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ToxicologyAccess restricted to Stanford unless otherwise noted

  • Fulltext ClinicalKey
  • The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
  • In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog). A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists. . New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures.
  • Ibuprofen 2012, Springer
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • This book serves as a hands-on guide to various poison treatments and offers supplemental public health information. Each two-page unit features concise text on the left complemented by full-color illustrations on the opposing page. The expert author distinguishes harmful toxic substances and catalogues their specific effects on the human body, plants, animals, and the surrounding environment. The handbook also addresses other topics, including biological warfare, modern toxicological methods, and threshold values. Features include: succinct, user-friendly organization so readers can navigate the content with ease; over 600 detailed images and diagrams arranged on 150 full-color plates illustrate exposures and toxicological effects on humans, plants, and animals; well-researched, objective risk analysis on toxic exposures accompanied by relevant images; extensive glossary of key toxicological terms that provide readers with the accurate information they need to avoid dangerous confusion.
  • Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • v. 1. Principles and methods of immunotoxicology.
  • In vitro neurotoxicology 2004, Springer Protocols
  • Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
  • pt.1. IPCS/OECD key generic terms used in chemical hazard/risk assessment -- pt.2. IPCS glossary of key exposure assessment terminology
  • Jet fuel toxicology 2011, CRCnetBASE
    Air Force-related jet fuel toxicology research (1991-2010) / Walter J. Kozumbo -- Jet fuel composition / Tim Edwards -- The toxicity and underlying mechanism of jet propulsion fuel-8 on the respiratory system / Simon S. Wong and Mark L. Witten -- Neurotoxicological and neurobehavioral effects from exposure to jet fuels / Glenn D. Ritchie -- Differential protein expression following JP-8 jet fuel exposure / Frank A. Witzmann and Mark L. Witten -- Immune modulation by dermal exposure to jet fuel / Gerardo Ramos and Stephen E. Ullrich -- Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components / James E. Riviere, Alfred O. Inman, and Nancy Monteiro-Riviere -- Methods of assessing skin irritation and sensitization of jet fuels / R. Jayachandra Babu, Ram Patlolla, and Mandip Singh -- Understanding systemic and local toxicity of JP-8 after cutaneous exposures / James N. McDougal, James V. Rogers, and Richard Simman -- The effects of aerosolized JP-8 jet fuel exposure on the immune system: a review / David T. Harris -- The involvement of poly(ADP-ribosyl)ation in defense against JP-8 jet fuel and other chemical toxicants / Luis A. Espinoza ... [et al.] -- Evaluation of methods used to generate and characterize jet fuel vapor and aerosol for inhalation toxicology studies / Raphaël T. Tremblay, Sheppard A. Martin, and Jeffrey W. Fisher -- Genetic damage in the blood and bone marrow of mice treated with JP-8 jet fuel / Vijayalaxmi -- Computational analyses of JP-8 fuel droplet and vapor depositions in human upper airway models / Clement Kleinstreuer and Zhe Zhang -- Human exposure to Jet Propellant-8 / Raymond H. Tu and Terence H. Risby.
  • "This book bridges the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments. 10 chapters describe major areas of progress in the laboratory and clinic. In the first section, the aspects of cellular organelles are discussed. In the second, the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches are covered. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally the clinical implications for the understanding of acute and chronic renal toxicity are studied"--Provided by publisher.
  • v. 2 Springer
  • Evaluting efficacy of barrier creams: in vitro and in vivo models -- Light-induced dermal toxicity: effects on cellular and molecular levels -- Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products -- Exogenous ochronosis: update -- Diagnostic patch test: science and art -- Irritant and allergic contact dermatitis treatment -- Factors affecting children's susceptibility to chemicals -- Utilization of irritation data in local lymph node assay -- Air bag injuries -- Cigarette smoking and skin -- Chemical analysis of tattoo pigments cleaved by laser light -- Dermatotoxicology of specialized epithelia: adapting cutaneous test methods to assess topical effects on vulva -- Anti-irritants: myth or reality? overview -- Evaluating mechanical and chemical irritation using the behind-the-knee tests: review -- Need for more sensitive tools as we reach limits of our ability to detect differences in skin effects from mild products -- Drug patch testing in systemic cutaneous drug allergy -- Hormesis and dermatology -- Diagnosis of drug hypersensitivity in vitro -- Immunologic patterns in allergic and irritant contact dermatitis: similarities -- Water decontamination of chemical skin and eye splashes: critical review -- Chemical substances and contact allergy: 244 substances ranked according to allergenic potency -- Use of modified forearm controlled application test to evaluate skin irritation of lotion formulations -- Hair in toxicology -- Popliteal lymph node assay -- Pigmentation changes resulting from arsenic exposure -- Textiles and human skin, microclimate, cutaneous reactions: overview -- In vivo human transfer of topical bioactive drugs among individuals: estradiol -- Is there evidence that geraniol causes allergic contact dermatitis? -- Operational definition of a causative contact allergen-study with six fragrance allergens -- Sodium lauryl sulfate-induced irritation in human faces: regional- and age-related differences -- Classification of irritant contact dermatitis -- In vitro skin irritation testing on SkinEthic[tm]-reconstituted human epidermis: reproducibility for fifty chemicals tested with two protocols -- Identifying source of textile-dye allergic contact dermatitis: guidelines -- Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate -- Is contact allergy lifelong in humans? an overview of patch-test follow-ups -- Irritants in combination with synergistic or additive effect on skin response overview of tandem irritation studies -- Allergic contact dermatitis from iodine preparations: a conundrum? -- Human skin buffering capacity: oveview.Pesticide percutaneous absorption and decontamination -- Tape stripping method versus stratum corneum -- Parameters influencing stratum corneum removal by tape stripping -- Quantification of stratum corneum removed by tape stripping -- Isolated perfused porcine skin flap -- Physiologically based pharmacokinetic modeling -- Methods for in vitro skin metabolism studies -- Predicitive toxicology methods for transdermal delivery systems -- Animal, human, and in vitro test methods for predicting skin irritation -- Kawaki method for testing irritation -- Analysis of structural change in intercellular lipids of humam stratum corneum induced by surfactants: electron paramagnetic resonance (EPR) study -- Water and saline compresses in treatment of irritant contact dermatitis: literature review -- Reaction of skin blood vessels to successive insults on normal and irritated human skin -- Specificity of retinoid-induced irritation and its role in clinical efficacy -- Topical corticosteroids in the treatment of irritant dermatitis: do they work? -- Tests for sensitive skin -- Test methods for allergic contact dermatitis in animals -- Test methods for allergic contact dermatitis in humans -- Allergic contact dermatitis: elicitation thresholds of potent allergens in humans -- Allergic contact dermatitis to topical anesthetics: a cross-sensitization phenomenon -- Contact urticaria and anaphylaxis to chlorhexidine: overview -- Immunoadjuvants in prospective testing for contact allergens -- Local lymph node assay -- Iontophresis in humans: regional variations in skin barrier function and cutaneous irritation -- Contact urticaria and contact urticaria syndrome (immediate contact reactions) -- In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials -- Photoirritation (phototoxicity) testing in humans -- Measuring and quantifying ultraviolet radiation exposures -- Determination of subclinical changes of barrier function -- Assessing validity of alternative methods for toxicity testing: role and activities of ECVAM -- Animal models of contact urticaria -- Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria -- Cosmetic reactions -- Decreasing allergic contact dermatitis frequency through dermatotoxicologic- and epidemiologic-based intervention? -- Cutaneous corticosteroid-induced glaucoma --Pharmacogenetics and dermatology -- Ethnic differences in skin properties: objective data -- Occlusion and barrier function -- Anatomical factors affecting barrier function -- Percutaneous penetration enhancers: overview -- Percutaneous absorption of complex chemical mixtures -- Percutaneous absorption: short-term exposure, lag time, multiple exposures, model variations, and absorption from clothing -- Percutaneous absorption: 7 roles of lipids -- Chemical partitioning into powdered human stratum corneum: a useful in vitro model for studying interactions of chemicals and human skin -- Sensitive skin -- Transdermal drug delivery system: an overview -- Transdermal drug delivery system: an overview -- Iontophoresis: from historical perspective to its place in modern medicine -- Irritant dermatitis: clinical heterogeneity and contributing factors -- Systemic contact dermatitis -- Allergic contact dermatitis -- Mechanisms in irritant and allergic contact dermatitis -- Occupational allergic contact dermatitis: rational work-up -- Systemic toxicity -- Concepts in molecular dermatotoxicology -- Molecular basis of allergic contact dermatitis -- Photoirritation (phototoxicity, phototoxic dermatitis) -- Permeability of skin to metal compounds, with focus on nickel and copper -- Chemically induced scleroderma -- Chemical agents that cause depigmentation -- Carcinogenesis: current trends in skin cancer research -- Retinoids and mechanisms of their toxicity -- Mechanisms in cutaneous drug hypersensitivity reactions -- Drug-induced ocular phototoxicity -- Water: is it an irritant? -- Sodium lauryl sulfate -- Factors influencing applied amounts of topical preparations -- Barrier creams -- OECD guidelines for testing of chemicals -- Methods for in vitro percutaneous absorption -- Percutaneous absorption of hazardous substances from soil and water --
  • "Arsenite contamination of drinking water is a major cause of chronic illness and mortality in many countries, but until recently little was known of the processes determining its movement and concentration. Bacterial oxidation of arsenite was first described in 1918 and thought to be a means of detoxification. It was not until 2000 that the first autotrophic arsenite-oxidising bacterium was isolated and shown to gain energy from arsenite oxidation. Since then a wide range of such bacteria has been isolated and the literature on the topic has grown rapidly. This book reviews the new understanding of the diversity and abundance of such organisms, their role in arsenic cycling in the environment and their possible relations with arsenic-dependent diseases in humans"-- Provided by publisher.
  • Molecular toxicology 2004, CRCnetBASE
  • Molecular toxicology protocols 2004, Springer Protocols
    Analysis of K-RAS and P53 mutations in sputum samples / Weimin Gao and Phouthone Keohavong -- Allele-specific competitive blocker-PCR detection of rare base substitution / Barbara L. Parsons, Page B. McKinzie, and Robert H. Heflich -- Gel-based nonradioactive single-strand conformational polymorphism and mutation detection: limitations and solutions / Vibhuti Gupta ... [et al.] -- Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions / Toshinari Minamoto -- Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR / Michael J. Villalobos, Christopher J. Betti, and Andrew T.M. Vaughan -- Microsatellite instability: an indirect assay to detect defects in the cellular mismatch repair machinery / Anjana Saha, Narendra K. Bairwa, and Ramesh Bamezai -- Unscheduled DNA synthesis: a functional assay for global genomic nucleotide excision repair / Crystal M. Kelly and Jean J. Latimer -- Analysis of DNA repair using transfection-based host cell reactivation / Jennifer M. Johnson and Jean J. Latimer -- An immunoassay for measuring repair of ultraviolet photoproducts / Shirley McCready -- Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells / Petra Pfeiffer ... [et al.] --The comet-FISH technique: a tool for detection of specific DNA damage and repair / Alexander Rapp, Michael Hausmann, and Karl Otto Greulich -- DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis / Nina Joshi and Stephen G. Grant -- Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes / Vasily N. Dobrovolsky, Joseph G. Shaddock, and Robert H. Heflich -- Quantifying in vivo somatic mutations using transgenic mouse model systems / Roy R. Swiger -- Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants / Sai-Mei Hou -- Molecular analysis of mutations in the human HPRT gene / Phouthone Keohavong, Liqiang Xi, and Stephen G. Grant -- Simultaneous quantification of t(14;18) and HPRT exon 2/3 deletions in human lymphocytes / James C. Fuscoe -- The GPA in vivo somatic mutation assay / Stephen G. Grant -- Flow cytometric measurement of mutant T cells with altered expression of TCR: detecting somatic mutations in humans and mice / Seishi Kyoizumi, Yoichiro Kusunoki, and Tomonori Hayashi -- Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis / Therese Sørlie ... [et al.] --³²P-postlabeling analysis of DNA adducts / David H. Phillips, Alan Hewer, and Volker M. Arlt -- Modification of the ³²P-postlabeling method to detect a single adduct as a single spot / Masako Ochiai, Takashi Sugimura, and Minako Nagao -- DNA isolation and sample preparation for quantification of adduct levels by accelerator mass spectrometry / Karen H. Dingley ... [et al.] -- Fluoroimaging-based immunoassay of DNA photoproducts in ultraviolet-B-irradiated tadpoles / Iovanna Pandelova, Stephen R. Hewitt, and John B. Hays -- Analysis of DNA strand cleavage at abasic sites / Walter A. Deutsch and Vijay Hegde -- Premature chromosome condensation in human resting peripheral blood lymphocytes for chromosome aberration analysis using specific whole-chromosome DNA hybridization probes / Pataje G.S. Prasanna and William F. Blakely -- Mutagen-induced chromatid breakage as a marker of cancer risk / Xifeng Wu, Yun-Ling Zheng, and T.C. Hsu -- Flow cytometric analysis of micronuclei in erythrocytes / Jan Grawé -- The comet assay: a sensitive genotoxicity test for the detection of DNA damage / Günter Speit and Andreas Hartmann -- Computerized image analysis software for the comet assay / R.C. Chaubey --Measuring recombination proficiency in mouse embryonic stem cells / Andrew J. Pierce and Maria Jasin -- Strategies for measurement of biotransformation enzyme gene expression / Marjorie Romkes and Shama C. Buch -- Genotyping technologies: application to biotransformation enzyme genetic polymorphism screening / Marjorie Romkes and Shama C. Buch -- TaqMan® fluorogenic detection system to analyze gene transcription in autopsy material / Kaori Shintani-Ishida, Bao-Li Zhu, and Hitoshi Maeda -- Development of quantitative reverse transcriptase PCR assays for measuring gene expression / Tony E. Godfrey and Lori A. Kelly -- Quantification of selective phosphatidylserine oxidation during apoptosis / James P. Fabisiak ... [et al.] -- Quantitative method of measuring of phosphatidylserine externalization during apoptosis using electron paramagnetic resonance spectroscopy and annexin-conjugated iron / James P. Fabisiak, Grigory G. Borisenko, and Valerian E. Kagan -- Detection of programmed cell death in cells exposed to genotoxic agents using a caspase activation assay / Michael E. Gehring and Patrick P. Koty.
  • Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Morphine and metastasis 2013, Springer
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Mycotoxins in food 2004, CRCnetBASE
  • Chemical weapons -- Chemical warfare agents -- Organophosphates and nerve agents -- Toxicodynamics -- Antidotal treatment -- Prophylaxis.
  • This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • "Today, we are exposed to an ever-growing number of chemicals in the environment and there is an increasing awareness of the effects of these chemicals on the ovaries. As such, the potential for xenobiotic-induced infertility needs to be better understood. Additionally, menopause-associated disorders are of growing health concern in view of the fact that by the year 2025, 19.5% of the population of the U.S. will be menopause-aged women. Exploring research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles, this book is an essential resource for researchers in academia, regulatory agencies, and industry"--Provided by publisher.
  • Particle toxicology 2007, CRCnetBASE
    An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly Bérubé -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody --Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderón-Garcidueñas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schülte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm.
  • Pasteurella multocida 2012, Springer
    Pasteurella multocida: Diseases and Pathogenesis /I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler --Pathogenomics of Pasteurella multocida /J. D. Boyce, T. Seemann, B. Adler and M. Harper --The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide /Marina Harper, John D. Boyce and Ben Adler --Pasteurella multocida and Immune Cells /Katharina F. Kubatzky --Molecular Biology of Pasteurella multocida Toxin /Joachim H. C. Orth and Klaus Aktories --Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects /Brenda A. Wilson and Mengfei Ho --Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin /Yasuhiko Horiguchi --The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer /Alistair Lax.
  • Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
  • Pesticide protocols 2005, Springer Protocols
  • Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
  • Print Material
  • Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
  • Print Material
  • Introduction to postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Specimen selection, collection, preservation, and security / Bradford R. Hepler and Daniel S. Isenschmid -- Common methods in postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Strategies for postmortem toxicology investigation / edited and revised by Henrik Druid -- Quality assurance in postmortem toxicology / Wilmo Andollo -- Interpretation of postmortem drug levels / Graham R. Jones.
  • Predictive toxicology 2005, CRCnetBASE
  • Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
  • Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • Ricin and shiga toxins 2012, Springer
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • Riot control agents 2004, CRCnetBASE
  • This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Salmonella 2007, Springer Protocols
    Quantitative, multiplexed detection of salmonella and other pathogens by Luminex xMAP suspension array / Sherry A. Dunbar and James W. Jacobson -- Detection of salmonella by bacteriophage felix 01 / Jonathan C. Kuhn -- Physical mapping of salmonella genomes / Shu-Lin Liu -- Cloth-based hybridization array system for the identification of antibiotic resistance genes in salmonella / Burton W. Blais and Martine Gauthier -- Genome-based identification and molecular analysee of pathogenicity islands and genomic islands in Salmonella enterica / Michael Hensel -- Determination of the gene content of salmonella genomes by microarray analysis / Steffen Porwollik and Michael McClelland -- In vivo excision, cloning, and broad-host-range transfer of large bacterial DNA segments using VEX-capture / James W. Wilson and Cheryl A. Nickerson -- Amplified fragment length polymorphism analysis of Salmonella enterica / Ruiting Lan and Peter R. Reeves -- Salmonella phages and prophages : genomics and practical aspects / Andrew M. Kropinski ... [et al.] -- Salmonella typhimurium phage typing for pathogens / Wolfgang Rabsch -- Salmonella phages examined in the electron microscope / Hans-W. Ackermann -- Applications of cell imaging in salmonella research / Charlotte A. Perrett and Mark A. Jepson -- Analysis of kinesin accumulation on salmonella-containing vacuoles / Audrey Dumont ... [et al.] -- Magnesium, manganese, and divalent cation transport assays in intact cells / Michael E. Maguire -- Methods in cell-to-cell signaling in salmonella / Brian M. M. Ahmer ... [et al.] -- Development of salmonella strains as cancer therapy agents and testing in tumor cell lines / Abraham Eisenstark ... [et al.] -- Further resources for molecular protocols in salmonella research / Abraham Eisenstark and Kelly K. Edwards.
  • "Includes comprehensive hazard information on the substances encountered in the workplace. The objective of the work is to promote safety by providing the most up-to-date hazard information available"--Provided by publisher."Since its inception in the early 1950's, this book has become the "bible" for those who need to evaluate the hazard of substances used in commerce. The book contains extensive data on approximately 28,000 substances. It is designed to fill the information needs of professionals who must work with and evaluate the hazards of chemicals"--Provided by publisher.
  • Sphingolipids 2013, Springer
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Sphingolipids in disease 2013, Springer
    Sphingolipids in Cancer.Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance /Shanmugam Panneer Selvam, Besim Ogretmen --Using ASMase Knockout Mice to Model Human Diseases /Guoqiang Hua, Richard Kolesnick --New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer /Susan Pyne, Nigel J. Pyne --Sphingolipids and Response to Chemotherapy /Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard --Lung Cancer and Lung Injury: The Dual Role of Ceramide /Tzipora Goldkorn, Samuel Chung, Simone Filosto --Sphingolipids' Role in Radiotherapy for Prostate Cancer /Carla Hajj, Adriana Haimovitz-Friedman --Sphingolipids in Cardio-Reno-vascular Diseases.Sphingolipid Metabolism and Atherosclerosis /Xian-Cheng Jiang, Jing Liu --Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) /Bodo Levkau --Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease /Pin-Lan Li, Yang Zhang --Sphingolipids in Inflammation, Infection and Lung Diseases.Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity /Taimur Abbasi, Joe G. N. Garcia --Sphingolipids in Acute Lung Injury /Stefan Uhlig, Yang Yang --The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases /Irina Petrache, Daniela N. Petrusca --Ceramide in Cystic Fibrosis /Heike Grassmé, Joachim Riethmüller, Erich Gulbins --Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway /K. Alexa Orr Gandy, Lina M. Obeid --Bacterial Infections and Ceramide /Heike Grassmé, Katrin Anne Becker --Viral Infections and Sphingolipids /Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies --Ceramide in Plasma Membrane Repair /Annette Draeger, Eduard B. Babiychuk --Sphingolipids and Inflammatory Diseases of the Skin /Burkhard Kleuser, Lukasz Japtok --Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease /S. B. Russo, J. S. Ross, L. A. Cowart --Sphingolipids in Neuro-psychiatry and Muscle Diseases.Neuronal Forms of Gaucher Disease /Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation /Laura Davies, Klaus Fassbender, Silke Walter --Sphingolipids in Psychiatric Disorders and Pain Syndromes /C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber --Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology /Paola Bruni, Chiara Donati.
  • Tamoxifen 2013, Springer
    Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • Temperature and toxicology 2005, CRCnetBASE
  • Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.

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