Lane Medical Library

Books by Subject

Toxicology

  • Digital
    edited by Jerry Zweigenbaum.
    Springer Protocols2011
    European union regulations / Peter Furst -- China's food safety regulation and mass spectrometry / Xiaogang Chu [and others] -- United States and Japanese food regulations / Jerry Zweigenbaum -- QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods / Steven J. Lehotay -- Automated solid phase extraction / Norbert Helle, Meike Baden, and Kaj Petersen -- Multiresidue pesticide analysis by capillary gas chromatography-mass spectrometry / Jon W. Wong [and others] -- Targeted pesticide residue analysis using triple quad LC-MS/MS / Lutz Alder -- LC/TOF-MS analysis of pesticides in fruits and vegetables : the emerging role of accurate mass in the unambiguous identification of pesticides in food / Imma Ferrer, E. Michael Thurman, and Jerry Zweigenbaum -- Hormone analysis in food products / Marco H. Blokland and Saskia S. Sterk -- Analysis of multiple mycotoxins in food / Jana Hajslova, Milena Zachariasova, and Tomas Cajka -- Multi mycotoxin analysis in food products using immunoaffinity extraction / Masahiko Takino, Hiroki Tanaka, and Toshitsugu Tanaka -- Multiresidue analysis of antibiotics in food of animal origin using liquid chromatography-mass spectrometry / Katerina Mastovska -- LC-MS/MS methods for the determination of specific antibiotics residues in food matrices / Gui-Liang Chen and Yan-Yan Fang -- Identification of unknown migrants from food contact materials / Malcolm Driffield [and others] -- Halogenated persistent organic pollutants and polycyclic aromatic hydrocarbons in food / Tomas Cajka and Jana Hajslova.
  • Digital
    edited by Pavel Anzenbacher and Ulrich M. Zanger.
    Wiley2012
    Biochemistry and molecular genetics of drug metabolism -- Drug-metabolizing enzymes: an overview -- Cytochromes P450 -- UDP-glucuronosyltransferases -- Sulfotransferases -- Glutathione s-transferases -- Hydrolytic enzymes -- Transporting systems -- Transcriptional regulation of human drug-metabolizing cytochrome P450 enzymes -- Importance of pharmacogenomics -- Metabolism of drugs -- Introduction to drug metabolism -- Central nervous system drugs -- Cardiovascular drugs -- Anticancer drugs -- Antimicrobial agents -- Drugs against acute and chronic pain -- Drugs of abuse (including designer drugs) -- Nicotine metabolism and its implications -- Metabolism of alcohol and its consequences -- Metabolism of natural compounds -- Introduction and overview -- Food components and supplements -- Metabolism of unnatural xenobiotics -- Environmental pollutants -- Environmental estrogens -- Biotransformation of insecticides.
  • Digital
    Sandra Ceccatelli, Michael Aschner, editors.
    Springer2012
    Annotation Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHgs accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This bookwill provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
  • Digital
    editor-in-chief: Jeffrey K. Aronson.
    ClinicalKey2017
  • Digital/Print
    Lang Tran, Miguel A. Bañares, Robert Rallo, editors.
    Digital : Springer2017
    Print2017
    In today's nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.
  • Digital
    edited by Andreas Luch.
    Springer2009
  • Digital
    edited by Andreas Luch.
    Springer2010
  • Digital
    edited by Andreas Luch.
    Springer2012
    Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Digital
    edited by Phouthone Keohavong, Stephen G. Grant.
    Springer Protocols2014
    Array-Based Immunoassays with Rolling-Circle Amplification Detection -- Analysis of Protein Changes Using Two-Dimensional Difference Gel Electrophoresis -- Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage -- Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System -- Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques -- Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR) -- Strategies for Measurement of Biotransformation Enzyme Gene Expression -- Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism Screening -- TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material -- 32P-Postlabeling Analysis of DNA Adducts -- Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot -- DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry -- Analysis of DNA Strand Cleavage at Abasic Sites -- Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes Without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization Probes -- Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk -- Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair -- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice -- The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay -- Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and Mice -- Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes. (Continued) -- Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model Systems -- The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic Mutation -- Molecular Analysis of Mutations in the Human HPRT Gene -- Simultaneous Quantification of t(14; 18) and HPRT Exon 2/3 Deletions in Human Lymphocytes -- Mutation Screening of the TP53 Gene by Temporal Temperature Gel Electrophoresis (TTGE) -- Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples -- ACB-PCR Quantification of Somatic Oncomutation -- Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection: Limitations and Solutions -- Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions -- Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells -- The Sister Chromatid Exchange (SCE) Assay -- The Gene Cluster Instability (GCI) Assay for Recombination -- Measuring Recombination Proficiency in Mouse Embryonic Stem Cells -- Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery -- Unscheduled DNA Synthesis: The Clinical and Functional Assay for Global Genomic DNA Nucleotide Excision Repair -- Analysis of Actively Transcribed DNA Repair Using a Transfection-Based System -- An Immunoassay for Measuring Repair of UV Photoproducts -- Analysis of Double-Strand Break Repair by Nonhomologous DNA End Joining in Cell-Free Extracts from Mammalian Cells -- Bioenergetic Analysis of Intact Mammalian Cells Using the Seahorse XF24 Extracellular Flux Analyzer and a Luciferase ATP Assay -- Quantification of Selective Phosphatidylserine Oxidation During Apoptosis -- Quantitative Method of Measuring Phosphatidylserine Externalization During Apoptosis Using Electron Paramagnetic Resonance (EPR) Spectroscopy and Annexin-Conjugated Iron -- Detection of Programmed Cell Death in Cells Exposed to Genotoxic Agents Using a Caspase Activation Assay.
  • Digital
    Marie-Odile Parat, editor.
    Springer2013
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Digital
    edited by Ashutosh Kumar, Vasily N. Dobrovolsky, Alok Dhawan, Rishi Shanker.
    ScienceDirect2018
  • Digital
    edited by Joshua Reineke.
    Springer Protocols2012
    Historical overview of nanotechnology and nanotoxicology -- Characterization of nanomaterials for toxicological studies -- Methods for understanding the interaction between nanoparticles and cells -- Single-cell gel electrophoresis (comet) assay in nano-genotoxicology -- Single-cell nanotoxicity assays of superparamagnetic iron oxide nanoparticles -- Western blot analysis -- Application of reverse transcription-PCR and real-time PCR in nanotoxicity research -- Deriving TC(50) values of nanoparticles from electrochemical monitoring of lactate dehydrogenase activity indirectly -- Enzyme-linked immunosorbent assay of IL-8 production in response to silver nanoparticles -- Metabolomics techniques in nanotoxicology studies -- Nanoparticle uptake measured by flow cytometry -- Determining biological activity of nanoparticles as measured by flow cytometry -- Whole cell impedance biosensoring devices -- Free energy calculation of permeant-membrane interactions using molecular dynamics simulations -- Screening of fullerene toxicity by hemolysis assay -- Assessment of in vitro skin irritation potential of nanoparticles: RHE model -- In vivo methods of nanotoxicology -- The luminescent bacteria test to determine the acute toxicity of nanoparticle suspensions -- The primacy of physicochemical characterization of nanomaterials for reliable toxicity assessment: A review of the zebrafish nanotoxicology model -- Application of embryonic and adult zebrafish for nanotoxicity assessment -- Applications of subsurface microscopy -- Application of ICP-MS for the study of disposition and toxicity of metal-based nanomaterials -- Quantitative nanoparticle organ disposition by gel permeation chromatography -- Physiologically based pharmacokinetic modeling for nanoparticle toxicity study -- Biophysical methods for assessing plant responses to nanoparticle exposure -- In vivo nanotoxicity assays in plant models.
  • Digital
    edited by Satyajit D. Sarker, Lutfun Nahar.
    Springer Protocols2012
    An introduction to natural products isolation -- Initial and bulk extraction of natural products isolation -- Supercritical fluid extraction in natural products analyses -- Accelerated solvent extraction for natural products isolation -- Microwave-assisted extraction in natural products isolation -- An introduction to planar chromatography and its application to natural products isolation -- Isolation of natural products by low-pressure column chromatography -- Isolation of natural products by ion-exchange methods -- Separation of natural products by countercurrent chromatography -- Isolation of natural products by preparative high performance liquid chromatography (prep-HPLC) -- Isolation of natural products by preparative gas chromatography -- Hyphenated techniques and their applications in natural products analysis -- Extraction of plant secondary metabolites -- Isolation of marine natural products -- Isolation of microbial natural products -- Extraction and isolation of saponins -- Extraction and isolation of phenolic compounds -- Scaling-up of natural products isolation -- Follow-up of natural products isolation -- Natural products isolation in modern drug discovery programs.
  • Digital
    Jiří Bajgar.
    ScienceDirect2012
    Chemical weapons -- Chemical warfare agents -- Organophosphates and nerve agents -- Toxicodynamics -- Antidotal treatment -- Prophylaxis.
  • Digital
    Daniel Thomas Ginat, Juan E. Small, Pamela Whitney Schaefer, editors.
    Springer2015
    This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.
  • Digital
    Richard M. Kostrzewa, Trevor Archer, editors.
    Springer2016
    From the contents: Preface -- ADHD Modeling by Perinatal Insult in Animals -- Perinatal Insults to Model Human Neuro-Psychiatric Disorders -- Selective Life-long Destructive of Brain Monoaminergic Nerves -- NGF in Perinatal Development -- Life-long Susceptibility Consequent to Perinatal Substances of Abuse -- Schizotypic Effects of Perinatal Insults.
  • Digital
    Soodabeh Saeidnia.
    Springer2015
    This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also℗ℓincludes discussion of℗ℓnew areas℗ℓsuch as℗ℓbiotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have℗ℓbeen the subject of discussion℗ℓin this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
  • Digital/Print
    edited by Michael Balls, Robert D. Combes, Nirmala Bhogal.
    Digital : Springer2012
    Print2012
    Current developments in cell culture technology / Glyn Stacey -- Embryonic stem cells in safety pharmacology and toxicology / Tina C. Stummann and Susanne Bremer -- Trends in cell culture technology / Uwe Marx -- Tissue engineering in the development of replacement technologies / Kevin M. Shakesheff and Felicity R.A.J. Rose -- Toxicity testing of nanomaterials / Amanda M. Schrand ... [et al.] -- Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment / John C. Lipscomb ... [et al.] -- In silico methods for toxicity prediction / Robert D. Combes -- Luminescent quantum dots for molecular toxicology / Shivang R. Dave -- Engineering quasi-vivo, in-vitro organ models / Tommaso Sbrana and Arti Ahluwalia -- ECVAM and new technologies for toxicity testing / Susanne Bremer ... [et al.] -- Medium to high throughput screening : microfabrication and chip-based technology / Yuan Wen, Xudong Zhang, and Shang-Tian Yang -- The use of genomics in model in vitro systems / Daniel A. Casciano -- The use of integrated and intelligent testing strategies in the prediction of toxic hazard and in risk assessment / Michael Balls, Robert D. Combes, and Nirmala Bhogal.
  • Digital
    Emilija Veljkovic, Wenhao Xia, Blaine Phillips, Ee Tsin Wong, Jenny Ho, Alberto Oviedo, Julia Hoeng, Manuel Peitsch.
    ScienceDirect2018
    Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Tourette's syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.
  • Digital/Print
    Peter M. Eller, editor.
    Digital : Google Books1984-
  • Digital
  • Digital
    Mark A. Geyer, Gerhard Gross, editors.
    Springer2012
    This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • Digital
    Rakesh Kumar, editor.
    Springer2014
    Preface -- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression -- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer -- RUNX2 Transcriptional Regulation in Development and Disease -- Epigenetic Mechanisms of Cancer Metastasis -- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications -- Nuclear Factors Linking Cancer and Inflammation -- Regulation of the Jak/STATs Pathways by Histone Deacetylases -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers -- Nucleolar Signaling Determines Cell Fate The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment -- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology -- Domain Specific Targeting of Cancer -- The Potential of Targeting Splicing for Cancer Therapy -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies -- Histone Demethylases in Prostate Cancer -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer -- Index.
  • Print
    Status: Not Checked OutLane Catalog Record
  • Digital
    Klaus Aktories, Joachim H.C. Orth, Ben Adler, editors.
    Springer2012
    Pasteurella multocida: Diseases and Pathogenesis / I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler -- Pathogenomics of Pasteurella multocida / J. D. Boyce, T. Seemann, B. Adler and M. Harper -- The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide / Marina Harper, John D. Boyce and Ben Adler -- Pasteurella multocida and Immune Cells / Katharina F. Kubatzky -- Molecular Biology of Pasteurella multocida Toxin / Joachim H. C. Orth and Klaus Aktories -- Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects / Brenda A. Wilson and Mengfei Ho -- Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin / Yasuhiko Horiguchi -- The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer / Alistair Lax.
  • Digital
    Stephen T. Sonis, Dorothy M. Keefe, editors.
    Springer2013
  • Digital
    edited by Elizabeth McInnes.
    Wiley2017
    An Introduction to Pathology Techniques / Elizabeth McInnes -- Recording Pathology Data / Cheryl L Scudamore -- General Pathology and the Terminology of Basic Pathology / Elizabeth McInnes -- Common Spontaneous and Background Lesions in Laboratory Animals / Elizabeth McInnes -- Target Organ Pathology / Elizabeth McInnes -- Clinical Pathology / Barbara Beust -- Adversity: A Pathologist's Perspective / Bhanu Singh -- Limitations of Pathology and Animal Models / Natasha Neef.
  • Digital
    Gowraganahalli Jagadeesh, Pitchai Balakumar, Khin Maung-U, editors.
    Springer2015
  • Digital
    Robert L. Harris, editor ; contributors, H.E. Ayer ... [et al.].
    Knovel2000
  • Print
    George D. Clayton and Florence E. Clayton, editors ; contributors, M. C. Battigelli ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1. General principles -- v. 2A, Toxicology ; v. 3. Theory and rationale of industrial hygiene practice.
  • Print
    George D. Clayton, Florence E. Clayton, editors ; contributors, R.E. Allan ... [et al.].
    Status: Not Checked OutLane Catalog Record
    v. 1, pt. A-B. General principles -- v. 2, pt. A-F. Toxicology.
  • Digital
    editor, Ernest Hodgson.
    ScienceDirect2012
    Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
  • Digital
    edited by Qing Yan, PharmTao, Santa Clara, CA, USA.
    Springer Protocols2014
    From pharmacogenomics and systems biology to personalized care : a framework of systems and dynamical medicine / Qing Yan -- Translational bioinformatics approaches for systems and dynamical medicine / Qing Yan -- Whole blood transcriptomic analysis to identify clinical biomarkers of drug response / Grant P. Parnell and David R. Booth -- Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies / Raffaele Palmirotta [and six others] -- Approach to clinical and genetic characterization of statin-induced myopathy / QiPing Feng -- Pharmacogenomics of membrane transporters : a review of current approaches / Tristan M. Sissung [and four others] -- G protein-coupled receptor accessory proteins and signaling : pharmacogenomic insights / Miles D. Thompson [and three others] -- G protein-coupled receptor mutations and human genetic disease / Miles D. Thompson [and four others] -- Pharmacogenetics of the G protein-coupled receptors / Miles D. Thompson [and six others] -- Pharmacogenomics of heart failure / Anastasios Lymperopoulos and Faren French -- Pharmacogenomics in the development and characterization of atheroprotective drugs / Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou -- Management of side effects in the personalized medicine era : chemotherapy-induced peripheral neuropathy / Paolo Alberti and G. Cavaletti -- Pharmacogenomics of Alzheimer's disease : novel therapeutic strategies for drug development / Ramón Cacabelos [and four others] -- Pharmacogenetics of antipsychotic treatment in schizophrenia / Jennie G. Pouget and Daniel J. Müller / Pharmacogenetics of addiction therapy / David A. Nielsen [and three others] -- Pharmacogenetics in rheumatoid arthritis / Deepali Sen, Jisna R. Paul, and Prabha Ranganathan -- Pharmacogenetics of osteoporotic fractures / José A. Riancho and Flor M. Pérez-Campo -- Pharmacogenomics and pharmacoepigenomics in pediatric medicine / Barkur S. Shastry -- Pharmacogenomics in children / Michael Rieder.
  • Digital
    Luisa Rocha, Esper A. Cavalheiro, editors.
    Springer2013
    Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
  • Print
    Deborah Blum.
    The untold story of how poison rocked Jazz Age New York City. A pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Chief medical examiner Charles Norris and toxicologist Alexander Gettler investigate a family mysteriously stricken bald, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler create revolutionary experiments to tease out even the wiliest compounds from human tissue. From the vantage of their laboratory it also becomes clear that murderers aren't the only toxic threat--modern life has created a kind of poison playground, and danger lurks around every corner.
  • Digital
    edited by Kent R. Olson ; associate editors, Ilene B. Anderson ... [et al.] ; [by the faculty, staff, and Associates of the California Poison Control System].
    AccessMedicine2012
    Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
  • Digital
    edited by Kent R. Olson ; associate editors Ilene B. Anderson, Neal L. Benowitz, Paul D. Blanc, Richard F. Clark, Thomas E. Kearney, Susan Y. Jim-Katz, and Alan H.B. Wu.
    AccessMedicine2018
    "Designed for speed of use during toxicologic emergencies, this instant-answer guide delivers critical information on the effective diagnosis and treatment of drug-related emergencies and chemical exposures. Enhanced by detailed tables and charts, extensive cross-referencing, and a comprehensive index, the Seventh Edition has been thoroughly updated to reflect newly released drugs and the latest information on existing drugs. Poisoning & Drug Overdose is divided into four sections: Section 1 leads you through initial emergency management, including treatment of coma, hypotension, and other common complications; physical and laboratory diagnosis; and methods of decontamination and enhanced eliminations of poisons. Section II provides detailed information on hundreds of common drugs and poisons. Section III describes the use and side effects of more than 80 antidotes and therapeutic drugs Section IV covers the medical management of chemical spills and occupational chemical exposures, and includes a table of more than 500 industrial chemicals. Poisoning & Drug Overdose, Seventh Edition should be within reach of every medical toxicologist, emergency physician, and poison control staff member"--Publisher's description.
  • Print
    Zbinden, Gerhard.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Mathieu Vinken, Vera Rogiers.
    Springer Protocols2015
    Isolation and culture of mouse hepatocytes -- Cryopreservation of hepatocytes -- Culture conditions promoting proliferation and cell cycle synchronization -- Immortalized human hepatic cell lines for In vitro testing and research purposes -- Culture and functional characterization of human hepatoma hepG2s -- Establishment and characterization of an in vitro model of Fas-mediated hepatocyte cell death -- Serum-free directed differentiation of human embryonic stem cells to hepatocytes -- Human skin-derived precursor Cells: isolation, expansion, and hepatic differentiation -- Generation of hepatocytes from pluripotent stem cells for drug screening and developmental modeling -- Differentiation-promoting medium additives for hepatocyte -- Cultivation and cryopreservation -- Coculture and long-term maintenance of hepatocytes -- Primary hepatocytes in sandwich culture -- Establishing liver bioreactors for In Vitro Research -- Epigenetic modifications as antidedifferentiation strategy for primary hepatocytes in culture -- Transfection of Primary Hepatocytes with Liver-enriched transcription factors using adenoviral vectors -- Transcriptomics of hepatocytes treated with Toxicants for Investigating Molecular mechanisms underlying hepatotoxicity -- Global microRNA analysis in primary hepatocyte Cultures -- Mass Spectrometry-Based proteomics for telative protein quantification and biomarker Identification in primary human Hepatocytes -- Targeted metabolomics for homocysteine-related metabolites in primary hepatocytes -- Measurement of cytochrome P450 Enzyme Induction and Inhibition in human hepatoma cells -- Analysis of sinusoidal drug uptake transporter activities in Primary Human Hepatocytes -- Measurement of albumin secretion as functionality test in primary hepatocyte cultures -- Measurembent of Blood Coagulation Factor Synthesis in cultures of human hepatocytes -- Functionality testing of primary hepatocytes in Culture by Measuring Urea Synthesis -- Assay of Bile acid conjugation and excretion in human hepatocytes -- General cytotoxicity assessment by Means of the MTT assay -- Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures -- Critical factors in the Assessment of cholestatic liver injury In vitro -- In vitro cell culture models of hepatic steatosis -- Assessment of liver fibrotic Insults In Vitro.
  • Digital
    edited by David G. Allen and Michael D. Waters.
    R Soc Chem2013
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • Digital/Print
    Digital : WHO2011
    Print2011
    The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
  • Digital
    edited by Ramesh Gupta.
    ScienceDirect2011
    Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2017
  • Digital
    Nicholas J. Mantis, editor.
    Springer2012
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • Digital
    Jose Russo, Irma H. Russo.
    Springer2013
    This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Digital
    edited by Heide Schatten, Abraham Eisenstark.
    Springer Protocols2015
    Luminex® multiplex bead suspension arrays for the detection and serotyping of Salmonella spp / Sherry A. Dunbar [and 4 others] -- Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle / Dora Kaloyanova [and 3 others] -- Determination of antimicrobial resistance in Salmonella spp / Belgode N. Harish and Godfred A. Menezes -- Red-mediated recombineering of Salmonella enterica genomes / Frederik Czarniak and Michael Hensel -- A method to introduce an internal tag sequence into a Salmonella chromosomal gene / Weidong Zhao and Stéphane Méresse -- Generation and use of site-directed chromosomal cyaA' translational fusions in Salmonella enterica / Francisco Ramos-Morales [and 3 others] -- Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot / Edith Porter [and 3 others] -- Detecting non-typhoid Salmonella in humans by enzyme-linked immunosorbent assays (ELISAs) : practical and epidemiological aspects / Katrin G. Kuhn [and 3 others] -- Study of the Stn protein in Salmonella; a regulator of membrane composition and integrity / Masayuki Nakano [and 4 others] -- Development of a bacterial nanoparticle vaccine / Carlos Gamazo [and 4 others] -- Direct attachment of nanparticle cargo to Salmonella typhimurium membranes designed for combination bacteriotherapy against tumors / Robert Kazmierczak [and 3 others] -- Applications of microscopy in Salmonella research / Layla M. Malt [and 3 others] -- Live cell imaging of intracellular Salmonella enterica / Alexander Kehl and Michael Hensel -- In vitro modeling of gallbladder-associated Salmonella spp. colonization / Geoffrey Gonzalez-Escobedo and John S. Gunn -- Salmonella phages and prophages : genomics, taxonomy, and applied aspects / Andrea I. Moreno Switt [and 6 others].
  • Digital
    Richard J. Lewis, Sr.
    Wiley2012
    "Includes comprehensive hazard information on the substances encountered in the workplace. The objective of the work is to promote safety by providing the most up-to-date hazard information available"--Provided by publisher. "Since its inception in the early 1950's, this book has become the "bible" for those who need to evaluate the hazard of substances used in commerce. The book contains extensive data on approximately 28,000 substances. It is designed to fill the information needs of professionals who must work with and evaluate the hazards of chemicals"--Provided by publisher.
  • Digital/Print
    first draft prepared by Mr. Philip Copestake.
    Digital : WHO2010
    Print2010
  • Digital
    Mario A. Dicato, editor.
    Springer2013
    Drug Interactions and Pharmacogenetics -- Breast Cancer -- Lung Cancer -- Gastrointestinal Cancer: Selection of Clinically Relevant Drug-Induced Toxicities Encountered in Gastrointestinal Cancer Treatment -- Gynecologic Cancer -- Genitourinary Cancer -- Central Nervous System -- Bone Marrow Toxicity: Red Blood Cells -- Bone Marrow Toxicity: White Blood Cells -- Dermatologic Side Effects of Systemic Anticancer Therapy -- Myeloid Malignancies -- Lymphoma -- Multiple Myeloma -- Preservation of Fertility in the Cancer Patient -- Cardiotoxicity -- Toxicity of Bone-Targeted Agents in Malignancy -- State of the Art of Antiemetic Therapy -- Side Effects of Nociceptive Cancer Pain Treatments in Adults -- Totally Implanted Access Ports: Indications and Prevention of Complications.
  • Digital
    Richard P. Pohanish, editor.
    Knovel2002
  • Digital/Print
    Digital : WHO2008
    Print2008
  • Digital
    Erich Gulbins, Irina Petrache, editors.
    Springer2013
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Digital
    Erich Gulbins, Irina Petrache, editors.
    Springer2013
    Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • Digital/Print
    first draft prepared by Peter Watts and Paul Howe.
    Digital : WHO2010
    Print2010
  • Digital
    edited by Leslie W. Tari.
    Springer Protocols2012
    The utility of structural biology in drug discovery / Leslie W. Tari -- Genetic construct design and recombinant protein expression for structural biology / Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson -- Purification of proteins for crystallographic applications / Daniel C. Bensen -- Protein crystallization for structure-based drug design / Isaac D. Hoffman -- X-ray sources and high-throughput data collection methods / Gyorgy Snell -- The use of molecular graphics in structure-based drug design / Paul Emsley and Judit É. Debreczeni -- Crystallographic fragment screening / John Badger -- The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase / Mark L. Cunningham -- Leveraging structural information for the discovery of new drugs : computational methods / Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone -- Chemical informatics : using molecular shape descriptors in structure-based drug design / Andy Jennings -- Accounting for solvent in structure-based drug design / Leslie W. Tari -- Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein / Andrew D. Ferguson -- Application of SBDD to the discovery of new antibacterial drugs / John Finn -- Leveraging SBDD in protein therapeutic development : antibody engineering / Gary L. Gilliland [and others] -- A medicinal chemistry perspective on structure-based drug design and development / Shawn P. Maddaford.
  • Digital
    Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan.
    Springer2013
    Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • Digital
    edited by Paul C. Barrow.
    Springer Protocols2013
    ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.
  • Digital
    ATSDR2010
  • Digital/Print
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Digital : ATSDR2008
    Print2008
  • Print
    Irving Sunshine, section editor.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Philip Wexler.
    ScienceDirect2017
    Toxicology in the Middle Ages and Renaissance provides an authoritative and fascinating exploration into the use of toxins and poisons in the Middle Ages and Renaissance. Part of the History of Toxicology and Environmental Health series, this volume is a follow-up, chronologically, to the first two volumes which explored toxicology in antiquity. The book approximately covers the 1100s through the 1600s, delving into different aspects of toxicology, such as the contributions of scientific scholars of the time, sensational poisoners and poisoning cases, as well as myths. Historical figures, such as the Borgias and Catherine de Medici are discussed. Toxicologists, students, medical researchers, and those interested in the history of science will find insightful and relevant material in this volume. Provides the historical background for understanding modern toxicologyIllustrates the ways previous civilizations learned to distinguish safe from hazardous substances, how to avoid them, and how to use them against enemies. Explores the way famous historical figures used toxins.
  • Digital
    [edited by] Ken Donaldson... [and others].
    Knovel2012
    "The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors"-- Provided by publisher.
  • Digital
    R. Manjunatha Kini, Kenneth J. Clemetso, Francis S. Markland, Mary Ann McLane, Takashi Morita, editors.
    Springer2010
    "Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents."
  • Digital
    edited by Jerome O. Nriagu and Eric P. Skaar.
    ProQuest Ebook Central2015
    Introduction / Jerome O. Nriagu and Eric P. Skaar -- Is metal uptake related to ecological niche in the vertebrate host? / Joseph Lemire, Trevor F. Moraes, Vahis Fa Andisi, and Anthony B. Schryvers -- Competition for metals among microbes and their host / Michaell A. Bachman and Jeffrey N. Weiser -- The fate of intracellular metal ions in microbes / Slade A. Loutet, Anson C.K. Chan, Marek J. Kobylarz, Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye, Angel L. Arrieta, and Michael E.P. Murphy -- Common mechanisms of bacterial metal homeostasis / James A. Imlay -- Intervention strategies for metal deficiency and overload / Fudi Wang and Lihong Zhang -- Trace metals in host-microbe interactions : the microbe perspective / Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E.P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, and Jeffrey N. Weiser -- Metal homeostasis during development, maturation, and aging : impact on infectious diseases / Inga Wessels -- Impact of metals on immune response and tolerance, and modulation of metal metabolism during infection / Günter Weiss -- Metal-based antiparasitic therapeutics / Maribel Navarro and Gonzalo Visbal -- Impact of lifestyle on metal exposure, homeostasis, and associated diseases / George V. Dedoussis -- Obesity, trace metals, and infection / Jerome O. Nriagu -- Metals in host-microbe interaction : the host perspective / Dieter Rehder, Robert E. Black, Julia Bornhorst, Rodney R. Dietert, Victor J. DiRita, Maribel Navarro, Robert D. Perry, Lothar Rink, Eric P. Skaar, Miguel C.P. Soares, Dennis J. Thiele, Fudi Wang, Günter Weiss, and Inga Wessels -- Selenium and mercury : their interactions and roles in living organisms / Tamara Garcia-Barrera -- New technologies using trace metals of concern / Jozef M. Pacyna, Kyrre Sundseth, and Elisabeth G. Pacyna -- The promise of nanometals : reducing infection and increasing biocompatibility / Mian Wang, Wenwen Liu, and Thomas J. Webster -- Metals in the environment as risk factors for infectious diseases : gaps and opportunities / M. Leigh Ackland, Julia Bornhorst, George V. Dedoussis, Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna, and John M. Pettifor -- Emerging strategies in metalloproteomics / Peter-Leon Hagedoorn -- Measuring metals in complex biological systems / Andreas Matusch, Ana-Maria Oros-Peusquens, and J. Sabine Becker -- Methods and technologies for studying metals in biological systems / Wolfgang Maret, Joseph A. Caruso, Christopher H. Contag, David P. Giedroc, Peter-Leon Hagedoorn, Andreas Matusch, Eric P. Skaar, and Richard B. Thompson.
  • Digital
    edited by Michael D. Waters, Claude L. Hughes.
    Wiley2018
    Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline. What Stressors Cause Cancer and When? / Claude L Hughes, Michael D Waters -- What Mutagenic Events Contribute to Human Cancer and Genetic Disease? / Michael D Waters -- Developmental Origins of Cancer / Suryanarayana V Vulimiri, John M Rogers -- The Mechanistic Basis of Cancer Prevention / Bernard W Stewart -- Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and Progression Over Time. Diet Factors in Cancer Risk / Lynnette R Ferguson -- Voluntary Exposures: Natural Herbals, Supplements, and Substances of Abuse - What Evidence Distinguishes Therapeutic from Adverse Responses? / Eli P Crapper, Kylie Wasser, Katelyn J Foster, Warren G Foster -- Voluntary Exposures: Pharmaceutical Chemicals in Prescription and Over-the-Counter Drugs - Passing the Testing Gauntlet / Ronald D Snyder -- Children's and Adult Involuntary and Occupational Exposures and Cancer / Annamaria Colacci, Monica Vaccari -- Gene-Environment Interactions. Ethnicity, Geographic Location, and Cancer / Fengyu Zhang -- Dietary/Supplemental Interventions and Personal Dietary Preferences for Cancer: Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Sandeep Kaur, Elaine Trujillo, Harold Seifried -- Social Determinants of Health and the Environmental Exposures: A Promising Partnership / Lauren Fordyce, David Berrigan, Shobha Srinivasan -- Categorical and Pleiotropic Nonmutagenic Modes of Action of Toxicants: Causality. Bisphenol A and Nongenotoxic Drivers of Cancer / Natalie R Gassman, Samuel H Wilson -- Toxicoepigenetics and Effects on Life Course Disease Susceptibility / Luke Montrose, Jaclyn M Goodrich, Dana C Dolinoy -- Tumor-Promoting/Associated Inflammation and the Microenvironment: A State of the Science and New Horizons / William H Bisson, Amedeo Amedei, Lorenzo Memeo, Stefano Forte, Dean W Felsher -- Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology / R Brooks Robey -- Biomarkers for Detecting Premalignant Effects and Responses to Protective Therapies during Critical Windows of Development. Circulating Molecular and Cellular Biomarkers in Cancer / Ilaria Chiodi, A Ivana Scovassi, Chiara Mondello -- Global Profiling Platforms and Data Integration to Inform Systems Biology and Translational Toxicology / Barbara A Wetmore -- Developing a Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Rebecca Johnson, David Kerr -- Ethical Considerations in Developing Strategies for Protecting Fetuses, Neonates, Children, and Adolescents from Exposures to Hazardous Environmental Agents / David B Resnik, Melissa J Mills.
  • Digital/Print
    Chantra Eskes, Maurice Whelan, editors.
    Digital : Springer2016
    Print2016
    Introduction / Chantra Eskes, Maurice Whelan -- Validation in support of internationally harmonised OECD test guidelines for assessing the safety of chemicals / Anne Gourmelon, Nathalie Delrue -- Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals / Sonja Beken, Peter Kasper, Jan-Willem van der Laan -- Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools / Claudius Griesinger, Bertrand Desprez, Sandra Coecke, Warren Casey, Valérie Zuang -- Practical aspects of designing and conducting validation studies involving multi-study trials / Sandra Coecke [and others] -- Validation of computational methods / Grace Patlewicz, Andrew P. Worth, Nicholas Ball -- Implementation of new test methods into practical testing / Rodger D. Curren, Albrecht Poth, Hans A. Raabe -- Pathway based toxicology and fit-for-purpose assays / Rebecca A. Clewell [and others] -- Evidence-based toxicology / Sebastian Hoffmann, Thomas Hartung, Martin Stephens -- Validation of transcriptomics-based in vitro methods / Raffaella Corvi, Mireia Vilardell, Jiri Aubrecht, Aldert Piersma -- Ensuring the quality of stem cell-derived in vitro models for toxicity testing -- Glyn N. Stacey, Sandra Coecke, Anna-Bal Price, Lyn Healy, Paul Jennings, Anja Wilmes& -- Validation of bioreactor and human-on-a-chip devices for chemical safety assessment -- Sofia P. Rebelo [and others] -- Integrated approaches to testing and assessment / Andrew P. Worth, Grace Patlewicz -- International harmonization and cooperation in the validation of alternative methods / João Barroso [and others] -- Evolving the principles and practice of validation for new alternative approaches to toxicity testing / Maurice Whelan, Chantra Eskes.
  • Digital
    Scott A. Weinstein, David A. Warrell, Julian White and Daniel E. Keyler.
    ScienceDirect2011
    This book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity. Fills a gap in the toxinological, medical and herpetological literature by providing a comprehensive review of this entire assemblage of snakes, with particular attention given to their capacity, real or rumored, to cause harm to humans A patient-centered, evidence-based approach is applied to analyzing documented case reports of bites inflicted by approximately 100 species. Clinical management of medically significant bites from non-front-fanged colubroids is methodically reviewed, and specific recommendations are provided.
  • Digital
    edited by Ramesh C. Gupta.
    ScienceDirect2018
  • Digital
    European Monitoring Centre for Drugs and Drug Addiction.
    Wastewater analysis is a rapidly developing scientific discipline with the potential for monitoring real-time population-level trends in illicit drug use. Originally used in the 1990s to monitor the environmental impact of liquid household waste, the method has since been used to estimate illicit drug consumption in different cities (Daughton, 2001; Zuccato et al., 2008; van Nuijs et al., 2011). It involves sampling a source of wastewater, such as a sewage influent to a wastewater treatment plant. This allows scientists to estimate the quantity of drugs consumed in a community by measuring the levels of illicit drugs and their metabolites excreted in urine (Zuccato et al., 2008).
  • Digital/Print
    World Health Organization.
    Digital : WHO2010
    Print2010
    "The purpose of this publication is to provide its users with guidance to identify, acquire and use the information needed to assess chemical hazards, exposures and the corresponding health risks in their given health risk assessment contexts at local and/or national levels. The toolkit provides information for conducting a human health risk assessment, identifies information that must be gathered to complete an assessment and provides electronic links to international resources from which the user can obtain information and methods essential for conducting the human health risk assessment"--Publisher's description.
  • Digital
    edited by Anna Członkowska and Michael L. Schilsky.
    ScienceDirect2017
    History of Wilson disease: a personal account / J M. Walshe -- Epidemiology and introduction to the clinical presentation of Wilson disease / Christine Lo and Oliver Bandmann -- The genetics of Wilson disease / Sihoun Hahn -- Genetic and environmental modifiers of Wilson disease / Valentina Medici and Karl Heinz Weiss -- Pathogenesis of Wilson disease / Petr Dusek, Radan Bruha and Ivo Florin Scheiber -- Animal models of Wilson disease / Dominik Huster and Valentina Medici -- Wilson disease, liver pathology / Maciej Pronicki -- Wilson disease, brain pathology / France Woimant, Aurelia Poujois and Jacqueline Mikol -- Hepatic features of Wilson disease / Michael L. Schilsky, Aftab Ala and Salih Boga -- Wilson disease: neurologic features / Anna Czlonkowska, Tomasz Litwin and Grzegorz Chabik -- Cognitive and psychiatric symptoms in Wilson disease / Paula C. Zimbrean and Joanna Seniow -- Wilson's disease in children / Eve A. Roberts and Piotr Socha -- Other organ involvement and clinical aspects of Wilson disease / Karolina Dzieżyc, Tomasz Litwin and Anna Czlonkowska -- Diagnosis of Wilson disease / Peter Ferenci -- Wilson disease - currently used anti-copper therapy / Anna Czlonkowska and Tomasz Litwin -- Liver transplantation for Wilson disease / Michael L. Schilsky -- Wilson disease - symptomatic liver therapy / Wolfgang Stremmel and Karl Heinz Weiss -- Symptomatic treatment of neurologic symptoms in Wilson disease / Tomasz Litwin, Petr Dusek and Anna Czlonkowska -- Novel perspectives on Wilson disease treatment / Christian Rupp, Wolfgang Stremmel and Karl Heinz Weiss -- Patient support groups in the management of Wilson disease / Michael L. Schilsky and Mary L. Graper.

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Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

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Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.