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  • Book
    Marta Filizola, editor.
    Summary: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.--Back cover.

    Contents:
    Pt. I. Progress in structural modeling of GPCRs
    The GPCR crystallography boom: providing an invaluable source of structural information and expanding the scope of homology modeling
    Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes
    Pt. II. GPCRs in motion: insights from simulations
    Structure and dynamics of G-protein coupled receptors
    How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment
    Coarse-grained molecular dynamics provides insights into the interactions of lipids and cholesterol with rhodopsin
    Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods
    Pt. III. GPCR-focused design and mathematical modeling
    From three-dimensional GPCR structure to rational ligand discovery
    Mathematical modeling of G protein-coupled receptor function: what can we learn from empirical and mechanistic models?
    Pt. IV. Bioinformatics tools and resources for GPCRs
    GPCR & company: databases and servers for GPCRs and interacting partners
    Bioinformatics tools for predicting GPCR gene functions.
    Digital Access Springer 2014