BookBohuslav Ostadal, Naranjan S. Dhalla, editors.
Summary: The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to [alpha]-adrenoceptor and [beta]-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
Contents:
Comparative Aspects of Cardiac Adaptation
Molecular Mechanisms in Cardiac Development
Prenatal Adaptation to Overload
Hypoxia and Mechanical Factors Drive Coronary Vascular Development
Cardiac Metabolic Adaptation During Postnatal Development
Ontogenetic Adaptation to Chronic Hypoxia
Heart and Arterial Aging
Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy
Cardiac Adaptation to Volume Overload
Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females
Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations
Cardiopulmonary Adaptation to High Altitude
Cardiac Hypertrophy in Hypertension
Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice
The Athlete's Heart
Role of [beta]
Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy
Role of Phospholipase C in the [alpha]1
Adrenoceptor Mediated Cardiac Hypertrophy
Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart
Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy
Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection
Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor
Myocardial Adaptation and Autophagy
Modulatory Role of VEGF in Angiogenesis for Cell Survival
The Role of CaM Kinase II in Cardiac Function in Health and Disease