For infections with β-lactamase-producing H. influenzae: cefuroxime, cefotaxime, trimethoprim/ sulfamethoxazole, amoxicillin/clavulanate or azithromycin is recommended. Cefotaxime or ceftriaxone is drug of choice for CNS infections. At Stanford, 73% of H. influenzae are ampicillin susceptible.