SHC Antibiogram: Gram Negative Rods 2008 (a)

• SHC Antibiogram 2008   (printable PDF)

Percent Susceptible by Broth Microdilution

	PENICILLINS					CEPHEMS			LACTAMS			AMINOGLYC's			OTHERS			Urine Only
	No. Test- ed	Ampi- cillin	Pipera- cillin	Amp/ Sul- bac- tam	Pip/ Tazo- bac- tam	Cefa- zolin	Cefo- taxime	Cefe- pime	Aztreo- nam (c)	Imi- penem	Mero- penem	Genta- micin	Tobra- mycin	Amik- acin	Cipro- flox- acin	Levo- flox- acin	Tri- meth/ Sulfa- meth- ox	1ST GENER- ATION Ceph's [oral]	Nitro- furan- toin
Achro- mobacter xylosoxidans	21	-	-	-	80%	-	-	0%	0%	95%	85%	0%	0%	0%	0%	45%	85%	-	-
Acinetobacter baumannii	28	-	-	82%	-	-	-	59%	-	-	89%	78%	89%	89%	70%	74%	82%	-	-
Burkholderia cepacia (d,e)	7	Ceftazidime 83%				-	Minocycline 83%			-	67%	-	-	-	-	-	100%	-	-
Citrobacter freundii	41	37%	-	74%	74%	5%	82%	100%	85%	100%	100%	95%	93%	100%	90%	93%	81%	-	96%
Citrobacter koseri	34	0%	-	100%	100%	97%	100%	100%	100%	100%	100%	100%	100%	100%	100%	100%	94%	-	64%
Enterobacter aerogenes	60	3%	-	49%	90%	20%	86%	98%	90%	100%	100%	100%	100%	100%	100%	100%	98%	-	13%
Enterobacter cloacae	96	7%	-	20%	90%	1%	79%	95%	84%	100%	100%	96%	99%	100%	94%	96%	88%	-	27%
Escherichia coli	1300	52%	-	61%	98%	87%	91%	95%	94%	100%	100%	88%	88%	100%	77%	77%	71%	22%	96%
Klebsiella oxytoca	67	6%	-	72%	99%	58%	95%	99%	97%	100%	100%	100%	99%	100%	99%	99%	99%	-	72%
Klebsiella pneumoniae	294	0%	-	85%	98%	95%	95%	97%	96%	100%	100%	98%	97%	99%	93%	94%	85%	100%	20%
Morganella morganii	32	0%	-	9%	94%	0%	100%	100%	97%	-	-	84%	91%	100%	84%	-	74%	-	0%
Proteus mirabilis	108	82%	-	93%	100%	94%	96%	99%	99%	-	-	94%	96%	100%	89%	-	80%	-	0%
Proteus vulgaris	10	0%	-	100%	100%	0%	-	100%	100%	100%	100%	100%	100%	100%	100%	100%	80%	-	0%
Pseudomonas aeruginosa	512(f)	-	-	-	94%	-	-	82%	71%	87%	88%	81%	89%	94%	71%	68%	-	-	-
Ps. aeruginosa CF mucoid (e)	163(f)	-	79%	Ticarcillin 73%			-	83%	70%	73%	85%	-	82%	-	58%	-	-	-	-
Ps. aeruginosa CF non-mucoid (e)	91(f)	-	60%	Ticarcillin 55%			-	52%	48%	57%	63%	-	50%	-	33%	-	-	-	-
Salmonella spp. (g)	14	86%	-	-	-	Ceftriaxone 100%		-	-	-	-	-	-	-	100%	-	100%	-	-
Serratia marcescens	59	7%	-	9%	93%	0%	89%	100%	91%	100%	100%	98%	95%	100%	97%	98%	100%	-	-
Steno- trophomonas maltophilia	65	-	-	Ticarcillin/ Clavulanate 46%				-	Levofloxacin 89%		-	-	-	-	-	-	98%	-	-
Cost		$	$$$	$$	$$$	$	$$	$$	$$$	$$$	$$$	$	$	$$	$$	$$	$	$	$

(a) Until final identifications are available, reports describe gram negative rods as lactose-fermenters (LF; such as E.coli, Klebsiella, Enterobacter, Citrobacter); non-lactose fermenters (NLF, such as Proteus, Serratia, Salmonella, Shigella), or non-fermenters (NF, such as Pseudomonas, Acinetobacter, Stenotrophomonas, and others, most of which are intrinsically more resistant to many antibiotics).

(b) Not all isolates tested against every antibiotic listed.

(c) Unlike aztreonam, aminoglycosides have synergistic activity with β-lactams (ex: piperacillin, ampicillin) against aerobic gram negative rods and enterococci. Aztreonam should only be used for treating documented infections due to susceptible organisms in patients with anaphylactic reactions to β-lactams. In patients with renal insufficiency, aminoglycosides can be administered safely when doses are adjusted for patient’s renal function. For information on dosing, including single daily dosing, please contact a Clinical Pharmacist (beeper # available from unit secretary).

(d) Data from isolate totals < 10 may be statistically unreliable.

(e) Cystic fibrosis patient isolates tested by disk diffusion.

(f) Pseudomonas aeruginosa isolates not corrected for duplicates.

(g) Infectious Diseases consultation strongly recommended for determining treatment of Salmonella sp. recovered from blood.