Bookedited by Zahid H. Siddik.
Contents:
1. Circuitry of Checkpoint Response
Evasion of G1 Checkpoints in Cancer
Distinct Pathways Involved in S-Phase Checkpoint Control
Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response
2. Checkpoint Response and the Aetiology of Cancer
Chromatin Modifications and Orchestration of Checkpoint Response in Cancer
DNA Damage Response and the Balance Between Cell Survival and Cell Death
Dysfunction of the RB Retinoblastoma Gene in Cancer
G1 Phase Cyclins in Cancer Development and Progression
The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls
3. Targeting Checkpoint Response in Cancer Therapy
Regulation of p53 Activity and Associated Checkpoint Controls
The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors
Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy
p27Kip1 as a Biomarker and Target for Treatment of Cancer
Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors
Chk1 and Chk2 as Checkpoint Targets
Targeting Cdc25 Phosphatases in Cancer Therapy.