Bookedited by Elisabetta Baldi, Monica Muratori.
Summary: There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
Contents:
Genetic factors affecting sperm chromatin structure
Mechanisms of origin of chromosome deletions and rearrangements in spermatozoa
The sperm epigenome: implications for ART outcomes
Epigenetic transgenerational inheritance
Environmental genetic and epigenetic sperm alterations
Sperm DNA fragmentation: mechanisms of origin
Sperm DNA fragmentation: consequences for reproduction
Oxidative damage to sperm DNA: attack and defence
Interventions to prevent sperm DNA damage effects on reproduction.-Cryopreservation of sperm: effects on chromatin and strategies to prevent them
Effect on sperm DNA quality following sperm selection for ART: new insights
Sperm DNA damage in cancer patients
Index.