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  • Book
    Maurice B. Hallett editor.
    Digital : Springer2020
    Intro -- Preface -- Contents -- Contributors -- 1 An Introduction to Phagocytosis -- Introduction to Phagocytosis -- The Cell Biology of Phagocytosis -- Phagocytosis Dissected -- The Importance of Phagocytosis -- Evolution and Phagocytosis -- Introduction to the Chapters in This Book -- 2 A Brief History of Phagocytosis -- Introduction -- Purpose of Chapter -- Let's Start at the Very Beginning -- The Eureka Moment of Metchnikoff -- Inside the Phagocyte -- Phagosomal pH -- Ca2+ Ions and Phagocytosis -- Conclusion -- 3 The Role of Membrane Surface Charge in Phagocytosis -- Introduction Lipids That Contribute to Phagocytosis and Phagosome Maturation -- Phospholipid Dynamics and Inner Leaflet Charge During Phagocytosis and Phagosome Maturation -- Role of Electrostatic Interactions in Protein Localization During Phagocytosis and Phagosome Maturation -- Relevance of Inner Leaflet Surface Charge to Phagocytes and Immunity -- Concluding Remarks -- 4 Receptor Models of Phagocytosis: The Effect of Target Shape -- Introduction -- Why Modelling? -- Receptor Models of Phagocytosis -- The Basic Receptor Model -- Phagocytosis Versus Other Types of Endocytosis -- The Effect of Target Shape Known Experimental Results -- Modelling Shape Dependence -- Model Extensions and the Future -- Summary -- 5 Decision Making in Phagocytosis -- Introduction -- Uptake, Processing, and Release of Long Particles -- Uptake of a Long Particle -- Phagosome Processing -- Release of a Particle -- Myosin-II Does Not Accumulate on the Incipient Phagosome -- Conversion of a Tubular Phagosome into a Bleb -- Simultaneous Uptake and Release of Particles -- Struggle for a Bacterium -- Discussion -- 6 Membrane Tension and the Role of Ezrin During Phagocytosis -- Introduction Apparent Expansion of Cell Surface Area During Phagocytosis -- Exocytotic Addition to the Plasma Membrane -- Cell Surface "Wrinkles" -- Membrane Tension and Cell Shape Changes -- Wrinkles and Membrane Tension -- Molecular Maintenance of Membrane Tension -- Ezrin -- Ezrin and Membrane Tension -- Ezrin and Phagocytosis -- Regulation Membrane Tension by Ezrin During Phagocytosis -- Actin Push and the Brownian Ratchet -- Conclusion and Synthesis -- 7 Molecular Mechanisms of Calcium Signaling During Phagocytosis -- Abbreviations -- Introduction -- Overview of Ca2+ Signaling -- Phagocytic Ca2+ Signals Ca2+-Permeable Channels Involved in Phagocytic Ca2+ Signals -- ORAI Channels, STIM Proteins and Junctate -- TRPC Channels -- TRPC3 -- TRPC4/5 -- TRPC6 -- TRPM Channels -- TRPM2 -- TRPM8 -- TRPML Channels -- TRPV Channels -- TRPV1 and TRPV2 -- TRPV4 -- P2X Channels -- P2X7 -- P2X4 -- Conclusions and Future Directions -- 8 Calpain Activation by Ca2+ and Its Role in Phagocytosis -- Introduction -- Ca2+ in Phagocytosis and Cell Shape Change -- Calpain Activation in Shape Change -- Calpain in Phagocytosis -- Structure of Calpain 1 and 2 -- Physiological Activation of Calpain by Ca2+ in Cells Conclusions