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  • Book
    edited by Zahid H. Siddik.
    Contents:
    1. Circuitry of Checkpoint Response
    Evasion of G1 Checkpoints in Cancer
    Distinct Pathways Involved in S-Phase Checkpoint Control
    Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response
    2. Checkpoint Response and the Aetiology of Cancer
    Chromatin Modifications and Orchestration of Checkpoint Response in Cancer
    DNA Damage Response and the Balance Between Cell Survival and Cell Death
    Dysfunction of the RB Retinoblastoma Gene in Cancer
    G1 Phase Cyclins in Cancer Development and Progression
    The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls
    3. Targeting Checkpoint Response in Cancer Therapy
    Regulation of p53 Activity and Associated Checkpoint Controls
    The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors
    Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy
    p27Kip1 as a Biomarker and Target for Treatment of Cancer
    Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors
    Chk1 and Chk2 as Checkpoint Targets
    Targeting Cdc25 Phosphatases in Cancer Therapy.
    Digital Access Springer 2010