Books

Summary: This encyclopedic reference book on the treatment of intracranial aneurysms offers a case-based approach to the subject that has the benefit of fully reflecting the highly individual technical and clinical challenges encountered in aneurysm patients. The book is structured by aneurysm location, ensuring ease of use. Readers will find solutions for most clinical situations that they may encounter. Different treatment strategies are described, highlighting their respective pros and cons in particular circumstances. The coverage encompasses both basic techniques, such as coil occlusion and parent vessel occlusion, and the latest developments, including extra- and intrasaccular flow diversion, intrasaccular flow disruption, bifurcation stenting, and hybrid procedures combining microsurgical and endovascular elements. Potential procedural complications are identified, and bail-out strategies to anticipate, avoid, and solve major issues are described. The authors are all respected experts in the field, and the book will be of value to vascular and endovascular neurosurgeons, interventional neuroradiologists and neurologists, stroke neurologists, and other practitioners at all levels of experience.

Contents:
Intro
Preface
Acknowledgments
Contents
About the Editors
Contributors
Part I: Cervical Internal Carotid Artery
1 Cervical Internal Carotid Artery Aneurysm: Spontaneous Dissection of the Cervical Internal Carotid Artery Resulting in Elong...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Follow-Up Examinations
Treatment Strategy
Treatment
Follow-Up Examinations
Clinical Outcome
Discussion
Therapeutic Alternatives
References
Part II: Petrous Internal Carotid Artery 2 Petrous Internal Carotid Artery Aneurysm: A Giant Fusiform Aneurysm, Flow Diversion, Several Treatment Sessions, Metamizole ...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome
Follow-Up and Subsequent Treatments
Clinical Outcome
Discussion
Therapeutic Alternatives
References
3 Petrous Internal Carotid Artery Aneurysm: Endovascular Treatment with Coils and Flow Diverter Stents of a Large Petrous Inte...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome
Follow-Up Examination
Treatment Strategy Treatment
Clinical Outcome
Follow-Up Examinations
Treatment Strategy
Treatment
Follow-Up Examinations
Treatment Strategy
Treatment
Follow-Up Examination
Treatment Strategy
Treatment
Follow-Up Examinations
Clinical Outcome
Discussion
Therapeutic Alternatives
References
Part III: Cavernous Internal Carotid Artery
4 Cavernous Internal Carotid Artery Aneurysm: Visual Disturbance Due to a Large Cavernous Aneurysm Presumably Causing Recurren...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome Follow-Up Examinations
Discussion
Therapeutic Alternatives
References
5 Cavernous Internal Carotid Artery Aneurysm: Diplopia due to a Large Cavernous Aneurysm Causing Oculomotor Nerve Palsy
Parti...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome
Follow-Up Examinations
Discussion
Therapeutic Alternatives
References
6 Cavernous Internal Carotid Artery Aneurysm: Rupture of a Presumably Traumatic Cavernous Internal Carotid Artery Pseudoaneury...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment Clinical Outcome
Discussion
Therapeutic Alternatives
References
7 Cavernous Internal Carotid Artery Aneurysm: Exsanguinating Iatrogenic Internal Carotid Artery Injury During Transsphenoidal ...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome
Follow-Up Examinations
Discussion
Therapeutic Alternatives
References
8 Cavernous Internal Carotid Artery Aneurysm: Large Cavernous Carotid Artery Aneurysm Causing Compression of the Internal Caro...
Patient
Diagnostic Imaging
Treatment Strategy
Treatment
Clinical Outcome

Summary: Popliteal aneurysms are still controversial in terms of their pathogenesis, and challenging in terms of their treatment. This book offers a detailed overview of the latest advances in our understanding of the disease, and highlights the latest theories. Divided into eght sections, it focuses on: the historical background, embryology and anatomy of the popliteal artery, clinical presentation and diagnosis, pros and cons of traditional surgical techniques, pros and cons of advanced endovascuar techniques. The last section focuses on non-atherosclerotic popliteal aneurysme, i.e. on diseases in which popliteal aneurysms may specifically appear, rendering more challenging the diagnosis and the treatment As stressed in the foreword by the Chief Editor of the Journal of Vascuar Surgery, this book, given its scope, offers a valuable guide for all health professionals - experts and in training -.involved in vascular pathology and surgery.

Contents:
Part-1: History. A surgeon's journey through history up to the end of the XIX century
Modern historical background
Part-2: The Popliteal Artery: Embryology and Anatomy. The popliteal artery: embryology
The popliteal artery: reminding normal and variant anatomy
Persistence of the ischiadic artery
Popliteal artery entrapment
Part-3: Popliteal Aneurysms: Pathology. Surgical pathology
Part-4: Atherosclerotic Popliteal Aneurysms: Clinical Aspects. Definition, prevalence, etiopathogenesis
The "problem" of arteriomegaly
Outline of patients with atherosclerotic popliteal aneurysm
Clinical presentation. Part-5: Popliteal Aneurysms: Diagnosis. Diagnostic procedures. Part-6: Atherosclerotic Popliteal Aneurysms: Surgical Treatment. (with an appendix on sex and popliteal aneurysms). Operative indication, surgical approach and tactics
Primary amputation. Endoaneurysmorrhaphy. Lumbar sympathectomy. The use of tourniquet
Treatment with reestablishment of circulation
Late sequelae of surgical treatment. Part-7: Atherosclerotic Popliteal Aneurysms: Endovascular Treatment. An up-to-date of popliteal artery anatomy, static and dynamic
Home-made and early stent grafts
The Hemobahn-Viabahn stent grafts
Other stent grafts and hybrid procedures
The current role of endografting
Part-8: Non-Atherosclerotic Popliteal Aneurysms.. Behçet's disease
Kawasaki's disease
Neurofibromatosis
Fibromuscular dysplasia
Disorders of the connective tissue
Klippel-Trénaunay syndrome, Parkes Weber syndrome
HIV/AIDS
Mycotic aneurysms
Miscellaneous.

Contents:
History of research on angiogenesis
Immune cells as a source and target of angiogenic and lymphangiogenic factors
Neuropilins: role in signalling, angiogenesis and disease
Class 3 semaphorin in angiogenesis and lymphangiogenesis
Angiogenic and antiangiogenic chemokines
Role of uPA/uPAR in the modulation of angiogenesis
Neutrophil-derived cytokines involved in physiological and pathological angiogenesis
Roles of eosinophils in the modulation of angiogenesis
Regulatory T cells, leptin and angiogenesis
Angiogenesis as a therapeutic target for obesity and metabolic diseases
Angiogenesis in multiple myeloma
Angiogenesis inhibitors in the treatment of prostate cancer
Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease.

Contents:
Angiogenesis: General Concepts
Infantile Hemangioma: New Insights on Pathogenesis and Beta Blockers Mechanisms of Action
The Role of Angiogenesis in the Development of Psoriasis
Angiogenesis and Nonmelanoma Skin Cancer
Melanoma
Potential Role of Angiogenesis and Lymphangiogenesis in Atopic Dermatitis: Evidence from Human Studies and Lessons from an Animal Model of Human Disease
Chemoprevention and Angiogenesis
Angiogenesis and Pathogenesis of Port Wine Stain and Infantile Hemangiomas.

Contents:
The anatomic renaissance
The angiosome concept
Clinical applications
The angiosomes of the head and neck
The angiosomes of the torso
The angiosomes of the upper limb
The angiosomes of the lower limb.

Summary: This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015). Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.

Contents:
INTRODUCTION
1.ANGIOTENSIN-(1-7) FORMATION AND METABOLISM
Part I. TOOLS FOR STUDYING ANG-(1-7)
2. Pharmacological Tools-RAS
3. Genetic Models (ACE2 Models, MAS Models, Ang-(1-7) Models)
Part II. ACTIONS OF ANGIOTENSIN-(1-7)
4. Brain (Ang-(1-7) Metabolism in the Brain, Ang-(1-7) Location in the Brain, MAS Location in the Brain, Ang-(1-7) Actions in the Brain, Cardiovascular Effects of Angiotensin-(1-7) at Specific Medullary Sites, Cardiovascular Effects of Angiotensin-(1-7) at Specific Hypothalamic Sites, Other Angiotensin-(1-7) Effects in the Brain, Neurotransmitter / Neuromodulator Effects of Ang-(1-7)
5. Heart (B1 Coronary vessels & Cardiomyocytes)
6. Ang-(1-7) and Cardioprotection
7. Blood Vessels
8. Kidney
9. Lung
10. Endocrine System
11. Skeletal Muscle System
12. Liver
13. Angiotensin-(1-7) and inflammation
14. J. Angiotensin-(-1-7) and Cancer
15. CONCLUDING REMARKS
ACKNOWLEDGMENTS.

Contents:
v. 1. Molecular biology, biochemistry, pharmacology, and clinical perspectives
v. 2. Medi cinal chemistry.

Contents:
Conceptual Issues
The Different Facets of Anhedonia and Their Associations with Different Psychopathologies
Understanding Anhedonia: The Role of Perceived Control
Circadian Fluctuation of Reward Response and Synchronization to Reward
Anhedonia in Children and Adolescents
Musical Anhedonia and Visual Hypoemotionality: Selective Loss of Emotional Experience in Music and Vision
Projecting Oneself into the Future, an Intervention for Improving Pleasure in Patients with Anhedonia
Neurobiological Advances
Translational Models of Dopaminergic Mechanisms for Motivational Deficits in Anhedonic Patients
Brain Systems for the Pleasure of Food and Other Primary Rewards
Neurogenetics and Neurobiology of Dopamine in Anhedonia
The Neuroendocrinology of Anhedonia
Electrophysiological Signatures of Reward Processing in Anhedonia
Anhedonia in Mouse Models of Methamphetamine-Induced Drug Seeking Behavior
Neural Basis of Anhedonia Associated with Stress-Induced Eating Disorders
Brain Imaging Correlates of Anhedonia.

Contents:
Anhedonia in Psychotic Disorders
Anhedonia in Schizophrenia: A Brief History and Overview of the Construct
Measuring Anhedonia in Schizophrenia-Spectrum Disorders: A Selective Update
Hedonic Capacity and Related Factors in Schizophrenia and Schizoaffective Disorder
Anhedonia as an Indicator of Genetic Vulnerability to Schizophrenia
Anhedonia in Schizophrenia: A Deficit in Translating Reward Information into Motivated Behavior
Anhedonia in Mood and Personality Disorders
Neural Correlates of Anhedonia as a Trait Marker for Depression
Anhedonia in Trauma Related Disorders: The Good, the Bad, and the Shut-Down
Anhedonia and Anorexia Nervosa: A Neurocognitive Perspective
Anhedonia and Negative Symptom Schizotypy
Anticipatory and Consummatory Anhedonia in Individuals with Schizotypal Traits
Anhedonia and Risk of Suicide: An Overview
Anhedonia in Neurological and Physical Disorders
Anhedonia and Epilepsy
Anhedonia in Parkinson's Disease and Other Movement Disorders
Anhedonia in Heart Disease
Cerebrovascular Diseases: Post-stroke Depression and Anhedonia.

Contents:

v. 1. Biochemistry.

Summary: Among the offspring of humans and other animals are occasional individuals that are malformed in whole or in part. The most grossly abnormal of these have been referred to from ancient times as monsters, because their birth was thought to foretell doom; the less severely affected are usually known as anomalies. This volume digs deeply into the cellular and molecular processes of embryonic development that go awry in such exceptional situations. It focuses on the physical mechanisms of how genes instruct cells to build anatomy, as well as the underlying forces of evolution that shaped these mechanisms over eons of geologic time. The narrative is framed in a historical perspective that should help students trying to make sense of these complex subjects. Each chapter is written in the style of a Sherlock Holmes story, starting with the clues and ending with a solution to the mystery.

Summary: Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field. Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases. Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering.

Summary: This two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology. This first volume mainly focuses on artificial insemination, embryo transfer technologies in diverse animal species and cryopreservation of oocytes and embryos.

Contents:
1. Evolution of Animal Breeding and Animal Biotechnology
2. Future Agricultural Animals: The Need for Biotechnology
3. Artificial Insemination in Domestic and Wild Animal Species
4. Technique and Application of Sex Sorted Sperm in Domestic Farm Animals
5. ET-Technologies in Domestic Cattle
6. ET-Technology in Small Ruminants
7. ET-Technology in Domestic Pigs
8. ET-Technologies in Horses
9. Endoscopy in Cattle Reproduction
10. Transvaginal Ultrasound-Guided Oocyte Retrieval (OPU: Ovum Pick-Up) in Cows and Mares
11. Preservation of Gametes and Embryos
12. In vitro Production of Farm Animal Embryos.

Summary: This two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology. This second volume is dedicated to genetic tools in animal biotechnology such as somatic cloning, transgenic technologies and the application of stem cells in livestock breeding. Also, ethics and legal aspects are discussed.

Contents:
1. Somatic Cloning of Livestock by Somatic Cell Nuclear Transfer
2. Commercial Applications of SCNT in Livestock
3. Epigenetic Features of Animal Biotechnologies
4. Current Status of Genomic Maps, Genomic Selection/GBV in Livestock
5. Embryo Biopsies for Genomic Selection
6. Production of Transgenic Livestock: Overview of Transgenic Technologies
7. DNA-Nucleases and Their Use in Livestock Production
8. Regulatory Dysfunction Inhibits the Development and Application of Transgenic Livestock for use in Agriculture
9. Genetically Engineered Large Animals in Biomedicine
10. Stem Cells and Cell Conversion in Livestock
11. The Legal Governance of Animal Biotechnologies
12. Ethical Aspects of Animal Biotechnology
13. Public Perception of Animal Biotechnology.

Summary: Animal cells are the preferred "cell factories" for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a℗ℓrecommended volume for all biotechnology libraries.

Summary: This volume investigates the contemporary fauna that inhabit the Cuatro Ciénegas Basin. Divided into 15 chapters, it addresses and describes their diversity, taxonomic and biogeogaphic affinities, and ecological characteristics. The Cuatro Ciénegas Valley is a unique oasis in the south-central region of the State of Coahuila, part of the Sonoran Desert, in Mexico. Several clues, specially derived from the study of the microbiota, suggest a very ancient origin of the valley and its permanence through time. This condition had promoted a high level of endemism and led to unique interactions between the resident species.

Contents:
The fauna of the Cuatro Ciénegas Basin, a unique assemblage of species, habitats and evolutionary histories
Helminth community structure of some freshwater fishes of the Cuatro Ciénegas Basin: patterns and processes
Abundance and diversity of the soil microarthropod fauna from the Cuatro Ciénegas Basin
Scorpion (Arachnida: Scorpiones) from the Cuatro Ciénegas Basin
The spiders of the Churince region, Cuatro Ciénegas Basin: A comparison with other desert areas of North America
Crustaceans from the Cuatro Ciénegas Basin: diversity, origin and endemism
Spatial and temporal patterns of diversity of the Lepidopter (Papilionoidea sensu lato) in the Cuatro Ciénegas Basin
Diversity and resource use patterns of bees and flies that visit flowers in the Cuatro Ciénegas Basin
Odonata of the Cuatro Ciénegas Basin
Diversity and community structure of ants in the Cuatro Ciénegas Basin, Coahuila, Mexico
Prostigmatid mites (Arachnida: Acariformes: Prostigmata) parasitic on amphibians and reptiles in the Cuatro Ciénegas Basin
Systematics of the fish from the Cuatro Ciénegas Basin
Diversity of amphibians and reptiles in the Cuatro Ciénegas Basin
The birds of the Cuatro Ciénegas Basin, a wetland within the Chihuahuan Desert
Evaluating the hypothesis of Plesitocene refugia for mammals in the Cuatro Ciénegas Basin
Index.

Contents:
Targeted small noncoding rna-directed gene activation in human cells
Isolation of chromatoid bodies from mouse testis as a rich source of short RNAs
Generation of endo-siRNAs in xenopus laevis oocytes
Analysis of endo-siRNAs in drosophila
Methods for studying the biological consequences of endo-siRNA deficiency in drosophila melanogaster
Small RNA library cloning procedure for deep sequencing of specific endogenous siRNA classes in caenorhabditis elegans
Assays for direct and indirect effects of c. Elegans endo-siRNAs
Extraction and nonradioactive detection of small RNA molecules
P19-mediated enrichment and detection of siRNAs
Detection of small noncoding RNAs by in situ hybridization using probes of 2'-o-methyl RNA + LNA
Enhanced detection of small RNAs using a nonradioactive approach
Computing siRNA and piRNA overlap signatures
Isolation of small interfering RNAs using viral suppressors of RNA interference
Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments
Differential DNA methylation patterns in endo-siRNAs mediated silencing of LINE-1 retrotransposons.

Contents:
Influenza A virus / David L. Suarez
Diagnostics and surveillance methods / Erica Spackman, David L. Suarez and Giovanni Cattoli
The economics of animal influenza / Anni McLeod and Jan Hinrichs
Trade and food safety aspects for animal influenza viruses / David E. Swayne
Public health implications of animal influenza viruses / Nancy Cox, Sue Trock and Tim Uyeki
The innate and adaptive immune response to avian influenza virus / Lonneke Vervelde and Darrell R. Kapczynski
Wild bird infections and the ecology of avian influenza viruses / David Stallknecht and Justin Brown
The global nature of avian influenza / David E. Swayne
Multi-continental panzootic of H5 highly pathogenic avian influenza (1996-2015) / Les Sims and Ian Brown
High pathogenicity avian influenza outbreaks since 2008 except multi-continental panzootic of H5 goose/guangdong-lineage viruses / Ian Brown, Celia Abolnik, Juan Garcia-Garcia, Sam McCullough, David E. Swayne and Giovanni Cattoli
Low pathogenicity avian influenza / Daniel Perez and J.J. (Sjaak) deWit
Epidemiology of avian influenza in agricultural and other man-made systems / Les Sims, John Weaver and David E. Swayne
Pathobiology of avian influenza in domestic ducks / Mary Pantin-Jackwood
Avian influenza control strategies / Les Sims and David E. Swayne
Vaccines and vaccination for avian influenza in poultry / David E. Swayne and Darrell R. Kapczynski
The disease, pathobiology and epidemiology of influenza infections in pigs / Susan E. Detmer
Immunity, diagnosis and intervention strategies of influenza infections in pigs / Montserrat Torremorell
Global evolution of influenza A viruses in swine / Amy Vincent, Nicola Lewis and Richard Webby
Vaccines and vaccination for swine influenza : differing situations in Europe and the USA / Kristine van Reeth, Amy L. Vincent and Kelly Lager
The disease, pathobiology and epidemiology of influenza infections in horses / Gabrielle A, Landolt and Thomas M. Chambers
Vaccines and vaccination to control equine influenza / Thomas M. Chambers
Canine influenza / Colin R. Parrish and Edward J. Dubovi
Sporadic influenza A virus infections of miscellaneous mammal species / Edwin J.B. Veldhuis Kroeze and Thijs Kuiken
Mammalian experimental models and implications in understanding zoonotic potential / Jessica A. Belser and Terrence M. Tumpey.

Contents:
Anatomy of the reproductive system / Gheorghe M. Constantinescu
Anatomy of mammalian (endocrine) glands controlling the reproduction / Gheorghe M. Constantinescu
Models for investigating placental biology / Laramie Pence and Bhanu P. Telugu
Early developmental programming of the ovarian reserve, ovarian function and fertility / F. Mossa, S.W. Walsh, A.C.O. Evans, J.J. Ireland
Small non-coding RNAs in gametogenesis / Lukasz Smorag and D.V. Krishna Pantakani
The ovarian follicle of cows as a model for human / Marc-Andre Sirard
Production of energy and determination of competence : past knowledge, present research and future opportunities in oocyte and embryo metabolism / Jason R. Herrick, Elena Silva, Rebecca L. Krisher
Signal transduction pathways in oocyte maturation / Francois J Richard, Nicolas Santiquet, Annick Bergeron and Daulat Raheem Khan
Pig models of reproduction / B.R. Mordhorst and R.S. Prather
The mare as an animal model for reproductive aging in the woman / Elaine M. Carnevale
Spotlight on reproduction in domestic dogs / Shirley J Wright
Animal models of inflammation during pregnancy / Karen E. Racicot and Keith E. Latham
Practical approaches, achievements, and perspectives in the study on signal transduction in oocyte maturation and fertilization : focusing on the African clawed frog xenopus laevis as an animal model / Ken-ichi Sato
Prezygotic chromosomal examination of mouse spermatozoa / Hiroyuki Watanabe and Hiroyuki Tateno
Molecular and cellular aspects of mammalian sperm acrosomal exocytosis / Florenza A. La Spina, Cintia Stival, Dario Krapf, Mariano G. Buffone
Sperm chromatin dynamics associated with male fertility in mammals / Naseer A. Kutchy, Sule Dogan, Abdullah Kaya, Arlindo Moura, Erdogan Memili
Epigenome modification and ubiquitin-dependent proteolysis during pronuclear development of the mammalian zygote (animal models to study pronuclear development) / Jan Nevoral and Peter Sutovsky
Alterations of epignome induced by environment in reproduction / Zhao-Jia Ge, Shen Yin, Heide Schatten
Towards development of pluripotent porcine stem cells by road-mapping early embryonic development / Stoyan Petkov, Kristine Freude, Kaveh Mashayekhi, Poul Hyttel and Vanessa Hall
Applications of metabolomics in reproductive biology / Ana Luiza Cazaux Velho, Rodrigo Oliveira, Arlindo Moura, Abdullah Kaya, Erdogan Memili
Cryopreservation of mammalian oocytes / Muhammad Anzar.

Contents:
Chapter 1. Introduction
Chapter 2. Ethical aspects of the use of animals in translational research
Chapter 3. Study design
Chapter 4. Improving external validity of experimental animal data
Chapter 5. How to end selective reporting in animal research
Chapter 6. A comprehensive overview of mouse models in oncology
Chapter 7. Mouse models of advanced spontaneous metastasis for experiemental therapeutics
Chapter 8. Spontaneous animal tumor models
Chapter 9. Dog models of naturally occurring cancer
Chapter 10. Improving preclincal cancer models: lessons from human and canine clinical trials of metronomic chemotherapy .

Summary: This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects.

Contents:
Intro
Preface
Contents
1: A History of Mouse Genetics: From Fancy Mice to Mutations in Every Gene
1.1 Overview
1.2 Establishing the Mouse as a Mammalian Model for Research
1.2.1 Mendelian Genetics in Mice
1.2.2 Inbred Mouse Strains
1.3 Getting to Know the Mouse Genome: From Inbred Lines to Genetic Maps
1.3.1 Inbred and Congenic Strains
1.3.2 The Origins of Developmental Genetics
1.3.3 Linkage Analysis, Complementation Tests, and Recombination Maps
1.3.4 Cytogenetics: Chromosomal Maps and Rearrangements 1.3.5 Improving Linkage Maps: New Markers, Recombinant Inbred Lines, and Interspecific Backcrosses
1.3.6 From Linkage Maps to Physical Maps
1.4 The Molecular Biology Revolution and Mouse Genetics
1.5 Manipulating the Mouse Genome: Making Mutants
1.5.1 The Power of Mutagens
1.5.2 Transgenesis: Introducing Exogenous DNA in the Mouse Genome
1.5.3 Targeted Mutagenesis Through Homologous Recombination
1.5.4 Genome Engineering with Endonucleases: CRISPR/Cas9 Engineering
1.6 The Mouse Genome Sequence 1.7 A Mutant in Every Gene: Large-Scale Approaches to Study Gene Function
1.7.1 Forward Mutagenesis Screens and Positional Cloning
1.7.2 Gene-Trap Mutagenesis Screens
1.7.3 The International Knockout and Phenotyping Consortia
1.8 Future Perspectives
References
2: Mouse Models of Neural Tube Defects
2.1 Overview
2.2 Types of NTDs
2.3 Diagnosis and Treatment of NTDs
2.4 The Etiology of NTDs
2.5 NTDs Result from Failure of Neural Tube Closure
2.6 Mouse Models Have Been Instrumental in Elucidating the Mechanics of Neural Tube Closure 2.7 Convergent Extension Movements and the Planar Cell Polarity Pathway
2.8 Hinge Point Formation
2.9 Apical Constriction Is Coordinated with PCP Activation in the Neural Plate
2.10 Formation of Hinge Points Is Regulated by Shh and BMPs
2.11 PCP, Ciliogenesis, and Shh Signaling
2.12 Role of the Nonneural Ectoderm in Neural Fold Elevation and Fusion
2.13 Prevention of NTDs by Micronutrient Supplementation
2.14 Mechanisms by Which Folic Acid Prevents NTDs
2.15 Folate is a Cofactor Required for Synthesis of DNA, Amino Acid and Methyl Donors 2.16 Folate and Homocysteine
2.17 Studies in Mice Suggest Supplementation with Inositol or Formate May Prevent Folate-Resistant NTDs
2.18 Future Directions
References
3: Animal Models of Pancreas Development, Developmental Disorders, and Disease
3.1 Overview
3.2 Introduction
3.2.1 Overview of Pancreas Development
3.2.2 Molecular Regulation of Pancreas Development
3.2.3 Developmental Defects and Their Impact on Pancreatic Function and Disease
3.3 Juvenile and Adult Diseases of the Pancreas
3.3.1 Type 1 Diabetes Mellitus (T1DM) 3.3.2 Type 2 Diabetes Mellitus (T2DM)

Contents:
1. Unilateral common carotid artery ligation as a model of perinatal asphyxia: the original Rice-Vannucci model
2. Bilateral uterine artery ligation (BUAL): placental insufficiency causing fetal growth restriction and cerebral palsy
3. Perinatal intracerebral hemorrhage model and developmental disability
4. Preterm rabbit model of glycerol-induced intraventricular hemorrhage
5. Models of perinatal brain injury in premature and term newborns resulting from gestational inflammation due to inactivated group B streptococcus (GBS), or lipopolysaccharide (LPS) from E. coli and/or immediately postnatal hypoxia-ischemia (HI)
6. Fetal brain activity in the sheep model with intrauterine hypoxia
7. Studies of perinatal asphyxial brain injury in the fetal sheep
8, The sheep as a model of brain injury in the premature infant
9. The rabbit as a model of cerebral palsy
10. A newborn piglet survival model of post-hemorrhagic ventricular dilatation (PHVD)
11. Physiologic aspects of the piglet as a model of neonatal hypoxia and reoxygenation
12. The newborn pig global hypoxic-ischemic model of preinatal brain and organ injury
13. Animal models of fetal alcohol spectrum disorder
14. Modeling intellectual disability in drosophila
15. Animal models of cerebral dysgenesis: excitotoxic brain injury
16. The effect of age on brain plasticity in animal models of developmental disability
Index.

Contents:
1. Animal models of herpes keratitis
2. Animal models of cataracts
3. Animla models of glaucoma
4. Animal models of age-related macular degeneration: subretinal inflammation
5. Animal models of diabetic retinopathy
6. Animal models of autoimmune uveitis
7. Animal models of retinitis pigmentosa (RP)
8. An animla model of Graves' orbitopathy
9. Animal models of ocular tumors
10. Epilogue
Index.

Contents:
1. Ryan Rostov: A 52-year-old Male with Right Ankle Pain
2. Shirley McCain: A 62-year-old Dance Instructor with Right Foot Pain
3. Anna Coyle: A 24-year-old Dental Hygienist with Severe Medial Ankle Pain
4. Scott English: A 32-year-old Truck Mechanic with Pain and Electric Shock-Like Sensation Radiating into the Dorsum of the Foot
5. Chip Anderson: A 36-year-old Maintenance Man with Numbness and Paresthesias in the Sole of the Foot
6. Paul Reckinger: A 32-year-old Real Estate Agent with Severe Right Ankle Pain with an Associated Catching Sensation
7. DeShawn Freely: A 29-year-old Basketball Player with the Feeling He Had Been Shot in the Ankle
8. Irina Antipova: A 72-year-old Violinist with Right Great Toe Pain
9. Bobby Moltisanti: A 48-year-old Meat Cutter with a Painful Bump on His Big Toe
10. Miranda Halliday: A 24-year-old Fashion Designer with Pain in Her Little Toe
11. Sarah Davidow: A 64-year-old Homemaker with Foot Pain
12. Ross Marquette: A 68-year-old Retired Executive with Severe Posterior Foot Pain
13. Ada Hunt: A 31-year-old Customer Service Representative with Pain in the Arch of the Left Foot
14. Betty Bartholomew: A 32-year-old Pharmacist with Persistent Foot Pain
15. Chuck North: A 32-year-old Veteran with Pain in the Ball of His Foot.

Summary: Ankle injuries are often sport related and pose a diagnostic and therapeutic challenge. Over the past 25 years, Niek van Dijk, founder of the Amsterdam Foot and Ankle School and author of this book, has developed a new philosophy of ankle arthroscopy. It entails a comprehensive approach which includes various diagnostic strategies and the application of a number of minimally invasive endoscopic techniques. The procedures are based on research programs and long-term outcome studies performed at the Orthopaedic Research Center Amsterdam. Use of these techniques has spread throughout the world; they are now recognized as the state of the art and have been used to treat many leading professional athletes. This diagnostic and operating manual presents the Amsterdam Foot and Ankle School approach for a wide variety of ankle and hindfoot problems. Clear step-by-step instructions are provided with the help of numerous high-quality illustrations, most of which are in color. Access to a web-based educational site is also available to readers.

Summary: This book creates a unique platform that covers main ankle pathologies specifically related with football. Experiences from professional players have been combined with evidence-based medical content from renowned experts in the field to present a comprehensive picture on ankle injuries in football. Worldwide, ankle injuries present a high burden for sports medicine physicians, physiotherapists, players, and coaches in and around the football pitch. This book contains updated content for both medical and nonmedical individuals involved with football.

Contents:
1. Anatomy of the Ankle / Pau Golanó, Miquel Dalmau-Pastor, Jordi Vega, and Jorge Pablo Batista
2. Interview - Raul / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
3. Epidemiology and Mechanisms of Ankle Pathology in Football / Ryan L. Anderson, Lars Engebretsen, Nicholas Kennedy, Robert LaPrade, Adam M. Wegner, and Eric Giza
4. Interview - Ricardo Pruna / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
5. Prevention of Ankle Injuries / Miriam van Reijen and Evert Verhagen
6. Interview - Frank de Bleeckere / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
7. Ankle Ligament Lesions / Gino M.M.J. Kerkhoffs, Peter A.J. de Leeuw, Joshua N. Tennant, and Annunziato Amendola
8. Interview - Jan Wouters / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
9. Osteochondral Defects in the Ankle Joint / Rogier Gerards, Maartje Zengerink, and C. Niek van Dijk
10. Interview - Velibor "Bora" Milutinović / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
11. Anterior Ankle Impingement / Johannes L. Tol, Pieter P.R.N. d'Hooghe, Peter A.J. de Leeuw, Mario Maas, and Gino M.M.J. Kerkhoffs
12. Interview - Eva Blewanus / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
13. Posterior Ankle Impingement / Gino M.M.J. Kerkhoffs, Peter A.J. de Leeuw, and Pieter P.R.N. d'Hooghe
14. Interview - Ron Spelbos / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
15. Ankle Fractures, Including Avulsion Fractures / Kyriacos I. Eleftheriou, James D.F. Calder, Peter Kloen, and Pieter P.R.N. d'Hooghe
16. Interview - Leonne Stentler / Pieter P.R.N. d'Hooghe and Gino M.M.J. Kerkhoffs
17. Fifth Metatarsal Stress Fractures in Football / Hanneke Weel, Simon Goedegebuure, Pieter P.R.N. d'Hooghe, and Gino M.M.J. Kerkhoffs
18. Acute Achilles Tendon Rupture / Jon Karlsson, Nicklas Olsson, and Katarina Nilsson Helander
19. Achilles Tendinopathy / Robert Jan de Vos, Pieter P.R.N. d'Hooghe, Peter de Leeuw, and Gino M.M.J. Kerkhoffs
20. Peroneal and Posterior Tibial Tendon Pathology / Hélder Pereira, Pedro Luís Ripoll, Joaquim M. Oliveira, Rui L. Reis, João Espregueira-Mendes, and C. Niek van Dijk
21. The Footballer's Inlay Sole: An Individualised Approach / D.P. Francisco Escobar Ruiz and Pieter P.R.N. d'Hooghe
22. Rehabilitation After Ankle Football Injuries / Mark Feger and Jay Hertel
23. Taping Techniques and Braces in Football / Ruben Zwiers, Leendert Blankevoort, Chris W.A. Swier, A. Claire M. Verheul, and Gino M.M.J. Kerkhoffs
24. Ankle Osteoarthritis in Former Elite Football Players: What Do We Know? / Vincent Gouttebarge and Monique H.W. Frings-Dresen.

Summary: Ankylosing Spondylitis is a chronic autoimmune disease that affects about 1-3% of the world population. This debilitating disease affecting primarily young males exerts considerable socio-economic consequences. The exact pathogenesis of AS has not yet been fully understood; therefore, novel, detailed information sources are required. This book offers cutting-edge knowledge about the molecular basic and immunological mechanisms involved in the pathogenesis of Ankylosing Spondylitis. It is one of the scarce scientific resources discussing the environmental factors triggering the disease, along with the clinical manifestations, diagnostic methods, and treatments. This book covers the most recent and reliable researches and developments about spondyloarthropathies in order to provide elaborated, integrated guidance on the molecular mechanisms of Spondyloarthropathies. It will prove helpful for rheumatologists, immunologists, biologists, geneticists, and medical science students who wish to learn more about SpAs.

Contents:
Part 1 Introduction
1 An overview to Ankylosing spondylitis and Spondyloarthropathies
Part 2 Cells and cytokines
2 Innate Immune-Related Cells and Cytokines in Spondyloarthropathies
3 Adaptive Immune-Related Cells and Cytokines in Spondyloarthropathies
Part 3
4 Association of HLA and HLA Related Genes with Ankylosing Spondylitis
5 Association of non-HLA genes with ankylosing spondylitis
Part 4
Environmental factors
6 Spondyloarthropathies and Gut microbiota
7 Spondyloarthropathies and Food Intake
8 Spondyloarthropathies and Environmental Stresses.

Summary: Records of meetings 1808-1916 in v. 11-27.

Summary: The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Contents:
PROVISIONAL Part I. Respiratory Issues
Part II. ARDS
Part III. Biomarkers
Part IV. Fluids
Part V. Hemodynamic Management
Part VI. An unknown pandemics
Part VII. Covid-19 associated coagulopathy
Part VIII. Sepsis
Part IX. Bleeding & Transfusion
Part X. Prehospital Intervention
Part XI. Neurological Aspects
Part XII. Organ Donation
Part XIII. Oncology
Part XIV. Severe Complications
Part XV. Prolonged Critical Illness
Part XVI. Organizational and Ethical Aspects
Part XVII. Artificial intelligence in the ICU
Index.

Summary: The Annual Update compiles reviews of the most recent developments in clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in intensive care and emergency medicine, anesthesia, surgery, internal medicine, and pediatrics.

Contents:
Intro
Contents
Abbreviations
Part I: Sepsis and the Immune Response
1: The Role of Mitochondria in the Immune Response in Critical Illness
1.1 Introduction
1.2 Mitochondrial Machinery That Mediates and Regulates Immune Responses in Critical Illness
1.2.1 Metabolic Reprogramming
1.2.2 Mitochondrial ROS and mtDNA
1.2.3 Succinate and Itaconate
1.2.4 Mitochondrial Dynamics
1.3 Immunometabolism: The Perfect World Scenario vs. the Critical Illness Scenario
1.4 Potential of Mitochondria-Targeting Therapy in Critical Care 1.5 Challenges of Applying Mitochondria-Targeting Therapy in Critical Care
1.6 Conclusion
References
2: Immunomodulation by Tetracyclines in the Critically Ill: An Emerging Treatment Option?
2.1 Introduction
2.2 Immunopathogenesis of Sepsis
2.3 Immunopathogenesis of ARDS
2.4 Mechanisms of Action of Tetracyclines in ARDS
2.4.1 In Vivo Models
2.4.1.1 Effects on Inflammatory Cytokines and NLRP3 Inflammasome Caspase-1 Signaling
2.4.1.2 Effects on MMPs
2.4.1.3 Effects on Neutrophil Transmigration
2.4.2 Human Data 2.5 Mechanisms of Action of Tetracyclines in Sepsis
2.5.1 In Vitro Models
2.5.1.1 Effects on Cytokine and Chemokine Production
2.5.1.2 Effects on Arachidonic Acid Metabolites and NO Production
2.5.2 In Vivo Models
2.5.2.1 Effects on MAPK Signaling Pathways and Inflammatory Mediators
2.5.2.2 Effects on Organ Dysfunction
2.5.3 Human Data
2.6 Future Research Perspectives
2.7 Conclusion
References
3: Hit Early: Blocking Interleukin-1 in the Treatment of COVID-19 Pneumonia
3.1 Introduction
3.2 Cytokines and Disease Progression in COVID-19 3.3 Contribution of Monocytes and Macrophages in Early Cytokine Response
3.4 How Can Early Activation of IL-1 Be Identified?
3.5 SAVE Strategy: Early Blockade of IL-1 Guided by Biomarkers
3.6 Conclusion
References
4: Hemoadsorption Therapy During ECMO: Emerging Evidence
4.1 Introduction
4.2 Devices and Implementation
4.3 Hemoadsorption in Combination with ECMO
4.4 Hemoadsorption in Severe COVID-19 Supported with ECMO
4.5 Discussion and Outlook
4.6 Conclusion
References
Part II: Respiratory Issues 5: The Forgotten Circulation and Transpulmonary Pressure Gradients
5.1 Introduction
5.2 Pulmonary Vessel Anatomy
5.3 Pulmonary Vascular Dysfunction
5.4 Pulmonary Circulation and Its Components
5.4.1 The Transpulmonary Driving Pressure: A Small Gradient with Big Importance
5.4.2 Pulmonary Vascular Resistance and 'Closing Pressures'
5.5 Measuring the Transpulmonary Pressure Gradient
5.6 The Evolving Role of Pulmonary Arterial Compliance
5.7 Relevant Clinical Scenarios in Critical Illness
5.7.1 Pulmonary Hypertension
5.7.2 Right Ventricular Dysfunction

Summary: This book brings together lessons learned in the clinical use of anorectal endosonography and manometry in paediatrics. In contrast to adult medicine, where they are virtually indispensable for specialists dealing with colo-proctology, in paediatrics endoanal ultrasound and anorectal manometry are still the prerogative of very few international centres. This book collects the results of a Workshop organised at the Paediatric Surgery Unit of Bologna, entitled "International Seminar on Endosonography and Anorectal Manometry in Paediatrics", and presents contributions from leading European experts. Focusing on the paediatric age group, this volume fills a gap in the paediatric gastroenterology literature, and will benefit all specialists wishing to use these methods in the management and treatment of common clinical problems, e.g. chronic constipation.

Contents:
1 History of Endocavitary Ultrasound
Basics of Endoanal Ultrasounds
3 Principles of Ano-Rectal Manometry
4 Surgical and Functional Anatomy of The Pelvic Floor and the Ano-Rectum
5 Physiology of the Pelvic Floor and the Ano-Rectum
6 Normal Endosonographric Features of the Anal Canal
7 Ano-Rectal Manometry, Conventional and High Resolution
8 Ano-Rectal Malformations: Ano-Rectal Manometric and Endosonographic Combined Approach
9 Suppurative Processes of the Ano-Rectal Region: Endoanal Ultrasonographic Assistence
10 Chronic Constipation in Paediatrics: Pathophysiology and Diagnosis
11 Treatment of Chronic Constipation in Paediatrics
12 Echo-Assisted Botulinum Injection
13 Ano-Rectal Manometry and Endoanal Ultrasonography in Paediatric Incontinence
14 Echo-Assisted Ano-Lipofilling
15 Endoanal Ultrasonography in Male and Female Genitalia Malformations
16 Endoanal Ultrasonography: Use on Adults.

Contents:
Intro
Foreword
Preface
Contents
Contributors
Part I: Clinical Foundations
Chapter 1: Introduction and Historical Perspectives
Introduction
Early Historical Perspectives
Extirpation
Enucleation
Evisceration
Exenteration
Conclusion
References
Chapter 2: Clinical Decision-Making
Introduction
Indications for Eye Removal
Infectious
Neoplastic
Traumatic
Palliative
Choice of Surgical Technique
Further Reading
Chapter 3: Sympathetic Ophthalmia
Introduction
Background: Epidemiology and Risk Factors
Reduction of Risk of SO Presentation and Diagnosis
Management
References
Chapter 4: Psychological and Cognitive Adjustment to Vision Loss
References
Chapter 5: History of Ocular Implants
Prehistory/Before Ocular Implants
The First Ocular Implant
The Emergence of Acrylics
In Search of Increased Motility
The Advent of Porous Orbital Implants
Looking to the Future
References
Part II: Surgical Techniques
Chapter 6: Enucleation and Techniques of Orbital Implant Placement
Background
Indications
Surgical Procedure
Types of Implants
Implant Placement Preparation of Implant
Placement of Implant
Peg Placement
Complications
References
Chapter 7: Evisceration
Introduction
Preoperative Considerations
Surgical Technique
Implant Placement
Sympathetic Ophthalmia
References
Chapter 8: Exenteration and Multidisciplinary Approaches
Indications
Preoperative Evaluation
Operative Technique
Healing by Second Intention
Split-Thickness Skin Graft
Dermal Substitute
Myocutaneous Advancement Flap or Free Flap
Potential Complications
Postoperative Care
References Chapter 9: Orbital Implants and Wrapping Materials
Introduction
Implant Size
Special Considerations
Implant Material
Nonporous Implants
Silicone
Polymethyl Methacrylate
Porous Implants
Porous Hydroxyapatite
Porous Polyethylene
Aluminum Oxide
Special Considerations
Wrapping Materials
Pegging
References
Chapter 10: Osseous Integration After Exenteration
Historical Perspective
Definition and Biology of Osseointegration
Factors Influencing Success of Osseointegration
Implant Material
Implant Design and Surface Characteristics Bone Quality
Surgical Technique
Preoperative Evaluation
Procedure Description
Primary Stability
Post-op Care
Success of Orbital Implant Osseointegration
Radiotherapy and Osseointegration
Effect of Radiation on Bone
Dose of Radiotherapy
Success of Osseointegration in Irradiated Bone
Hyperbaric Oxygen Therapy
Advantages of Osseointegration [7, 20, 23]
Disadvantages of Osseointegration [7, 20, 23]
Management of Possible Complications
Soft Tissue Reaction and Infection
Soft Tissue Growth Up Against the Bar the Bar
Osseointegration Failure

Summary: This is the first comprehensive book exclusively dedicated to anorectal physiology and the importance of diagnostic tools in guiding the evaluation and treatment of anorectal dysfunction. Functional disorders, and specifically fecal incontinence and evacuatory disorders, are prevalent in the general population, affecting up to 20% of individuals. As many of these conditions have extremely complex mechanisms, a thorough understanding of anorectal physiology is a crucial element in the surgeon's "arsenal" to ensure accurate evaluation and to inform treatment. At this time, there is no other title that specifically addresses all aspects of anorectal physiology, as well as anorectal and pelvic floor disorders, including fecal incontinence and defecation disorders. Specifically, the book provides detailed descriptions of diagnostic methods and treatment algorithms for a range of anorectal conditions, including modern treatment modalities such as sacral neuromodulation. A unique and comprehensive reference covering all aspects of the evaluation and treatment of anorectal disorders, Anorectal Physiology - A Clinical and Surgical Perspective will be of significant interest to proctologists and coloproctologists, gastroenterologists, colorectal surgeons, gynecologists and all other professionals interested in anorectal physiology.

Contents:
Anatomy of the anorectal region and pelvic floor
Physiology of Continence and Defecation
New concepts of anorectal anatomy, physiology and surgery according to the Integral System
Clinical Evaluation of Continence and Defecation
Introduction to Methods of Anorectal Physiology Evaluation
Particulars of anal Manometry
Endoanal, endovaginal and transperineal ultrasound
Echodefecography: Technique and Clinical Application
Cinedefecography
MRI Defecography
Neurophysiology of the Pelvic Floor
Electromyography and Pudendal Nerve Terminal Motor Latency
Anal Incontinence: Etiology and Clinical Treatment
Anal incontinence: Minimally Invasive Options
Stem cells: the state of cellular therapy in treatment of fecal incontinence
Surgical Treatment of Fecal Incontinence
Complex Procedures for Fecal Incontinence
Constipation
Obstructed Defecation Syndrome
Defecation disorders in children and adolescents
Anal Manometry and Chagasic colopathy
New Functional Concepts of Chagas Disease
Functional Aspects of Diabetes and Collagenosis
Solitary Rectal Ulcer Syndrome.-Multiple Approaches for the Treatment of Rectoceles
Rectal Prolapse
Enterocele: Diagnosis and treatment
Ventral Rectopexy: Indications, Surgical Considerations and Outcomes
Pudendal neuropathy and pudendal canal decompression
Anorectal and pelvic floor pain syndromes
Neurogenic Bowel and Bladder Dysfunction
Anorectal Physiology in Low Rectal Resection Syndrome
Treatment of the low anterior resection syndrome
Pelvic Floor Rehabilitation
Biofeedback
Sacral neuromodulation
Sacral Neuromodulation for Anorectal Dysfunction
Technical Aspects of Sacral Neuromodulation
Posterior Tibial Nerve Stimulation
Pelvic Floor Dysfunction.

Summary: "To some, food allergies seem like fabricated cries for attention. For others, they pose a dangerous health threat. Food allergies are bound up with so many personal and ideological concerns that it is difficult to determine what is medical and what is myth. This book parses the political, economic, cultural, and genuine health factors of a phenomenon that now dominates our interactions with others and our understanding of ourselves. Surveying the history of food allergy from ancient times to the present, Another Person's Poison also gives readers a clear grasp of new medical findings on allergies and what they say about our environment, our immune system, and the nature of the food we consume. For most of the twentieth century, food allergies were considered a fad or junk science. While many physicians and clinicians argued that certain foods could cause a range of chronic problems, from asthma and eczema to migraines and hyperactivity, others believed that allergies were psychosomatic. Another Person's Poison traces the trajectory of this debate and its effect on public-health policy and the production, manufacture, and consumption of food. Are rising allergy rates purely the result of effective lobbying and a booming industry built on self-diagnosis and expensive remedies? Or should physicians become more flexible in their approach to food allergies and more careful in their diagnoses? Exploring the issue from scientific, political, economic, social, and patient-centered perspectives, this book is the first to engage fully with the history of what is now a major modern affliction, illuminating society's troubled relationship with food, disease, and the creation of medical knowledge."--Book jacket.

Contents:
Introduction: "Witchcraft, a fad, or a racket?"
Food allergy before allergy
Anaphylaxis, allergy, and the food factor in disease
Strangest of all maladies
Panic? or the pantry?
An immunological explosion?
The problem with peanuts.

Contents:
Comprehensive guide to steam sterilization and sterility assurance in health care facilities
ANSI/AAMI ST79:2017, Comprehensive guide to steam sterilization and sterility assurance in health care facilities, Amendment 1: Environmental services/fans/food and drink
ANSI/AAMI ST79:2017, Comprehensive guide to steam sterilization and sterility assurance in health care facilities, Amendment 2: Inspection of insulated instruments
ANSI/AAMI ST79:2017, Comprehensive guide to steam sterilization and sterility assurance in health care facilities, Amendment 3: Modification of content pertaining to frequency of cleaning for routine care of sterilizers for sterile processing areas in health care facilities
ANSI/AAMI ST79:2017, Comprehensive guide to steam sterilization and sterility assurance in health care facilities, Amendment 4: Content addressing recording BI lot numbers in sterilizer records for sterile processing in health care facilities.

Summary: "Dear White women... In the lives of Black women, women of color, you are an Antagonist, Advocate, or Ally. This is your wake up call; a dramatically sobering reality check to wake you up from the detrimental denial of your White Privilege. Antagonists, Advocates and Allies delivers uncomfortable truths and painful realities about the conscious and unintentional pain you have inflicted on Black women, women of color and shares how you must use your power to eliminate racism and stop the hypocrisy within the feminine movement."--Page 4 of cover.

Contents:
Awakened to difference
The mysterious Western woman
The antagonist
The advocate
The white privileged woman
Intersectionality: the crossroad between race and gender
Misappropriation of culture
Becoming a white ally
Cliques, catfights and colorblindness
So now what?

Summary: Seaweeds (macroalgae) represent the most striking living components in the Antarctic's near-shore ecosystems, especially across the West Antarctic Peninsula and adjacent islands. Due to their abundance, their central roles as primary producers and foundation organisms, and as sources of diverse metabolically active products, seaweed assemblages are fundamental to biogeochemical cycles in Antarctic coastal systems. In recent years, the imminence of climate change and the direct impacts of human beings, which are affecting vast regions of the Antarctic, have highlighted the importance of seaweed processes in connection with biodiversity, adaptation and interactions in the benthic network. Various research groups have been actively involved in the investigation of these topics. Many of these research efforts have a long tradition, while some "newcomers" have also recently contributed important new approaches to the study of these organisms, benefiting polar science as a whole. This book provides an overview of recent advances and insights gleaned over the past several years. Focusing on a timely topic and extremely valuable resource, it assesses the challenges and outlines future directions in the study of Antarctic seaweeds.

Contents:
Intro
Preface
Foreword
Contents
Part I: Introduction
Chapter 1: Antarctic Seaweeds: Biogeography, Adaptation, and Ecosystem Services
1.1 Introduction: The Historical Context
1.2 Antarctic Seaweeds in the Wake of Climate Change
1.3 The Book
1.3.1 Diversity and Biogeography
1.3.2 Environment and Ecophysiology
1.3.3 Ecological Functions
1.3.4 Chemical Ecology
1.4 Gaps, Emerging Challenges, and Future Directions
References
Part II: Diversity and Biogeography
Chapter 2: Diversity of Antarctic Seaweeds
2.1 The Antarctic Environment 2.2 Seaweeds in Antarctica: Definition and Importance
2.3 Seaweed Taxonomic Studies in Antarctica: Toward a New Species Compilation
2.4 Molecular Taxonomy for the Study of Antarctic Seaweed Diversity
2.5 Seaweed Distribution in Antarctica
2.6 Concluding Remarks: Gaps and Prospects for the Future
References
Chapter 3: Biogeographic Processes Influencing Antarctic and sub-Antarctic Seaweeds
3.1 Antarctica's Place in the World: An Isolated Continent?
3.1.1 Adaptations of Terrestrial Organisms to Antarctic Conditions 3.1.2 Adaptations of Marine Organisms to Antarctic Conditions
3.1.3 Evidence for Dispersal of Organisms into the Antarctic
3.2 Physical Oceanographic Processes Influencing Movement of Seaweeds into or out of the Antarctic
3.2.1 Ekman Transport
3.2.2 Eddies
3.2.3 Wave-Driven Stokes Drift
3.2.4 Surface Currents
3.3 Hitch-Hiking to the Antarctic: Passengers on Seaweed Rafts
3.3.1 Characteristics of Rafting Species
3.3.2 Processes Affecting Establishment of New Taxa in the Antarctic
3.4 Concluding Remarks
References 5.3 Seaweed Assemblages: Are Antarctic Seaweed Diversity and Richness Changing?
5.4 The Physiological Bases of Macroalgal Shifts
5.5 Deception Island: A Case Study of Opportunistic, Alien, Cryptic and Cryptogenic Species
5.6 Reevaluating Eco-Regions, Isolation, and Endemism in the Southern Ocean
5.7 Concluding Remarks: Prospects for the Future Marine Flora of the Southern Ocean
References
Chapter 6: Comparative Phylogeography of Antarctic Seaweeds: Genetic Consequences of Historical Climatic Variations
6.1 Historical Isolation of Antarctic Marine Macroalgae Chapter 4: Detached Seaweeds as Important Dispersal Agents Across the Southern Ocean
4.1 Introduction
4.2 Detached Seaweeds in Antarctica
4.3 Abiotic Factors Influencing Floating Seaweeds
4.4 Biotic Factors Affecting Floating Seaweeds
4.5 Physiology of Floating and Drifting Seaweeds: Traspassing Thermal Barriers
4.5.1 Out of Antarctic: Is it Physiologically Feasible?
References
Chapter 5: Biogeography of Antarctic Seaweeds Facing Climate Changes
5.1 The Abiotic Setting of the Southern Ocean
5.2 Biogeographic Patterns

Summary: The minimally invasive, anterior-based muscle-sparing (ABMS) approach to total hip arthroplasty (THA) is utilized worldwide in select locations as an effective surgical technique. As the name suggests, it is completely muscle-sparing and touts the benefits of anterior-based surgery, including a lower dislocation rate, quicker return to baseline function, and lower narcotic use than many other surgical approaches. However, there is a paucity of collected information on the technique and research associated with this technique. This text serves as a compendium of information for those surgeons interested in utilizing this surgical approach as an all-inclusive reference. As an alternative anterior-based approach to the direct anterior surgical approach, some surgeons may find the technique an improved alternative for anterior hip-based surgery. Opening chapters present the history of the anterolateral approach and how to transition to the ABMS approach, including surgical anatomy. ABMS technique with the patient positioned in both the lateral and supine positions are then presented, including associated video segments. Considerations such as implant selection, fixation, and other tips and tricks are shared, along with comparisons to other approaches, patient-reported outcomes, complications and revision surgery techniques, and rehabilitation strategies. For hip surgeons looking to expand their armamentarium of surgical approaches, The Anterior-Based Muscle-Sparing Approach to Total Hip Arthroplasty is a terrific resource.

Contents:
The idea of "Minimally Invasive Solution" total hip arthroplasty: History and perspective behind the modernization of surgery through the Watson-Jones muscle interval
Transitioning to the ABMS Approach
Surgical anatomy and approach
The ABMS Total Hip Replacement, performed in the Lateral Position
The ABMS Approach to Total Hip Replacement in the Supine Position
Outpatient Total Hip Arthroplasty using an ABMS Approach
Cementless ABMS Total hip replacement
Cemented ABMS Total hip replacement
Implant Selection in ABMS Total Hip Replacement surgery
Tips & Tricks to Overcome the Learning Curve of the ABMS Approach to the Hip
Surgical Navigation in the ABMS Approach to Total Hip Replacement
Comparison of the ABMS Approach to Other Surgical Approaches for Total Hip Replacement
Periprosthetic Joint Infection treatment through the ABMS
How to Avoid Complication in the ABMS Total hip replacement
Acetabular Revision THR using the ABMS approach
Femoral Revision THR using the ABMS approach
Total Hip Replacement for Fragility Fractures Using the ABMS in the Older Adult
Outcomes of ABMS THA
Rehabilitation after THR using the ABMS approach.

Summary: "Anterior controllable antedisplacement and fusion (ACAF) is becoming globally regarded as the go-to operative technique for the treatment of ossification of spine ligaments (OSL). Suitable for spinal surgeons and rehabilitation physicians at all levels, this timely reference can help make the surgical intervention of OSL much safer, easier, and more effective. It offers thorough case presentations and discussions on the application of ACAF in the treatment of OSL, ossification of posterior longitudinal ligament (OPLL), ossification of ligamentum flavum (OLF), and spinal stenosis"-- publisher's description.

Contents:
Principles of the anterior controllable antedisplacement and fusion technique
Procedures of the Anterior controllable antedisplacement fusion technique
Case series.

Summary: This practical and instructional guidebook, written by international experts in anterior cruciate ligament (ACL) reconstruction, covers all challenging aspects of ACL rupture in the acute and chronic setting. It covers the latest, spectacular anatomical findings, treatment of partial ACL tears, various techniques for single- and double-bundle ACL reconstruction, and complex ACL revision surgery. Important surgical steps are clearly described with the help of instructive, high-quality photographs. Important tips, tricks, and pitfalls are highlighted and intra- and postoperative complications, rehabilitation, and prevention of re-rupture are discussed. All authors are prominent and experienced ACL surgeons.

Contents:
Part I. Anatomy
1. Ribbonlike Anatomy of the Anterior Cruciate Ligament from Its Femoral Insertion to the Midsubstance / Robert Śmigielski, Urszula Zdanowicz, Michał Drwięga, Bogdan Ciszek, and Rainer Siebold
2. Anatomic and Histological Analysis of the Midsubstance and Fanlike Extension Fibers of the ACL / Tomoyuki Mochizuki, Akimoto Nimura, Kazunori Yasuda, Takeshi Muneta, and Keiichi Akita
3. Tibial C-Shaped Insertion of the Anterior Cruciate Ligament Without Posterolateral Bundle / Rainer Siebold, Peter Schuhmacher, Axel Brehmer, Francis Fernadez, Robert Śmigielski, and Joachim Kirsch
4. Variations of the Tibial Insertion of the Anterior Cruciate Ligament: An Anatomical Study / Robert Śmigielski, Urszula Zdanowicz, Michał Drwięga, Bogdan Ciszek, Christian Fink, and Rainer Siebold
5. Arthroscopic Appearance of the “C”-Shaped Insertion of the Anterior Cruciate Ligament / Rainer Siebold and Robert Śmigielski
Part II. Biomechanics
6. Biomechanics of the Knee with Intact Anterior Cruciate Ligament / Milos Dordevic and Michael T. Hirschmann
7. Injury Mechanisms of ACL Tear / Milos Dordevic and Michael T. Hirschmann
8. Biomechanics of the Knee After Complete and Partial ACL Tear / Milos Dordevic and Michael T. Hirschmann
Part III. ACL Augmentation
9. History, Physical Examination and Imaging / Mark Bergin, Marcus Hofbauer, Bruno Ohashi, and Volker Musahl
10. Arthroscopic Assessment of Partial ACL Tears / Rainer Siebold
11. Conservative versus Operative Treatment / Jürgen Höher and Christoph Offerhaus
12. Reasons for ACL Augmentation / Philippe Colombet and Rainer Siebold
13. Surgical Technique / Bertrand Sonnery-Cottet, Philippe Colombet, Rainer Siebold, Pooler Archbold, Pierre Chambat, Jacopo Conteduca, and Mathieu Thaunat
14. Literature Results / Bertrand Sonnery-Cottet, Jacopo Conteduca, Pooler Archbold, and Mathieu Thaunat
Part IV. Single Bundle ACL Reconstruction
15. Diagnostics / Rainer Siebold, Volker Musahl, Yuichi Hoshino, Christopher D. Murawski, and Georgios Karidakis
16. Timing of ACL Surgery: Any Evidence? / Michael E. Hantes and Alexander Tsarouhas
17. Graft Harvest and Preparation / Juan Carlos Monllau, Wolf Petersen, Christian Fink, Sven U. Scheffler, Pablo Eduardo Gelber, and Christian Hoser
18. Tibial Bone Tunnel Placement (Arthroscopically and with Fluoroscopy) / Christophe Hulet, Goulven Rochcongar, and Valentin Chapus
19. Femoral Bone Tunnel Placement (Arthroscopically and with Fluoroscopy) / Tim Spalding, Curtis Robb, and Charles H. Brown Jr.
20. Fluoroscopy for Bone Tunnel Placement / Rainer Siebold and Hans H. Pässler
21. Bone Tunnel Drilling / Wolf Petersen, Rainer Siebold, Bertrand Sonnery-Cottet, Jacopo Conteduca, Pooler Archbold, Mathieu Thaunat, and Pierre Chambat
22. ACL-Footprint Reconstruction with Insertion Site Table / Rainer Siebold and Peter Schuhmacher
23. Tensioning of Grafts: Any Evidence? / Sven U. Scheffler
24. Fixation / Giuseppe Milano, Wolf Petersen, Juergen Hoeher, Hans H. Paessler, Ralph Akoto, Vincenzo Campana, Maristella F. Saccomanno, and Rainer Siebold
25. Remodeling of Hamstring Tendon Grafts After ACL Reconstruction / Rob P.A. Janssen and Sven U. Scheffler
26. Semitendinosus and Gracilis Tendon Regeneration Following Harvest / Martina Åhlén, Mattias Lidén, and Jüri Kartus
27. Long-Term Outcome of ACL Reconstruction / Steven Claes, Rene Verdonk, Johan Bellemans, and Peter C. Verdonk
Part V. Double Bundle ACL Reconstruction
28. Double-Bundle ACL Reconstruction with Hamstrings / Timo Järvelä and Rainer Siebold
29. "Ribbonlike" Double-Bundle ACL Reconstruction with Restoration of "C"-Shaped Tibial Insertion Site / Rainer Siebold
Part VI. ACL Reconstruction with Extra-articular Stabilisation
30. ACL Reconstruction with Extra-articular Plasty / David Dejour, Stefano Zaffagnini, Panagiotis G. Ntagiopoulos, Alberto Grassi, Giulio Maria Marcheggiani Muccioli, and Maurilio Marcacci
31. Extra-articular Augmentation of Anterior Cruciate Ligament Reconstruction: The Monoloop Procedure / Cathal J. Moran, Peter C. Verdonk, Koen Lagae, and Geert DeClercq
Part VII. ACL and Open Physis
32. ACL Rupture with Open Physis / Karl-Heinz Frosch, Romain Seil, Rainer Siebold, Franck Chotel, Shinya Oka, and Achim Preiss
33. Bony Avulsion with Open Physis / Elisabeth Abermann, Peter Gföller, Christian Hoser, and Christian Fink
Part VIII. One-Stage Revision
34. Systematic Approach from Porto School / Hélder Pereira, Nuno Sevivas, Rogério Pereira, Alberto Monteiro, Ricardo Sampaio, Joaquim Miguel Oliveira, Rui Luís Reis, and João Espregueira-Mendes
35. One-Stage Revision: Danish Approach / Martin Lind
Part IX. Spongiosaplasty and Two-Stage Revision
36. ACL Two-Stage Revision Surgery: Practical Guide / João Espregueira-Mendes, Hélder Pereira, Alberto Monteiro, Joaquim Miguel Oliveira, Rui Luís Reis, Pedro Luís Ripóll, and Neil Thomas
37. Bone Harvest from Iliac Crest and Bone Tunnel Filling / Rainer Siebold and Hans H. Pässler
Part X. ACL + Osteotomy
38. Surgical Technique / Pedro Pessoa
39. Results of Combined High Tibial Osteotomy (HTO) and ACL Reconstruction / Christophe Hulet, Aude Sebilo, and Sylvie Collon
Part XI. Intraoperative Complications
40. Intraoperative Complications: Solutions? / Mohsen Hussein
Part XII. Postoperative Complications
41. Postoperative Complications: Solutions? / Jüri Kartus, Francis Fernandez, and Rainer Siebold
Part XIII. Rehabilitation and Prevention
42. Rehabilitation and Return to Sports / Amelie Stoehr, Hermann Mayr, Barbara Wondrasch, and Christian Fink
43. Prevention of ACL Tear and Rerupture / Amelie Stoehr, Barbara Wondrasch, and Hermann Mayr.

Summary: Anterior hip replacement is a surgical approach that has dramatically changed the landscape of modern hip replacement. The approach is common to orthopedic trauma surgery, but it has been rapidly adopted in recent years for hip replacement as well. Its proposed benefits as a muscle-sparing surgery include less tissue trauma, faster recovery, and fewer hip precautions. While the technique can be challenging during initial learning and early adoption, the approach continues to increase in utilization in the U.S. every year because of these benefits. Understanding the initial development of the anterior surgical approach for hip replacement creates the foundation to better understand its modern clinical benefits and possibilities with advanced techniques. Furthermore, a detailed description of the reasoning behind the continued developments of the anterior approach helps in understanding the key elements needed to obtain the most successful outcomes. With the continued adoption of this technically challenging technique, there is a need for a comprehensive resource for newly adopting surgeons and surgeons in training, but also for experienced surgeons looking to enhance their skill sets. Written by experts in the field, this book presents the tips and tricks learned after years of experience by a wide spectrum of surgeons. Parts 1 and 2 describe the origin and background of the anterior approach for hip replacement, with early lessons learned, important tips when training others, and how to master the operating table and c-arm. Parts 3 and 4 cover hip biomechanics and variations on techniques and technologies, respectively, while part 5 is a unique compilation of surgeons' perspectives on managing common aspects of the approach. Revision surgery is described in part 6, and future directions for the technique are discussed in part 7, along with emerging navigation and technologies. Every year, there is an increasing number of orthopedic surgeons learning and adopting the anterior hip approach who would benefit from the resources in this book, which will serve as a critical learning tool for training surgeons and also as the go-to reference for optimizing current use and advancing future possibilities of the approach.

Contents:
Part 1. The Origins of the Anterior Hip Surgical Approach
1. The French Beginning and Judet School of the Anterior Approach
2. My French and American Beginning and Evolution of the Anterior Approach
Part II. The Anterior Approach: An Established and Repeatable Technique
3. The Anterior Approach Surgical Technique for Total Hip Arthroplasty: The "Matta Method" of 2020
4. Understanding the Modern Surgeon's Transition to Anterior Hip Replacement
5. The Learning Curve for the Anterior Approach: Early, Middle, and How It Continues
6. Introducing the Direct Anterior Approach (DAA) at a Swiss University Hospital
7. Challenges in Anterior Approach Education
8. Why I Favor a Standard Incision and Keys to Exposure for the Anterior Approach
9. Anterior Approach to the Hip Through the Oblique "Bikini" Incision
10. My Keys to Getting the Acetabulum Right with the Anterior Approach: Exposure, Preparation, Sizing, Position, Stability
11. My Keys to Getting the Femur Right with the Anterior Approach: Exposure, Preparation, Sizing, Depth of Insertion of Stem, Ball Head, Stability
12. Diagnosing and Managing Complications from the Anterior Approach
13. Tips and Tricks for Your First Anterior Hip Replacement
14. OR Efficiency: Radical Time Transparency and Operational Excellence
15. Results of the Direct Anterior Approach for Total Hip Arthroplasty
16. Difficult Cases in Primary Anterior Total Hip Arthroplasty
17. Direct Anterior Approach THA for Treatment of Femoral Neck and Acetabular Fractures
18. Anterior Approach Total Hip Arthroplasty Following Previous Femoral and Acetabular Fractures
Part III. Hip Biomechanics: What Are We Trying to Achieve?
19. Normal Hip Biomechanics
20. Key Concepts and Methods for Acetabular Positioning
21. Understanding Leg Length and Offset
Part IV. The Anterior Approach: The Variation of Techniques and Technologies
22. The Anterior Approach: From Robert Judet’s Work to AMISª (Anterior Minimally Invasive Surgery)
23. The History of the Direct Anterior Approach in Innsburck
24. The Direct Anterior Approach on a Standard Table in Zurich
25. A Hybrid Technique with a Standard Table and Mechanical Leg Holder
26. My Continued Evolution of the Anterior Approach
Part V. Controversies in the Anterior Approach: Surgeon Perspectives
27. The Orthopedic Table versus the Standard OR Bed for the Anterior Approach
28. Handling the Hip Capsule with the Anterior Approach: Repair versus Capsulectomy
29. Judging Leg Length and Offset with the Anterior Approach: Clinical Evaluation versus Fluoroscopy
30. Does Pelvic Tilt Change Anything with the Anterior Approach?
31. Getting Correct Cup Position with the Anterior Approach: Bony Landmarks versus X-ray versus Computer Guidance
32. Stem Choice for Anterior Approach Total Hip Arthroplasty: Surgeon Perspectives
33. Hip Resurfacing Arthroplasty Using the Hueter-Anterior Approach
Part VI. Revision Surgery Using the Anterior Hip Approach
34. Revision Surgery Exposure Techniques for the Anterior Hip Approach, Including Osteotomies
35. Complex Femoral Revision Using the Direct Anterior Hip Approach
36. Femoral Revision Total Hip Arthroplasty Using the Direct Anterior (Hueter) Approach
37. Complex Acetabular Reconstruction Using the Direct Anterior Approach
38. Treatment of Acute and Late Infections Using the Direct Anterior Approach
Part VII. Future Directions in Techniques and Technology for the Anterior Approach
39. Navigation Technologies for the Anterior Approach in Total Hip Arthroplasty
40. Robotic Total Hip Replacement with Direct Anterior Approach
41. Problems to Solve and Potential Future Directions for Anterior Approach Total Hip Arthroplasty.

Summary: "This book covers recent substantial improvements in diagnosis and treatment of anterior skull base tumors. This has been fostered by the introduction and rapid expansion of transnasal endoscopic techniques, in parallel with extraordinary progress made in all the other disciplines (pathology, radiology, neurosurgery, radiation oncology, medical oncology) which are involved in the complex process of managing these tumors. Chapters address nuances of treatment in relation to histology, as well as present views on selection criteria for surgical techniques"-- Provided by publisher.

Contents:
Macroscopic and Endoscopic Anatomy of the Anterior Skull Base and Adjacent Structures / Ferrari M., Mattavelli D., Schreiber A., Nicolai P.
Pathology and Differential Diagnosis of Anterior Skull Base Tumours / Williams M.D., El-Naggar A.K.
The Role of Morphologic and Functional Imaging in Pretreatment Assessment / Maroldi R., Borghesi A., Ravanelli M., Golemi S., Farina D.
Transnasal Endoscopic Surgery : Surgical Techniques and Complications / Battaglia P., Lambertoni A., Castelnuovo P.
Anterior Skull Base Surgery in the 21st Century : The Role of Open Approaches / Abu-Ghanem S., Shilo S., Yehuda M., Abergel A., Safadi A., Fliss D.M.
Update of Radiation Techniques Using Photons for Anterior Skull Base Tumors / Foster C.C., Kim J.K., Melotek J.M., Lee N.Y.
The Evolving Role of Systemic Therapy in the Primary Treatment of Sinonasal Cancer / Licitra L., Resteghini C., Bossi P.
Particle Therapy : Protons and Heavy Ions / Jensen A.D.
Benign Tumors of the Anterior Cranial Base / Snyderman C.H., Lavigne J.P.
Endoscopic Endonasal Approaches for Anterior Skull Base Meningiomas / Todeschini A.B., Beer-Furlan A., Otto B., Prevedello D.M., Carrau R.L.
Squamous Cell Carcinoma and Its Variants / Mani N., Shah J.P.
A Comprehensive Update on Intestinal- and Non-Intestinal-Type Adenocarcinomas / Vander Poorten V., Jorissen M.
Olfactory Neuroblastoma / Veyrat M., Vérillaud B., Fiaux-Camous D., Froelich S., Bresson D., Nicolai P., Herman P.
Neuroendocrine Carcinoma and Sinonasal Undifferentiated Carcinoma / Abdelmeguid A.S., Bell D., Hanna E.Y.
Sinonasal Malignant Melanoma / Lund V.J.
Adenoid Cystic Carcinoma Involving Paranasal Sinuses and the Skull Base / Castelnuovo P., Turri-Zanoni M.
Other Rare Sinonasal Malignant Tumours Involving the Anterior Skull Base / Naga R., Pai P.S.
Post treatment Imaging Surveillance / Farina D., Zorra I., Golemi S., Lombardi D., Borghesi A., Maroldi R., Ravanelli M.
Treatment Options for Recurrent Anterior Skull Base Tumors / Orlandi E., Iacovelli N.A., Ingargiola R., Resteghini C., Bossi P., Licitra L., Ferrari M., Nicolai P.
Future Perspectives in the Management of Tumors of the Anterior Skull Base / Nicolai P., Bradley P.J., Bossi P., Ferrari M.

Summary: This book comprehensively discusses anterolateral rotatory instability in the ACL deficient knee, exploring anatomy, biomechanics, diagnostics, clinics, surgical techniques as well as short and long term outcomes. The author also offers an historical perspective ranging from the birth of modern anterior cruciate ligament surgery to the renewed global interest towards the role of secondary restraints and extra-articular reconstructions. Step-by-step guidance throughout each surgical technique further equips the reader to handle this complex condition. Covering all theoretical and practical aspects, as well as future perspectives, this book is a must-read for all orthopedic surgeons and sports physicians wanting to gain insights into this promising field.

Contents:
History of Modern ACL Surgery
Anatomy of Secondary Restraints of ACL
Biomechanics of Anterolateral Instability and Pivot Shift
Surgical Anatomy in ACL Tears
The Segond's Fracture
The Unhappy Triad Revisited
Mechanism of Injury of ACL Tears
Diagnostics in ACL-Deficient Knee
Why the Semitendinosus?
Extra-Articular Reconstructions in ACL-Deficient Knee
Revision ACL Reconstructions
Anterolateral Instability and Osteoarthrosis
Clinical Results in ACL Surgery
Future Directions: ACL Repair vs Reconstruction.

Summary: This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors -- both internationally respected anthropologists and new voices -- demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals' and lay people’s intimate encounters with policy. Authors look closely at core policy debates in the history of global maternal health across six different continents, including: Women's use of misoprostol for abortion in Burkina Faso The place of traditional birth attendants in global maternal health Donor-driven maternal health programs in Tanzania Efforts to integrate qualitative evidence in WHO maternal and child health policy-making Anthropologies of Global Maternal and Reproductive Health will engage readers interested in critical conversations about global health policy today. The broad range of foci makes it a valuable resource for teaching in medical anthropology, anthropology of reproduction, and interdisciplinary global health programs. The book will also find readership amongst critical public health scholars, health policy and systems researchers, and global public health practitioners.

Contents:
Chapter 1. Introduction Lauren J. Wallace, Margaret E. MacDonald & Katerini T. Storeng
Part I. Implementation Disconnects and Policy Rhetoric
Chapter 2. Baby (not so) Friendly: Implementation of the Baby-Friendly Hospital Initiative in Serbia Ljiljana Pantović
Chapter 3. The Promise and Neglect of Follow-up Care in Obstetric Fistula Treatment in Uganda Bonnie Ruder & Alice Emasu
Chapter 4. The Domestication of Misoprostol for Abortion in Burkina Faso: Interactions Between Caregivers, Drug Vendors and Women Seydou Drabo
Chapter 5. The 'Sustainability Doctrine' in Donor-Driven Maternal Health Programs in Tanzania Meredith G. Marten
Part II. Policy Ambivalence
Chapter 6. The Place of Traditional Birth Attendants in Global Maternal Health: Policy Retreat, Ambivalence, and Return Margaret E. MacDonald
Chapter 7. Conflicted Reproductive Governance: The Co-existence of Rights-Based Approaches and Coercion in India’s Family Planning Policies Maya Unnithan
Part III. Contesting Authoritative Knowledge and Practice
Chapter 8. Regulating Midwives: Foreclosing Alternatives in the Policy-making Process in West Java, Indonesia Priscilla Magrath
Part IV. The Rise of Evidence and Its Uses
Chapter 9. Making Space for Qualitative Evidence in Global Maternal and Child Health Policy-making Christopher J. Colvin
Chapter 10. The International Childbirth Initiative: An Applied Anthropologist's Account of Developing Global Guidelines Robbie Davis-Floyd
Chapter 11. Selling Beautiful Births: The Use of Evidence by Brazil's Humanised Birth Movement Lucy C. Irvine.

Summary: All humans share certain components of tooth structure, but show variation in size and morphology around this shared pattern. This book presents a worldwide synthesis of the global variation in tooth morphology in recent populations. Research has advanced on many fronts since the publication of the first edition, which has become a seminal work on the subject. This revised and updated edition introduces new ideas in dental genetics and ontogeny and summarizes major historical problems addressed by dental morphology. The detailed descriptions of 29 dental variables are fully updated with current data and include details of a new web-based application for using crown and root morphology to evaluate ancestry in forensic cases. A new chapter describes what constitutes a modern human dentition in the context of the hominin fossil record

Contents:
Dental anthropology and morphology
Description and classification of permanent crown and root traits
Biological considerations : ontogeny, asymmetry, sex dimorphism, and inter-trait association
Genetics of morphological trait expression
Geographic variation in tooth crown and root morphology
Establishing method and theory for using dental morphology in reconstructions of human population history
Dental morphology and population history
Fossil hominin dental morphology with a focus on Homo sapiens

Contents:
Human ageing, a biological view / Henrique de Almeida and Liliana Matos
To eat or not to eat : anti-ageing effects of energy restriction / Delminda Neves, Maria Joao Martins, Emanuel dos Passos and Ines Tomada
Nutrition, epigenetics and ageing / Jill McKay and Luisa A. Wakeling
Nutritional intervention in age-related genetic and epigenetic instability and cancer / Thomas Ong and Ana Paula de Melo Loureiro
Nutraceuticals in immunosenescence / Thea Magrone and Emilio Jirillo
Cardiovascular ageing / Carmen Bras Silva and Delminda Neves
Bone and muscle ageing / Joana Carvalho, Elisa Marques and Pedro Moreira
Nutrition and the ageing eye / Angela Carneiro
Nutrition modulation of skin ageing / Alessandra Marini and Jean Krutmann
Retarding brain ageing and cognitive decline / Jose Paulo Andrade
Science-based anti-ageing nutritional recommendations / Ines Tomada and Jose Paulo Andrade.

Summary: The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

Contents:
Retinal Vascular Development
Retinopathy of Prematurity
Anti-Vascular Endothelial Growth Factor (VEGF) Treatment in Neovascular Age-Related Macular Degeneration: Outcomes and Outcome Predictors
AREDS Supplementation and the Progression Towards Neovascular Exudative AMD
VEGF-Inhibition in Macular Telangiectasia Type 2
Diabetic Retinopathy
Retinal Vein Occlusion
Pharmacokinetics of Intravitreally Applied VEGF Inhibitors
Neovascular Glaucoma
Corneal Neovascular Diseases
Anti-Angiogenic Gene Therapy
Basic Science and Challenges for Translation into the Clinic.

Contents:
Curcumin and its role in chronic diseases / A. Kunwar, K. I. Priyadarsini
Berberine and its role in chronic disease / Arrigo F. G. Cicero, Alessandra Baggioni
Emodin and its role in chronic diseases / B. Anu Monisha, Niraj Kumar, Ashu Bhan Tiku
Ursolic acid and chronic disease: an overview of UA's effects on prevention and treatment of obesity and cancer / Anna M. Mancha-Ramirez, Thomas J. Slaga
Tocotrienol and its role in chronic diseases / Kok-Yong Chin, Kok-Lun Pang, Ima-Nirwana Soelaiman
Indole-3-carbinol and its role in chronic diseases / Barbara Licznerska, Wanda Baer-Dubowska
Sanguinarine and its role in chronic diseases / Pritha Basu, Gopinatha Suresh Kumar
Piperine and its role in chronic diseases / Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
Therapeutic potential and molecular targets of piceatannol in chronic diseases / Young-Joon Surh, Hye-Kyung Na
Fisetin and its role in chronic diseases / Harish C. Pal, Ross L. Pearlman, Farrukh Afaq
Honokiol, an active compound of magnolia plant, inhibits growth, and progression of cancers of different organs / Ram Prasad, Santosh K. Katiyar
Celastrol and its role in controlling chronic diseases / Shivaprasad H. Venkatesha, Kamal D. Moudgil
Boswellic acids and their role in chronic inflammatory diseases / H. P. T. Ammon
Natural withanolides in the treatment of chronic diseases / Peter T. White, Chitra Subramanian, Hashim F. Motiwala, Mark S. Cohen
Gambogic acid and its role in chronic diseases / Manoj K. Pandey, Deepkamal Karelia, Shantu G. Amin
Embelin and its role in chronic diseases / Hong Lu, Jun Wang, Youxue Wang, Liang Qiao, Yongning Zhou
Butein and its role in chronic diseases / Ziwei Song, Muthu K. Shanmugam, Hanry Yu, Gautam Sethi
Garcinol and its role in chronic diseases / Amit K. Behera, Mahadeva M. Swamy, Nagashayana Natesh, Tapas K. Kundu
Morin and its role in chronic diseases / Krishnendu Sinha, Jyotirmoy Ghosh, Parames C. Sil
Ellagic acid and its role in chronic diseases / Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar.

Summary: This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer's series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

Summary: This book is a high-quality, innovative resource that examines the cross-cultural, psychiatric interaction between anti-Seminitism and clinical mental health, thereby filling the gap in the psychiatry literature on this particular stigma. Written by experts in this area with a variety of cultural and religious backgrounds, the text focuses on what psychiatrists need to know to combat the negative mental health impact that increasingly rise out of this particular phenomenon. This approach has never been taken in a clinical text. The book begins by introducing the history of the problem before examining the intra- and interpersonal, psycho-, and social aspects of anti-Semitism in psychiatry. Chapters cover the key indicators for recognition, treatment of patients who struggle with the stigma, shock, and trauma created by hate toward this community, as well as tactics for prevention and intervention. Anti-Semitism and Psychiatry is the only non-political, clinical resource on this particular stigma and its negative impact on mental health for psychiatrists, psychologists, primary care physicians, pediatricians, geriatricians, hospital administrators, public health officials, counselors, social workers, and all others.

Contents:
A Short History of the Jewish People
A Short History of Anti-Semitism
Prejudice: Intra and Interpersonal Aspects
Biological Determinants of Bigotry and Its Role in the Resurgence of Severe Anti-Semitism
An Artistic View of Anti-Semitism
Anti-Semitism and the Jewish Identity
A Personal Psychiatric History of Anti-Semitism
Anti-Semitism: Social, Religious, and Clinical Considerations from a Jewish Psychiatrist
Anti-Semitism: Social, Religious, and Clinical Considerations from a Christian Psychiatrist
Anti-Semitism: Social, Religious, and Clinical Considerations from a Muslim Psychiatrist
Anti-Semitism: Social, Religious, and Clinical Considerations from a Hindu Psychiatrist
The Psychological Effects of Anti-Semitism on the Perpetrators and Victims
Anti-Semitism: The Jungian Approach
Anti-Semitism: The Psychoanalytic Approach
Jewish Stereotypes in Diagnosis and Treatment
The Treatment of Anti-Semitic Patients
Anti-Semitism, the Holocaust, and Intergenerational Transmission of Trauma
Community Resilience and the Tree of Life Shootings
Judaism and Rural Psychiatry
Anti-Semitism and Anti-Zionism in the Middle East
A Psychiatric Approach to the Prevention and Treatment of Hate Crimes
Harnessing the Power of Film to Challenge Anti-Semitism
The Role of Jewish Agencies in Reducing Anti-Semitism
Leadership for Reducing Anti-Semitism
Can Anti-Semitism be Cured?.

Contents:
Antiangiogenesis in cancer therapy / Bristi Basu, Swethajit Biswas & Simon Pacey
Mechanism of action of approved antiangiogenesis agents : overview for clinicians / Sarah J. Welsh, Tobias Janowitz & Pippa Corrie
Imaging angiogenesis : role in measuring response to treatment / James P.B. O'Connor
Antiangiogensis : focus on renal cancer / Sarah J. Welsh, Tobias Janowitz & Tim Eisen
Antiangiogenesis : focus on colorectal cancer / Sarah Briggs & Rachel Midgley
Angiogenesis inhibitors and vascular disrupting agents for non-small-cell lung cancer / Adam McGeoch
Antiangiogenesis in cancer therapy : focus on ovarian cancer / Muhammad Adnan Khattak, Hilary Laura Martin & Susana Banerjee
Angiogenesis inhibitors in brain cancer treatment / Soma Sengupta & David A Reardon
Ask the experts : learning from failures and successes, and identifying patients that may benefit from antiangiogenesis therapy / Bristi Basu, Swethajit Biswas & Simon Pacey
Multiple choice questions : answers.

Summary: This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.

Contents:
Introduction: Cardiac arrhythmias a clinical problem
Electrophysiological basis of the arrhythmias
Class I antiarrhythmic drugs (Na+ channel blockers)
Potassium-channel blockers
Betablockers
Modulation of calcium handling/Calcium-channel modulators
Other antiarrhythmic drugs: Novel targets for AADs
Non-antiarrhythmic drugs with antiarrhythmic effects
Clinical management of the arrhythmias.

Summary: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Contents:
Antibacterial drug discovery: perspective insights
Section A: The Challenge of Antibiotic Resistance and Tolerance
Problematic Groups of Multidrug Resistant Bacteria and their Resistance Mechanisms
Emergence and spread of multi-drug resistance in ocular bacterial pathogens: A current update
Antibiotic resistance in Campylobacter jejuni: mechanism, status and public health significance
Mechanisms of biofilm development, antibiotic resistance & tolerance and their role in persistent infections
Developing in vivo infection models with MDR pathogens for evaluating compound efficacy
Section B. New antibiotic drug discovery approaches and progress
Endophytes: a hidden treasure of novel antimicrobial metabolites
Alternative therapies to antibiotics to combat drug-resistant bacterial pathogens
In silico molecular modeling: key technologies in the drug discovery process to combat multidrug resistance
Computational approaches for antibacterial drug discovery
Efflux pump inhibitors and their role in the reversal of drug resistance
Medicinal plants as a reservoir of new structures for anti-infective compounds
Essential oils: Potential application in disease management
Exploration of soil resistome through a metagenomic approach
Actinomycetes as a continued source of new antibacterial leads
Are Ancient Remedies the New Answer to Fighting Infections?
Section C. Alternative antibiotic resistance treatment strategies
Pre and probiotics: Using functional foods in the fight against microbial resistance to antibiotics
Combination of drugs: an effective approach for enhancing the efficacy of antibiotics to combat drug resistance
Targeted delivery of antibiotics using microparticles to combat multi-drug-resistant tuberculosis
Practical applications of bacteriophage therapy: biofilms to bedside
Inhibition of Quorum sensing; prospects in disease control
Approaches for disrupting tissue-associated biofilms
Nanomedic ine and nanoemulsion in increasing the availability of antibiotics
Nanoparticles as new emerging antibacterials: potential and limitation
Nanomaterials as a novel class of anti-infective agents that attenuate bacterial quorum sensing
Nanoparticle-based drug delivery systems: promising approaches against bacterial infections
Green synthesis of metal nanoparticles: characterization and their antibacterial efficacy.

Summary: This book is an up-to-date practical guide to the treatment of both common and unusual bacterial, fungal, and protozoal skin infections. Antibiotics and other treatment options for common skin diseases such as acne, rosacea, erysipelas, and impetigo are extensively discussed, and a thorough update is provided on therapies for fungal infections in the nails, hair, and skin. Current treatments for skin symptoms associated with sexually transmitted diseases are also explored in detail. As the sulfonamides and tetracyclines have long held a special status in dermatology and venereology, an individual chapter focuses on these drugs and their potential side-effects. A range of mycobacterial infections are discussed, and a further chapter considers the treatment of protozoal infections, including leishmaniasis, which are often unfamiliar to practitioners in the Western world. This handy book, with its helpful graphics and clear lists of symptoms, treatments, and practical tips, will be an ideal quick reference for the busy practitioner.

Contents:
Fungal Infections in Skin
Fungal Infections in Hair
Fungal Infections in Nails
Antibiotics in the Management of Acne
Rosacea
Venereal Diseases I: (Chlamydia, Gonorrhea, Syphilis)
Venereal Diseases II: (Chlamydia, Gonorrhea, Syphilis)
Common Bacterial Skin Infections (Erysipelas, Impetigo...)
Tuberculosis, Leprosy, Buruli Ulcer and "Atypical" Mycobacteria
Treatment of Protozoan Parasites of the Skin (Leishmaniasis)
The Use of Sulfonamides, Dapsone and Tetracyclines in Dermatology.

Summary: "Popular as a classroom text, for review, and as a clinical quick-reference, this time-saving resource helps medical students master the rationale behind antibiotic selection for common bacterial pathogens and infectious diseases. Updated content reflects the latest antibiotic medications available on the market, and new full-color illustrations strengthen users' understanding of the application of antibiotic drug treatment.New full-color illustrations reinforce comprehension with greater clarity. Updated content familiarizes users with the most relevant antibacterial agents and treatment guidelines. Succinct, practical guidelines simplify challenging content for easier understanding. Additional pearls emphasize mnemonics and enhance retention of critical information. Remember boxes, History boxes, and drug tables save time with fast access to key information for selecting anti-infection agents. Extensive review cases and questions reinforce learning and clinical application."-- Provided by publisher.

Contents:
Part I:
Bacterial basics
Part II:
Antibacterial agents
Part III:
Definitive therapy
Part IV:
Empiric therapy
Part V:
Clinical cases
Part VI:
Review questions and answers.

Contents:
Antimicrobial Stewardship: Hospital Strategies to Curb Antibiotic Resistance / L. Hsieh and A. Amin
Mechanisms of Antibacterial Resistance: Shedding Some Light on These Obscure Processes? / K. de Sousa Oliveira, L.A. de Lima, N.B. Cobacho, S.C. Dias and O.L. Franco
Signaling Pathways Sustaining Antibiotic Resistance: Lessons From Methicillin-Resistant Staphylococcus auareus / P.F. Seke Etet, A.H. Nwabo Kamdje, L. Vecchio, M. Farahna, and M.F. Mahomoodally
Trends in Antimicrobial Resistance Among Enteric Pathogens: a Global Concern / M. Ballal
Carbapenem-Resistant, Gram-Negative Bacilli: The State of the Art / D.H.Halat, D.K. Sarkis and C.A. Moubareck
Antibiotic Resistance: Can Nanoparticles Tackle the Problem? / M. Rai, K. Kon, A. Gade, A. Ingle, D. Nagaonkar, P. Paralikar and S.S. da Silva
Nanoarchitectonics Used in Antiinfective Therapy / V. Grumezescu, A.M. Holban, I. Barbu, R.C. Popescu, A.E. Oprea, V. Lazar, A.M. Grumezescu and M.C.Chifiriuc
Nanobiocomposites of Metals as Antimicrobial Agents / I.A. Shurygina, M.G. Shurygin and B.G. Sukhov
Can Nitric Oxide Overcome Bacterial Resistance to Antibiotics? / A.B. Seabra, M.T. Pelegrino and P.S. Haddad
Controlling Bacterial Antibiotic Resistance Using Plant-Derived Antimicrobials / A. Upadhyay, D.P. Karumathil, I. Upadhyaya, V. Bhattaram and K. Venkitanarayanan
Essential Oils: A Natural Alternative to Combat Antibiotics Resistance / M.L. Chávez-González, R. Rodríguez-Herrera and C.N. Aguilar
Sensitivity of ESBL-Producing Gram-Negative Bacteria to Essential Oils, Plant Extracts, and Their Isolated Compounds / Gy. Horváth, T. Bencsik, K. Ács and B. Kocsis
Antimicrobial and Antibiotic Potentiating Activity of Essential Oils From Tropical Medicinal Herbs and Spices / Z. Aumeeruddy-Elalfi, A. Gurib-Fakim and M.F. Mahomoodally
Antimicrobial Natural Products Against Bacterial Biofilms / V.G. Beoletto, M. de las Mercedes Oliva, J.M. Marioli, M.E. Carezzano and M.S. Demo
The Potential Use of Bacteriophage Therapy as a Treatment Option in a Post-antibiotic Era / R.R. Bragg, C.E. Boucher, W.A. van der Westhuizen, J.-Y. Lee, E. Coetsee, C. Theron and L. Meyburgh
Bacteriocins and Its Use for Multidrug-Resistant Bacteria Control / G.M. Preciado, M.M. Michel, S.L. Villarreal-Morales, A.C. Flores-Gallegos, J. Aguirre-Joya, J. Morlett-Chávez, C.N. Aguilar and R. Rodríguez-Herrera
Marine Natural Products in Fighting Microbial Infections / G.D. Mogoşanu, A.M. Grumezescu, L.E. Bejenaru and C. Bejenaru
Algae as a Novel Source of Antimicrobial Compounds: Current and Future Perspectives / A. Parsaeimehr and G.A. Lutzu.

Summary: This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.

Contents:
Module 1_Emergence of antibiotic resistant bacteria
Module 2_Impact of antibiotic resistant bacteria on different field
Module 3_Antibiotic resistance: Pattern and Mechanisms
Module 4_Novel strategies for overcoming of antibiotic resistant mechanisms
Module 5_Future Prospects.

Contents:

v. 1. [Beta]-lactam antibiotics.

Contents:
The breakpoint / Matthew A. Wikler, Franklin R. Cockerill III, and Paul G. Ambrose
Antimicrobial susceptibility on solid media / John D. Turnidge and Jan M. Bell
Susceptibility testing of antimicrobials in liquid media / Daniel Amsterdam
Antimicrobial susceptibility testing of anaerobic bacteria / Anilrudh A. Venugopal and David W. Hecht
Antimycobacterial agents : in vitro susceptibility testing and mechanisms of action and resistance / Clark B. Inderlied and Edward Desmond
Antifungal drugs : mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biologic fluids / George R. Thompson III and Thomas F. Patterson
Antimicrobial susceptibility testing for some atypical microorganisms (Chlamydia, Mycoplasma, Rickettsia, Ehrlichia, Coxiella, and Spirochetes) / Jean-Marc Rolain
Applications, significance of, and methods for the measurement of antimicrobial concentrations in human body fluids / Shelly Latte, Emilia Mia Sordillo, and Stephen C. Edberg
Molecular methods for the detection of antibacterial resistance genes : rationale and application / Kristin Hegstad, Törjan Samuelsen, Joachim Hegstad, and Arnfinn Sundsfjord
Molecular mechanisms of action for antimicrobial agents : general principles and mechanisms for selected classes of antibiotics / Charles William Stratton
Antiviral agents for HIV, hepatitis, cytomegalovirus, and influenza : susceptibility testing methods, modes of action, and resistance / Daniel Amsterdam
Disinfectants and antiseptics : modes of action, mechanisms of resistance, and testing regimens / Daniel Amsterdam and Barbara E. Ostrov
Evaluation of antimicrobials in experimental animal infections / D.A. Andes, Alexander J. Lepak, Niels Frimodt-Möller
Extravascular antimicrobial distribution and the respective blood and urine concentrations in humans / David M. Bamberger, John W. Foxworth, Michael Alan Kallenberger, Brian S. Pepito, and Dale N. Gerding
Appendix : antiinfective resistance resource guide / Daniel Amsterdam.

Summary: A comprehensive compendium of all commonly used antibiotics, including indications, side effects, dosage information, and drug/food interactions Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a unique, user-friendly guide made for all who prescribe antibiotics. It's the only book available that takes a 100% drug-listed approach to 200 of the most common antibiotics prescribed to patients each day. Presented in full color, it's also a convenient reference for every clinician to consult once the decision to use a particular antibiotic has been reached. This edition of Antibiotics Manual includes newer antibiotics that have been released since the publication of the First Edition and updates prescribing information for the older antibiotics. This all-new Second Edition: -Has a color-coded interior design which provides quick and easy point of care access for the user -Includes 200 of the most commonly prescribed antibiotics, listed by both brand and generic names -Features important recently-released antibiotics such as ceftaroline, tedizolid, and bedaquiline Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a welcome book for physicians in all specialties of medicine who prescribe antibiotics. It is also a handy tool for pharmacists, nurses, nurse practitioners, and physician assistants who want more information on the drugs they administer.

Contents:
Part 1. Considerations with antibiotic therapy
Part 2. Antibacterial drugs
Part 3. Antimycobacterial drugs
Part 4. Antifungal drugs
Part 5. Antiviral drugs
Part 6. Antiparasitic Drugs
Appendix 1. Selected normal human flora
Appendix 2. Spectrum of activity
Appendix 3. Empiric regimens for common infections
Index.

Contents:
Typical antibody-drug conjugates / John Lambert
Selecting optimal ADC targets using indication-dependent or indication-independent approaches / Robert Hollingsworth and Jay Harper
Antibody drug conjugates : an overview of the CMC and characterization process / Janet Wolfe and Phillip Ross
Linker and conjugation technology and improvements / Riley Ennis and Sourav Sinha
Formulation and stability / Kouhei Tsumoto, Anthony Young, and Satoshi Ohtake
QC assay development / Xiao-Hong Chen and Mate Tolnay
Occupational health and safety aspects of ADCs and their toxic payloads / Robert Sussman and John Farris
Bioanalytical strategies enabling successful ADC translation / Xiaogang Han, Lindsay King, and Steve Hansel
Nonclinical pharmacology and mechanistic modeling of antibody drug conjugates in support of human clinical trials / Brian J. Schmidt, Chin Pan, Heather E. Vezina, Huadong Sun, Douglas D. Leipold, and Manish Gupta
Pharmacokinetics of antibody-drug conjugates / Amrita Kamath
Path to market approval : regulatory perspective of ADC nonclinical safety assessments / Stacey Ricci and Natalie Simpson
Antibody drug conjugates : clinical strategies and applications / Heather E. Vezina, Lucy Lee, Brian J. Schmidt, Manish Gupta
Antibody-drug conjugates (ADCs) in clinical development / Patricia LoRusso and Joseph McLaughlin
ADCs approved for use : Trastuzumab emtansine (Kadcyla, T-DM1) in patients with previously treated HER2-positive metastatic breast cancer / Gail Lewis Phillips, Sanne de Hass, Sandhya Girish, and Ellie Guardino
ADCs approved for use : Brentuximab Vedotin / Sven DeVos and Monica Mead
Radioimmunotherapy / Jeffrey Wong and Savita Dandapani
Radiolabeled antibody-based imaging in clinical oncology / Bart Hendriks and Daniel Gaddy
Antibody-drug conjugates : the next evolution in the cure for cancer
William C. Olson and Amy Q. Han.

Summary: This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

Contents:
1 Antibody-Drug Conjugates: A Historical Review
2 Payloads of Antibody-Drug Conjugates
3 Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy
4 Linker Design for Antibody-Drug Conjugates
5 Formulation Development for Antibody-Drug Conjugates
6 Bioanalytical Assay for Characterization of Antibody Drug Conjugates
7 Pharmacokinetics/Pharmacodynamics and Disposition of Antibody-Drug Conjugates
8 Regulatory Considerations
9 Major ADC Companies, Current Clinical Trials, Recent Patents Issued and Patent Applications, and Cost Analysis of Drug Therapy
10 Mylotarg: Revisiting its Clinical Potential Post-Withdrawal
11 ADCETRIS: A Regulatory Case Study of a New Generation Antibody Drug Conjugate
12 Ado-Trastuzumab Emtansine
13 The Antibody-Drug Conjugate Glembatumumab Vedotin (CDX-011) and its Use in Treatment of Breast Cancer
14 Summary and Future Directions.

Summary: "This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as "Anticancer Genes", are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells."--Publisher's website.

Contents:
1. Introduction / Stefan Grimm
Part I. Viral Anticancer Genes
2. Signalling of Apoptin / Jessica Bullenkamp and Mahvash Tavassoli
3. Apoptin Towards Safe and Efficient Anticancer Therapies / Claude Backendorf and Mathieu H.M. Noteborn
4. Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Protein / Tamar Kleinberger
5. Tumor Suppressing Properties of Rodent Parvovirus NS1 Proteins and Their Derivatives / Jürg P.F. Nüesch and Jean Rommelaere
Part II. Cellular Anticancer Genes
6. MDA-7/IL-24: Multifunctional Cancer Killing Cytokine / Mitchell E. Menezes, Shilpa Bhatia, Praveen Bhoopathi, Swadesh K. Das, Luni Emdad, Santanu Dasgupta, Paul Dent, Xiang-Yang Wang, Devanand Sarkar, and Paul B. Fisher
7. Cancer-Selective Apoptosis by Tumor Suppressor Par-4 / Nikhil Hebbar, Tripti Shrestha-Bhattarai, and Vivek M. Rangnekar
8. Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) / Simone Fulda
9. SIRT6: A Promising Target for Cancer Prevention and Therapy / Michael Van Meter, Vera Gorbunova, and Andrei Seluanov
10. An Overview of Brevinin Superfamily: Structure, Function and Clinical Perspectives / Anna Savelyeva, Saeid Ghavami, Padideh Davoodpour, Ahmad Asoodeh, and Marek J. Łos
11. Isolation and Characterization of the Anticancer Gene Organic Cation Transporter Like-3 (ORCTL3) / Ghada AbuAli and Stefan Grimm
Part III. Anticancer Gene Therapy
12. Introduction of Genes via Sonoporation and Electroporation / Christina Kalli, Wey Chyi Teoh, and Edward Leen
13. Anticancer Gene Transfer for Cancer Gene Therapy / Evangelos Pazarentzos and Nicholas D. Mazarakis.

Summary: This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. Thebook provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research.

Contents:
Chapter 1. Omics- a holistic approach in cancer treatment
Chapter 2. Plant miRNAs and phytomolecules as anticancer therapeutics
Chapter 3. Potential of herbal medicines in colorectal carcinoma and their mechanism of action
Chapter 4. Elucidation of mechanisms of anticancer plant compounds against the tumor cells
Chapter 5. Computational approach towards exploring interaction of target protein-phytocompounds in drug development for breast cancer
Chapter 6. Anticancer Potential of Andrographolide, a diterpenoid lactone from Andrographis paniculata: A nature's treasure for chemoprevention and therapeutics
Chapter 7. Anticancer activity of herbal medicine: Mechanism of action
Chapter 8. Metabolomic study of chemo-preventive phytochemicals and their therapeutic prospects
Chapter 9. CADD studies applied to secondary metabolites in the anticancer drug research
Chapter 10. Anticancerous plant compounds affecting the power house of cancerous cells: A possible herbal mitocan
Chapter 11. Phytoestrogens as a natural source for the possible colon cancer treatment
Chapter 12. Bioinformatics approaches for genomics and post genomics applications of anticancer plants
Chapter 13. Fruits of Rosaceae family as a source of anticancer compounds and molecular innovations
Chapter 14. Mechanism of action of anticancer herbal medicines.

Summary: This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements - Volume 2 explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Contents:
Chapter 1. Fungal Endophytes as Novel Sources of Anticancer Compounds
Chapter 2. Gastrointestinal Bezoar Stones: Current Knowledge and Future Pperspective on the Potential of Plant-derived Phytobezoar in Cancer Treatment
Chapter 3. Potential of Natural Products for Prevention of Oral Cancer
Chapter 4. Therapeutic Potential of Cardiac Glycosides Against Cancer
Chapter 5. Conserving Biodiversity of a Potent Anticancer Plant, Catharanthus roseus Through In vitro Biotechnological Intercessions: Substantial Progress and Imminent Prospects
Chapter 6. Medicinal Plants as a Potential Source of Chemopreventive Agents
Chapter 7. Plant Metabolites as New Leads to Anticancer Drug Discovery: Approaches and Challenges
Chapter 8. Terpenes of Genus Salvia: Cytotoxicity and Antitumoral Effects
Chapter 9. Essential Oil with Anticancer Activity: An Overview
Chapter 10. Fungal Endophytes from Anticancer Plants as Producers of the Anti-tumour Agent L-Asparaginase: A Look at Diversity, Ubiquity and Enzyme Production
Chapter 11. Xylooligosaccharides and their Anticancer Potential: An Update
Chapter 12. Phytochemicals Targeting Endoplasmic Reticulum Stress to Inhibit Cancer Cell Proliferation
Chapter 13. Remedy of Targeting Cancer and Cancer Stem Cells with Botanicals
Chapter 14. Therapeutic Strategies of Natural Agents and its Components on Triple-Negative Breast Cancer
Chapter 15. Endophytic Microbes as a Novel Source for Producing Anticancer Compounds as Multidrug Resistance Modulators. Chapter 16. Traditional Medicinal Plants and their Therapeutic Potential Against Major Cancer Types
Chapter 17. Platelet Derived Growth Factor Receptor (PDGF-R) as the Target for Herbal Based Anticancer Agents
Chapter 18. Plant Cell and Organ Culture as an Alternative for the Production of Anticancer Compounds
Chapter 19. Plant Derived Extracts and Compounds: An Alternative Therapy Against Breast Cancer
Chapter 20. Micropropagation and Conservation of Selected Endangered Anticancer Medicinal Plants from the Western Ghats of India
Chapter 21. Biotechnological Approaches for the Propagation of Anticancer Plants and the Production of Vital Compounds
Chapter 22. An Alternative Approach for Anticancer Compounds Production Through Plant Tissue Culture Techniques
Chapter 23. Biotechnological Intervention Through Tissue Culture in Hedychium coronarium: A Potential Anticancer Plant.

Summary: Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.

Contents:
Current practices and awareness of anticancer plants in the traditional healthcare system
Phytochemical and biological properties of Lippia gracilis
Use of Indian indigenous fruits in cancer prevention and treatment
Potentiality of anticancer plant derived compounds of North-East India
Plant-derived compounds in cancer therapy: Traditions of past and drugs of future
Anticancer plant molecules for Improvement of immune system
Fermented food derived bioactives compounds with anti-carcinogenic properties: Fermented Royal jelly as a novel source for compounds with health benefits
Mass spectrometry based techniques for assessment of pharmacological responses of ayurvedic drugs
Assessment of anticancer properties of betelvine
Analysis of patents filed for the herbal therapeutics against cancer
Appraisal of medicinal plants with anticancer properties in South America
Scientific validation of the usefulness of Withania somnifera Dunal in the prevention and treatment of cancer
Anticancer potential of mangrove plants: Neglected plant species of the marine ecosystem
Piper betel Linn. in cancer: Past, Present and Future
Anticancer properties of curcumin and its efficacy for treating central nervous system neoplasms
Vitamin E: The Nature's Gift to Fight Cancer
Use of plant secondary metabolites as nutraceuticals for treatment and management of cancer: Approaches and challenges
Usefulness of Ocimum sanctum Linn. in cancer prevention: An Update
Phytochemicals with anticancer potential: Methods of extraction, basic structure and chemotherapeutic action
Anticancer plants and their conservation strategies
Anticancer plants: Chemistry, pharmacology and potential applications
Botany, chemistry and pharmaceutical significance of Sida cordifolia- A Traditional medicinal plant
Anticancer properties of natural compounds on prostate cancer
Phytochemicals against cancer stem cells.

Contents:
Part 1. General Principles
Physiology of Hemostasis
Laboratory Assessment of Physiologic and Pathologic Hemostasis
Current Anticoagulation Drugs and Mechanisms of Action
Reversal of Target-Specific Oral Anticoagulants
Overview, Treatment, Measurement, and Modification of Platelet Function
Role of Antiplatelet Therapy in Neurosurgery: Efficacy and Safety Profiles
Part 2. Coagulation Issues Across all Patient Spectrums
Congenital Coagulation Disorders
Acquired Coagulation Disorders
Regulation and Dysregulation of Fibrinolysis
Risks Associated with Administration of Allogeneic Blood Components
Common Coagulation Disorders That May Arise Intraoperatively
Evaluation and Management of Untoward Intraoperative Bleeding
Treatment of Disseminated Intravascular Coagulation (DIC)
Heparin-Induced Thrombocytopenia (HIT)
Anticoagulation in Cardiovascular Diseases
Workup and Treatment of Pulmonary Embolus
Part 3. Coagulation Issues Specific to Neurosurgery
Classes of Drugs and Blood Products for Acute Reversal of Anticoagulant Effect
Rescue Strategies to Facilitate Emergency Neurosurgery in Patients on Antiplatelet or Anticoagulant Agents
Considerations for Coagulation in the Multi-Trauma Patient
Cerebral Venous Sinus Thrombosis
Coagulation Studies in Preoperative Neurosurgery Patients
Safe Strategies for Gradual Suspension and Re-institution of Anticoagulation to Permit Elective Surgery
Spontaneous Intracerebral Hemorrhage due to Coagulation Disorders
Prophylactic Screening for Venous Thromboembolism in Neurosurgical Patients
Venous Thromboembolism Prophylaxis in Neurosurgery
Can Patients with Known Intracranial and Intraspinal Vascular Lesions be Anticoagulated?
Intrathecal Access and Devices in Patients on Antiplatelet or Anticoagulant Therapy
Is it Safe to Shunt Anti-coagulated NPH Patients?
Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary.

Summary: This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.

Summary: This volume reviews the known neurobiology of depression and combines classic data on antidepressant treatments with modern theory on the physiology of depression. It also discusses novel mechanism of action drugs.

Contents:
Intro; Preface; Contents; Impact, Diagnosis, Phenomenology, and Biology; 1
Section 1: Prevalence; 2 Impact; 2.1 Disability and Economic Impact; 2.2 Suicide; 3 Diagnosis; 3.1 History; 3.2 Operational Definitions; 3.3 Subtypes; 4 Measurement; 4.1 Self-Rated Scales; 4.2 Clinician-Rated Scales; 5 Phenomenology; 6 Diagnostic Boundaries; 7 Biology; References; Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look?; 1 Historical Background 2 Studies Comparing MAOI and TCA Antidepressants: Do Certain Subtypes of Depression Respond Selectively to One Class of Antide ... 3 More Recent Studies of Tricyclic Antidepressants and Monoamine Oxidase Inhibitors; 4 The Under-Prescribing of Monoamine Oxidase Inhibitors and Tricyclic Antidepressants: A Justifiable Phenomenon?; References; Clinical Implications of the STAR*D Trial; 1 Introduction and Overview of STAR*D; 1.1 Participants; 1.2 Treatment Outcomes; 1.3 Treatment Steps; 1.4 Treatment Delivery; 1.5 Continuation Phase Treatment; 2 Who Is Being Treated for Depression in Practice? 2.1 How Comparable Are Depressed Patients in Primary and Psychiatric Care Settings?2.2 Are FDA Registration Trial Participants Representative of Depressed Patients Treated in Practice?; 2.3 Clinical Implications; 3 Treatment Outcomes with the Initial Medication Treatment Step with a Selective Serotonin Reuptake Inhibitor (SSRI); 3.1 When and How Often Does Response and Remission Occur with an SSRI; 3.2 Can Baseline Features Tell Us Who Will Respond or Remit with the Initial SSRI?; 3.3 What Are the Long-Term Outcomes Following a Successful First-Step SSRI? 3.4 Does the Prior Course of MDD Predict Acute or Longer-Term Treatment Outcomes with Citalopram?3.5 Clinical Implications; 4 Treatment Outcomes with the Second Medication Treatment Step; 4.1 Which Second-Step Treatment Options Are Preferred by Which Patients?; 4.2 When the Initial SSRI Fails and a Medication Switch Is Provided, Do Pharmacological Differences Matter?; 4.3 Which Augmentation Strategy Is More Effective, Bupropion-SR or Buspirone?; 4.4 How Did Augmentation with Cognitive Behavior Therapy Compare with Medication Augmentation? 4.5 How Did Switch to Cognitive Therapy Compare with Switch to Medication?; 4.6 Follow-Up After the Second Treatment Step; 4.7 Clinical Implications; 5 Selecting Among Switch Treatments at the Second Medication Treatment Step; 5.1 What Are the Overall and Differential Predictors of Remission (Baseline Sociodemographic, Clinical, and First-Step Treatme ... ; 5.2 What Are the Overall and Differential Predictors (Baseline Sociodemographic, Clinical, and First-Step Treatment Features) ... ; 5.3 Clinical Implications; 6 Treatment Outcomes with the Third Medication Treatment Step

Contents:
1. Introduction
2. Antipileptic drugs and becoming pregnant
3. Antiepileptic drug disposition in pregnancy
4. The older antiepileptic drugs
5. Commonly used newer antiepileptic drugs
6. Antiepileptic drugs sometimes used in pregnancy
7. Antiepileptic drugs, epileptic seizures and the foetus
8. Antiepileptic drugs and foetal malformations: a possible class effect
9. Particular antiepileptic drugs and foetal malformations
10. Antiepileptic drugs, cognition and neurodevelopment
11. Antiepileptic drug therapy: management issues and pregnancy
12. Antiepileptic drugs and pregnancy: the future
Appendix
Index.

Summary: This first volume provides a comprehensive overview on evolutionary, environmental and systematic aspects of antifreeze proteins. It shortly explains the physical properties of ice and further intelligibly describes the biology of the antifreeze proteins in different organisms. It offers a detailed insight into their history of evolution. In addition the book discusses the status of the current knowledge and ongoing research and highlights also those parts, where further investigation needs to be done. Together with the second volume on the biochemistry and molecular biology of antifreeze proteins, this book represents a unique, comprehensive work and a must-have for students and scientists in biochemistry, evolution, physiology and physical chemistry.

Contents:
Introduction
Ice and its formation
Ice formation in living organisms
Fish antifreeze proteins
Insect antifreeze proteins
Plant antifreeze proteins
Antifreeze proteins in other species
Molecular origins and mechanisms of fish antifreeze evolution.

Summary: This second volume, written in four parts, offers the reader a thorough review on molecular, structural and applied aspects of antifreeze proteins. The first part treats the structure-function relationship and the physicochemical properties of antifreeze proteins; the second part provides insight into molecular mechanisms affected by antifreeze proteins; the third part presents some of the potential applications in various professional sectors and in the last part the book content is summarized and future research directions and ideas are discussed. Together with the first volume on the environment, systematic and evolution of antifreeze proteins, this book represents a unique, comprehensive work and a must-have for students and scientists in biochemistry, molecular biology, biotechnology and physical chemistry.

Contents:
Of volume 2 Antifreeze proteins: Biochemistry, molecular biology and applications
Characteristics of antifreeze proteins
Physicochemical properties of antifreeze proteins
Structure-function of IBPs and their interactions with ice
Interaction of antifreeze protein with water
Thermal hysteresis
Inhibition of recrystallization
Other protective measures of antifreeze proteins
Measuring antifreeze protein activity
Antifreeze proteins in foods
Cell, tissue and organ preservation with insect-derived antifreeze peptides
Antifreeze proteins and gas hydrate inhibition
Antifreeze protein-covered surfaces
Mutational studies on antifreeze proteins
Summary and future directions.

Summary: Includes information on antimicrobial therapy and alternative therapy when the drug of choice cannot be given. The resource delivers information via review articles, capsule summaries, mini-reviews, and a guided PubMed search to pick up post-publication research.

Summary: "A valuable resource for undergraduates and graduates providing a thorough grounding in the scientific basis and clinical application of antimicrobial drugs. The new edition has been thoroughly updated to include the most recently licensed agents, including the treatment of HIV and contains guidance on prescribing and infection control practices." -- Provided by publisher.

Contents:
Part 1. General properties of antimicrobial agents. 1. Mechanisms of action and resistance to modern antibacterial with a history of their development ; 2. Inhibitors of bacterial cell wall synthesis ; 3. Inhibitors of bacterial protein synthesis ; 4. Synthetic antibacterial agents and miscellaneous antibiotics ; 5. Antiviral agents ; 6. Antiretroviral agents ; 7. Drugs used in the treatment of viral hepatitis ; 8. Antifungal agents ; 9. Antiprotozoal and anthelminthic agents
Part 2. Resistance to antimicrobial agents. 10. The problem of resistance ; 11. The genetics and mechanisms of acquired resistance
Part 3. General principles of usage of antimicrobial agents. 12. Laboratory investigations and the treatment of infection ; 13. General principles of the treatment of infection ; 14. Pharmacokinetic and pharmacodynamics principles ; 15. Prescribing in special groups : effects of age, pregnancy, body weight, hepatic and renal impairment 16: Outpatient parenteral antimicrobial therapy ; 17. Adverse drug reactions and patient safety ; 18. Chemoprophylaxis and immunisation ; 19. Guidelines, formularies, and antimicrobial policies ; 20. Antimicrobial stewardship, surveillance of antimicrobial consumption and its consequences
Part 4. Therapeutic use of antimicrobial agents. 21. Respiratory tract infections ; 22. Topical use of antimicrobial agents ; 23. Urinary tract infections ; 24. Sexually transmitted infections ; 25. Gastrointestinal infections ; 26. Serious bacterial bloodstream infections ; 27. Bone and joint infections ; 28. Infections of the central nervous system ; 29. Skin and soft tissue infections ; 30. Tuberculosis and other mycobacterial diseases ; 31. Infections in immunocompromised patients including HIV/AIDs ; 32. Viral infections ; 33. Management of HIV infection ; 34. Treatment of chronic viral hepatitis ; 35. Parasitic disease ; 36. The development and marketing of antimicrobial drugs.

Summary: Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Contents:
Strategies for the design and discovery of novel antibiotics using genetic engineering and genome mining
X-ray and Neutron Scattering Foundations for the Research in Antimicrobials
Antibacterial, Antiviral and Antifungal Activity of Essential Oils: Mechanisms and Applications
New antimicrobial agents of plant origin
Advances in beta-lactam antibiotics
The Cornerstone of Nucleic Acid-affecting Antibiotics in Bacteria
Genetic analysis and manipulation of polyene antibiotic gene clusters as a way to produce more effective antifungal compounds
Enzybiotics: The rush towards prevention and control of multi-resistant bacteria (MRB)
New cell wall-affecting antifungal antibiotics
Perspectives in the research on Antimicrobial peptides
Glycopeptides and bacterial cell walls.

Contents:
Antimicrobial peptides in cutaneous wound healing
Antimicrobial peptides as endogenous antibacterials and antivirals at the ocular surface
Function of antimicrobial peptides in lung innate immunity
Role of antimicrobial peptides to prevent infections in the kidney and urinary tract
Antimicrobial peptides in the gut
Metal sequestration: An important contribution of antimicrobial peptides to nutritional immunity
Regulation of antimicrobial peptide gene expression by vitamin D
Dichotomous roles of cationic polypeptides targeting HIV
Antimicrobial peptides in host-defense: functions beyond antimicrobial activity.

Summary: Antimicrobial resistance is a major global public health problem. This book focuses on the clinical implications of multi-drug resistant pathogens; tracking AMR and its evolutionary significance; antifungal resistance; and current and alternative treatment strategies for AMR, including antivirulent, antibiofilm and antimicrobial resistance breakers, repurposing of drugs, and probiotic therapy. Advances in antimicrobial stewardship, antibiotic policies from a global perspective and their impacts are also discussed. The book also explores the use of omics approaches to gain insights into antibacterial resistance, and includes chapters on the potential benefits of a 'One Health approach describing the environmental and zoonotic sources of resistant genes and their effects on the global resistance pool.

Contents:
ntro
Foreword
Preface
Acknowledgments
Contents
About the Editor
The Evolution of Microbial Defence Systems Against Antimicrobial Agents
1 Introduction
2 Bacteria
2.1 The Non-specific Bacterial Defence System
2.1.1 Intrinsic
Outer Membrane of Gram-Negative Bacteria
Porin Channels
Capsular Defences
Bacterial Innate Immunity to Bacteriophages
Defences During Phage Attachment and Entry
Defences During Replication
Defences During Host Cell Lysis
2.1.2 Acquired
Multidrug-Resistant (MDR) Efflux Pumps
Horizontal Gene Transfer; Transformation
Conjugation
2.2 The Specific Bacterial Defence System
2.2.1 Intrinsic Active
Quorum Sensing
Indole
CRISPR/Cas9
Biofilm Formation and Persister Cells
2.2.2 Intrinsic Passive
Horizontal Gene Transfer
Transduction
2.2.3 Acquired Active
Enzymatic Degradation/Destruction
Target Protection by Obstruction/Alteration/Mutation
2.2.4 Acquired Passive
Co-pathogens Conferring Resistance
3 Fungi
3.1 Azoles
3.2 Echinocandins
3.3 Other Mechanisms of Resistance
4 Viruses
4.1 Hepatitis C
4.2 Influenza; 5 Discussion and Therapeutic Strategies for the Future
References
Carbapenem Resistance in Gram-Negative Bacilli: Mechanisms and Challenges
1 Introduction
2 Structure of Carbapenems
3 Mechanism and Epidemiology of Carbapenem Resistance
3.1 Carbapenem-Resistant Enterobacteriaceae (CRE)
3.2 Carbapenemase-Producing CRE (CP-CRE)
3.2.1 Class A Carbapenemases
3.2.2 Class B Carbapenemases
3.2.3 Class D Carbapenemases
4 Noncarbapenemase-Producing CRE (Non-CP-CRE)
4.1 Carbapenem-Resistant Pseudomonas (CRP)
4.2 Carbapenem-Resistant Acinetobacter baumannii (CRAB); 5 Current Resistance Status
6 Antibiotic Resistance Drivers
7 Usage and Side Effects of Carbapenems
8 Laboratory Detection of Carbapenem-Resistant Organism
8.1 Detection of Carbapenemase Activity Directly from the Clinical Specimen
8.1.1 CDC Screening Criteria
8.1.2 Chromogenic Plates
8.2 Detection of Carbapenemase Activity in the Isolated Bacteria
8.2.1 Phenotypic Tests
8.2.2 Molecular Tests
8.2.3 Molecular Test
9 Treatment
10 Role of Infection Control and Antibiotic Stewardship
11 Conclusion
References; Influence of Antimicrobials on the Gut Microbiota
1 Introduction
2 Human Gut Microbiota and Its Ecosystem
3 Role of Gut Microbiota in Human Health
4 Metagenomic Analysis of Gut Microbiota
5 Influence of Antibiotics on Normal Gut Microbiota
6 Human Gut Resistome
7 Infant Gut Microbiota and Antibiotics
8 Therapeutic Interventions of Post-antibiotic Gut Microbiome Reconstitution
9 Conclusion
References
Influence of Abiotic Factors in the Emergence of Antibiotic Resistance
1 Introduction
2 Environmental Factors
2.1 Heavy Metals
2.2 Pesticides.

Summary: This report examines, for the first time, the current status of surveillance and information on antimicrobial resistance (AMR) at country level worldwide, with particularly attention to antibacterial resistance.

Contents:
1. Introduction to antimicrobial-resistant foodborne pathogens / Patrick Butaye, Maria Angeles Argudín and John Threlfall
2. Antimicrobial resistance of Shiga toxin-producing Escherichia coli / Jinru Chen
3. Antibiotic resistance in pathogenic Salmonella / Steven C. Ricke and Juliany Rivera Calo
4. Antimicrobial resistance and Campylobacter jejuni and C. coli / Mirko Rossi, Satu Olkkola, Mati Roasto, Rauni Kivistö and Marja-Liisa-Hänninen
5. Antimicrobial resistance in Yersinia enterocolitica / Anna Fabrega, Clara Ballesté-Delpierre and Jordi Vila
6. Antimicrobial resistance in Vibrio species / Craig Baker-Austin
7. Antimicrobial resistance in Shigella species / Keith A. Lampel
8. Antimicrobial resistance in Listeria spp. / Nathan A. Jarvis, Philip G. Crandall, Corliss A. O'Bryan and Steven C. Ricke
9. Antibiotic resistance in Enterococci : a food safety perspective / Anuradha Ghosh and Ludek Zurek
10. Clostridium difficile: a food safety concern? / Jane W. Marsh and Lee H. Harrison
11. Methods for the detection of antimicrobial resistance and the characterization of Staphylococcus aureus isolates from food-producing animals and food of animal origin / Kristina Kadlec, Sarah Wendlandt, Andrea T. Fessler and Stefan Schwarz
12. Non-phenotypic tests to detect and characterize antibiotic resistance mechanisms in Enterobacteriaceae / Agnese Lupo, Krisztina M. Papp-Wallace, Robert A. Bonomo and Andrea Endimiani
13. Monitoring and surveillance : the national antimicrobial resistance monitoring system / Emily Crarey, Claudine Kabera and Heather Tate
14. Risk assessment of antimicrobial resistance / H. Gregg Claycamp
15. Food microbial safety and animal antibiotics / Louis Anthony (Tony) Cox
16. Antibiotic-resistant bacteria and resistance genes in the water-food nexus of the agricultural environment / Pei-Ying Hong
17. Development and application of novel antimicrobials in food and food processing / Yangjin Jung and Karl R. Matthews
18. Database resources dedicated to antimicrobial peptides / Guangshun Wang
19. Metabolic network analysis-based identification of antimicrobial drug target in pathogenic bacteria / Vinayak Kapatral
20. Application of metagenomic technologies for antimicrobial resistance and food safety research and beyond / Chin-Yi Chen, Xianghe Yan, Siyun Wang and Charlene R. Jackson.

Summary: Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotics is discussed. Some topics are immediately practical, such as watching for resistant pathogen sub-populations in cultures taken from patients; other topics point to future research efforts that may lead to new antimicrobials and ways to stimulate the action of existing ones. Overall, Antimicrobial Resistance in the 21st Century provides an update for physicians, serves as a starting point for graduate students interested in solving the resistance problem, and may serve as a text for a course on resistance. Lay readers familiar with microbiology will gain an appreciation for a medical issue that promises to be one of the most important of our time. Ignatius Fong, Department of Medicine, University of Toronto Series Editor - Emerging Infectious Diseases of the 21st Century David Shlaes, Founder, Anti-Infectives Consulting Editor - Antimicrobial Agents and Chemotherapy Karl Drlica, The Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey.

Contents:
Antimicrobial resistance genes and wastewater treatment / Mehrnoush Mohammadali and Julian Davies
When pathogens and environmental organisms meet : consequences for antibiotic resistance / Jose Luis Martinez and Fernando Baquero
One health : the role wastewater treatment plants play as reservoirs, amplifiers, and transmitters of antibiotic resistance genes and antibiotic resistant bacteria / Marilyn C. Roberts
Assessing the impact of wastewater treatment plants on environmental levels of antibiotic resistance / Jessica Williams-Nguyen, Irene Bueno, and Randall S. Singer
Navigating through the challenges associated with the analysis of antimicrobials and their transformation products in wastewater / Randolph R. Singh, Rachel A Mullen and Diana S. Aga
Metagenomic approaches for antibiotic resistance gene detection in wastewater treatment plants / Ying Yang and Tong Zhang
Antimicrobials and antimicrobial resistant bacteria in Australia / Andrew J. Watkinson and Simon D. Costanzo
The mobile resistome in wastewater treatment facilities and downstream environments / Roberto B.M. Marano and Eddie Cytryn
Bacterial diversity and antibiotic resistance genes in wastewater treatment plant influents and effluents / Veiko Voolaid, Erica Donner, Sotirios Vasileiadis, and Thomas U. Berendonk
The effect of advanced treatment technologies on the removal of antibiotic resistance
Popi karaolia, Stella Michael, and Despo Fatta-Kassinos
Antimicrobial resistance spread mediated by wastewater irrigation: the Mezquital Valley case study / Melanie Broszat and Elisabeth Grohmann
Antimicrobial resistance related to agricultural wastewater and biosolids / Lisa M. Durso and Amy Millmier Schmidt
Environmental antibiotic resistance associated with land application of biosolids / Jean E. Mclain, Channah M. Rock, and Charles P. Gerba
High throughput method for analyzing antibiotic resistance genes in wastewater treatment plants / Johanna Muurinen, Antti Karkman, and Marko Virta
Antibiotic resistance and wastewater treatment process / Thi Thuy Do, Sinéad Murphy, and Fiona Walsh
Antibiotic pollution and occurrence of bacterial antibiotic resistance genes in Latin American developing countries : case study of the Katari watershed in the Bolivian highlands / Denisse Archundia, Celine Duwig, Jean M.F. Martins, Frederic Lehembre, Marie-Christine Morel, and Gabriela Flores
Antimicrobial resistance in hospital wastewaters / Judith Isaac-Renton and Patricia L. Keen
Curbing the resistance movement : examining public perception of the spread of antibiotic resistant organisms / Agnes V. Macdonald and Patricia L. keen
Public health consequences of antimicrobial resistance in the wastewater treatment process / Patricia L. Keen, Raphaël Fugère, and David M. Patrick.

Contents:
Section 1. Setting the scene and starting up
Section 2. Components of an antimicrobial stewardship programme
Section 3. Special areas in antimicrobial stewardship.

Contents:
Section 1: The global picture of antimicrobial use and resistance
Section 2: AMS Strategies
Section 3: AMS in specific clinical settings
Section 4: AMS experience around the world
Section 5: Research and perspectives.

Summary: Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.

Summary: "Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations"-- Provided by publisher.

Summary: This book provides an overview of antioxidants and antioxidant enzymes and their role in the mechanisms of signaling and cellular tolerance under stress in plant systems. Major reactive oxygen species (ROS)-scavenging/modulating enzymes include the superoxide dismutase (SOD) that dismutates O2 into H2O2, which is followed by the coordinated action of a set of enzymes including catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and peroxiredoxins (Prx) that remove H2O2. In addition to the ROS scavenging enzymes, a number of other enzymes are found in various subcellular compartments, which are involved in maintaining such redox homeostasis either by directly scavenging particular ROS and ROS-byproducts or by replenishing antioxidants. In that respect, these enzymes can be also considered antioxidants. Such enzymes include monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR), alternative oxidases (AOXs), peroxidases (PODs) and glutathione S-transferases (GSTs). Some non-enzymatic antioxidants, such as ascorbic acid (vitamin C), carotenes (provitamin A), tocopherols (vitamin E), and glutathione (GSH), work in concert with antioxidant enzymes to sustain an intracellular steady-state level of ROS that promotes plant growth, development, cell cycles and hormone signaling, and reinforces the responses to abiotic and biotic environmental stressors. Offering a unique compilation of information on antioxidants and antioxidant enzymes, this is a valuable resource for advanced students and researchers working on plant biochemistry, physiology, biotechnology, and signaling in cell organelles, and those specializing in plant enzyme technology.

Contents:
Plant superoxide dismutases: Function under abiotic stress conditions
Studies of catalase in plants under abiotic stress
Ascorbate peroxidase functions in higher plants: The control of the balance between oxidative damage and signaling
Glutathione reductase: Safeguarding plant cells against oxidant damage
Function of the various MDAR isoforms in higher plants
Peroxiredoxins: Types, characteristics and functions in higher plants
Redox protein thioredoxins: Function under salinity, drought and extreme temperature conditions
Biosynthesis and regulation of ascorbic acid in plants
Glutathione metabolism and its function in higher plants adapting to stress
Revisiting carotenoids and their role in plant stress responses: From biosynthesis to plant signaling mechanisms during stress. Abiotic stress response in plants
the relevance of tocopherols
Role of flavonoids in plant stress. Class III peroxidases: isoenzymes functions, localization and redox regulation.

Contents:
1. Oxidation in aquatic foods and analysis methods / Magnea G. Karlsdottir, Holly T. Petty, and Hordur G. Kristinsson
2. Protein oxidation in aquatic foods / Caroline P. Baron
3. Influence of processing on lipids and lipid oxidation in aquatic foods / Sivakumar Raghavan and Hordur G. Kristinsson
4. Strategies to minimize lipid oxidation of aquatic food products post harvest / Huynh Nguyen Duy Bao and Toshiaki Ohshima
5. Antioxidative strategies to minimize oxidation in formulated food systems containing fish oils and omega-3 fatty acids / Charlotte Jacobsen, Anna Frisenfeldt Horn, Ann-Dorit Moltke Sorensen, K.H. Sabeena Farvin, and Nina Skall Nielsen
6. Methods for assessing the antioxidative activity of aquatic food compounds / Holmfridur Sveinsdottir, Patricia Y. Hamaguchi, Hilma Eidsdottir Bakken, and Hordur G. Kristinsson --7. Influence of fish consumption and some of its individual constituents on oxidative stress in cells, animals, and humans / Britt Gabrielsson, Niklas Andersson, and Ingrid Undeland
8. Marine antioxidants: polyphenols and carotenoids from algae / Kazuo Miyashita
9. Fish protein hydrolysates: production, bioactivities, and applications / Soottawat Benjakul, Suthasinee Yarnpakdee, Theeraphol Senphan, Sigrun M. Halldorsdottir, and Hordur G. Kristinsson
10. Antioxidant properties of marine macroalgae / Tao Wang, Rosa Jonsdottir, Gudrun Olafsdottir, and Hordur G. Kristinsson.

Summary: This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body's natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.

Contents:
Biochemistry of coenzyme Q10
Coenzyme Q10 in male infertility
Carnitine in male infertility
Free radicals in andrology
Antioxidants in male sexual disorders
Antioxidants in major accessory gland infections.

Summary: This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss or complications are explained. The main clinical manifestations and classification criteria are described and diagnostic tools, identified. Close attention is paid to the nature of the involvement of other organs or organ systems in APS, including the nervous, endocrine, hematologic, cardiovascular, and gastrointestinal systems, the kidney, the skin, and the eye. Specific chapters describe the treatment of the different symptoms, the preventive therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome

Contents:
Foreword
Preface
1 APS: Introductory notes
2 Immunology and Genetics of APS
3 The paradox of the lupus anticoagulant
4 The pathogenic mechanism(s) for APS-mediated thrombosis
5 The pathogenic mechanism(s) for APS-mediated pregnancy loss
6 Classification criteria
7 Non-classification criteria
8 Obstetric APS
9 APS and the nervous system
10 APS and renal involvement
11 Non-thrombotic hematologic manifestations in APS
12 Heart and APS
13 Skin and APS
14 Additional organs involved in APS (eye, ENT, GI, endocrine)
15 Treatment of thrombosis
16 Treatment of pregnancy complications
17 Asymptomatic carries of APS
18 New treatments
19 Secondary APS
20 Catastrophic APS.

Contents:
Part I. Historical aspects of antiphospholipid syndrome
1. History of antiphospholipid antibody
Part II. Basic Science Aspects of Antiphospholipid Syndrome
2. Natural proteins involved in antiphospholipid syndrome
3. Origin of antiphospholipid antibodies
4. Recent advances in understanding of the genetics of antiphospholipid syndrome
5. Mechanisms of antiphospholipid antibody-mediated thrombosis
6. Mechanisms of antiphospholipid antibody-mediated prenancy morbidity
Part III. Clinical and diagnostic aspects of antiphospholipid syndrome
7. Definition and epidemiology of antiphospholipid syndrome
8. Clinical and prognostic significance of non-criteria antiphospholipid antibody tests
9. Disease and risk measurement criteria in antiphospholipid syndrome
10. Neurophyschiatric manifestations of antiphospholipid syndrome
Part IV. Therapeutic aspects of antiphospholipid syndrome
11. Prevention and treatemnt of obstetric antiphospholipid syndrome
13. Treatment of non-criteria manifestations in antiphospholipid syndrome
14. Antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION)
Part V. 15th International Congress on Antiphospholipiid Antibodies Task Force reports
15. 15th International Congress on Antiphospholipid Antibodies Task Force on Antiphospholipid Syndreome Classification Report
16. 15th International Congress on Antiphospholipid Antibodies Task Force on Pediatric Antiphospholipid Syndrome Report
17. 15th International Congress on Antiphospholipid Antibodies Task Force on Catastrophic Antiphospholipid Syndrome Report
18. 15th International Congress on Antiphospholipid Antibodies Task Force on Antiphospholipid Syndrome Treatment Trends Report
Part VI. Antiphospholipid syndrome for patients
19. Antiphospholipid syndrome: what should patients know?
20. Obstetric antiphospholipid syndrome: what should patients know?
Index.

Summary: Antipsychotic Long-acting Injections (LAIs) were introduced in the 1960s to improve treatment adherence in schizophrenia. This work brings together clinical and research findings on second generation LAIs in a comprehensive volume with chapters written by international experts.

Summary: "An antiracist society starts with you. That's the message in this powerful-yet practical-handbook. Using evidence-based interventions and exercises, two psychologists and experts in race, identity, equity, and inclusion empower readers to make their own personal contribution to creating an antiracist society. By shifting thought patterns and behaviors to cultivate an antiracist mindset, readers can actively change their community-and the world-by changing themselves"-- Provided by publisher.

Contents:
Part 1. Laying the foundation for antiracism
Chapter 1. Reflecting on race and racism as the first steps to antiracism
Chapter 2. Educating yourself-taking responsibility
Chapter 3. What's power (and privilege) got to do with it?
Part 2. Addressing barriers, shifting perspectives, and liberating our minds
Chapter 4. "I just can't think about it": overcoming avoidance
Chapter 5. Freeing our minds from being stuck in guilt
Chapter 6. Challenging victim-blaming and respectability politics: moving past stereotypes and biases
Chapter 7. Confronting fear: just do it
Part 3. Taking action to cultivate an antiracist life
Chapter 8. Navigating people, places, and spaces from an antiracist perspective
Chapter 9. Changing our communities through antiracist practices and policies
Chapter 10. Antiracism parenting: cultivating courage and a love for justice
Chapter 11. Faith works: cultivating antiracism in sacred spaces
Part 4. Refilling your well: being antiracist is a long-term commitment
Chapter 12. Sustainability: the marathon continues.

Summary: This volume provides a comprehensive, state-of-the-art overview of the major issues specific to the field of antireflux surgery. It provides exceptional instructional detail regarding performance of antireflux surgery from leading esophageal surgeons around the world. This volume represents the only resource of its kind dedicated specifically to the issues unique to antireflux surgery. It is rich in detail and helpful illustrations that instruct surgeons in proper technique as well as presenting the reasoning behind various techniques. Written by experts in the field, Antireflux Surgery is of great value to practicing surgeons who perform gastrointestinal surgery, medical students, surgical residents, and fellows.

Contents:
1. Surgical Anatomy of the Esophageal Hiatus
2. Effects of Reflux on the Esophageal Mucosa.- 3. Epidemiology and Socioeconomics of Reflux Disease
4. Medical Therapy for GERD.- 5. Indications for Antireflux Surgery. 6. The Relation of Hiatal Hernia to Gastroesophageal Reflux Disease.- 7. The Lower Esophageal Sphincter
8. Preoperative Evaluation and Testing for GERD.- 9. Complete Fundoplications: Indications and Technique
10. Posterior Partial Fundoplications: Indications and Technique
11. Anterior Partial Fundoplications: Indications and Technique
12. Paraesophageal Hernia: indications and technique
13. The Hill Antireflux Operations Repair and its Variants
4. Endoscopic Therapies for Reflux Disease
15. Magnetic LES Augmentation: The LINX Procedure
16. GERD Treatment in the Bariatric Population
17. Perioperative Complications and their Management.- 18. The Use of Mesh in Hiatal Hernia Repair.- 19. The Short Esophagus
20. Poor Esophageal Motility: A Tailored Approach?
21. Delayed Gastric Emptying and Reflux Disease.- 22. Reoperative Antireflux Surgery
23. Side Effects of Fundoplication and How to Deal with Them.- 24. Outcomes of Antireflux Surgery.

Summary: This significantly revised fourth edition provides a practically orientated guide to interactions associated with antiseizure medications. It describes pharmacokinetic and pharmacodynamic antiseizure medication (ASM) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations that are not associated with interactions and therefore can be co-prescribed without undue concern. Presented in alphabetical order and by drug class, drug interactions that occur between ASMs and also between ASMs and non- ASMs are described in three sections: Drug interactions between ASMs; Drug interactions between ASMs and non- ASM Drugs: Interactions affecting ASMs; Drug interactions between ASMs and non ASM Drugs: Interactions affected by ASMs. The latest data on all drug interactions is presented. New agents discussed include cannabidiol, cenobamate, everolimus and fenfluramine,. Antiseizure Medication Interactions: A Clinical Guide, 4th Edition concisely presents the most recent developments and data available on the topic. Therefore, enabling physicians and allied health professionals to make more rational choices when ASM polytherapy regimens are required. It will be of interest to medical professionals in disciplines including neurology, psychiatry and pediatrics.

Contents:
Section 1. Introduction
Section 2. Drug Interactions Between AEDs
Acetazolamide
Cannabidiol
Carbamazepine
Clobazam
Clonazepam
Ethosuximide
Eslicarbazepine acetate
Felbamate
Fenfluramine
Gabapentin
Lacosamide
Lamotrigine
Levetiraceta
Methsuximide
Oxcarbazepine
Perampanel
Phenobarbital
Phenytoin
Piracetam
Pregabalin
Primidone
Rufinamide
Stiripentol
Tiagabine
Topiramate
Valproic Acid
Vigabatrin
Zonisamide
Section 3. Drug Interactions between AEDs and non-AED drugs: Interactions Affecting AEDs
Acetazolamide
Cannabidiol
Carbamazepine
Clobazam
Clonazepam
Ethosuximide
Eslicarbazepine acetate
Felbamate
Fenfluramine
Gabapentin
Lacosamide
Lamotrigine
Levetiracetam
Methsuximide
Oxcarbazepine
Perampanel
Phenobarbital
Phenytoin
Piracetam
Pregabalin
Primidone
Rufinamide
Stiripentol
Tiagabine
Topiramate
Valproic Acid
Vigabatrin
Zonisamide
Section 4. Drug Interactions between AEDs and non-AED drugs: Interactions Affected by AEDS
Analgesics
Antimicrobials
Antineoplastic agents
Antiulcer drugs
Cardiovascular drugs
Immunosuppressants
Neuromuscular Blocking Agents
Psychotropic Drugs
Steroids
Miscellanea.

Contents:
Introduction
Physical Disinfection
Chemical Disinfection
Antiseptics and antisepsis
Physical sterilization
Chemical sterilization
Mechanisms of action
Mechanisms of microbial resistance

Summary: "Various antiseptic agents, such as chlorhexidine, are used for different applications, e.g. in healthcare, veterinary medicine, animal production and household products, including cosmetics. However, not all antiseptic agents provide significant health benefits, especially in some products used in human medicine (alcohol-based hand rubs, antimicrobial soaps). While some products (antimicrobial soaps, surface disinfectants, instrument disinfectants, wound antiseptics) may contain one or more biocidal agents with a comparable antimicrobial efficacy but large differences in their potential for microbial adaptation and tolerance. An increased bacterial resistance has been described for various antimicrobial agents, sometimes including a cross-resistance to antibiotics. The book is the first comprehensive reference resource on antiseptic agents, including their efficacy, natural and acquired resistance, adaptation, and cross-resistance. It also discusses their and appropriate use in terms of a balance between their efficacy and the risk of acquired bacterial resistance / tolerance. Focusing on human and veterinary medicine and household products, it helps readers make informed decisions concerning against antiseptic products based on their composition. The book contributes to reduce any unnecessary selection pressure towards emerging pathogens and to keep the powerful antiseptic agents for all those applications that have a clear benefit (e.g. reduction of healthcare-associated infection)."-- Provided by publisher.

Contents:
Introduction
Ethanol
Propan-1-ol
Propan-2-ol
Peracetic acid
Hydrogen peroxide
Glutaraldehyde
Sodium hypochlorite
Triclosan
Benzalkonium chloride
Didecyldimethylammonium chloride
Polihexanide
Chlorhexidine digluconate
Octenidine dihydrochloride
Silver
povidone iodine
Antiseptic stewardship for alcohol-based hand rubs
Antiseptic stewardship for skin antiseptics
Antiseptic stewardship for surface disinfectants
Antiseptic stewardship for instrument disinfectants
Antiseptic stewardship for antimicrobial soaps
Antiseptic stewardship for wound and mucous membrane antiseptics.

Summary: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting proteinprotein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Contents:
1 Antiviral Drugs Against Herpesviruses
2 An Update on Antiretroviral Therapy
3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition
4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection
5 Moving Fast Towards Hepatitis B Virus Elimination
6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection
7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery
8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all
9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses
10 Peptide Based Antiviral Drugs
11 Covalent Antiviral Agents
12 Safe-in-Man Broad Spectrum Antiviral Agents
13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .

Summary: This book reviews all important aspects of anxiety disorders with the aim of shedding new light on these disorders through combined understanding of traditional and novel paradigms. The book is divided into five sections, the first of which reinterprets anxiety from a network science perspective, examining the altered topological properties of brain networks in anxiety disorders. The second section discusses recent advances in understanding of the neurobiology of anxiety disorders, covering, for example, gene-environmental interactions and the roles of neurotransmitter systems and the oxytocin system. A wide range of diagnostic and clinical issues in anxiety disorders are then addressed, before turning attention to contemporary treatment approaches in the context of novel bio-psychosocial-behavioral models, including bio- and neurofeedback, cognitive behavioral therapy, neurostimulation, virtual reality exposure therapy, pharmacological interventions, psychodynamic therapy, and CAM options. The final section is devoted to precision psychiatry in anxiety disorders, an increasingly important area as we move toward personalized treatment. Anxiety Disorders will be of interest for all researchers and clinicians in the field.

Contents:
Part 1. Brain network concepts
Chapter 1. Task MRI-based functional brain network of anxiety
Chapter 2. Phenotype network and brain structural covariance network of anxiety
Chapter 3. linear/nonlinear micro-and-macro state EEG-based functional networks for anxiety
Chapter 4. White matter-based structural brain network of anxiety
Chapter 5. Resting state abnormalities in anxiety disorders and spatiotemporal psychopathology
Part 2. Neurobiological Aspects
Chapter 6. Gene-environmental interactions and role of epigenetics in anxiety disorders
Chapter 7. The role of the oxytocin system in anxiety disorders
Chapter 8. Translational studies in the complex roles of neurotransmitter systems in anxiety and anxiety disorders
Chapter 9. The role of early life stress in HPA axis dysfunction in anxiety disorders
Chapter 10. Immune-kynurenine pathways and the gut-microbiota-brain axis in anxiety disorders
Chapter 11. Experimental anxiety model for anxiety disorders: relevance to drug discovery
Part 3. Diagnostic and clinical Issues
Chapter 12. Anxiety disorders in DSM-5: changes, controversies, and future directions
Chapter 13. Biological markers to differentiate the type of anxiety disorders
Chapter 14. Comorbid anxiety and depression: clinical and conceptual consideration, transdiagnostic treatment
Chapter 15. Anxiety disorders and medical comorbidity: treatment implications
Part 4. Therapeutic Issues
Chapter 16. Biofeedback and Neurofeedback for Anxiety Disorders: A Quantitative and Qualitative Systematic Review
Chapter 17. Cognitive Behavioral Therapy, Mindfulness-Based Cognitive Therapy and Acceptance Commitment Therapy for Anxiety Disorders: Integrating Traditional with Digital Treatment Approaches
Chapter 18. Neurostimulation in anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder
Chapter 19. Current and novel psychopharmacological drugs for anxiety disorders
Chapter 20. Role of benzodiazepines in anxiety disorders
Chapter 21. Virtual Reality for Anxiety Disorders: Rethinking a Field in Expansion
Chapter 22. Current research on complementary and alternative medicine (CAM) in the treatments of anxiety disorders: evidence based review
Chapter 23. Contemporary Psychodynamic Approaches to Treating Anxiety: Theory, Research, and Practice
Chapter 24. Well-being therapy in anxiety disorders
Part 5. Anxiety and precision psychiatry
Chapter 25. Personalized clinical approaches to anxiety disorders
Chapter 26. The role of hormonal and reproductive status in the treatment of anxiety disorders in women
Chapter 27. Risk factors and prevention strategies for anxiety disorders in childhood and adolescence
Chapter 28. Anxiety disorders in the elderly.

Contents:
Foreword by Donna Stewart (Toronto) and Helen Herman (Australia)
Introduction
Generalised Anxiety Disorder
Panic Disorder
Social Anxiety Disorder
Obsessive-compulsive and Related Disorders
Trauma and Stressor-Related Disorders
Anxiety disorders during pregnancy and lactation
Anxiety and related disorders in women
Anxiety and related disorders in men.

Contents:
Vol. 1. Principles
v. 2. Specific fractures.

Summary: This book comprehensively covers aortic dissection and acute aortic syndromes. Topics covered include the pathology, genetics, diagnosis, medical treatment and surgical management of uncomplicated and complicated aortic dissection, including endovascular stenting. In addition, imaging and follow-up procedures after initial surgical treatment are reviewed along with acute and chronic type A and type B dissection. Potential complications that can be encountered at various treatment stages and management strategies are also detailed. Aortic Dissection and Acute Aortic Syndromes comprehensively reviews aortic dissection in an easy to read, illustration-rich book. It is therefore an essential resource for both trainee and experienced cardiologist, cardiac surgeon and any other medical professionals involved in the management of these patients. .

Contents:
Overview and History of Aortic Dissection and other Acute Aortic Syndromes
Aortic anatomy and the pathophysiology of acute aortic syndromes
Histopathology of Acute Aortic Syndromes
Genetically-Triggered Aortic Dissections
Presentation of Acute Aortic Syndromes
Classification Systems of Acute Aortic Syndromes
Medical conditions predisposing to aortic dissection and preventive strategies
What do the Guidelines say for the Treatment of Acute Aortic Syndromes?
Initial Medical Management of Acute Aortic Syndromes
Imaging of Aortic Dissection: CT, MRI, and Angiography
Imaging of Intramural Hematoma and Penetrating Atherosclerotic Ulcer by CT and MRI
Echocardiography for the Diagnosis and Management of Acute Aortic Syndromes
Long-term imaging of the aorta - considerations and comparison of modalities
Blunt Traumatic Aortic Injury: Etiology, Diagnosis, and Management
Catheter-Induced Aortic Dissection
Aortic Intramural Hematoma
Penetrating Atherosclerotic Ulcer: Presentation and Management
Endovascular treatment of type A aortic dissections
Valve Sparing Aortic Root Replacement for Aortic Valve Insufficiency in type A Aortic Dissection
Basic Approaches for the Surgical Management of Acute Type A Aortic Dissection - Safe Management Strategies for the General Cardiac Surgeon
Valve Repair for Aortic Valve Insufficiency in the Setting of Acute Aortic Dissection
Management of the Aortic Arch in Acute Aortic Dissection Type A
Frozen Elephant Trunk for Aortic Dissection
One-stage Repair of Extensive Chronic Thoracic Aortic Dissection
Management of Complicated Type A Aortic Dissection
Management of Complicated Acute Type A Aortic Dissection
Management of Type B Aortic Dissection
Subacute and Chronic Type A Aortic Dissection
Management of chronic descending thoracic and thoracoabdominal dissection and aneurysm-stent grafting, debranching
Management of Chronic Dissection of the Descending Thoracic and Thoracoabdominal Aorta
Diagnosis and Management of Ruptured Thoracic Aortic Aneurysms
Monitoring and medical treatment of chronic thoracic, abdominal, and thoracoabdominal aortic aneurysms
External Aortic Support and Other Alternative Strategies in the Management of Aortic Pathology of Patients with Connective Tissue Disorders
Management of Operative Complications after Type A aortic dissection repair
Neuroprotection during dissection repair
Acute Type A Aortic Dissection: When Not to Operate
Delayed Surgery for Acute Aortic Dissection
Anesthetic Management of Acute Aortic Dissection
Coagulopathy and bleeding management for aortic dissection surgery
Monitoring After Surgery for Acute Aortic Syndromes
Medical Management of Uncomplicated Type B Acute Aortic Syndromes
Symptomatic Thoracic Aortic Aneurysms
Future Considerations for Acute Aortic Syndromes.

Summary: This title is a comprehensive resource of aortic regurgitation suitable for both the novice and experienced practitioner. Detailed attention is given to the recently growing field of aortic valve-sparing surgery and aortic valve repair. Guidelines are also provided for general practitioners on how to treat patients after various aortic procedures. Also included are many operative photos, original medical illustrations and schematics. Aortic Regurgitation synthesizes current knowledge of aortic valve repair into an easy-to-follow, illustration-rich text. It is therefore an indispensable guide suitable for use by cardiologists and trainees in cardiology, cardiac surgeons, echocardiographers, general practitioners and radiologists.

Contents:
Foreword
Terminology and list of abbreviations
Intermezzo I: Leonardo
Clinical and surgical anatomy of the aortic root
Living anatomy of the aortic root
Intermezzo II: Eponyms related to aortic regurgitation
Functional anatomy of the aortic valve and dynamics of the aortic root
Congenital anomalies of the aortic valve
Intermezzo III: Dominic John Corrigan (1802-1880)
Aortic regurgitation: from diagnosis towards indication
Connective tissue disorders
Echocardiography of the aortic valve
Intermezzo IV: Alfred de Musset (1810-1857)
Computed tomography and magnetic resonance of the aortic valve and ascending aorta
Therapy
Intermezzo V: Lincoln sign
Longterm results of aortic valve replacement and repair
Intermezzo VI: Taliesin Golesworthy, the inventor of treatment of his own disease
Recommendations for out-patient care after aortic valve surgery.

Contents:
1. General considerations and etiologies of aortic stenosis
2. Clinical assessment of the severity of aortic stenosis
3. Physiological basis for area and gradient assessment: hemodynamic principles of aortic stenosis
4. Different classifications of aortic stenosis
5. Invasive evaluation of aortic stenosis
6. Echocardiographic evaluation of aortic valve stenosis
7. Complimentary role of CT/MRI in the assessment of aortic stenosis
8. Area and gradient mismatch: the discordance of a small valve area and low gradients
9. Reverse area and gradient mismatch: the discordance of a large valve area and high gradients
10. Prosthetic aortic valves and diagnostic challenges
11. Risk prediction models, guidelines, special populations, outcomes
12. Surgical management of aortic valve stenosis
13. Balloon aortic valvuloplasty
14. Imaging for transcatheter aortic valve replacement
15. Transcatheter aortic valve replacement
Index.

Summary: This book provides comprehensive, state-of-the art insights into aortic valvuloplasty. Aortic valve repair is a relatively new procedure. Since first being successfully performed in the 1990s was objectively assessed in the 2000s, this procedure has now become standardized, reproducible, and popular around the globe. Written by experts in surgery and cardiology and richly illustrated, it discusses the aspects of anatomy, pathophysiology, diagnosis and surgical procedure that are essential for successful repair. Contributing to the popularization and development of aortic repair, it is a valuable resource for surgeons, cardiologists, cardio-anesthetists and paramedical staff interested in the field and will be good resource for popularizing and developing aortic valve repair.

Contents:
Part I. Introduction
1. Anatomy of the Aortic Valve and its Morphological Characteristics
2. Pathophysiology and Natural History of Aortic Regurgitation
3. Ultrasound Measurement of Aortic Valves
4. Computed Tomographic Measurements of Aortic Valves
5. Optimizing Aortic Valve Repair Techniques with Computational Models
6. Aortoscopy to Evaluate Cusp Configuration after Aortic Valvuloplasty
7. Indications and Contraindications for Aortic Valve Repair
8. ONE-POINT ADVICE: Significance of Aortic Valvuloplasty in the Valve-in-Valve Era
9. Trends in Aortic Valve-sparing Surgery
Part II. Concepts and Approaches
10. Bicuspid Aortic Valve
11. ONE-POINT ADVICE: Tricuspidization of a Bicuspid Valve
12. Tricuspid Aortic Valve
13. Others ? Unicuspid valve and Quadricuspid valve
14. ONE-POINT ADVICE: The Limitations and Potential of MICS during Aortic Valvuloplasty
15. Aortic Valve Reconstruction to Treat Aortic Stenosis Using Autologous Pericardium ? Ozaki Procedure
16. ONE-POINT ADVICE: Creating a Morphological Template for Autologous Pericardial Cusps
17. ONE-POINT ADVICE : Experimental Comparison Between the Reimplantation Method and Remodeling Method
18. History, Techniques, and Outcomes of the Reimplantation Method
19. History, Techniques, and Outcomes of the Remodeling Method
20. Variations and Outcomes of Annuloplasty
21. ONE-POINT ADVICE : Other Valve-sparing Aortic Root Replacement Techniques
22. ONE-POINT ADVICE : The Advantages and Disadvantages of Valsalva Grafts
23. Valve Surgery to Treat Connective Tissue Disease ? Comparison Between Valve Replacement and Aortic Root Replacement
24. Significance of Aortic Valvuloplasty in the Elderly
25. Valve-sparing Aortic Root Replacement to Treat Acute Type A Aortic Dissection
26. Pediatric Valvuloplasty
27. The Significance of Performing Aortic Valvuloplasty in Young Patients
Part III. Case Study ? What to Do in Each Particular Case?
28. How to Manage Patients with Low Geometric Cusp Height
29. How to Manage a Stenosed Bicuspid Valve
30. How do I Manage a Case with Borderline Dilatation of the Sinus of Valsalva?
31. How do I Manage Perforation and Fenestration?
32. How to Manage Moderate Aortic Regurgitation in the Context of Combined Valvular Disease
33. When is Partial Rremodeling Possible?
34. Aortic Valvuloplasty to Treat Aortic Regurgitation Accompanied by a Ruptured Sinus of Valsalva Aneurysm
35. Valvuloplasty to Treat Aortic Regurgitation Associated with a Ventricular Septal Defect
36. Valvuloplasty for Aortic Regurgitation Associated with Infective Endocarditis
37. Valvuloplasty to Treat Traumatic Aortic Regurgitation
38. How to Manage Aortic Regurgitation from an Allograft
Part IV. Aortic Valve Repair: Specialists in the World
39. Leaders in Valvuloplasty around the World
Part V. Closing Remarks
40. Cardiologists? Expectations of Aortic Valvuloplasty.

Contents:
Cover
Title Page
Copyright Page
Contents
List of Contributors
Foreword
Chapter 1 Introduction
References
Part I General Complications
Chapter 2 Vascular Complications
Introduction
Preventing and Managing Vascular Complications
Conclusions
References
Chapter 3 Annular Rupture
Introduction
Anatomy of the Aortic Valvar Complex
Pathophysiology of Annular Rupture
Sites and Classification of Annular Rupture
MDCT Assessment of the Aortic Annulus
Management of Annular Rupture
Prevention of Aortic Rupture
Conclusions
References Chapter 4 Coronary Obstruction
Introduction
Risk Factors and Mechanism
Clinical Presentation
Preventive Measures and Treatment
Take Home Message
References
Chapter 5 Cerebrovascular Events
Introduction
Definition of Stroke and Epidemiology
Silent Stroke
Postprocedural Stroke Predictors
Predictors of Stroke in the Acute Phase
Predictors of Tardive Stroke
Postprocedural Stroke Prevention
Conclusions
References
Chapter 6 Ventricular Perforation
Introduction
General Mechanisms and Clinical Presentation of VP Risk Factors for Ventricular Perforation
Clinical Factors
Anatomical Factors
Procedural Factors
Aortic Valve Crossing
Wire Exchange
THV Pre-deployment and Deployment
Right Ventricular Perforation
Management of Ventricular Perforation
LV Perforation and Surgical Repairing Techniques
Outcomes of Ventricular Perforations
Prevention of Ventricular Perforations
Conclusions
References
Chapter 7 Valve Migration
Introduction
Clinical Relevance
Monitoring
Treatment
Conclusion
Acknowledgements
References
Chapter 8 Paravalvular Leaks Clinical Relevance
Prevention
Monitoring
Treatment
Valve-In-Valve Implantation (ViV)
Conclusion
References
Chapter 9 Conduction Disturbances
Introduction
Mechanism
Incidence
Predictors
Predictors of New-Onset LBBB
Role of Electrophysiology Studies and Management of Conduction Disturbances After TAVI
Summary
References
Chapter 10 Leaflet Thrombosis
Background
Diagnosis
Incidence
Predictors
Clinical Consequences
Management
Conclusions
References
Chapter 11 Bleeding
Introduction
Clinical Relevance
Prevention Treatment
References
Chapter 12 Renal Dysfunction
Clinical Relevance
Prevention
Monitoring
Treatment
References
Part II Specific Complications
Chapter 13 Bicuspid Valve
Clinical Relevance
Prevention
Monitoring
Treatment
References
Chapter 14 Degenerated Aortic Bioprosthesis
Introduction
Definition of Structural Valve Degeneration
Diagnosis of SVD
Durability of Bioprosthesis
Transcatheter Bioprosthesis
Management of SVD
References
Chapter 15 Low-Flow Low-Gradient Aortic Stenosis
Introduction
References

Summary: This is the first textbook to focus on Aortopathy, a new clinical concept for a form of vasculopathy. The first section of the book starts from discussing general concept and history of Aortopathy, and then deals with its pathophysiology, manifestation, intrinsic factor, clinical implication, management and prevention. The second part closely looks at various disorders of the Aortopathy such as bicuspid aortic valve and coarctation of aorta. The book editors have published a lot of works on the topic and have been collecting relating data in the field of congenital heart disease for the past 20 years, thus present the book with confidence. The topic - an association of aortic pathophysiological abnormality, aortic dilation and aorto-left ventricular interaction - is getting more and more attention among cardiovascular physicians. This is the first book to refer for cardiologists, pediatric cardiologists, surgeons, ACHD specialists, etc. to acquire thorough knowledge on Aortopathy.

Contents:
Part I Overview
1 History of Aortopathy
2 Pathological Background
3 Physiological Background
4 Aortopathies: Clinical Manifestation
5 Genetics of Marfan Syndrome, Related Disorders and Bicuspid Aortic Valve
Part II Diagnosis and Management
6 Imaging in Aortopathy: Echo, CT and MRI
7 Pulse Wave Velocity and Augmentation Index
8 Comprehensive Assessment of Aortopathy Using Catheterization
9 Aortopathy in Pregnancy and Delivery
10 Medications
11 Clinical Diagnosis and Surgical Therapy of the Ascending Aorta and the Aortic Arch
12 Surgery (Bentall, Valve Sparing, Ross Procedure etc.)
13 Stenting
Part III Various Disorders That Represent Aortopathy
14 The Marfan Syndrome.-15 Bicuspid aortic valve
16 Aortic Coarctation.-17 Tetralogy of Fallot and pulmonary atresia with ventricular septal defect
18 Hypoplastic Left Heart Syndrome
19 Aortopathy in Transposition of the Great Arteries after Arterial Switch Operation
20 Aortopathy in Patients after the Fontan Operation
21 Future Research Project in Aortopathy.

Contents:
Evaluation and decision making for metastatic spine tumors / Yan Michael Li, Michael S. Dirks, Claudio E. Tatsui, and Laurence D. Rhines
Neoplastic spinal instability / Daryl R. Fourney and Charles G. Fisher
Major complications associated with stereotactic ablative radiotherapy (SABR) for spinal metastasis / Simon S. Lo, Arjun Sahgal, and Eric L. Chang
En bloc resection in the treatment of spinal metastases : technique and indications / Ilya Laufer, Jean-Paul Wolinksy, and Mark H. Bilsky
Region specific approaches / Daniel Sciubba
Spinal reconstruction and fixation/fusion / Rajiv Saigal and Dean Chou
Minimally invasive surgery for metastatic spine disease / Meic H. Schmidt
Vertebral augmentation for metastatic disease / Ehud Mendel, Eric Bourekas, and Paul Porensky
Surgical complications and avoidance / Michelle J. Clarke.

Contents:
Evaluation and decision making / Stefano Boriani and Charles Fisher
Safety and efficacy of surgery for primary tumors of the spine / Daryl R. Fourney, Charles Fisher, and Stefano Boriani
Interventional options for primary tumors / Sudhir Kathuria
Radiation therapy for primary bone tumors / Brent Y. Kimball and Yoshiya Yamada
Medical oncology principles for the spine oncology surgeon / Scott H. Okuno, Steven Robinson and Shreyaskumar Patel
Spinal osteoid osteoma and osteoblastoma / Melissa Nadeau and Christian DiPaola
ABC, giant cell / Stefano Boriani, Stefano Bandiera, Riccardo Ghermandi, Simone Colangeli, Luca Amendola, and Alessandro Gasbarrini
Chordoma / Jackson Sui, Patricia L. Zadnik, Mari L. Groves, and Ziya L. Gokaslan
Chondrosarcoma / Stefano Boriani, Stefano Bandiera, Riccardo Ghermandi, Simone Colangeli, Luca Amendola, and Alessandro Gasbarrini
Osteogenic and ewing sarcomas of the spine / Derek G. Ju, Patricia L. Zadnik, and Daniel M. Sciubba
Margins in spine tumor resection : how much is enough? is planned
Transgression okay? / Ilya Laufer, Mari Groves, and Jean-Paul Wolinsky
Principles behind determining the right approach / Nicolas Dea and Rowan Schouten
Spino-pelvic reconstruction/fixation and fusion / Peter Paul Varga
Structural graft selection and wound closure techniques
Complications and avoidance: how to plan primary tumor resection to minimize complications and maximize outcome / Michael C. Oh, Vedat Deviren, and Christopher P. Ames.

Contents:
Epidemiology, microbiology, and pathology of spinal infections / Abdulrazzaq Alobaid and Abdulaziz Al-Mutair
Risk stratification and prevention of postoperative spinal infections / Hideyuki Arima, Leah Y. Carreon, and Steven D. Glassman
Imaging in spinal infections / Anupama Maheswaran and Alberto Zerbi
Instrumentation and spinal infections / Hisam Muhamad Ariffin, Yoshiharu Kawaguchi and ChungChek Wong
Pyogenic spondylodiskitis : pathogenesis and clinical features / Mauro Antonio Fernandes, Luiz Roberto Vialle, and Phelipe de Souza Menegaz
Pyogenic spondylodiskitis : diagnosis and management / Joost P.H.J. Rutges, Diederik Hendrik Ruth Kempen, and F. Cumhur Oner
Spinal epidural abscess / Frank Kandziora, Klaus John Schnake, and Christoph-H. Hoffmann
Spinal tuberculosis : pathogenesis, clinical features, and investigations / Rishi M. Kanna, Ajoy Prasad Shetty, and S. Rajasekaran
Drug therapy for spinal tuberculosis / Mathew Varghese
Surgical management of spinal tuberculosis / Ajoy Prasad Shetty, Rishi M. Kanna, and S. Rajasekaran
Pediatric spinal infections / S. Rajasekaran, Rishi M. Kanna, and Ajoy Prasad Shetty
Infectious lesions in the craniovertebral junction (suboccipital region) / Alexsander Yu Mushkin and Alexander V. Gubin
Minimally invasive surgery in spinal infections / Moritz Perrech and Roger Hartl
Human immunodeficiency virus and spinal infections / Robert Dunn
Postoperative spondylodiskitis / Mayan Lendner, Jeffrey Green, Kris E. Radcliff, Joseph S. Butler, Hamadi Murphy, and Alexander R. Vaccaro
Postoperative peri-implant infections / Claudio Lamartina, Alex Vesnaver, and Carlotta Martini
Spinal infections in geriatric patients / Yoshiharu Kawaguchi
Spinal infections and pseudoarthrosis / Sigurd Berven.

Contents:
Laminoplasty for multilevel myelopathy and radiculomyelopathy / Kazuhiro Chiba
Anterior cervical decompression and fusion techniques : anterior cervical decompression and fusion, corpectomy, and foraminotomy / Han Jo Kim, John M. Rhee, and K. Daniel Riew
Indications and techniques of cervical pedicle screws c3-7 for degenerative conditions / Kuniyoshi Abumi and Manabu Ito
Laminectomy and fusion for cervical spondylotic myelopathy / Kristian Dalzell, Aria Nouri, and Michael G. Fehlings
Posterior cervical minimally invasive microendoscopic foraminotomy / Albert P. Wong, Tarek Y. El Ahmadieh, Zachary A. Smith, Nader S. Dahdaleh, and Richard G. Fessler
Navigation for cervical reconstruction surgery / Shanmuganathan Rajasekaran and Ajoy Prasad Shetty
Cervical disk arthroplasty / Justin W. Miller and Rick C. Sasso
Cervical sagittal balance : what is normal and what is the effect on reconstruction outcomes / Peter L. Cohn, William Ryan Spiker, Kris E. Radcliff, and Alexander R. Vaccaro
Complications of anterior surgery : vertebral artery injury, esophageal perforation, dysphagia / Luiz Roberto Vialle, Samuel Conrad, and Emiliano Vialle
Adjacent segment pathology of the cervical spine / Babak Khamsi, Sandeep N. Gidvani, and Jeffrey C. Wang
Upper cervical screw-fixation techniques : how to avoid complications / Han Jo Kim and Jin Sup Yeom.

Contents:
Preoperative evaluation and optimization for surgery / Scott C. Wagner, Daniel G. Kang, Ronald A. Lehman, Jr., and Lawrence G. Lenke
Decision making in adult deformity surgery : decompression versus short or long fusion / Kenneth M.C. Cheung and Jason P.Y. Cheung
The use of osteotomies for rigid spinal deformities / Stephen J. Lewis and Simon A. Harris
Indications and techniques for sacral-pelvic fixation in adult spinal deformity / Kristen E. Jones, Robert A. Morgan, and David W. Polly, Jr.
Instrumentation strategies in osteoporotic spine : how to prevent failure? / Ahmet Alanay and Caglar Yilgor
The incidence and management of acute neurologic complications following complex adult spinal deformity surgery / Joseph S. Butler and Lawrence G. Lenke
Postoperative coronal decompensation in adult deformity / Yong Qiu
Measuring outcome and value in adult deformity surgery / Robert Waldrop and Sigurd Berven
Junctional issues following adult deformity surgery / Han Jo Kim, Sravisht Iyer, and Christopher I. Shaffrey, Sr.
Biomechanics and material science for deformity correction / Manubu Ito, Yuichiro Abe, and Remel Alingalan Salmingo
Pseudarthrosis and infection / Michael P. Kelly and Sigurd Berven.

Contents:
Anatomy of the cervical spine / Ronald L.A.W. Bleys
Biomechanics of the cervical spine : from the normal state to the injury state / Ahmer K. Ghori, Dana Leonard, and Thomas Cha
Evaluation of an injured cervical spine / Richard Assaker, Fahed Zairi, and Xavier Demondion
Nonoperative management of cervical spine trauma / Melvin D. Helgeson and Peter Formby
Occipital condyle fractures and occipitocervical dissociation / Philipp Schleicher, Matti Scholz, and Frank Kandziora
Atlas injuries / Matti Scholz, Philipp Schleicher, and Frank Kandziora
Odontoid fractures, hangman's fractures, and C2 body fractures / Wilco C. Peul and Carmen L.A. Vleggeert-Lankamp
Compression (AO type-A injuries) / Nuno Neves
Subaxial cervical spine injuries : distraction (AO type-B injuries) / William A. Robinson, Kevin P. McCarthy, Alexander R. Vaccaro, and C. Chambliss Harrod
Facet and lateral mass fractures / Maximo-Alberto Diez-Ulloa
Cervical dislocations (AO type-C injuries) / William Munoz, Michael J. Vives, and Saad B. Chaudhary
Cervicothoracic junction injuries / Ripul Rajen Panchal
Cervical trauma in combination with ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis / Jorrit-Jan Verlaan and F. Cumhur Oner
Rheumatoid arthritis and osteoporosis / David T. Anderson
Pediatric cervical spine / Ahmet Alanay and Caglar Yilgor.

Contents:
The AO spine thoracolumbar injury classification / Adam J. Bevevino, Alexander R. Vaccaro, and Robyn Rubenstein
Radiographic assessment of thoracolumbar fractures / S. Rajasekaran, Rishi Mugesh Kanna, Anupama Maheswaran, and Ajoy P. Shetty
Posterior minimally invasive surgery in thoracolumbar fractures / Matti Scholz, Philipp Schleicher, and Frank Kandziora
Anterior minimally invasive surgery in thoracolumbar fractures / Phillipp Schleicher and Frank Kandziora
Cervicothoracic spine fractures / Rod J. Oskouian and Jens R. Chapman
Transpedicular and costotransversectomy approaches for trauma : indications and techniques / Richard Jackson Bransford, Alireza K. Anissipour, Zachary A. Child and Carlo Bellabarba
Short or long posterior fusion : determining the extent of fixation / Luiz Roberto Vialle, Emiliano Vialle, Joana B.C .R. Guasque and Luiz Gustavo Dal Oglio Rocha
Burst fracture treatment / F. Cumhur Oner and J.J. Verlaan
Differentiating lumbar fractures from thoracolumbar fractures / Jonathan Belding, Darrel S. Brodke, and Brandon D. Lawrence
Thoracolumbar fracture fixation in the osteoporotic patient / Theodore J. Choma
Correction of posttraumatic deformity / Klaus John Schnake and Robert Morrison
Fractures in ankylosing conditions / Zachary A. Child and Richard Jackson Bransford
Spinopelvic fixation / Carlo Bellabarba and Richard Jackson Bransford.

Contents:
Pathobiology of spinal cord injury / Hiroaki Nakashima, Narihito Nagoshi, and Michael G. Fehlings
Assessment of functional status and outcomes of individuals with traumatic spinal cord injury / Christian Schuld and Norbert Weidner
Serum and CSF biomarkers to predict functional recovery after spinal cord injury / Seth S. Tigchelaar and Brian K. Kwon
Magnetic resonance imaging of the injured spinal cord : the present and the future / Allan R. Martin, Julien Cohen-Adad, and Michael G. Fehlings
Acute nonoperative management of traumatic spinal cord injury : state of the art / Joshua S. Catapano, Gregory W.J. Hawryluk, and Michael G. Fehlings
Role and timing of surgery for traumatic spinal cord injury : what do we know and what should we do? / Christopher D. Witiw and Michael G. Fehlings
Methylprednisolone as a valid option for acute spinal cord injury : a reassessment of the literature / Michael G. Fehlings and Newton Cho
Neuroprotection of the injured spinal cord : what does the future hold? / Michael G. Fehlings and Christopher S. Ahuja
Hydrogel biomaterials in spinal cord repair and regeneration / Manuel Ingo Gunther, Thomas Schackel, Norbert Weidner, and Armin Blesch
Neural stem cell transplantation for spinal cord repair / Ina Simeonova, Beatrice Sandner, and Norbert Weidner
Strategies to overcome the inhibitory environment of the spinal cord / Elizabeth J. Bradbury and Emily R. Burnside
Functional electrical stimulation and neuromodulation approaches to enhance recovery after spinal cord injury / Cesar Marquez-Chin, Emilie Sagripanti, and Milos R. Popovic
Advanced rehabilitation strategies for individuals with traumatic spinal cord injury / William Z. Rymer, Sheila Burt, and Arun Jayaraman
Brain-computer interfaces to enhance function after spinal cord injury / Rudiger Rupp.

Contents:
Economic issues, risk factors, and litigation / Marco Brayda-Bruno
Decision making and flag systems / Gustavo Zanoli
The supremacy of the clinical evaluation / Roberto Chapa Sosa and Neil N. Patel
Imaging in back pain / Alberto Zerbi
Myth and reality of sacroiliac joint pathology / Kristen E. Jones and David W. Polly, Jr.
State of the art of biology, genetics, and mechanics of the disk / Mauro Alini, Sibylle Grad, Hans-Joachim Wilke, Fabio Galbusera, and Alessandra Colombini
Neurologic back pain : myopathies, neuromuscular disease, Parkinson, and dystonia / Asdrubal Falavigna and Carlo Domenico Marrone
Back pain in children and adolescents / Katherine M. Schroeder, Erica E. Gonzalez, and John P. Dormans
Back pain in adults / Max Aebi
Back pain in spinal infections / Rishi Mugesh Kanna, Ajoy Prasad Shetty, Emiliano Vialle, and Shanmuganathan Rajasekaran
Conservative treatment : drugs, physiotherapy, and alternative medicine / Christopher C. Ornelas and Mona Zall
Outcome evaluation in back pain patients / Martin H. Pham, Andre M. Jakoi, Neil N. Patel, and Jeffrey C. Wang
Role of minimally invasive surgery in back pain for degenerative spine / Roberto Bassani and Elena Serchi
Back pain and sagittal alignment / Pedro Berjano
Patients with multiple surgeries / Claudio Lamartina and Carlotta Martini
Chronic back pain, failed surgery, and what to do when all options are exhausted / Lawrence G. Lenke.

Summary: Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

Contents:
Brain basics
Humanistic basics : accommodation, adjustment, and aristos
Aphasia theory, models, and classification
Neuroimaging and brain-based communication disorders
Care for people with aphasia and related neurogenic communication disorders in acute hospital settings
Multicultural and multilinguistic issues
General principles of assessment
Naming and word retrieval impairments
Comprehension
Acquired impairments of reading and writing
Syntax and linguistic-based approaches
pragmatics and discourse
Social and life participation approaches to aphasia intervention
Assistive technology
Treatment effectiveness and evidence-based practice
Telepractice
Digital and electronic advances in the management of aphasia and related neurogenic language disorders
Resources for families and clinicians
Funding and reimbursement of speech-language services
Primary progressive aphasia
Communication disorders associated with right hemisphere brain damage
Dementia
Traumatic brain injury, blast injuries, and multisystem injuries
Communication and cognition.

Contents:
1. The life history of ApoB lipoprotein particles
2. Diagnosis of the ApoB dyslipoproteinemias: the ApoB algorithm
3. The primary ApoB dyslipoproteinemias
4. Secondary ApoB dyslipoproteinemias
5. ApoB in cardiovascular risk prediction
6. ApoB lipoprotein particles: the preferred treatment target in primary and secondary prevention
7. The future of ApoB: moving from the risk prediction paradigm to the casual exposure paradigm.

Contents:
Foreword
Preface
1. Molecular Cell Biology of Apoptosis and Necroptosis in Cancer
2. Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis
3. Micro-environmental Effects of Cell Death in Malignant Disease
4. Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis
5. Axl and Mer Receptor Tyrosine Kinases: Distinct and Non-overlapping Roles in Inflammation and Cancer?
6. Immunogenic Apoptotic Cell Death and Anti-cancer Immunity
7. Cancer Cell Death-inducing Radiotherapy
Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity
8. Novel Approaches to Apoptosis-inducing Therapies
9. Killing Is Not Enough: How Apoptosis Hijacks Tumor-associated Macrophages to Promote Cancer Progression
Index.

Summary: This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.

Contents:
Prix fixe: Efferocytosis as a four-course meal
Emerging roles for RIPKs in pathogen-induced cell death and host immunity
Epithelial cell death and inflammation in skin
IAPs and cell death
Cellular FLICE-inhibitory protein regulates tissue homeostasis
Lipid peroxidation dependent cell death regulated by GPx4 and ferroptosis
Immune regulation by dead cell clearance.

Summary: Patient empowerment is examined as a multi-dimensional factor influencing the use of diabetes self-management apps. The research design includes three studies conducted in Singapore. Study 1 examines how features of diabetes self-management apps correspond with theoretical indicators of empowerment, as well as app quality. Study 2 uses semi-structured face-to-face interviews with diabetes patients to draw first conclusions about the relevance of empowerment for diabetes app use. Study 3 includes an online patient survey, and uses cluster analytical methods to test the preliminary Study 2 results (typology of app use), as well as binary logistic regression to compare the strength of influence of various anteceding factors on the likelihood of diabetes app use. The studies show that especially the support by private social patient networks and the medical specialties of supervising physicians play a crucial role for technology-supported self-management. Contents Defining and Categorizing Diabetes Apps for Self-Management Anteceding Factors of Diabetes App Use Empowerment and its Relevance for Diabetes Management Target Groups Researchers, students and practitioners in the fields of Public Health, Medicine, Health Communication, Endocrinology, Diabetes Care, Epidemiology, Health Management The Author Dr. Nicola Brew-Sam holds an MA in health communication (UZH Zurich) and a Ph.D. from University of Erfurt (Germany) in cooperation with Nanyang Technological University (Singapore).

Contents:
Intro
Acknowledgements
Table of Contents
Table of Contents
List of Figures
List of Tables
List of Abbreviations
Abstract
1 Introduction
1.1 The Urgency of Self-Management in Diabetes Care
1.2 Research Interest: Empowerment as an Anteceding Factor of Diabetes App Use for Self-Management
1.3 Chapter Overview
2 Background on Diabetes Self-Management
2.1 What is Diabetes?
Types of Diabetes Mellitus
2.2 Diabetes Self-Management
Definition and Development
2.3 Factors Influencing Diabetes Self-Management 3 Defining and Categorizing Diabetes Apps for Self-Management
3.1 Diabetes Apps for Self-Management as Second Generation mHealth Tools
3.2 Purpose, Types and Features of Diabetes Apps for Self-Management
3.3 Shortcomings of Diabetes Apps and Diabetes App Quality
4 Diabetes App Use
Previous mHealth Research
4.1 Defining Diabetes App "Use"
4.2 Categorizing Studies on Diabetes App Use: The Inputs-Mechanisms-Outputs Pathway
4.2.1 Input: Feasibility and Accessibility Studies
4.2.2 Output: Diabetes App Usage Effect Studies 4.2.3 Mechanisms: Lacking Research on Antecedents of Health App Use
5 Anteceding Factors of Diabetes App Use
5.1 Defining "Antecedents" of mHealth Use
5.2 The Relevance of Studies Looking into Antecedents of mHealth Use
5.3 Previous Studies Looking into Antecedents of mHealth Use
5.4 Antecedents of the Unified Theory of Acceptance and Use of Technology
5.5 Shortcomings of the Unified Theory of Acceptance and Use
6 Summarizing mHealth Research Gaps I: Alternative Theory is Needed
7 Empowerment as an Antecedent of Diabetes App Use 7.1 The Empowerment Approach in Psychology and Management Research
7.1.1 Psychological Empowerment
7.1.2 Behavioral Empowerment
7.1.3 Empowerment as a Motivational Approach
7.1.4 Empowerment and Self-Determination
7.2 Empowerment and its Relevance for Diabetes Self-Management
7.3 Empowerment and Diabetes App Use
7.3.1 Research on Empowerment and Diabetes App Use: Outcome Perspectives
7.3.2 Understanding the Overall Process of Empowerment and Diabetes App Use
7.3.3 Empowerment as an Antecedent of Diabetes App Use 8 Summarizing mHealth Research Gaps II: Empowerment and Diabetes App Use
8.1 Empowerment as a Multi-Dimensional Antecedent of Diabetes App Use
8.2 Two Research Perspectives on Empowerment as an Antecedent of Diabetes App Use
9 Summarizing Model on Empowerment and Diabetes App Use
10 Research Questions and Hypotheses
11 Overview of the Research Design
11.1 mHealth Research on Diabetes App Use in Singapore
11.2 Research Procedure
12 Study 1
Diabetes App Features Corresponding to Indicators of Empowerment: An App Feature and Quality Analysis
12.1 Method
12.1.1 Operationalization

Summary: This book collects and summarizes current scientific knowledge concerning coal-mined landscapes of the Appalachian region in eastern United States. Containing contributions from authors across disciplines, the book addresses topics relevant to the region's coal-mining history and its future; its human communities; and the soils, waters, plants, wildlife, and human-use potentials of Appalachia's coal-mined landscapes. The book provides a comprehensive overview of coal mining's legacy in Appalachia, USA. The book describes the resources of the Appalachian coalfield, its lands and waters, and its human communities - as they have been left in the aftermath of intensive mining, drawing upon peer-reviewed science and other regional data to provide clear and objective descriptions. By understanding the Appalachian experience, officials and planners in other resource extraction- affected world regions can gain knowledge and perspectives that will aid their own efforts to plan and manage for environmental quality and for human welfare. Appalachia's Coal-Mined Landscapes: Resources and Communities in a New Energy Era will be of use to natural resource managers and scientists within Appalachia and in other world regions experiencing widespread mining, researchers with interest in the region's disturbance legacy, and economic and community planners concerned with Appalachia's future.

Contents:
Part 1: Introduction to Appalachian Coalfield Landscape and Resources
Appalachian coalfield landscapes, ecosystems, and economy
Geology and mineral resources
Coal Mining and Reclamation in Appalachia
Part 2: Land
Landscape Alteration
Mine soils
Hydrology
Terrestrial plant communities
Terrestrial wildlife
Management options for mining-affected landscapes
Underground mining
Part 3: Water
Acid drainage: Origins, effects, and treatment
Other water contaminants
Aquatic biota and response to mining
Part 4: Human Ecology of Appalachian Mined Landscapes
Cultural & Economic issues
Human Health
Concluding Chapter: Synthesis.

Summary: This book focuses on interdisciplinary research in the field of biomedical engineering and neuroscience. Biomedical engineering is a vast field, ranging from bioengineering to brain-computer interfaces. The book explores the system-level function and dysfunction of the nervous system from scientific and engineering perspectives. The initial sections introduce readers to the physiology of the brain, and to the biomedical tools needed for diagnostics and effective therapies for various neurodegenerative and regenerative disorders. In turn, the book summarizes the biomedical interventions that are used to understand the neural mechanisms underlying empathy disorders, and reviews recent advances in biomedical engineering for rehabilitation in connection with neurodevelopmental disorders and brain injuries. Lastly, the book discusses innovations in machine learning and artificial intelligence for computer-aided disease diagnosis and treatment, as well as applications of nanotechnology in therapeutic neurology.

Contents:
Module 1_ Introduction to Human Physiology
Module 2_ Neural engineering
Module 3_ Introduction to Neurodegenerative and regenerative Disorders
Module 4_ Brain images and it`s classifications
Module 5_ EEG, EOG and their significance
Module 6_ Artificial Intelligence and Computer Aided diagnosis
Module 7_ Nanomaterials involved in therapeutic strategy
Module 8_ Emotion, Stress and other Neurological dysfunctions
Module 9_ Emotion, Stress and other Neurological dysfunctions.

Contents:
The Era of Big Data: From Data-driven Research to Data-driven Clinical Care
Biostatistics, data mining and computational modeling
Gene expression and profiling
The next generation sequencing and applications in clinical research
Clinical epigenetics and epigenomics
Proteomic profiling: Data mining and analyses
Targeted metabolomics: the next generation of clinical chemistry!?
Clinical bioinformatics for biomarker discovery in targeted metabolomics
Metagenomic Profiling, Interaction of Genomics with Meta-genomics
Clinical Epigenetics and Epigenomics
Integrative Biological Databases
Standards and Regulations for (Bio)Medical Software
Clinical applications and systems biomedicine
Key Law and Policy Considerations for Clinical Bioinformaticians
Challenges and Opportunities in Clinical Bioinformatics
Heterogeneity of Hepatocellular Carcinoma.

Summary: This book provides principles on content analysis and its application into development of nursing theory. It offers clear guidance to students, lecturers and researchers to gain a deeper understanding of the method of content analysis, its implementation into their own research and criteria of trustworthiness evaluation. The book is written in user-friendly language with provided research examples and cases, and the content is illustrated by figures and tables. The authors offer their expertise in providing a well thought through explanation of content analysis in didactical style, which will enhance university education. The book includes highly experienced researchers who have published articles on content analysis and the trustworthiness of the method with more than 10 000 citations. Divided into two parts, this book explores the application of content analysis into nursing science. The first part presents the philosophical position of content analysis, inductive and deductive methods of using content analysis, trustworthiness of the method, and ethical consideration of using content analysis. The second part informs on the theory development based on content analysis, conceptualization of the concepts of content analysis into generation of items and instrument development, and statistical testing of a hypothetical model. The last chapter shows a new approach to using content analysis in systematic reviews and quality evaluation of methodology within systematic review process. The book is an essential tool for nursing science, providing instruction on key methodological elements in order to provide rigorously conducted empirical research for clinical practice and nursing education.

Contents:
PART I. CONTENT ANALYSIS
1. Qualitative research and content analysis
2. Inductive content analysis
3. Deductive content analysis
4. Content analysis in mixed methods research
5. The trustworthiness of content analysis
6. Qualitative research
ethical considerations
PART II. INTEGRATING CONTENT ANALYSIS INTO THEORY DEVELOPMENT
7. Theory development from the results of content analysis
8. Instrument development based on content analysis
9. Statistical testing of a theory
10. Content analysis in systematic review.

Summary: Designed to provide a foundation for nursing informatics knowledge and skills required in today's data-driven healthcare environment, this text examines the impact and implementation of technology in nursing practice. "Application of Nursing Informatics" addresses the foundations of nursing informatics competencies, streamlined for the unique experience of practicing nurses. This text features numerous case scenarios of real-life applications to engage the reader and reinforce content. Chapters cover informatics competencies, knowledge, and skills in a concise manner that recognizes the value of prior nursing experience and builds upon the reader's existing knowledge base. -- From publisher's description.

Contents:
Informatics defined, evolution, guiding principles, expectations / Carolyn Sipes
Roles, professional organizations, and theories / Carolyn Sipes
First things first
hardware / Carolyn Sipes
First things first -software / James Sipes, Carolyn Sipes
Project management / Carolyn Sipes
Application and integration of research into practice / Carolyn Sipes
Applications to support educational initiatives / Taryn Hill, Karen West
Data standardization applications
capturing data / Lisa Blair, Lynda Hardy
Big data applications to inform practice / Lynda Hardy, Lisa Blair
Maintaining quality of data and information, data and data quality / Toni Hebda, Kathleen (Kathy) Hunter
Assessment and evaluating outcomes / Cheryl D. Parker, Melinda Hermanns, and Christy Gibson
Ethics, privacy, security, other technology challenges / Cheryl D. Parker, Christine S. Gipson
Life-long learning : advancing own education / Carolyn Sipes.

Summary: This book looks at health policy through the lens of public versus private: population health versus the somatic, social, or emotional experiences of a patient. Rather than presenting policy/ethics as overly technical, this book takes a novel approach of framing public and private health in terms of political philosophy, ethics, and popular examples. Each chapter ties back to the general ethics or political literature as applicable, which are not customarily parts of the current public health curriculum. The author's work on the Orgcomplexity blog has touched on this subject by systemically exploring public policy issues, and the tone of this book mimics the blog with an extension of the arguments.

Contents:
Introduction
The Justice League of Health: Flexing Policy's Muscle
Health Systems and Policy as the "Price is Right"
Public versus Private: Stop Stepping on My Toes
The Sting of Public Health
Is it Yours, Mine and Ours?
Building on What We've Started
Conclusion. .

Contents:
Rural health disparities: the political economy
Rural health disparities: the economic argument
Social disorganization in rural communities
Political economy in the era of Trump politics
Conclusion : Political economy: an era of institutional cynicism?

Summary: This book focuses on applications of three-dimensional (3D) printing in healthcare. It first describes a range of biomaterials, including their physicochemical and biological properties. It then reviews the current state of the art in bioprinting techniques and the potential application of bioprinting, computer-aided additive manufacturing of cells, tissues, and scaffolds to create organs in regenerative medicine. Further, it discusses the orthopedic applications of 3D printing in the design and fabrication of dental implants, and the use of 3D bioprinting in oral and maxillofacial surgery and in tissue and organ engineering. Lastly, the book examines the 3D printing technologies that are used for the fabrication of the drug delivery system. It also explores the current challenges and the future of 3D bioprinting in medical sciences, as well as the market demand.

Contents:
Chapter 1. Introduction to Biomaterials
Chapter 2. Different approaches used for conversion of biomaterials to feedstock
Chapter 3. Bioprinting
Chapter 4. 3D Printed Implants for Joint Replacement
Chapter 5. Design of Patient-Specific Maxillofacial Implants and Guides
Chapter 6. Design and Development of surgical guide for dental implant surgery
Chapter 7. Three Dimensional printed drugs and related technology : a potential review
Chapter 8. Product Sustainability Assessment
Chapter 9. Successful Stories of 3D Printing in Healthcare Applications: A Brief Review.

Summary: Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various -omics technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.

Contents:
1. Molecular biology of cancer
2. Oncogenomics
3. Sequencing in cancer
4. Oncoproteomics
5. Biomarkers of cancer
6. Molecular diagnosis of cancer
7. Cancer immunotherapy : vaccines
8. Monoclonal antibodies and cancer
9. Nanooncology
10. Cell therapy of cancer
11. Gene therapy of cancer
12. Role of RNAi in cancer
13. Role of microRNAs in cancer
14. Biotechnology in drug discovery and development for cancer
15. Role of biotechnology in drug delivery for cancer
16. Personalized cancer therapy.

Summary: This book provides up-to-date guidance on the use of FDG PET to assess the biological activity and treatment response of a wide range of malignancies, including, for example, lung cancer, breast cancer, head and neck cancer, gastrointestinal cancer, and malignant lymphoma. In the era of precision medicine, numerous new anticancer agents, such as molecular targeted agents and immune checkpoint inhibitors, have been developed to improve outcomes in cancer patients. FDG PET plays a key role in evaluating the effects of these novel treatments because it can detect changes in the metabolic activity of tumors before any reduction in their size is visible on other imaging modalities. Accordingly, FDG PET is of prognostic as well as diagnostic value, and allows prompt changes in patient management. The book is written by expert clinicians from Japan, where the universal public health insurance system ensures that FDG PET is widely used in routine oncological practice and cancer screening. It represents an unrivaled and comprehensive resource that will be of value for all healthcare professionals in the field of clinical oncology.

Contents:
1 Overview.-2 Lung cancer.-3 Breast cancer
4 Head and neck cancer.-5 Gastrointestinal cancer including GIST
6 Pancreatic cancer
7 Urological cancer
8 Malignant bone and soft tissue tumors
9 Skin cancer including malignant melanoma
10 Malignant lymphoma.

Summary: This book presents the applications of ion-exchange materials in the biomedical industries. It includes topics related to the application of ion exchange chromatography in determination, extraction and separation of various compounds such as amino acids, morphine, antibiotics, nucleotides, penicillin and many more. This title is a highly valuable source of knowledge on ion-exchange materials and their applications suitable for postgraduate students and researchers but also to industrial R & D specialists in chemistry, chemical, and biochemical technology. Additionally, this book will provide an in-depth knowledge of ion-exchange column and operations suitable for engineers and industrialists.

Contents:
Separation and Purification of Amino acids
Ion exchange chromatography for enzyme immobilization
Determination of morphine in urine
Chromatographic Separation of Amino Acids
Applications of ion exchange chromatography in pharmaceutical analysis
Thermodynamic Kinetics and Sorption of Bovine Serum Albumin with Different Clay materials
Sorbitol demineralization by ion exchange
Separation and purification of nucleotides, nucleosides, purine and pyrimidine bases by ion exchange
Separation and purification of vitamins: vitamin B1, B2, B6, C, and K1
Colour removal from sugar syrups.

Summary: Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Contents:
Preface
Sustainable Organic Synthesis in Ionic Liquids
Industrial Applications of Green Solvents in Organic and Drug Synthesis for Sustainable Development of Chemical Process and Technologies
Applications of Ionic Liquids in Organic Synthesis
Water-Mediated Catalyst-Free Organic Transformations
Modifications on Polymeric Membranes for Isopropanol Dehydration Using Pervaporation: A Review
Environmentally Benign Organic Synthesis
Green Aspects of Scale-Up Synthesis of some APIs, Drug Candidates Under Development, or Their Critical Intermediates
Green Approaches to Synthesize Organic Compounds and Drugs
Selective Conversion of Glycerol to Lactic Acid Using Porous Multi-Functional Mixed Oxide Catalysts Under Alkaline Environment
Green Biological Synthesis of Nanoparticles and their Biomedical Applications
Silver Nanostructures, Chemical Synthesis Methods, and Biomedical Applications
The Role of Heterogenous Catalysts in Converting Cellulose to Platform Chemicals
Production of Reduced Graphene Oxide (rGO) from Battery Waste: Green and Sustainable Synthesis and Reduction
Bio-Catalysis as a Green Approach for Industrial Waste Treatment
Green Synthesis of Biodiesel Using Microbial Lipases
Industrial Applications of Green Solvents for Sustainable Development of Technologies in Organic Synthesis
Index.

Contents:
Basic Concepts for Statistical Modeling
Introduction to Simple Linear Regression Models
Matrix Representation of the Linear Regression Model
Evaluation of Partial Tests of Hypotheses in a MLRM
Selection of Variables in a Multiple Linear Regression Model
Correlation Analysis
Strategies for Assessing the Adequacy of the Linear Regression Model
Weighted Least-Squares Linear Regression
Generalized Linear Models
Poisson Regression Models for Cohort Studies
Logistic Regression in Case-Control Studies
Regression Models in a Cross-Sectional Study
Solutions to Practice Exercises.

Contents:
The unified protocol for transdiagnostic treatment of emotional disorders : an introduction / Katherine A. Kennedy and David H. Barlow
Transdiagnostic assessment and case formulation : rationale and application with the unified protocol / Hannah Boettcher and Laren R. Conklin
The unified protocol for anxiety disorders / Laren R. Conklin, Todd J Farchione, and Steven Dufour
The unified protocol for obsessive-compulsive and related disorders / Johanna Thompson-Hollands
The unified protocol for major depressive disorder / James F. Boswell, Laren R. Conklin, Jennifer M. Oswald, and Matteo Bugatti
The unified protocol for bipolar and comorbid disorders / Kristen K. Ellard, Emily Bernstein, Andrew A. Nierenberg, and Thilo Deckersbac
The unified protocol for posttraumatic stress disorder / Matthew W. Gallagher
The unified protocol for comorbid alcohol use and anxiety disorders / Todd J Farchione, Tracie M. Goodness, and Katelyn M.E. Williams
The unified protocol for eating disorders / Christina L. Boisseau and James F. Boswell
The unified protocol for insomnia disorder / Jacqueline R. Bullis and Shannon Sauer-Zavala
The unified protocol for nonsuicidal and suicidal self-injury / Kate H. Bentley, Shannon Sauer-Zavala, Clair Cassiello-Robbins, and Stephanie Vento
The unified protocol for borderline personality disorder / Shannon Sauer-Zavala, Kate H. Bentley and Julianne G. Wilner
The unified protocol for chronic pain / Laura A. Payne
The unified protocol for complex, highly comorbid cases / Heather Murray Latin and Clair Cassiello-Robbins
Group treatment applications of the unified protocol / Jacqueline R. Bullis, Kate H. Bentley and Katherine A. Kennedy
Cross-cultural applications of the unified protocol : examples from japan and colombia / Amantia Ametaj, Nina Wong Sarver, Obianujunwa Anakwenze, Masaya Ito, Michel Ratner and Ramya Potluri
The unified protocol : future directions / Clair Cassiello-Robbins, Heather Murray Latin, and Shannon Sauer-Zavala.