Chapter 2. Einsteins theory of relativity borrowed from the spice rack of Hinduism?
Chapter 3. Flu or a bug?
Chapter 4. Why I chose evolution over religion!
Chapter 5. It is mi(y) RNA!
Chapter 6. A morons footnote to controlling human brain
Chapter 7. An insiders view!
Chapter 8. Down the Line
Chapter 9: What is intelligence?

Summary: Despite a decreasing number of burns and improvement in mortality of burn patients in the United States, burn injuries are still frequent. Non-burn specialists such as emergency medicine physicians and primary care physicians will inevitably treat burn patients. In many instances, the first clinicians to see burn patients are non-burn specialists in the urgent care, emergency department, or primary care clinic, yet they typically do not have any formal training or exposure to burns in residency. As a result, many clinicians feel uneasy about managing burns even if the burn is minor. If a burn center is in a reasonable proximity, one can transfer the patient, but prior to transfer, or if no burn center is available, these clinicians may have to perform the initial management. It is important that they understand the basic principles of burn care. In times of burn disasters, non-burn specialists are needed to care for burn patients as burn centers can be quickly overwhelmed. They should be able to manage burn patients including stabilization, resuscitation and wound care. The text includes all current management available today for the care of burn patients. It is organized in a stepwise manner with clear information listed in sequential chapter formats. Chapter one offers the basic epidemiology of burn care while chapters three and four discuss the initial assessment and management. The chapter five discusses inhalation injury while the next three chapters focus on burn wound management including face and hand. The majority of chapters that follow center on a specific type of burn or burn patient. The last few chapters discuss aftercare including scar management and burn rehabilitation. Written by experts in the field, Essential Burn Care for Non-Burn Specialists is a valuable guide for any physician involved in burn treatment such as emergency physicians, primary care physicians, and general and plastic surgeons.

Contents:
Intro
Contents
Chapter 1: Epidemiology
Burden of Disease
Incidence
Injuries Managed at Hospitals and Burn Centers
Mortality
Global and Local Inequities
Risk Factors for Fires and Burn Injuries
Age
Children
Elderly
Gender
Cooking and Cookstoves
Occupation
Climate and Seasonality
Comorbidities
Interpersonal and Collective Violence
Data for Burn Injury Prevention and Control
Conclusion
References
Chapter 2: Pathophysiology and Hypermetabolic Response to Burn
Introduction
What Is Hypermetabolism?
Magnitude and Duration Biomarkers and Mediators
Metabolic Consequences: Glucose, Lipids, Amino Acids
Glucose Metabolism
Lipid Metabolism
Protein Metabolism
Targeting Organ Systems: Cardiac, Renal, Gastrointestinal, and Immune Systems
Cardiac
Renal
Gastrointestinal
Immune System
Adipose Tissue
Central Nervous System
Management of Hypermetabolism: Conservative Measures
Nutrition-Calculating Energy Consumption and Nutrient Supplementation
Environment, Early Excision, and Exercise
Management of Hypermetabolism: Pharmacological Intervention
Propranolol Recombinant Human Growth Hormone
Insulin-Like Growth Factor 1/Insulin-Like Growth Factor Binding Protein-3
Insulin
Metformin
Oxandrolone
Testosterone
Conclusion
References
Chapter 3: Initial Assessment of Burn Patient
Introduction
First Aid and Prehospital Considerations
Initial Assessment
Primary Survey
Burn-Specific Secondary Survey
Obtaining a Burn-Specific History
Burn Patient Assessment
Neurologic
Ophthalmologic
Otolaryngologic
Chest and Abdomen
Genitourinary
Extremity
Evaluation of the Burn Wound Triage, Referral, and Transfer Determination
Tertiary Survey
Prehospital and Initial Assessment Considerations for Special Situations
Chemical Injury
Cold Injury
Electrical Injury
Non-accidental Injury
References
Chapter 4: Initial Management and Resuscitation
Introduction
Big Problem or Little Problem?
Airway: Who Needs to be Intubated, and How?
Fluid Resuscitation: Why and How?
Monitoring
Complicated Resuscitation
Management of the Burned Extremity
Wound Care and Pain Management
Supportive Care
Role of the Rehabilitation Team
Teamwork Final Thoughts
References
Chapter 5: Inhalation Injury
Introduction
Pathophysiology
Assessment and Grading
Management
Airway Management
Carbon Monoxide and Hydrogen Cyanide
Mechanical Ventilation
Medical Therapy
Complications
Conclusion
References
Chapter 6: Burn Wound Management
Introduction
Skin Anatomy
Care Algorithm
Minor Burns Treatment
Hospital Admission for Minor Burns
Major Burns Treatment
Escharotomy and Wound Care
Burn Surgery
Burn Excision
Skin Grafting
Autograft Skin
Skin Substitutes
Allograft Skin

Summary: The Essential Burn Unit Handbook is a pocket-sized reference dedicated to the evaluation, diagnosis, care, and treatment of burn patients. It covers the spectrum of burn care, from initial assessment and treatment to long-term sequelae. This second edition includes an added chapter on the criteria for admissions to a burn unit as well as outpatient and follow-up care. It covers a wealth of topics that surgical residents, emergency medicine residents, and critical care fellows often encounter such as patient nutrition, the use of antibiotics, wound care, and some of the unique pathologic conditions seen in this distinct and often critically injured population. The book covers electrical burns, inhalation injury, chemical burns, and pediatric patient management. It also presents a full range of day-to-day management modalities along with sample orders and templates for patient presentation and the organization of notes. A quick-reference glossary includes many of the acronyms and abbreviations used in this setting as well as a list of useful equations and ranges. This book will help you provide better patient care while shortening your learning curve. It stands alone as the most convenient, practical, and informative guide available today for those working with burn patients.

Contents:
Introduction to the burn unit
Pathophysiology
Evaluation, resuscitation, and treatment
Admissions and follow-up care
Wound care, use of antibiotics, and Control of burn wound sepsis
Nutrition
Inhalation injury
General (nonburn) inpatient wound care
Toxic epidermal necrolysis syndrome and Stevens-Johnson syndrome
Electrical burns
Chemical burns
Pediatric burn management.

Contents:
What is autism : history, causes, and current research
Screening and diagnostic assessment
Approaches to providing medical care
Frequent medical conditions and problems
Working with attorneys and other referral sources
Securing services
Infants and preschool children
School-aged children
Adolescents and adults
Behavioral and psychiatric problems : issues and interventions
Considering medications for behavioral and mental health problems
Considering complementary and alternative treatments
Supporting families.

Summary: This book is a concise learning guide dedicated to the full scope of pediatric history-taking and clinical examination for use in OSCEs as well as clinical life.

Contents:
History-taking skills and symptomatology
Basics of history taking
History taking of common pediatric cases
Examination of the newborn and older child
Examination of the newborn
Examination of the older child.

Summary: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine.

Contents:
PART I Essential Pathology
Mechanisms of Disease
1. Molecular Mechanisms of Cell Death 2. Acute and Chronic Inflammation 3. Infection and Host Response 4. Neoplasia
PART II Concepts in Molecular Biology and Genetics
5. Basic Concepts in Human Molecular Genetics 6. The Human Genome: Implications for the Understanding of Human Disease 7. The Human Transcriptome: Implications for the Understanding of Human Disease 8. The Human Epigenome: Implications for the Understanding of Human Disease 9. Clinical Proteomics and Molecular Pathology 10. Integrative Systems Biology: Implications for the Understanding of Human Disease 11. Pathology: The Clinical Description of Human Disease 12. Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease 13. Integration of Molecular and Cellular Pathogenesis
PART IV Molecular Pathology of Human Disease
14. Molecular Basis of Cardiovascular Disease 15. Molecular Basis of Hemostatic and Thrombotic Diseases 16. Molecular Basis of Lymphoid and Myeloid Diseases 17. Molecular Basis of Diseases of Immunity 18. Molecular Basis of Pulmonary Disease 19. Molecular Basis of Diseases of the Gastrointestinal Tract 20. Molecular Basis of Liver Disease 21. Molecular Basis of Diseases of the Exocrine Pancreas 22. Molecular Basis of Diseases of the Endocrine System 23. Molecular Basis of Gynecologic Diseases 24. Molecular Pathogenesis of Kidney Diseases 25. Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations 26. Molecular Biology of Breast Cancer 27. Molecular Basis of Skin Disease 28. Molecular Pathology: Neuropathology
PART V Practice of Molecular Medicine
29. Molecular Diagnosis of Human Disease 30. Molecular Assessment of Human Disease in the Clinical Laboratory 31. Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

Summary: This textbook describes the biology of different stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal cord blood, neural and muscle stem cells and also covers induced pluripotent stem cells and their applications. Further, it includes chapters on organoids, stem-cell based disease modelling, extracellular vesicles and one chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on lectures of the international master program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and participation of collaborating professors from Tongji University Shanghai, the book is a valuable source for students, postdocs and researchers, who would like to have introductory chapters on stem cell biology. It also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Contents:
Hematopoietic Stem Cells
Mesenchymal Stem Cells
Cord Blood Stem Cells
Neural Stem Cells and Their Niche
Skeletal Muscle Stem Cells
Heart Muscle Tissue Engineering
Induced Pluripotent Stem Cells
Epigenetics of Somatic Cell Reprogramming
Human Pluripotent Stem Cells and Neural Regeneration
Dopaminergic Neuron-Related Stem Cells
Liver Disease Modelling
Organoids in Developmental Biology Research and Application
Extracellular Vesicles
Ethics in Stem Cell Applications.

Summary: "This book presents the basic concepts and facts relating to the developmental biology of animals. It is designed as a core text for undergraduate courses from the first to the fourth year, and also for first year graduate students. It is suitable for both biologically based and medically oriented courses. A basic knowledge of cell and molecular biology is assumed, but no prior knowledge of development, animal structure, or histology should be necessary For this, the fourth edition, the work has two authors. Leslie Dale runs the developmental biology teaching at University College London and has brought his invaluable teaching experience as well as his daily contact with cutting edge research to complement the expertise of the senior author, Jonathan Slack. Two technical advances in particular have been incorporated into the text. The first is single cell transcriptome sequencing which provides a completely new way to observe developmental fate and commitment at a molecular level. The second is CRISPR/Cas9, and other methods for targeted genetic manipulation, that have hugely extended the range of what can be done. The book is arranged in four sections and the order of topics is intended to represent a logical progression. The first section introduces the basic concepts and techniques. Chapter 2 "How Development Works" is intended as a very brief summary of developmental mechanisms suitable for introductory lectures. We have moved the biochemistry of signaling systems, formerly in the appendix, into Chapter 4. So now the theoretical concepts of experimental embryology are presented together with the molecular pathways that underlie them. Section 1 also contains a new chapter on "Cells into Tissues" dealing with the fundamentals of morphogenesis and the underpinning role of cell contacts and the cytoskeleton. In other works, this topic is often fragmented among many individual examples and loses its coherence"-- Provided by publisher.

Summary: Echocardiography remains the most commonly used imaging technique to visualize the heart and great vessels, and this clinically oriented text by Drs. Scott D. Solomon, Justina C. Wu, and Linda D. Gillam helps you make the most of its diagnostic and prognostic potential for your patients. Part of the highly regarded Braunwald's family of cardiology references, Essential Echocardiography expertly covers basic principles of anatomy and physiology, the appearance of normal variants across a wide range of cardiovascular diseases, and the hands-on approaches necessary to acquire and interpret optimal echocardiographic images in the clinical setting.

Contents:
Section I: Principles of ultrasound and instrumentation. Physical principles of ultrasound and generation of images
M-mode imaging
Principles of contrast echocardiography
Principles of transesophageal echocardiography
Principles of three-dimensional ultrasound
Principles and practical aspects of strain echocardiography
Understanding imaging artifacts
Section II: The echocardiographic examination. Principles of transthoracic imaging acquisition: the standard adult transthoracic echocardiographic examination
The transthoracic examination, view by view
Three-dimensional echocardiography: image acquisition
Optimization of the patient and equipment
Utilizing contrast echocardiography in practice
Echo on-call: echocardiographic emergencies
Section III: Assessment of cardiac structure and function. Assessment of left ventricular systolic function
Left ventricular diastolic function
Assessment of right ventricular structure and function
Assessment of the atria
Section IV: Echocardiography for diseases of the myocardium. Acute myocardial infarction
Mechanical complications of myocardial infarction
Long-term consequences and prognosis after myocardial infarction
Echocardiography in heart failure
Dilated cardiomyopathies
Hypertrophic cardiomyopathy
Restrictive and infiltrative cardiomyopathies
Echocardiography in assessment of cardiac synchrony
Echocardiography in assessment of ventricular assist devices
Stress echocardiography and echo in cardiopulmonary testing
Section V: Valvular heart disease. Mitral valve disease
Aortic valve disease
Tricuspid and pulmonic valve disease
Prosthetic valves
Echocardiography in percutaneous valvular intervention
Section VI: Diseases of the pericardium and great vessels. Pericardial disease
Diseases of the aorta
Section vii: diseases of the pulmonary artery and veins
Pulmonary embolism
Pulmonary hypertension
Section VIII: Cardiac masses. Primary and secondary tumors
Identification of intracardiac thrombus
Other cardiac masses
Section IX: Systemic diseases involving the heart. Echocardiography in infective endocarditis
Other systemic diseases and the heart
Echocardiography in malignant disease
Section X: Congenital heart disease in the adult. Atrial septal defect
Ventricular septal defect
Other common congenital defects in adults
Section XI: Miscellaneous topics in echocardiography. Handheld echocardiography
Appropriate use of echocardiography
Echocardiography in the context of other cardiac imaging modalities
Transesophageal echocardiography for cardiac surgery
Appendices. Reference tables
Commonly utilized equations in echocardiography

Contents:
Section I: Basic Perioperative and Critical Care Echocardiography Introduction to Basic Perioperative and Critical Care Echocardiography: Examination, Certification, Indications and Contraindications
Transesophageal Echocardiography: Probe Manipulation, Essential Views
Point-Of-Care Transthoracic Echocardiography: Probe Manipulation, Positioning, Essential Views
Basic Ultrasound Physics, Doppler Ultrasound, and Hemodynamic Assessment
Knobology and Image Optimization
Section II: Echocardiographic Assessment Left Ventricular Systolic Function
Regional Ventricular Function
Mitral Valve
Aortic Valve
Right Heart
Atria
Diastology
Thoracic Aorta
Pericardium
Perioperative Rescue Echocardiography
Imaging Artifacts, Normal Anatomic Variants, and Common Misdiagnoses
Intracardiac Masses, Devices, and Foreign Bodies
Adult Congenital Heart Disease
Section III: Critical Care Ultrasonography Abdominal and Vascular Ultrasound
Volume Assessment and Fluid Responsiveness
Lung Ultrasonography
Shock and Cardiac Arrest
Ultrasound for Vascular Access.

Contents:
A. Section 1: Basic Perioperative Echocardiography
Chapter 1. TEE in Non-Cardiac Surgery: Indications, Contraindications, Probe Manipulation, and Certification
Chapter 2. Transesophageal Echocardiography: Essential Views
Chapter 3. Physics of Ultrasound, Doppler Echocardiography and Hemodynamic Assessment
B. Section 2: Echocardiographic Assessment
Chapter 4. Left Ventricular Systolic Function
Chapter 5. Regional Ventricular Function
Chapter 6. Mitral Valve
Chapter 7. Aortic Valve
Chapter 8. The Right Heart
Chapter 9. Diastology
Chapter 10. Thoracic Aorta
Chapter 11. Rescue Echocardiography
Chapter 12. Imaging Artifacts and Common Misdiagnoses
Chapter 13. Adult Congenital Heart Disease
C. Section 3: Surface Ultrasound
Chapter 14. Transthoracic Echocardiography: The Basic Views
Chapter 15. Ultrasound for Vascular Access.

Summary: "The evaluation of the patient with a non-healing wound consists of three components - subjective history, medical history, and wound assessment. The histories will usually allow the clinician to make a diagnosis of wound etiology, and if not, at least know what needs to be ruled out. They will also give indications as to why the wound is not healing. The wound assessment provides data for objective, measurable outcomes and progress, as well as information on how to treat the wound initially. The most important aspects of treating any wound are to treat all underlying co-morbidities and to address any issues that may be impeding wound healing. Finally, the initial treatment will consist of appropriate debridement of necrotic tissue and application of a dressing that will ensure adequate moisture for wound healing to advance"-- Provided by publisher.

Contents:
Evaluation of the Patient with a Wound
Ischemic Wounds
Venous Wounds
Pressure Injuries/Wounds
Diabetic Foot Ulcers
Burns
Immune-mediated Tissue Injury
Malignant Wounds
Infections
Miscellaneous Wounds.

Summary: This reference for emergency room physicians features step-by-step instructions for nearly 100 adult and pediatric procedures.

Contents:
Section 1. Respiratory / section editor, Leon D. Sanchez
section 2. Cardiac / section editor, Ram A. Parekh
section 3. Trauma / section editor, Kaushal H. Shah
section 4. Vascular / section editor, Bret P. Nelson
section 5. Gastrointestinal / section editor, Josh Quass
section 6. Genitourinary / section editor, Ari M. Lipsky
section 7. Obstetric / section editor, Dara A. Kass
section 8. Neurology / section editor, Jonathan A. Edlow
section 9. Musculoskeletal / section editors, Part A, Natasha Desai ; Part B, Wallace A. Carter ; part C, Moira Davenport
section 10. Soft tissue / section editor, Sanjey Gupta
section 11. Heent / section editor, Joseph Habboushe
section 12. Nerve blocks / section editor, Scott G. Weiner
section 13. Foreign body / section editors, Elan S. Levy and Diana Kim
section 14. Pediatrics / section editor, Louis A. Spina.

Contents:
Diagnosis and classification of mood disorders
Natural course of mood disorders and its treatment
History of lithium treatment
Pharmacology and mechanisms of action
Maintenance treatment with lithium
Treatment of mania with lithium
Treatment of depression with lithium
Suicide prevention with lithium
Other clinical indications of lithium including neuroprotective effects and its potential indications
Lithium in pregnancy and postpartum period
Practical management of lithium
Adverse effects and its management
Other treatments for bipolar disorder and major depression.

Contents:
Section I Anesthesia
Section II Urgent and emergency care
Section III Cardiovascular and respiratory
Section IV Basic dermatology
Section V Aesthetic procedures
Section VI Closure techniques
Section VII Skin surgery
Section VIII Nail procedures
Section IX Gynecology and urology
Section X Gastroenterology
Section XI Eye, ear, nose, and throat procedures
Section XII Musculoskeletal procedures
Section XIII Pediatrics
Section XIV Appendices

Contents:
Understanding health assessment
Interviewing the patient for a health history
Taking a health history
Assessing nutrition and anthropometric measurements
Assessment techniques
General survey and assessing vital signs
Assessing pain
Assessing skin, hair, and nails
Assessing the head, face, mouth, and neck
Assessing the ears
Assessing the eyes
Assessing the respiratory system
Assessing the cardiovascular system
Assessing the abdomen
Assessing the peripheral vascular system and regional lymphatic system
Assessing the musculoskeletal system / Karen L. Gorton and Janice Thompson
Assessing the neurological system / Kim Foisy and Janice Thompson
Assessing the female breasts, axillae and reproductive system / Janice Thompson and Meredith Scannell
Assessing the male breasts and reproductive system
Assessing the anus and rectum
Assessing the newborn / Janice Thompson and Jane Brophy
Assessing the child and adolescent / Cory Ann Boyd and Janice Thompson
Assessing the pregnant woman / Leslie White
Assessing the older adult.

Summary: This book offers an excellent review of the various rheumatological conditions, both common and uncommon, that may present on imaging on a daily basis. The book uses a unique format that will be beneficial for clinicians, radiologists, medical students, and consultant staff. The text is written by both rheumatology and radiology staff to provide a balanced approach. A clinical overview and the common clinical presentations are briefly reviewed for each condition followed by a more detailed discussion of imaging findings produced by the various imaging modalities, including radiographs, ultrasound, MRI, CT, and nuclear medicine. This book details the imaging of normal musculoskeletal anatomy and pathology; discusses image-guided musculoskeletal interventions; and examines disorders such as rheumatoid arthritis, connective tissue disease, osteoarthritis, osteonecrosis, infection-related arthritis, soft tissue calcification, and bone and synovial tumors. Featuring over 600 multi-part, high-resolution images of rheumatic diseases across current imaging modalities, Essential Imaging in Rheumatology offers up-to-date and complete information on the imaging of these disorders.

Contents:
Introduction to Imaging
Arthritis: A Diagnostic Approach
Image Analysis
Image-Guided Interventional Diagnosis and Treatment
Inflammatory Arthritides
Spondyloarthropathy
Connective Tissue Disease
Crystal-Related Disease
Endocrive and Miscellaneous Arthropathies
Osteoarthritis
Metabolic Bone Disease
Osteonecrosis
Imaging in Musculoskeletal Infection
The Diabetic Foot
Spine
Soft Tissue Calcification
Bone and Synovial Tumors
Appendix: Image Scoring Methods in Arthritis.

Summary: The book is a question-and-answer guide to interventional radiology. This pocket resource addresses both general IR and subspecialty topics, providing accurate, on-the-spot answers. Students can read the text from cover to cover to gain a general foundation of knowledge that can be built upon when they begin their rotation or use specific chapters to review a subspecialty before starting a new rotation or joining a new service. The book begins with a general introduction to IR and its common procedures and tools, and is then organized by subspecialties (like vascular disease, oncology, and genitourinary), focusing on common conditions. The books two-column format provides questions on the left and answers on the right to facilitate rapid-fire review that includes many classic images to facilitate pattern recognition skills. This book is an ideal, on-the-spot reference for medical students, residents, and practicing interventional radiologists seeking fast facts on diagnosis and treatment with interventional radiology.

Contents:
SECTION I: Introduction
Using this book
What is Interventional Radiology?
Core principles
SECTION II: Daily Workflow
Role of a sub-intern
Presenting patients
Morning rounds
Afternoon rounds
Taking call
Pre-procedure
SECTION III: The Vascular Suite
Prepping
Running the table
Choice of Access
Seldinger technique
Guidewires
Catheters
Connectors
Balloons
Stents
Embolization
Other
SECTION IV: CT/MRI/US
Procedures
Materials
SECTION V: Vascular Disease
Abdominal aortic aneurysms
Thoracic aortic aneurysms
Angiography
Angioplasty and stenting
Deep vein thrombosis
Mesenteric ischemia
Arteriovenous Malformations
Central Venous Access
Carotid Artery Stenosis
Renovascular Hypertension
Varicose Vein
Vena Cava Filter
Peripheral Artery Aneurysm
Dialysis grafts
SECTION VI: Oncology
Hepatic
Pulmonary
Renal
Other
SECTION VII: Hepatobiliary
Transjugular intrahepatic porotosystemic shunts
Balloon-occluded retrograde transvenous obliteration
SECTION VIII: Genitourinary
Percutaneous nephrostomy
Ureteral Stenting
Uterine fibroid embolization
Prostatic artery embolization
SECTION IX: Neuro
Stroke
Vertebroplasty and kyphoplasty
Pain management
SECTION X: Vascular Emergencies
Embolization
Splenic
Pelvic
Bronchial
Upper gastrointestinal bleeding
Lower gastrointestinal bleeding
Uterine artery embolization
Contrast reactions
SECTION XI: Other
Tubes
Biopsy
New procedures.

Summary: "This book will help students successfully completed their intensive program of study and establish their careers. Chapters will be co-written by current MD-PhD students, recent graduates and established physician-scientists"-- Provided by publisher.

Contents:
Preface
Introduction
Applying for MD-PhD training
Early days in medical school
The transition to graduate school
Transitioning back to medical school
Residency, fellowship, and your first job
Physician-scientist wellness.

Summary: This casebook provides a concise yet comprehensive state-of-the art review of common stomach and small intestine disorders. The casebook is divided into five parts, each of which focuses on a major disorder, symptom, or clinical scenario related to the stomach and small intestine, including dyspepsia, small bowel disorders, nausea and vomiting, chronic abdominal pain, and post-operative GI surgery challenges. Each part is comprised of cases illustrating different aspects of the subject, with each case containing sections on case presentation, objectives, epidemiology and etiology, diagnostic evaluation and treatment, case follow-up, clinical pearls, and Q&A. Some major topics presented in these cases include nausea and vomiting in the pregnant patient, gas-bloat, functional abdominal pain, post-GI surgery complications, and celiac disease and non-celiac gluten sensitivity. Written by internationally renowned experts in the field, Essential Medical Disorders of the Stomach and Small Intestine: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients afflicted with disorders of the stomach and small intestine.

Contents:
Intro
Preface
Contents
Contributors
Part I: Nausea and Vomiting
Chapter 1: Approach to Nausea and Vomiting
Case Study
Objectives
Epidemiology
Pathophysiology
Etiology
Diagnostic Evaluation
Treatment
Clinical Case Study Follow-Up
Self-Test
References
Essential Reading
Chapter 2: Gastroparesis
Case Study
Objectives
Epidemiology
Symptoms
Diagnostic Evaluation
Treatment
Symptom Management
Prokinetics
Prokinetics in Development
Pyloric Interventions
Gastric Electrical Stimulation
Case Study: Follow-Up
Self-Test
References
Essential Reading
Chapter 3: Nausea and Vomiting of Pregnancy and Postoperative Nausea and Vomiting
Case Study 1
Case Study 2
Objectives
Nausea and Vomiting of Pregnancy
Epidemiology
Etiology/Pathophysiology
Diagnosis
Treatment
First-Line Therapy
Second-Line Treatment
Third-Line Treatment
Postoperative Nausea and Vomiting
Epidemiology
Pathophysiology
Etiology
Diagnosis
Treatment
5-Hydroxytryptamine Receptor Antagonists
Corticosteroids
Anticholinergics
Neurokinin-1 Receptor Antagonists
Dopamine Receptor Antagonists
Antihistamines
Other PONV Treatment Options
Case Study: Follow-Up
Self-Test Questions
References
Essential Reading List
Chapter 4: Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome
Case Study
Objectives
Epidemiology
Etiology/Pathophysiology
Symptoms
Diagnostic Evaluation
Treatment
Case Study: Follow-Up
Self-Test
References
Essential Reading
Chapter 5: Chronic Intestinal Pseudo-Obstruction
Case Study
Objectives
Epidemiology
Classification
Etiology and Pathophysiology
Neuropathies
Intestinal Myopathies
Mesenchymopathies
Symptoms
Diagnosis
Treatment
Nutrition Assessment
Oral Diet
Enteral Nutrition Considerations
Parenteral Nutrition Considerations
Medications and Other Therapies
Fecal Transplant
GI Decompression
Small Intestinal Transplantation
Case Study Follow-Up
Self-Test
References
Essential Reading
Part II: Dyspepsia and Other Disorders of Neuromuscular Function
Chapter 6: A Diagnostic Approach to Dyspepsia
Case Study
Objectives
Epidemiology
Etiology and Pathophysiology
Symptoms
Diagnostic Evaluation
Treatment
Case Study: Follow-Up
Self-Test
References
Essential Reading
Chapter 7: Helicobacter pylori and Related Diseases
Case
Objectives
Epidemiology
Etiology and Pathophysiology
Symptoms
Diagnostic Evaluation
Treatment
Case Study: Follow-Up
Self-Test
References
Essential Reading
Chapter 8: Functional Dyspepsia
Case
Objectives
Epidemiology
Etiology and Pathophysiology
Symptoms
Diagnostic Evaluation
Treatment
Helicobacter Pylori
Acid Suppression
Antidepressants
Prokinetics
Further Options
Case Study: Follow-Up
Self-Test
References
Essential Reading
Chapter 9: Rumination Syndrome
Case Study
Objectives
Epidemiology
Etiology and Pathophysiology
Symptoms
Diagnostic Evaluation
Treatment
Case Study: Follow-Up

Summary: "There has been a dramatic explosion of information in the field of neuroscience over the last few decades. This explosion of information has presented a great challenge to those of us who teach neuroscience in terms of synthesizing a coherent approach in which the diverse topics encompassed by neuroscience can be taught in a lucid and effective manner. We met this challenge by designing Essential Neuroscience, a book that considers all of the basic neuroscience topics to allow the students to focus on the essential concepts and facts intrinsic to any given topic without overwhelming them with distracting or confusing extraneous information"-- Provided by publisher.

Contents:
Machine generated contents note: SECTION I Gross Anatomy of the Brain
1. Overview of the Central Nervous System
2. Development of the Nervous System
3. Meninges and Cerebrospinal Fluid
SECTION II The Neuron
4. Histology of the Nervous System
5. Electrophysiology of Neurons
6. Synaptic Transmission
7. Neurotransmitters
SECTION III Organization of the Central Nervous System
8. The Spinal Cord
9. Brainstem I: The Medulla
10. Brainstem II: Pons and Cerebellum
11. Brainstem III: The Midbrain
12. The Forebrain
13. The Cranial Nerves
SECTION IV Sensory Systems
14. Somatosensory System
15. Visual System
16. Auditory and Vestibular Systems
17. Olfaction and Taste
SECTION V Motor Systems
18. The Upper Motor Neurons
19. The Basal Ganglia
20. The Cerebellum
SECTION VI Integrative Systems
21. The Autonomic Nervous System
22. The Reticular Formation
23. The Hypothalamus
24. The Limbic System. Contents note continued: 25. The Thalamus and Cerebral Cortex
26. Blood Supply of the Central Nervous System
27. Vascular Syndromes
28. Behavioral and Psychiatric Disorders.

Contents:
I: Gross anatomy of the brainp
Overview of the central nervous systemp
Development of the nervous systemp
Meninges and cerebrospinal fluid
II: The neuronp
Histology of the nervous system
Electrophysiology of neurons
Synaptic transmission
Neurotransmitters
III: Organization of the central nervous system
The spinal cord
Brainstem I: the medulla
Brainstem II: pons and cerebellum
Brainstem III: the midbrain
The forebrain
The cranial nerves
IV: Sensory systems
Somatosensory system
Visual system
Auditory and vestibular systems
Olfaction and taste
V: Motor systems
The upper motor neurons
The basal ganglia
The cerebellum
VI: Integrative systems
The autonomic nervous system
The reticular formation
The hypothalamus
The limbic system
The thalamus and cerebral cortex
Blood supply of the central nervous system
Vascular syndromes
Behavioral and psychiatric disorders.

Summary: This is the ideal companion for postgraduate pain medicine exams and a comprehensive guide to acute, chronic, and cancer pain management for practising doctors, pain nurses, and allied health professionals

Contents:
-- Preface
1. Anatomy of the female pelvis
2. Conception and implantation
3. Physiological changes in pregnancy
4. Placental and fetal growth and development
5. Perinatal and maternal mortality
6. History taking and examination in obstetrics
7. Normal pregnancy and antenatal care
8. Obstetric disorders
9. Maternal medicine
10. Congenital abnormalities and assessment of fetal wellbeing
11. Management of labour
12. Management of delivery
13. Postpartum and early neonatal care
14. Mental health and childbirth
15. Basic clinical skills in gynaecology
16. Gynaecological disorders
17. Infertility
18. Early pregnancy care
19. Sexual and reproductive health
20. Gynaecological oncology
21. Prolapse and disorders of the urinary tract
Principles of perioperative care
Governance, audit and research
Medicolegal aspects of obstetrics and gynaecology
OSCE stations: Questions
OSCE stations: Answers
Self-assessment: Questions
Self-assessment: Answers --

Summary: This book highlights the advances in essential oil research, from the plant physiology perspective to large-scale production, including bioanalytical methods and industrial applications. The book is divided into 4 sections. The first one is focused on essential oil composition and why plants produce these compounds that have been used by humans since ancient times. Part 2 presents an update on the use of essential oils in various areas, including food and pharma industries as well as agriculture. In part 3 readers will find new trends in bioanalytical methods. Lastly, part 4 presents a number of approaches to increase essential oil production, such as in vitro and hairy root culture, metabolic engineering and biotechnology. Altogether, this volume offers a comprehensive look at what researchers have been doing over the last years to better understand these compounds and how to explore them for the benefit of the society.

Contents:
Intro; Preface; Acknowledgments; Contents; Contributors; Part I: Essential Oils Composition and Why Plants Produce Them;
Chapter 1: Essential Oils; 1.1 Introduction; 1.2 History of Essential Oils; 1.3 Sources of Essential Oils; 1.4 Chemistry of Essential Oils; 1.4.1 Hydrocarbon; 1.4.2 Terpenes; 1.4.3 Alcohols; 1.4.4 Aldehydes; 1.4.5 Acids; 1.4.6 Esters; 1.4.7 Ketones; 1.4.8 Lactones; 1.5 Methods of Extracting Essential Oils; 1.5.1 Maceration; 1.5.2 Cold Pressing; 1.5.3 Solvent Extraction; 1.5.4 Enfleurage; 1.5.5 Hydrodistillation; 1.5.6 CO2 and Supercritical CO2 Extraction 1.5.7 Turbo Distillation Extraction1.5.8 Steam Distillation; 1.6 Analysis of Essential Oils; 1.6.1 Classical Analytical Techniques; 1.6.2 Modern Analytical Techniques; 1.7 Biological Activities of Essential Oils; 1.7.1 Antibacterial Activity; 1.7.2 Antioxidant Activity; 1.7.3 Anti-Inflammatory Activity; 1.7.4 Cancer Chemoprotective Activity; 1.7.5 Cytotoxicity; 1.7.6 Allelopathic Activity; 1.7.7 Repellent and Insecticidal Activity; 1.8 Applications of Essential Oils; 1.8.1 Pharmacology and Medicinal Uses; 1.8.2 Uses in Veterinary Medicine; 1.8.3 Aromatherapy; 1.8.4 Agricultural Uses 1.8.5 Industrial Uses1.9 Essential Oil and Health Fitness; 1.10 Risks and Dangers of Essential Oils; References;
Chapter 2: Factors Influencing the Production and Chemical Composition of Essential Oils in Aromatic Plants from Brazil; 2.1 Introduction; 2.2 Medicinal and Aromatic Plants; 2.3 Essential Oils: Methods of Extraction and Identification; 2.4 Influence of Genetic, Epigenetic, Abiotic, and Biotic Factors on the Production and Chemical Composition of Essential Oils; 2.4.1 Genetic Diversity; 2.4.2 Mineral Nutrition; 2.4.2.1 Biosolids and Plant Growth 2.4.3 Water Stress and Aromatic Species2.4.4 Allelopathy and Aromatic Species; 2.4.5 Seasonality and Edaphoclimatic Factors; 2.5 Biological Activity of the Essential Oil and Isolated Substances; 2.6 Conclusions; References;
Chapter 3: Hedychium Essential Oils: Composition and Uses; 3.1 Introduction; 3.2 Chemical Constituents of Hedychium Essential Oils; 3.3 Antimicrobial Activities; 3.4 Conclusions; References;
Chapter 4: The Essential Oils of the Burseraceae; 4.1 Introduction: Overview of the Burseraceae; 4.2 Tribe Bursereae; 4.2.1 The Genus Bursera; 4.2.2 The Genus Boswellia 4.2.2.1 Traditional Uses of Boswellia4.2.2.2 Ecology of Boswellia; 4.2.2.3 Chemical Ecology of Boswellia; 4.2.3 The Genus Commiphora; 4.2.3.1 Traditional Uses of Commiphora; 4.2.4 The Genus Aucoumea; 4.3 Tribe Canarieae; 4.3.1 The Genus Canarium; 4.3.2 The Genus Dacryodes; 4.3.3 The Genus Santiria; 4.3.4 The Genus Trattinnickia; 4.4 Tribe Protieae; 4.4.1 The Genus Protium; 4.5 Summary and Conclusions; References; Part II: Uses of Essential Oils in Various Industries;
Chapter 5: Essential Oil of Betel Leaf (Piper betle L.): A Novel Addition to the World Food Sector; 5.1 Introduction; 5.2 Origin, Taxonomy, and Nomenclature of Betel Leaf (Piper betle L.).

Contents:
Introduction
Essential oil composition
Toxicity
Kinetics and dosing
The skin
The respiratory system
The cardiovascular system
The urinary system
The digestive system
The nervous system
The reproductive system
Cancer and the immune system
Essential oil profiles
Constituent profiles
General safety guidelines.

Summary: Utilizing a rapid-fire, two-column question and answer format, this is an ideal on-the-spot resource for senior medical students covering a wide range of both general and subspecialty orthopedic topics: anatomy, physiology, presentation and history, pathophysiology, differential diagnosis, physical examination, radiological evaluation, operative and non-operative treatment techniques, surgical complications, rehabilitation and more. With hundreds of high-yield questions and answer items, this quick reference covers orthopedic basics before moving on to detailed sections on the upper and lower extremity, axial skeleton, pediatric orthopedics, and systemic conditions. The straightforward Q & A format allows for either self-testing or quizzing with partners, whether practicing for a board review or studying up in one's spare time. While it can be read cover to cover for a general foundation of knowledge, it can also be referred to selectively before starting a new rotation or seeing a patient with a subspecialty attending. Useful as a companion text to Orthopedic Surgery Clerkship and Orthopedic Surgery Rotation, Essential Orthopedic Review is a handy, pocket-sized resource and review guide that can be used by senior medical students, nursing and PT students, primary care providers, and junior residents in orthopedics and sports medicine.

Summary: Particularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with a strong foundation of facts and data. Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course. This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting. It is ideal for self-learning for the beginning pharmaceutics student, based upon the extensive utilization of figures, tables, and its overview of essential topics in pharmaceutics. Also unique to this text is the integration of case studies based upon modern pharmaceutical products which are designed to reinforce importance pharmaceutical concepts and teach essential skills in literature review and patent searching. Case studies covering all topics covered in the text have been developed by the authors that allow application of the content in the flipped-classroom pharmaceutical course.

Contents:
Preface: Designing a Flipped-Classroom Pharmaceutics Course
Guide to Patent and Literature Searching in Pharmaceutics
Preformulation
Capsules and Tablets
Modified Release Solid Oral Dosage Forms
Solution-Based Dosage Forms and Sterile Products
Suspensions
Emulsions
Ophthalmic Delivery
Nasal Dosage Forms
Topical and Transdermal Dosage Forms
Suppositories and Inserts
Pulmonary Drug Delivery
Regulations in Drug Product Development.

Summary: The basic science important to nuclear imaging, including the nature and production of radioactivity, internal dosimetry and radiation detection and measurement, are presented clearly and concisely. Current concepts in the fields of radiation biology and radiation protection relevant to medical imaging, and a number of helpful appendices complete this comprehensive textbook. The text is enhanced by numerous full color charts, tables, images and superb illustrations that reinforce central concepts. The book is ideal for medical imaging professionals, and teachers and students in medical physics and biomedical engineering. Radiology residents will find this text especially useful in bolstering their understanding of imaging physics and related topics prior to board exams."--Pub. desc.

Contents:
Section I. Basic concepts
II. Diagnostic radiology
Section III. Nuclear medicine
Section IV. Radiation biology and protection
Section V. Appendices.

Contents:
Unipac 1. Medical care of people with serious illness / Ruth M. Thomson, Chirag Rajni Patel, Kate M. Lally.
Unipac 2. Psychiatric, psychological, and spiritual care / Scott A. Irwin, Nathan Fairman, Jeremy M. Hirst, Janine D. Siegel, Lori Montross-Thomas.
Unipac 3. Pain assessment and management / Mellar P. Davis, Shallni Dalal, Harold Goforth, Mary Lynn McPherson, Eric Roeland, Paul A. Sloan
Unipac 4. Nonpain symptom management / Jennifer M. Kapo, Catherine Adams, Ryan M. Giddings-Connolly, Felicia Hui, Andrew T. Putnam, Rebecca Sands, Aleksander Shalshin.
Unipac 5. Communication and teamwork / Lara Michal Skarf, Katie H. Stowers, Andrew Thurston
Unipac 6. Ethical and legal practice / Elizabeth K. Vig, Christina L. Bell, Judith C. Ahronheim, Caroline A. Vitale.
Unipac 7. Pediatric palliative care and hospice / Meaghann Weaver, Brian Carter, Patricia Keefer, David N. Korones, Elissa G. Miller. Unipac 8. COPD, heart failure, and renal disease / Vincent Jay Vanston, Grace Brooke Huffman, Nina O'Connor, Niharlka Ganta.
Unipac 9. HIV, dementia, and neurological conditions / Christopher M. Blais, Jennifer Gabbard, Sonia Malhotra, Susan E. Nelson.

Summary: "This text is a user-friendly guide to performing 77 clinical procedures, ranging from those commonly performed to those infrequently called upon when minutes count in emergency, urgent, and primary care settings. This heavily updated third edition includes current and comprehensive text, graphic, and video instruction on the use of bedside ultrasound for procedural guidance in order to increase procedural accuracy and mitigate complications. Edited and written by academically accomplished physicians, physician assistants, and nurse practitioners, an interprofessional approach to the performance of procedures is highlighted throughout the book. Procedures are consistently formatted and presented in clear language with step-by-step detail organized by system-specific categories for easy access to information. Each procedure includes background considerations, indications & contraindications for performing the procedure, technique for safe and correct performance, special considerations, complications, post-procedure considerations, and patient education points. Original photos, videos, high quality sonographic footage, line drawings, and tables reinforce the guidelines and procedures. Abundant "Clinical Pearls" throughout the manuscript offer practical applications of key information representing years of clinical technical experience. Extensive references at the end of each chapter further enhance the book's utility"-- Provided by publisher.

Contents:
Stress, Skin, & Beauty : The Basic Science Base / Mary D. Sun and Evan A. Rieder
The Science and Psychology of Beauty / Vanessa Cutler
The Use of Cosmetic Products / Zoe Diana Draelos
An Approach to Cosmeceuticals / Emily C. Milam and Evan A. Rieder
Aesthetic Assessment & Theories of Beauty / Michael Abrouk, Leslie Harris, and Jill S. Waibel
The Cosmetic Consultation : Anatomy & Psychology
The Female Patient / Eagan Zettlemoyer and Noelle S. Sherber
The Cosmetic Consultation : Anatomy & Psychology
The Male Patient / Kalee Shah, Nathaniel Lampley III, Anthony Rossi
The Cosmetic Consultation : Anatomy & Psychology
The Transgender Patient / Brian Ginsberg
Aesthetic Interventions and the Perception of the Self : Quality of Life and Patient Reported Outcomes / Danielle Weitzer and Rick Fried
Aesthetic Interventions and the Perception of Others : Observer Reported Outcomes / Payal Shah and Evan A. Rieder
Botulinum Toxins: Beauty, Psychology, & Mood in the Cosmetic Patient / Catherine Pisano, Jason Reichenberg, Michele Magid
Boundaries / Evan A. Rieder and Jacob Sacks
Difficult Personalities and Personality Disorders in the Cosmetic Clinic / Mio Nakamura and John Koo
Normative Discontent and Social Dysmorphia in the Cosmetic Patient / Susruthi Rajanala and Neelam Vashi
Obsessive Compulsive Disorder & Body Dysmorphic Disorder in the Cosmetic Patient / Mary D. Sun and Evan A. Rieder
Protecting Your Patients : When Enough Is Enough
Saying No and Satisfying the Dissatisfied Patient / Jacqueline Watchmaker, Prasanthi Kandula, and Michael S. Kaminer
Protecting Yourself : Legal Issues in Aesthetic Medicine
Informed Consent, Discharge, & Lawsuits / Brian P. Hibler and Matthew M. Avram
Psychological Tools to Assist your Practice : Progressive Muscle Relaxation, Deep Abdominal Breathing, Mindfulness, & Guided Imagery / Nicholas Brownstone, Bridget Myers, and Josie Howard
Hypnotic Techniques for the Aesthetic Practitioner / Philip D. Shenefelt
Acceptance & Commitment Therapy in the Aesthetic Setting / Vanessa Cutler
Behavioral Modification for Acne Excoriee & Skin Picking / Karen M. Ong, Mary Sun, and Evan A. Rieder
Motivational Interviewing for Identification & Triage of the Cosmetic Addict / Rick Fried and Evan A. Rieder
Beauty through the Life Continuum / Doris Day.

Contents:
Introduction to radiology
The circulatory system: the heart and great vessels
The respiratory system
The digestive system
The urinary tract
The acute abdomen
The reproductive system
The musculoskeletal system
Neuroimaging
Pediatric radiology.

Summary: The book is an on-the-spot reference for residents and medical students seeking diagnostic radiology fast facts. Its question-and-answer format makes it a perfect quick-reference for personal review and studying for board examinations and re-certification. Readers can read the text from cover to cover to gain a general foundation of knowledge that can be built upon through practice or can use choice chapters to review a specific subspecialty before starting a new rotation or joining a new service. With hundreds of high-yield questions and answer items, this resource addresses both general and subspecialty topics and provides accurate, on-the-spot answers. Sections are organized by subspecialty and body area, including chest, abdomen, and trauma, and chapters cover the anatomy, pathophysiology, differential diagnosis, hallmark signs, and image features of major diseases and conditions. Key example images and illustrations enhance the text throughout and provide an ideal, pocket-sized resource for residents and medical students. -- Provided by publisher.

Contents:
Introduction
SECTION I: Imaging Modalities
Radiography
Computed Tomography
Ultrasonography
Magnetic Resonance Imaging
Fluoroscopy
Nuclear Medicine
SECTION II: Chest
Technical adequacy of chest radiograph
The Normal Frontal Chest Radiograph
Normal Pulmonary Vasculature
The Normal Lateral Chest Radiograph
Normal CT Anatomy of the Chest
Normal CT Anatomy of the Lungs
The Fissures
Classifying Parenchymal Lung Disease
Characteristics of Airspace Disease
Some Causes of Airspace Disease
Characteristics of Interstitial Lung Disease
Some Causes of Interstitial Lung Disease
Atelectasis of the Entire Lung
Massive Pleural Effusion
Pneumonia of an Entire Lung
Post-pneumonectomy
What is Atelectasis?
Types of Atelectasis
Patterns of Collapse in Lobar Atelectasis
How Atelectasis Resolves
Normal Anatomy and Physiology of the Pleural Space
Modalities for Detecting Pleural Effusions
^Causes of Pleural Effusions
Types of Pleural Effusions
Side-Specificity of Pleural Effusions
General Characteristics of Pneumonia
Patterns of Pneumonia
Lobar Pneumonia
Segmental Pneumonia (Bronchopneumonia)
Interstitial Pneumonia
Round Pneumonia
Cavitary Pneumonia
Aspiration
Localizing Pneumonia
How Pneumonia Resolves
Pneumothorax
Pneumomediastinum
Pneumopericardium
Subcutaneous Emphysema
Endotracheal and Tracheostomy Tubes
Intravascular Catheters
Cardiac Devices
Pacemaker, AICD, IABP
GI Tubes and Lines
Nasogastric Tubes, Feeding Tubes
Esophagus
Mediastinal Masses
Anterior Mediastinum
Middle Mediastinal Masses
Posterior Mediastinal Masses
Solitary Nodule/Mass in the Lung
Bronchogenic Carcinoma
Metastatic Neoplasms in the Lung
Pulmonary Thromboembolic Disease
Chronic Obstructive Pulmonary Disease
Blebs and Bullae, Cysts and Cavities
Bronchiectasis
Normal Cardiac CT Anatomy
^Uses of Cardiac CT
Cardiac MRI
Enlarged Cardiac Silhouette
Pericardial Effusion
Extra-cardiac Causes of Apparent Cardiac Enlargement
Identifying Cardiac Enlargement on an AP Chest Radiograph
Cardiomegaly on the Lateral Chest Radiograph
Non-cardiogenic Pulmonary Edema
General Considerations
Non-cardiogenic Pulmonary Edema
Imaging Findings
Differentiating Cardiac from Non-cardiac Pulmonary Edema
Hypertensive Cardiovascular Disease
Mitral Stenosis
Pulmonary Arterial Hypertension
Aortic Stenosis
Cardiomyopathy
Aortic Aneurysms
General Considerations
Thoracic Aortic Aneurysm
Thoracic Aortic Dissection
Coronary Artery Disease
SECTION III: Abdomen
Conventional Radiography
What to Look For
Normal Bowel Gas Pattern
Normal Fluid Levels
Differentiating Large from Small Bowel
Acute Abdominal Series: the Views and What They Show
Calcifications
Organomegaly
Abdominal CT: General Considerations
^Abnormal Gas Patterns
Laws of the Gut
Functional Ileus: Localized Sentinel Loops
Functional Ileus: Generalized Adynamic Ileus
Mechanical Obstruction: Small Bowel Obstruction
Mechanical Obstruction: Large Bowel Obstruction (LBO)
Volvulus of the Colon
Intestinal Pseudo-obstruction (Ogilvie Syndrome)
Signs of Free Intraperitoneal Air
Air Beneath the Diaphragm
Visualization of Both Sides of the Bowel Wall
Visualization of the Falciform Ligament
Causes of Free Air
Signs of Extra-peritoneal Air (Retroperitoneal Air)
Causes of Extra-peritoneal Air
Signs of Air in the Bowel Wall
Causes and Significance of Air in the Bowel Wall
Signs of Air in the Biliary System
Causes of Air in the Biliary System
Stomach and Duodenum
Duodenal Ulcer
Small and Large Bowel
Large Bowel
Pancreas
Hepatobiliary Abnormalities
Space-Occupying Lesions of the Liver
Biliary System
Urinary Tract
Pelvis
Urinary Bladder
Adenopathy
^SECTION IV: Calcifications
Patterns of Calcification
Rim-like Calcification
Linear or Track-like Calcification
Lamellar or Laminar Calcification
Cloudlike, Amorphous, or Popcorn Calcification
Location of Calcification
SECTION V: Trauma
Chest Trauma
Rib Fractures
Pulmonary Contusions
Pulmonary Lacerations (Hematoma or Traumatic Pneumatocele)
Aortic Trauma
Abdominal Trauma
Pelvic Trauma
SECTION VI: Musculoskeletal
Abnormalities of Bone Density
Normal Bone Anatomy
The Effect of Bone Physiology on Bone Anatomy
Generalized Increase in Bone Density
Focal Increase in Bone Density
Generalized Decrease in Bone Density
Focal Decrease in Bone Density
Pathologic Fractures
Acute Fracture
Dislocations and Subluxations
How Fractures are Described
by the Number of Fracture Fragments
How Fractures are Described
by the Direction of the Fracture Line
^How Fractures are Described
by the Relationship of One Fracture Fragment to Another
How Fractures are Described
by the Relationship of the Fracture to the Atmosphere
Avulsion Fractures
Stress Fractures
Common Fracture Eponyms
Some Easily Missed Fractures or Dislocations
Fracture Healing
Anatomy of a Joint
Classification of Arthritis
Hypertrophic Arthritis
Erosive Arthritis
Infectious Arthritis
SECTION VII: Neuro
The Normal Spine
Back Pain
Malignancy Involving the Spine
MRI in Metastatic Spine Disease
Spinal Trauma
Normal Brain Anatomy
MRI and the Brain
Head Trauma
Intracranial Hemorrhage
Diffuse Axonal Injury
Increased Intracranial Pressure
Stroke
Ruptured Aneurysms
Hydrocephalus
Cerebral Atrophy
Brain Tumors
Other Diseases
Neuroimaging Terminology
SECTION VIII: Pediatrics
Newborn Respiratory Distress
Childhood Lung Disease
Soft Tissues of the Neck
Ingested Foreign Bodies
^Other Diseases
SECTION IX: Ultrasonography and Magnetic Resonance Imaging
How US Works
Doppler Ultrasonography
Adverse Effects or Safety Issues
Medical Uses of Ultrasonography
How Magnetic Resonance Imaging Works
Hardware That Makes Up an MRI Scanner
What Happens Once Scanning Begins
How Can You Identify a T1-Weighted or T2-Weighted Image?
MRI Contrast Agents: General Considerations
MRI Safety Issues
Diagnostic Applications of MRI .

Contents:
Introduction to respiratory medicine
Embryology, anatomy and physiology of the lung
Drug and pharmacology of the lung
Common respiratory investigations
Common respiratory presentations
Obstructive airways disease
Diffuse parenchymal lung disease
Respiratory infections
Lung cancer
Pleural disease
Vasculitides
Suppurative lung disease
Respiratory failure
Sleep disorders
Occupational, environmental and recreational lung disease
Disorders of the mediastinum
Acute lung injury and acute respiratory distress syndrome.

Summary: This book critically reviews 75 important published papers that influence the practice of geriatric psychiatry. This book will assist anyone who is interested in the care of older adults with psychiatric disorders. It was written by thought leaders who shape the way geriatric psychiatry is currently practiced in the United States. All the major psychiatric disorders in later life are covered including anxiety disorders, bipolar disorders, depressive disorders, neurocognitive disorders, psychotic disorders, sleep disorders, and substance use disorders. It also reviews important studies on suicides in late life and interventional procedures in geriatric psychiatry like the ECT, and also evaluates the adverse effects of psychotropic medications on older adults with psychiatric disorders. The editors of the book along with input from members of the teaching and training committee of the American Association for Geriatric Psychiatry (AAGP) have chosen 75 published papers from the field of geriatric psychiatry that they believe provides the highest knowledge-yield/impact for practicing clinicians and educators in the field of geriatric mental health. The AAGP is a national association that represents and serves its members and the field of geriatric psychiatry. These 75 papers are critically appraised by the members of AAGP using a standardized format and a summary of these papers and their practical application is provided by these experts. This information can be used by anyone who wants to learn about the field of geriatric psychiatry.

Contents:
Section 1: Adverse effects of medications
Do atypical antipsychotics cause stroke?
Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials
Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons
The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials
Do antipsychotics lead to cognitive impairment in dementia? A meta-analysis of randomised placebo-controlled trials
A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias
Section 2: Anxiety Disorders
Treatment of panic disorder in older adults: a pilot study comparison of alprazolam, imipramine, and placebo
Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies
Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial
Meta-analysis Comparing Different Behavioral Treatments for Late-Life Anxiety
Cognitive Behavior Therapy for Generalized Anxiety Disorder Among Older Adults in Primary Care: A Randomized Clinical Trial
Stepped-care prevention of anxiety and depression in late life: a randomized controlled trial
A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder
Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults
A meta-analysis of cognitive functioning in older adults with PTSD
Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis
Section 3: Bipolar Disorder
A Pilot Study of Standardized Treatment in Geriatric Bipolar Disorder
Differences in clinical features and mental health service use in bipolar disorder across the lifespan
Effect of antidepressant use on admissions to hospital among elderly bipolar patients
GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder
History of Bipolar disorder and the risk of dementia: A systematic review and meta-analysis
Section 4. Delirium
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Delirium in elderly patients and the risk of post discharge mortality, institutionalization, and dementia: a meta-analysis
Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis
Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis
Interventions for preventing delirium in older people in institutional long‐term care
Section 5: Depressive Disorders
Nortriptyline and Interpersonal Psychotherapy as Maintenance Therapies for Recurrent Major Depression. A Randomized Controlled Trial in Patients Older Than 59 Years
Continuation treatment of delusional depression in older adults
Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
Remission in Depressed Geriatric Primary Care Patients: A Report from the PROSPECT Study
Executive dysfunction and the course of geriatric depression
Maintenance Treatment of Major Depression in Old Age
Placebo-Controlled Study of Relapse Prevention With Risperidone Augmentation in Older Patients with Resistant Depression
Efficacy of Second-Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence
A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
Speed of remission in elderly patients with depression: electroconvulsive therapy v. medication
A systematic review and meta-analysis of psychotherapy for late-life depression
A novel strategy for continuation ECT in geriatric depression: phase 2 of the PRIDE Study
Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study
Improvement in Depression is Associated with Improvement in Cognition in Late-Life Psychotic Depression
Section 6: Electroconvulsive Therapy
Continuation/Maintenance Treatment with Nortriptyline Versus Combined Nortriptyline and ECT in Late-Life Psychotic Depression: A Two-Year Randomized Study
Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia
Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study
Electroconvulsive Therapy and Risk of Dementia-A Nationwide Cohort Study in Taiwan
Section 7: Grief
Treatment of complicated grief in elderly persons: a randomized clinical trial
Section 8: Pain Disorders
Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-Analysis
Section 9: Psychotic Disorders
A Randomized, Controlled Trial of Cognitive Behavioral Social Skills Training for Middle-Aged and Older Outpatients with Chronic Schizophrenia
Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with six-month open-label extension
Antipsychotic treatment for elderly people with late-onset schizophrenia
Schizophrenia and risk of dementia: A meta-analysis study
Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial
Section 10: Neurocognitive Disorders
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis
Depression and risk for Alzheimer disease: Systematic review, Meta-analysis, and Metaregression analysis
Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease
Predictors of progression from mild cognitive impairment to Alzheimer disease
Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis
Personality and risk of Alzheimer's disease: New data and meta-analysis
Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis
Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis
Meta-analysis of modifiable risk factors for Alzheimer's disease
Memantine for Alzheimer's Disease: An Updated Systematic Review and Meta-analysis
Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis
Pharmacological interventions for apathy in Alzheimer's disease
Section 11: Sleep Disorders
Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial
Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial
Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials
Cognitive behavior therapy for older adults with insomnia and depression: a randomized controlled trial in community mental health services
Section 12: Suicides
Medical Illness and the Risk of Suicide in the Elderly
The Risk of Suicide with Selective Serotonin Reuptake Inhibitors in the Elderly
Section 13: Substance Use Disorders
Naltrexone as an Adjunctive Treatment for Older Patients with Alcohol Dependence
Older adult patients with both Psychiatric and Substance abuse disorders: Prevalence and Health service use
Five-year alcohol and drug treatment outcomes of older adults versus middle-aged and younger adults in a managed care program
Treatment of Late-Life Depression Complicated by Alcohol Dependence
Screening and Brief Intervention for Substance Misuse Among Older Adults: The Florida BRITE Project.

Summary: This text serves as a high-yield review of spinal cord injury medicine in a multiple choice question-based format. The content covered reflects key topics relevant to clinical practice and subspecialty certification through the American Board of Physical Medicine and Rehabilitation (ABPMR) Spinal Cord Injury (SCI) Medicine examination. The 22 chapters are arranged topically to address the full scope of information relevant to the field of spinal cord injury medicine. Included with each question is a corresponding in-depth explanation, as well as pertinent references to supporting literature. The questions and educational explanations are written by leading experts in the field of spinal cord injury medicine and are designed to be board-relevant in both content and style. This question bank should be of use to anyone wishing to test and expand their knowledge of spinal cord injury medicine, including therapists, medical students, residents, fellows, and attending physicians of any specialty.

Contents:
Introduction
Epidemiology, Risk Factors and Prevention of Spinal Cord Injury
Anatomy, Physiology and Imaging of the Spinal Cord
Assessment, Classification and Prognosis in Spinal Cord Injuries
Acute Evaluation and Management of Spinal Cord Injuries
Cardiovascular Issues in Spinal Cord Injury
Pulmonary changes After Spinal Cord Injury
Gastrointestinal Disorders in Spinal Cord Injury
Genitourinary Issues in Spinal Cord Injury
Sexuality and Reproductive Health after Spinal Cord Injury
Musculoskeletal Issues in Spinal Cord Injury
Neurological Complications of Spinal Cord Injury
Pressure Injuries
Pain and Spinal Cord Injury
Nutrition, Endocrine, and Immune Function
Psychological Disorders for Individuals with Spinal Cord Injuries
Rehabilitation of Spinal Cord Injuries
Non-Traumatic Spinal Cord Injury
Pediatric Spinal Cord Injury
System Based Practice and Ethical Considerations Related to Spinal Cord Injuries
Community Living with Spinal Cord Injuries.

Summary: The ultimate resource for learning and mastering minimally invasive spine surgery techniques An estimated 1.5 million instrumented spinal procedures are performed every year in the US. The majority of decompressions and about 50% of fusion procedures can be performed completely or partially using minimally invasive spine surgery (MISS) techniques. The full potential of MISS techniques has yet to be realized. Essential Step-by-Step Techniques for Minimally I.

Contents:
Exploratory laparotomy: laparoscopic
Exploratory laparotomy: open
Peritoneal dialysis catheter insertion
Peritoneal lesion: biopsy
Inguinal and femoral hernia: laparoscopic repair
Inguinal and femoral hernia: open repair
Ventral hernia: laparoscopic repair
Ventral hernia: open repair
Cholecystectomy with or without cholangiography: laparoscopic
Cholecystectomy with or without cholangiography: open
Hepatic biopsy: laparoscopic
Hepatic biopsy: open
Splenectomy: laparoscopic
Splenectomy: open
Antireflux procedure: laparoscopic
Gastrostomy: open
Gastrostomy: percutaneous endoscopic
Adhesiolysis: laparoscopic
Adhesiolysis: open
Feeding jejunostomy: laparoscopic
Feeding jejunostomy: open
Ileostomy
Ileostomy closure
Small intestinal resection: open
Appendectomy: laparoscopic
Appendectomy: open
Colectomy, partial: laparoscopic
Colectomy, partial: open
Colostomy
Colostomy closure
Anal fistulotomy/seton placement
Anal sphincterotomy: internal
Anorectal abscess: drainage
Banding for internal hemorrhoids
Hemorrhoidectomy
Perianal condylomas: excision
Bronchoalveolar lavage
Bronchoscopy
Colonoscopy
Esophagogastro?duodenoscopy (EGD)
Laryngoscopy
Proctoscopy
Axillary sentinel lymph node biopsy
Axillary lymphadenectomy
Breast biopsy with or without needle localization
Breast cyst: aspiration
Duct excision
Mastectomy: modified radical
Mastectomy: partial
Mastectomy: simple
Parathyroidectomy
Thyroidectomy: partial or total
Melanoma: wide local excision
Pilonidal cystectomy
Sentinel lymph node biopsy for melanoma
Skin/soft tissue lesions: excisional and incisional biopsy
Soft tissue infections: incision, drainage, debridement
Airway management/ventilator management
Arterial catheter placement
Central venous catheter placement
Compartment pressures (abdomen, extremity): measurement
Defibrillation and cardioversion
Endotracheal intubation
Enteral feeding tube placement
Oxygen administration devices
Paracentesis
Pulmonary artery catheter placement
Thoracentesis
Ultrasound use for intravascular access
Urinary catheterization
Focused abdominal sonography for trauma (FAST)
Gastrointestinal tract injury: operation
Temporary closure of the abdomen
Wounds, major: debride/suture
Amputations: lower extremity
Carotid endarterectomy
Embolectomy/thrombectomy: arterial
Vena cava filter: insertion
Venous insufficiency/varicose veins: operation
Arteriovenous access: revision
Arteriovenous graft/fistula
Percutaneous vascular access
Venous access devices: insertion
Chest tube placement and management
Inguinal hernia repair
Umbilical hernia repair
Skin grafting
Lymph node biopsy
Tracheostomy.

Contents:
Basic epidemiology of infectious diseases / Mark J. Sotir and David O. Freedman
Basic epidemiology of non-infectious diseases / Richard C. Franklin and Peter A. Leggat
Pre-travel health risk assessment / Peter A. Leggat and Jane N. Zuckerman
Setting up a travel clinic
Marc T.M. Shaw and Claire S. Wong
Travel medicine resources / Peter A. Leggat, Gary W. Brunette, Gilles Poumerol and Jane N. Zuckerman
Travellers' diarrhoea / Charles D. Ericsson
Vector borne diseases / Annelies Wilder-Smith
Yellow fever / Mark D. Gershman and J. Erin Staples
Malaria / Tomas Jelinek
Respiratory disease and travel / Regina Larocque and Edward T. Ryan
Sexually transmitted infections in travellers / Alberto Matteelli, Anna Cristina Carvalho and Patricia Schlagenhauf
Tropical skin infections / Fransisco Vega-Lopez and Sara Ritchie
Rabies / Mary Warrell
Vaccine-preventable disease / Joseph Torresi, Abinash Virk and Jane N. Zuckerman
Women's health and travel / I. Dale Carroll
Children's health and travel / Karl Newman and Phil Fischer
Travelers with underlying medical conditions / Anne McCarthy and Kathy Suh
The older traveler and traveling with disability / Kathy Suh and Anne McCarthy
Visiting friends and relatives / Karin Leder and Sarah McGuinness
Migrants, refugees and travel medicine / Louis Loutan
Study-abroad programs : student health and safety issues / Gary Rhodes and Gary W. Brunette
Humanitarian aid workers, disaster relief workers, and missionaries / Brian D. Gushulak and Douglas W. MacPherson
Long-term travelers / Claire Davies and Ted Lankester
Aviation and travel medicine / Michael Bagshaw, Ian Cheng and Robert Bor
Expedition and wilderness medicine / Sean Hudson, Will Smith, David Shlim, Caroline Knox, Karen Marienau
Scuba and diving medicine / Karen J. Marienau
Venomous and poisonous animals and toxins / Mark A. Read
Cruise ships and travel medicine / Sally S.J. Bell and Eilif Dahl
Mass gatherings and travel medicine / Joanna Gaines and Gary W. Brunette
Emergency care whilst abroad / Peter A. Leggat and Marc T.M. Shaw
The returning traveller / Tamar Lachish, Fons Van Gompel and Eli Schwartz.

Summary: This practical, concise guide discusses how to distinguish different types of tremor and make the diagnosis of essential tremor.℗ℓ Written in an easy-to-read format, this book summarises other conditions that may be confused with essential tremor and details all current treatment options for this condition, including medications, surgery and non-invasive alternatives. Examination techniques for patients with a tremor complaint are described, some of which may be novel to the general practitioner, and case studies full of diagnostic and examination pearls are provided.℗ℓ℗ℓ℗ℓ Essential Tremor in Clinical Practice is an updated version of Abdul Qayyum Ranaℓ́ℓs previous book, An Introduction to Essential Tremor. Busy clinicians, including internists, general and family practitioners, and geriatricians will benefit from this short yet comprehensive, clinically focussed volume.

Contents:
What is Tremor?
What is Essential Tremor?.- Clinical Approach to Essential Tremor
Diagnosis of Essential Tremor
Treatment of Essential Tremor
Case Studies
Essential Tremor: A Short History
Resources for Essential Tremor.

Summary: This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.

Contents:
Part 1. Introduction
Chapter 1. History of Tuberculosis
Chapter 2. Mycobacterium tuberculosis: the organism, genomics and evolution
Chapter 3. Pathogenesis and immunology of TB
Chapter 4. Basic and descriptive epidemiology of TB
Chapter 5. TB WHO recommended strategies and Global Health perspectives (and exercise/country examples)
Part 2. Prevention
Chapter 6. Vaccines
Chapter 7. Latent TB infection diagnosis and treatment
Chapter 8. Infection Control (and exercise). Part 3. Diagnosis
Chapter 9. TB Clinical presentation and differential diagnosis
Chapter 10. Laboratory diagnosis of TB (including MDR)
Chapter 11. Radiology in the diagnosis of TB How to read a chest x-ray
IV. Treatment
Chapter 12. Rationale for chemotherapy (and exercise)
Chapter 13. Anti-TB drugs and adverse events
Chapter 14. Treatment of drug-susceptible TB
Chapter 15. Surgery and TB
Chapter 16. How to design the regimen for drug-resistant TB (and clinical cases)
Chapter 17. The shorter regimen for MDR-TB
Chapter 18. Monitoring treatment: clinical and programmatic approach for TB and DR-TB
Chapter 19. Adherence
Chapter 20. TB Patient-centred care
Part 5. Risk factors, risk groups, challenges
Chapter 21. TB, alcohol, smoking and diabetes. Chapter 22. TB and prisons
Chapter 23. TB and migration
Chapter 24. The TB/HIV association
Chapter 25. Childhood TB
Chapter 26. Tuberculosis and women (risk factors, pregnancy, access to services and gender issues)
Chapter 27. TB in the elderly
Chapter 28. Extra-pulmonary TB
Chapter 29. Renal and hepatic failure and tuberculosis
Chapter 30. TB Rehabilitation and palliative care
Chapter 31. Post TB infections
Part 6. Public Health
Chapter 32. The national TB programme: role and functions (and exercise)
Chapter 33. National TB Strategic Planning (and exercise)
Chapter 34. Active case finding and hard-to-reach TB groups
Chapter 35. Managing TB outbreaks in low-incidence settings (and exercise)
Part 7. Global Health
Chapter 36. The global TB burden
Chapter 37. A multi-sectorial approach to tuberculosis control and elimination in the era of the UN Sustainable Development Goals
Chapter 38. One Health--approach to zoonotic tuberculosis. The burden of zoonotic tuberculosis in the world
Chapter 39. Health systems and TB control
Chapter 40. The global and individual economics of TB
Part 8. Research
Chapter 41. An overview of research priorities in TB
Chapter 42. Priority areas for TB vaccines
Chapter 43. Priority areas for TB diagnosis
Chapter 44. Priority areas for latent infection
Chapter 45. Priority areas for TB treatment
Chapter 46. Operational Research.

Summary: Resource ordered for the Diagnostic Medical Sonography program 105262 and Radiography 105261 program.

Contents:
Introduction
Basic Ultrasound Physics
Back
Upper Limb
Lower Limb
Thorax: Chest Wall and Pleura
Heart
Abdomen
Neck, Face, Eye
Femaile Pelvis
Male Pelvis
Focused Assessment with Sonography for Trauma (FAST)
Multiple-Choice Questions.

Summary: E-FAST (extended focused assessment by sonograpy for trauma) represents the basic ultrasonographic approach to any trauma patient. Identification or exclusion of free fluid and air in the abdominal and thoracic cavities plays a pivotal role in deciding the immediate diagnostic and therapeutic path. Learning E-FAST is mandatory for all acute care surgeons and all physicians involved in trauma management. The structure of the book and its practical approach will make it an easy-to-consult and quick reference tool for beginners and a useful support for more experienced professionals.

Contents:
Foreword
Preface
1. Basic physics, instrumentation and knobology
2. E-FAST protocol: Introduction and focused questions
3. Abdominal views: Anatomy, Techniques, Scanning tips and tricks, abnormal images
4.Thoracic views: Anatomy, Techniques, Scanning Tips and Tricks, Abnormal Images
5. Including EFAST in Trauma Algorithm: When? What to do next?
6. The role of EFAST in Comprehensive US Trauma Management (ABCDE-US) Facing Clinical Scenarios
7. Pre-Hospital US in Trauma: Role and Tips
8. CEUS-FAST: What is it? .

Summary: When the COVID- 19 pandemic occurred, all the main communication systems of medical research have undergone an epochal change. Many online journals and magazines have tried to publish inherent works of this specific problem as soon as possible, soliciting and preferring them to others, thus changing the system of free acceptance of scientific works once. Moreover, the way to communicate these works has no longer occurred through standard Scientific Congresses but with other systems, websites/streaming and webinars or virtual conferences. Now there is something systematic missing, which foresees that this may last in the future, in the post COVID-19 era (AC): the communication system of the medical sciences will be different from now on. There will be far fewer classical-style conferences like the ones so popular before COVID-19 outbreak (BC) but there will be more webinars, in streaming and virtual conferences. This new book fits well in this period, creating a bridge between those who do research, how it is communicated, what are the classic communication methods and what is all the necessary background to communicate with new tools. The book idea is based on the legacy left by Michael Faraday, the famous American chemist, who sensed how communicating what happens in science can make the difference between the success and failure of the research itself.

Contents:
The Island Of Research (Do Not Block The Path Of Enquiry)
Big Data, Metanalysis And Sistematic Reviews : The Jungle Of Statistics
Essentials On Writing A Paper For A Peer Reviewed Journal
The Value Of The Websites And Online Journals
Ways To Implement Your Key Messages
The Classical Meetings And Congresses
The New Ways To Communicate Your Research: Webinars And Beyond
The Virtual Theatre : The Lure, The Title, The Scene, The Backstage, The Space
The World Of Audience : Listeners Or Gazers, Learned Or Unlearned
Connect And Be Understood
Narrative Science And Medicine
The Legacy Of Michael Faraday.

Summary: Patient safety and quality improvement in health care remain a global priority. Subpar performance in health care, however, is still common more than a decade after the christening of patient safety in Africa. The core principle of safety and quality improvement systems is to identify and assess the root cause of failures in order to learn from them and devise a means to improve and to avoid recurrence. This book is designed to encourage, facilitate and empower healthcare workers in the development and implementation of strategically driven patient safety and quality improvement initiatives for safer healthcare systems and healthcare facilities in low- and middle-income countries (LMICs) of Africa.^It also highlights some of the profound challenges and barriers to designing and implementing patient safety and quality improvement interventions or programmes in the region and reiterates the need to remain focused and determined to work out solutions with confidence and overcome these barriers. In the book, chapters highlight six essential components crucial for achieving evolutionary progress in safety and quality improvement in a healthcare system: Standard operating procedure Audit Research Safety management Quality management Evaluation Practical steps in planning and conducting these six essential components are outlined with some specific features to aid learning and facilitate their implementation. The authors have experience and expertise in the medical practice gained in Africa and a decade of knowledge and experience from consultancy work in safety and quality improvement in health care within and outside the region.^Essentials for Quality and Safety Improvement in Health Care: A Resource for Developing Countries is authored for both medical professionals and those from other professions who are interested in and enthusiastic about patient safety and healthcare quality and therefore willing to build a career in this field. It is relevant to all health institutions, health and non-health workers, and can be used as a checklist while rendering quality and safe health care.

Contents:
Chapter 1. Concept of Quality and Safety Improvement in Health Care
Chapter 2. Standard Operating Procedure
Chapter 3. Audit
Chapter 4. Research
Chapter 5. Safety Management
Chapter 6. Quality Management
Chapter 7. Evaluation.

Contents:
Applied anatomy & Surgical Approaches to the Elbow
Lateral Elbow Pain
Medial Elbow Pain
Distal Humerus Fractures
Fractures and Dislocations of the Proximal Ulna & Radial head
Elbow Stiffness
Elbow Instability
The Arthritic Elbow
Tendon Injuries
Safety in Elbow Surgery: From Open to Arthroscopy.

Summary: This textbook teaches the principles and applications of fermentation technology, bioreactors, bioprocess variables and their measurement, key product separation and purification techniques as well as bioprocess economics in an easy to understand way. The multidisciplinary science of fermentation applies scientific and engineering principles to living organisms or their useful components to produce products and services beneficial for our society. Successful exploitation of fermentation technology involves knowledge of microbiology and engineering. Thus the book serves as a must-have guide for undergraduates and graduate students interested in Biochemical Engineering and Microbial Biotechnology.

Contents:
1. Fermentation at a glance
2. Microorganisms
3. Nutrient
4. Sterilization
5. Liquid and solid state bioreactors
6. Bioreactor operating conditions
7. Bioreactor scale up
8. Cell separation and disruption
9. Product recovery and purification
10. Bioprocess economics.

Contents:
1. Chronic stable angina pectoris: history and epidemiology
2. Stable angina pectoris: definition, clinical presentation and pathophysiologic mechanisms
3. Angina due to obstructive atherosclerotic coronary artery disease: diagnosis and patient risk stratification
4. Microvascular angina: diagnosis, prognosis and treatment
5. Angina in women
6. Management of angina.

Summary: This book assesses the most appropriate forms of aerosol therapy for critically ill patients. Aerosol therapy is applied for the treatment of several pulmonary diseases in addition to some promising applications intended for systemic absorption. Nowadays, aerosol delivery to clinically stable patients in the outpatient settings is done easily with a lot of focus on patient counseling and enhancement of lung deposition. A lot of guidelines are available for several diseases and it could offer adequate guidance to the therapists concerning escalation or de-escalation of therapy to enhance treatment efficiency and safety. However, in critically ill patients aerosol delivery is mostly done by the choice of the respiratory therapist only according to his knowledge. The book describes the type of patients requiring aerosol therapy, different aerosol generators available for the treatment of critically ill patients, mechanisms of aerosol lung deposition, and factors affecting aerosol deposition. It also discusses the special needs of neonates and infants, transitioning aerosol from hospital to home, and the methods of aerosol delivery to different patient e.g. nasal delivery patients, ventilated patients, etc. Moreover, it reviews methods of detecting such aerosol delivery to the lung. At the end, it discusses the suggested monitoring plans and weaning protocols to ensure high efficacy and safety of the ventilatory support in such patients. Given its scope, the book can serve as guidelines or specific recommendations to maximize clinical benefits of medicated aerosols in critically ill patients and it represents a valuable resource for intensivists, pulmonologists and healthcare professionals working at ICUs.

Contents:
The types of patients being treated
What they are being treated for
Where they are being treated
Special needs for neonates, infants and toddler
Aerosol via
Hand held nebulizers
mouthpiece and masks
pMDIs and SMIs - Role of valved holding chambers
DPIs
Hoods
Nasal cannula
NIV
CMV with and without bias flow
Special modes of ventilation - APRV, HFOV, IPV, CHFO, jet ventilation
Drugs for Aerosol in acute and critical care
Transitioning aerosol from hospital to home
Role of training and follow-up
The aerosol generators available for critically ill patient
Mechanisms of aerosol lung deposition
Factors affecting aerosol deposition in critically ill patient
The methods of delivery to different ill patients
Nasal delivery patients, ventilated patients. Methods of detecting aerosol delivery to the lung
Purposed recommendations for aerosol delivery to critically ill patient.

Summary: "Essentials of Aesthetic Surgery may fit in your pocket, but this easy-to-follow guide is teeming with valuable cutting-edge topics in cosmetic surgery. Focusing on both traditional and emerging concepts, techniques and innovations in aesthetic surgery, this portable book draws from the expertise of experienced surgeons to provide step-by-step instructions for the procedures surgeons build their careers on. This comprehensive guide offers readers: A practical guide to the most sought-after procedures, presented by internationally recognized experts Follows the best-selling Essentials of Plastic Surgery structure, which explores techniques and tips for success in a succinct, accessible, bulleted format Modern perspectives on traditional procedures, including facelift, necklift, blepharoplasty, rhinoplasty, breast augmentation, liposuction, abdominoplasty, and thighlift A deeper look at correction of the tear trough deformity, lateral canthopexy, Asian blepharoplasty, secondary and ethnic rhinoplasty, the nasolabial fold, lip augmentation, nonsurgical rejuvenation, augmentation-mastopexy, gluteal augmentation, genital surgery, and transgender surgery Take-home points at the end of each chapter to summarize the content for easy review Rich, high-quality photographs and illustrations for an in-depth understanding of the pertinent anatomy As the role of the plastic surgeon has evolved, so must the techniques and available procedures to address the needs of the diverse aesthetic surgery patient population. Aesthetic surgery continues to grow exponentially in popularity, and this guide provides surgeons with the tools they need to stay abreast of changing trends and innovative techniques to achieve the highest possible patient satisfaction."-- Provided by publisher

Contents:
Cytopathology
Immunohistochemistry for the Surgical Pathologist
Tumors of Unknown Primary
Diagnostic Electron Microscopy
Transplantation Pathology
Microbiology for the Surgical Pathologist
Forensic Pathology
Autopsy
Biomedical Infomatics for Anatomic Pathology
Quality Assurance and Regulations for Anatomic Pathology
Molecular Diagnostic Pathology
Molecular Pathology of Solid Tumors
Human Genetic Disorders
Neuropathology
Lymph Node
Spleen
Bone Marrow
Neoplasms of the Skin and Immunodermatology
Non-Neoplastic Skin Diseases
Endocrine Pathology
Bone and Joints
Soft Tissue Tumors
Tumors of the Salivary Glands
Head and Neck
Eye and Ocular Adnexae
Mediastinum and Thymus
Cardiovascular Pathology
Lung and Pleura
Breast
Vulva and Vagina
Uterus and Fallopian Tube
Ovary and Peritoneum
Placenta and Gestational Trophoblastic Disease
Non-Neoplastic Renal Diseases
Tumors of the Kidney
Urinary Bladder
Renal Pelvis, Ureter, and Urethra
Prostate
Testis and Testicular Adnexa
Penis
Esophagus and Stomach
Small Intestine, Appendix, Colorectum, and Anus
Pancreas
Neoplastic Hepatobiliary Disease
Neoplasms of the Liver and Biliary System. .

Contents:
I: Newborn and infant
The term infant
The preterm infant
Origin of the NICU
Hemodynamics in the infant
Measures of carbon dioxide
Glucose control
Oxygen management: concerns about both hyperoxia and hypoxia in neonates during critical care and intraoperatively
Temperature control
Neonatal resuscitation
Congenital abnormalities and syndromes
Myopathies of the newborn
II: Newborn and infant anesthesia
Preoperative preparation
Developmental pharmacology: the neonate
The newborn airway
Fluid and transfusion management
Neonatal ventilation strategies
Anesthetic-induced neurotoxicity
New anesthetic agents on the horizon
Monitoring of the newborn and young infant under anesthesia
III: Specific newborn and infant procedures
Anesthesia for neurosurgical procedures
Anesthesia for otolaryngologic procedures in infants and neonates
Anesthesia for plastic surgery
Anesthesia for abdominal wall reconstruction procedures
Anesthesia for intra-abdominal procedures
Anesthesia for urologic surgery
Anesthesia for thoracic surgery
Congenital diaphragmatic hernia
Congenital heart disease in the neonate and infant: cardiac catheterization and cardiac surgery
Noncardiac surgery in neonates and infants with cardiac disease
Neonatal and infant tumors
Anesthesia for transplant surgery
Anesthesia for interventional radiology procedures
Anesthesia for conjoined twins
Anesthesia for fetal surgery
IV: Pain management and other newborn and infant anesthesia concerns
Pain management in neonates and infants
Regional anesthesia in neonates and infants
Procedural sedation
Ambulatory anesthesia in infants
Apnea and bradycardia
Neonatal outcomes
Research on newborns and infants

Summary: "This book, which comes in a comprehensive yet compact format, orients undergraduates, students preparing for postgraduate entrance examination, and anesthesia technicians to anesthesia basics, including anatomy, physiology, pharmacology, drugs, types of equipment, and management of specific ailments of all the organ systems. The chapters in this book are simplified by way of tables, flowcharts, and appropriate figures, thereby making the reading and understanding of the subject easy. This book includes chapters on artificial intelligence and updates of the Cardiopulmonary Resuscitation Guidelines 2020 by the American Heart Association (AHA)." -- from preface.

Contents:
Section I: Preliminaries in anesthesia
Section II: General anesthesia
Section III: Regional anesthesia
Section IV: Anesthesia for coexisting diseases
Section V: Subspecialty management
Section VI: Miscellaneous
Section VII: Equipment in anesthesia.

Summary: Essentials of athletic injury management provides the information you need to manage the care of athletic injuries--from prevention, identification and assessment of injuries to interaction with players, parents and physicians. Designed for those beginning careers in coaching, physical education and the fitness profession, this text prepares students to manage injury and emergency situations when an athletic trainer or physician is not available. Action plans, checklists and applications of universal precautions in athletic environments are included to provide the practical tools needed to get started in the field.

Contents:
pt. I. Organizing and establishing an effective athletic health care system. Fitness professional, coaches, and the sports medicine team : defining roles ; Organizing and administering an athletic health care program ; Legal liability and insurance
pt. II. Preventing injuries in an athletic health care system. Preventing injuries through fitness training ; Sports nutrition and supplements ; Selecting and using protective sports equipment ; Understanding the potential dangers of adverse environmental conditions
pt. III. Techniques for treating and managing sport-related injuries ; Bloodborne pathogens, universal precautions, and wound care ; Wrapping and taping techniques ; Understanding the basics of injury rehabilitation ; Helping the injured athlete psychologically
pt. IV. Recognition and management of specific injuries and conditions. Recognizing different sports injuries ; The foot and toes ; The ankle and lower leg ; The knee and related structures ; The thigh, hip, groin, and pelvis ; The shoulder complex ; The elbow, forearm, wrist, and hand ; The spine ; The thorax and abdomen ; The head, face, eyes, ears, nose, and throat ; General medical conditions and additional health concerns ; Substance abuse ; Preventing and managing injuries in young athletes.

Summary: The eleventh edition of Essentials of Athletic Injury Management is written for those students interested in the fitness profession, kinesiology, coaching, or some aspect of sport science or physical education.

Contents:
Part I: Organizing and Establishing an Effective Athletic Health Care System
Chapter 1: Fitness Professionals, Coaches, and the Sports Medicine Team: Defining Roles
Chapter 2: Organizing and Administering an Athletic Health Care Program
Chapter 3: Legal Liability and Insurance
Part II: Preventing Injuries in an Athletic Health Care System
Chapter 4: Preventing Injuries Through Fitness Training
Chapter 5: Sports Nutrition and Supplements
Chapter 6: Selecting and Using Protective Sports Equipment
Chapter 7: Understanding the Potential Dangers of Adverse Environmental Conditions
Part III: Techniques for Treating and Managing Sport-Related Injuries
Chapter 8: Handling Emergency Situations and Injury Assessment
Chapter 9: Bloodborne Pathogens, Universal Precautions, and Wound Care
Chapter 10: Wrapping and Taping Techniques
Chapter 11: Understanding the Basics of Injury Rehabilitation
Chapter 12: Helping the Injured Athlete Psychologically
Part IV: Recognition and Management of Specific Injuries and Conditions
Chapter 13: Recognizing Different Sports Injuries
Chapter 14: The Foot and Toes
Chapter 15: The Ankle and Lower Leg
Chapter 16: The Knee and Related Structures
Chapter 17: The Thigh, Hip, Groin, and Pelvis
Chapter 18: The Shoulder Complex
Chapter 19: The Elbow, Forearm, Wrist, and Hand
Chapter 20: The Spine
Chapter 21: The Thorax and Abdomen
Chapter 22: The Head, Face, Eyes, Ears, Nose, and Throat
Chapter 23: General Medical Conditions and Additional Health Concerns
Chapter 24: Substance Abuse
Chapter 25: Preventing and Managing Injuries in Young Athletes
Glossary
Appendix A: Employment Settings for the Athletic Trainer
Appendix B: Requirements for Certification as an Athletic Trainer
Appendix C: Directional Movements for Body Joints.

Summary: Atrial fibrillation (AF) affects an estimated 1?2% of the population and is the most common cause of sustained cardiac arrhythmia. Critically, the number of patients developing AF is expected to double in the next five decades, leading to increased incidence of stroke, heart failure and other serious thromboembolic events. Essentials of Atrial Fibrillation is a timely investigation of current pharmaceutical trends, clinical guidelines, novel treatments, and ongoing pipeline developments, including ground-breaking advances in the use of novel oral anticoagulants.

Contents:
Epidemiology of atrial fibrillation
Pathogenesis of atrial fibrillation
Classification, diagnosis, and assessment of atrial fibrillation
Rate and rhythm control strategies for atrial fibrillation
Anticoagulant treatment strategies for atrial fibrillation.

Summary: "This textbook attempts to provide a comprehensive overview of audiology at the introductory level; including such topics as acoustics, anatomy and physiology, sound perception, auditory disorders and the nature of hearing impairment, methods of measurement, screening, clinical assessment and clinical management. It is intended to serve as the core text for undergraduate students in speech, language and hearing, and might also serve the needs of beginning-level graduate students who need to learn or review the fundamentals of audiology. It is anticipated that the material will be covered in a one-, two- or three-term undergraduate sequence, depending on the organization of the communication sciences and disorders curriculum at a given college or university"--Provided by publisher

Contents:
Acoustics and sound measurement
Anatomy and physiology of the auditory system
Measurement principles and the nature of hearing
The audiometer and test environment
Pure tone audiometry
Auditory system and related disorders
Acoustic immitance assessment
Speech audiometry
Clinical masking
Behavioral tests for audiological diagnosis
Physiological methods in audiology
Assessment of infants and children
Audiological screening
Nonorganic hearing loss
Audiological management 1
Audiological management 2
Effects of noise and hearing conservation
Appendix A : Combining OBLs into db SPL and dbA
Appendix B : Alphabetical listing of spondaic words commonly used in clinical practice
Appendix C : CID Auditory Test W-22 : word lists 1-4
Appendix D : Northwestern University Auditory Test No. 6
Appendix E : Spanish bisyllabic words for speech recognition testing
Appendix F : Boothroyd isophonemic word lists
Appendix G : An example of the AzBio sentence lists
Appendix H : Lists 1 and 2 of the Basic English Lexicon (BEL) sentences
Appendix I : Lexical Neighborhood Test (LNT)
Appendix J : Multisyllabic Lexical Neighborhood Test (MLNT)
Appendix K : PBK-50 (PB Kindergarten) words lists
Appendix L : Word Intelligibility by Picture (WIPI) Test word lists
Appendix M : Northwestern University Children's Perception of Speech (NU-CHIPS) Test word lists
Appendix N : Selected resources for auditory-visual training.

Summary: Introductory audiology is an essential and fundamental aspect of the education of all students who are interested in the two related professions of speech-language pathology and audiology. This book is primarily intended to serve as a comprehensive introductory text for students who are preparing to enter both of these fields. As such, it tries to address the needs of at least two rather different groups of students. Those planning a career in audiology need a broad overview of the field and a firm understanding of its many basic principles so that they have a solid foundation for the future as doctors of audiology in clinical practice.

Contents:
Acoustics and Sound Measurement
Anatomy and Physiology of the Auditory System
Measurement Principles and the Nature of Hearing
The Audiometer and Test Environment
Pure Tone Audiometry
Auditory System and Related Disorders
Acoustic Immittance Assessment
Speech Audiometry
Clinical Masking
Behavioral Tests for Audiological Diagnosis
Physiological Methods in Audiology
Assessment of Infants and Children
Audiological Screening
Nonorganic Hearing Loss
Audiological Management I
Audiological Management II
Effects of Noise and Hearing Conservation.

Contents:
v. 1. No individual title
v. 2. Recent advances, topics, and developments
v. 3. Current methods and modern trends.

Summary: This book covers new and exciting topics which have emerged in the area of autopsy recently, including the three different post-mortem CT-angiography systems currently available to practitioners in this field; a highly topical chapter on the role of genetic abnormalities in the handling of drugs within the body and how this can affect the interpretation of toxicological results in relation to how the drug may have caused or contributed to death; an update on the current classification and considerations related to deaths due to hanging; a review of injuries and fatalities caused by animals including post-mortem scavenging; an authoritative review of poisons and toxins from water and the life that inhabits it; and recent advances in knowledge in the use of entomology as an investigative tool as well as knowledge related to colonisation of cadavers by insects, animals and birds. Essentials of Autopsy Practice: Advances, Updates and Emerging Technologies is a multi-subject book, aimed at different grades of practitioners, from different practice areas, covering topics that are currently discussed and anticipated to be discussed in the field of autopsy practice over the next few years.

Contents:
Post-Mortem Computed Tomography (PMCT) Scanning with Angiography (PMCTA). A Description of Three Distinct Methods
Death by Hanging
Marine Toxins
The Dismembered Body
Medico-legal Autopsies and Pharmacogenetics
Forensic Entomology: a Synopsis, Guide and Update
Advances in the Use of Latent Finger Marks.

Summary: This book covers topical subjects within the field of death investigation, where changes in practice have recently occurred. The topics embrace the multi-disciplinary approach required for death investigation, and address advances in the field of forensic photography, pathology, and 3D printing as applied to forensics. This volume includes chapters on high altitude deaths, the role of 3D-printing applied to forensic investigations, photogrammetry, commotion cordis (an uncommon cause of fatal cardiac arrest) and the cricoid cartilage. Essentials of Autopsy Practice: Reviews, Updates and Advances is an educational and practical resource aimed at trainees and consultants, generalists and specialists, and multi-disciplinary teams. -- Provided by publisher.

Contents:
1. The application of photogrammetry for forensic 3D recording of crime scenes, evidence and people / Chiara Villa and Christina Jacobsen
2. 3D printing applied to forensic investigations / Mike Biggs
3. Post-mortem examination of infant bridging veins and subdural haemorrhage / Emma C. Cheshire and Neil C. Harris
4. Traumatic carotid sinus reflex and postmortem investigation of the glomus caroticum in cases of pressure to the neck / Elke Doberentz and Burkhard Madea
5. The cricoid cartilage / Guy N. Rutty
6. Mountain deaths / Jeremy Windsor
7. Fatalities related to extreme aerial sports / Francesco Feletti
8. Commotio cordis / Ritesh G. Menezes, Mohammed Madadin, and Muhammad Shariq Usman.

Summary: This book covers topical subjects within the field of death investigation, where changes in practice have recently occurred. The topics embrace the multi-disciplinary approach required for death investigation, and address advances in the fields of forensic fractography in relation to road traffic death investigations, pathology, MicroCt and 3D printing as applied to forensics. Chapters are written in a uniform easy-to-follow format to ensure they are accessible to both specialists and non-specialists in the field. Essentials of Autopsy Practice Updates and Reviews to Aid Practice is a practical resource covering the latest advances in autopsy practice, making it an ideal resource for trainees, consultants, generalists and specialists, along with multi-disciplinary teams working in this field.

Contents:
Forensic application of "Free-D" software
Post-mortem cardiac magnetic resonance imaging
The use of micro-computed tomography for forensic applications
The role of fractography in forensic pathology and forensic anthropology examinations
The application of radiographic imaging in forensic odontology
Disaster victim identification: Traditional approaches and changing practices
Examining an already autopsied or exhumed body
Death associated with trees
Mountain death revisited: Mass slope movements, mountain associated suspension and volcanos.

Summary: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it mostly focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Unlike other bioinformatics books which are mostly theoretical, this book provides practical examples for the readers on state-of-the-art open source tools to solve biological problems. Flow charts of experiments, graphical illustrations, and mock data are included for quick reference. Volume I is therefore an ideal companion for students and early stage professionals wishing to master this blooming field.

Contents:
Intro; Foreword; Preface; Contents; About the Editors;
Chapter 1: Introduction to Bioinformatics; 1.1 Introduction; 1.2 The Role of Bioinformatics in Gene Expression Data Analysis; 1.3 The Role of Bioinformatics in Gene/Genome Mapping; 1.4 Role of Bioinformatics in Sequence Alignment and Similarity Search; 1.5 Contribution of Bioinformatics toward Modern Cancer Research; 1.6 The Domain of Structural Bioinformatics; 1.7 Bioinformatics Processing of Big Data; 1.8 Conclusion; References;
Chapter 2: Introduction to Biological Databases; 2.1 Introduction to Databases; 2.2 Types of Databases 2.2.1 Relational Databases2.2.2 Object-Oriented Database; 2.3 Introduction to Biological Databases; 2.3.1 Classification of Biological Databases; 2.3.2 Primary Database; 2.3.3 Secondary Databases; 2.3.4 Specialized Databases; 2.3.5 Interconnection between Biological Databases; 2.4 Retrieval from Databases; 2.5 Conclusion; References;
Chapter 3: Sequence Databases; 3.1 Introduction; 3.2 Sequence Data Generation; 3.2.1 The First Generation of Sequencing; 3.2.2 The Second Generation of Sequencing; 3.2.3 The Third Generation of Sequencing; 3.3 Classes of Biological Databases 3.4 Types of Sequence Databases3.4.1 Nucleotide Sequence Databases; 3.4.1.1 EMBL/DDBJ/GenBank; 3.4.1.2 RefSeq; 3.4.1.3 Ensembl; 3.4.2 Protein Sequence Database; 3.4.2.1 TrEMBL; 3.4.2.2 GenPept; 3.4.2.3 Entrez Protein; 3.4.2.4 UniProt; 3.5 Sequence Submission; 3.5.1 Sequin; 3.5.2 BankIt; 3.5.3 Webin; 3.6 Retrieval; 3.6.1 SRS (Sequence Retrieval System); 3.6.2 Entrez; 3.6.3 DBGET; 3.7 Conclusion; References;
Chapter 4: Biological 3D Structural Databases; 4.1 Introduction; 4.1.1 X-Ray Crystallography; 4.1.2 Crystal Formation; 4.1.3 Structure Determination; 4.2 Macromolecular Structural Databases 4.2.1 Protein Data Bank wwPDB4.2.1.1 RCSB PDB; 4.3 PDBsum: Structural Summaries of PDB Entries; 4.4 sc-PDB: A 3D Database of Ligandable Binding Sites; 4.5 PDBTM: Protein Data Bank of Transmembrane Proteins; 4.6 CATH Database; 4.7 SCOP (Structural Classification of Proteins) Database; 4.8 Structure Comparison Servers; 4.9 Conclusion; References;
Chapter 5: Other Biological Databases; 5.1 Introduction; 5.2 Gene or Genome Annotation Databases; 5.2.1 GO/GOA Databases; 5.2.2 UCSC Genome Browser: Annotation Database; 5.3 Protein Annotation Databases; 5.3.1 PRIDE Archive; 5.3.2 SWISS-2DPAGE 5.3.3 Domain Databases5.4 Network Databases; 5.4.1 IntAct; 5.5 Pathway Databases; 5.5.1 Kyoto Encyclopedia of Genes and Genomes; 5.5.2 BioCyc; 5.5.3 Ingenuity Pathways Knowledge Base; 5.5.4 Reactome Pathway Databases; 5.5.5 Other Pathway Databases; 5.6 Drug Databases; 5.6.1 DrugBank; 5.6.2 PharmGKB; 5.6.3 ChEBI; 5.6.4 PubChem; 5.6.5 ZINC Database; 5.7 Specialized Database; 5.7.1 Model Organism Databases; 5.7.2 IntEnz; 5.7.3 EPD; 5.7.4 TRANSFAC; 5.8 Scientific Literature Database; 5.8.1 PubMed; 5.8.2 SCI (Science Citation Index); 5.8.3 Google Scholar; 5.9 Conclusion; References

Summary: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.

Contents:
1. Bioinformatics strategies for molecular diagnostics o Candidate gene selection and analysis of Rare diseaseso Candidate gene selection and analysis of Complex diseases2. Bioinformatics tools for Molecular Diagnosticso Single Gene Disorders
Case studieso Polygenic Disorders
Case studieso Genetic Tests
Tools, Results, Interpretation3. Bioinformatics approaches for Genetic Risk Marker Studieso Population Geneticso Gene Polymorphismso Gene Expression Assayso Genetic Statistics4. Bioinformatics for Disease Prognosticso Pharmacogeneticso Efficacyo Toxicityo Adverse reactions o Biomarker Selection and Monitoringo Precision Medicine5. Bioinformatics tools in Gene Therapyo Enzyme Replacement- Bioinformatics role is limitedo Gene Replacement (Knock-in)o Gene Silencing(RNAi)o Gene Editing (CRISPR)6. Bioinformatics tools in Disease Therapeutics
Data analysis tools and application o Drug Discovery o Protein-Drug Interactionso Drug-Body metabolism studieso Microbiome.