BookMitsuo Tagaya, Thomas Simmen, editors.
Summary: "This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future."--Publisher's description.
Contents:
Organelle communication at membrane contact sites (MCS): from curiosity to center stage in cell biology and biomedical research / Thomas Simmen, Mitsuo Tagaya
Over six decades of discovery and characterization of the architecture at mitochondria-associated membranes (MAMS) / Maria Sol Herrera-Cruz, Thomas Simmen
Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane / Mitsuo Tagaya, Kohei Arasaki
Endoplasmic reticulum-mitochondria communication through Ca2+ signaling: the importance of mitochondria-associated membranes (MAMS) / Saverio Marchi, Mart Bittremieux, Sonia Missiroli, Claudia Morganti, Simone Patergnani [and others]
Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites / Kentaro Hanada
Endoplasmic reticulum-plasma membrane crosstalk mediated by the extended synaptotagmins / Yasunori Saheki
Endoplasmic reticulum-plasma membrane contacts regulate cellular excitability / Eamonn J. Dickson
The lipid droplet and the endoplasmic reticulum / Yuki Ohsaki, Kamil Sołtysik, Toyoshi Fujimoto
Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis / Yasushi Tamura, Toshiya Endo
Discovery and roles of ER-endolysosomal contact sites in disease / William Mike Henne
Alzheimer disease / Estela Area-Gomez, Eric A. Schon
Mitochondrial-associated membranes in Parkinson's disease / Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori, Yuzuru Imai
Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes / Jennifer Rieusset
Mitochondrial-endoplasmic reticulum contact sites mediate innate immune responses / Takuma Misawa, Michihiro Takahama, Tatsuya Saitoh
Hepatitis C virus replication / Tetsuro Suzuki
Hijacking of membrane contact sites by intracellular bacterial pathogens / Isabelle Derré
Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer / Martijn Kerkhofs, Carlotta Giorgi, Saverio Marchi, Bruno Seitaj, Jan B. Parys [and others].