Lane Medical Library

Books by Subject

all 171 titles

Toxicology

  • Digital
    Chang-Hwei Chen.
    Springer2012
  • Digital
    edited by Grant N. Pierce, Volodymyr I. Mizin and Alexander Omelchenko.
    Springer2013
    "The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.
  • Digital
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Springer2013
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Digital
    edited by Nikhil C. Munshi, Kenneth C. Anderson.
    Springer2013
    Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Digital
    edited by Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova.
    ScienceDirect2012
    A. Engineered nanomaterials: hazard, exposure and safety assessment. Interactions with the human body / Renato Colognato ... [et al.] -- Exposure assessment / Antonio Bergamaschi, Ivo Iavicoli and Kai Savolainen -- Biomonitoring / Enrico bergamaschi and Andrea Magrini -- Critical evaluation of toxicity tests / Maria Dusinska ... [et al.] -- Computational approaches / Vidana Epa, Dave Winkler and Lang Tran -- Regulation and legislation / Maureen R. Gwinn and Birgit Sokull-Klüttgen -- B. Engineered nanomaterials: impact on human health. Respiratory system / Ken Donaldson and Craig Poland -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills and Rodger Duffin -- Neurological system / Sandra Ceccatelli and Giuseppe Bardi -- Immune system / Diana Boraschi and Albert Duschl -- Skin / Nancy A. Monteiro-Riviere and Francesca Larese Filon -- Gastrointestinal tract / Mark A. Jepson -- Reproductive toxicity / Karin Sørig Hougaard and Luisa Campagnolo -- Genotocicity and cancer / Shareen H. Doak, Ying Liu and Chunying Chen -- C. Biomedical applications of engineered nanomaterials. Diagnostic applications / Kalcheng and Zhen Cheng -- Therapeutic applications / Cyrill Bussy ... [et al.] -- Annex: synthesis of engineered nanomaterials / Muhammet S. toprak, Gulaim A. Seisenbaeva and Vadim G. Kessler.
  • Digital
    edited by Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova.
    ScienceDirect2017
    Bio-nano interactions / Dana Westmeier, Shirley K. Knauer, Roland H. Stauber, Dominic Docter -- Physicochemical characterization / Kristen Rasmussen, Hubert Rauscher, Agnieszka Mech -- Toxicity tests / Maria Dusinska, Elise Rundén-Pran, Jürgen Schnekenburger, Jun Kanno -- Computational approaches / Tu C. Le, Vidana Epa, Lang Tran, Dave Winkler -- Exposure Assessment / Kai Savolainen, Antonio Pietroiusti -- Biomonitoring / Enrico Bergamaschi, Irirna Guseva Canu, Adriele Prina-Mello, Regulation and legislation / Kirsten Rasmussen, Brigit Sokull-Klüttgen, IL Je Yu, Jun Kanno, Akihiro Hirose, Maureen R. Gwinn -- Risk assessment and risk management / Robert Landsiedel, Ursula G. Sauer, Wim H De Jong -- Respiratory system, part one / Craig A. Plooand, Ken Donaldson -- Respiratory system, part two / Harri Alenius, Michael R. Shurin, Galina V. Shurin, Don Beezhold, Anna A. Shvedova -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills, Rodger Duffin -- Neurological system / Myrtill Simkó, Mats-olof Mattsson, Robert A. Yokel -- Immune system / Diana Boraschi, Bengt Fadeel, Albert Duschl -- Endorine system / Xuefei Lu, Yong Zhu, Tao Zhu -- Skin / Nancy A. Monteiro-Riviere, Francesca Larese Filon -- Gastrointestinal system / Mark A. Jepson, Hans Bouwmeester -- Reproduction and development / Luisa Campagnolo, Karin S. Hougard -- Genotoxicitiy and cancer / Shareen H. Doak, Ying Liu, Chunying Chen.
  • Digital/Print
    IOMC, Inter-Organization Programme for the Sound Management of Chemicals.
    Digital : WHO2013
    Print2013
  • Print
    editors: Cheryl J. Cherpitel [and others].
    Status: Not Checked OutLane Catalog Record
  • Digital
    NLM2016
  • Digital/Print
    Chris Peers, Prem Kumar, Christopher Wyatt, Estelle Gauda, Colin A. Nurse, Nanduri Prabhakar, editors.
    Digital : Springer2015
    Print2015
    Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
  • Digital
    Andrea B. Weir, Margaret Collins, editors.
    Springer2013
    Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
  • Digital
    Chirukandath Gopinath, Vasanthi Mowat.
    Springer2014
    "This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years."--Publisher's website.
  • Digital
    Mahdi Balali-Mood, Mohammad Abdollahi, editors.
    Springer2014
    This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.
  • Digital
    edited by Suresh C. Sikka, Wayne J.G. Hellstrom.
    ScienceDirect2017
    Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men's reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health.
  • Digital
    ANSI2003Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-3
  • Digital
    edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush.
    ScienceDirect2017
    Biometals and Alzheimer's disease / Alexandra I. Mot, Peter J. Crouch -- Copper in Alzheimer's disease / Rosanna Squitti, Maricarla Ventriglia, Mariacristina Siotto, Carlo Salustri -- The role of selenium in neurodegenerative diseases / Bárbara R. Cardoso, Dominic J. Hare, Ashley I. Bush -- Does HFE genotype impact macrophage phenotype in disease process and therapeutic response? / Anne M. Nixon, James R. Connor -- Chemical elements and oxidative status in neuroinflammation / Michela Ferraldeschi, Silvia Romano, Maria C. Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria A. Stazi, Alessandro Alimonti, Marco Salvetti, Giovanni Ristori -- Metals and neuroinflammation / Stephen C. Bondy -- Metals and prions / David R. Brown -- Manganese and neurodegeneration / Dinamene Marques Dos Santos, Michael Aschner, Ana P. Marrielha Dos Santos -- Zinc in autism / Stefanie Grabrucker, Andreas M. Grabrucker -- Metals and motor neuron disease / Per M. Roos -- Metals and Lysosomal storage disorders / Henna Kontinnen, Katarína Lejavová, Tarja Malm, Katja M Kanninen -- Developmental exposure to metals and its contribution to age-related neurodegeneration / Lucio G. Costa -- Metal biology associated with Huntington's disease / Terry Jo V. Bichell, Timothy C. Halbesma, K. Grace Tipps, Aaron B. Bowman -- Metal-binding to Amyloid-ss peptide / Melisa Del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller -- Metals and mitochondria in neurodegeneration / Germán Plascencia-Villa, Miguel José- Yacamán, George Perry -- Metal transporters in neurodegeneration / Hong Jiang -- Metal imaging in the brain / David C. Dorman -- Metalloregulation of protein clearance / Alejandra Ramírez Muñoz, Mark A. Greenough, Ashley I. Bush, Carlos M. Opazo -- Metals and autophagy in neurotoxicitiy / Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo -- An overview of multifunctonal metal chelators as potential treatments for neurodegenerative diseases / Frank W. Lewis, David Tétard -- Abnormal function of metalloprotein underlies most neurodegenerative diseases / Katja M. Kanninen, Anthony R. White.
  • Digital
    Joseph Jankovic, chief editor ; Alberto Albanese [and others].
    ClinicalKey2009
    The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat, such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you'll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.
  • Digital
    Aamir Ahmad, editor.
    Springer2013
    This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed -- source other than Library of Congress.
  • Digital
    Tyler J. Curiel, editor.
    Springer2013
    This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • Digital
    Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors.
    Springer2014
    This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Digital/Print
    Digital : IARC2010
    Print2010
    Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
  • Print
    editor, Curtis D. Klaassen.
    Status: Not Checked OutLane Catalog Record
    Unit I: General principles of toxicology -- History and scope of toxicology / Michael A. Gallo -- Principles of toxicology / David L. Eaton and Steven G. Gilbert -- Mechanisms of toxicity / Zoltán Gregus -- Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Unit II: Disposition of toxicants -- Absorption, Distribution, and excretion of toxicants / Lois D. Lehman-McKeeman -- Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie -- Toxicokinetics / Danny D. Shen -- Unit III: Non-organ-directed toxicity -- Chemical carcinogens / James E. Klaunig and Lisa M. Kamendulis -- Genetic toxicology / R. Julian Preston and George R. Hoffmann -- Developmental toxicology / John M. Rogers and Robert J. Kavlock -- Unit IV: Target organ toxicity -- Toxic responses of the blood / John C. Bloom and John T. Brandt -- Toxic responses of the immune system / Norbert E. Kaminski ... [et al.] -- Toxic responses of the liver / Hartmut Jaeschke -- Toxic responses of the kidney / Rick G. Schnellmann -- Toxic responses of the respiratory system / Hanspeter R. Witschi ... [et al.] -- Toxic responses of the nervous system / Virginia C. Moser ... [et al.] -- Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes -- Toxic responses of the heart and vascular system / Y. James Kang -- Toxic responses of the skin / Robert H. Rice and Theodora M. Mauro -- Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray Jr. -- Toxic responses of the endocrine system / Charles C. Capen -- Unit V: Toxic agents -- Toxic effects of pesticides / Lucio G. Costa -- Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes -- Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand, and D. Alan Warren -- Health effects of radiation and radioactive materials / Naomi H. Harley -- Properties and toxicities of animal venoms / John B. Watkins, III -- Toxic effects of plants / Stata Norton -- Unit VI: Environmental toxicology -- Air pollution / Daniel L. Costa -- Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Unit VII: Applications of toxicology -- Food toxicology / Frank N. Kotsonis and George A. Burdock -- Analytic/forensic toxicology / Alphonse Poklis -- Clinical toxicology / Louis R. Cantilena Jr. -- Occupational toxicology / Peter S. Thorne.
  • Digital
    editor, Curtis D. Klaassen.
    McGraw-Hill eBook Library2013
    Unit I:General Principles of Toxicology -- CHAPTER 1: History and Scope of Toxicology -- CHAPTER 2: Principles of Toxicology -- CHAPTER 3: Mechanisms of Toxicity -- CHAPTER 4: Risk Assessment --Unit II:Disposition of Toxicants -- CHAPTER 5: Absorption, Distribution, and Excretion of Toxicants -- CHAPTER 6: Biotransformation of Xenobiotics -- CHAPTER 7: Toxicokinetics --Unit III:Non-Organ-Directed Toxicity -- CHAPTER 8: Chemical Carcinogenesis -- CHAPTER 9: Genetic Toxicology -- CHAPTER 10: Developmental Toxicology --Unit IV:Target Organ Toxicity -- CHAPTER 11: Toxic Responses of the Blood -- CHAPTER 12: Toxic Responses of the Immune System -- CHAPTER 13: Toxic Responses of the Liver -- CHAPTER 14: Toxic Responses of the Kidney -- CHAPTER 15: Toxic Responses of the Respiratory System -- CHAPTER 16: Toxic Responses of the Nervous System -- CHAPTER 17: Toxic Responses of the Ocular and Visual System -- CHAPTER 18: Toxic Responses of the Heart and Vascular System -- CHAPTER 19: Toxic Responses of the Skin -- CHAPTER 20: Toxic Responses of the Reproductive System -- CHAPTER 21: Toxic Responses of the Endocrine System --Unit V:Toxic Agents -- CHAPTER 22: Toxic Effects of Pesticides -- CHAPTER 23: Toxic Effects of Metals -- CHAPTER 24: Toxic Effects of Solvents and Vapors -- CHAPTER 25: Toxic Effects of Radiation and Radioactive Materials -- CHAPTER 26: Toxic Effects of Plants and Animals -- CHAPTER 27: Toxic Effects of Calories --Unit VI:Environmental Toxicology -- CHAPTER 28: Nanotoxicology -- CHAPTER 29: Air Pollution --Unit VII:Applications of Toxicology -- CHAPTER 30: Ecotoxicology -- CHAPTER 31: Food Toxicology -- CHAPTER 32: Analytical and Forensic Toxicology -- CHAPTER 33: Clinical Toxicology -- CHAPTER 34: Occupational Toxicology -- CHAPTER 35: Regulatory Toxicology.
  • Digital
    Trevor M. Penning, Editor.
    Springer2011
    Historical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
  • Print
    William J. Rea.
    Status: Not Checked OutLane Catalog Record
    v. 3. Clinical manifestations of pollutant overload -- v. 4. Tools of diagnosis and methods of treatment.
  • Digital
    Keya Chaudhuri, S.N. Chatterjee.
    Springer2009
  • Digital/Print
    Digital : WHO2014
    Print2014
  • Digital
    [edited by] Michael R. Dobbs.
    ClinicalKey2009
    Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors, such as heavy metals and pesticides, and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection.
  • Digital
    edited by Christer Hogstrand and Peter Kille.
    ScienceDirect2008
  • Digital
    edited by Bruce A. Fowler.
    ScienceDirect2013
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
  • Digital
    edited by Brad Reisfeld, Arthur N. Mayeno.
    Springer Protocolsv.1 (2012)
    Springer Protocolsv.2 (2012)
    V. 1. What is computational toxicology? / Brad Reisfeld and Arthur N. Mayeno. Computational toxicology : application in environmental chemicals / Yu-Mei Tan [and others] Role of computational methods in pharmaceutical sciences / Sandhya Kortagere, Markus Lill, and John Kerrigan. Best practices in mathematical modeling / Lisette G. de Pillis and Ami E. Radunskaya. Tools and techniques / Arthur N. Mayeno and Brad Reisfeld. Prediction of physicochemical properties / John C. Dearden. Informing mechanistic toxicology with computational molecular models / Michael R. Goldsmith [and others] Chemical structure representations and applications in computational toxicity / Muthukumarasamy Karthikeyan and Renu Vyas. Accessing and using chemical property databases / Janna Hastings, Zara Josephs, and Christoph Steinbeck. Accessing, using, and creating chemical property databases for computational toxicology modeling / Antony J. Williams [and others] Molecular dynamics / Xiaolin Cheng and Ivaylo Ivanov. Introduction to pharmacokinetics in clinical toxicology / Pavan Vajjah, Geoffrey K. Isbister, and Stephen B. Duffull. Modeling of absorption / Walter S. Woltosz, Michael B. Bolger, and Viera Lukacova. Prediction of pharmacokinetic parameters / A.K. Madan and Harish Dureja. Ligand- and structure-based pregnane X receptor models / Sandhya Kortagere, Matthew D. Krasowski, and Sean Ekins. Non-compartmental analysis / Johan Gabrielsson and Daniel Weiner. Compartmental modeling in the analysis of biological systems / James B. Bassingthwaighte [and others] Physiologically based pharmacokinetic/toxicokinetic modeling / Jerry L. Campbell [and others] Interspecies extrapolation / Elaina M. Kenyon. Population effects and variability / Jean Lou Dorne [and others] Mechanism-based pharmacodynamic modeling / Melanie A. Felmlee, Marilyn E. Morris, and Donald E. Mager -- v. 2. Methods for building QSARs / James Devillers. Accessing and using chemical databases / Nikolai Nikolov [and others] From QSAR to QSIIR : searching for enhanced computational toxicology models / Hao Zhu. Mutagenicity, carcinogenicity, and other end points / Romualdo Benigni [and others] Classification models for safe drug molecules / A.K. Madan, Sanjay Bajaj, and Harish Dureja. QSAR and metabolic assessment tools in the assessment of genotoxicity / Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova. Gene expression networks / Reuben Thomas and Christopher J. Portier. Construction of cell type-specific logic models of signaling networks using CellNOpt / Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez. Regulatory networks / Gilles Bernot, Jean-Paul Comet, and Christine Risso-de Faverney. Computational reconstruction of metabolic networks from KEGG / Tingting Zhou. Biomarkers / Harmony Larson [and others] Biomonitoring-based environmental public health indicators / Andrey I. Egorov, Dafina Dalbokova, and Michal Krzyzanowski. Modeling for regulatory purposes (risk and safety assessment) / Hisham El-Masri. Developmental toxicity prediction / Raghuraman Venkatapathy and Nina Ching Y. Wang. Predictive computational toxicology to support drug safety assessment / Luis G. Valerio Jr. Developing a practical toxicogenomics data analysis system utilizing open-source software / Takehiro Hirai and Naoki Kiyosawa. Systems toxicology from genes to organs / John Jack, John Wambaugh, and Imran Shah. Agent-based models of cellular systems / Nicola Cannata [and others] Linear algebra / Kenneth Kuttler. Ordinary differential equations / Jiří Lebl. On the development and validation of QSAR models / Paola Gramatica. Principal components analysis / Detlef Groth [and others] Partial least squares methods : partial least squares correlation and partial least square regression / Hervé Abdi and Lynne J. Williams. Maximum likelihood / Shuying Yang and Daniela De Angelis. Bayesian inference / Frederic Y. Bois.
  • Digital
    edited by C. Dishovsky and A. Pivovarov.
    Springer2009
  • Digital
    Maines, Mahin D.
  • Digital
    Archer, Trevor K.; Kostrzewa, Richard M.
    Consists of volumes that cover the latest developments in neurotoxicity studies including neurodegeneration, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.
  • Digital/Print
    Digital : WHO2011
    Print2011
    Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
  • Digital/Print
    Digital : WHO2014
    Print2014
  • Digital
    edited by Mariapia Viola Magni.
    Springer2010
    Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • Digital
    edited by Craig Harris, Jason M. Hansen.
    Springer Protocols2012
    In vivo models of developmental toxicology / Jason M. Hansen -- Caenorhabditis elegans as a model in developmental toxicology / Windy A. Boyd, Marjolein V. Smith, and Jonathan H. Freedman -- Zebrafish embryo developmental toxicology assay / Julieta M. Panzica-Kelly, Cindy X. Zhang, and Karen Augustine-Rauch -- Gene knockdown by morpholino-modified oligonucleotides in the Zebrafish (Danio rerio) model : applications for developmental toxicology / Alicia R. Timme-Laragy, Sibel I. Karchner, and Mark E. Hahn -- Amphibian model for studies of developmental reproductive toxicity / Cecilia Berg -- Avian models in teratology and developmental toxicology / Susan M. Smith, George R. Flentke, and Ana Garic -- Overview of in vitro models in developmental toxicology / Craig Harris -- Primary cell and micromass culture in assessing developmental toxicity / M. Pratten -- Embryonic stem cell test : stem cell use in predicting developmental cardiotoxicity and osteotoxicity / Beatrice Kuske, Polina Y. Pulyanina, and Nicole I. zur Nieden -- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay / Marianne Barrier [and others] -- Murine limb bud in culture as an in vitro teratogenicity test System / France-Helene Paradis, Chunwei Huang, and Barbara F. Hales -- Rodent whole embryo culture / Craig Harris -- Rabbit whole embryo culture / Valerie A. Marshall and Edward W. Carney -- Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example / Helen J. Renaud, Allison Rutter, and Louise M. Winn -- Methodological approaches to cytochrome P450 profiling in embryos / Jared V. Goldstone and John J. Stegeman -- Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos / Shao-yu Chen -- Regulation and control of AP-1 binding activity in embryotoxicity / Terence R.S. Ozolins -- Thioredoxin redox status assessment during embryonic development : the redox western / Jason M. Hansen -- Methods for the determination of plasma or tissue glutathione levels / Trent E. Tipple and Lynette K. Rogers -- Oxidative stress, thiols, and redox profiles / Craig Harris and Jason M. Hansen -- Review of toxicogenomic approaches in developmental toxicology / Joshua F. Robinson, Jeroen L.A. Pennings, and Aldert H. Piersma -- Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events / Elena Menegola, Graziella Cappelletti, and Francesca Di Renzo -- DNA methylation screening and analysis / Karilyn E. Sant, Muna S. Nahar, and Dana C. Dolinoy -- Assessment of histiotrophic nutrition using fluorescent probes / Jeffrey Ambroso and Craig Harris -- Diabetic embryopathy / Ulf J. Eriksson and Parri Wentzel -- Gene expression analysis in developing embryos : in situ hybridization / Siew-Ging Gong -- Assessment of gross fetal malformations : the modernized wilson technique and skeletal staining / Robert E. Seegmiller [and others].
  • Digital
    edited by Arnold Schecter.
    Wiley2012
    Persistent organic pollutants : an overview / Daniele Wikoff, Lauren Fitzgerald, Linda Birnbaum Toxic equivalency factors (TEFS) for dioxin and related compounds / Michael DeVito Historic and newer persistent organic pollutants (POPS) in U.S. food / Janice Huwe -- Flame retardants : PBDES and their replacements / Thomas Webster, Heather Stapleton -- Pharmacokinetics of TCDD and related compounds / James Olson -- Immunomodulation by persistent organic pollutants / Robert Luebke [and others] -- Developmental neurotoxicity of dioxins / G. Jean Harry, Pamela J. Lein -- Epidemiological evidence on the health effects of perfluorooctanoic acid (PFOA) / Kyle Steenland, Tony Fletcher, David Savitz -- Polybrominated dibenzo-p-dioxins and dibenzofurans / Kurunthachalam Kannan, Chunyang Liao, Hyo-Bang Moon -- Epidemiological studies on cancer and exposure to dioxin and related compounds / Lennart Hardell, Mikeal Eriksson -- Reproductive and developmental epidemiology of dioxins -- Anne Sweeney [and others] -- Bisphenol A / Thaddeus Shug [and others] -- Phthalates : human exposure and related health effects / John D. Meeker, Kelly K. Ferguson -- The seveso accident / Angela Cecilia Pesatori, Pier Alberto Bertazzi -- Agent orange : long term health and environmental impact in Vietnam / Susan Hammond, Arnold Schecter -- The yusho and yucheng rice oil poisoning incidents / Yoshito Masuda, Arnold Schecter -- The Binghamtom New York electrical transformer fire incident of 1981 / Nancy Kim, Arnold Schecter -- The Yushchenko dioxin poisoning : chronology and pharmacokinetics / John Jake Ryan -- Human health risk assessment of POPS / David Szabo, Anne E. Loccisano.
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation Under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2010
    Print2010
  • Digital/Print
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2009
    Print2009
  • Digital
    edited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy.
    Wiley2016
    As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. - Guides researchers as to what drug safety experiments are both practical and useful- Covers a variety of key topics - safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and -omics tools- Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods- Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
  • Digital
    edited by Neil Kaplowitz and Laurie Deleve.
    ScienceDirect2013
    I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
  • Print
    Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Jean-Charles Gautier.
    Springer Protocols2009
    Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
  • Digital
    edited by Amanda J. Jenkins ; foreword by Yale H. Caplan.
    Springer2008
  • Digital
    Hans-Werner Vohr (ed.).
    Springer2005
  • Digital
    Roger G. Pertwee, editor.
    Springer2015
    There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced ℓ́ℓautoprotectionℓ́ℓ, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose endocannabinoid-induced autoimpairment. This volume describes the physiology, pathophysiology and pharmacology of the endocannabinoid system and potential strategies for targeting this system in the clinic.
  • Digital
    Mary E. Abood, Roger G. Sorensen, Nephi Stella, editors.
    Springer2013
    Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • Digital
    Sushil K. Khetan.
    Wiley2014
    Environmental endocrine disruptors -- Part I. Mechanisms of hormonal action and putative endocrine disruptors. Mechanisms of endocrine system function -- Environmental chemicals targeting estrogen signaling pathways -- Anti-androgenic chemicals -- Thyroid-disrupting chemicals -- Activators of PPAR, RXR, AhR, and steriodogenic factor 1 -- Effects of EDC mixtures -- Environmentally induced epigenetic modifications and transgenerational effects -- -- Part II. Removal mechanisms of EDCs through biotic and abiotic processes. Biodegradations and biotransformations of selected examples of EDCs -- Abiotic degradations / transformations of EDCs through oxidation processes -- -- Part III. Screening and testiing for potential EDCs, implications for water quality sustainability, policy and regulatory issues, and green chemistry principles in the design of safe chemicals and remediation of EDCs. Screening and testing programs for EDCs -- Trace contaminants : implications for water quality sustainability -- Policy and regulatory considerations for EDCs -- Green chemistry principles in the designing and screening for safe chemicals and remediation of EDCs.
  • Digital
    Jose Russo, editor.
    Springer2011
    Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
  • Digital
    edited by Donna L. Mendrick, William B. Mattes.
    Springer Protocols2008
    Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
  • Digital
    Michael D. Coleman.
    Wiley2014
    A brief history of occupational toxicology -- The expert report process in legal context -- Acute toxicity : case histories of solvent exposure -- Chronic and permanent injury : bladder cancer and occupation -- Chronic and acute toxicity of herbicides and pesticides -- Toxicity of imported goods.
  • Digital
    I. Mader, P.R. Fürst-Weger, R.M. Mader, E. Nogler-Semenitz, S. Wassertheurer.
    Springer2010
  • Digital
    Jennifer Ann Dougherty.
    The contamination of water supplies by organic contaminants such as pharmaceuticals and personal care products (PPCPs) pose a potential risk to the health of humans and ecosystems. Septic systems under the best circumstances produce effluent quality equivalent to biologically or secondarily treated wastewater, which is known to be inefficient for removal of many PPCPs. This dissertation examines septic systems as a source of PPCP pollution. The occurrence, fate, and transport of a set of 25 organic contaminants commonly found in wastewater was studied at the scale of a watershed, a septic system, and in microcosms that simulated the geochemical conditions of a septic plume. The septic system study was carried out at Stinson Beach, CA and the watershed study at Liberty Bay, WA. The tested compounds included 19 pharmaceuticals, three personal care products, two herbicides and one flame retardant. They encompassed a structurally diverse group of chemicals with a wide range of physicochemical properties, with Log Kow ranging -0.07 to 4.77 as well as acidic and basic properties. First, sediments from Stinson Beach, CA were used in batch microcosm experiments to assess biotransformation and sorption under conditions simulating an aerobic groundwater system and the nitrate and sulfate reducing conditions of a septic plume. Transformation was found, in general, to be slower under anaerobic conditions than aerobic conditions. Half-lives ranged from 4 days to longer than 365 days for all conditions. Sorption did not fit the commonly used hydrophobic models governed by Log Kow, indicating the significance of factors other than hydrophobicity. These factors may include hydrogen bonding and electrostatic attraction due to one or several polar functional groups. Second, the occurrence and transport of PPCPs in a single septic system along the California coast was documented. Findings indicated that many PPCPs were refractory and mobile under the conditions of a leach field contaminant plume. Finally, in a watershed scale study in Liberty Bay, Washington, the occurrence of PPCPs thought to originate from septic systems was evaluated. The findings are consistent with laboratory data and usage patterns. The overall results of this dissertation suggest that septic systems, which support 25% of the United States population, may be a significant source of PPCP contamination to groundwater and surface waters.
  • Digital
    edited by Om V. Singh.
    Wiley2017
  • Digital
    Ijeoma F. Uchegbu, Andreas G. Schätzlein, Woei Ping Cheng, Aikaterini Lalatsa, editors.
    Springer2013
    Nanoscience and nanotechnology overview -- Liposome preparation and characterization -- Solid polymeric nanoparticles -- Lipid nanoparticles -- Polymeric vesicles -- Low molecular weight amphiphile micelles -- Polymeric micelles -- Niosomes -- Quantum dots -- Magnetic particles -- Drug nanoparticles -- Polymeric pro-drugs -- Therapeutic Applications of pharmaceutical nanosystems -- Drug solubilisation -- Gene therapy -- Chemotherapy -- Tissue engineering -- Anti-infectives -- Vaccination -- Anti-arthritic drugs -- Imaging agents -- Commercial exploitation of pharmaceutical nanosystems -- Future perspectives -- Multiple Choice -- Problem Sets -- Case Studies -- Suggested Reading.
  • Digital
    Wanda M. Haschek, Brad Bolon, Colin G. Rousseaux, Matthew A. Wallig.
    ScienceDirect2017
  • Digital
    edited by Duarte Miguel F. Prazeresl, Sofia Aires M. Martins.
    Springer Protocols2015
    G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins -- Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others] -- Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others] -- Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer -- cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others] -- Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst -- Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith -- Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner -- Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah -- GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas -- Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres -- Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others] -- Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others] -- Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis -- Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others] -- Label-free functional selectivity assays / Ann M. Ferrie [and others] -- Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl -- Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others] -- Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].
  • Digital
    edited by James M. Parry and Elizabeth M. Parry.
    Springer Protocols2012
    The application of structure-activity relationships to the prediction of the mutagenic activity of chemicals / Philip Judson -- Bacterial mutagenicity assays : test methods / David Gatehouse -- The mouse lymphoma assay / Melvyn Lloyd and Darren Kidd -- Mammalian cell HPRT gene mutation assay : test methods / George E. Johnson -- The in vitro mammalian chromosome aberration test / Gill Claire -- The interpretation and analysis of cytogenetic data / Natalie Danford -- The in vitro micronucleus assay / Ann T. Doherty -- The in vitro and in vivo comet assays / Brian Burlinson -- Assessment of DNA interstrand crosslinks using the modified alkaline comet assay / Jian Hong Wu and Nigel J. Jones -- 32P-postlabelling for the sensitive detection of DNA adducts / Nigel J. Jones -- Methods for the detection of DNA adducts / Karen Brown -- The GADD45a-GFP GreenScreen HC assay / Richard M. Walmsley and Matthew Tate -- Real-time reverse-transcription polymerase chain reaction : technical considerations for gene expression analysis / Shareen H. Doak and Zoulikha M. Zaïr -- Cytogenetic in vivo assays in somatic cells / Ann T. Doherty, Adi Baumgartner, and Diana Anderson -- Cytogenetic methods in human biomonitoring : principles and uses / Raluca A. Mateuca, Ilse Decordier, and Micheline Kirsch-Volders -- The measurement of induced genetic change in mammalian germ cells / Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo -- Transgenic animal mutation models : a review of the models and how they function / Steve Dean -- Analysis of genotoxicity data in a regulatory context / Ian de G. Mitchell and David O.F. Skibinski.
  • Digital
    edited by L. María Sierra, Isabel Gaivão.
    Springer Protocols2014
    Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
  • Digital
    edited by Alok Dhawan, Mahima Bajpayee.
    Springer Protocols2013
    Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
  • Digital
    Jan Willem van der Laan, Joseph J. DeGeorge, editors.
    Springer2013
    The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
  • Digital
    [edited by] Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S. Nelson, Lewis R. Goldfrank ; editor emeritus Neal E. Flomenbaum.
    AccessEmergency Medicine2015
    Pt. A: The general approach to medical toxicology -- Pt. B: The fundamental principles of medical toxicology -- Sect. I: Biochemcial and molecular basis -- Sect. II: Pathophysiologic basis: organ systems -- Sect. III: Special populations -- Pt. C: The clinical basis of medical toxicology -- Sect. I: A: Analgesics and antinflammatory medications -- B: Food, diet, and nutrition -- C: Pharmaceuticals -- D: Antimicrobials -- E: Cardiopulmonary medications -- F: Anesthetics and related medications -- G: Psychotropics -- H: Substances of abuse -- I: Metals -- J: Household products -- K: Pesticides -- L: Natural toxins and envenomations -- M: Occupational and environmental toxins -- N: Disaster preparedness -- Sect. II: Poison centers and epidemiology.
  • Digital
    Denis J. Dupré, Terence E. Hébert, Ralf Jockers, editors.
    Springer2012
    ER-bound steps in the biosynthesis of G protein-coupled receptors / Christian Nanoff and Michael Freissmuth -- Role of chaperones in G Protein coupled receptor signaling complex assembly / Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- GPCR oligomerization: contribution to receptor biogenesis / Kathleen Van Craenenbroeck -- The functional size of GPCRs: monomers, dimers or tetramers? / Darlaine Pétrin and Terence E. Hébert -- Regulation of post-Golgi traffic of G protein-coupled receptors / Guangyu Wu -- Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- Regulatory processes governing the cell surface expression of LH and FSH receptors / Deborah L. Segaloff -- Chaperone-mediated assembly of G protein complexes / Barry M. Willardson and Christopher M. Tracy -- Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / Jane Dingus and John D. Hildebrandt -- Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / Janet D. Robishaw -- G Protein trafficking / Philip B. Wedegaertner -- Differential assembly of GPCR signaling complexes determines signaling specificity / Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- GPCR and voltage-gated calcium channels (VGCC) signaling complexes / Christophe Altier -- Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
  • Digital
    edited by Raymond D. Harbison, Marie M. Bourgeois, and Giffe T. Johnson.
    Wiley2015
  • Digital
    edited by William Slikker, Jr., Merle G. Paule, Cheng Wang.
    ScienceDirect2018
    Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.
  • Digital
    editors, Saura C. Sahu, Daniel A. Casciano.
    Wiley2014
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2009
  • Digital
    edited by Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon, Ricardo Ochoa ; Beth W. Mahler (illustrations editor).
    ScienceDirect2013
    ClinicalKey2013
  • Digital
    edited by Robert I. Krieger.
    ScienceDirectv. 1-2, 2010
    The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
  • Digital
    Meenakshisundaram Ramachandran, editor ; P. Thirumalaikolundusubramanian, assistant editor.
    ScienceDirect2015
    Epidemiology of cardiovascular toxins / Churchill Lukwiya Onen -- Cellular and molecular perspectives on cardiac toxins / Reza Tabrizchi -- Environmental toxins and the heart / Sahand Rahnama-Moghadam, L. David Hillis, and Richard A. Lange -- Problems and paradoxes of animal toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Plant toxins and the heart / Subramanian Senthilkumaran, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Native medicines and cardiovascular toxicity / Ashish Bhalla, [et al.] -- Cardiovascular toxicity from marine envenomation / Benjamin Seymour, Athena Andreosso, and Jamie Seymour -- Cardiovascular toxicity of cardiovascular drugs / Ramachandran Meenakshisundaram, [et al.] -- Cardiovascular toxicity as a result of psychotropic drugs / Mythily Subramaniam, [et al.] -- Cardiovascular toxicity of noncardiovascular drugs / Omi Bajracharya, P. Ravi Shankar, and Nisha Jha -- Cardiovascular toxicity from chemotherapy and anticancer treatment / Angela Esposito, [et al.] -- Association of human immunodeficiency virus infection with exposure to highly active antiretroviral therapy and its adverse cardiovascular effects / Steven E. Lipschultz, [et al.] -- Toxic effects of alcohol on the heart / Subroto Acharjee, Bhaskar Purushottam, and Vincent M. Figueredo -- The effects of active and passive smoking and cardiovascular disease / Mahmood Ahmad, Emmanuel Selvaraj, and Ramachandran Meenakshisundaram -- Cardiovascular toxicity as a result of recreational drugs / Rohin Francis and Azad Ghuran -- Pediatric cardiovascular toxicity : special considerations / Jennifer A. Lowry -- Cardiovascular toxicity as a result of radiological imaging / Shah Sweni, Ramachandran Meenakshisundaram, and Ponniah Thirumalakolundusubramanian -- Nanomaterials and cardiovascular toxicity / Arghya Paul, [et al.] -- Forensic pathology related to cardiovascular toxicity / Magdy A. Kharoshah, [et al.] -- Ethics, legality, and education in the practice of cardiology / Ponniah Thirumalakolundusubramanian, Ramachandran Meenakshisundaram, and Subramanian Senthilkumaran.
  • Digital
    edited by Pablo Steinberg.
    Wiley2013
    pt. 1. General aspects -- pt. 2. High-throughput assays to assess different cytotoxicity endpoints -- pt. 3. High-throughput assays to assess DNA damage and carcinogenesis -- pt. 4. High-throughput assays to assess reproductive toxicity, cardiotoxicity, and haematotoxicity -- pt. 5. High-throughput assays to assess drug metabolism and receptor-related toxicity.
  • Print
    Lucile Packard Children's Hospital.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Harold Zeliger.
    ScienceDirect2011
    In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog). A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists. . New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures.
  • Digital
    Hideo Kimura, editor.
    Springer2013
    The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900s. Three enzymes, cystathionine synthase (CBS), cystathionine lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
  • Digital
    K.D. Rainsford.
    Springer2012
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • Digital
    edited by Franz-Xaver Reichl, MD, Professor, Department of Operative/Restorative Dentistry, Periodontology, and Pedodontics, Ludwig Maximilian University, Munich, Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Germany, Leonard Ritter, MD, Professor, School of Environmental Sciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada ; with contributions by Jochen Benecke [and thirteen others].
    Thieme MedOne Education2011
    This book serves as a hands-on guide to various poison treatments and offers supplemental public health information. Each two-page unit features concise text on the left complemented by full-color illustrations on the opposing page. The expert author distinguishes harmful toxic substances and catalogues their specific effects on the human body, plants, animals, and the surrounding environment. The handbook also addresses other topics, including biological warfare, modern toxicological methods, and threshold values. Features include: succinct, user-friendly organization so readers can navigate the content with ease; over 600 detailed images and diagrams arranged on 150 full-color plates illustrate exposures and toxicological effects on humans, plants, and animals; well-researched, objective risk analysis on toxic exposures accompanied by relevant images; extensive glossary of key toxicological terms that provide readers with the accurate information they need to avoid dangerous confusion.
  • Digital
    J. Descotes.
    ScienceDirectv.1, 2004
    v. 1. Principles and methods of immunotoxicology.
  • Digital
    edited by Lucio G. Costa, Gennaro Giordano, Marina Guizzetti.
    Springer Protocols2011
    In vitro neurotoxicology : an introduction / Lucio G. Costa, Gennaro Giordano, and Marina Guizzetti -- Primary neurons in culture and neuronal cell lines for in vitro neurotoxicological studies / Gennaro Giordano and Lucio G. Costa -- Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary cultures / Evelyn Tiffany-Castiglioni [and others] -- Microglia cell culture: a primer for the novice / Anke Witting and Thomas Möller -- Neural stem cells for developmental neurotoxicity studies / Roshan Tofighi [and others] -- Preparation, maintenance, and use of serum-free aggregating brain cell cultures / Paul Honegger [and others] -- Neurospheres as a model for developmental neurotoxicity testing / Ellen Fritsche, Kathrin Gassmann, and Timm Schreiber -- Acute hippocampal slice preparation and hippocampal slice Cultures / Pamela J. Lein, Christopher D. Barnhart, and Isaac N. Pessah -- Glia-neuron sandwich cocultures : an in vitro approach to evaluate cell-to-cell communication in neuroinflammation and neurotoxicity / ariaserena Boraso and Barbara Viviani -- In vitro models to study the blood brain barrier / Hilary Vernon, Katherine Clark, and Joseph P. Bressler -- Measurements of cell death in neuronal and glial cells / Gennaro Giordano [and others] -- Measurements of neuronal apoptosis / Gennaro Giordano and Lucio G. Costa -- Measurement of isoprostanes as markers of oxidative stress / Dejan Milatovic, Thomas J. Montine, and Michael Aschner -- Assessment of glutathione homeostasis / Gennaro Giordano, Collin C. White, and Lucio G. Costa -- Assessing neuronal bioenergetic status / Stephanie L.H. Zeiger, Jeannette N. Stankowski, and BethAnn McLaughlin -- Fluorescent assessment of intracellular calcium in individual cells / David P. Cox, Collin C. White, and Terrance J. Kavanagh -- Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures / Victor Briz and Cristina Suñol -- Detection of nitric oxide formation in primary neural cells and tissues / Ronald B. Tjalkens, David L. Carbone, and Guoyao Wu -- JNK3-mediated apoptotic cell death in primary dopaminergic neurons / Won-Seok Choi, Heather M. Klintworth, and Zhengui Xia -- Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration / Faneng Sun, Anumantha G. Kanthasamy, and Arthi Kanthasamy -- Cell signaling and neurotoxicity : protein kinase C in vitro and in vivo / Prasada Rao S. Kodavanti -- Cell signaling and neurotoxicity : 3H-arachidonic acid release (phospholipase A2) in cerebellar granule neurons / Prasada Rao S. Kodavanti -- Quantitative assessment of neurite outgrowth in PC12 cells / Joshua A. Harrill and William R. Mundy -- Measurements of astrocyte proliferation / Marina Guizzetti, Terrance J. Kavanagh, and Lucio G. Costa -- Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons / Pamela J. Roqué [and others] -- Volume measurements in cultured primary astrocytes / Michael Aschner -- Assessment of cholesterol homeostasis in astrocytes and neurons / Jing Chen, Lucio G. Costa, and Marina Guizzetti -- Dose-response or dose-effect curves in in vitro experiments and their use to study combined effects of neurotoxicants / Matteo Goldoni and Sara Tagliaferri.
  • Digital
    edited by Anna Bal-Price, Paul Jennings.
    Springer Protocols2014
    In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
  • Digital
    edited by Philip Wexler ; associate editors, Steven G. Gilbert, Pertti J. Hakkinen, Asish Mohapatra.
    ScienceDirect2009
  • Digital/Print
    Digital : IARC2010
    Print2010
    Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • Digital/Print
    Sheffer, Marla.
    Digital : WHO2013
    Print2013
  • Digital
    Philip C. Burcham.
    Springer2014
    This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960?s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that "unpack" the concepts being discussed in the text.
  • Digital
    edited by Bernhard Kuster.
    Springer Protocols2012
    Targeting cancer with small-molecular-weight kinase inhibitors / Doriano Fabbro [and others] -- Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation / Matthias Gaestel and Alexey Kotlyarov -- Measuring the activity of leucine-rich repeat kinase 2 : a kinase involved in Parkinson's disease / Byoung Dae Lee [and others] -- Measuring P13K lipid kinase activity / Elisa Ciraolo, Alessia Perino, and Emilio Hirsch -- A fluorescence polarization assay for the discovery of inhibitors of the polo-box domain of polo-like kinase 1 / Wolfgang Reindl, Klause Strebhardt, and Thorsten Berg -- Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology / Jinghai J. Xu [and others] -- Kinase inhibitor selectivity profiling using differential scanning fluorimetry / Oleg Fedorov, Frank H. Niesen, and Stefan Knapp -- Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP / James S. Duncan, Timothy A.J. Haystead, and David W. Litchfield -- Proteome-wide identification of staurosporine-binding kinases using capture coumpound mass spectrometry / Jenny J. Fischer, Olivia Y. Graebner (neé Baessler), and Mathias Dreger -- Affinity pruification of proteins binding to kinase inhibitors immobilized on self-assembling monolayers / Marcus Bantscheff, Scott Hobson, and Bernhard Kuster -- Kinase inhibitor profiling using chemoproteomics / Markus Schirle [and others] -- Covalent cross-linking of kinases with their corresponding peptide substrates / Alexander V. Statsuk and Kevan M. Shokat -- Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays / Oliver Pötz [and others] -- Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays / Gabriela Lavezzari and Mark R. Lackner -- Measuring phosphorylation-specific changes in response to kinase inhibitors in mammalian cells using quantitative proteomics / Nurhan Özlü, Marc Kirchner, and Judith Jebanathirajah Steen -- Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays / Kian Kani, Rafaella Sordella, and Parag Mallick.
  • Digital
    Website : NLM
    Includes workbook: TOXNET & Beyond-- Using the National Library of Medicine® Environmental Health & Toxicology Portal.
  • Digital
    Raymond Chuen-Chung Chang, Kwok-Fai So, editors.
    Springer2015
    1. Chemical and genetic diversity of Wolfberry -- 2. Immunoregulation and Lycium Barbarum -- 3. The antioxidant, anti-inflammatory, and antiapoptotic effects of Wolfberry in fatty liver disease -- 4. Effectts of Lycium barbarum on modulation of blood vessel and hemodynamics -- 5. Dermatologic uses and effects of Lycium barbarum -- 6. Lycium Barbarum and tumors in the gastrointestinal tract -- 7. Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum -- 8. Prosexual effects of Lycium Barbarum -- 9. Lycium Barbarum: neuroprotective effects in ischemic stroke -- 10. Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium Barbarum (Wolfberry) -- 11. Role of Lycium Barbarum extracts in retinal diseases -- 12. Allergenic sensitisation mediated by Wolfberry.
  • Digital
    Bernd Nilius, Veit Flockerzi, editors.
    Springerv. 1
    Springerv. 2
    v. 1. TRPs: truly remarkable proteins -- The TRCP subfamily -- TRPC1 -- TRPC2 -- TRPC3: a multifunctional signaling molecule -- TRPC4 and TRPC4-containing channels -- TRPC5 -- TRPC6: physiological function and pathophysiological relevance -- Transient receptor potential canonical 7 (TRPC7) -- The TRPV subfamily -- TRPV1 -- TRPV2 -- TRPV3 -- The TRPV4 channel -- TRPV5, a Ca2+ channel for the fine tuning of Ca2+ reabsorption -- TRPV6 channels -- The TRPM subfamily -- TRPM1 -- TRPM2 -- TRPM3 -- TRPM4 -- TRPM5 -- TRPM6 -- TRPM7 -- TRPM8 -- The TRPA1, TRPML and TRPP subfamily -- TRPA1 -- TRPML1: an ion channel in the lysosome -- TRPML2 and mucolipin evolution -- TRPML3 -- TRPP subfamily and polycystin-1 proteins -- v. 2. TRPs as special cell sensors -- Temperature sensing with TRPs -- TRPs in mechano-sensing and volume regulation -- TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) -- Photosensitive TRPs -- TRPs in taste and chemesthesis -- TRPs and Pain -- TRPs in hearing -- TRPs in olfaction -- General topics -- Evolutionary conserved, multitasking TRP channels-lessons from worms and flies -- Structural biology of TRP channels -- High-resolution views of TRPV1 and their implications for the TRP channel superfamily -- Physiological functions and regulation of TRPC channels -- The TRPCs-STIM1-orai interaction -- The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins -- TRPs: modulation by drug-like compounds -- TRP channels in reproductive (neuro)endocrinology -- Modulation of TRP ion channels by venomous toxins -- Phosphoinositide regulation of TRP channels -- TRP modulation by natural compounds -- What do we really know and what do we need to know: some controversies, perspectives, and surprises.
  • Digital
    Rudolph M. Navari, editor.
    Springer2016
    1. Introduction -- 2. The physiology and pharmacology of nausea and vomiting induced by anticancer chemotherapy in humans -- 3. First-generation 5-HT3 receptor antagonists -- 4. Palonosetron -- 5. The role of neurokinin-1 receptor antagonists in CINV -- 6. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting -- 7. Gabapentin for the prevention of CINV -- 8. Prevention of CINV in patients receiving high-dose multiple-day chemotherapy -- 9. Clinical management of CINV -- 10. Treatment of chemotherapy-induced nausea -- 11. Conclusions -- 12. Future directions.
  • Print
    edited by Hongbo Zhai, Klaus-Peter Wilhelm, Howard I. Maibach.
    Status: Not Checked OutLane Catalog Record
    Evaluting efficacy of barrier creams: in vitro and in vivo models -- Light-induced dermal toxicity: effects on cellular and molecular levels -- Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products -- Exogenous ochronosis: update -- Diagnostic patch test: science and art -- Irritant and allergic contact dermatitis treatment -- Factors affecting children's susceptibility to chemicals -- Utilization of irritation data in local lymph node assay -- Air bag injuries -- Cigarette smoking and skin -- Chemical analysis of tattoo pigments cleaved by laser light -- Dermatotoxicology of specialized epithelia: adapting cutaneous test methods to assess topical effects on vulva -- Anti-irritants: myth or reality? overview -- Evaluating mechanical and chemical irritation using the behind-the-knee tests: review -- Need for more sensitive tools as we reach limits of our ability to detect differences in skin effects from mild products -- Drug patch testing in systemic cutaneous drug allergy -- Hormesis and dermatology -- Diagnosis of drug hypersensitivity in vitro -- Immunologic patterns in allergic and irritant contact dermatitis: similarities -- Water decontamination of chemical skin and eye splashes: critical review -- Chemical substances and contact allergy: 244 substances ranked according to allergenic potency -- Use of modified forearm controlled application test to evaluate skin irritation of lotion formulations -- Hair in toxicology -- Popliteal lymph node assay -- Pigmentation changes resulting from arsenic exposure -- Textiles and human skin, microclimate, cutaneous reactions: overview -- In vivo human transfer of topical bioactive drugs among individuals: estradiol -- Is there evidence that geraniol causes allergic contact dermatitis? -- Operational definition of a causative contact allergen-study with six fragrance allergens -- Sodium lauryl sulfate-induced irritation in human faces: regional- and age-related differences -- Classification of irritant contact dermatitis -- In vitro skin irritation testing on SkinEthic[tm]-reconstituted human epidermis: reproducibility for fifty chemicals tested with two protocols -- Identifying source of textile-dye allergic contact dermatitis: guidelines -- Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate -- Is contact allergy lifelong in humans? an overview of patch-test follow-ups -- Irritants in combination with synergistic or additive effect on skin response overview of tandem irritation studies -- Allergic contact dermatitis from iodine preparations: a conundrum? -- Human skin buffering capacity: oveview. Pesticide percutaneous absorption and decontamination -- Tape stripping method versus stratum corneum -- Parameters influencing stratum corneum removal by tape stripping -- Quantification of stratum corneum removed by tape stripping -- Isolated perfused porcine skin flap -- Physiologically based pharmacokinetic modeling -- Methods for in vitro skin metabolism studies -- Predicitive toxicology methods for transdermal delivery systems -- Animal, human, and in vitro test methods for predicting skin irritation -- Kawaki method for testing irritation -- Analysis of structural change in intercellular lipids of humam stratum corneum induced by surfactants: electron paramagnetic resonance (EPR) study -- Water and saline compresses in treatment of irritant contact dermatitis: literature review -- Reaction of skin blood vessels to successive insults on normal and irritated human skin -- Specificity of retinoid-induced irritation and its role in clinical efficacy -- Topical corticosteroids in the treatment of irritant dermatitis: do they work? -- Tests for sensitive skin -- Test methods for allergic contact dermatitis in animals -- Test methods for allergic contact dermatitis in humans -- Allergic contact dermatitis: elicitation thresholds of potent allergens in humans -- Allergic contact dermatitis to topical anesthetics: a cross-sensitization phenomenon -- Contact urticaria and anaphylaxis to chlorhexidine: overview -- Immunoadjuvants in prospective testing for contact allergens -- Local lymph node assay -- Iontophresis in humans: regional variations in skin barrier function and cutaneous irritation -- Contact urticaria and contact urticaria syndrome (immediate contact reactions) -- In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials -- Photoirritation (phototoxicity) testing in humans -- Measuring and quantifying ultraviolet radiation exposures -- Determination of subclinical changes of barrier function -- Assessing validity of alternative methods for toxicity testing: role and activities of ECVAM -- Animal models of contact urticaria -- Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria -- Cosmetic reactions -- Decreasing allergic contact dermatitis frequency through dermatotoxicologic- and epidemiologic-based intervention? -- Cutaneous corticosteroid-induced glaucoma -- Pharmacogenetics and dermatology -- Ethnic differences in skin properties: objective data -- Occlusion and barrier function -- Anatomical factors affecting barrier function -- Percutaneous penetration enhancers: overview -- Percutaneous absorption of complex chemical mixtures -- Percutaneous absorption: short-term exposure, lag time, multiple exposures, model variations, and absorption from clothing -- Percutaneous absorption: 7 roles of lipids -- Chemical partitioning into powdered human stratum corneum: a useful in vitro model for studying interactions of chemicals and human skin -- Sensitive skin -- Transdermal drug delivery system: an overview -- Transdermal drug delivery system: an overview -- Iontophoresis: from historical perspective to its place in modern medicine -- Irritant dermatitis: clinical heterogeneity and contributing factors -- Systemic contact dermatitis -- Allergic contact dermatitis -- Mechanisms in irritant and allergic contact dermatitis -- Occupational allergic contact dermatitis: rational work-up -- Systemic toxicity -- Concepts in molecular dermatotoxicology -- Molecular basis of allergic contact dermatitis -- Photoirritation (phototoxicity, phototoxic dermatitis) -- Permeability of skin to metal compounds, with focus on nickel and copper -- Chemically induced scleroderma -- Chemical agents that cause depigmentation -- Carcinogenesis: current trends in skin cancer research -- Retinoids and mechanisms of their toxicity -- Mechanisms in cutaneous drug hypersensitivity reactions -- Drug-induced ocular phototoxicity -- Water: is it an irritant? -- Sodium lauryl sulfate -- Factors influencing applied amounts of topical preparations -- Barrier creams -- OECD guidelines for testing of chemicals -- Methods for in vitro percutaneous absorption -- Percutaneous absorption of hazardous substances from soil and water --
  • Digital
    edited by Jerry Zweigenbaum.
    Springer Protocols2011
    European union regulations / Peter Furst -- China's food safety regulation and mass spectrometry / Xiaogang Chu [and others] -- United States and Japanese food regulations / Jerry Zweigenbaum -- QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods / Steven J. Lehotay -- Automated solid phase extraction / Norbert Helle, Meike Baden, and Kaj Petersen -- Multiresidue pesticide analysis by capillary gas chromatography-mass spectrometry / Jon W. Wong [and others] -- Targeted pesticide residue analysis using triple quad LC-MS/MS / Lutz Alder -- LC/TOF-MS analysis of pesticides in fruits and vegetables : the emerging role of accurate mass in the unambiguous identification of pesticides in food / Imma Ferrer, E. Michael Thurman, and Jerry Zweigenbaum -- Hormone analysis in food products / Marco H. Blokland and Saskia S. Sterk -- Analysis of multiple mycotoxins in food / Jana Hajslova, Milena Zachariasova, and Tomas Cajka -- Multi mycotoxin analysis in food products using immunoaffinity extraction / Masahiko Takino, Hiroki Tanaka, and Toshitsugu Tanaka -- Multiresidue analysis of antibiotics in food of animal origin using liquid chromatography-mass spectrometry / Katerina Mastovska -- LC-MS/MS methods for the determination of specific antibiotics residues in food matrices / Gui-Liang Chen and Yan-Yan Fang -- Identification of unknown migrants from food contact materials / Malcolm Driffield [and others] -- Halogenated persistent organic pollutants and polycyclic aromatic hydrocarbons in food / Tomas Cajka and Jana Hajslova.
  • Digital
    edited by Pavel Anzenbacher and Ulrich M. Zanger.
    Wiley2012
    Biochemistry and molecular genetics of drug metabolism -- Drug-metabolizing enzymes: an overview -- Cytochromes P450 -- UDP-glucuronosyltransferases -- Sulfotransferases -- Glutathione s-transferases -- Hydrolytic enzymes -- Transporting systems -- Transcriptional regulation of human drug-metabolizing cytochrome P450 enzymes -- Importance of pharmacogenomics -- Metabolism of drugs -- Introduction to drug metabolism -- Central nervous system drugs -- Cardiovascular drugs -- Anticancer drugs -- Antimicrobial agents -- Drugs against acute and chronic pain -- Drugs of abuse (including designer drugs) -- Nicotine metabolism and its implications -- Metabolism of alcohol and its consequences -- Metabolism of natural compounds -- Introduction and overview -- Food components and supplements -- Metabolism of unnatural xenobiotics -- Environmental pollutants -- Environmental estrogens -- Biotransformation of insecticides.
  • Digital
    Sandra Ceccatelli, Michael Aschner, editors.
    Springer2012
    Annotation Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHgs accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This bookwill provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
  • Digital
    editor-in-chief: Jeffrey K. Aronson.
    ClinicalKey2017
  • Digital/Print
    Lang Tran, Miguel A. Bañares, Robert Rallo, editors.
    Digital : Springer2017
    Print2017
    In today's nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.
  • Digital
    edited by Andreas Luch.
    Springer2009
  • Digital
    edited by Andreas Luch.
    Springer2010
  • Digital
    edited by Andreas Luch.
    Springer2012
    Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Digital
    edited by Phouthone Keohavong, Stephen G. Grant.
    Springer Protocols2014
    Array-Based Immunoassays with Rolling-Circle Amplification Detection -- Analysis of Protein Changes Using Two-Dimensional Difference Gel Electrophoresis -- Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage -- Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System -- Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques -- Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR) -- Strategies for Measurement of Biotransformation Enzyme Gene Expression -- Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening -- TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material -- 32P-Postlabeling Analysis of DNA Adducts -- Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot -- DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry -- Analysis of DNA Strand Cleavage at Abasic Sites -- Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes Without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization Probes -- Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk -- Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair -- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice -- The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay -- Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and Mice -- Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. (Continued) -- Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model Systems -- The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic Mutation -- Molecular Analysis of Mutations in the Human HPRT Gene -- Simultaneous Quantification of t(14; 18) and HPRT Exon 2/3 Deletions in Human Lymphocytes -- Mutation Screening of the TP53 Gene by Temporal Temperature Gel Electrophoresis (TTGE) -- Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples -- ACB-PCR Quantification of Somatic Oncomutation -- Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection: Limitations and Solutions -- Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions -- Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells -- The Sister Chromatid Exchange (SCE) Assay -- The Gene Cluster Instability (GCI) Assay for Recombination -- Measuring Recombination Proficiency in Mouse Embryonic Stem Cells -- Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery -- Unscheduled DNA Synthesis: The Clinical and Functional Assay for Global Genomic DNA Nucleotide Excision Repair -- Analysis of Actively Transcribed DNA Repair Using a Transfection-Based System -- An Immunoassay for Measuring Repair of UV Photoproducts -- Analysis of Double-Strand Break Repair by Nonhomologous DNA End Joining in Cell-Free Extracts from Mammalian Cells -- Bioenergetic Analysis of Intact Mammalian Cells Using the Seahorse XF24 Extracellular Flux Analyzer and a Luciferase ATP Assay -- Quantification of Selective Phosphatidylserine Oxidation During Apoptosis -- Quantitative Method of Measuring Phosphatidylserine Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron -- Detection of Programmed Cell Death in Cells Exposed to Genotoxic Agents Using a Caspase Activation Assay.
  • Digital
    Marie-Odile Parat, editor.
    Springer2013
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Digital
    edited by Ashutosh Kumar, Vasily N. Dobrovolsky, Alok Dhawan, Rishi Shanker.
    ScienceDirect2018
  • Digital
    edited by Joshua Reineke.
    Springer Protocols2012
    Historical overview of nanotechnology and nanotoxicology -- Characterization of nanomaterials for toxicological studies -- Methods for understanding the interaction between nanoparticles and cells -- Single-cell gel electrophoresis (comet) assay in nano-genotoxicology -- Single-cell nanotoxicity assays of superparamagnetic iron oxide nanoparticles -- Western blot analysis -- Application of reverse transcription-PCR and real-time PCR in nanotoxicity research -- Deriving TC(50) values of nanoparticles from electrochemical monitoring of lactate dehydrogenase activity indirectly -- Enzyme-linked immunosorbent assay of IL-8 production in response to silver nanoparticles -- Metabolomics techniques in nanotoxicology studies -- Nanoparticle uptake measured by flow cytometry -- Determining biological activity of nanoparticles as measured by flow cytometry -- Whole cell impedance biosensoring devices -- Free energy calculation of permeant-membrane interactions using molecular dynamics simulations -- Screening of fullerene toxicity by hemolysis assay -- Assessment of in vitro skin irritation potential of nanoparticles: RHE model -- In vivo methods of nanotoxicology -- The luminescent bacteria test to determine the acute toxicity of nanoparticle suspensions -- The primacy of physicochemical characterization of nanomaterials for reliable toxicity assessment: A review of the zebrafish nanotoxicology model -- Application of embryonic and adult zebrafish for nanotoxicity assessment -- Applications of subsurface microscopy -- Application of ICP-MS for the study of disposition and toxicity of metal-based nanomaterials -- Quantitative nanoparticle organ disposition by gel permeation chromatography -- Physiologically based pharmacokinetic modeling for nanoparticle toxicity study -- Biophysical methods for assessing plant responses to nanoparticle exposure -- In vivo nanotoxicity assays in plant models.
  • Digital
    edited by Satyajit D. Sarker, Lutfun Nahar.
    Springer Protocols2012
    An introduction to natural products isolation -- Initial and bulk extraction of natural products isolation -- Supercritical fluid extraction in natural products analyses -- Accelerated solvent extraction for natural products isolation -- Microwave-assisted extraction in natural products isolation -- An introduction to planar chromatography and its application to natural products isolation -- Isolation of natural products by low-pressure column chromatography -- Isolation of natural products by ion-exchange methods -- Separation of natural products by countercurrent chromatography -- Isolation of natural products by preparative high performance liquid chromatography (prep-HPLC) -- Isolation of natural products by preparative gas chromatography -- Hyphenated techniques and their applications in natural products analysis -- Extraction of plant secondary metabolites -- Isolation of marine natural products -- Isolation of microbial natural products -- Extraction and isolation of saponins -- Extraction and isolation of phenolic compounds -- Scaling-up of natural products isolation -- Follow-up of natural products isolation -- Natural products isolation in modern drug discovery programs.
  • Digital
    Jiří Bajgar.
    ScienceDirect2012
    Chemical weapons -- Chemical warfare agents -- Organophosphates and nerve agents -- Toxicodynamics -- Antidotal treatment -- Prophylaxis.
  • Digital
    Daniel Thomas Ginat, Juan E. Small, Pamela Whitney Schaefer, editors.
    Springer2015
    This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.
  • Digital
    Richard M. Kostrzewa, Trevor Archer, editors.
    Springer2016
    From the contents: Preface -- ADHD Modeling by Perinatal Insult in Animals -- Perinatal Insults to Model Human Neuro-Psychiatric Disorders -- Selective Life-long Destructive of Brain Monoaminergic Nerves -- NGF in Perinatal Development -- Life-long Susceptibility Consequent to Perinatal Substances of Abuse -- Schizotypic Effects of Perinatal Insults.
  • Digital
    Soodabeh Saeidnia.
    Springer2015
    This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also℗ℓincludes discussion of℗ℓnew areas℗ℓsuch as℗ℓbiotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have℗ℓbeen the subject of discussion℗ℓin this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
  • Digital/Print
    edited by Michael Balls, Robert D. Combes, Nirmala Bhogal.
    Digital : Springer2012
    Print2012
    Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening : microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro systems / Daniel A. Casciano -- The use of integrated and intelligent testing strategies in the prediction of toxic hazard and in risk assessment / Michael Balls, Robert D. Combes, and Nirmala Bhogal.
  • Digital
    Emilija Veljkovic, Wenhao Xia, Blaine Phillips, Ee Tsin Wong, Jenny Ho, Alberto Oviedo, Julia Hoeng, Manuel Peitsch.
    ScienceDirect2018
    Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Tourette's syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.
  • Digital/Print
    Peter M. Eller, editor.
    Digital : Google Books1984-
  • Digital
  • Digital
    Mark A. Geyer, Gerhard Gross, editors.
    Springer2012
    This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • Digital
    Rakesh Kumar, editor.
    Springer2014
    Preface -- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression -- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer -- RUNX2 Transcriptional Regulation in Development and Disease -- Epigenetic Mechanisms of Cancer Metastasis -- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications -- Nuclear Factors Linking Cancer and Inflammation -- Regulation of the Jak/STATs Pathways by Histone Deacetylases -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers -- Nucleolar Signaling Determines Cell Fate The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment -- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology -- Domain Specific Targeting of Cancer -- The Potential of Targeting Splicing for Cancer Therapy -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies -- Histone Demethylases in Prostate Cancer -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer -- Index.
  • Print
    Status: Not Checked OutLane Catalog Record
  • Digital
    Klaus Aktories, Joachim H.C. Orth, Ben Adler, editors.
    Springer2012
    Pasteurella multocida: Diseases and Pathogenesis / I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler -- Pathogenomics of Pasteurella multocida / J. D. Boyce, T. Seemann, B. Adler and M. Harper -- The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide / Marina Harper, John D. Boyce and Ben Adler -- Pasteurella multocida and Immune Cells / Katharina F. Kubatzky -- Molecular Biology of Pasteurella multocida Toxin / Joachim H. C. Orth and Klaus Aktories -- Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects / Brenda A. Wilson and Mengfei Ho -- Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin / Yasuhiko Horiguchi -- The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer / Alistair Lax.
  • Digital
    Stephen T. Sonis, Dorothy M. Keefe, editors.
    Springer2013
  • Digital
    edited by Elizabeth McInnes.
    Wiley2017
    An Introduction to Pathology Techniques / Elizabeth McInnes -- Recording Pathology Data / Cheryl L Scudamore -- General Pathology and the Terminology of Basic Pathology / Elizabeth McInnes -- Common Spontaneous and Background Lesions in Laboratory Animals / Elizabeth McInnes -- Target Organ Pathology / Elizabeth McInnes -- Clinical Pathology / Barbara Beust -- Adversity: A Pathologist's Perspective / Bhanu Singh -- Limitations of Pathology and Animal Models / Natasha Neef.
  • Digital
    Gowraganahalli Jagadeesh, Pitchai Balakumar, Khin Maung-U, editors.
    Springer2015
  • Digital
    Robert L. Harris, editor ; contributors, H.E. Ayer ... [et al.].
    Knovel2000
  • Print
    George D. Clayton and Florence E. Clayton, editors ; contributors, M. C. Battigelli ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1. General principles -- v. 2A, Toxicology ; v. 3. Theory and rationale of industrial hygiene practice.
  • Print
    George D. Clayton, Florence E. Clayton, editors ; contributors, R.E. Allan ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1, pt. A-B. General principles -- v. 2, pt. A-F. Toxicology.
  • Digital
    editor, Ernest Hodgson.
    ScienceDirect2012
    Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
  • Digital
    edited by Qing Yan, PharmTao, Santa Clara, CA, USA.
    Springer Protocols2014
    From pharmacogenomics and systems biology to personalized care : a framework of systems and dynamical medicine / Qing Yan -- Translational bioinformatics approaches for systems and dynamical medicine / Qing Yan -- Whole blood transcriptomic analysis to identify clinical biomarkers of drug response / Grant P. Parnell and David R. Booth -- Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies / Raffaele Palmirotta [and six others] -- Approach to clinical and genetic characterization of statin-induced myopathy / QiPing Feng -- Pharmacogenomics of membrane transporters : a review of current approaches / Tristan M. Sissung [and four others] -- G protein-coupled receptor accessory proteins and signaling : pharmacogenomic insights / Miles D. Thompson [and three others] -- G protein-coupled receptor mutations and human genetic disease / Miles D. Thompson [and four others] -- Pharmacogenetics of the G protein-coupled receptors / Miles D. Thompson [and six others] -- Pharmacogenomics of heart failure / Anastasios Lymperopoulos and Faren French -- Pharmacogenomics in the development and characterization of atheroprotective drugs / Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou -- Management of side effects in the personalized medicine era : chemotherapy-induced peripheral neuropathy / Paolo Alberti and G. Cavaletti -- Pharmacogenomics of Alzheimer's disease : novel therapeutic strategies for drug development / Ramón Cacabelos [and four others] -- Pharmacogenetics of antipsychotic treatment in schizophrenia / Jennie G. Pouget and Daniel J. Müller / Pharmacogenetics of addiction therapy / David A. Nielsen [and three others] -- Pharmacogenetics in rheumatoid arthritis / Deepali Sen, Jisna R. Paul, and Prabha Ranganathan -- Pharmacogenetics of osteoporotic fractures / José A. Riancho and Flor M. Pérez-Campo -- Pharmacogenomics and pharmacoepigenomics in pediatric medicine / Barkur S. Shastry -- Pharmacogenomics in children / Michael Rieder.
  • Digital
    Luisa Rocha, Esper A. Cavalheiro, editors.
    Springer2013
    Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
  • Print
    Deborah Blum.
    The untold story of how poison rocked Jazz Age New York City. A pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Chief medical examiner Charles Norris and toxicologist Alexander Gettler investigate a family mysteriously stricken bald, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler create revolutionary experiments to tease out even the wiliest compounds from human tissue. From the vantage of their laboratory it also becomes clear that murderers aren't the only toxic threat--modern life has created a kind of poison playground, and danger lurks around every corner.
  • Digital
    edited by Kent R. Olson ; associate editors, Ilene B. Anderson ... [et al.] ; [by the faculty, staff, and Associates of the California Poison Control System].
    AccessMedicine2012
    Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
  • Digital
    edited by Kent R. Olson ; associate editors Ilene B. Anderson, Neal L. Benowitz, Paul D. Blanc, Richard F. Clark, Thomas E. Kearney, Susan Y. Jim-Katz, and Alan H.B. Wu.
    AccessMedicine2018
    "Designed for speed of use during toxicologic emergencies, this instant-answer guide delivers critical information on the effective diagnosis and treatment of drug-related emergencies and chemical exposures. Enhanced by detailed tables and charts, extensive cross-referencing, and a comprehensive index, the Seventh Edition has been thoroughly updated to reflect newly released drugs and the latest information on existing drugs. Poisoning & Drug Overdose is divided into four sections: Section 1 leads you through initial emergency management, including treatment of coma, hypotension, and other common complications; physical and laboratory diagnosis; and methods of decontamination and enhanced eliminations of poisons. Section II provides detailed information on hundreds of common drugs and poisons. Section III describes the use and side effects of more than 80 antidotes and therapeutic drugs Section IV covers the medical management of chemical spills and occupational chemical exposures, and includes a table of more than 500 industrial chemicals. Poisoning & Drug Overdose, Seventh Edition should be within reach of every medical toxicologist, emergency physician, and poison control staff member"--Publisher's description.
  • Print
    Zbinden, Gerhard.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Mathieu Vinken, Vera Rogiers.
    Springer Protocols2015
    Isolation and culture of mouse hepatocytes -- Cryopreservation of hepatocytes -- Culture conditions promoting proliferation and cell cycle synchronization -- Immortalized human hepatic cell lines for In vitro testing and research purposes -- Culture and functional characterization of human hepatoma hepG2s -- Establishment and characterization of an in vitro model of Fas-mediated hepatocyte cell death -- Serum-free directed differentiation of human embryonic stem cells to hepatocytes -- Human skin-derived precursor Cells: isolation, expansion, and hepatic differentiation -- Generation of hepatocytes from pluripotent stem cells for drug screening and developmental modeling -- Differentiation-promoting medium additives for hepatocyte -- Cultivation and cryopreservation -- Coculture and long-term maintenance of hepatocytes -- Primary hepatocytes in sandwich culture -- Establishing liver bioreactors for In Vitro Research -- Epigenetic modifications as antidedifferentiation strategy for primary hepatocytes in culture -- Transfection of Primary Hepatocytes with Liver-enriched transcription factors using adenoviral vectors -- Transcriptomics of hepatocytes treated with Toxicants for Investigating Molecular mechanisms underlying hepatotoxicity -- Global microRNA analysis in primary hepatocyte Cultures -- Mass Spectrometry-Based proteomics for telative protein quantification and biomarker Identification in primary human Hepatocytes -- Targeted metabolomics for homocysteine-related metabolites in primary hepatocytes -- Measurement of cytochrome P450 Enzyme Induction and Inhibition in human hepatoma cells -- Analysis of sinusoidal drug uptake transporter activities in Primary Human Hepatocytes -- Measurement of albumin secretion as functionality test in primary hepatocyte cultures -- Measurembent of Blood Coagulation Factor Synthesis in cultures of human hepatocytes -- Functionality testing of primary hepatocytes in Culture by Measuring Urea Synthesis -- Assay of Bile acid conjugation and excretion in human hepatocytes -- General cytotoxicity assessment by Means of the MTT assay -- Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures -- Critical factors in the Assessment of cholestatic liver injury In vitro -- In vitro cell culture models of hepatic steatosis -- Assessment of liver fibrotic Insults In Vitro.
  • Digital
    edited by David G. Allen and Michael D. Waters.
    R Soc Chem2013
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • Digital/Print
    Digital : WHO2011
    Print2011
    The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
  • Digital
    edited by Ramesh Gupta.
    ScienceDirect2011
    Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2017
  • Digital
    Nicholas J. Mantis, editor.
    Springer2012
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • Digital
    Jose Russo, Irma H. Russo.
    Springer2013
    This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Digital
    edited by Heide Schatten, Abraham Eisenstark.
    Springer Protocols2015
    Luminex® multiplex bead suspension arrays for the detection and serotyping of Salmonella spp / Sherry A. Dunbar [and 4 others] -- Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle / Dora Kaloyanova [and 3 others] -- Determination of antimicrobial resistance in Salmonella spp / Belgode N. Harish and Godfred A. Menezes -- Red-mediated recombineering of Salmonella enterica genomes / Frederik Czarniak and Michael Hensel -- A method to introduce an internal tag sequence into a Salmonella chromosomal gene / Weidong Zhao and Stéphane Méresse -- Generation and use of site-directed chromosomal cyaA' translational fusions in Salmonella enterica / Francisco Ramos-Morales [and 3 others] -- Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot / Edith Porter [and 3 others] -- Detecting non-typhoid Salmonella in humans by enzyme-linked immunosorbent assays (ELISAs) : practical and epidemiological aspects / Katrin G. Kuhn [and 3 others] -- Study of the Stn protein in Salmonella; a regulator of membrane composition and integrity / Masayuki Nakano [and 4 others] -- Development of a bacterial nanoparticle vaccine / Carlos Gamazo [and 4 others] -- Direct attachment of nanparticle cargo to Salmonella typhimurium membranes designed for combination bacteriotherapy against tumors / Robert Kazmierczak [and 3 others] -- Applications of microscopy in Salmonella research / Layla M. Malt [and 3 others] -- Live cell imaging of intracellular Salmonella enterica / Alexander Kehl and Michael Hensel -- In vitro modeling of gallbladder-associated Salmonella spp. colonization / Geoffrey Gonzalez-Escobedo and John S. Gunn -- Salmonella phages and prophages : genomics, taxonomy, and applied aspects / Andrea I. Moreno Switt [and 6 others].
  • Digital
    Richard J. Lewis, Sr.
    Wiley2012
    "Includes comprehensive hazard information on the substances encountered in the workplace. The objective of the work is to promote safety by providing the most up-to-date hazard information available"--Provided by publisher. "Since its inception in the early 1950's, this book has become the "bible" for those who need to evaluate the hazard of substances used in commerce. The book contains extensive data on approximately 28,000 substances. It is designed to fill the information needs of professionals who must work with and evaluate the hazards of chemicals"--Provided by publisher.
  • Digital/Print
    first draft prepared by Mr. Philip Copestake.
    Digital : WHO2010
    Print2010
  • Digital
    Mario A. Dicato, editor.
    Springer2013
    Drug Interactions and Pharmacogenetics -- Breast Cancer -- Lung Cancer -- Gastrointestinal Cancer: Selection of Clinically Relevant Drug-Induced Toxicities Encountered in Gastrointestinal Cancer Treatment -- Gynecologic Cancer -- Genitourinary Cancer -- Central Nervous System -- Bone Marrow Toxicity: Red Blood Cells -- Bone Marrow Toxicity: White Blood Cells -- Dermatologic Side Effects of Systemic Anticancer Therapy -- Myeloid Malignancies -- Lymphoma -- Multiple Myeloma -- Preservation of Fertility in the Cancer Patient -- Cardiotoxicity -- Toxicity of Bone-Targeted Agents in Malignancy -- State of the Art of Antiemetic Therapy -- Side Effects of Nociceptive Cancer Pain Treatments in Adults -- Totally Implanted Access Ports: Indications and Prevention of Complications.
  • Digital
    Richard P. Pohanish, editor.
    Knovel2002
  • Digital/Print
    Digital : WHO2008
    Print2008
  • Digital
    Erich Gulbins, Irina Petrache, editors.
    Springer2013
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Digital
    Erich Gulbins, Irina Petrache, editors.
    Springer2013
    Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • Digital/Print
    first draft prepared by Peter Watts and Paul Howe.
    Digital : WHO2010
    Print2010
  • Digital
    edited by Leslie W. Tari.
    Springer Protocols2012
    The utility of structural biology in drug discovery / Leslie W. Tari -- Genetic construct design and recombinant protein expression for structural biology / Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson -- Purification of proteins for crystallographic applications / Daniel C. Bensen -- Protein crystallization for structure-based drug design / Isaac D. Hoffman -- X-ray sources and high-throughput data collection methods / Gyorgy Snell -- The use of molecular graphics in structure-based drug design / Paul Emsley and Judit É. Debreczeni -- Crystallographic fragment screening / John Badger -- The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase / Mark L. Cunningham -- Leveraging structural information for the discovery of new drugs : computational methods / Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone -- Chemical informatics : using molecular shape descriptors in structure-based drug design / Andy Jennings -- Accounting for solvent in structure-based drug design / Leslie W. Tari -- Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein / Andrew D. Ferguson -- Application of SBDD to the discovery of new antibacterial drugs / John Finn -- Leveraging SBDD in protein therapeutic development : antibody engineering / Gary L. Gilliland [and others] -- A medicinal chemistry perspective on structure-based drug design and development / Shawn P. Maddaford.
  • Digital
    Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan.
    Springer2013
    Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • Digital
    edited by Paul C. Barrow.
    Springer Protocols2013
    ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.
  • Digital
    ATSDR2010
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Print
    Irving Sunshine, section editor.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Philip Wexler.
    ScienceDirect2017
    Toxicology in the Middle Ages and Renaissance provides an authoritative and fascinating exploration into the use of toxins and poisons in the Middle Ages and Renaissance. Part of the History of Toxicology and Environmental Health series, this volume is a follow-up, chronologically, to the first two volumes which explored toxicology in antiquity. The book approximately covers the 1100s through the 1600s, delving into different aspects of toxicology, such as the contributions of scientific scholars of the time, sensational poisoners and poisoning cases, as well as myths. Historical figures, such as the Borgias and Catherine de Medici are discussed. Toxicologists, students, medical researchers, and those interested in the history of science will find insightful and relevant material in this volume. Provides the historical background for understanding modern toxicologyIllustrates the ways previous civilizations learned to distinguish safe from hazardous substances, how to avoid them, and how to use them against enemies. Explores the way famous historical figures used toxins.
  • Digital
    [edited by] Ken Donaldson... [and others].
    Knovel2012
    "The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors"-- Provided by publisher.
  • Digital
    R. Manjunatha Kini, Kenneth J. Clemetso, Francis S. Markland, Mary Ann McLane, Takashi Morita, editors.
    Springer2010
    "Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents."
  • Digital
    edited by Jerome O. Nriagu and Eric P. Skaar.
    ProQuest Ebook Central2015
    Introduction / Jerome O. Nriagu and Eric P. Skaar -- Is metal uptake related to ecological niche in the vertebrate host? / Joseph Lemire, Trevor F. Moraes, Vahis Fa Andisi, and Anthony B. Schryvers -- Competition for metals among microbes and their host / Michaell A. Bachman and Jeffrey N. Weiser -- The fate of intracellular metal ions in microbes / Slade A. Loutet, Anson C.K. Chan, Marek J. Kobylarz, Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye, Angel L. Arrieta, and Michael E.P. Murphy -- Common mechanisms of bacterial metal homeostasis / James A. Imlay -- Intervention strategies for metal deficiency and overload / Fudi Wang and Lihong Zhang -- Trace metals in host-microbe interactions : the microbe perspective / Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E.P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, and Jeffrey N. Weiser -- Metal homeostasis during development, maturation, and aging : impact on infectious diseases / Inga Wessels -- Impact of metals on immune response and tolerance, and modulation of metal metabolism during infection / Günter Weiss -- Metal-based antiparasitic therapeutics / Maribel Navarro and Gonzalo Visbal -- Impact of lifestyle on metal exposure, homeostasis, and associated diseases / George V. Dedoussis -- Obesity, trace metals, and infection / Jerome O. Nriagu -- Metals in host-microbe interaction : the host perspective / Dieter Rehder, Robert E. Black, Julia Bornhorst, Rodney R. Dietert, Victor J. DiRita, Maribel Navarro, Robert D. Perry, Lothar Rink, Eric P. Skaar, Miguel C.P. Soares, Dennis J. Thiele, Fudi Wang, Günter Weiss, and Inga Wessels -- Selenium and mercury : their interactions and roles in living organisms / Tamara Garcia-Barrera -- New technologies using trace metals of concern / Jozef M. Pacyna, Kyrre Sundseth, and Elisabeth G. Pacyna -- The promise of nanometals : reducing infection and increasing biocompatibility / Mian Wang, Wenwen Liu, and Thomas J. Webster -- Metals in the environment as risk factors for infectious diseases : gaps and opportunities / M. Leigh Ackland, Julia Bornhorst, George V. Dedoussis, Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna, and John M. Pettifor -- Emerging strategies in metalloproteomics / Peter-Leon Hagedoorn -- Measuring metals in complex biological systems / Andreas Matusch, Ana-Maria Oros-Peusquens, and J. Sabine Becker -- Methods and technologies for studying metals in biological systems / Wolfgang Maret, Joseph A. Caruso, Christopher H. Contag, David P. Giedroc, Peter-Leon Hagedoorn, Andreas Matusch, Eric P. Skaar, and Richard B. Thompson.
  • Digital
    edited by Michael D. Waters, Claude L. Hughes.
    Wiley2018
    Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline. What Stressors Cause Cancer and When? / Claude L Hughes, Michael D Waters -- What Mutagenic Events Contribute to Human Cancer and Genetic Disease? / Michael D Waters -- Developmental Origins of Cancer / Suryanarayana V Vulimiri, John M Rogers -- The Mechanistic Basis of Cancer Prevention / Bernard W Stewart -- Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and Progression Over Time. Diet Factors in Cancer Risk / Lynnette R Ferguson -- Voluntary Exposures: Natural Herbals, Supplements, and Substances of Abuse - What Evidence Distinguishes Therapeutic from Adverse Responses? / Eli P Crapper, Kylie Wasser, Katelyn J Foster, Warren G Foster -- Voluntary Exposures: Pharmaceutical Chemicals in Prescription and Over-the-Counter Drugs - Passing the Testing Gauntlet / Ronald D Snyder -- Children's and Adult Involuntary and Occupational Exposures and Cancer / Annamaria Colacci, Monica Vaccari -- Gene-Environment Interactions. Ethnicity, Geographic Location, and Cancer / Fengyu Zhang -- Dietary/Supplemental Interventions and Personal Dietary Preferences for Cancer: Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Sandeep Kaur, Elaine Trujillo, Harold Seifried -- Social Determinants of Health and the Environmental Exposures: A Promising Partnership / Lauren Fordyce, David Berrigan, Shobha Srinivasan -- Categorical and Pleiotropic Nonmutagenic Modes of Action of Toxicants: Causality. Bisphenol A and Nongenotoxic Drivers of Cancer / Natalie R Gassman, Samuel H Wilson -- Toxicoepigenetics and Effects on Life Course Disease Susceptibility / Luke Montrose, Jaclyn M Goodrich, Dana C Dolinoy -- Tumor-Promoting/Associated Inflammation and the Microenvironment: A State of the Science and New Horizons / William H Bisson, Amedeo Amedei, Lorenzo Memeo, Stefano Forte, Dean W Felsher -- Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology / R Brooks Robey -- Biomarkers for Detecting Premalignant Effects and Responses to Protective Therapies during Critical Windows of Development. Circulating Molecular and Cellular Biomarkers in Cancer / Ilaria Chiodi, A Ivana Scovassi, Chiara Mondello -- Global Profiling Platforms and Data Integration to Inform Systems Biology and Translational Toxicology / Barbara A Wetmore -- Developing a Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Rebecca Johnson, David Kerr -- Ethical Considerations in Developing Strategies for Protecting Fetuses, Neonates, Children, and Adolescents from Exposures to Hazardous Environmental Agents / David B Resnik, Melissa J Mills.
  • Digital/Print
    Chantra Eskes, Maurice Whelan, editors.
    Digital : Springer2016
    Print2016
    Introduction / Chantra Eskes, Maurice Whelan -- Validation in support of internationally harmonised OECD test guidelines for assessing the safety of chemicals / Anne Gourmelon, Nathalie Delrue -- Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals / Sonja Beken, Peter Kasper, Jan-Willem van der Laan -- Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools / Claudius Griesinger, Bertrand Desprez, Sandra Coecke, Warren Casey, Valérie Zuang -- Practical aspects of designing and conducting validation studies involving multi-study trials / Sandra Coecke [and others] -- Validation of computational methods / Grace Patlewicz, Andrew P. Worth, Nicholas Ball -- Implementation of new test methods into practical testing / Rodger D. Curren, Albrecht Poth, Hans A. Raabe -- Pathway based toxicology and fit-for-purpose assays / Rebecca A. Clewell [and others] -- Evidence-based toxicology / Sebastian Hoffmann, Thomas Hartung, Martin Stephens -- Validation of transcriptomics-based in vitro methods / Raffaella Corvi, Mireia Vilardell, Jiri Aubrecht, Aldert Piersma -- Ensuring the quality of stem cell-derived in vitro models for toxicity testing -- Glyn N. Stacey, Sandra Coecke, Anna-Bal Price, Lyn Healy, Paul Jennings, Anja Wilmes& -- Validation of bioreactor and human-on-a-chip devices for chemical safety assessment -- Sofia P. Rebelo [and others] -- Integrated approaches to testing and assessment / Andrew P. Worth, Grace Patlewicz -- International harmonization and cooperation in the validation of alternative methods / João Barroso [and others] -- Evolving the principles and practice of validation for new alternative approaches to toxicity testing / Maurice Whelan, Chantra Eskes.
  • Digital
    Scott A. Weinstein, David A. Warrell, Julian White and Daniel E. Keyler.
    ScienceDirect2011
    This book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity. Fills a gap in the toxinological, medical and herpetological literature by providing a comprehensive review of this entire assemblage of snakes, with particular attention given to their capacity, real or rumored, to cause harm to humans A patient-centered, evidence-based approach is applied to analyzing documented case reports of bites inflicted by approximately 100 species. Clinical management of medically significant bites from non-front-fanged colubroids is methodically reviewed, and specific recommendations are provided.
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2018
  • Digital
    European Monitoring Centre for Drugs and Drug Addiction.
    Wastewater analysis is a rapidly developing scientific discipline with the potential for monitoring real-time population-level trends in illicit drug use. Originally used in the 1990s to monitor the environmental impact of liquid household waste, the method has since been used to estimate illicit drug consumption in different cities (Daughton, 2001; Zuccato et al., 2008; van Nuijs et al., 2011). It involves sampling a source of wastewater, such as a sewage influent to a wastewater treatment plant. This allows scientists to estimate the quantity of drugs consumed in a community by measuring the levels of illicit drugs and their metabolites excreted in urine (Zuccato et al., 2008).
  • Digital/Print
    World Health Organization.
    Digital : WHO2010
    Print2010
    "The purpose of this publication is to provide its users with guidance to identify, acquire and use the information needed to assess chemical hazards, exposures and the corresponding health risks in their given health risk assessment contexts at local and/or national levels. The toolkit provides information for conducting a human health risk assessment, identifies information that must be gathered to complete an assessment and provides electronic links to international resources from which the user can obtain information and methods essential for conducting the human health risk assessment"--Publisher's description.
  • Digital
    edited by Anna Członkowska and Michael L. Schilsky.
    ScienceDirect2017
    History of Wilson disease: a personal account / J M. Walshe -- Epidemiology and introduction to the clinical presentation of Wilson disease / Christine Lo and Oliver Bandmann -- The genetics of Wilson disease / Sihoun Hahn -- Genetic and environmental modifiers of Wilson disease / Valentina Medici and Karl Heinz Weiss -- Pathogenesis of Wilson disease / Petr Dusek, Radan Bruha and Ivo Florin Scheiber -- Animal models of Wilson disease / Dominik Huster and Valentina Medici -- Wilson disease, liver pathology / Maciej Pronicki -- Wilson disease, brain pathology / France Woimant, Aurelia Poujois and Jacqueline Mikol -- Hepatic features of Wilson disease / Michael L. Schilsky, Aftab Ala and Salih Boga -- Wilson disease: neurologic features / Anna Czlonkowska, Tomasz Litwin and Grzegorz Chabik -- Cognitive and psychiatric symptoms in Wilson disease / Paula C. Zimbrean and Joanna Seniow -- Wilson's disease in children / Eve A. Roberts and Piotr Socha -- Other organ involvement and clinical aspects of Wilson disease / Karolina Dzieżyc, Tomasz Litwin and Anna Czlonkowska -- Diagnosis of Wilson disease / Peter Ferenci -- Wilson disease - currently used anti-copper therapy / Anna Czlonkowska and Tomasz Litwin -- Liver transplantation for Wilson disease / Michael L. Schilsky -- Wilson disease - symptomatic liver therapy / Wolfgang Stremmel and Karl Heinz Weiss -- Symptomatic treatment of neurologic symptoms in Wilson disease / Tomasz Litwin, Petr Dusek and Anna Czlonkowska -- Novel perspectives on Wilson disease treatment / Christian Rupp, Wolfgang Stremmel and Karl Heinz Weiss -- Patient support groups in the management of Wilson disease / Michael L. Schilsky and Mary L. Graper.
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