BookTommaso Scarabino, Saverio Pollice, editors.
Summary: This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy and chemotherapy. It features more than 40 clinical cases and 500 illustrations, making it an invaluable clinical and research tool.
Contents:
Intro
Preface
Contents
Part I: Introduction
1: Brain Tumors
1.1 General Findings
1.2 Classification
1.3 2016 World Health Organization Classification of Tumors of the Central Nervous System
1.4 Molecular Markers
1.5 Commentary
1.5.1 Circumscribed Gliomas
1.5.2 Diffuse Infiltrating Gliomas
1.5.3 Astrocytoma/Oligodendgroglioma
1.5.4 Glioblastoma
1.5.5 Ependymoma
1.6 Incidence
1.7 Risk Factors
1.8 Prognostic Factors
1.9 Clinical Presentation
1.10 Diagnostic Investigations
1.11 Surgical Management
1.12 Medical Management
References Part II: Treatment of Gliomas
2: Surgery
2.1 General Findings
2.2 Surgical Treatment: Standard of Care and New Boundaries
2.3 Preoperative Planning
2.4 Surgery
2.5 Tumor Resection: Approaching the Lesion
2.6 Removal of the Mass Lesions: Tips and Tricks
2.7 Intraoperative Tools: Light and Shadows
2.8 Image-Guided Navigation Systems
2.9 Fluorescence-Guided Methods
2.10 High-Grade Gliomas
2.11 Low-Grade Gliomas
2.12 Surgery in Critical Areas
2.13 Recurrent Gliomas
References
3: Radiation Therapy
3.1 General Findings
3.2 Treatment Techniques 3.3 Preparation
3.4 Treatment Planning
3.5 Organs at Risk
3.5.1 Low-Grade Gliomas: Histomolecular Definition
3.6 Role of Radiotherapy (RT)
3.7 Radiation Techniques
3.7.1 Radiation Therapy in High-Grade Gliomas
3.7.2 Reirradiation in High-Grade Glioma
References
4: Chemotherapy Chemotherapy and Future Developments
4.1 General Findings
4.2 Molecular Biology of Gliomas
4.3 Standard of Care for Malignant Low-Grade Glioma
4.4 Standard of Care for Malignant High-Grade Glioma
4.5 Chemotherapy and More
4.6 Role of Bevacizumab
4.7 Future Directions 4.7.1 Growth Factor Receptor Inhibitors
4.7.2 Tumor-Treating Electric Fields for Glioblastoma
4.8 Vaccine Therapy
4.8.1 DC Therapy
4.8.2 Heat Shock Protein (HSP) Vaccines
4.9 Checkpoint Inhibitors
4.10 Chimeric T-Cell Receptors (TCR)
4.11 Viroimmunotherapy
4.12 Conclusions
References
Part III: Post Treatment Neuroradiologic Imaging
5: Magnetic Resonance Technique
5.1 Morphological MRI
5.2 Susceptibility-Weighted Imaging
5.3 Diffusion-Weighted Imaging
5.4 MR Perfusion Imaging
5.5 MR Spectroscopy 5.6 Chemical Exchange Saturation Transfer (CEST): AMID Amide Proton Transfer Imaging
5.7 Diffusion Tensor Imaging
5.7.1 Diffusion Kurtosis Imaging
5.8 Functional MRI
5.9. MRI Molecular Characterization
5.9.1 Codeletion of 1p/19q
5.9.2 Isocitrate Dehydrogenase Mutation
5.9.3 MGMT Promoter Methylation
5.10 Imaging of Treatment Response
5.10.1 Pseudoprogression
5.10.2 Pseudoresponse
5.10.3 Long-Term Complications of Therapy
References
6: Post-surgical MR Morfologic Imaging
6.1 General Findings
6.2 Surgical Approach
6.3 Neuroimaging
References
7: Postradiation Changes in Morphologic MRI