BookElena Aikawa, Joshua D. Hutcheson, editors.
Summary: The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.
Contents:
Part I. Cardiovascular Calcification
Chapter 1. The History of Cardiovascular Calcification
Chapter 2. Basic Pathology of Arterial and Valvular Calcification in Humans
Chapter 3. Developmental Pathways and Aortic Valve Calcification
Chapter 4. Differential Mechanisms of Arterial and Valvular Calcification
Chapter 5. Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation
Chapter 6. Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease
Chapter 7. The Role of Chronic Kidney Disease in Ectopic Calcification
Chapter 8. The Role of Calcification in Peripheral Artery Disease
Chapter 9. Bioprosthetic Heart Valve Calcification: Clinicopathologic Correlations, Mechanisms, and Prevention
Part II. Ectopic Calcification
Chapter 10. Electron Microscopy for the Characterization of Soft Tissue Mineralization
Chapter 11. Cardiovascular Calcification in Hutchinson-Gilford Progeria and Correlation with Age-Related Degenerative Calcification
Chapter 12. Calcinosis in Scleroderma
Chapter 13. Placental Calcification: Long-standing Questions and New Biomedical Research Directions
Chapter 14. Heterotopic Ossification Following Traumatic Blast Injury
Part III. Bone Mineralization
Chapter 15. The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization
Chapter 16. Cellular Contributors to Bone Homeostasis
Chapter 17. Bone Biology, Modeling, Remodeling, and Mineralization
Chapter 18. Osteoclasts in Cardiovascular Calcification
Part IV. Imaging, Treatment, and Target Discovery
Chapter 19. Imaging Cardiovascular Calcification Activity with 18F-Fluoride PET
Chapter 20. The Role of Elastin Degradation in Vascular Calcification: Possibilities to Repair Elastin and Reverse Calcification
Chapter 21. Clinical Trials and Calcification-Based Treatment Decisions
Chapter 22. Surgical Versus Transcatheter Aortic Valve Replacement
Chapter 23. Target Discovery in Calcification Through Omics and Systems Approaches