Book[edited by] Brigitte Wildemann, Patrick Oschmann, Hansotto Reiber ; with contributions by J. Brettschneider [and others].
Summary: "Up-to-date, comprehensive, and beautifully illustrated, Laboratory Diagnosis in Neurology presents all the measuring parameters and methods relevant to the analysis of cerebrospinal fluid, serum, and tissues affected by neurologic disease and syndromes. Following an introduction to basic concepts, the book guides clinicians through the methods of CSF analysis, neurochemical examinations, clinical applications of neuroimmunology, microbiology and virology, neurogenetic tests, and evaluation of biopsies. Readers will learn about the equipment and various procedures, and how to effectively differentiate similar methods. In the final section of the book, the authors provide a systematic introduction to the pathophysiology and laboratory findings for specific clinical disorders, indications for particular test methods, and criteria for diagnostic interpretation"--Provided by publisher.
Contents:
Cerebrospinal fluid: spaces, production, and flow / H. Reiber
Blood-brain barrier and blood-CSF barrier function / H. Reiber
Blood-brain barrier
The blood-CSF barrier function
Dynamics of serum and brain proteins in CSF and blood / H. Reiber
Serum proteins in CSF
Brain proteins in CSF
Brain proteins in blood
Principles of analytical methods / H. Reiber Immunochemistry
Qualitative electrophoretic methods with or without immunodetection
Immunohistochemistry
Cerebrospinal fluid analysis / B. Storch-Hagenlocher ... [et al.]
Cerebrospinal puncture / B. Storch-Hagenlocher
Measurement of cerebrospinal pressure / B. Storch-Hagenlocher
Cell count, cytology / B. Storch-Hagenlocher Proteins / H. Reiber
Lactate and glucose / H. Reiber
Diagnosis of pathogens / B. Wildemann, H.K. Geiss, P. Schnitzler
Markers of dementia and neuronal destruction / M. Otto
Serum analysis / M. Zorn, M. Uhr
General serum analysis / M. Zorn
Special serum analysis / M. Uhr
Autoantibodies and antineural antibodies / B. Wildemann, U. Wurster
Autoantibodies / B. Wildemann
Antineural antibodies / U. Wurster
Neurogenetics / T. Gasser
Monogenic hereditary neurological disorders
Polygenic or multifactorial hereditary neurological disorders
Biopsy / A. Rosenbohm, A. Sperfeld, H. Tumani
Brain biopsy
Nerve biopsy
Music biopsy
Inflammatory and autoimmune diseases / B. Storch-Hagenlocher, P. Oschmann, B. Wildemann
Infections
Non-pathogen-related inflammatory disorders: autoimmune diseases
Dementia and other psychiatric disorders / M. Otto, M. Uhr
Alzheimer's disease / M. Otto
Lewy body dementia / M. Otto
Frontotemporal lobar degeneration / M. Otto
Multiple system atrophy / M. Otto
Subcortical arteriosclerotic encephalopathy / M. Otto
Creutzfeldt-Jakob disease / M. Otto
Psychiatric disorders / M. Uhr
Cerebral ischemia and hemorrhage / E. Stolz, P. Oschmann
Ischemic cerebral infarction
Intracerebral hemorrhage
Subarachnoid hemorrhage
Cerebral hypoxia
Polyneuropathies / B. Wildemann
Pseudotumor cerebri, ventricular drainage, and neurosurgery / E. Stolz, P. Oschmann
Pseudotumor cerebri
External ventricular drainage, ventriculoatrial and ventriculoperitoneal shunts
Diagnosis of cerebrospinal rhinorrhea and otorrhea
Epileptic seizures / J. Brettschneider, H. Tumani
Brain tumors / B. Storch-Hagenlocher, M. Vogt-Schaden
Primary brain tumors / B. Storch-Hagenlocher
Secondary brain tumors / M. Vogt-Schaden
Neoplastic meaningitis in malignant non-hodgkin lymphoma and leukemia / M. Vogt-Schaden
Metabolic diseases / F. Ebinger
Mitochondrial diseases
Lysosomal diseases
Peroxisomal diseases
Cerebrotendinous xanthomatosis
Leukodystrophy/leukoencephalopathy in organic aciduria
Disorders of copper metabolism
Parasitoses and tropical diseases / H. Reiber, E. Schmutzhard
CSF analysis report / H. Reiber
Integrated CSF report
CSF analysis procedure
Evaluation
Interpretation
Quality assessment in the CSF laboratory / H. Reiber
Quality assessment in laboratory medicine
Internal quality control for CSF proteins (total protein, albumin, IgG, IgA, IgM)
The INSTAND interlaboratory CSF survey
CSF survey : lactate, glucose and surrogate markers
CSF cytology : quality control and interpretation training
Reference ranges of analytes in CSF and serum / H. Reiber
Electrolytes and substrates
Proteins
Amino acides, lipids, and vitamins
Cells.