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ToxicologyAccess restricted to Stanford unless otherwise noted

  • This book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity. Fills a gap in the toxinological, medical and herpetological literature by providing a comprehensive review of this entire assemblage of snakes, with particular attention given to their capacity, real or rumored, to cause harm to humans A patient-centered, evidence-based approach is applied to analyzing documented case reports of bites inflicted by approximately 100 species. Clinical management of medically significant bites from non-front-fanged colubroids is methodically reviewed, and specific recommendations are provided.
  • pt. 1. Formation and analysis of hazardous compounds in heat-treated foods -- pt. 2. Health risks of acrylamide and other hazardous compounds in heat-treated foods -- pt. 3. Minimising the formation of hazardous compounds in foods during heat treatment.
  • "The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • A. Engineered nanomaterials: hazard, exposure and safety assessment. Interactions with the human body / Renato Colognato ... [et al.] -- Exposure assessment / Antonio Bergamaschi, Ivo Iavicoli and Kai Savolainen -- Biomonitoring / Enrico bergamaschi and Andrea Magrini -- Critical evaluation of toxicity tests / Maria Dusinska ... [et al.] -- Computational approaches / Vidana Epa, Dave Winkler and Lang Tran -- Regulation and legislation / Maureen R. Gwinn and Birgit Sokull-Klüttgen -- B. Engineered nanomaterials: impact on human health. Respiratory system / Ken Donaldson and Craig Poland -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills and Rodger Duffin -- Neurological system / Sandra Ceccatelli and Giuseppe Bardi -- Immune system / Diana Boraschi and Albert Duschl -- Skin / Nancy A. Monteiro-Riviere and Francesca Larese Filon -- Gastrointestinal tract / Mark A. Jepson -- Reproductive toxicity / Karin Sørig Hougaard and Luisa Campagnolo -- Genotocicity and cancer / Shareen H. Doak, Ying Liu and Chunying Chen -- C. Biomedical applications of engineered nanomaterials. Diagnostic applications / Kalcheng and Zhen Cheng -- Therapeutic applications / Cyrill Bussy ... [et al.] -- Annex: synthesis of engineered nanomaterials / Muhammet S. toprak, Gulaim A. Seisenbaeva and Vadim G. Kessler.
  • Aflatoxin and food safety 2005, CRCnetBASE
  • Allelopathy 2006, Springer
    General -- Methodological aspects -- Physiological aspects of allelopathy -- Ecophysiology and allelopathy -- Ecological aspects of allelopathy -- Allelopathy in different environments -- Applied aspects of allelopathy.
  • Pesticides: classification and properties / José L. Tadeo, Consuelo Sánchez-Brunete, Lorena González -- Sample handling of pesticides in food and environmental samples / Esther Turiel, Antonio Martín-Esteban -- Analysis of pesticides by chromatographic techniques coupled with mass spectrometry / Simon Hird -- Immunoassays and biosensors / Jeanette M. Van Emon ... [et al.] -- Quality assurance / Árpád Ambrus -- Determination of pesticides in food of vegetal origin / Frank J. Schenck, Jon W. Wong -- Determination of pesticides in food of animal origin / Antonia Garrido Frenich, Jose Luis Martinez, Adrian Covaci -- Determination of pesticides in soil / Consuelo Sánchez-Brunete, Beatriz Albero, José L. Tadeo -- Determination of pesticides in water / Jay Gan, Svetlana Bondarenko -- Sampling and analysis of pesticides in the atmosphere / Maurice Millet -- Levels of pesticides in food and food safety aspects / Kit Granby ... [et al.] -- Monitoring of pesticides in the environment / Ioannus Konstantinou ... [et al.].
  • Drug incorporation into hair / Robert Kronstrand and Karen Scott -- Passive exposure, decontamination procedures, cutoffs, and bias: pitfalls in the interpretation of hair analysis results for cocaine use / David A. Kidwell and Frederick P. Smith -- Opioids testing in hair / Michel Yegles and Robert Wennig -- Hair analysis for cocaine / Carmen Jurado -- Determination of cannabinoids in human hair / Michael Uhl -- Amphetamine determination in hair / Vincent Cirimele -- Pharmaceuticals in hair / Marjorie Cheze, Marc Deveaux, Gaelle Duffort, Francis Billault, and Gilbert Pepin -- Screening strategies in hair analysis on drugs / Hans Sachs -- Clinical applications of hair analysis / Simona Pichini, Oscar Garcia-Algar, and Rafael de la Torre -- Hair in postmortem toxicology / Robert Kronstrand and Henrik Druid -- Detection of doping agents in human hair / Pascal Kintz -- Applications of hair in drug-facilitated crime evidence / Marion Villain -- Application of hair in driving-license regranting / Manfred R. Moeller, Hans Sachs, and Fritz Pragst -- Alcohol markers in hair / Fritz Pragst and Michel Yegles -- Workplace drug testing using hair samples / Thomas Cairns, Michael Schaffer, and Virginia Hill -- Metals / Jean-Pierre Goulle.
  • Animal hematotoxicology 2008, CRCnetBASE
    Hemopoiesis, blood cell types, and bone marrow examination -- Erythrocytes, anemias, and polycythemia -- Additional erythrocytic measurements -- Iron, associated proteins, and vitamins -- Leukocytes -- Immunotoxicology -- Hemostasis -- Pre-analytical variables -- Analytical variables and biosafety -- Data processing and interpretation.
  • The mouse -- The rat -- The hamster -- The guinea pig -- The rabbit -- The ferret -- The dog -- Primates -- The minipig -- Alternative species / Shayne C. Gad -- Clinical pathology of laboratory animals / Robert L. Hall -- Model selection and scaling / Shayne C. Gad -- Susceptibility factors / Shayne C. Gad -- Laws and regulations governing animal care and use in research / Shayne C. Gad.
  • Asbestos 2005, CRCnetBASE
  • Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
  • "This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years."--Publisher's website.
  • Biodefense 2006, CRCnetBASE
  • This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed --source other than Library of Congress.
  • Cancer immunotherapy 2013, Springer
    This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
  • Carbon monoxide poisoning 2008, CRCnetBASE
  • Carbon nanotubes 2008, CRCnetBASE
  • Print Material
    Unit I: General principles of toxicology -- History and scope of toxicology / Michael A. Gallo -- Principles of toxicology / David L. Eaton and Steven G. Gilbert -- Mechanisms of toxicity / Zoltán Gregus -- Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Unit II: Disposition of toxicants -- Absorption, Distribution, and excretion of toxicants / Lois D. Lehman-McKeeman -- Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie -- Toxicokinetics / Danny D. Shen -- Unit III: Non-organ-directed toxicity -- Chemical carcinogens / James E. Klaunig and Lisa M. Kamendulis -- Genetic toxicology / R. Julian Preston and George R. Hoffmann -- Developmental toxicology / John M. Rogers and Robert J. Kavlock -- Unit IV: Target organ toxicity -- Toxic responses of the blood / John C. Bloom and John T. Brandt -- Toxic responses of the immune system / Norbert E. Kaminski ... [et al.] -- Toxic responses of the liver / Hartmut Jaeschke -- Toxic responses of the kidney / Rick G. Schnellmann -- Toxic responses of the respiratory system / Hanspeter R. Witschi ... [et al.] -- Toxic responses of the nervous system / Virginia C. Moser ... [et al.] -- Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes -- Toxic responses of the heart and vascular system / Y. James Kang -- Toxic responses of the skin / Robert H. Rice and Theodora M. Mauro -- Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray Jr. -- Toxic responses of the endocrine system / Charles C. Capen -- Unit V: Toxic agents -- Toxic effects of pesticides / Lucio G. Costa -- Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes -- Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand, and D. Alan Warren -- Health effects of radiation and radioactive materials / Naomi H. Harley -- Properties and toxicities of animal venoms / John B. Watkins, III -- Toxic effects of plants / Stata Norton -- Unit VI: Environmental toxicology -- Air pollution / Daniel L. Costa -- Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Unit VII: Applications of toxicology -- Food toxicology / Frank N. Kotsonis and George A. Burdock -- Analytic/forensic toxicology / Alphonse Poklis -- Clinical toxicology / Louis R. Cantilena Jr. -- Occupational toxicology / Peter S. Thorne.
  • pt. 1. Regulation and quality control of chemical migration into food -- pt. 2. Assessing the risks and improving the safety of food contact materials -- pt. 3. Chemical migration from particular food contact materials.
  • Chemical pesticides 2004, CRCnetBASE
  • Brief history and use of chemical warfare agents in warfare and terrorism / Harry Salem, Andrew L. Ternay, Jr., and Jeffery K. Smart -- The chemistry of chemical warfare agents / Peter Kikilo, Vitaly Fedorenko, and Andrew L. Ternay, Jr. -- Chemical warfare agent threat to drinking water / Harry Salem ... [et al.] -- Health effects of low-level exposure to nerve agents / John H. McDonough and James A. Romano, Jr. -- Toxicokinetics of nerve agents / Marcel J. van der Schans, Hendrik P. Benschop, and Christopher E. Whalley -- Application of genomic, proteomic, and metabolomic technologies to the development of countermeasures against chemical warfare agents / Jennifer Sekowski and James Dillman -- Novel approaches to medical protection against chemical warfare nerve agents / Ashima Saxena ... [et al.] -- Nerve agent bioscavengers : progress in development of a new mode of protection against organophosphorus exposure / David E. Lenz ... [et al.] -- Butyrylcholinesterase and its synthetic C-terminal peptide confer in-vitro suppression of amyloid fibrils formation / Erez Podoly ... [et al.] -- A novel medical countermeasure for organophosphorus intoxication : connection to Alzheimer's disease and dementia / Edna F. R. Pereira ... [et al.] -- Inhalation toxicology of nerve agents / Paul A. Dabisch ...[et al.] -- Vesicants and oxidative stress / Milton G. Smith ...[et al.] -- Health effects of exposure to vesicant agents / Charles G. Hurst and William J. Smith -- Cyanides : toxicology, clinical presentation, and medical management / Bryan Ballantyne and Harry Salem -- Chemicals used for riot control and personal protection / Harry Salem, Bryan Ballantyne, and Sydney Katz -- Mechanism of action of botulinum neurotoxin and overview of medical countermeasure development for intoxication / Michael Adler ... [et al.] -- Ricin and related toxins : review and perspective / Charles B. Millard and Ross D. LeClaire -- Screening smokes : applications, toxicology, clinical considerations and medical management / Bryan Ballantyne and Harry Salem -- Clinical detection of exposure to chemical warfare agents / Benedict R. Capacio ... [et al.] -- Personal protective equipment (ppe) : practical and theoretical considerations / Michael R. Jones -- Chemical warfare agent decontamination from skin / Brian J. Lukey ... [et al.] -- Chemical warfare, chemical terrorism, and traumatic stress responses : an assessment of psychological impact / James A. Romano, Jr. ... [et al.] -- Emergency response to a chemical warfare agent incident : domestic preparedness, first response, and public health considerations / David H. Moore and Barbara Saunders-Price -- Emergency medical response to a chemical terrorist attack / Stephen A. Pulley and Michael R. Jones.
  • Chimeric toxins 2002, CRCnetBASE
  • Cholera toxins 2009, Springer
  • Chromium (VI) handbook 2005, CRCnetBASE
  • Metallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
  • Computational toxicology 2013, ScienceDirect
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
  • Poisoners throughout history -- Types of poisons -- Poisoners -- Victims -- Crime scene investigation -- The forensic autopsy -- Proving poisoning -- Poisoners in court -- Poisoning in fiction -- Conclusion.
  • Cyanide in water and soil 2006, CRCnetBASE
  • Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
  • Dermatotoxicology. 6th ed. 2004, CRCnetBASE
  • Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • Drug residues in foods 2001, CRCnetBASE
  • Drug safety evaluation 2009, Springer Protocols
    Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
  • I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
  • I. Chapters of general nature. How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) -- Problems in toxin analysis in emergency medicine -- Analyses of chemical warefare agents and their related compounds -- B. Chapters on specific toxins. Volatile compounds -- Controlled drugs -- Psychopharmaceuticals and hypnotics -- General drugs -- Chemicals of daily necessaries -- Natural toxins and alkaloids -- Pesticides -- Miscellaneous.
  • Ecology of harmful algae 2006, Springer
  • "The third edition of a bestseller, this book describes how chemical toxins and biological hazards impact the environment and people. Addressing how pollutants can alter the environment by contributing to global climate change, the author explores a broad range of environmental and health aspects of chemical and biological hazards. He includes numerous examples of the intimate relationship between ecosystem health and human health and emphasizes the need to consider this relationship whenever human activities are likely to have a significant environmental impact"--Provided by publisher.
  • Ecotoxicology 2008, CRCnetBASE
    I. Hierarchical ecotoxicology. The hierarchical science of ecotoxicology -- II. Organismal ecotoxicology. The organismal ecotoxicology context -- Biochemistry of toxicants -- Cells and tissues -- Organs and organ systems -- Physiology -- Bioaccumulation -- Models of bioaccumulation and bioavailability -- Lethal effects -- Sublethal effects -- Conclusion -- III. Population ecotoxicology. The population ecotoxicology context -- Epidemiology : the study of disease in populations -- Toxicants and simple population models -- Toxicants and population demographics -- Phenogenetics of exposed populations -- Population genetics : damage and stochastic dynamics of the germ line -- Population genetics : natural selection -- Conclusion -- IV. Community ecotoxicology. Introduction to community ecotoxicology -- Biotic and abiotic factors that regulate communities -- Biomonitoring and the responses of communities to contaminants -- Experimental approaches in community ecology and ecotoxicology -- Application of multimetric and multivariate approaches in community ecotoxicology -- Disturbance ecology and the responses of communities to contaminants -- Community responses to global and atmospheric stressors -- Effects of contaminants on trophic structure and food webs -- Conclusions -- V. Ecosystem ecotoxicology. Introduction to ecosystem ecology and ecotoxicology -- Overview of ecosystem processes -- Descriptive approaches for assessing ecosystem responses to contaminants -- The use of microcosms, mMesocosms, and field experiments to assess ecosystem responses to contaminants and other stressors -- Patterns and processes : the relationship between species diversity and ecosystem function -- Fate and transport of contaminants in ecosystems -- Effects of global atmospheric stressors on ecosystem processes -- VI. Ecotoxicology : a comprehensive treatment--conclusion -- Conclusion.
  • EndoCANNABINOIDS 2013, Springer
    Part 1.Overview of Non-Cannabinoid Receptors --Overview of Nonclassical Cannabinoid Receptors /Grzegorz Godlewski and George Kunos --Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling /Evangelia Kotsikorou and Patricia Reggio --Part 2.G-Protein Coupled Receptors --GPR55 in the CNS /Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie --The Role of GPR55 in Bone Biology /Lauren S. Whyte and Ruth A. Ross --The Role of GPR55 in Cancer /Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez --GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? /Douglas McHugh and Heather B. Bradshaw --Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia /Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat --Part 3.Ion Channels --Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors /Vincenzo Di Marzo and Luciano De Petrocellis --Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors /Li Zhang and Wei Xiong --Part 4.Transcription Factors --Peroxisome Proliferator-Activated Receptors and Inflammation /James Burston and David Kendall --Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction /Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg --Part 5.Conclusions/Therapeutic Potential --Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors /Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer /Robert A. Hiatt --Puberty as a window of susceptibility /Frank M. Biro and Mary S. Wolff --In search of the optimal experimental model /Irma H. Russo and Jose Russo --Early life exposure to bisphenol A and breast neoplasia /Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto --Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages /Ricardo Lopez de Cicco ... [et al.] --Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A /Sarah Jenkins ... [et al.] --Dioxin as an environmental pollutant and its role in breast cancer /Stephen Safe, Kelcey Walker, and Shu Zhang --Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse /Sally S. White ... [et al.] --Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility /Jennifer L. Rayner and Suzanne E. Fenton --Biological impact of radiation exposure on breast cancer development /David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff --Brain estrogens and metabolism /Yong Xu and Deborah J. Clegg.
  • Environmental toxicology 2004, Wellcome Trust
  • Environmental toxicology 2001, CRCnetBASE
  • Environmental toxicology 2005, ScienceDirect
    The utility of zebrafish as a model for toxicological research / Michael J. Carvan III, Tisha King Heiden and Henry Tomasiewicz -- Use of fish cell lines in the toxicology and ecotoxicology of fish : piscine cell lines in environmental toxicology / N.C. Bols, V.R. Dayeh, L.E.J. Lee and K. Schirmer -- Approaches in proteomics and genomics for eco-toxicology -- Nancy D. Denslow, Iris Knoebl and Patrick Larkin -- Interactions between lipids and persistent organic pollutants in fish / Adria A. Elskus, Tracy K. Collier and Emily Monosson -- Metabolic fate of nonylphenols and related phenolic compounds in fish / Jean-Pierre Cravedi and Daniel Zalko -- Pesticide biotransformation in fish / Daniel Schlenk -- Xenobiotic receptors in fish : Structural and functional diversity and evolutionary insights / Mark E. Hahn, Rebeka R. Merson and Sibel I. Karchner -- Impacts of environmental toxicants and natural variables on the immune system of fishes / Karen G. Burnett -- Fish models of carcinogenesis / Gary K. Ostrander and Jeanette M. Rotchell -- Metallothionein : structure and regulation / Peter Kling and Per-Erik Olsson -- Cell death : investigation and application in fish toxicology / Antony W. Wood, David M. Janz and Glen J. Van Der Kraak -- Adrenal toxicology : environmental pollutants and the HPI axis / Alice Hontela -- Xenobiotic impact on corticosteroid signaling / Mathilakath M. Vijayan, Patrick Prunet and Adrienne N. Boone -- Thyroid hormones / J.G. Eales and S.B. Brown -- The biology and toxicology of retinoids in fish / D. Alsop, Glen J. Van Der Kraak, S.B. Brown and J.G. Eales -- Vitellogenesis and endocrine disruption / Naoshi Hiramatsu, Ann O. Cheek, Craig V. Sullivan, Takahiro Matsubara and Akihiko Hara -- Pharmaceuticals in the environment : drugged fish? / Vance L. Trudeau, Chris D. Metcalfe, Caroline Mimeault and Thomas W. Moon -- P-glycoproteins and xenobiotic efflux transport in fish / Armin Sturm and Helmut Segner.
  • Essential concepts in toxicogenomics 2008, Springer Protocols
    Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
  • Food toxicology 2001, CRCnetBASE
  • Foodborne diseases 2007, Springer
    Escherichia coli / Jianghong Meng and Carl M. Schroeder -- Listeria / Franz Allerberger -- Clostridium botulinum and Clostridium perfringens / Jim McLauchlin and Kathie A. Grant -- Yersinia enterocolitica and Yersinia pseudotuberculosis / Maria Fredriksson-Ahomaa -- Foodborne pathogenic vibrios / T. Ramamurthy and G. Balakrish Nair -- Enterococcus and its association with foodborne illness / Simona F. Oprea and Marcus J. Zervos -- Foodborne viral hepatitis / Hazel Appleton ... [et al.] -- Gastroenteric virus / Miren Iturriza-Gómara, Chris I. Gallimore, and Jim Gray -- Cryptosporidium / Huw V. Smith -- Toxoplasma gondii / Dolores E. Hill ... [et al.] -- Aflatoxins : background, toxicology, and molecular biology / Joan W. Bennett, S. Kale, and Jiujiang Yu -- Scombroid fish poisoning / Elijah W. Stommel -- Pathogen control in meat and poultry production: implementing the USDA food safety and inspection service's hazard analysis and critical control point system / Moshe S. Dreyfuss ... [et al.] -- Use of antimicrobials in food animal production / Frank M. Aaestrup and Lars B. Jensen -- Alternatives to antimicrobials* / Toni L. Poole, Todd R. Callaway, and David J. Nisbet -- Microbial risk assessment / Carl M. Schroeder -- Food irradiation and other sanitation procedures / Donald W. Thayer -- Molecular techniques of detection and discrimination of foodborne pathogens and their toxins / Steven L. Foley and Kathie A. Grant -- Future directions in food safety* / Ross C. Beier and Suresh D. Pillai.
  • "Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
  • Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
  • The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
  • ER-bound steps in the biosynthesis of G protein-coupled receptors /Christian Nanoff and Michael Freissmuth --Role of chaperones in G Protein coupled receptor signaling complex assembly /Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman --GPCR oligomerization: contribution to receptor biogenesis /Kathleen Van Craenenbroeck --The functional size of GPCRs: monomers, dimers or tetramers? /Darlaine Pétrin and Terence E. Hébert --Regulation of post-Golgi traffic of G protein-coupled receptors /Guangyu Wu --Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example /Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo --Regulatory processes governing the cell surface expression of LH and FSH receptors /Deborah L. Segaloff --Chaperone-mediated assembly of G protein complexes /Barry M. Willardson and Christopher M. Tracy --Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies /Jane Dingus and John D. Hildebrandt --Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits /Janet D. Robishaw --G Protein trafficking /Philip B. Wedegaertner --Differential assembly of GPCR signaling complexes determines signaling specificity /Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers --GPCR and voltage-gated calcium channels (VGCC) signaling complexes /Christophe Altier --Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target /Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
  • Handbook of food toxicology 2002, CRCnetBASE
  • The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
  • In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog). A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists. . New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures.
  • Ibuprofen 2012, Springer
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • This book serves as a hands-on guide to various poison treatments and offers supplemental public health information. Each two-page unit features concise text on the left complemented by full-color illustrations on the opposing page. The expert author distinguishes harmful toxic substances and catalogues their specific effects on the human body, plants, animals, and the surrounding environment. The handbook also addresses other topics, including biological warfare, modern toxicological methods, and threshold values. Features include: succinct, user-friendly organization so readers can navigate the content with ease; over 600 detailed images and diagrams arranged on 150 full-color plates illustrate exposures and toxicological effects on humans, plants, and animals; well-researched, objective risk analysis on toxic exposures accompanied by relevant images; extensive glossary of key toxicological terms that provide readers with the accurate information they need to avoid dangerous confusion.
  • Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • v. 1. Principles and methods of immunotoxicology.
  • In vitro neurotoxicology 2004, Springer Protocols
  • Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
  • pt.1. IPCS/OECD key generic terms used in chemical hazard/risk assessment -- pt.2. IPCS glossary of key exposure assessment terminology
  • Jet fuel toxicology 2011, CRCnetBASE
    Air Force-related jet fuel toxicology research (1991-2010) / Walter J. Kozumbo -- Jet fuel composition / Tim Edwards -- The toxicity and underlying mechanism of jet propulsion fuel-8 on the respiratory system / Simon S. Wong and Mark L. Witten -- Neurotoxicological and neurobehavioral effects from exposure to jet fuels / Glenn D. Ritchie -- Differential protein expression following JP-8 jet fuel exposure / Frank A. Witzmann and Mark L. Witten -- Immune modulation by dermal exposure to jet fuel / Gerardo Ramos and Stephen E. Ullrich -- Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components / James E. Riviere, Alfred O. Inman, and Nancy Monteiro-Riviere -- Methods of assessing skin irritation and sensitization of jet fuels / R. Jayachandra Babu, Ram Patlolla, and Mandip Singh -- Understanding systemic and local toxicity of JP-8 after cutaneous exposures / James N. McDougal, James V. Rogers, and Richard Simman -- The effects of aerosolized JP-8 jet fuel exposure on the immune system: a review / David T. Harris -- The involvement of poly(ADP-ribosyl)ation in defense against JP-8 jet fuel and other chemical toxicants / Luis A. Espinoza ... [et al.] -- Evaluation of methods used to generate and characterize jet fuel vapor and aerosol for inhalation toxicology studies / Raphaël T. Tremblay, Sheppard A. Martin, and Jeffrey W. Fisher -- Genetic damage in the blood and bone marrow of mice treated with JP-8 jet fuel / Vijayalaxmi -- Computational analyses of JP-8 fuel droplet and vapor depositions in human upper airway models / Clement Kleinstreuer and Zhe Zhang -- Human exposure to Jet Propellant-8 / Raymond H. Tu and Terence H. Risby.
  • "This book bridges the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments. 10 chapters describe major areas of progress in the laboratory and clinic. In the first section, the aspects of cellular organelles are discussed. In the second, the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches are covered. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally the clinical implications for the understanding of acute and chronic renal toxicity are studied"--Provided by publisher.
  • Evaluting efficacy of barrier creams: in vitro and in vivo models -- Light-induced dermal toxicity: effects on cellular and molecular levels -- Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products -- Exogenous ochronosis: update -- Diagnostic patch test: science and art -- Irritant and allergic contact dermatitis treatment -- Factors affecting children's susceptibility to chemicals -- Utilization of irritation data in local lymph node assay -- Air bag injuries -- Cigarette smoking and skin -- Chemical analysis of tattoo pigments cleaved by laser light -- Dermatotoxicology of specialized epithelia: adapting cutaneous test methods to assess topical effects on vulva -- Anti-irritants: myth or reality? overview -- Evaluating mechanical and chemical irritation using the behind-the-knee tests: review -- Need for more sensitive tools as we reach limits of our ability to detect differences in skin effects from mild products -- Drug patch testing in systemic cutaneous drug allergy -- Hormesis and dermatology -- Diagnosis of drug hypersensitivity in vitro -- Immunologic patterns in allergic and irritant contact dermatitis: similarities -- Water decontamination of chemical skin and eye splashes: critical review -- Chemical substances and contact allergy: 244 substances ranked according to allergenic potency -- Use of modified forearm controlled application test to evaluate skin irritation of lotion formulations -- Hair in toxicology -- Popliteal lymph node assay -- Pigmentation changes resulting from arsenic exposure -- Textiles and human skin, microclimate, cutaneous reactions: overview -- In vivo human transfer of topical bioactive drugs among individuals: estradiol -- Is there evidence that geraniol causes allergic contact dermatitis? -- Operational definition of a causative contact allergen-study with six fragrance allergens -- Sodium lauryl sulfate-induced irritation in human faces: regional- and age-related differences -- Classification of irritant contact dermatitis -- In vitro skin irritation testing on SkinEthic[tm]-reconstituted human epidermis: reproducibility for fifty chemicals tested with two protocols -- Identifying source of textile-dye allergic contact dermatitis: guidelines -- Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate -- Is contact allergy lifelong in humans? an overview of patch-test follow-ups -- Irritants in combination with synergistic or additive effect on skin response overview of tandem irritation studies -- Allergic contact dermatitis from iodine preparations: a conundrum? -- Human skin buffering capacity: oveview.Pesticide percutaneous absorption and decontamination -- Tape stripping method versus stratum corneum -- Parameters influencing stratum corneum removal by tape stripping -- Quantification of stratum corneum removed by tape stripping -- Isolated perfused porcine skin flap -- Physiologically based pharmacokinetic modeling -- Methods for in vitro skin metabolism studies -- Predicitive toxicology methods for transdermal delivery systems -- Animal, human, and in vitro test methods for predicting skin irritation -- Kawaki method for testing irritation -- Analysis of structural change in intercellular lipids of humam stratum corneum induced by surfactants: electron paramagnetic resonance (EPR) study -- Water and saline compresses in treatment of irritant contact dermatitis: literature review -- Reaction of skin blood vessels to successive insults on normal and irritated human skin -- Specificity of retinoid-induced irritation and its role in clinical efficacy -- Topical corticosteroids in the treatment of irritant dermatitis: do they work? -- Tests for sensitive skin -- Test methods for allergic contact dermatitis in animals -- Test methods for allergic contact dermatitis in humans -- Allergic contact dermatitis: elicitation thresholds of potent allergens in humans -- Allergic contact dermatitis to topical anesthetics: a cross-sensitization phenomenon -- Contact urticaria and anaphylaxis to chlorhexidine: overview -- Immunoadjuvants in prospective testing for contact allergens -- Local lymph node assay -- Iontophresis in humans: regional variations in skin barrier function and cutaneous irritation -- Contact urticaria and contact urticaria syndrome (immediate contact reactions) -- In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials -- Photoirritation (phototoxicity) testing in humans -- Measuring and quantifying ultraviolet radiation exposures -- Determination of subclinical changes of barrier function -- Assessing validity of alternative methods for toxicity testing: role and activities of ECVAM -- Animal models of contact urticaria -- Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria -- Cosmetic reactions -- Decreasing allergic contact dermatitis frequency through dermatotoxicologic- and epidemiologic-based intervention? -- Cutaneous corticosteroid-induced glaucoma --Pharmacogenetics and dermatology -- Ethnic differences in skin properties: objective data -- Occlusion and barrier function -- Anatomical factors affecting barrier function -- Percutaneous penetration enhancers: overview -- Percutaneous absorption of complex chemical mixtures -- Percutaneous absorption: short-term exposure, lag time, multiple exposures, model variations, and absorption from clothing -- Percutaneous absorption: 7 roles of lipids -- Chemical partitioning into powdered human stratum corneum: a useful in vitro model for studying interactions of chemicals and human skin -- Sensitive skin -- Transdermal drug delivery system: an overview -- Transdermal drug delivery system: an overview -- Iontophoresis: from historical perspective to its place in modern medicine -- Irritant dermatitis: clinical heterogeneity and contributing factors -- Systemic contact dermatitis -- Allergic contact dermatitis -- Mechanisms in irritant and allergic contact dermatitis -- Occupational allergic contact dermatitis: rational work-up -- Systemic toxicity -- Concepts in molecular dermatotoxicology -- Molecular basis of allergic contact dermatitis -- Photoirritation (phototoxicity, phototoxic dermatitis) -- Permeability of skin to metal compounds, with focus on nickel and copper -- Chemically induced scleroderma -- Chemical agents that cause depigmentation -- Carcinogenesis: current trends in skin cancer research -- Retinoids and mechanisms of their toxicity -- Mechanisms in cutaneous drug hypersensitivity reactions -- Drug-induced ocular phototoxicity -- Water: is it an irritant? -- Sodium lauryl sulfate -- Factors influencing applied amounts of topical preparations -- Barrier creams -- OECD guidelines for testing of chemicals -- Methods for in vitro percutaneous absorption -- Percutaneous absorption of hazardous substances from soil and water --
  • "Up to 200 million people in 70 countries are at risk from drinking water contaminated with arsenic, which is a major cause of chronic debilitating illnesses and fatal cancers. Until recently little was known about the mobility of arsenic, and how redox transformations determined its movement into or out of water supplies. Although human activities contribute to the release of arsenic from minerals, it is now clear that bacteria are responsible for most of the redox transformation of arsenic in the environment. Bacterial oxidation of arsenite (to the less mobile arsenate) has been known since 1918, but it was not until 2000 that a bacterium was shown to gain energy from this process. Since then a wide range of arsenite-oxidizing bacteria have been isolated, including aerobes and anaerobes; heterotrophs and autotrophs; thermophiles, mesophiles and psychrophiles. This book reviews recent advances in the study of such bacteria. After a section on background geology and health issues the main body of the book concerns the cellular machinery of arsenite oxidation. It concludes by examining possible applications. Topics treated are: The geology and cycling of arsenic Arsenic and disease Arsenite oxidation: physiology, enzymes, genes, and gene regulation. Community genomics and functioning, and the evolution of arsenite oxidation Microbial arsenite oxidation in bioremediation Biosensors for arsenic in drinking water and industrial effluents"--Provided by publisher."Arsenite contamination of drinking water is a major cause of chronic illness and mortality in many countries, but until recently little was known of the processes determining its movement and concentration. Bacterial oxidation of arsenite was first described in 1918 and thought to be a means of detoxification. It was not until 2000 that the first autotrophic arsenite-oxidising bacterium was isolated and shown to gain energy from arsenite oxidation. Since then a wide range of such bacteria has been isolated and the literature on the topic has grown rapidly. This book reviews the new understanding of the diversity and abundance of such organisms, their role in arsenic cycling in the environment and their possible relations with arsenic-dependent diseases in humans"-- Provided by publisher.
  • Molecular toxicology 2004, CRCnetBASE
  • Molecular toxicology protocols 2004, Springer Protocols
    Analysis of K-RAS and P53 mutations in sputum samples / Weimin Gao and Phouthone Keohavong -- Allele-specific competitive blocker-PCR detection of rare base substitution / Barbara L. Parsons, Page B. McKinzie, and Robert H. Heflich -- Gel-based nonradioactive single-strand conformational polymorphism and mutation detection: limitations and solutions / Vibhuti Gupta ... [et al.] -- Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions / Toshinari Minamoto -- Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR / Michael J. Villalobos, Christopher J. Betti, and Andrew T.M. Vaughan -- Microsatellite instability: an indirect assay to detect defects in the cellular mismatch repair machinery / Anjana Saha, Narendra K. Bairwa, and Ramesh Bamezai -- Unscheduled DNA synthesis: a functional assay for global genomic nucleotide excision repair / Crystal M. Kelly and Jean J. Latimer -- Analysis of DNA repair using transfection-based host cell reactivation / Jennifer M. Johnson and Jean J. Latimer -- An immunoassay for measuring repair of ultraviolet photoproducts / Shirley McCready -- Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells / Petra Pfeiffer ... [et al.] --The comet-FISH technique: a tool for detection of specific DNA damage and repair / Alexander Rapp, Michael Hausmann, and Karl Otto Greulich -- DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis / Nina Joshi and Stephen G. Grant -- Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes / Vasily N. Dobrovolsky, Joseph G. Shaddock, and Robert H. Heflich -- Quantifying in vivo somatic mutations using transgenic mouse model systems / Roy R. Swiger -- Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants / Sai-Mei Hou -- Molecular analysis of mutations in the human HPRT gene / Phouthone Keohavong, Liqiang Xi, and Stephen G. Grant -- Simultaneous quantification of t(14;18) and HPRT exon 2/3 deletions in human lymphocytes / James C. Fuscoe -- The GPA in vivo somatic mutation assay / Stephen G. Grant -- Flow cytometric measurement of mutant T cells with altered expression of TCR: detecting somatic mutations in humans and mice / Seishi Kyoizumi, Yoichiro Kusunoki, and Tomonori Hayashi -- Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis / Therese Sørlie ... [et al.] --³²P-postlabeling analysis of DNA adducts / David H. Phillips, Alan Hewer, and Volker M. Arlt -- Modification of the ³²P-postlabeling method to detect a single adduct as a single spot / Masako Ochiai, Takashi Sugimura, and Minako Nagao -- DNA isolation and sample preparation for quantification of adduct levels by accelerator mass spectrometry / Karen H. Dingley ... [et al.] -- Fluoroimaging-based immunoassay of DNA photoproducts in ultraviolet-B-irradiated tadpoles / Iovanna Pandelova, Stephen R. Hewitt, and John B. Hays -- Analysis of DNA strand cleavage at abasic sites / Walter A. Deutsch and Vijay Hegde -- Premature chromosome condensation in human resting peripheral blood lymphocytes for chromosome aberration analysis using specific whole-chromosome DNA hybridization probes / Pataje G.S. Prasanna and William F. Blakely -- Mutagen-induced chromatid breakage as a marker of cancer risk / Xifeng Wu, Yun-Ling Zheng, and T.C. Hsu -- Flow cytometric analysis of micronuclei in erythrocytes / Jan Grawé -- The comet assay: a sensitive genotoxicity test for the detection of DNA damage / Günter Speit and Andreas Hartmann -- Computerized image analysis software for the comet assay / R.C. Chaubey --Measuring recombination proficiency in mouse embryonic stem cells / Andrew J. Pierce and Maria Jasin -- Strategies for measurement of biotransformation enzyme gene expression / Marjorie Romkes and Shama C. Buch -- Genotyping technologies: application to biotransformation enzyme genetic polymorphism screening / Marjorie Romkes and Shama C. Buch -- TaqMan® fluorogenic detection system to analyze gene transcription in autopsy material / Kaori Shintani-Ishida, Bao-Li Zhu, and Hitoshi Maeda -- Development of quantitative reverse transcriptase PCR assays for measuring gene expression / Tony E. Godfrey and Lori A. Kelly -- Quantification of selective phosphatidylserine oxidation during apoptosis / James P. Fabisiak ... [et al.] -- Quantitative method of measuring of phosphatidylserine externalization during apoptosis using electron paramagnetic resonance spectroscopy and annexin-conjugated iron / James P. Fabisiak, Grigory G. Borisenko, and Valerian E. Kagan -- Detection of programmed cell death in cells exposed to genotoxic agents using a caspase activation assay / Michael E. Gehring and Patrick P. Koty.
  • Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Morphine and metastasis 2013, Springer
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Mycotoxins in food 2004, CRCnetBASE
  • Chemical weapons -- Chemical warfare agents -- Organophosphates and nerve agents -- Toxicodynamics -- Antidotal treatment -- Prophylaxis.
  • This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • Ovarian toxicology 2004, CRCnetBASE
  • "Today, we are exposed to an ever-growing number of chemicals in the environment and there is an increasing awareness of the effects of these chemicals on the ovaries. As such, the potential for xenobiotic-induced infertility needs to be better understood. Additionally, menopause-associated disorders are of growing health concern in view of the fact that by the year 2025, 19.5% of the population of the U.S. will be menopause-aged women. Exploring research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles, this book is an essential resource for researchers in academia, regulatory agencies, and industry"--Provided by publisher.
  • Particle toxicology 2007, CRCnetBASE
    An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly Bérubé -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody --Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderón-Garcidueñas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schülte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm.
  • Pasteurella multocida 2012, Springer
    Pasteurella multocida: Diseases and Pathogenesis /I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler --Pathogenomics of Pasteurella multocida /J. D. Boyce, T. Seemann, B. Adler and M. Harper --The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide /Marina Harper, John D. Boyce and Ben Adler --Pasteurella multocida and Immune Cells /Katharina F. Kubatzky --Molecular Biology of Pasteurella multocida Toxin /Joachim H. C. Orth and Klaus Aktories --Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects /Brenda A. Wilson and Mengfei Ho --Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin /Yasuhiko Horiguchi --The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer /Alistair Lax.
  • Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
  • Pesticide protocols 2005, Springer Protocols
  • Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
  • Print Material
  • Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
  • Print Material
  • Introduction to postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Specimen selection, collection, preservation, and security / Bradford R. Hepler and Daniel S. Isenschmid -- Common methods in postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Strategies for postmortem toxicology investigation / edited and revised by Henrik Druid -- Quality assurance in postmortem toxicology / Wilmo Andollo -- Interpretation of postmortem drug levels / Graham R. Jones.
  • Predictive toxicology 2005, CRCnetBASE
  • Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
  • Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • Ricin and Shiga toxins 2012, Springer
  • Riot control agents 2004, CRCnetBASE
  • This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Salmonella 2007, Springer Protocols
    Quantitative, multiplexed detection of salmonella and other pathogens by Luminex xMAP suspension array / Sherry A. Dunbar and James W. Jacobson -- Detection of salmonella by bacteriophage felix 01 / Jonathan C. Kuhn -- Physical mapping of salmonella genomes / Shu-Lin Liu -- Cloth-based hybridization array system for the identification of antibiotic resistance genes in salmonella / Burton W. Blais and Martine Gauthier -- Genome-based identification and molecular analysee of pathogenicity islands and genomic islands in Salmonella enterica / Michael Hensel -- Determination of the gene content of salmonella genomes by microarray analysis / Steffen Porwollik and Michael McClelland -- In vivo excision, cloning, and broad-host-range transfer of large bacterial DNA segments using VEX-capture / James W. Wilson and Cheryl A. Nickerson -- Amplified fragment length polymorphism analysis of Salmonella enterica / Ruiting Lan and Peter R. Reeves -- Salmonella phages and prophages : genomics and practical aspects / Andrew M. Kropinski ... [et al.] -- Salmonella typhimurium phage typing for pathogens / Wolfgang Rabsch -- Salmonella phages examined in the electron microscope / Hans-W. Ackermann -- Applications of cell imaging in salmonella research / Charlotte A. Perrett and Mark A. Jepson -- Analysis of kinesin accumulation on salmonella-containing vacuoles / Audrey Dumont ... [et al.] -- Magnesium, manganese, and divalent cation transport assays in intact cells / Michael E. Maguire -- Methods in cell-to-cell signaling in salmonella / Brian M. M. Ahmer ... [et al.] -- Development of salmonella strains as cancer therapy agents and testing in tumor cell lines / Abraham Eisenstark ... [et al.] -- Further resources for molecular protocols in salmonella research / Abraham Eisenstark and Kelly K. Edwards.
  • "Includes comprehensive hazard information on the substances encountered in the workplace. The objective of the work is to promote safety by providing the most up-to-date hazard information available"--Provided by publisher."Since its inception in the early 1950's, this book has become the "bible" for those who need to evaluate the hazard of substances used in commerce. The book contains extensive data on approximately 28,000 substances. It is designed to fill the information needs of professionals who must work with and evaluate the hazards of chemicals"--Provided by publisher.
  • Sphingolipids 2013, Springer
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Sphingolipids in disease 2013, Springer
    Sphingolipids in Cancer.Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance /Shanmugam Panneer Selvam, Besim Ogretmen --Using ASMase Knockout Mice to Model Human Diseases /Guoqiang Hua, Richard Kolesnick --New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer /Susan Pyne, Nigel J. Pyne --Sphingolipids and Response to Chemotherapy /Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard --Lung Cancer and Lung Injury: The Dual Role of Ceramide /Tzipora Goldkorn, Samuel Chung, Simone Filosto --Sphingolipids' Role in Radiotherapy for Prostate Cancer /Carla Hajj, Adriana Haimovitz-Friedman --Sphingolipids in Cardio-Reno-vascular Diseases.Sphingolipid Metabolism and Atherosclerosis /Xian-Cheng Jiang, Jing Liu --Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) /Bodo Levkau --Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease /Pin-Lan Li, Yang Zhang --Sphingolipids in Inflammation, Infection and Lung Diseases.Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity /Taimur Abbasi, Joe G. N. Garcia --Sphingolipids in Acute Lung Injury /Stefan Uhlig, Yang Yang --The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases /Irina Petrache, Daniela N. Petrusca --Ceramide in Cystic Fibrosis /Heike Grassmé, Joachim Riethmüller, Erich Gulbins --Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway /K. Alexa Orr Gandy, Lina M. Obeid --Bacterial Infections and Ceramide /Heike Grassmé, Katrin Anne Becker --Viral Infections and Sphingolipids /Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies --Ceramide in Plasma Membrane Repair /Annette Draeger, Eduard B. Babiychuk --Sphingolipids and Inflammatory Diseases of the Skin /Burkhard Kleuser, Lukasz Japtok --Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease /S. B. Russo, J. S. Ross, L. A. Cowart --Sphingolipids in Neuro-psychiatry and Muscle Diseases.Neuronal Forms of Gaucher Disease /Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation /Laura Davies, Klaus Fassbender, Silke Walter --Sphingolipids in Psychiatric Disorders and Pain Syndromes /C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber --Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology /Paola Bruni, Chiara Donati.
  • Temperature and toxicology 2005, CRCnetBASE
  • Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.
  • International and federal bodies involved in risk assessment of chemical substances -- Data for hazard assessment -- Hazard assessment -- Standard setting : threshold effects -- Standard setting : non-threshold effects (carcinogenicity) -- Exposure assessment -- Risk characterization -- Regulatory standards set by various bodies -- Combined actions of chemicals in mixture.
  • Introduction: the gastrointestinal (GI) tract as a barrier and as an absorptive and metabolic organ / Shayne C. Gad -- Methods for the analysis of gastrointestinal function / Robin C. Guy -- Safety pharmacology and the GI tract / Henry I. Jacoby -- Gastronintestinal tract development and its importance in toxicology / Joseph V. Rodricks, Allison A. Yates, and Claire L. Kruger -- The GI tract as major route of pharmaceutical administration / Robert W. Kapp, Jr. -- Gastrointestinal function and toxicology in canines / Charles Spainhour -- Absorption of macromolecules by mammalian intestinal epithelium / Shayne C. Gad -- Peyer's patch epithelium: an imperfect barrier / Gary R. Burleson and Florence G. Burleson -- Alteration of intestinal function by xenobiotic exposure: animal models / Shayne C. Gad -- Intestinal absorption and metabolism of xenobiotics in laboratory animals / William J. Brock -- Normal and abnormal intestinal absorption by humans / David W. Hobson and Valerie L. Hobson -- Intestinal absorption and metabolism of xenobiotics in humans / William J. Brock and David W. Hobson.
  • Toxicology of the pancreas 2005, CRCnetBASE
  • Toxicology of the skin 2010, CRCnetBASE
    Pt. 1. Skin morphology and barrier properties -- pt. 2. Altered barriers -- pt. 3. Methods of delivery -- pt. 4. Skin toxicity.
  • Toxins in food 2005, CRCnetBASE
  • Treatments from toxins 2007, CRCnetBASE
  • "The purpose of this publication is to provide its users with guidance to identify, acquire and use the information needed to assess chemical hazards, exposures and the corresponding health risks in their given health risk assessment contexts at local and/or national levels. The toolkit provides information for conducting a human health risk assessment, identifies information that must be gathered to complete an assessment and provides electronic links to international resources from which the user can obtain information and methods essential for conducting the human health risk assessment"--Publisher's description.
all 227 titles

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Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides one-click access to important clinical resources; includes evidence-based diagnosis and treatment guidelines, Books, EBM articles, Ovid MEDLINE, Drug facts and comparisons, Drug interaction facts, guidelines from National Guideline Clearinghouse, patient handouts (English and Spanish), and local content.MD consult provides access to textbooks, electronic journals, practice guidelines, drug information, and patient education handouts.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.