BookLucas G. Chase, Mohan C. Vemuri, editors.
Summary: Mesenchymal Stem Cells or Multipotent Mesenchymal Stromal Cells (collectively referred to as MSCs) are currently being tested in a number of clinical trials for various diseases including graft-versus-host disease, Crohn's disease, myocardial infarction, stroke, diabetes, cartilage defects, and many others. The increasing number of clinical trials globally indicates the likely therapeutic potential of this specialized adult stem cell. Over the last decade, there has been tremendous progress towards understanding an MSC's phenotype, expansion features in culture, differentiation ability and global gene and protein expression profiles. Despite the enormous progress and data accrual at the molecular and cellular levels, several questions remain as to the utility of MSCs for clinical applications. Mesenchymal Stem Cell Therapy is a comprehensive collection of information comprised of both basic and pre-clinical biological studies as well as current advances in clinical applications within the MSC therapy field. This text is a resource for both the basic life science and cell therapy researchers and includes a spectrum of review chapters from top experts in the field discussing clinical scale culture, regulatory issues, genetic engineering, disease specific applications and others.
Contents:
Scaling-up Ex Vivo Expansion of Mesenchymal Stem/Stromal Cells for Cellular Therapies / F. Dos Santos, P. Z. Andrade, C. L. da Silva
Mesenchymal Stromal Cell Mechanisms of Immunomodulation and Homing / J. Barminko, A. Gray, T. Maguire, R. Schloss
Mesenchymal Stem Cell Exosomes: The Future MSC-Based Therapy? / Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang
The Biology of Mesenchymal Stem Cells in Health and Disease and Its Relevance to MSC-Based Cell Delivery Therapies / Catherine M. Browne, Tung-Liang Chung, Kerry Atkinson
Pulmonary Clinical Applications for Mesenchymal Stem Cells / D. Chambers, P. Hopkins
Stem Cell Therapy for Bone Disorders / Elizabeth Rosado Balmayor, Martijn van Griensven
Mesenchymal Stem Cell Therapies for Bone and Tendon Conditions / Mark Young, Michael R. Doran
Mesenchymal Stromal Cells and the Repair of Cartilage Tissue / Michael R. Doran, Mark Young
Mesenchymal Stem Cells and Haematopoietic Stem Cell Culture / Matthew M. Cook
Mesenchymal Stem Cells for Treatment and Prevention of Graft-Versus-Host Disease and Graft Failure After Hematopoietic Stem Cell Transplantation and Future Challenges / Olle Ringdén M.D., Ph.D.
Mesenchymal Stromal Cell Therapy in Crohn's Disease / Ilse Molendijk, Daan W. Hommes, Marjolijn Duijvestein
Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis / Josep Gamez M.D., Ph.D.
Mesenchymal Stem Cell Therapy for Heart Disease / Massimiliano Gnecchi, Elisabetta Cervio
Advances in Lentiviral Vector-based Cell Therapy with Mesenchymal Stem Cells / Lajos Baranyi, Boro Dropulic
Genetically Engineered Mesenchymal Stem Cells for Cell and Gene Therapy / Yunjoon Jung, Jan A. Nolta Ph.D.
Optimal Tissue Sources of Mesenchymal Stromal Cells for Clinical Applications / Celena Heazlewood, Kerry Atkinson
Regulatory Considerations Applicable to Manufacturing of Human Placenta-Derived Mesenchymal Stromal Cells (MSC) Used in Clinical Trials in Australia and Comparison to USA and European Regulatory Frameworks / Nina Ilic, Dalia Khalil, Sonia Hancock, Kerry Atkinson
Mesenchymal Stem Cell Therapy for Peripheral Vascular Diseases / Anjan K. Das, Pawan K. Gupta, C. H. Anoop
Mesenchymal Stromal Cells in the Clinic: What Do the Clinical Trials Say? / Vivek Tanavde, Mohan C. Vemuri.