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- "Venomous" bites from non-venomous snakes a critical analysis of risk and management of "colubrid" snake bites — Haddad and Winchester's Clinical management of poisoning and drug overdose. 4th ed. (100)
- Handbook of food toxicology — Toxicological profile for lead (100)
- Toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene — WHO Human health risk assessment toolkit chemical hazards (21)
- "Venomous" bites from non-venomous snakes a critical analysis of risk and management of "colubrid" snake bites 2011ScienceDirectThis book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity. Fills a gap in the toxinological, medical and herpetological literature by providing a comprehensive review of this entire assemblage of snakes, with particular attention given to their capacity, real or rumored, to cause harm to humans A patient-centered, evidence-based approach is applied to analyzing documented case reports of bites inflicted by approximately 100 species. Clinical management of medically significant bites from non-front-fanged colubroids is methodically reviewed, and specific recommendations are provided.
- pt. 1. Formation and analysis of hazardous compounds in heat-treated foods -- pt. 2. Health risks of acrylamide and other hazardous compounds in heat-treated foods -- pt. 3. Minimising the formation of hazardous compounds in foods during heat treatment.
- Advanced bioactive compounds countering the effects of radiological, chemical and biological agents strategies to counter biological damage 2013Springer"The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.
- Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
- Advances in biology and therapy of multiple myeloma Volume 2, Translational and clinical research 2013SpringerDespite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
- Adverse effects of engineered nanomaterials exposure, toxicology, and impact on human health. 1st ed. 2012ScienceDirectA. Engineered nanomaterials: hazard, exposure and safety assessment. Interactions with the human body / Renato Colognato ... [et al.] -- Exposure assessment / Antonio Bergamaschi, Ivo Iavicoli and Kai Savolainen -- Biomonitoring / Enrico bergamaschi and Andrea Magrini -- Critical evaluation of toxicity tests / Maria Dusinska ... [et al.] -- Computational approaches / Vidana Epa, Dave Winkler and Lang Tran -- Regulation and legislation / Maureen R. Gwinn and Birgit Sokull-Klüttgen -- B. Engineered nanomaterials: impact on human health. Respiratory system / Ken Donaldson and Craig Poland -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills and Rodger Duffin -- Neurological system / Sandra Ceccatelli and Giuseppe Bardi -- Immune system / Diana Boraschi and Albert Duschl -- Skin / Nancy A. Monteiro-Riviere and Francesca Larese Filon -- Gastrointestinal tract / Mark A. Jepson -- Reproductive toxicity / Karin Sørig Hougaard and Luisa Campagnolo -- Genotocicity and cancer / Shareen H. Doak, Ying Liu and Chunying Chen -- C. Biomedical applications of engineered nanomaterials. Diagnostic applications / Kalcheng and Zhen Cheng -- Therapeutic applications / Cyrill Bussy ... [et al.] -- Annex: synthesis of engineered nanomaterials / Muhammet S. toprak, Gulaim A. Seisenbaeva and Vadim G. Kessler.
- General -- Methodological aspects -- Physiological aspects of allelopathy -- Ecophysiology and allelopathy -- Ecological aspects of allelopathy -- Allelopathy in different environments -- Applied aspects of allelopathy.
- Analysis of pesticides in food and environmental samples 2008CRCnetBASEPesticides: classification and properties / José L. Tadeo, Consuelo Sánchez-Brunete, Lorena González -- Sample handling of pesticides in food and environmental samples / Esther Turiel, Antonio Martín-Esteban -- Analysis of pesticides by chromatographic techniques coupled with mass spectrometry / Simon Hird -- Immunoassays and biosensors / Jeanette M. Van Emon ... [et al.] -- Quality assurance / Árpád Ambrus -- Determination of pesticides in food of vegetal origin / Frank J. Schenck, Jon W. Wong -- Determination of pesticides in food of animal origin / Antonia Garrido Frenich, Jose Luis Martinez, Adrian Covaci -- Determination of pesticides in soil / Consuelo Sánchez-Brunete, Beatriz Albero, José L. Tadeo -- Determination of pesticides in water / Jay Gan, Svetlana Bondarenko -- Sampling and analysis of pesticides in the atmosphere / Maurice Millet -- Levels of pesticides in food and food safety aspects / Kit Granby ... [et al.] -- Monitoring of pesticides in the environment / Ioannus Konstantinou ... [et al.].
- Analytical and practical aspects of drug testing in hair 2007CRCnetBASEDrug incorporation into hair / Robert Kronstrand and Karen Scott -- Passive exposure, decontamination procedures, cutoffs, and bias: pitfalls in the interpretation of hair analysis results for cocaine use / David A. Kidwell and Frederick P. Smith -- Opioids testing in hair / Michel Yegles and Robert Wennig -- Hair analysis for cocaine / Carmen Jurado -- Determination of cannabinoids in human hair / Michael Uhl -- Amphetamine determination in hair / Vincent Cirimele -- Pharmaceuticals in hair / Marjorie Cheze, Marc Deveaux, Gaelle Duffort, Francis Billault, and Gilbert Pepin -- Screening strategies in hair analysis on drugs / Hans Sachs -- Clinical applications of hair analysis / Simona Pichini, Oscar Garcia-Algar, and Rafael de la Torre -- Hair in postmortem toxicology / Robert Kronstrand and Henrik Druid -- Detection of doping agents in human hair / Pascal Kintz -- Applications of hair in drug-facilitated crime evidence / Marion Villain -- Application of hair in driving-license regranting / Manfred R. Moeller, Hans Sachs, and Fritz Pragst -- Alcohol markers in hair / Fritz Pragst and Michel Yegles -- Workplace drug testing using hair samples / Thomas Cairns, Michael Schaffer, and Virginia Hill -- Metals / Jean-Pierre Goulle.
- Animal hematotoxicology a practical guide for toxicologists and biomedical researchers 2008CRCnetBASEHemopoiesis, blood cell types, and bone marrow examination -- Erythrocytes, anemias, and polycythemia -- Additional erythrocytic measurements -- Iron, associated proteins, and vitamins -- Leukocytes -- Immunotoxicology -- Hemostasis -- Pre-analytical variables -- Analytical variables and biosafety -- Data processing and interpretation.
- Animal models in toxicology. 2nd ed. 2007CRCnetBASEThe mouse -- The rat -- The hamster -- The guinea pig -- The rabbit -- The ferret -- The dog -- Primates -- The minipig -- Alternative species / Shayne C. Gad -- Clinical pathology of laboratory animals / Robert L. Hall -- Model selection and scaling / Shayne C. Gad -- Susceptibility factors / Shayne C. Gad -- Laws and regulations governing animal care and use in research / Shayne C. Gad.
- Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
- Asbestos risk assessment, epidemiology, and health effects 2005CRCnetBASE
- Assessing ocular toxicology in laboratory animals 2013SpringerOcular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
- Atlas of toxicological pathology 2014Springer"This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years."--Publisher's website.
- This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.
- Bioassays with arthropods. 2nd ed. 2007CRCnetBASE
- Biodefense research methodology and animal models 2006CRCnetBASE
- Botulinum toxin-- therapeutic clinical practice and science 2009ClinicalKeyThe new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat, such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you'll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.
- This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed -- source other than Library of Congress.
- This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
- Cancer immunotherapy paradigms, practice and promise 2013SpringerThis volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
- Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
- Carbon monoxide poisoning 2008CRCnetBASE
- Carbon nanotubes angels or demons? 2008CRCnetBASE
- Print MaterialUnit I: General principles of toxicology -- History and scope of toxicology / Michael A. Gallo -- Principles of toxicology / David L. Eaton and Steven G. Gilbert -- Mechanisms of toxicity / Zoltán Gregus -- Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Unit II: Disposition of toxicants -- Absorption, Distribution, and excretion of toxicants / Lois D. Lehman-McKeeman -- Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie -- Toxicokinetics / Danny D. Shen -- Unit III: Non-organ-directed toxicity -- Chemical carcinogens / James E. Klaunig and Lisa M. Kamendulis -- Genetic toxicology / R. Julian Preston and George R. Hoffmann -- Developmental toxicology / John M. Rogers and Robert J. Kavlock -- Unit IV: Target organ toxicity -- Toxic responses of the blood / John C. Bloom and John T. Brandt -- Toxic responses of the immune system / Norbert E. Kaminski ... [et al.] -- Toxic responses of the liver / Hartmut Jaeschke -- Toxic responses of the kidney / Rick G. Schnellmann -- Toxic responses of the respiratory system / Hanspeter R. Witschi ... [et al.] -- Toxic responses of the nervous system / Virginia C. Moser ... [et al.] -- Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes -- Toxic responses of the heart and vascular system / Y. James Kang -- Toxic responses of the skin / Robert H. Rice and Theodora M. Mauro -- Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray Jr. -- Toxic responses of the endocrine system / Charles C. Capen -- Unit V: Toxic agents -- Toxic effects of pesticides / Lucio G. Costa -- Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes -- Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand, and D. Alan Warren -- Health effects of radiation and radioactive materials / Naomi H. Harley -- Properties and toxicities of animal venoms / John B. Watkins, III -- Toxic effects of plants / Stata Norton -- Unit VI: Environmental toxicology -- Air pollution / Daniel L. Costa -- Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Unit VII: Applications of toxicology -- Food toxicology / Frank N. Kotsonis and George A. Burdock -- Analytic/forensic toxicology / Alphonse Poklis -- Clinical toxicology / Louis R. Cantilena Jr. -- Occupational toxicology / Peter S. Thorne.
- Chemical carcinogenesis 2011SpringerHistorical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
- Chemical migration and food contact materials 2007CRCnetBASEpt. 1. Regulation and quality control of chemical migration into food -- pt. 2. Assessing the risks and improving the safety of food contact materials -- pt. 3. Chemical migration from particular food contact materials.
- Chemical warfare agents chemistry, pharmacology, toxicology, and therapeutics. 2nd ed. 2008CRCnetBASEBrief history and use of chemical warfare agents in warfare and terrorism / Harry Salem, Andrew L. Ternay, Jr., and Jeffery K. Smart -- The chemistry of chemical warfare agents / Peter Kikilo, Vitaly Fedorenko, and Andrew L. Ternay, Jr. -- Chemical warfare agent threat to drinking water / Harry Salem ... [et al.] -- Health effects of low-level exposure to nerve agents / John H. McDonough and James A. Romano, Jr. -- Toxicokinetics of nerve agents / Marcel J. van der Schans, Hendrik P. Benschop, and Christopher E. Whalley -- Application of genomic, proteomic, and metabolomic technologies to the development of countermeasures against chemical warfare agents / Jennifer Sekowski and James Dillman -- Novel approaches to medical protection against chemical warfare nerve agents / Ashima Saxena ... [et al.] -- Nerve agent bioscavengers : progress in development of a new mode of protection against organophosphorus exposure / David E. Lenz ... [et al.] -- Butyrylcholinesterase and its synthetic C-terminal peptide confer in-vitro suppression of amyloid fibrils formation / Erez Podoly ... [et al.] -- A novel medical countermeasure for organophosphorus intoxication : connection to Alzheimer's disease and dementia / Edna F. R. Pereira ... [et al.] -- Inhalation toxicology of nerve agents / Paul A. Dabisch ...[et al.] -- Vesicants and oxidative stress / Milton G. Smith ...[et al.] -- Health effects of exposure to vesicant agents / Charles G. Hurst and William J. Smith -- Cyanides : toxicology, clinical presentation, and medical management / Bryan Ballantyne and Harry Salem -- Chemicals used for riot control and personal protection / Harry Salem, Bryan Ballantyne, and Sydney Katz -- Mechanism of action of botulinum neurotoxin and overview of medical countermeasure development for intoxication / Michael Adler ... [et al.] -- Ricin and related toxins : review and perspective / Charles B. Millard and Ross D. LeClaire -- Screening smokes : applications, toxicology, clinical considerations and medical management / Bryan Ballantyne and Harry Salem -- Clinical detection of exposure to chemical warfare agents / Benedict R. Capacio ... [et al.] -- Personal protective equipment (ppe) : practical and theoretical considerations / Michael R. Jones -- Chemical warfare agent decontamination from skin / Brian J. Lukey ... [et al.] -- Chemical warfare, chemical terrorism, and traumatic stress responses : an assessment of psychological impact / James A. Romano, Jr. ... [et al.] -- Emergency response to a chemical warfare agent incident : domestic preparedness, first response, and public health considerations / David H. Moore and Barbara Saunders-Price -- Emergency medical response to a chemical terrorist attack / Stephen A. Pulley and Michael R. Jones.
- The Context. Creating and Controlling Chemical Hazards: A Brief History / Jody A. Roberts -- Conferences. Stockholm, 1972: Conference on the Human Environment / Lars-Göran Engfeldt -- Rio 1992: The UN Conference on Environment and Development (The "Earth Summit") / Shelley Kath -- Johannesburg (2002) The World Summit on Sustainable Development / Shelley Kath -- International Conference on Chemicals Management 1 / Linn Persson and Viveka Bohn -- ICCM-2: Cementing Process and Making Progress toward the 2020 Goal / Melanie Ashton and Pia M. Kohler -- Global/Multilateral Instruments. The Aarhus Convention: Impact on Sound Chemicals Management with Special Emphasis on Africa / Ebeh Adayade Kodjo -- Global Collaborations in Managing Chemical and Environmental Risks: The Basel Convention--A Promising Future / Pierre Portas -- The Climate Change Convention and the Kyoto Protocol / Bert Metz -- Convention on Long-Range Transboundary Air Pollution / Johan Sliggers -- The Globally Harmonised System of Classification and Labelling of Chemicals: The System, Its History and Context, and the Future of Implementation / Cheryl Chang -- The International Code of Conduct on Distribution and Use of Pesticides / Gamini Manuweera -- The Kiev Protocol on Pollutant Release and Transfer Registers / Michael Stanley-Jones -- The Rotterdam Convention / Ernest Mashimba -- Implementing the Stockholm Convention: An Increasingly Expensive Challenge / Pia M. Kohler and Melanie Ashton -- The Vienna Convention, Montreal Protocol, and Global Policy to Protect Stratospheric Ozone / David Downie -- SAICM. Strategic Approach to International Chemicals Management: Development and Opportunities / Hamoudi Shubber -- Organizations. Food and Agriculture Organization / Mark Davis -- International Chemicals Management within the Global Environmental Governance Context / Achim Halpaap -- Managing Chemical Risks: The Role of the Chemical Industry / Michael Walls -- The Intergovernmental Forum on Chemical Safety / Jack Weinberg -- International Labour Organization's Activities in the Area of Chemical Safety / Pavan Baichoo -- Inter-Organization Programme for the Sound Management of Chemical / Jan van der Kolk -- The International Panel on Chemical Pollution / Martin Scheringer, Åke Bergman, and Heidelore Fiedler -- The Role of the International POPs Elimination Network / Mariann Lloyd-Smith -- Organization for Economic Cooperation and Development / Richard Sigman -- The Chemical Weapons Convention and the Work of the Organisation for the Prohibition of Chemical Weapons / Boitumelo V. Kgarebe and Cristina B. Rodrigues -- National and International Scientific Societies' Role in Global Collaboration in Chemicals Management / John Duffus -- The Role of United Nations Development Programme in Sound Chemicals Management / Jan van der Kolk -- United Nations Environment Programme and UNEP Chemicals / Jan van der Kolk -- United Nations Industrial Development Organization / Heinz Leuenberger and Elisa Tonda -- United Nations Institute for Training and Research / Craig Boljkovac and Jan van der Kolk -- The Contributions of the World Health Organization to Sound Chemicals Management / John A. Haines -- The Intergovernmental Panel on Climate Change / Bert Metz -- Representative Country Implementations. Chilean Approach to Chemical Safety and Management / Asish Mohapatra and Sergio Peña Neira -- Chemical Management System in China: Past, Present, Future / DaeYoung Park -- Chemicals in Egypt: A Generic Perspective / Mohamed Tawfic Ahmed and Naglaa M. Loutfi -- Capacities for Chemicals and Pesticides Management in Ghana / John A. Pwamang -- Chemicals Management and Safety in India / Ravi Agarwal -- São Tomé and Príncipe and the Issue of Persistent Organic Pollutants / Arlindo Carvalho -- Activities, Challenges, and Accomplishments of the Republic of Slovenia in the Implementation of Chemical Management Instruments / Marta Ciraj -- Implementation of the Rotterdam Convention in Third World Countries: The Tanzania Experience / Ernest Mashimba -- Regional Activities. Tripartite Environmental Collaboration between China, Japan, and Korea in Chemical Management / Dae Young Park -- REACH: Next Step to a Sound Chemicals Management / Arnold van der Wielen -- North America Cooperation in Chemical Management / Asish Mohapatra and Phil Wexler -- Regional Cooperation among South Asian Association for Regional Cooperation Countries in the Areas of Chemical and Environmental Risk Management / Lakshmi Raghupathy, Asish Mohapatra, Ravi Agarwal, and Jan van der Kolk -- Invited Essays. A Global Approach to Environmental Emergencies / Chris Dijkens -- Emerging Issues in Global Chemical Policy / Franz Perrez and Georg Karlaganis -- Financing Instruments Related to Chemicals and Waste Management / Ibrahima Sow -- Information Resources Supporting Global Chemicals Policy and Management / Asish Mohapatra and Philip Wexler -- Future Outlook. Future Outlook and Challenges / Jan van der Kolk and Ravi Agarwal.
- Chemistry and safety of acrylamide in food 2005Springer
- Cholera toxins 2009Springer
- Chromium (VI) handbook 2005CRCnetBASE
- Chrysotile asbestos 2014WHO
- Clinical neurotoxicology syndromes, substances, environments 2009ClinicalKeyClinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors, such as heavy metals and pesticides, and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection.
- Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide, and vanadium pentoxide 2006IARCMetallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
- Comparative toxicogenomics. 1st ed. 2008ScienceDirect
- Computational toxicology methods and applications for risk assessment 2013ScienceDirectComputational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
- Criminal poisoning investigational guide for law enforcement, toxicologists, forensic scientists, and attorneys. 2nd ed. 2007SpringerPoisoners throughout history -- Types of poisons -- Poisoners -- Victims -- Crime scene investigation -- The forensic autopsy -- Proving poisoning -- Poisoners in court -- Poisoning in fiction -- Conclusion.
- Current protocols in toxicology 1999-Wiley
- Current topics in neurotoxicity v. 1-, 2012-SpringerConsists of volumes that cover the latest developments in neurotoxicity studies including neurodegeneration, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.
- Cyanide in water and soil chemistry, risk, and management 2006CRCnetBASE
- Cyanobacterial toxins of drinking water supplies cylindrospermopsins and microcystins 2005CRCnetBASE
- Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
- Dermal absorption models in toxicology and pharmacology 2005CRCnetBASE
- Dermal exposure 2014WHO
- Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
- Developmental immunotoxicology 2005CRCnetBASE
- Draft toxicological profile for cadmium 2008ATSDR
- Draft toxicological profile for chromium 2008ATSDR
- Draft toxicological profile for radon 2008ATSDR
- Draft toxicological profile for RDX 2010ATSDR
- Draft toxicological profile for styrene 2007ATSDR
- Draft toxicological profile for vanadium 2009ATSDR
- Section I, Safety pharmacology: -- Introduction to safety pharmacology -- Status of safety pharmacology and present guidelines -- Central nervous system (CNS) safety pharmacology studies -- Methods in cardiovascular safety pharmacology -- Safety pharmacology of drugs for the urinary tract -- Respiratory function assays in safety pharmacology -- Metabolism pharmacology -- Peripheral nervous system -- Safety of intravenous and inhalation anesthetics -- Side effects of central analgesic drugs -- Safety pharmacology of antiinflammatory drugs -- Safety pharmacology of drugs with osteoarthritis-related activity -- Safety pharmacology of blood constituents -- Ocular toxicity tests -- Assays in endocrine safety pharmacology -- Safety assays in skin pharmacology -- Magnetic resonance imaging in pharmaceutical safety assessment -- Section II, Safety pharmacokinetics: -- Introduction -- Physicochemical properties -- In-silico ADME modeling -- Absorption-in vitro tests-cell based -- Absorption-in vitro tests-non cell based -- Distribution-in vitro tests-protein binding -- Perfused organs -- Metabolism studies in vitro and in vivo -- Distribution-across barriers -- Drug-drug interaction-enzyme induction -- Drug-drug interaction-enzyme inhibition -- Absorption -- In vivo distribution -- Distribution-in vivo-other methods -- Bioanalytical assays-Toxicokinetics -- Bioanalytical assays-liquid chromatography coupled to tandem spectrometry -- Bioanalytical assays-gas chromatography -- Bioanalytical assays-RIA/EIA -- Clinical studies-typical designs -- Pharmacogenomics in DME -- Typical PK/PD approaches -- Population kinetics in drug development -- Section III, Safety toxicology: -- Introduction -- International guidelines for the development of pharmaceutical compounds -- General toxicity -- In silico methods -- Alternative methods for carcinogenicity testing -- Genotoxicity -- Reproductive toxicology -- Application of toxicoproteomics in profiling drug effects.
- Drug safety evaluation methods and protocols 2009Springer ProtocolsDeveloping Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
- Drug testing in alternate biological specimens 2008Springer
- Drug-induced liver disease. 3rd ed. 2013ScienceDirectI. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
- I. Chapters of general nature. How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) -- Problems in toxin analysis in emergency medicine -- Analyses of chemical warefare agents and their related compounds -- B. Chapters on specific toxins. Volatile compounds -- Controlled drugs -- Psychopharmaceuticals and hypnotics -- General drugs -- Chemicals of daily necessaries -- Natural toxins and alkaloids -- Pesticides -- Miscellaneous.
- Ecology of harmful algae 2006Springer
- Ecosystems and human health toxicology and environmental hazards. Third edition [3rd ed.] 2013CRCnetBASE"The third edition of a bestseller, this book describes how chemical toxins and biological hazards impact the environment and people. Addressing how pollutants can alter the environment by contributing to global climate change, the author explores a broad range of environmental and health aspects of chemical and biological hazards. He includes numerous examples of the intimate relationship between ecosystem health and human health and emphasizes the need to consider this relationship whenever human activities are likely to have a significant environmental impact"-- Provided by publisher.
- Ecotoxicology a comprehensive treatment 2008CRCnetBASEI. Hierarchical ecotoxicology. The hierarchical science of ecotoxicology -- II. Organismal ecotoxicology. The organismal ecotoxicology context -- Biochemistry of toxicants -- Cells and tissues -- Organs and organ systems -- Physiology -- Bioaccumulation -- Models of bioaccumulation and bioavailability -- Lethal effects -- Sublethal effects -- Conclusion -- III. Population ecotoxicology. The population ecotoxicology context -- Epidemiology : the study of disease in populations -- Toxicants and simple population models -- Toxicants and population demographics -- Phenogenetics of exposed populations -- Population genetics : damage and stochastic dynamics of the germ line -- Population genetics : natural selection -- Conclusion -- IV. Community ecotoxicology. Introduction to community ecotoxicology -- Biotic and abiotic factors that regulate communities -- Biomonitoring and the responses of communities to contaminants -- Experimental approaches in community ecology and ecotoxicology -- Application of multimetric and multivariate approaches in community ecotoxicology -- Disturbance ecology and the responses of communities to contaminants -- Community responses to global and atmospheric stressors -- Effects of contaminants on trophic structure and food webs -- Conclusions -- V. Ecosystem ecotoxicology. Introduction to ecosystem ecology and ecotoxicology -- Overview of ecosystem processes -- Descriptive approaches for assessing ecosystem responses to contaminants -- The use of microcosms, mMesocosms, and field experiments to assess ecosystem responses to contaminants and other stressors -- Patterns and processes : the relationship between species diversity and ecosystem function -- Fate and transport of contaminants in ecosystems -- Effects of global atmospheric stressors on ecosystem processes -- VI. Ecotoxicology : a comprehensive treatment--conclusion -- Conclusion.
- Encyclopedic reference of immunotoxicology 2005Springer
- Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
- Environment and breast cancer 2011SpringerEpidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
- Environmental toxicology 2005ScienceDirectThe utility of zebrafish as a model for toxicological research / Michael J. Carvan III, Tisha King Heiden and Henry Tomasiewicz -- Use of fish cell lines in the toxicology and ecotoxicology of fish : piscine cell lines in environmental toxicology / N.C. Bols, V.R. Dayeh, L.E.J. Lee and K. Schirmer -- Approaches in proteomics and genomics for eco-toxicology -- Nancy D. Denslow, Iris Knoebl and Patrick Larkin -- Interactions between lipids and persistent organic pollutants in fish / Adria A. Elskus, Tracy K. Collier and Emily Monosson -- Metabolic fate of nonylphenols and related phenolic compounds in fish / Jean-Pierre Cravedi and Daniel Zalko -- Pesticide biotransformation in fish / Daniel Schlenk -- Xenobiotic receptors in fish : Structural and functional diversity and evolutionary insights / Mark E. Hahn, Rebeka R. Merson and Sibel I. Karchner -- Impacts of environmental toxicants and natural variables on the immune system of fishes / Karen G. Burnett -- Fish models of carcinogenesis / Gary K. Ostrander and Jeanette M. Rotchell -- Metallothionein : structure and regulation / Peter Kling and Per-Erik Olsson -- Cell death : investigation and application in fish toxicology / Antony W. Wood, David M. Janz and Glen J. Van Der Kraak -- Adrenal toxicology : environmental pollutants and the HPI axis / Alice Hontela -- Xenobiotic impact on corticosteroid signaling / Mathilakath M. Vijayan, Patrick Prunet and Adrienne N. Boone -- Thyroid hormones / J.G. Eales and S.B. Brown -- The biology and toxicology of retinoids in fish / D. Alsop, Glen J. Van Der Kraak, S.B. Brown and J.G. Eales -- Vitellogenesis and endocrine disruption / Naoshi Hiramatsu, Ann O. Cheek, Craig V. Sullivan, Takahiro Matsubara and Akihiko Hara -- Pharmaceuticals in the environment : drugged fish? / Vance L. Trudeau, Chris D. Metcalfe, Caroline Mimeault and Thomas W. Moon -- P-glycoproteins and xenobiotic efflux transport in fish / Armin Sturm and Helmut Segner.
- Essential concepts in toxicogenomics 2008Springer ProtocolsToxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
- Food toxicology 2001CRCnetBASE
- Foodborne diseases 2007SpringerEscherichia coli / Jianghong Meng and Carl M. Schroeder -- Listeria / Franz Allerberger -- Clostridium botulinum and Clostridium perfringens / Jim McLauchlin and Kathie A. Grant -- Yersinia enterocolitica and Yersinia pseudotuberculosis / Maria Fredriksson-Ahomaa -- Foodborne pathogenic vibrios / T. Ramamurthy and G. Balakrish Nair -- Enterococcus and its association with foodborne illness / Simona F. Oprea and Marcus J. Zervos -- Foodborne viral hepatitis / Hazel Appleton ... [et al.] -- Gastroenteric virus / Miren Iturriza-Gómara, Chris I. Gallimore, and Jim Gray -- Cryptosporidium / Huw V. Smith -- Toxoplasma gondii / Dolores E. Hill ... [et al.] -- Aflatoxins : background, toxicology, and molecular biology / Joan W. Bennett, S. Kale, and Jiujiang Yu -- Scombroid fish poisoning / Elijah W. Stommel -- Pathogen control in meat and poultry production: implementing the USDA food safety and inspection service's hazard analysis and critical control point system / Moshe S. Dreyfuss ... [et al.] -- Use of antimicrobials in food animal production / Frank M. Aaestrup and Lars B. Jensen -- Alternatives to antimicrobials* / Toni L. Poole, Todd R. Callaway, and David J. Nisbet -- Microbial risk assessment / Carl M. Schroeder -- Food irradiation and other sanitation procedures / Donald W. Thayer -- Molecular techniques of detection and discrimination of foodborne pathogens and their toxins / Steven L. Foley and Kathie A. Grant -- Future directions in food safety* / Ross C. Beier and Suresh D. Pillai.
- Fundamentals of pharmaceutical nanoscience 2013SpringerNanoscience and nanotechnology overview -- Liposome preparation and characterization -- Solid polymeric nanoparticles -- Lipid nanoparticles -- Polymeric vesicles -- Low molecular weight amphiphile micelles -- Polymeric micelles -- Niosomes -- Quantum dots -- Magnetic particles -- Drug nanoparticles -- Polymeric pro-drugs -- Therapeutic Applications of pharmaceutical nanosystems -- Drug solubilisation -- Gene therapy -- Chemotherapy -- Tissue engineering -- Anti-infectives -- Vaccination -- Anti-arthritic drugs -- Imaging agents -- Commercial exploitation of pharmaceutical nanosystems -- Future perspectives -- Multiple Choice -- Problem Sets -- Case Studies -- Suggested Reading.
- Genomic approaches for cross-species extrapolation in toxicology proceedings from the Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolations, 18-22 July 2004, Portland, Oregon, USA 2007CRCnetBASE"Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
- Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.]. Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
- Genotoxicity and DNA repair a practical approach 2014Springer ProtocolsGenotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
- The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA) is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions. This volume considers one of ICH's major categories, Safety, covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but in most cases there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances. Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written, why are some topics ignored, and why have some initial guidance proposals have been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today.
- Goldfrank's Toxicologic emergencies. Tenth edition [10th ed.]. 2015AccessEmergency MedicinePt. A: The general approach to medical toxicology -- Pt. B: The fundamental principles of medical toxicology -- Sect. I: Biochemcial and molecular basis -- Sect. II: Pathophysiologic basis: organ systems -- Sect. III: Special populations -- Pt. C: The clinical basis of medical toxicology -- Sect. I: A: Analgesics and antinflammatory medications -- B: Food, diet, and nutrition -- C: Pharmaceuticals -- D: Antimicrobials -- E: Cardiopulmonary medications -- F: Anesthetics and related medications -- G: Psychotropics -- H: Substances of abuse -- I: Metals -- J: Household products -- K: Pesticides -- L: Natural toxins and envenomations -- M: Occupational and environmental toxins -- N: Disaster preparedness -- Sect. II: Poison centers and epidemiology.
- ER-bound steps in the biosynthesis of G protein-coupled receptors / Christian Nanoff and Michael Freissmuth -- Role of chaperones in G Protein coupled receptor signaling complex assembly / Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- GPCR oligomerization: contribution to receptor biogenesis / Kathleen Van Craenenbroeck -- The functional size of GPCRs: monomers, dimers or tetramers? / Darlaine Pétrin and Terence E. Hébert -- Regulation of post-Golgi traffic of G protein-coupled receptors / Guangyu Wu -- Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- Regulatory processes governing the cell surface expression of LH and FSH receptors / Deborah L. Segaloff -- Chaperone-mediated assembly of G protein complexes / Barry M. Willardson and Christopher M. Tracy -- Synthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / Jane Dingus and John D. Hildebrandt -- Preferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / Janet D. Robishaw -- G Protein trafficking / Philip B. Wedegaertner -- Differential assembly of GPCR signaling complexes determines signaling specificity / Pascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- GPCR and voltage-gated calcium channels (VGCC) signaling complexes / Christophe Altier -- Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn.
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Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides one-click access to important clinical resources; includes evidence-based diagnosis and treatment guidelines, Books, EBM articles, Ovid MEDLINE, Drug facts and comparisons, Drug interaction facts, guidelines from National Guideline Clearinghouse, patient handouts (English and Spanish), and local content.ClinicalKey provides access to textbooks, electronic journals, practice guidelines, drug information, and patient education handouts.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.