Bookedited by Ji-Yang Wang.
Summary: This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.
Contents:
B cell development and maturation
B cell receptor signalling
Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger
Germinal center reaction
Memory B cells in local and systemic sites
Regulation of plasma cell differentiation
Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor
Regulatory B cells
Diversified IgA-bacteria interaction in gut homeostasis
Primary antibody deficiencies
B cell-mediated autoimmune diseases
B cell lymphomas.