Books by Subject

all 263 titles

Toxicology

  • 2012 Springer
    Chang-Hwei Chen.
  • 2013 Springer
    edited by Grant N. Pierce, Volodymyr I. Mizin and Alexander Omelchenko.
    "The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.
  • 2013 Springer
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • 2013 Springer
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • 2012 ScienceDirect
    edited by Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova.
    A. Engineered nanomaterials: hazard, exposure and safety assessment. Interactions with the human body / Renato Colognato ... [et al.] -- Exposure assessment / Antonio Bergamaschi, Ivo Iavicoli and Kai Savolainen -- Biomonitoring / Enrico bergamaschi and Andrea Magrini -- Critical evaluation of toxicity tests / Maria Dusinska ... [et al.] -- Computational approaches / Vidana Epa, Dave Winkler and Lang Tran -- Regulation and legislation / Maureen R. Gwinn and Birgit Sokull-Klüttgen -- B. Engineered nanomaterials: impact on human health. Respiratory system / Ken Donaldson and Craig Poland -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills and Rodger Duffin -- Neurological system / Sandra Ceccatelli and Giuseppe Bardi -- Immune system / Diana Boraschi and Albert Duschl -- Skin / Nancy A. Monteiro-Riviere and Francesca Larese Filon -- Gastrointestinal tract / Mark A. Jepson -- Reproductive toxicity / Karin Sørig Hougaard and Luisa Campagnolo -- Genotocicity and cancer / Shareen H. Doak, Ying Liu and Chunying Chen -- C. Biomedical applications of engineered nanomaterials. Diagnostic applications / Kalcheng and Zhen Cheng -- Therapeutic applications / Cyrill Bussy ... [et al.] -- Annex: synthesis of engineered nanomaterials / Muhammet S. toprak, Gulaim A. Seisenbaeva and Vadim G. Kessler.
  • 2013 WHO
    IOMC, Inter-Organization Programme for the Sound Management of Chemicals.
    Also available: Print – 2013
  • 2009
    editors: Cheryl J. Cherpitel [and others].
    Status: Not Checked OutLane Catalog Record
  • 2016 NLM
  • 2006 Springer
    edited by Manuel J. Reigosa, Nuria Pedrol and Luís González.
    General -- Methodological aspects -- Physiological aspects of allelopathy -- Ecophysiology and allelopathy -- Ecological aspects of allelopathy -- Allelopathy in different environments -- Applied aspects of allelopathy.
  • 2008 CRCnetBASE
    editor, José L. Tadeo.
    Pesticides: classification and properties / José L. Tadeo, Consuelo Sánchez-Brunete, Lorena González -- Sample handling of pesticides in food and environmental samples / Esther Turiel, Antonio Martín-Esteban -- Analysis of pesticides by chromatographic techniques coupled with mass spectrometry / Simon Hird -- Immunoassays and biosensors / Jeanette M. Van Emon ... [et al.] -- Quality assurance / Árpád Ambrus -- Determination of pesticides in food of vegetal origin / Frank J. Schenck, Jon W. Wong -- Determination of pesticides in food of animal origin / Antonia Garrido Frenich, Jose Luis Martinez, Adrian Covaci -- Determination of pesticides in soil / Consuelo Sánchez-Brunete, Beatriz Albero, José L. Tadeo -- Determination of pesticides in water / Jay Gan, Svetlana Bondarenko -- Sampling and analysis of pesticides in the atmosphere / Maurice Millet -- Levels of pesticides in food and food safety aspects / Kit Granby ... [et al.] -- Monitoring of pesticides in the environment / Ioannus Konstantinou ... [et al.].
  • 2007 CRCnetBASE
    edited by Pascal Kintz.
    Drug incorporation into hair / Robert Kronstrand and Karen Scott -- Passive exposure, decontamination procedures, cutoffs, and bias: pitfalls in the interpretation of hair analysis results for cocaine use / David A. Kidwell and Frederick P. Smith -- Opioids testing in hair / Michel Yegles and Robert Wennig -- Hair analysis for cocaine / Carmen Jurado -- Determination of cannabinoids in human hair / Michael Uhl -- Amphetamine determination in hair / Vincent Cirimele -- Pharmaceuticals in hair / Marjorie Cheze, Marc Deveaux, Gaelle Duffort, Francis Billault, and Gilbert Pepin -- Screening strategies in hair analysis on drugs / Hans Sachs -- Clinical applications of hair analysis / Simona Pichini, Oscar Garcia-Algar, and Rafael de la Torre -- Hair in postmortem toxicology / Robert Kronstrand and Henrik Druid -- Detection of doping agents in human hair / Pascal Kintz -- Applications of hair in drug-facilitated crime evidence / Marion Villain -- Application of hair in driving-license regranting / Manfred R. Moeller, Hans Sachs, and Fritz Pragst -- Alcohol markers in hair / Fritz Pragst and Michel Yegles -- Workplace drug testing using hair samples / Thomas Cairns, Michael Schaffer, and Virginia Hill -- Metals / Jean-Pierre Goulle.
  • 2008 CRCnetBASE
    G.O. Evans.
    Hemopoiesis, blood cell types, and bone marrow examination -- Erythrocytes, anemias, and polycythemia -- Additional erythrocytic measurements -- Iron, associated proteins, and vitamins -- Leukocytes -- Immunotoxicology -- Hemostasis -- Pre-analytical variables -- Analytical variables and biosafety -- Data processing and interpretation.
  • 2007 CRCnetBASE
    edited by Shayne C. Gad.
    The mouse -- The rat -- The hamster -- The guinea pig -- The rabbit -- The ferret -- The dog -- Primates -- The minipig -- Alternative species / Shayne C. Gad -- Clinical pathology of laboratory animals / Robert L. Hall -- Model selection and scaling / Shayne C. Gad -- Susceptibility factors / Shayne C. Gad -- Laws and regulations governing animal care and use in research / Shayne C. Gad.
  • 2007 NAP
    Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies.
  • 2015 Springer
    Chris Peers, Prem Kumar, Christopher Wyatt, Estelle Gauda, Colin A. Nurse, Nanduri Prabhakar, editors.
    Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
    Also available: Print – 2015
  • 2013 Springer
    Andrea B. Weir, Margaret Collins, editors.
    Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
  • 2014 Springer
    Chirukandath Gopinath, Vasanthi Mowat.
    "This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years."--Publisher's website.
  • 2014 Springer
    Mahdi Balali-Mood, Mohammad Abdollahi, editors.
    This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.
  • 2007 CRCnetBASE
    Jacqueline L. Robertson ... [et al.].
  • 2006 CRCnetBASE
    edited by James R. Swearengen.
  • 2003 ANSI, Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-3
  • 2009 ClinicalKey
    Joseph Jankovic, chief editor ; Alberto Albanese [and others].
    The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat, such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you'll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.
  • 2013 Springer
    Aamir Ahmad, editor.
    This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed -- source other than Library of Congress.
  • 2013 Springer
    Tyler J. Curiel, editor.
    This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • 2014 Springer
    Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors.
    This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • 2010 IARC
    Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
    Also available: Print – 2010
  • 2008 CRCnetBASE
    edited by David G. Penney.
  • 2008 CRCnetBASE
    Silvana Fiorito.
  • 2008
    editor, Curtis D. Klaassen.
    Status: Not Checked OutLane Catalog Record
    Unit I: General principles of toxicology -- History and scope of toxicology / Michael A. Gallo -- Principles of toxicology / David L. Eaton and Steven G. Gilbert -- Mechanisms of toxicity / Zoltán Gregus -- Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Unit II: Disposition of toxicants -- Absorption, Distribution, and excretion of toxicants / Lois D. Lehman-McKeeman -- Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie -- Toxicokinetics / Danny D. Shen -- Unit III: Non-organ-directed toxicity -- Chemical carcinogens / James E. Klaunig and Lisa M. Kamendulis -- Genetic toxicology / R. Julian Preston and George R. Hoffmann -- Developmental toxicology / John M. Rogers and Robert J. Kavlock -- Unit IV: Target organ toxicity -- Toxic responses of the blood / John C. Bloom and John T. Brandt -- Toxic responses of the immune system / Norbert E. Kaminski ... [et al.] -- Toxic responses of the liver / Hartmut Jaeschke -- Toxic responses of the kidney / Rick G. Schnellmann -- Toxic responses of the respiratory system / Hanspeter R. Witschi ... [et al.] -- Toxic responses of the nervous system / Virginia C. Moser ... [et al.] -- Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes -- Toxic responses of the heart and vascular system / Y. James Kang -- Toxic responses of the skin / Robert H. Rice and Theodora M. Mauro -- Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray Jr. -- Toxic responses of the endocrine system / Charles C. Capen -- Unit V: Toxic agents -- Toxic effects of pesticides / Lucio G. Costa -- Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes -- Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand, and D. Alan Warren -- Health effects of radiation and radioactive materials / Naomi H. Harley -- Properties and toxicities of animal venoms / John B. Watkins, III -- Toxic effects of plants / Stata Norton -- Unit VI: Environmental toxicology -- Air pollution / Daniel L. Costa -- Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Unit VII: Applications of toxicology -- Food toxicology / Frank N. Kotsonis and George A. Burdock -- Analytic/forensic toxicology / Alphonse Poklis -- Clinical toxicology / Louis R. Cantilena Jr. -- Occupational toxicology / Peter S. Thorne.
  • 2011 Springer
    Trevor M. Penning, Editor.
    Historical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
  • 2007 CRCnetBASE
    edited by Karen A. Barnes, C. Richard Sinclair and D.H. Watson.
    pt. 1. Regulation and quality control of chemical migration into food -- pt. 2. Assessing the risks and improving the safety of food contact materials -- pt. 3. Chemical migration from particular food contact materials.
  • v. 3-4, 1996-97.
    William J. Rea.
    Status: Not Checked OutLane Catalog Record
    v. 3. Clinical manifestations of pollutant overload -- v. 4. Tools of diagnosis and methods of treatment.
  • 2008 CRCnetBASE
    edited by James A. Romano, Jr., Brian J. Lukey, Harry Salem.
    Brief history and use of chemical warfare agents in warfare and terrorism / Harry Salem, Andrew L. Ternay, Jr., and Jeffery K. Smart -- The chemistry of chemical warfare agents / Peter Kikilo, Vitaly Fedorenko, and Andrew L. Ternay, Jr. -- Chemical warfare agent threat to drinking water / Harry Salem ... [et al.] -- Health effects of low-level exposure to nerve agents / John H. McDonough and James A. Romano, Jr. -- Toxicokinetics of nerve agents / Marcel J. van der Schans, Hendrik P. Benschop, and Christopher E. Whalley -- Application of genomic, proteomic, and metabolomic technologies to the development of countermeasures against chemical warfare agents / Jennifer Sekowski and James Dillman -- Novel approaches to medical protection against chemical warfare nerve agents / Ashima Saxena ... [et al.] -- Nerve agent bioscavengers : progress in development of a new mode of protection against organophosphorus exposure / David E. Lenz ... [et al.] -- Butyrylcholinesterase and its synthetic C-terminal peptide confer in-vitro suppression of amyloid fibrils formation / Erez Podoly ... [et al.] -- A novel medical countermeasure for organophosphorus intoxication : connection to Alzheimer's disease and dementia / Edna F. R. Pereira ... [et al.] -- Inhalation toxicology of nerve agents / Paul A. Dabisch ...[et al.] -- Vesicants and oxidative stress / Milton G. Smith ...[et al.] -- Health effects of exposure to vesicant agents / Charles G. Hurst and William J. Smith -- Cyanides : toxicology, clinical presentation, and medical management / Bryan Ballantyne and Harry Salem -- Chemicals used for riot control and personal protection / Harry Salem, Bryan Ballantyne, and Sydney Katz -- Mechanism of action of botulinum neurotoxin and overview of medical countermeasure development for intoxication / Michael Adler ... [et al.] -- Ricin and related toxins : review and perspective / Charles B. Millard and Ross D. LeClaire -- Screening smokes : applications, toxicology, clinical considerations and medical management / Bryan Ballantyne and Harry Salem -- Clinical detection of exposure to chemical warfare agents / Benedict R. Capacio ... [et al.] -- Personal protective equipment (ppe) : practical and theoretical considerations / Michael R. Jones -- Chemical warfare agent decontamination from skin / Brian J. Lukey ... [et al.] -- Chemical warfare, chemical terrorism, and traumatic stress responses : an assessment of psychological impact / James A. Romano, Jr. ... [et al.] -- Emergency response to a chemical warfare agent incident : domestic preparedness, first response, and public health considerations / David H. Moore and Barbara Saunders-Price -- Emergency medical response to a chemical terrorist attack / Stephen A. Pulley and Michael R. Jones.
  • 2012 CRCnetBASE
    edited by Philip Wexler ... [et al.].
    The Context. Creating and Controlling Chemical Hazards: A Brief History / Jody A. Roberts -- Conferences. Stockholm, 1972: Conference on the Human Environment / Lars-Göran Engfeldt -- Rio 1992: The UN Conference on Environment and Development (The "Earth Summit") / Shelley Kath -- Johannesburg (2002) The World Summit on Sustainable Development / Shelley Kath -- International Conference on Chemicals Management 1 / Linn Persson and Viveka Bohn -- ICCM-2: Cementing Process and Making Progress toward the 2020 Goal / Melanie Ashton and Pia M. Kohler -- Global/Multilateral Instruments. The Aarhus Convention: Impact on Sound Chemicals Management with Special Emphasis on Africa / Ebeh Adayade Kodjo -- Global Collaborations in Managing Chemical and Environmental Risks: The Basel Convention--A Promising Future / Pierre Portas -- The Climate Change Convention and the Kyoto Protocol / Bert Metz -- Convention on Long-Range Transboundary Air Pollution / Johan Sliggers -- The Globally Harmonised System of Classification and Labelling of Chemicals: The System, Its History and Context, and the Future of Implementation / Cheryl Chang -- The International Code of Conduct on Distribution and Use of Pesticides / Gamini Manuweera -- The Kiev Protocol on Pollutant Release and Transfer Registers / Michael Stanley-Jones -- The Rotterdam Convention / Ernest Mashimba -- Implementing the Stockholm Convention: An Increasingly Expensive Challenge / Pia M. Kohler and Melanie Ashton -- The Vienna Convention, Montreal Protocol, and Global Policy to Protect Stratospheric Ozone / David Downie -- SAICM. Strategic Approach to International Chemicals Management: Development and Opportunities / Hamoudi Shubber -- Organizations. Food and Agriculture Organization / Mark Davis -- International Chemicals Management within the Global Environmental Governance Context / Achim Halpaap -- Managing Chemical Risks: The Role of the Chemical Industry / Michael Walls -- The Intergovernmental Forum on Chemical Safety / Jack Weinberg -- International Labour Organization's Activities in the Area of Chemical Safety / Pavan Baichoo -- Inter-Organization Programme for the Sound Management of Chemical / Jan van der Kolk -- The International Panel on Chemical Pollution / Martin Scheringer, Åke Bergman, and Heidelore Fiedler -- The Role of the International POPs Elimination Network / Mariann Lloyd-Smith -- Organization for Economic Cooperation and Development / Richard Sigman -- The Chemical Weapons Convention and the Work of the Organisation for the Prohibition of Chemical Weapons / Boitumelo V. Kgarebe and Cristina B. Rodrigues -- National and International Scientific Societies' Role in Global Collaboration in Chemicals Management / John Duffus -- The Role of United Nations Development Programme in Sound Chemicals Management / Jan van der Kolk -- United Nations Environment Programme and UNEP Chemicals / Jan van der Kolk -- United Nations Industrial Development Organization / Heinz Leuenberger and Elisa Tonda -- United Nations Institute for Training and Research / Craig Boljkovac and Jan van der Kolk -- The Contributions of the World Health Organization to Sound Chemicals Management / John A. Haines -- The Intergovernmental Panel on Climate Change / Bert Metz -- Representative Country Implementations. Chilean Approach to Chemical Safety and Management / Asish Mohapatra and Sergio Peña Neira -- Chemical Management System in China: Past, Present, Future / DaeYoung Park -- Chemicals in Egypt: A Generic Perspective / Mohamed Tawfic Ahmed and Naglaa M. Loutfi -- Capacities for Chemicals and Pesticides Management in Ghana / John A. Pwamang -- Chemicals Management and Safety in India / Ravi Agarwal -- São Tomé and Príncipe and the Issue of Persistent Organic Pollutants / Arlindo Carvalho -- Activities, Challenges, and Accomplishments of the Republic of Slovenia in the Implementation of Chemical Management Instruments / Marta Ciraj -- Implementation of the Rotterdam Convention in Third World Countries: The Tanzania Experience / Ernest Mashimba -- Regional Activities. Tripartite Environmental Collaboration between China, Japan, and Korea in Chemical Management / Dae Young Park -- REACH: Next Step to a Sound Chemicals Management / Arnold van der Wielen -- North America Cooperation in Chemical Management / Asish Mohapatra and Phil Wexler -- Regional Cooperation among South Asian Association for Regional Cooperation Countries in the Areas of Chemical and Environmental Risk Management / Lakshmi Raghupathy, Asish Mohapatra, Ravi Agarwal, and Jan van der Kolk -- Invited Essays. A Global Approach to Environmental Emergencies / Chris Dijkens -- Emerging Issues in Global Chemical Policy / Franz Perrez and Georg Karlaganis -- Financing Instruments Related to Chemicals and Waste Management / Ibrahima Sow -- Information Resources Supporting Global Chemicals Policy and Management / Asish Mohapatra and Philip Wexler -- Future Outlook. Future Outlook and Challenges / Jan van der Kolk and Ravi Agarwal.
  • 2005 Springer
    edited by Mendel Friedman and Don Mottram.
    Also available: Print – 2005
  • 2009 Springer
    Keya Chaudhuri, S.N. Chatterjee.
  • 2005 CRCnetBASE
    written by Independent Environmental Technical Evaluation Group (IETEG) ; edited by Jacques Guertin, James A. Jacobs, Cynthia P. Avakian.
  • 2014 WHO
    Also available: Print – 2014
  • 2009 ClinicalKey
    [edited by] Michael R. Dobbs.
    Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors, such as heavy metals and pesticides, and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection.
  • 2006 IARC
    Metallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
    Also available: Print – 2006
  • 2008 ScienceDirect
    edited by Christer Hogstrand and Peter Kille.
  • 2013 ScienceDirect
    edited by Bruce A. Fowler.
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
  • v.1-2=, 2012 Springer Protocols
    v.2 (2012) Springer Protocols
    edited by Brad Reisfeld, Arthur N. Mayeno.
    V. 1. What is computational toxicology? / Brad Reisfeld and Arthur N. Mayeno. Computational toxicology : application in environmental chemicals / Yu-Mei Tan [and others] Role of computational methods in pharmaceutical sciences / Sandhya Kortagere, Markus Lill, and John Kerrigan. Best practices in mathematical modeling / Lisette G. de Pillis and Ami E. Radunskaya. Tools and techniques / Arthur N. Mayeno and Brad Reisfeld. Prediction of physicochemical properties / John C. Dearden. Informing mechanistic toxicology with computational molecular models / Michael R. Goldsmith [and others] Chemical structure representations and applications in computational toxicity / Muthukumarasamy Karthikeyan and Renu Vyas. Accessing and using chemical property databases / Janna Hastings, Zara Josephs, and Christoph Steinbeck. Accessing, using, and creating chemical property databases for computational toxicology modeling / Antony J. Williams [and others] Molecular dynamics / Xiaolin Cheng and Ivaylo Ivanov. Introduction to pharmacokinetics in clinical toxicology / Pavan Vajjah, Geoffrey K. Isbister, and Stephen B. Duffull. Modeling of absorption / Walter S. Woltosz, Michael B. Bolger, and Viera Lukacova. Prediction of pharmacokinetic parameters / A.K. Madan and Harish Dureja. Ligand- and structure-based pregnane X receptor models / Sandhya Kortagere, Matthew D. Krasowski, and Sean Ekins. Non-compartmental analysis / Johan Gabrielsson and Daniel Weiner. Compartmental modeling in the analysis of biological systems / James B. Bassingthwaighte [and others] Physiologically based pharmacokinetic/toxicokinetic modeling / Jerry L. Campbell [and others] Interspecies extrapolation / Elaina M. Kenyon. Population effects and variability / Jean Lou Dorne [and others] Mechanism-based pharmacodynamic modeling / Melanie A. Felmlee, Marilyn E. Morris, and Donald E. Mager -- v. 2. Methods for building QSARs / James Devillers. Accessing and using chemical databases / Nikolai Nikolov [and others] From QSAR to QSIIR : searching for enhanced computational toxicology models / Hao Zhu. Mutagenicity, carcinogenicity, and other end points / Romualdo Benigni [and others] Classification models for safe drug molecules / A.K. Madan, Sanjay Bajaj, and Harish Dureja. QSAR and metabolic assessment tools in the assessment of genotoxicity / Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova. Gene expression networks / Reuben Thomas and Christopher J. Portier. Construction of cell type-specific logic models of signaling networks using CellNOpt / Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez. Regulatory networks / Gilles Bernot, Jean-Paul Comet, and Christine Risso-de Faverney. Computational reconstruction of metabolic networks from KEGG / Tingting Zhou. Biomarkers / Harmony Larson [and others] Biomonitoring-based environmental public health indicators / Andrey I. Egorov, Dafina Dalbokova, and Michal Krzyzanowski. Modeling for regulatory purposes (risk and safety assessment) / Hisham El-Masri. Developmental toxicity prediction / Raghuraman Venkatapathy and Nina Ching Y. Wang. Predictive computational toxicology to support drug safety assessment / Luis G. Valerio Jr. Developing a practical toxicogenomics data analysis system utilizing open-source software / Takehiro Hirai and Naoki Kiyosawa. Systems toxicology from genes to organs / John Jack, John Wambaugh, and Imran Shah. Agent-based models of cellular systems / Nicola Cannata [and others] Linear algebra / Kenneth Kuttler. Ordinary differential equations / Jiří Lebl. On the development and validation of QSAR models / Paola Gramatica. Principal components analysis / Detlef Groth [and others] Partial least squares methods : partial least squares correlation and partial least square regression / Hervé Abdi and Lynne J. Williams. Maximum likelihood / Shuying Yang and Daniela De Angelis. Bayesian inference / Frederic Y. Bois.
  • 2009 Springer
    edited by C. Dishovsky and A. Pivovarov.
  • 2007 Springer
    John Harris Trestrail, III.
    Poisoners throughout history -- Types of poisons -- Poisoners -- Victims -- Crime scene investigation -- The forensic autopsy -- Proving poisoning -- Poisoners in court -- Poisoning in fiction -- Conclusion.
  • 1999- Wiley
    editorial board, Mahin D. Maines (editor-in-chief) ... [et al.].
  • v. 1-, 2012- Springer
    Archer, Trevor K.; Kostrzewa, Richard M.
    Consists of volumes that cover the latest developments in neurotoxicity studies including neurodegeneration, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.
  • 2006 CRCnetBASE
    David A. Dzombak, Rajat S. Ghosh, George M. Wong-Chong.
  • 2005 CRCnetBASE
    Ian R. Falconer.
  • 2005 CRCnetBASE
    edited by Koji Kawakami, Bharat B. Aggarwal, Raj K. Puri.
  • 2011 WHO
    Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
    Also available: Print – 2011
  • 2005 CRCnetBASE
    edited by Jim E. Riviere.
  • 2014 WHO
    Also available: Print – 2014
  • 2010 Springer
    edited by Mariapia Viola Magni.
    Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • 2005 CRCnetBASE
    Yin Sun, Kwok Y. Ong.
  • 2006 CRCnetBASE
    edited by Ronald D. Hood.
  • 2005 CRCnetBASE
    edited by Steven D. Holladay.
  • 2012 Springer Protocols
    edited by Craig Harris, Jason M. Hansen.
    In vivo models of developmental toxicology / Jason M. Hansen -- Caenorhabditis elegans as a model in developmental toxicology / Windy A. Boyd, Marjolein V. Smith, and Jonathan H. Freedman -- Zebrafish embryo developmental toxicology assay / Julieta M. Panzica-Kelly, Cindy X. Zhang, and Karen Augustine-Rauch -- Gene knockdown by morpholino-modified oligonucleotides in the Zebrafish (Danio rerio) model : applications for developmental toxicology / Alicia R. Timme-Laragy, Sibel I. Karchner, and Mark E. Hahn -- Amphibian model for studies of developmental reproductive toxicity / Cecilia Berg -- Avian models in teratology and developmental toxicology / Susan M. Smith, George R. Flentke, and Ana Garic -- Overview of in vitro models in developmental toxicology / Craig Harris -- Primary cell and micromass culture in assessing developmental toxicity / M. Pratten -- Embryonic stem cell test : stem cell use in predicting developmental cardiotoxicity and osteotoxicity / Beatrice Kuske, Polina Y. Pulyanina, and Nicole I. zur Nieden -- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay / Marianne Barrier [and others] -- Murine limb bud in culture as an in vitro teratogenicity test System / France-Helene Paradis, Chunwei Huang, and Barbara F. Hales -- Rodent whole embryo culture / Craig Harris -- Rabbit whole embryo culture / Valerie A. Marshall and Edward W. Carney -- Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example / Helen J. Renaud, Allison Rutter, and Louise M. Winn -- Methodological approaches to cytochrome P450 profiling in embryos / Jared V. Goldstone and John J. Stegeman -- Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos / Shao-yu Chen -- Regulation and control of AP-1 binding activity in embryotoxicity / Terence R.S. Ozolins -- Thioredoxin redox status assessment during embryonic development : the redox western / Jason M. Hansen -- Methods for the determination of plasma or tissue glutathione levels / Trent E. Tipple and Lynette K. Rogers -- Oxidative stress, thiols, and redox profiles / Craig Harris and Jason M. Hansen -- Review of toxicogenomic approaches in developmental toxicology / Joshua F. Robinson, Jeroen L.A. Pennings, and Aldert H. Piersma -- Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events / Elena Menegola, Graziella Cappelletti, and Francesca Di Renzo -- DNA methylation screening and analysis / Karilyn E. Sant, Muna S. Nahar, and Dana C. Dolinoy -- Assessment of histiotrophic nutrition using fluorescent probes / Jeffrey Ambroso and Craig Harris -- Diabetic embryopathy / Ulf J. Eriksson and Parri Wentzel -- Gene expression analysis in developing embryos : in situ hybridization / Siew-Ging Gong -- Assessment of gross fetal malformations : the modernized wilson technique and skeletal staining / Robert E. Seegmiller [and others].
  • 2012 Wiley
    edited by Arnold Schecter.
    Persistent organic pollutants : an overview / Daniele Wikoff, Lauren Fitzgerald, Linda Birnbaum Toxic equivalency factors (TEFS) for dioxin and related compounds / Michael DeVito Historic and newer persistent organic pollutants (POPS) in U.S. food / Janice Huwe -- Flame retardants : PBDES and their replacements / Thomas Webster, Heather Stapleton -- Pharmacokinetics of TCDD and related compounds / James Olson -- Immunomodulation by persistent organic pollutants / Robert Luebke [and others] -- Developmental neurotoxicity of dioxins / G. Jean Harry, Pamela J. Lein -- Epidemiological evidence on the health effects of perfluorooctanoic acid (PFOA) / Kyle Steenland, Tony Fletcher, David Savitz -- Polybrominated dibenzo-p-dioxins and dibenzofurans / Kurunthachalam Kannan, Chunyang Liao, Hyo-Bang Moon -- Epidemiological studies on cancer and exposure to dioxin and related compounds / Lennart Hardell, Mikeal Eriksson -- Reproductive and developmental epidemiology of dioxins -- Anne Sweeney [and others] -- Bisphenol A / Thaddeus Shug [and others] -- Phthalates : human exposure and related health effects / John D. Meeker, Kelly K. Ferguson -- The seveso accident / Angela Cecilia Pesatori, Pier Alberto Bertazzi -- Agent orange : long term health and environmental impact in Vietnam / Susan Hammond, Arnold Schecter -- The yusho and yucheng rice oil poisoning incidents / Yoshito Masuda, Arnold Schecter -- The Binghamtom New York electrical transformer fire incident of 1981 / Nancy Kim, Arnold Schecter -- The Yushchenko dioxin poisoning : chronology and pharmacokinetics / John Jake Ryan -- Human health risk assessment of POPS / David Szabo, Anne E. Loccisano.
  • 2009 ATSDR
    prepared by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2007 ATSDR
    U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2008 ATSDR
    prepared by Syracuse Research Corporation Under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2007 ATSDR
    U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2009 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2010 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2010
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract No. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2009 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2006 Springer
    H. Gerhard Vogel (ed.) ; Franz Jakob Hock, Jochen Maas, Dieter Mayer (co-editors).
    Section I, Safety pharmacology: -- Introduction to safety pharmacology -- Status of safety pharmacology and present guidelines -- Central nervous system (CNS) safety pharmacology studies -- Methods in cardiovascular safety pharmacology -- Safety pharmacology of drugs for the urinary tract -- Respiratory function assays in safety pharmacology -- Metabolism pharmacology -- Peripheral nervous system -- Safety of intravenous and inhalation anesthetics -- Side effects of central analgesic drugs -- Safety pharmacology of antiinflammatory drugs -- Safety pharmacology of drugs with osteoarthritis-related activity -- Safety pharmacology of blood constituents -- Ocular toxicity tests -- Assays in endocrine safety pharmacology -- Safety assays in skin pharmacology -- Magnetic resonance imaging in pharmaceutical safety assessment -- Section II, Safety pharmacokinetics: -- Introduction -- Physicochemical properties -- In-silico ADME modeling -- Absorption-in vitro tests-cell based -- Absorption-in vitro tests-non cell based -- Distribution-in vitro tests-protein binding -- Perfused organs -- Metabolism studies in vitro and in vivo -- Distribution-across barriers -- Drug-drug interaction-enzyme induction -- Drug-drug interaction-enzyme inhibition -- Absorption -- In vivo distribution -- Distribution-in vivo-other methods -- Bioanalytical assays-Toxicokinetics -- Bioanalytical assays-liquid chromatography coupled to tandem spectrometry -- Bioanalytical assays-gas chromatography -- Bioanalytical assays-RIA/EIA -- Clinical studies-typical designs -- Pharmacogenomics in DME -- Typical PK/PD approaches -- Population kinetics in drug development -- Section III, Safety toxicology: -- Introduction -- International guidelines for the development of pharmaceutical compounds -- General toxicity -- In silico methods -- Alternative methods for carcinogenicity testing -- Genotoxicity -- Reproductive toxicology -- Application of toxicoproteomics in profiling drug effects.
  • 2009 Springer Protocols
    edited by Jean-Charles Gautier.
    Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
  • 2008 Springer
    edited by Amanda J. Jenkins ; foreword by Yale H. Caplan.
  • 2013 ScienceDirect
    edited by Neil Kaplowitz and Laurie Deleve.
    I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
  • 2015
    Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    [edited by] Osamu Suzuki and Kanako Watanabe.
    I. Chapters of general nature. How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) -- Problems in toxin analysis in emergency medicine -- Analyses of chemical warefare agents and their related compounds -- B. Chapters on specific toxins. Volatile compounds -- Controlled drugs -- Psychopharmaceuticals and hypnotics -- General drugs -- Chemicals of daily necessaries -- Natural toxins and alkaloids -- Pesticides -- Miscellaneous.
  • 2006 Springer
    E. Granéli, J.T. Turner (eds.).
  • 2013 CRCnetBASE
    Richard B. Philp.
    "The third edition of a bestseller, this book describes how chemical toxins and biological hazards impact the environment and people. Addressing how pollutants can alter the environment by contributing to global climate change, the author explores a broad range of environmental and health aspects of chemical and biological hazards. He includes numerous examples of the intimate relationship between ecosystem health and human health and emphasizes the need to consider this relationship whenever human activities are likely to have a significant environmental impact"-- Provided by publisher.
  • 2008 CRCnetBASE
    Michael C. Newman, William H. Clements.
    I. Hierarchical ecotoxicology. The hierarchical science of ecotoxicology -- II. Organismal ecotoxicology. The organismal ecotoxicology context -- Biochemistry of toxicants -- Cells and tissues -- Organs and organ systems -- Physiology -- Bioaccumulation -- Models of bioaccumulation and bioavailability -- Lethal effects -- Sublethal effects -- Conclusion -- III. Population ecotoxicology. The population ecotoxicology context -- Epidemiology : the study of disease in populations -- Toxicants and simple population models -- Toxicants and population demographics -- Phenogenetics of exposed populations -- Population genetics : damage and stochastic dynamics of the germ line -- Population genetics : natural selection -- Conclusion -- IV. Community ecotoxicology. Introduction to community ecotoxicology -- Biotic and abiotic factors that regulate communities -- Biomonitoring and the responses of communities to contaminants -- Experimental approaches in community ecology and ecotoxicology -- Application of multimetric and multivariate approaches in community ecotoxicology -- Disturbance ecology and the responses of communities to contaminants -- Community responses to global and atmospheric stressors -- Effects of contaminants on trophic structure and food webs -- Conclusions -- V. Ecosystem ecotoxicology. Introduction to ecosystem ecology and ecotoxicology -- Overview of ecosystem processes -- Descriptive approaches for assessing ecosystem responses to contaminants -- The use of microcosms, mMesocosms, and field experiments to assess ecosystem responses to contaminants and other stressors -- Patterns and processes : the relationship between species diversity and ecosystem function -- Fate and transport of contaminants in ecosystems -- Effects of global atmospheric stressors on ecosystem processes -- VI. Ecotoxicology : a comprehensive treatment--conclusion -- Conclusion.
  • 2008 CRCnetBASE
    author, John R. Cashman.
  • 2005 Springer
    Hans-Werner Vohr (ed.).
  • 2015 Springer
    Roger G. Pertwee, editor.
    There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced ℓ́ℓautoprotectionℓ́ℓ, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose endocannabinoid-induced autoimpairment. This volume describes the physiology, pathophysiology and pharmacology of the endocannabinoid system and potential strategies for targeting this system in the clinic.
  • 2013 Springer
    Mary E. Abood, Roger G. Sorensen, Nephi Stella, editors.
    Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • 2014 Wiley
    Sushil K. Khetan.
    Environmental endocrine disruptors -- Part I. Mechanisms of hormonal action and putative endocrine disruptors. Mechanisms of endocrine system function -- Environmental chemicals targeting estrogen signaling pathways -- Anti-androgenic chemicals -- Thyroid-disrupting chemicals -- Activators of PPAR, RXR, AhR, and steriodogenic factor 1 -- Effects of EDC mixtures -- Environmentally induced epigenetic modifications and transgenerational effects -- -- Part II. Removal mechanisms of EDCs through biotic and abiotic processes. Biodegradations and biotransformations of selected examples of EDCs -- Abiotic degradations / transformations of EDCs through oxidation processes -- -- Part III. Screening and testiing for potential EDCs, implications for water quality sustainability, policy and regulatory issues, and green chemistry principles in the design of safe chemicals and remediation of EDCs. Screening and testing programs for EDCs -- Trace contaminants : implications for water quality sustainability -- Policy and regulatory considerations for EDCs -- Green chemistry principles in the designing and screening for safe chemicals and remediation of EDCs.
  • 2007 Springer
    edited by Andrea C. Gore.
  • 2011 Springer
    Jose Russo, editor.
    Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
  • 2005 ScienceDirect
    edited by T.P. Mommsen and T.W. Moon.
    The utility of zebrafish as a model for toxicological research / Michael J. Carvan III, Tisha King Heiden and Henry Tomasiewicz -- Use of fish cell lines in the toxicology and ecotoxicology of fish : piscine cell lines in environmental toxicology / N.C. Bols, V.R. Dayeh, L.E.J. Lee and K. Schirmer -- Approaches in proteomics and genomics for eco-toxicology -- Nancy D. Denslow, Iris Knoebl and Patrick Larkin -- Interactions between lipids and persistent organic pollutants in fish / Adria A. Elskus, Tracy K. Collier and Emily Monosson -- Metabolic fate of nonylphenols and related phenolic compounds in fish / Jean-Pierre Cravedi and Daniel Zalko -- Pesticide biotransformation in fish / Daniel Schlenk -- Xenobiotic receptors in fish : Structural and functional diversity and evolutionary insights / Mark E. Hahn, Rebeka R. Merson and Sibel I. Karchner -- Impacts of environmental toxicants and natural variables on the immune system of fishes / Karen G. Burnett -- Fish models of carcinogenesis / Gary K. Ostrander and Jeanette M. Rotchell -- Metallothionein : structure and regulation / Peter Kling and Per-Erik Olsson -- Cell death : investigation and application in fish toxicology / Antony W. Wood, David M. Janz and Glen J. Van Der Kraak -- Adrenal toxicology : environmental pollutants and the HPI axis / Alice Hontela -- Xenobiotic impact on corticosteroid signaling / Mathilakath M. Vijayan, Patrick Prunet and Adrienne N. Boone -- Thyroid hormones / J.G. Eales and S.B. Brown -- The biology and toxicology of retinoids in fish / D. Alsop, Glen J. Van Der Kraak, S.B. Brown and J.G. Eales -- Vitellogenesis and endocrine disruption / Naoshi Hiramatsu, Ann O. Cheek, Craig V. Sullivan, Takahiro Matsubara and Akihiko Hara -- Pharmaceuticals in the environment : drugged fish? / Vance L. Trudeau, Chris D. Metcalfe, Caroline Mimeault and Thomas W. Moon -- P-glycoproteins and xenobiotic efflux transport in fish / Armin Sturm and Helmut Segner.
  • 2008 Springer Protocols
    edited by Donna L. Mendrick, William B. Mattes.
    Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
  • 2014 Wiley
    Michael D. Coleman.
    A brief history of occupational toxicology -- The expert report process in legal context -- Acute toxicity : case histories of solvent exposure -- Chronic and permanent injury : bladder cancer and occupation -- Chronic and acute toxicity of herbicides and pesticides -- Toxicity of imported goods.
  • 2010 Springer
    I. Mader, P.R. Fürst-Weger, R.M. Mader, E. Nogler-Semenitz, S. Wassertheurer.
  • 2011
    Jennifer Ann Dougherty.
    The contamination of water supplies by organic contaminants such as pharmaceuticals and personal care products (PPCPs) pose a potential risk to the health of humans and ecosystems. Septic systems under the best circumstances produce effluent quality equivalent to biologically or secondarily treated wastewater, which is known to be inefficient for removal of many PPCPs. This dissertation examines septic systems as a source of PPCP pollution. The occurrence, fate, and transport of a set of 25 organic contaminants commonly found in wastewater was studied at the scale of a watershed, a septic system, and in microcosms that simulated the geochemical conditions of a septic plume. The septic system study was carried out at Stinson Beach, CA and the watershed study at Liberty Bay, WA. The tested compounds included 19 pharmaceuticals, three personal care products, two herbicides and one flame retardant. They encompassed a structurally diverse group of chemicals with a wide range of physicochemical properties, with Log Kow ranging -0.07 to 4.77 as well as acidic and basic properties. First, sediments from Stinson Beach, CA were used in batch microcosm experiments to assess biotransformation and sorption under conditions simulating an aerobic groundwater system and the nitrate and sulfate reducing conditions of a septic plume. Transformation was found, in general, to be slower under anaerobic conditions than aerobic conditions. Half-lives ranged from 4 days to longer than 365 days for all conditions. Sorption did not fit the commonly used hydrophobic models governed by Log Kow, indicating the significance of factors other than hydrophobicity. These factors may include hydrogen bonding and electrostatic attraction due to one or several polar functional groups. Second, the occurrence and transport of PPCPs in a single septic system along the California coast was documented. Findings indicated that many PPCPs were refractory and mobile under the conditions of a leach field contaminant plume. Finally, in a watershed scale study in Liberty Bay, Washington, the occurrence of PPCPs thought to originate from septic systems was evaluated. The findings are consistent with laboratory data and usage patterns. The overall results of this dissertation suggest that septic systems, which support 25% of the United States population, may be a significant source of PPCP contamination to groundwater and surface waters.
  • 2007 Springer
    edited by Shabbir Simjee ; foreword by Toni L. Poole.
    Escherichia coli / Jianghong Meng and Carl M. Schroeder -- Listeria / Franz Allerberger -- Clostridium botulinum and Clostridium perfringens / Jim McLauchlin and Kathie A. Grant -- Yersinia enterocolitica and Yersinia pseudotuberculosis / Maria Fredriksson-Ahomaa -- Foodborne pathogenic vibrios / T. Ramamurthy and G. Balakrish Nair -- Enterococcus and its association with foodborne illness / Simona F. Oprea and Marcus J. Zervos -- Foodborne viral hepatitis / Hazel Appleton ... [et al.] -- Gastroenteric virus / Miren Iturriza-Gómara, Chris I. Gallimore, and Jim Gray -- Cryptosporidium / Huw V. Smith -- Toxoplasma gondii / Dolores E. Hill ... [et al.] -- Aflatoxins : background, toxicology, and molecular biology / Joan W. Bennett, S. Kale, and Jiujiang Yu -- Scombroid fish poisoning / Elijah W. Stommel -- Pathogen control in meat and poultry production: implementing the USDA food safety and inspection service's hazard analysis and critical control point system / Moshe S. Dreyfuss ... [et al.] -- Use of antimicrobials in food animal production / Frank M. Aaestrup and Lars B. Jensen -- Alternatives to antimicrobials* / Toni L. Poole, Todd R. Callaway, and David J. Nisbet -- Microbial risk assessment / Carl M. Schroeder -- Food irradiation and other sanitation procedures / Donald W. Thayer -- Molecular techniques of detection and discrimination of foodborne pathogens and their toxins / Steven L. Foley and Kathie A. Grant -- Future directions in food safety* / Ross C. Beier and Suresh D. Pillai.
  • 2006 IARC
    Also available: Print – 2006
  • 2013 Springer
    Ijeoma F. Uchegbu, Andreas G. Schätzlein, Woei Ping Cheng, Aikaterini Lalatsa, editors.
    Nanoscience and nanotechnology overview -- Liposome preparation and characterization -- Solid polymeric nanoparticles -- Lipid nanoparticles -- Polymeric vesicles -- Low molecular weight amphiphile micelles -- Polymeric micelles -- Niosomes -- Quantum dots -- Magnetic particles -- Drug nanoparticles -- Polymeric pro-drugs -- Therapeutic Applications of pharmaceutical nanosystems -- Drug solubilisation -- Gene therapy -- Chemotherapy -- Tissue engineering -- Anti-infectives -- Vaccination -- Anti-arthritic drugs -- Imaging agents -- Commercial exploitation of pharmaceutical nanosystems -- Future perspectives -- Multiple Choice -- Problem Sets -- Case Studies -- Suggested Reading.
  • 2015 Springer Protocols
    edited by Duarte Miguel F. Prazeresl, Sofia Aires M. Martins.
    G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins -- Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others] -- Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others] -- Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer -- cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others] -- Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst -- Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith -- Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner -- Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah -- GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas -- Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres -- Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others] -- Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others] -- Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis -- Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others] -- Label-free functional selectivity assays / Ann M. Ferrie [and others] -- Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl -- Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others] -- Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].
  • 2012 Springer Protocols
    edited by James M. Parry and Elizabeth M. Parry.
    The application of structure-activity relationships to the prediction of the mutagenic activity of chemicals / Philip Judson -- Bacterial mutagenicity assays : test methods / David Gatehouse -- The mouse lymphoma assay / Melvyn Lloyd and Darren Kidd -- Mammalian cell HPRT gene mutation assay : test methods / George E. Johnson -- The in vitro mammalian chromosome aberration test / Gill Claire -- The interpretation and analysis of cytogenetic data / Natalie Danford -- The in vitro micronucleus assay / Ann T. Doherty -- The in vitro and in vivo comet assays / Brian Burlinson -- Assessment of DNA interstrand crosslinks using the modified alkaline comet assay / Jian Hong Wu and Nigel J. Jones -- 32P-postlabelling for the sensitive detection of DNA adducts / Nigel J. Jones -- Methods for the detection of DNA adducts / Karen Brown -- The GADD45a-GFP GreenScreen HC assay / Richard M. Walmsley and Matthew Tate -- Real-time reverse-transcription polymerase chain reaction : technical considerations for gene expression analysis / Shareen H. Doak and Zoulikha M. Zaïr -- Cytogenetic in vivo assays in somatic cells / Ann T. Doherty, Adi Baumgartner, and Diana Anderson -- Cytogenetic methods in human biomonitoring : principles and uses / Raluca A. Mateuca, Ilse Decordier, and Micheline Kirsch-Volders -- The measurement of induced genetic change in mammalian germ cells / Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo -- Transgenic animal mutation models : a review of the models and how they function / Steve Dean -- Analysis of genotoxicity data in a regulatory context / Ian de G. Mitchell and David O.F. Skibinski.
  • 2007 CRCnetBASE
    edited by William H. Benson and Richard T. Di Giulio.
    "Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
  • 2008 CRCnetBASE
    edited by Gerald T. Ankley ... [et al.].
    Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.]. Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
  • 2014 Springer Protocols
    edited by L. María Sierra, Isabel Gaivão.
    Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
  • 2013 Springer Protocols
    edited by Alok Dhawan, Mahima Bajpayee.
    Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
  • 2013 Springer
    Jan Willem van der Laan, Joseph J. DeGeorge, editors.
    The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
  • 2015 AccessEmergency Medicine
    [edited by] Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S. Nelson, Lewis R. Goldfrank ; editor emeritus Neal E. Flomenbaum.
    Pt. A: The general approach to medical toxicology -- Pt. B: The fundamental principles of medical toxicology -- Sect. I: Biochemcial and molecular basis -- Sect. II: Pathophysiologic basis: organ systems -- Sect. III: Special populations -- Pt. C: The clinical basis of medical toxicology -- Sect. I: A: Analgesics and antinflammatory medications -- B: Food, diet, and nutrition -- C: Pharmaceuticals -- D: Antimicrobials -- E: Cardiopulmonary medications -- F: Anesthetics and related medications -- G: Psychotropics -- H: Substances of abuse -- I: Metals -- J: Household products -- K: Pesticides -- L: Natural toxins and envenomations -- M: Occupational and environmental toxins -- N: Disaster preparedness -- Sect. II: Poison centers and epidemiology.
  • 2012 Springer
    Denis J. Dupré, Terence E. Hébert, Ralf Jockers, editors.
    ER-bound steps in the biosynthesis of G protein-coupled receptors / Christian Nanoff and Michael Freissmuth -- Role of chaperones in G Protein coupled receptor signaling complex assembly / Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- GPCR oligomerization: contribution to receptor biogenesis / Kathleen Van Craenenbroeck -- The functional size of GPCRs: monomers, dimers or tetramers? / Darlaine Pétrin and Terence E. Hébert -- Regulation of post-Golgi traffic of G protein-coupled receptors / Guangyu Wu -- Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- Regulatory processes governing the cell surface expression of LH and FSH receptors / Deborah L. Segaloff -- Chaperone-mediated assembly of G protein complexes / Barry M. Willardson and Christopher M. Tracy -- Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / Jane Dingus and John D. Hildebrandt -- Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / Janet D. Robishaw -- G Protein trafficking / Philip B. Wedegaertner -- Differential assembly of GPCR signaling complexes determines signaling specificity / Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- GPCR and voltage-gated calcium channels (VGCC) signaling complexes / Christophe Altier -- Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
  • 2007
    [edited by] Michael W. Shannon, Stephen W. Borron, Michael J. Burns.
    Status: Not Checked OutLane Catalog Record
  • 2015 Wiley
    edited by Raymond D. Harbison, Marie M. Bourgeois, and Giffe T. Johnson.
  • 2014 Wiley
    editors, Saura C. Sahu, Daniel A. Casciano.
  • 2015 CRCnetBASE
    edited by Bengt Fadeel.
    1. Nanomedicine(s) and their regulation / Ruth Duncan -- 2. Nanotoxicology : focus on nanomedicine / Helinor Johnston, Ali Kermanizadeh, and Vicki Stone -- 3. Nanomaterial characterization for toxicity testing / David B. Warheit and Christie M. Sayes -- 4. The synthetic and biological identities of nanomaterials / Bengt Fadeel and Wolfgang J. Parak -- 5. Nanotoxicology : the case for in vitro tests / Thomas Hartung -- 6. Nanotoxicology : the case for in vivo studies / David Y. Lai and David B. Warheit -- 7. Predictive nanotoxicology : in silico approaches / Enrico Burello -- 8. Physiologically based nanomaterial pharmacokinetic models / Jim E. Riviere -- 9. Immunotoxicity of nanomaterials / Barbara Lettiero, Z. Shadi Farhangrazi, and S. Moein Moghimi -- 10. Complement activation by nanomaterials / Janos Szebeni -- 11. Biodegradation of carbon-based nanomaterials / Cyrill Bussy, Alberto Bianco, Maurizio Prato, and Kostas Kostarelos -- 12. Genotoxicity and carcinogenicity of nanomaterials / Kee Woei Ng, Yun Zhao, Mustafa Hussain Kathwala, Sijing Xiong, Chit Fang Cheok, and Say Chye Joachim Loo -- 13. Pulmonary and cardiovascular toxicity of nanomaterials / Flemming R. Cassee and Vincent Castranova -- 14. Neurotoxicity of nanomaterials / Hari Shanker Sharma and Aruna Sharma -- 15. Dermatotoxicity of nanomaterials / Nancy A. Monteiro-Riviere and Jim E. Riviere -- 16. Reproductive toxicity of nanomaterials / Margaret Saunders, Gary Hutchison, and Sara Correia Carreira -- 17. Nanomedicine : ethical considerations / Todd Kuiken.
  • 2009 ScienceDirect
    edited by Ramesh C. Gupta.
  • 2014 CRCnetBASE
    edited by Michael J. Derelanko, Carol S. Auletta.
    "This third edition of a classic volume contains contributions from experts who provide both fundamental and applied information. Providing a fresh perspective on several topics, this edition contains completely rewritten chapters on immunotoxicology and endocrine, reproductive, and developmental toxicology. Chapters on neurotoxicology, and inhalation and regulatory toxicology have been updated and consolidated. The format of the book is designed to allow working toxicologists to locate basic information quickly. A separate glossary is included with terms presented both alphabetically and by toxicological subspecialty"--Provided by publisher.
  • 2013 ScienceDirect
    2013 ClinicalKey
    edited by Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon, Ricardo Ochoa ; Beth W. Mahler (illustrations editor).
  • v. 1-2, 2010 ScienceDirect
    edited by Robert I. Krieger.
    The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
  • 2003 CRCnetBASE
    Margaret-Ann Armour.
  • 2003 CRCnetBASE
    Robert Burke.
  • 2005 NAP
    Committee to Assess the Health Implications of Perchlorate Ingestion, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies.
  • 2014 CRCnetBASE
    James T. Tweedy, MS, CHSP, CPSO, CHEP, CHCM.
  • 2015 ScienceDirect
    Meenakshisundaram Ramachandran, editor ; P. Thirumalaikolundusubramanian, assistant editor.
    Epidemiology of cardiovascular toxins / Churchill Lukwiya Onen -- Cellular and molecular perspectives on cardiac toxins / Reza Tabrizchi -- Environmental toxins and the heart / Sahand Rahnama-Moghadam, L. David Hillis, and Richard A. Lange -- Problems and paradoxes of animal toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Plant toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Native medicines and cardiovascular toxicity / Ashish Bhalla, [et al.] -- Cardiovascular toxicity from marine envenomation / Benjamin Seymour, Athena Andreosso, and Jamie Seymour -- Cardiovascular toxicity of cardiovascular drugs / Ramachandran Meenakshisundaram, [et al.] -- Cardiovascular toxicity as a result of psychotropic drugs / Mythily Subramaniam, [et al.] -- Cardiovascular toxicity of noncardiovascular drugs / Omi Bajracharya, P. Ravi Shankar, and Nisha Jha -- Cardiovascular toxicity from chemotherapy and anticancer treatment / Angela Esposito, [et al.] -- Association of human immunodeficiency virus infection with exposure to highly active antiretroviral therapy and its adverse cardiovascular effects / Steven E. Lipschultz, [et al.] -- Toxic effects of alcohol on the heart / Subroto Acharjee, Bhaskar Purushottam, and Vincent M. Figueredo -- The effects of active and passive smoking and cardiovascular disease / Mahmood Ahmad, Emmanuel Selvaraj, and Ramachandran Meenakshisundaram -- Cardiovascular toxicity as a result of recreational drugs / Rohin Francis and Azad Ghuran -- Pediatric cardiovascular toxicity : special considerations / Jennifer A. Lowry -- Cardiovascular toxicity as a result of radiological imaging / Shah Sweni, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Nanomaterials and cardiovascular toxicity / Arghya Paul, [et al.] -- Forensic pathology related to cardiovascular toxicity / Magdy A. Kharoshah, [et al.] -- Ethics, legality, and education in the practice of cardiology / Ponniah Thirumalakolundusubramanian, Ramachandran Meenakshisundaram, and Subramanian Senthilkumaran.
  • 2013 Wiley
    edited by Pablo Steinberg.
    pt. 1. General aspects -- pt. 2. High-throughput assays to assess different cytotoxicity endpoints -- pt. 3. High-throughput assays to assess DNA damage and carcinogenesis -- pt. 4. High-throughput assays to assess reproductive toxicity, cardiotoxicity, and haematotoxicity -- pt. 5. High-throughput assays to assess drug metabolism and receptor-related toxicity.
  • 2009
    Lucile Packard Children's Hospital.
    Status: Not Checked OutLane Catalog Record
  • 2007 CRCnetBASE
    James L. Schardein & Orest T. Macina.
  • 2011 ScienceDirect
    Harold Zeliger.
    In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog). A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists. . New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures.
  • 2013 Springer
    Hideo Kimura, editor.
    The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900s. Three enzymes, cystathionine synthase (CBS), cystathionine lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
  • 2012 Springer
    K.D. Rainsford.
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • 2011 Thieme Book
    edited by Franz-Xaver Reichl, MD, Professor, Department of Operative/Restorative Dentistry, Periodontology, and Pedodontics, Ludwig Maximilian University, Munich, Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Germany, Leonard Ritter, MD, Professor, School of Environmental Sciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada ; with contributions by Jochen Benecke [and thirteen others].
    This book serves as a hands-on guide to various poison treatments and offers supplemental public health information. Each two-page unit features concise text on the left complemented by full-color illustrations on the opposing page. The expert author distinguishes harmful toxic substances and catalogues their specific effects on the human body, plants, animals, and the surrounding environment. The handbook also addresses other topics, including biological warfare, modern toxicological methods, and threshold values. Features include: succinct, user-friendly organization so readers can navigate the content with ease; over 600 detailed images and diagrams arranged on 150 full-color plates illustrate exposures and toxicological effects on humans, plants, and animals; well-researched, objective risk analysis on toxic exposures accompanied by relevant images; extensive glossary of key toxicological terms that provide readers with the accurate information they need to avoid dangerous confusion.
  • 2007 CRCnetBASE
    edited by Jeanette M. van Emon.
    Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • v.1, 2004 ScienceDirect
    J. Descotes.
    v. 1. Principles and methods of immunotoxicology.
  • 2011 Springer Protocols
    edited by Lucio G. Costa, Gennaro Giordano, Marina Guizzetti.
    In vitro neurotoxicology : an introduction / Lucio G. Costa, Gennaro Giordano, and Marina Guizzetti -- Primary neurons in culture and neuronal cell lines for in vitro neurotoxicological studies / Gennaro Giordano and Lucio G. Costa -- Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary cultures / Evelyn Tiffany-Castiglioni [and others] -- Microglia cell culture: a primer for the novice / Anke Witting and Thomas Möller -- Neural stem cells for developmental neurotoxicity studies / Roshan Tofighi [and others] -- Preparation, maintenance, and use of serum-free aggregating brain cell cultures / Paul Honegger [and others] -- Neurospheres as a model for developmental neurotoxicity testing / Ellen Fritsche, Kathrin Gassmann, and Timm Schreiber -- Acute hippocampal slice preparation and hippocampal slice Cultures / Pamela J. Lein, Christopher D. Barnhart, and Isaac N. Pessah -- Glia-neuron sandwich cocultures : an in vitro approach to evaluate cell-to-cell communication in neuroinflammation and neurotoxicity / ariaserena Boraso and Barbara Viviani -- In vitro models to study the blood brain barrier / Hilary Vernon, Katherine Clark, and Joseph P. Bressler -- Measurements of cell death in neuronal and glial cells / Gennaro Giordano [and others] -- Measurements of neuronal apoptosis / Gennaro Giordano and Lucio G. Costa -- Measurement of isoprostanes as markers of oxidative stress / Dejan Milatovic, Thomas J. Montine, and Michael Aschner -- Assessment of glutathione homeostasis / Gennaro Giordano, Collin C. White, and Lucio G. Costa -- Assessing neuronal bioenergetic status / Stephanie L.H. Zeiger, Jeannette N. Stankowski, and BethAnn McLaughlin -- Fluorescent assessment of intracellular calcium in individual cells / David P. Cox, Collin C. White, and Terrance J. Kavanagh -- Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures / Victor Briz and Cristina Suñol -- Detection of nitric oxide formation in primary neural cells and tissues / Ronald B. Tjalkens, David L. Carbone, and Guoyao Wu -- JNK3-mediated apoptotic cell death in primary dopaminergic neurons / Won-Seok Choi, Heather M. Klintworth, and Zhengui Xia -- Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration / Faneng Sun, Anumantha G. Kanthasamy, and Arthi Kanthasamy -- Cell signaling and neurotoxicity : protein kinase C in vitro and in vivo / Prasada Rao S. Kodavanti -- Cell signaling and neurotoxicity : 3H-arachidonic acid release (phospholipase A2) in cerebellar granule neurons / Prasada Rao S. Kodavanti -- Quantitative assessment of neurite outgrowth in PC12 cells / Joshua A. Harrill and William R. Mundy -- Measurements of astrocyte proliferation / Marina Guizzetti, Terrance J. Kavanagh, and Lucio G. Costa -- Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons / Pamela J. Roqué [and others] -- Volume measurements in cultured primary astrocytes / Michael Aschner -- Assessment of cholesterol homeostasis in astrocytes and neurons / Jing Chen, Lucio G. Costa, and Marina Guizzetti -- Dose-response or dose-effect curves in in vitro experiments and their use to study combined effects of neurotoxicants / Matteo Goldoni and Sara Tagliaferri.
  • 2014 Springer Protocols
    edited by Anna Bal-Price, Paul Jennings.
    In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
  • 2009 ScienceDirect
    edited by Philip Wexler ; associate editors, Steven G. Gilbert, Pertti J. Hakkinen, Asish Mohapatra.
  • 2010 IARC
    Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
    Also available: Print – 2010
  • 2006 CRCnetBASE
    edited by Harry Salem, Sidney A. Katz.
    Also available: Print – 2006
  • 2015 CRCnetBASE
    edited by Harry Salem, Sidney A. Katz.
    Chapter 1. Collection and characterization of particulate matter deposition / Gregor Jereb, Sidney A. Katz, and Borut Poljésak -- chapter 2. Nose-only aerosol exposure systems : design, operation, and performance / Robert F. Phalen, Loyda B. Mendez, and Michael J. Oldham -- chapter 3. Lungs-on-a-chip / Shuichi Takayama, Joshua B. White, and Chao Zhang -- chapter 4. Human health risk assessment of inhaled materials / Rhian B. Cope, Patricia Nance, and Mike Dourson -- chapter 5. Application of inhalation toxicology concepts to risk and consequence assessments / Brian E. Hawkins, David J. Winkel, Patrick H. Wilson, and Ian C. Whittaker -- chapter 6. Time scaling of dose and time to response : the toxic load exponent / Juergen Pauluhn -- chapter 7. Improper use of Haber's Law results in erroneous fatality estimation from predictive models / Tom Ingersoll, Janet Moser, Douglas R. Sommerville, and Harry Salem -- chapter 8. Physiologically based kinetic modeling of inhalation / Harvey J. Clewell III, Jeffry D. Schroeter, and Melvin E. Andersen -- chapter 9. Nanomaterial inhalation exposure from nanotechnology-based consumer products / Yevgen Nazarenko, Paul J. Lioy, and Gediminas Mainelis -- chapter 10. Influence of physicochemical properties on the bioactivity of carbon nanotubes/nanofibers and metal oxide nanoparticles / Dale W. Porter and Vincent Castranova -- chapter 11. Inhalation toxicology of riot control agents / Harry Salem, Michael Feasel, and Bryan Ballantyne -- chapter 12. Incapacitating agents / Joseph L. Corriveau and Michael Feasel -- chapter 13. Exposure to ammonia / Finis Cavender and Glenn Milner -- chapter 14. Serpentine and amphibole asbestos / David M. Bernstein -- chapter 15. Pulmonary primary cells cocultured in a novel cell culture system, the integrated discrete multiple cell-type coculture system (IdMOC) : pulmonary cytotoxicity of eight cigarette smoke condensates and nicotine / Albert P. Li, Patricia Richter, Stephanie Cole, Janna Madren- Whalley, Jonathan Oyler, Russell Dorsey, and Harry Salem -- chapter 16. Animal models of chronic obstructive pulmonary disease (COPD) / Steven G. Kelsen -- chapter 17. Toxic inhalation injury : management and medical treatment / Arik Eisenkraft and Avshalom Falk -- Chapter 18. Transcriptomic responses to crystalline silica exposure / Pius Joseph, Christina Umbright, and Rajendran Sellamuthu -- chapter 19. Mechanisms involved in the inhalation toxicity of phosgene / Wenli Li and Juergen Pauluhn -- chapter 20. Chemical warfare agents and nuclear weapons / Terry J. Henderson, Nabil M. Elsayed, and Harry Salem -- chapter 21. Emergency response planning guidelines / Finis Cavender -- ch. 22. Safety assessment of therapeutic agents administered by the respiratory routes / Shayne C. Gad.
  • 2006 IARC
    IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
    Also available: Print – 2006
  • 2013 WHO
    Sheffer, Marla.
    Also available: Print – 2013
  • 2008 CRCnetBASE
    D. Jesse Wagstaff.
  • 2003 CRCnetBASE
    edited by Michael E. Burczynski.
  • 2014 Springer
    Philip C. Burcham.
    This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960?s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that "unpack" the concepts being discussed in the text.
  • 2005 CRCnetBASE
    edited by Helen Tryphonas, Michel Fournier, Barry R. Blakley ... [et al.].
    Also available: Print – 2005
  • 2007 WHO
    IPCS.
    The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
    Also available: Print – 2007
  • 2007 NLM
    prepared for publication by John H. Duffus, Monica Nordberg, Douglas M. Templeton.
  • 2011 CRCnetBASE
    edited by Mark L. Witten, Errol Zeiger, Glenn D. Ritchie.
    Air Force-related jet fuel toxicology research (1991-2010) / Walter J. Kozumbo -- Jet fuel composition / Tim Edwards -- The toxicity and underlying mechanism of jet propulsion fuel-8 on the respiratory system / Simon S. Wong and Mark L. Witten -- Neurotoxicological and neurobehavioral effects from exposure to jet fuels / Glenn D. Ritchie -- Differential protein expression following JP-8 jet fuel exposure / Frank A. Witzmann and Mark L. Witten -- Immune modulation by dermal exposure to jet fuel / Gerardo Ramos and Stephen E. Ullrich -- Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components / James E. Riviere, Alfred O. Inman, and Nancy Monteiro-Riviere -- Methods of assessing skin irritation and sensitization of jet fuels / R. Jayachandra Babu, Ram Patlolla, and Mandip Singh -- Understanding systemic and local toxicity of JP-8 after cutaneous exposures / James N. McDougal, James V. Rogers, and Richard Simman -- The effects of aerosolized JP-8 jet fuel exposure on the immune system: a review / David T. Harris -- The involvement of poly(ADP-ribosyl)ation in defense against JP-8 jet fuel and other chemical toxicants / Luis A. Espinoza ... [et al.] -- Evaluation of methods used to generate and characterize jet fuel vapor and aerosol for inhalation toxicology studies / Raphaël T. Tremblay, Sheppard A. Martin, and Jeffrey W. Fisher -- Genetic damage in the blood and bone marrow of mice treated with JP-8 jet fuel / Vijayalaxmi -- Computational analyses of JP-8 fuel droplet and vapor depositions in human upper airway models / Clement Kleinstreuer and Zhe Zhang -- Human exposure to Jet Propellant-8 / Raymond H. Tu and Terence H. Risby.
  • 2014 CRCnetBASE
    editor, Sang Geon Kim.
    "This book bridges the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments. 10 chapters describe major areas of progress in the laboratory and clinic. In the first section, the aspects of cellular organelles are discussed. In the second, the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches are covered. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally the clinical implications for the understanding of acute and chronic renal toxicity are studied"--Provided by publisher.
  • 2012 Springer Protocols
    edited by Bernhard Kuster.
    Targeting cancer with small-molecular-weight kinase inhibitors / Doriano Fabbro [and others] -- Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation / Matthias Gaestel and Alexey Kotlyarov -- Measuring the activity of leucine-rich repeat kinase 2 : a kinase involved in Parkinson's disease / Byoung Dae Lee [and others] -- Measuring P13K lipid kinase activity / Elisa Ciraolo, Alessia Perino, and Emilio Hirsch -- A fluorescence polarization assay for the discovery of inhibitors of the polo-box domain of polo-like kinase 1 / Wolfgang Reindl, Klause Strebhardt, and Thorsten Berg -- Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology / Jinghai J. Xu [and others] -- Kinase inhibitor selectivity profiling using differential scanning fluorimetry / Oleg Fedorov, Frank H. Niesen, and Stefan Knapp -- Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP / James S. Duncan, Timothy A.J. Haystead, and David W. Litchfield -- Proteome-wide identification of staurosporine-binding kinases using capture coumpound mass spectrometry / Jenny J. Fischer, Olivia Y. Graebner (neé Baessler), and Mathias Dreger -- Affinity pruification of proteins binding to kinase inhibitors immobilized on self-assembling monolayers / Marcus Bantscheff, Scott Hobson, and Bernhard Kuster -- Kinase inhibitor profiling using chemoproteomics / Markus Schirle [and others] -- Covalent cross-linking of kinases with their corresponding peptide substrates / Alexander V. Statsuk and Kevan M. Shokat -- Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays / Oliver Pötz [and others] -- Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays / Gabriela Lavezzari and Mark R. Lackner -- Measuring phosphorylation-specific changes in response to kinase inhibitors in mammalian cells using quantitative proteomics / Nurhan Özlü, Marc Kirchner, and Judith Jebanathirajah Steen -- Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays / Kian Kani, Rafaella Sordella, and Parag Mallick.
  • NLM
    Includes workbook: TOXNET & Beyond-- Using the National Library of Medicine® Environmental Health & Toxicology Portal.
  • 2015 Springer
    Raymond Chuen-Chung Chang, Kwok-Fai So, editors.
    1. Chemical and genetic diversity of Wolfberry -- 2. Immunoregulation and Lycium Barbarum -- 3. The antioxidant, anti-inflammatory, and antiapoptotic effects of Wolfberry in fatty liver disease -- 4. Effectts of Lycium barbarum on modulation of blood vessel and hemodynamics -- 5. Dermatologic uses and effects of Lycium barbarum -- 6. Lycium Barbarum and tumors in the gastrointestinal tract -- 7. Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum -- 8. Prosexual effects of Lycium Barbarum -- 9. Lycium Barbarum: neuroprotective effects in ischemic stroke -- 10. Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium Barbarum (Wolfberry) -- 11. Role of Lycium Barbarum extracts in retinal diseases -- 12. Allergenic sensitisation mediated by Wolfberry.
  • v. 1-2, 2014 Springer
    v. 2 Springer
    Bernd Nilius, Veit Flockerzi, editors.
    v. 1. TRPs: truly remarkable proteins -- The TRCP subfamily -- TRPC1 -- TRPC2 -- TRPC3: a multifunctional signaling molecule -- TRPC4 and TRPC4-containing channels -- TRPC5 -- TRPC6: physiological function and pathophysiological relevance -- Transient receptor potential canonical 7 (TRPC7) -- The TRPV subfamily -- TRPV1 -- TRPV2 -- TRPV3 -- The TRPV4 channel -- TRPV5, a Ca2+ channel for the fine tuning of Ca2+ reabsorption -- TRPV6 channels -- The TRPM subfamily -- TRPM1 -- TRPM2 -- TRPM3 -- TRPM4 -- TRPM5 -- TRPM6 -- TRPM7 -- TRPM8 -- The TRPA1, TRPML and TRPP subfamily -- TRPA1 -- TRPML1: an ion channel in the lysosome -- TRPML2 and mucolipin evolution -- TRPML3 -- TRPP subfamily and polycystin-1 proteins -- v. 2. TRPs as special cell sensors -- Temperature sensing with TRPs -- TRPs in mechano-sensing and volume regulation -- TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) -- Photosensitive TRPs -- TRPs in taste and chemesthesis -- TRPs and Pain -- TRPs in hearing -- TRPs in olfaction -- General topics -- Evolutionary conserved, multitasking TRP channels-lessons from worms and flies -- Structural biology of TRP channels -- High-resolution views of TRPV1 and their implications for the TRP channel superfamily -- Physiological functions and regulation of TRPC channels -- The TRPCs-STIM1-orai interaction -- The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins -- TRPs: modulation by drug-like compounds -- TRP channels in reproductive (neuro)endocrinology -- Modulation of TRP ion channels by venomous toxins -- Phosphoinositide regulation of TRP channels -- TRP modulation by natural compounds -- What do we really know and what do we need to know: some controversies, perspectives, and surprises.
  • 2016 Springer
    Rudolph M. Navari, editor.
    1. Introduction -- 2. The physiology and pharmacology of nausea and vomiting induced by anticancer chemotherapy in humans -- 3. First-generation 5-HT3 receptor antagonists -- 4. Palonosetron -- 5. The role of neurokinin-1 receptor antagonists in CINV -- 6. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting -- 7. Gabapentin for the prevention of CINV -- 8. Prevention of CINV in patients receiving high-dose multiple-day chemotherapy -- 9. Clinical management of CINV -- 10. Treatment of chemotherapy-induced nausea -- 11. Conclusions -- 12. Future directions.
  • 2008 CRCnetBASE
    edited by Hongbo Zhai, Klaus-Peter Wilhelm, Howard I. Maibach.
    Evaluting efficacy of barrier creams: in vitro and in vivo models -- Light-induced dermal toxicity: effects on cellular and molecular levels -- Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products -- Exogenous ochronosis: update -- Diagnostic patch test: science and art -- Irritant and allergic contact dermatitis treatment -- Factors affecting children's susceptibility to chemicals -- Utilization of irritation data in local lymph node assay -- Air bag injuries -- Cigarette smoking and skin -- Chemical analysis of tattoo pigments cleaved by laser light -- Dermatotoxicology of specialized epithelia: adapting cutaneous test methods to assess topical effects on vulva -- Anti-irritants: myth or reality? overview -- Evaluating mechanical and chemical irritation using the behind-the-knee tests: review -- Need for more sensitive tools as we reach limits of our ability to detect differences in skin effects from mild products -- Drug patch testing in systemic cutaneous drug allergy -- Hormesis and dermatology -- Diagnosis of drug hypersensitivity in vitro -- Immunologic patterns in allergic and irritant contact dermatitis: similarities -- Water decontamination of chemical skin and eye splashes: critical review -- Chemical substances and contact allergy: 244 substances ranked according to allergenic potency -- Use of modified forearm controlled application test to evaluate skin irritation of lotion formulations -- Hair in toxicology -- Popliteal lymph node assay -- Pigmentation changes resulting from arsenic exposure -- Textiles and human skin, microclimate, cutaneous reactions: overview -- In vivo human transfer of topical bioactive drugs among individuals: estradiol -- Is there evidence that geraniol causes allergic contact dermatitis? -- Operational definition of a causative contact allergen-study with six fragrance allergens -- Sodium lauryl sulfate-induced irritation in human faces: regional- and age-related differences -- Classification of irritant contact dermatitis -- In vitro skin irritation testing on SkinEthic[tm]-reconstituted human epidermis: reproducibility for fifty chemicals tested with two protocols -- Identifying source of textile-dye allergic contact dermatitis: guidelines -- Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate -- Is contact allergy lifelong in humans? an overview of patch-test follow-ups -- Irritants in combination with synergistic or additive effect on skin response overview of tandem irritation studies -- Allergic contact dermatitis from iodine preparations: a conundrum? -- Human skin buffering capacity: oveview. Pesticide percutaneous absorption and decontamination -- Tape stripping method versus stratum corneum -- Parameters influencing stratum corneum removal by tape stripping -- Quantification of stratum corneum removed by tape stripping -- Isolated perfused porcine skin flap -- Physiologically based pharmacokinetic modeling -- Methods for in vitro skin metabolism studies -- Predicitive toxicology methods for transdermal delivery systems -- Animal, human, and in vitro test methods for predicting skin irritation -- Kawaki method for testing irritation -- Analysis of structural change in intercellular lipids of humam stratum corneum induced by surfactants: electron paramagnetic resonance (EPR) study -- Water and saline compresses in treatment of irritant contact dermatitis: literature review -- Reaction of skin blood vessels to successive insults on normal and irritated human skin -- Specificity of retinoid-induced irritation and its role in clinical efficacy -- Topical corticosteroids in the treatment of irritant dermatitis: do they work? -- Tests for sensitive skin -- Test methods for allergic contact dermatitis in animals -- Test methods for allergic contact dermatitis in humans -- Allergic contact dermatitis: elicitation thresholds of potent allergens in humans -- Allergic contact dermatitis to topical anesthetics: a cross-sensitization phenomenon -- Contact urticaria and anaphylaxis to chlorhexidine: overview -- Immunoadjuvants in prospective testing for contact allergens -- Local lymph node assay -- Iontophresis in humans: regional variations in skin barrier function and cutaneous irritation -- Contact urticaria and contact urticaria syndrome (immediate contact reactions) -- In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials -- Photoirritation (phototoxicity) testing in humans -- Measuring and quantifying ultraviolet radiation exposures -- Determination of subclinical changes of barrier function -- Assessing validity of alternative methods for toxicity testing: role and activities of ECVAM -- Animal models of contact urticaria -- Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria -- Cosmetic reactions -- Decreasing allergic contact dermatitis frequency through dermatotoxicologic- and epidemiologic-based intervention? -- Cutaneous corticosteroid-induced glaucoma -- Pharmacogenetics and dermatology -- Ethnic differences in skin properties: objective data -- Occlusion and barrier function -- Anatomical factors affecting barrier function -- Percutaneous penetration enhancers: overview -- Percutaneous absorption of complex chemical mixtures -- Percutaneous absorption: short-term exposure, lag time, multiple exposures, model variations, and absorption from clothing -- Percutaneous absorption: 7 roles of lipids -- Chemical partitioning into powdered human stratum corneum: a useful in vitro model for studying interactions of chemicals and human skin -- Sensitive skin -- Transdermal drug delivery system: an overview -- Transdermal drug delivery system: an overview -- Iontophoresis: from historical perspective to its place in modern medicine -- Irritant dermatitis: clinical heterogeneity and contributing factors -- Systemic contact dermatitis -- Allergic contact dermatitis -- Mechanisms in irritant and allergic contact dermatitis -- Occupational allergic contact dermatitis: rational work-up -- Systemic toxicity -- Concepts in molecular dermatotoxicology -- Molecular basis of allergic contact dermatitis -- Photoirritation (phototoxicity, phototoxic dermatitis) -- Permeability of skin to metal compounds, with focus on nickel and copper -- Chemically induced scleroderma -- Chemical agents that cause depigmentation -- Carcinogenesis: current trends in skin cancer research -- Retinoids and mechanisms of their toxicity -- Mechanisms in cutaneous drug hypersensitivity reactions -- Drug-induced ocular phototoxicity -- Water: is it an irritant? -- Sodium lauryl sulfate -- Factors influencing applied amounts of topical preparations -- Barrier creams -- OECD guidelines for testing of chemicals -- Methods for in vitro percutaneous absorption -- Percutaneous absorption of hazardous substances from soil and water --
    Also available: Print – 2008
  • 2011 Springer Protocols
    edited by Jerry Zweigenbaum.
    European union regulations / Peter Furst -- China's food safety regulation and mass spectrometry / Xiaogang Chu [and others] -- United States and Japanese food regulations / Jerry Zweigenbaum -- QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods / Steven J. Lehotay -- Automated solid phase extraction / Norbert Helle, Meike Baden, and Kaj Petersen -- Multiresidue pesticide analysis by capillary gas chromatography-mass spectrometry / Jon W. Wong [and others] -- Targeted pesticide residue analysis using triple quad LC-MS/MS / Lutz Alder -- LC/TOF-MS analysis of pesticides in fruits and vegetables : the emerging role of accurate mass in the unambiguous identification of pesticides in food / Imma Ferrer, E. Michael Thurman, and Jerry Zweigenbaum -- Hormone analysis in food products / Marco H. Blokland and Saskia S. Sterk -- Analysis of multiple mycotoxins in food / Jana Hajslova, Milena Zachariasova, and Tomas Cajka -- Multi mycotoxin analysis in food products using immunoaffinity extraction / Masahiko Takino, Hiroki Tanaka, and Toshitsugu Tanaka -- Multiresidue analysis of antibiotics in food of animal origin using liquid chromatography-mass spectrometry / Katerina Mastovska -- LC-MS/MS methods for the determination of specific antibiotics residues in food matrices / Gui-Liang Chen and Yan-Yan Fang -- Identification of unknown migrants from food contact materials / Malcolm Driffield [and others] -- Halogenated persistent organic pollutants and polycyclic aromatic hydrocarbons in food / Tomas Cajka and Jana Hajslova.
  • 2006 CRCnetBASE
    Ronald Eisler
  • 2012 CRCnetBASE
    editors: Joanne M. Santini & Seamus A. Ward.
    "Arsenite contamination of drinking water is a major cause of chronic illness and mortality in many countries, but until recently little was known of the processes determining its movement and concentration. Bacterial oxidation of arsenite was first described in 1918 and thought to be a means of detoxification. It was not until 2000 that the first autotrophic arsenite-oxidising bacterium was isolated and shown to gain energy from arsenite oxidation. Since then a wide range of such bacteria has been isolated and the literature on the topic has grown rapidly. This book reviews the new understanding of the diversity and abundance of such organisms, their role in arsenic cycling in the environment and their possible relations with arsenic-dependent diseases in humans"-- Provided by publisher.
  • 2012 Wiley
    edited by Pavel Anzenbacher and Ulrich M. Zanger.
    Biochemistry and molecular genetics of drug metabolism -- Drug-metabolizing enzymes: an overview -- Cytochromes P450 -- UDP-glucuronosyltransferases -- Sulfotransferases -- Glutathione s-transferases -- Hydrolytic enzymes -- Transporting systems -- Transcriptional regulation of human drug-metabolizing cytochrome P450 enzymes -- Importance of pharmacogenomics -- Metabolism of drugs -- Introduction to drug metabolism -- Central nervous system drugs -- Cardiovascular drugs -- Anticancer drugs -- Antimicrobial agents -- Drugs against acute and chronic pain -- Drugs of abuse (including designer drugs) -- Nicotine metabolism and its implications -- Metabolism of alcohol and its consequences -- Metabolism of natural compounds -- Introduction and overview -- Food components and supplements -- Metabolism of unnatural xenobiotics -- Environmental pollutants -- Environmental estrogens -- Biotransformation of insecticides.
  • 2012 Springer
    Sandra Ceccatelli, Michael Aschner, editors.
    Annotation Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHgs accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This bookwill provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
  • 2010 Springer
    edited by Andreas Luch.
  • 2012 Springer
    edited by Andreas Luch.
    Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • 2009 Springer
    edited by Andreas Luch.
  • 2006
    P. David Josephy, Bengt Mannervik.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer Protocols
    edited by Phouthone Keohavong, Stephen G. Grant.
    Array-Based Immunoassays with Rolling-Circle Amplification Detection -- Analysis of Protein Changes Using Two-Dimensional Difference Gel Electrophoresis -- Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage -- Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System -- Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques -- Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR) -- Strategies for Measurement of Biotransformation Enzyme Gene Expression -- Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening -- TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material -- 32P-Postlabeling Analysis of DNA Adducts -- Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot -- DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry -- Analysis of DNA Strand Cleavage at Abasic Sites -- Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes Without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization Probes -- Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk -- Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair -- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice -- The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay -- Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and Mice -- Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. (Continued) -- Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model Systems -- The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic Mutation -- Molecular Analysis of Mutations in the Human HPRT Gene -- Simultaneous Quantification of t(14; 18) and HPRT Exon 2/3 Deletions in Human Lymphocytes -- Mutation Screening of the TP53 Gene by Temporal Temperature Gel Electrophoresis (TTGE) -- Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples -- ACB-PCR Quantification of Somatic Oncomutation -- Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection: Limitations and Solutions -- Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions -- Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells -- The Sister Chromatid Exchange (SCE) Assay -- The Gene Cluster Instability (GCI) Assay for Recombination -- Measuring Recombination Proficiency in Mouse Embryonic Stem Cells -- Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery -- Unscheduled DNA Synthesis: The Clinical and Functional Assay for Global Genomic DNA Nucleotide Excision Repair -- Analysis of Actively Transcribed DNA Repair Using a Transfection-Based System -- An Immunoassay for Measuring Repair of UV Photoproducts -- Analysis of Double-Strand Break Repair by Nonhomologous DNA End Joining in Cell-Free Extracts from Mammalian Cells -- Bioenergetic Analysis of Intact Mammalian Cells Using the Seahorse XF24 Extracellular Flux Analyzer and a Luciferase ATP Assay -- Quantification of Selective Phosphatidylserine Oxidation During Apoptosis -- Quantitative Method of Measuring Phosphatidylserine Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron -- Detection of Programmed Cell Death in Cells Exposed to Genotoxic Agents Using a Caspase Activation Assay.
  • 2013 Springer
    Marie-Odile Parat, editor.
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • 2012 Springer Protocols
    edited by Joshua Reineke.
    Historical overview of nanotechnology and nanotoxicology -- Characterization of nanomaterials for toxicological studies -- Methods for understanding the interaction between nanoparticles and cells -- Single-cell gel electrophoresis (comet) assay in nano-genotoxicology -- Single-cell nanotoxicity assays of superparamagnetic iron oxide nanoparticles -- Western blot analysis -- Application of reverse transcription-PCR and real-time PCR in nanotoxicity research -- Deriving TC(50) values of nanoparticles from electrochemical monitoring of lactate dehydrogenase activity indirectly -- Enzyme-linked immunosorbent assay of IL-8 production in response to silver nanoparticles -- Metabolomics techniques in nanotoxicology studies -- Nanoparticle uptake measured by flow cytometry -- Determining biological activity of nanoparticles as measured by flow cytometry -- Whole cell impedance biosensoring devices -- Free energy calculation of permeant-membrane interactions using molecular dynamics simulations -- Screening of fullerene toxicity by hemolysis assay -- Assessment of in vitro skin irritation potential of nanoparticles: RHE model -- In vivo methods of nanotoxicology -- The luminescent bacteria test to determine the acute toxicity of nanoparticle suspensions -- The primacy of physicochemical characterization of nanomaterials for reliable toxicity assessment: A review of the zebrafish nanotoxicology model -- Application of embryonic and adult zebrafish for nanotoxicity assessment -- Applications of subsurface microscopy -- Application of ICP-MS for the study of disposition and toxicity of metal-based nanomaterials -- Quantitative nanoparticle organ disposition by gel permeation chromatography -- Physiologically based pharmacokinetic modeling for nanoparticle toxicity study -- Biophysical methods for assessing plant responses to nanoparticle exposure -- In vivo nanotoxicity assays in plant models.
  • 2014 CRCnetBASE
    edited by Nancy A. Monteiro-Riviere and C. Lang Tran.
    Introduction to biomedical nanotechnology / Dorothy Farrell, George Hinkal, and Piotr Grodzinksi -- Impact of bionanointeractions of engineered nanoparticles for nanomedicine / Stefania Sabella -- Rational approach for the safe design of nanomaterials / Anna L. Costa -- Characterization of manufactured nanomaterials, dispersion, and exposure for toxicological testing / Keld A. Jensen, Giulio Pojana and Dagmar Bilanič̌ová -- Workplace inhalation exposure to engineered nanomaterials: detection, measurement, and assessment / Martie van Tongeren, Araceli Sánchez Jiménez, and Derk Brouwer -- Nanotechnology in consumer products: addressing potential health and safety implications for consumers / Treye A. Thomas -- Quantitative nanostructure-activity relationships : from unstructured data to predictive models for designing nanomaterials with controlled properties / Denis Fourches and Alexander Tropsha -- Pharmacokinetics and biodistribution of nanomaterials / Jim E. Riviere -- Advanced methodologies and techniques for assessing nanomaterial toxicity : from manufacturing to nanomedicine screening / Adriele Prina-Mello, Bashir M. Mohamed, Navin K. Verma, Namrata Jain, and Yuri Volkkov -- Detection methods for the in vivo biodistribution of iron oxide and silica nanoparticles : effects of size, surface chemistry, and shape / Heather A. Enright and Michael A. Malfatti -- Quantitative single-cell approaches to assessing nanotoxicity in nanomedicine systems / James F. Leary -- Imaging techniques for nanoparticles in skin / Tarl W. Prow -- Safety implications of nanomaterial exposure to skin / Nancy A. Monteiro-Riviere -- Interspecies comparisons of pulmonary responses to fine and/or nanoscale particulates : relevance for humans of particle-overload responses in the rat model / David B. Warheit and Kenneth L. Reed -- Current in vitro models for nanomaterial testing in pulmonary systems / Sonja Boland, Sandra Vranic, Roel Schins, and Tobias Stöger -- Nanoparticles and the immune system / Bengt Fadeel and Diana Boraschi -- Carbon nanotubes and cardiovascular disease / Peter Moøller, Cao Yi, Lise K. Vesterdal, Pernille H. Danielsen, Martin Roursgaard, Henrik Klingberg, Daniel V. Christopherson, and Steffen Loft -- Single- and multiwalled carbon nanotubes toxicity and potential applications in neuroregeneration / Fariborz Tavangarian, Guoqiang Li, and Yiyao Li -- Current in vitro models for nanomaterial testing : the reproductive system / Gary R. Hutchinson and Bryony L. Ross -- Current in vitro models or nanomaterial testing : genotoxicity issues / Laetitia Gonzalez, Sara Corradi, and Micheline Kirsch-Volders -- Cell-based targeting of anticancer nanomaterials to tumors / Matt Basel, Tej Shrestha, Hongwang Wang, and Stefan Bossmann -- Silver nanoparticles in biomedical applications / Meghan E. Samberg and Nancy A. Monteiro-Riviere -- Cytotoxicity of conjugated and unconjugated semiconductor and metal nanoparticles / Jay Nadeau -- Issues related to risk assessment of nanomaterials / Maureen R. Gwinn -- Risk assessment of engineered nanomaterials : state of the art and roadmap for future research / Danail Hristozov, Laura MacCalman, Keld A. Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes, and Antonio Marcomini.
  • 2012 Springer Protocols
    edited by Satyajit D. Sarker, Lutfun Nahar.
    An introduction to natural products isolation -- Initial and bulk extraction of natural products isolation -- Supercritical fluid extraction in natural products analyses -- Accelerated solvent extraction for natural products isolation -- Microwave-assisted extraction in natural products isolation -- An introduction to planar chromatography and its application to natural products isolation -- Isolation of natural products by low-pressure column chromatography -- Isolation of natural products by ion-exchange methods -- Separation of natural products by countercurrent chromatography -- Isolation of natural products by preparative high performance liquid chromatography (prep-HPLC) -- Isolation of natural products by preparative gas chromatography -- Hyphenated techniques and their applications in natural products analysis -- Extraction of plant secondary metabolites -- Isolation of marine natural products -- Isolation of microbial natural products -- Extraction and isolation of saponins -- Extraction and isolation of phenolic compounds -- Scaling-up of natural products isolation -- Follow-up of natural products isolation -- Natural products isolation in modern drug discovery programs.
  • 2012 ScienceDirect
    Jiří Bajgar.
    Chemical weapons -- Chemical warfare agents -- Organophosphates and nerve agents -- Toxicodynamics -- Antidotal treatment -- Prophylaxis.
  • 2015 Springer
    Daniel Thomas Ginat, Juan E. Small, Pamela Whitney Schaefer, editors.
    This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.
  • 2015 Springer
    Soodabeh Saeidnia.
    This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also℗ℓincludes discussion of℗ℓnew areas℗ℓsuch as℗ℓbiotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have℗ℓbeen the subject of discussion℗ℓin this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
  • 2012 Springer
    edited by Michael Balls, Robert D. Combes, Nirmala Bhogal.
    Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening : microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro systems / Daniel A. Casciano -- The use of integrated and intelligent testing strategies in the prediction of toxic hazard and in risk assessment / Michael Balls, Robert D. Combes, and Nirmala Bhogal.
    Also available: Print – 2012
  • Google Books
    Peter M. Eller, editor.
    Also available: Print – v. 1-2, 1984.
  • 2005
  • 2012 Springer
    Mark A. Geyer, Gerhard Gross, editors.
    This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • 2014 Springer
    Rakesh Kumar, editor.
    Preface -- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression -- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer -- RUNX2 Transcriptional Regulation in Development and Disease -- Epigenetic Mechanisms of Cancer Metastasis -- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications -- Nuclear Factors Linking Cancer and Inflammation -- Regulation of the Jak/STATs Pathways by Histone Deacetylases -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers -- Nucleolar Signaling Determines Cell Fate The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment -- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology -- Domain Specific Targeting of Cancer -- The Potential of Targeting Splicing for Cancer Therapy -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies -- Histone Demethylases in Prostate Cancer -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer -- Index.
  • 1981-
    Status: Not Checked OutLane Catalog Record
  • 2014 CRCnetBASE
    edited by Marta I. Litter [and six others].
    Section 1. Arsenic in environmental matrices (air, water, soil and biological matrices) -- section 2. Arsenic in food -- section 3. Arsenic and health -- section 4. Arsenic remediation and removal technologies -- section 5. Mitigation management and policy.
  • 2014 CRCnetBASE
    edited by Patricia B. Hoyer, The University of Arizona, College of Medicine, Tucson, USA.
    "Today, we are exposed to an ever-growing number of chemicals in the environment and there is an increasing awareness of the effects of these chemicals on the ovaries. As such, the potential for xenobiotic-induced infertility needs to be better understood. Additionally, menopause-associated disorders are of growing health concern in view of the fact that by the year 2025, 19.5% of the population of the U.S. will be menopause-aged women. Exploring research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles, this book is an essential resource for researchers in academia, regulatory agencies, and industry"--Provided by publisher.
  • 2007 CRCnetBASE
    edited by Ken Donaldson, Paul Borm.
    An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly Bérubé -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody -- Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderón-Garcidueñas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schülte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm.
  • 2012 Springer
    Klaus Aktories, Joachim H.C. Orth, Ben Adler, editors.
    Pasteurella multocida: Diseases and Pathogenesis / I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler -- Pathogenomics of Pasteurella multocida / J. D. Boyce, T. Seemann, B. Adler and M. Harper -- The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide / Marina Harper, John D. Boyce and Ben Adler -- Pasteurella multocida and Immune Cells / Katharina F. Kubatzky -- Molecular Biology of Pasteurella multocida Toxin / Joachim H. C. Orth and Klaus Aktories -- Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects / Brenda A. Wilson and Mengfei Ho -- Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin / Yasuhiko Horiguchi -- The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer / Alistair Lax.
  • 2013 Springer
    Stephen T. Sonis, Dorothy M. Keefe, editors.
  • 2015 Springer
    Gowraganahalli Jagadeesh, Pitchai Balakumar, Khin Maung-U, editors.
  • 1978-
    George D. Clayton and Florence E. Clayton, editors ; contributors, M. C. Battigelli ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1. General principles -- v. 2A, Toxicology ; v. 3. Theory and rationale of industrial hygiene practice.
  • v. 1-2, 1991-1995.
    George D. Clayton, Florence E. Clayton, editors ; contributors, R.E. Allan ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1, pt. A-B. General principles -- v. 2, pt. A-F. Toxicology.
  • 2000 Knovel
    Robert L. Harris, editor ; contributors, H.E. Ayer ... [et al.].
  • 2012 ScienceDirect
    editor, Ernest Hodgson.
    Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
  • 2005 Springer Protocols
    edited by José L. Martínez Vidal, Antonia Garrido Frenich.
  • 2015 CRCnetBASE
    edited by Heewon Lee.
  • 2014 Springer Protocols
    edited by Qing Yan, PharmTao, Santa Clara, CA, USA.
    From pharmacogenomics and systems biology to personalized care : a framework of systems and dynamical medicine / Qing Yan -- Translational bioinformatics approaches for systems and dynamical medicine / Qing Yan -- Whole blood transcriptomic analysis to identify clinical biomarkers of drug response / Grant P. Parnell and David R. Booth -- Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies / Raffaele Palmirotta [and six others] -- Approach to clinical and genetic characterization of statin-induced myopathy / QiPing Feng -- Pharmacogenomics of membrane transporters : a review of current approaches / Tristan M. Sissung [and four others] -- G protein-coupled receptor accessory proteins and signaling : pharmacogenomic insights / Miles D. Thompson [and three others] -- G protein-coupled receptor mutations and human genetic disease / Miles D. Thompson [and four others] -- Pharmacogenetics of the G protein-coupled receptors / Miles D. Thompson [and six others] -- Pharmacogenomics of heart failure / Anastasios Lymperopoulos and Faren French -- Pharmacogenomics in the development and characterization of atheroprotective drugs / Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou -- Management of side effects in the personalized medicine era : chemotherapy-induced peripheral neuropathy / Paolo Alberti and G. Cavaletti -- Pharmacogenomics of Alzheimer's disease : novel therapeutic strategies for drug development / Ramón Cacabelos [and four others] -- Pharmacogenetics of antipsychotic treatment in schizophrenia / Jennie G. Pouget and Daniel J. Müller / Pharmacogenetics of addiction therapy / David A. Nielsen [and three others] -- Pharmacogenetics in rheumatoid arthritis / Deepali Sen, Jisna R. Paul, and Prabha Ranganathan -- Pharmacogenetics of osteoporotic fractures / José A. Riancho and Flor M. Pérez-Campo -- Pharmacogenomics and pharmacoepigenomics in pediatric medicine / Barkur S. Shastry -- Pharmacogenomics in children / Michael Rieder.
  • 2013 Springer
    Luisa Rocha, Esper A. Cavalheiro, editors.
    Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
  • 2010
    Deborah Blum.
    The untold story of how poison rocked Jazz Age New York City. A pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Chief medical examiner Charles Norris and toxicologist Alexander Gettler investigate a family mysteriously stricken bald, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler create revolutionary experiments to tease out even the wiliest compounds from human tissue. From the vantage of their laboratory it also becomes clear that murderers aren't the only toxic threat--modern life has created a kind of poison playground, and danger lurks around every corner.
  • 2012 AccessMedicine
    edited by Kent R. Olson ; associate editors, Ilene B. Anderson ... [et al.] ; [by the faculty, staff, and Associates of the California Poison Control System].
    Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
  • 2007
    by the faculty, staff and associates of the California Poison Control System ; edited by Kent R. Olson ; associate editors Ilene B. Anderson ... [et. al].
    Status: Not Checked OutLane Catalog Record
  • 2008 CRCnetBASE
    edited by Steven B. Karch.
    Introduction to postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Specimen selection, collection, preservation, and security / Bradford R. Hepler and Daniel S. Isenschmid -- Common methods in postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Strategies for postmortem toxicology investigation / edited and revised by Henrik Druid -- Quality assurance in postmortem toxicology / Wilmo Andollo -- Interpretation of postmortem drug levels / Graham R. Jones.
  • 2005 CRCnetBASE
    edited by Christoph Helma.
  • 2005 WHO
    Also available: Print – 2005
  • v 1-2, 1973-75.
    Zbinden, Gerhard.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer Protocols
    edited by Mathieu Vinken, Vera Rogiers.
    Isolation and culture of mouse hepatocytes -- Cryopreservation of hepatocytes -- Culture conditions promoting proliferation and cell cycle synchronization -- Immortalized human hepatic cell lines for In vitro testing and research purposes -- Culture and functional characterization of human hepatoma hepG2s -- Establishment and characterization of an in vitro model of Fas-mediated hepatocyte cell death -- Serum-free directed differentiation of human embryonic stem cells to hepatocytes -- Human skin-derived precursor Cells: isolation, expansion, and hepatic differentiation -- Generation of hepatocytes from pluripotent stem cells for drug screening and developmental modeling -- Differentiation-promoting medium additives for hepatocyte -- Cultivation and cryopreservation -- Coculture and long-term maintenance of hepatocytes -- Primary hepatocytes in sandwich culture -- Establishing liver bioreactors for In Vitro Research -- Epigenetic modifications as antidedifferentiation strategy for primary hepatocytes in culture -- Transfection of Primary Hepatocytes with Liver-enriched transcription factors using adenoviral vectors -- Transcriptomics of hepatocytes treated with Toxicants for Investigating Molecular mechanisms underlying hepatotoxicity -- Global microRNA analysis in primary hepatocyte Cultures -- Mass Spectrometry-Based proteomics for telative protein quantification and biomarker Identification in primary human Hepatocytes -- Targeted metabolomics for homocysteine-related metabolites in primary hepatocytes -- Measurement of cytochrome P450 Enzyme Induction and Inhibition in human hepatoma cells -- Analysis of sinusoidal drug uptake transporter activities in Primary Human Hepatocytes -- Measurement of albumin secretion as functionality test in primary hepatocyte cultures -- Measurembent of Blood Coagulation Factor Synthesis in cultures of human hepatocytes -- Functionality testing of primary hepatocytes in Culture by Measuring Urea Synthesis -- Assay of Bile acid conjugation and excretion in human hepatocytes -- General cytotoxicity assessment by Means of the MTT assay -- Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures -- Critical factors in the Assessment of cholestatic liver injury In vitro -- In vitro cell culture models of hepatic steatosis -- Assessment of liver fibrotic Insults In Vitro.
  • 2013 R Soc Chem
    edited by David G. Allen and Michael D. Waters.
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • 2011 WHO
    The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
    Also available: Print – 2011
  • 2011 ScienceDirect
    edited by Ramesh Gupta.
    Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • 2012 Springer
    Nicholas J. Mantis, editor.
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • 2005 CRCnetBASE
    edited by Michael Aschner, Lucio G. Costa.
  • 2013 Springer
    Jose Russo, Irma H. Russo.
    This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • 2015 Springer Protocols
    edited by Heide Schatten, Abraham Eisenstark.
    Luminex® multiplex bead suspension arrays for the detection and serotyping of Salmonella spp / Sherry A. Dunbar [and 4 others] -- Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle / Dora Kaloyanova [and 3 others] -- Determination of antimicrobial resistance in Salmonella spp / Belgode N. Harish and Godfred A. Menezes -- Red-mediated recombineering of Salmonella enterica genomes / Frederik Czarniak and Michael Hensel -- A method to introduce an internal tag sequence into a Salmonella chromosomal gene / Weidong Zhao and Stéphane Méresse -- Generation and use of site-directed chromosomal cyaA' translational fusions in Salmonella enterica / Francisco Ramos-Morales [and 3 others] -- Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot / Edith Porter [and 3 others] -- Detecting non-typhoid Salmonella in humans by enzyme-linked immunosorbent assays (ELISAs) : practical and epidemiological aspects / Katrin G. Kuhn [and 3 others] -- Study of the Stn protein in Salmonella; a regulator of membrane composition and integrity / Masayuki Nakano [and 4 others] -- Development of a bacterial nanoparticle vaccine / Carlos Gamazo [and 4 others] -- Direct attachment of nanparticle cargo to Salmonella typhimurium membranes designed for combination bacteriotherapy against tumors / Robert Kazmierczak [and 3 others] -- Applications of microscopy in Salmonella research / Layla M. Malt [and 3 others] -- Live cell imaging of intracellular Salmonella enterica / Alexander Kehl and Michael Hensel -- In vitro modeling of gallbladder-associated Salmonella spp. colonization / Geoffrey Gonzalez-Escobedo and John S. Gunn -- Salmonella phages and prophages : genomics, taxonomy, and applied aspects / Andrea I. Moreno Switt [and 6 others].
  • 2007 Springer Protocols
    edited by Heide Schatten and Abraham Eisenstark.
    Quantitative, multiplexed detection of salmonella and other pathogens by Luminex xMAP suspension array / Sherry A. Dunbar and James W. Jacobson -- Detection of salmonella by bacteriophage felix 01 / Jonathan C. Kuhn -- Physical mapping of salmonella genomes / Shu-Lin Liu -- Cloth-based hybridization array system for the identification of antibiotic resistance genes in salmonella / Burton W. Blais and Martine Gauthier -- Genome-based identification and molecular analysee of pathogenicity islands and genomic islands in Salmonella enterica / Michael Hensel -- Determination of the gene content of salmonella genomes by microarray analysis / Steffen Porwollik and Michael McClelland -- In vivo excision, cloning, and broad-host-range transfer of large bacterial DNA segments using VEX-capture / James W. Wilson and Cheryl A. Nickerson -- Amplified fragment length polymorphism analysis of Salmonella enterica / Ruiting Lan and Peter R. Reeves -- Salmonella phages and prophages : genomics and practical aspects / Andrew M. Kropinski ... [et al.] -- Salmonella typhimurium phage typing for pathogens / Wolfgang Rabsch -- Salmonella phages examined in the electron microscope / Hans-W. Ackermann -- Applications of cell imaging in salmonella research / Charlotte A. Perrett and Mark A. Jepson -- Analysis of kinesin accumulation on salmonella-containing vacuoles / Audrey Dumont ... [et al.] -- Magnesium, manganese, and divalent cation transport assays in intact cells / Michael E. Maguire -- Methods in cell-to-cell signaling in salmonella / Brian M. M. Ahmer ... [et al.] -- Development of salmonella strains as cancer therapy agents and testing in tumor cell lines / Abraham Eisenstark ... [et al.] -- Further resources for molecular protocols in salmonella research / Abraham Eisenstark and Kelly K. Edwards.
  • 2012 Wiley
    Richard J. Lewis, Sr.
    "Includes comprehensive hazard information on the substances encountered in the workplace. The objective of the work is to promote safety by providing the most up-to-date hazard information available"--Provided by publisher. "Since its inception in the early 1950's, this book has become the "bible" for those who need to evaluate the hazard of substances used in commerce. The book contains extensive data on approximately 28,000 substances. It is designed to fill the information needs of professionals who must work with and evaluate the hazards of chemicals"--Provided by publisher.
  • 2010 WHO
    first draft prepared by Mr. Philip Copestake.
    Also available: Print – 2010
  • 2013 Springer
    Mario A. Dicato, editor.
    Drug Interactions and Pharmacogenetics -- Breast Cancer -- Lung Cancer -- Gastrointestinal Cancer: Selection of Clinically Relevant Drug-Induced Toxicities Encountered in Gastrointestinal Cancer Treatment -- Gynecologic Cancer -- Genitourinary Cancer -- Central Nervous System -- Bone Marrow Toxicity: Red Blood Cells -- Bone Marrow Toxicity: White Blood Cells -- Dermatologic Side Effects of Systemic Anticancer Therapy -- Myeloid Malignancies -- Lymphoma -- Multiple Myeloma -- Preservation of Fertility in the Cancer Patient -- Cardiotoxicity -- Toxicity of Bone-Targeted Agents in Malignancy -- State of the Art of Antiemetic Therapy -- Side Effects of Nociceptive Cancer Pain Treatments in Adults -- Totally Implanted Access Ports: Indications and Prevention of Complications.
  • 2002 Knovel
    Richard P. Pohanish, editor.
  • 2008 WHO
    Also available: Print – 2008
  • 2007 IARC
    Also available: Print – 2007
  • 2002 IARC
    Also available: Print – 2002
  • 2013 Springer
    Erich Gulbins, Irina Petrache, editors.
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • 2013 Springer
    Erich Gulbins, Irina Petrache, editors.
    Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • 2010 WHO
    first draft prepared by Peter Watts and Paul Howe.
    Also available: Print – 2010
  • 2012 Springer Protocols
    edited by Leslie W. Tari.
    The utility of structural biology in drug discovery / Leslie W. Tari -- Genetic construct design and recombinant protein expression for structural biology / Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson -- Purification of proteins for crystallographic applications / Daniel C. Bensen -- Protein crystallization for structure-based drug design / Isaac D. Hoffman -- X-ray sources and high-throughput data collection methods / Gyorgy Snell -- The use of molecular graphics in structure-based drug design / Paul Emsley and Judit É. Debreczeni -- Crystallographic fragment screening / John Badger -- The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase / Mark L. Cunningham -- Leveraging structural information for the discovery of new drugs : computational methods / Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone -- Chemical informatics : using molecular shape descriptors in structure-based drug design / Andy Jennings -- Accounting for solvent in structure-based drug design / Leslie W. Tari -- Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein / Andrew D. Ferguson -- Application of SBDD to the discovery of new antibacterial drugs / John Finn -- Leveraging SBDD in protein therapeutic development : antibody engineering / Gary L. Gilliland [and others] -- A medicinal chemistry perspective on structure-based drug design and development / Shawn P. Maddaford.
  • 2013 Springer
    Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan.
    Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • 2005 CRCnetBASE
    Christopher J. Gordon.
  • 2013 Springer Protocols
    edited by Paul C. Barrow.
    ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.
  • 2013 CRCnetBASE
    edited by Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, and Chirukandath Gopinath.
    Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2004 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2004
  • 2004 ATSDR
    prepared by Syracuse Research Corporation under contract No. 205-1999-00024 ; prepared for U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2004
  • 2007 ATSDR
    prepared by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2004 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2004
  • 2004 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2004
  • 2006 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2006
  • 2006 ATSDR
    prepared by Syracuse Research Corporation under Contract No. 200-2004-09793; prepared for U.S. Deptartment of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2006
  • 2010 ATSDR
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2006 ATSDR
    prepared by Syracuse Research Corporation under contract No. 200-2004-09793 ; prepared for U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2006
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2006 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2006
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2006 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793; prepared for U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2006
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2005 ATSDR
    prepared by Syracuse Research Corporation under contract no. 205-1999-00024 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2005
  • 2008 CRCnetBASE
    Elsa Nielsen, Grete stergaard, John Christian Larsen.
    International and federal bodies involved in risk assessment of chemical substances -- Data for hazard assessment -- Hazard assessment -- Standard setting : threshold effects -- Standard setting : non-threshold effects (carcinogenicity) -- Exposure assessment -- Risk characterization -- Regulatory standards set by various bodies -- Combined actions of chemicals in mixture.
  • v. <1>, <1978>
    Irving Sunshine, section editor.
    Status: Not Checked OutLane Catalog Record
  • 2005 CRCnetBASE
    edited by Shih-Houng Young and Vincent Castranova.
  • 2012 Knovel
    [edited by] Ken Donaldson... [et al.].
    "The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors"-- Provided by publisher.
  • 2007 CRCnetBASE
    edited by Yogesh C. Awasthi.
  • 2006 ScienceDirect
    edited by Ramesh C. Gupta.
  • 2007 CRCnetBASE
    edited by Shayne C. Gad.
    Introduction: the gastrointestinal (GI) tract as a barrier and as an absorptive and metabolic organ / Shayne C. Gad -- Methods for the analysis of gastrointestinal function / Robin C. Guy -- Safety pharmacology and the GI tract / Henry I. Jacoby -- Gastronintestinal tract development and its importance in toxicology / Joseph V. Rodricks, Allison A. Yates, and Claire L. Kruger -- The GI tract as major route of pharmaceutical administration / Robert W. Kapp, Jr. -- Gastrointestinal function and toxicology in canines / Charles Spainhour -- Absorption of macromolecules by mammalian intestinal epithelium / Shayne C. Gad -- Peyer's patch epithelium: an imperfect barrier / Gary R. Burleson and Florence G. Burleson -- Alteration of intestinal function by xenobiotic exposure: animal models / Shayne C. Gad -- Intestinal absorption and metabolism of xenobiotics in laboratory animals / William J. Brock -- Normal and abnormal intestinal absorption by humans / David W. Hobson and Valerie L. Hobson -- Intestinal absorption and metabolism of xenobiotics in humans / William J. Brock and David W. Hobson.
  • 2005 CRCnetBASE
    edited by Joan B. Tarloff, Lawrence H. Lash.
  • 2006 CRCnetBASE
    edited by Donald E. Gardner.
  • 2005 CRCnetBASE
    edited by Parviz M. Pour.
  • 2010 CRCnetBASE
    edited by Nancy A. Monteiro-Riviere.
    Pt. 1. Skin morphology and barrier properties -- pt. 2. Altered barriers -- pt. 3. Methods of delivery -- pt. 4. Skin toxicity.
  • v.1-2=, 2014 CRCnetBASE
    v.2 (2014) CRCnetBASE
    editor, Gian Paolo Rossini.
    Structured account of the existing knowledge of toxic algae, the chemistry of the toxins they produce, the effects these substances exert in humans and wildlife, as well as the strategies envisaged to protect public health and the environment. Covers recent advances in the understanding of the biology of toxin producers and the factors involved in the appearance and dynamics of harmful algae blooms, the factors affecting toxin production, the synthesis of toxins both in natural producers and by chemical means in a lab, and the toxin groups posing continuing and novel. Studies effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities.
  • 2010 Springer
    R. Manjunatha Kini, Kenneth J. Clemetso, Francis S. Markland, Mary Ann McLane, Takashi Morita, editors.
    "Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents."
  • 2005 CRCnetBASE
    edited by Waldemar M. Dabrowski, Zdzislaw E. Sikorski.
  • 2007 CRCnetBASE
    edited by Keith A. Foster, Peter Hambleton, Clifford C. Shone.
  • 2011 ScienceDirect
    Scott A. Weinstein, David A. Warrell, Julian White and Daniel E. Keyler.
    This book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity. Fills a gap in the toxinological, medical and herpetological literature by providing a comprehensive review of this entire assemblage of snakes, with particular attention given to their capacity, real or rumored, to cause harm to humans A patient-centered, evidence-based approach is applied to analyzing documented case reports of bites inflicted by approximately 100 species. Clinical management of medically significant bites from non-front-fanged colubroids is methodically reviewed, and specific recommendations are provided.
  • 2015
    European Monitoring Centre for Drugs and Drug Addiction.
    Wastewater analysis is a rapidly developing scientific discipline with the potential for monitoring real-time population-level trends in illicit drug use. Originally used in the 1990s to monitor the environmental impact of liquid household waste, the method has since been used to estimate illicit drug consumption in different cities (Daughton, 2001; Zuccato et al., 2008; van Nuijs et al., 2011). It involves sampling a source of wastewater, such as a sewage influent to a wastewater treatment plant. This allows scientists to estimate the quantity of drugs consumed in a community by measuring the levels of illicit drugs and their metabolites excreted in urine (Zuccato et al., 2008).
  • 2010 WHO
    World Health Organization.
    "The purpose of this publication is to provide its users with guidance to identify, acquire and use the information needed to assess chemical hazards, exposures and the corresponding health risks in their given health risk assessment contexts at local and/or national levels. The toolkit provides information for conducting a human health risk assessment, identifies information that must be gathered to complete an assessment and provides electronic links to international resources from which the user can obtain information and methods essential for conducting the human health risk assessment"--Publisher's description.
    Also available: Print – 2010
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