Immunology & Rheumatology
Journals
E-Books
Multimedia/ Videos
- Clinical Evaluation of the Knee
- Arthrocentesis of the Knee
- Brief Exam for Skeletal Injuries
- Examination of the Appendicular Skeleton. Part 1, Examination of the Lower Limb
- Examination of the Appendicular Skeleton. Part 2, Examination of the Upper Limb
- Examination of the Axial Skeleton
- Detailed Examination of the Head and Neck. Part 1, Skull, Scalp, Face, TMJ and Salivary Glands
- The Knee Exam
- Posterior Leg Splint
- Skin and Nails
Guidelines/ Diagnostic criteria/ Management
ACR practice guidelines
NICE practice guidelines
EULAR recommendations for management
- Systemic Lupus Erytematosus
- Systemic Lupus Erythematosus With Neuropsychiatric Manifestations
- Lupus Nephritis
- Psoriatic Arthritis
- Ankylosing Spondylitis
- Management Of Ankylosing Spondylitis - The Patient Version
- Anklyosing Spondylitis: A Systematic Literature Review
- Calcium Pyrophosphate Disease
- Vaccination In Adult Patients With Autoimmune Inflammatory Rheumatic Diseases
- Rheumatoid Arthritis With Synthetic And Biological Disease-Modifying Antirheumatic Drugs
- Cardiovascular Risk Management In Patients With Rheumatoid Arthritis And Other Forms Of Inflammatory Arthritis
- Systemic Glucocorticoid Therapy In Rheumatic Diseases
- Systemic Glucocorticoid Therapy In Rheumatic Diseases Pt 2
- Treatment Of Systemic Sclerosis: A Report From The Eular Scleroderma Trials And Research Group (Eustar)
- Behçet Disease
- Fibromyalgia Syndrome
- Hand Osteoarthritis
- Gout
- Early Arthritis
- Hip Osteoarthritis
- Knee Osteoarthritis
ACR - endorsed criteria
- Sjogren's Syndrome
- PMR
- Rheumatoid Arthritis
- Childhood Arthritis Definition of Improvement
- Churg-Strauss Syndrome
- Fibromyalgia
- Giant Cell (Temporal) Arteritis
- Henoch-Schoenlein Purpura
- Hypersensitivity Vasculitis
- Osteoarthritis- Hand
- Osteoarthritis- Hip
- Osteoarthritis- Knee
- Polyarteritis Nodosa
- Systemic Sclerosis
- SLE
- Takayasu Arteritis
- Wegener'S Granulomatosis- Granulomatosis With Polyangiitis
EULAR classification and diagnosis criteria/ response criteria
Recommended Reading & Guidelines
- A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. N Engl J Med, 1991. 324(3): p. 150-4.
- Alarcon, G.S., et al., Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L). Ann Rheum Dis, 2007. 66(9): p. 1168-72.
- American College of Rheumatology, New NOF Guidelines and the WHO Fracture Assessment Tool or FRAX. 2008.
- American College of Rheumatology, Osteoporosis and Bone Mineral Density - American College of Rheumatology. 2016.
- Appel, G.B., et al., Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J Am Soc Nephrol, 2009. 20(5): p. 1103-12.
- Cummings, S.R., et al., Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med, 2009. 361(8): p. 756-65.
- Erkan, D., G. Espinosa, and R. Cervera, Catastrophic antiphospholipid syndrome: updated diagnostic algorithms. Autoimmun Rev, 2010. 10(2): p. 74-9.
- Fam, A.G., Paraneoplastic rheumatic syndromes. Baillieres Best Pract Res Clin Rheumatol, 2000. 14(3): p. 515-33.
- Ginzler, E.M., et al., Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial. Arthritis Rheum, 2010. 62(1): p. 211-21.
- Houssiau, F.A., et al., Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum, 2002. 46(8): p. 2121-31.
- Manzi, S., et al., Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials. Ann Rheum Dis, 2012. 71(11): p. 1833-8.
- Merrill, J.T., et al., The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial. Arthritis Rheum, 2010. 62(10): p. 3077-87.
- Miyakis, S., et al., International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost, 2006. 4(2): p. 295-306.
- National Institute of Environmental Health Sciences, IMACS FORM 07A: MYOSITIS DISEASE ACTIVITY. 2005.
- National Institute of Environmental Health Sciences, MANUAL MUSCLE TESTING PROCEDURES for MMT8 TESTING. 2007.
- Petri, M., et al., Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med, 2005. 353(24): p. 2550-8.
- Petri, M., et al., Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum, 2012. 64(8): p. 2677-86.
- Stone, J.H., et al., Mechanisms of Disease: IgG4-related disease. N Engl J Med, 2012. 366(6): p. 539-51.
- Weening, J.J., et al., The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int, 2004. 65(2): p. 521-30.
Recent Articles
Arthritis & Rheumatism
- The regional distribution of rheumatologists: what can we do, what should we do?
- Regional distribution of adult rheumatologists.
- Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome.
- Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.
- Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
- Splitting headache (off).
- 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative.
- Dysregulation of Treg cells in antineutrophil cytoplasmic antibody-associated vasculitis: comment on the article by Free et al.
- Reply: To PMID 23553415.
- 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications.
- Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. San Diego, California, USA.
- Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ.
- Role of interleukin-10 in endochondral bone formation in mice: anabolic effect via the bone morphogenetic protein/Smad pathway.
- Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.
- M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.
- Prevalence of the fibromyalgia phenotype in patients with spine pain presenting to a tertiary care pain clinic and the potential treatment implications.
- Indocyanine green-enhanced fluorescence optical imaging in patients with early and very early arthritis: a comparative study with magnetic resonance imaging.
- P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway.
- A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium.
- Recommendations for screening and detection of connective tissue disease-associated pulmonary arterial hypertension.
- MicroRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1β-induced catabolic effects in human chondrocytes.
- Controversial correlation between Fcγ receptor IIB and Toll-like receptor 2 in rheumatoid arthritis: comment on the article by Abdollahi-Roodsaz et al.
- Reply: To PMID 23860661.
- Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a Treg cell-deficient milieu.
- Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.
- Annexin A6 interacts with p65 and stimulates NF-κB activity and catabolic events in articular chondrocytes.
- Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts.
- Tumor necrosis factor α inhibition in radiographic and nonradiographic axial spondyloarthritis: results from a large observational cohort.
- Progressing toward, and recovering from, knee replacement surgery: a five-year cohort study.
- 9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus.
- Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.
- Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.
- A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.
- Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome.
- Clinical images: Bronchial stenosis in granulomatosis with polyangiitis (Wegener's).
- Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo.
- Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis.
- Value of isolated IgA anti-β2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome.
- The peroxisome proliferator-activated receptor γ agonist pioglitazone preserves bone microarchitecture in experimental arthritis by reducing the interleukin-17-dependent osteoclastogenic pathway.
- Role of Fms-like tyrosine kinase 3 ligand as a potential biologic marker of lymphoma in primary Sjögren's syndrome.
- Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis.
- Memory dysfunction in primary Sjögren's syndrome is associated with anti-NR2 antibodies.
- Pregnancy and Behçet's disease: comment on the article by Noel et al.
- Reply: To PMID 23780828.
- Chronic kidney disease and the risk of incident gout among middle-aged men: a seven-year prospective observational study.
- Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.
- Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice.
- Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain.
- Clinical image: Linear branching depigmentation of the leg.
- Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.
- The percentage of FoxP3+Helios+ Treg cells correlates positively with disease activity in systemic lupus erythematosus.
- Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.
- Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.
- Clinical images: enchondromatosis (Ollier disease).
- Periarticular bone loss in antigen-induced arthritis.
- Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents.
- Ethnic-specific genetic analyses in rheumatoid arthritis: incremental gains but valuable contributions to the big picture.
- A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians.
- ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling.
- Rituximab-induced T cell depletion in patients with rheumatoid arthritis: association with clinical response.
- Association of paraoxonase 1 gene polymorphism and enzyme activity with carotid plaque in rheumatoid arthritis.
- ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.
- Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis.
- Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect.
- Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age.
- Family studies in the information age.
- Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CX₃ CL1 in rheumatoid arthritis.
- Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis.
- Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus.
- Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection.
- Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression.
- Clinical images: osteoporotic calcaneal stress fractures mistaken for aggravation of rheumatoid arthritis.
- The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis.
- Motion for debate: osteoarthritis clinical trials have not identified efficacious therapies because traditional imaging outcome measures are inadequate.
- Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB.
- Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis.
- Review: the utility of magnetic resonance imaging for assessing structural damage in randomized controlled trials in rheumatoid arthritis.
- Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists.
- Metabolic profiling reveals differences in concentrations of oxylipins and fatty acids secreted by the infrapatellar fat pad of donors with end-stage osteoarthritis and normal donors.
- Sweets are good for you: fine tuning antibodies via glycosylation.
- Ethics, professionalism, and rheumatology.
- Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
- Ethical challenges in rheumatology: a survey of the American College of Rheumatology membership.
- RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.
- Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2.
- Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus.
- High body mass index is associated with increased diurnal strains in the articular cartilage of the knee.
- Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.
- Brief report: the IL23R nonsynonymous polymorphism rs11209026 is associated with radiographic sacroiliitis in spondyloarthritis.
- Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.
- Brief report: deficient thymic output in rheumatoid arthritis despite abundance of prethymic progenitors.
- Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis.
- Brief report: accelerated aging influences cardiovascular disease risk in rheumatoid arthritis.
- The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis.
- Spinal gout presenting as acute low back pain.
- Anti-tumor necrosis factor and new bone formation in ankylosing spondylitis: the controversy continues.
- Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis.
- Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease.
- Unique protein signature of circulating microparticles in systemic lupus erythematosus.
- Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis.
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