BookBenjamin Bonavida, editor.
Summary: Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
Contents:
Multidrug Resistance in Cancer: A Tale of ABC Drug Transporters / Khyati Kapoor, Hong May Sim
Multidrug Resistance: A Role for Membrane Physics, pH and Drug Transporters / Chloe Daniel, Cyril Rauch
Mechanisms and Potential Therapies for Acquired Resistance to Inhibitors Targeting the Raf or MEK Kinases in Cancer / Alyson K. Freeman, Deborah K. Morrison
Mechanisms of Resistance to Targeted B-Raf Therapies / Ramana V. Tantravahi, Benjamin Hoffman
Role of β1 Integrins in the Complication and Drug Resistance Against Lung Cancer: Targeting β1 Integrins to Eradicate Lung Cancer / Srirupa Mukhopadhyay, Parth Malik
Aldo-Keto Reductases as New Therapeutic Targets for Colon Cancer Chemoresistance / Toshiyuki Matsunaga, Ossama El-Kabbani
Overcoming Drug Resistance Through Elevation of ROS in Cancer / Amit K. Maiti
Cancer Stem Cells in Resistance to Cytotoxic Drugs: Implications in Chemotherapy / Man-Tzu Wang, Hongmei Jiang, Debasish Boral
Two Birds with a Stone: Molecular Cancer Therapy Targeting Signal Transduction and DNA Repair Pathways / Elisa Zucca, Emmanuele Crespan
Collateral Sensitivity in Drug-Resistant Tumor Cells / Mohamed Saeed, Henry Johannes Greten
Human Cancer Resistance to Trail-Apoptotic Pathway-Targeted Therapies / Anita C. Bellail, Chunhai Hao
The Dark Side of Apoptosis / Malathy P. V. Shekhar.