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  • Book
    edited by P. Michael Conn.
    Summary: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

    Contents:
    1. Expression of GPCRs in Pichia pastoris for structural studies / Christoph Krettler, Christoph Reinhart, Carville G. Bevans
    2. Conformational ensemble view of G protein-couples receptors and the effect of mutations and ligand binding / Ravinder Abrol, Soo-Kyung Kim, Jenelle K. Bray, Bartosz Trzaskowski, William A. Goddard III
    Structural evolution of G-protein-coupled receptors: a sequence space approach / Jean-Michel Bécu, Julien Pelé, Patrice Rodien, Hervé Abdi, Marie Chabbert
    4. Directed evolution of G-protein-coupled receptors for high functional expression and detergent stability / Karola M. Schlinkmann, Andreas Plückthun
    5. The Role of hydrophobic amino acids in the structure and function of the Rhodopsin family of G protein-coupled receptors / Gianluigi Caltabiano, Angel Gonzalez, Arnau Cordomí, Mercedes Campillo, Leonardo Pardo
    6. Structure of [beta]-adrenergic receptors / Florian Brueckner, Chayne L. Piscitelli, Ching-Ju Tsai, Jörg Standfuss, Xavier Deupi, Gebhard F.X. Schertler
    7. Advances in methods to characterize ligand-induced ionic lock and Rotamer toggle molecular switch in G protein-coupled receptors / Xiang-Qun Xie, Ananda Chowdhury
    8. Crystallogenesis of adenosine A2A receptor-T4 lysozyme fusion protein: a practical route for the structure / Yashwanth Ashok, Rahul T. Nanekar, Veli-Pekka Jaakola
    9. Probing GPCR structure: adenosine and P2Y nucleotide receptors / Kenneth A. Jacobson, Stefano Costanzi, Francesca Deflorian
    10. Strategies for studying the ligand binding site of GPCRs: photoaffinity labeling of the VPAC1 receptor, a prototype of class B GPCRs / Alain Couvineau, Yossan-Var Tan, Emilie Ceraudo, Marc Laburthe
    11. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans / Beata Jastrzebska, David Salom, Hui Jin, Pengxiu Cao, Wenyu Sun, Krzysztof Palczewski, Zhaoyang Feng
    12. Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors / Angela Seebahn, Heinrich Sticht, Ralf Enz
    13. Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling / Thomas Huber, Saranga Naganathan, He Tian, Shixin Ye, Thomas P. Sakmar
    14. Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers / Amy Grunbeck, Thomas Huber, Thomas P. Sakmar
    15. Alternative mRNA splicing of G protein-coupled receptors / Danijela Markovic
    16. Functional residues essential for the activation of the C1 Cannabinoid receptor / Joong-Youn Shim, Lea Padgett.
    Digital Access ScienceDirect 2013