Bookedited by Anders Björklund, M. Angela Cenci.
Contents:
Intro
Recent Advances in Parkinson's Disease
Copyright
Contributors
Contents
Preface: The evolving scenario of Parkinson's research
Part I: Basic Science
Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease
1. Introduction
2. Establishment of iPSC technology and methods of differentiation into DAns
2.1. Establishment of induced pluripotent stem cells
2.2. Differentiation into DAns
3. iPSC-derived neurons for disease modeling
3.1. Endoplasmic reticulum stress
3.2. Protein trafficking and degradation deficits 3.3. Mitochondrial defects and oxidative stress
3.4. Alterations in calcium homeostasis
4. iPSC-derived glial cells for disease modeling
5. Co-culture systems, 3D cultures and organoids for disease modeling
6. iPSC-derived neurons for cell-based treatments
7. Limitations of iPSC-based models
8. Future applications
9. Conclusions
Acknowledgments
References
Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal
1. Introduction
2. Models in different species
3. The importance of nigrostriatal dopaminergic degeneration 4.3. Tertiary and quaternary structure of aSyn
4.4. The effect of PD-associated mutations in aSyn
4.5. Post-translational modifications
5. Alpha-synuclein pathology in the synapse
6. aSyn pathology in mitochondria
7. aSyn pathology in the ER-Golgi compartments
7.1. Degradation and clearance of aSyn
7.2. aSyn pathology and the cytoskeleton
7.3. Effects of aSyn in the nucleus
8. Spreading of aSyn pathology
9. The interplay between aSyn and the microbiome
10. Inflammation
11. Conclusions and outlook
Acknowledgments
References