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SHC Antibiogram: Staphylococci

Percent Susceptible by Broth Microdilution

  No. Tested Peni-
cillin (a)
Naf-
cillin, Oxa- cillin (b, c)
1st Gener-
ation Cephems (c)
Vanco-
mycin
Erythro-
mycin
Clinda-
mycin (d)
Genta-
micin
Trimeth/ Sulfa Moxi-
floxacin
Tetra-
cycline (Doxy)
Line-
zolid
Staphylococcus aureus, ALL(b) 1003 12% 64% 64% 100% 50% 79% 97% 99% 64% 95% 100%
 MRSA (ONLY) (c) 349 0% 0% 0% 100% 5% 49% 96% 100% 21% 96% 100%
Staph. epidermidis 25 12% 32% 32% 100% 41% 55% 56% 36% - - -
Staph. lugdunensis 19 84% 95% 95% 100% 100% 100% 100% 100% - - 100%
Staph. coagulase negative (other) 226 12% 30% 30% 100% 37% 62% 69% 61% 40% - 100%
Cost ($)   $ $ $ $ $ $$ $ $ $$ $ $$$

(a) Penicillin-resistant staphylococci should be considered resistant to all penicillinase- sensitive penicillins, including ampicillin, amoxicillin, mezlocillin, piperacillin and ticarcillin.
(b) For empiric therapy where S. aureus is a potential pathogen, nafcillin and first generation cephalosporins are recommended drugs of choice for infections other than serious or systemic, for which vancomycin should be used until the susceptibility results are available. (c) Oxacillin resistant staphylococci (MRSA & MRSE) should be considered resistant to all penicillins, cephalosporins, imipenem and beta-lactams including combinations with clavulanic acid, sulbactam and tazobactam. Oxacillin susceptibility predicts susceptibility to all other beta-lactams. (d) Clindamycin induction test not performed on all staphylococcal isolates.

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