Books by Subject

all 248 titles


  • This annual report details NIH-supported and -conducted Alzheimer's disease research initiatives, objectives, and advances during calendar year 2014 and early 2015. New findings and investments described in this report are organized in categories determined by the Common Alzheimer Disease Research Ontology (CADRO) of the International Alzheimer's Disease Research Portfolio (IADRP).
  • 2010From: ProQuest Safari
    Timothy Kachinske, Judith Kachinske.
    Getting started as a Grant writer -- Finding and securing a Grant-writing position -- Expertise -- Research -- Managing relationships -- Writing -- Organizing information -- Queries and short proposals -- Proposals for projects, programs, or bricks and mortar -- Proposals for endowment support -- Federal Grants -- Managing Grant awards.
  • edited by Michael E. Hochman.
    PrintStatus: Not Checked OutLane Catalog Record
    Sect. 1: Preventive medicine -- Preventing diabetes: the diabetes prevention program -- A comparison of different dieting strategies -- Aspirin for the primary prevention of cardiovascular disease: the physician's health study and the women's health study -- Postmenopausal hormone therapy: the women's health initiative -- The European randomized study of screening for prostate cancer (ERSPC) -- The cochrane review of screening mammography -- The human papillomavirus vaccine: the future II trial -- Sect. 2: Internal medicine -- Arrhythmia suppression following myocardial infarction: the CASt trial -- Choosing first-line therapy for hypertension: the ALLHAT trial -- Statins in healthy patients with an elevated c-reactive protein: the JUPITER trial -- Rate control versus rhythm control for atrial fibrillation: the AFFIRM trial -- Lenient versus strict heart rate control for atrial fibrillation: the RACC II trial. -- Beta blockers for systolic heart failure: the MERIT-HF trial -- Initial treatment of stable coronary artery disease: the COURAGE trial -- Treating elevated blood sugar levels in patients with type 2 diabetes: the United Kingdom prospective diabetes study (UKPDS) -- Intensive versus conservative blood sugar for patients with type 2 diabetes: the ACCORD trial -- The African American heart failure trial (A-HeFT) -- Early versus delayed antiretroviral therapy for patients with HIV: the NA-ACCORD study -- Early versus late initiation of dialysis: the IDEAL trial -- Early goal-directed therapy in sepsis -- Red cell transfusion in critically ill patients: the TRICC trial -- Pulmonary artery catheters in critically ill patients -- Step-up versus step-down therapy for dyspepsia: the DIAMOND trial -- Opioids for chronic noncancer pain -- Sect. 3: Surgery -- Perioperative beta blockers in noncardiac surgery: the POISE trial -- Cardiac stents versus coronary artery bypass surgery for severe coronary artery disease: the SYNTAX trial -- Carotid endarterectomy for asymptomatic carotid stenosis: the ACST trial -- A trial of arthroscopic knee surgery -- Surgery versus rehabilitation for chronic low back pain: the MRC spine stabilization trial -- Mastectomy versus lumpectomy for invasive breast cancer: the B-06 trial -- Long-term impact of bariatric surgery: the Swedish obese subjects study -- Sect. 4: Obstetrics -- The Canadian multicenter post-term pregnancy trial (CMPPT) -- Antepartum glucocorticoids in premature labor -- Sect. 5: Pediatrics -- Treatment of acute otitis media in children -- A trial of early ear tube placement in children with persistent otitis media -- Inhaled corticosteroids for mild persistent asthma: the START trial -- The multimodal treatment study of children with attention deficit/hyperactivity disorder (MTA) -- Measles, mumps, and rubella vaccination and autism -- Sect. 6: Radiology -- Magnetic resonance imaging for low back pain -- Screening for coronary artery disease in asymptomatic patients with diabetes: the DIAD study -- Diagnosing acute pulmonary embolism: the Christopher study -- Identifying children with low-risk head injuries who do not require computed tomography -- Sect. 7: Neurology and psychiatry -- Thrombolysis 3 to 4.5 hours after an acute ischemic stroke: the ECASS III trial -- Initial treatment of depression -- Behavioral versus pharmacological treatment for insomnia in the elderly -- Sect. 8: Systems-based practice -- The group health medical home demonstration -- A program to improve care coordination at hospital discharge: project RED -- Reducing catheter-related blood stream infections in the intensive care unit: the keystone ICU project -- Early palliative care in non-small-cell lung cancer -- Directly observed therapy for the treatment of tuberculosis in Baltimore.
  • 2012From: CRCnetBASE
    Richard Chin.
    1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results.
  • 2007Click LINK above for Print location/circulation status.
    2007From: CRCnetBASE
    Shein-Chung Chow, Mark Chang.
  • 2012From: CRCnetBASE
    Shein-Chung Chow, Mark Chang.
    Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
  • 2012From: Thieme Book
    edited by Mohit Bhandari, Bernd Robioneck ; associate editor, Emil Schemitsch ; managing editor, Sheila Sprague ; with contributions by Volker Alt ... [et al.].
    1. Factorial Randomized Trials -- Summary -- Introduction -- Randomized clinical trial design strategies with multiple interventions -- Selecting a factorial randomized design -- Conclusion -- 2. Expertise-based randomized trials -- Summary -- Introduction -- Conventional RCT design -- Expertise-based RCT design -- Challenges of expertise-based RCTs -- Independent assessor -- Balanced and consecutive or random contributions to screening pool -- Perceived equivalence between practices -- Conclusion -- 3. Randomization systems and technology -- Summary -- Introduction -- Methods of patient allocation -- Other considerations -- Conclusion -- 4. Blinding and concealment -- Summary -- Introduction -- Concealment -- Blinding -- Conclusion -- 5. Composite outcome in orthopaedics: understanding the concepts -- Summary -- Introduction -- Rationale for use of a composite outcome -- Limitations of using composite outcomes -- Guidelines for creating a "good" composite outcome -- Reporting and interpreting composite outcomes -- Conclusion -- 6. Adjudication of outcomes-systems and approaches -- Summary -- Introduction -- Importance of adjudication -- Process of adjudication -- Existing methods of adjudication -- Web-based adjudication -- Conclusion -- 7. Subgroup analyses -- Summary -- Introduction -- Subgroup analysis defined -- Design of a subgroup analysis -- Reporting -- Interpretation -- Conclusion -- 8. Trial management-advance concepts and systems -- Summary -- Introduction -- Phases of clinical trials -- Common considerations in conducting a clinical trial -- Trial committees -- The search for funding -- Conclusion 9. Case-control studies -- Summary -- Introduction -- Definition of a case-control study -- Conclusion -- 10. Cohort studies -- Summary -- Introduction -- Cohort studies in the hierarchy of evidence -- Types of cohort study designs -- Methods for reducing confounding and assessing causality -- A checklist to evaluate or improve the strength of evidence -- Conclusion --; 11. Survey Design -- Summary -- Introduction -- Identifying a research question -- Survey development -- Survey design -- Using exiting surveys -- survey validataion -- Pilot testing -- Survey administration -- Ethical considerations -- Financial considerations -- Conclusion -- 12. Qualitative studies -- Summary -- Introduction -- What is qualitative research? -- How is qualitative research done? -- Conclusion -- 13. Economic analysis -- Summary -- Introduction -- Theoretical background -- Conducting health economics studies -- Conclusion -- 14. Literature searches -- Summary -- Introduction -- When to conduct a literature search -- How to conduct a literature search -- Study selection -- Assessing methodological quality of studies -- Data extraction and analysis -- Conclusion -- 15. Summary -- Introduction -- the P value does not assess the magnitude of a treatment effect -- The challenge of comparing results across studies -- Types of effect sizes -- Confidence intervals for effect sizes -- Use of effect size in meta-analysis -- Conclusion -- 16. Fixed effects versus random effects -- Summary -- Introduction -- the data pool: fixed effects versus random effects -- Deciding which model to use -- Conclusion -- 17. Heterogeneity -- Summary -- Introduction -- Heterogeneity defined -- Identifying heterogeneity -- Dealing with heterogeneity -- Conclusion -- 18. Uncovering publicatiion bias -- Summary -- Introduction -- Authors and publication bias -- Detecting and adjusting for publication bias -- Minimizing the effect of publication bias -- A possible solution: trial registers -- Conclusion -- 19. Statiecal pooling - programs and systems -- Summary -- Introduction -- Selectin the appropriate programs and systems: factors to consider --Review of programs and systems -- Types of programs and systems -- Recommendations -- Conclusion -- 20. Meta-analysis of observational studies -- Summary -- Introduction -- The observational data dilemma -- Conclusion -- 21. Meta-regression -- Summary -- Introduction -- Heterogeneity and meta-regression -- Meta-regression mechanics -- Interpreting a meta-regression -- Limitations of meta-regression -- Conclusion -- 22. Preparing a statistical analysis plan -- Summary -- Introduction -- Data management -- Statistical procedures -- Data safety and monitoring board -- Sample size -- Interim analysis -- Reports to investigators -- Sensitivity analysis -- Tables of presentation and publication -- Software -- Reporting guidelines -- General policies -- Privacy considerations -- Apendices -- What is in the literature about SAP? -- Conclusion --; 24. Survival analysis -- Summary -- Introduction -- Documenting time-to-event (survival) data -- the rationale for time-to-event (survival) analysis -- Methods for survival analysis -- Comparing groups -- Practical considerations in the desin of time-to-event studies -- Conclusion -- 25. Interim analyses in randomized trials -- Summary -- Introduction -- Interim analysis defined -- Design of an interim analysis -- Data monitoring committees -- Consequences of stopping early for benefit -- Conclusion -- 26. Conflicts of interest reporting -- Summary -- Introduction -- Legal implications -- Types of conflict of interest -- Who should disclose conflicts of interest? -- When must conflicts of interest be disclosed? -- Guidelines and recommendations for disclosure -- Why must personal financial interests be disclosed? -- Alternatives to disclosure policies -- Conclusion -- 27. Authorship-modern approaches and reporting -- Summary -- Introduction -- Academic stream -- Educational stream -- Industrial stream -- Popular media stream -- Conclusion -- 28. Randomized trials reporting checklists -- Summary -- Introduction -- Consort statement -- Nonpharmacological trials -- NPT extension to consort statement -- CLEAR NPT -- Conclusion -- 29. Observational studies reporting checklists -- Summary -- Introduction -- Checklist for observational studies: the STROBE statement -- Guide to investigators: how to used the STROBE statement -- The STROBE statement: explanations of checklist items -- Conclusion -- 30. Meta-analysis reporting checklists -- Summary -- Introduction -- Meta-analysis reporting checklists -- Conclusion -- Resources and contacts for surgical research -- Summary -- Introduction -- Mentorship -- Graduate programes -- Online courses -- Textbooks and journals -- Courses and workshops -- Contract research organizations -- Conclusion -- Glossary of terms.
  • 2014From: Springer
    Vijay C. Verma, Alan C. Gange, editors.
    In recent years there has been significant attention paid on the endophytic research by various groups working within this domain. Mutualistic endophytic microbes with an emphasis on the relatively understudied fungal endophytes are the focus of this special book. Plants are associated with micro-organisms: endophytic bacteria and fungi, which live inter- and intra-cellularly without inducing pathogenic symptoms, but have active biochemical and genetic interactions with their host. Endophytes play vital roles as plant growth promoters, biocontrol agents, biosurfactant producers, enzymes and secondary metabolite producers, as well as providing a new hidden repertoire of bioactive natural products with uses in pharmaceutical, agrochemical and other biotechnological applications. The increasing interest in endophytic research generates significant progress in our understanding of the host-endophyte relationship at molecular and genetic level. The bio-prospection of microbial endophytes has led to exciting possibilities for their biotechnological application as biocontrol agent, bioactive metabolites, and other useful traits. Apart from these virtues, the microbial endophytes may be adapted to the complex metabolism of many desired molecules that can be of significant industrial applications. These microbes can be a useful alternative for sustainable solutions for ecological control of pests and diseases, and can reduce the burden of excess of chemical fertilizers for this purpose. This book is an attempt to review the recent development in the understanding of microbial endophytes and their potential biotechnological applications. This is a collection of literature authored by noted researchers having signatory status in endophytic research and summarizes the development achieved so far, and future prospects for further research in this fascinating area of research.
  • 2007From: Springer
    Thorsten M. Buzug (ed.).
  • 2010From: CRCnetBASE
    edited by Cynthia M. Kuhn, George F. Koob.
    Advances in animal models of relapse for addiction research / Friedbert Weiss -- Application of chronic extracellular recording method to studies of cocaine self-administration : method and progress / Laura L. Peoples, Alexai V. Kravitz, and Karine Guillem -- Neurochemistry of addiction : monitoring essential neurotransmitters of addiction / Stefan G. Sandberg and Paul A. Garris -- Alcohol craving and relapse prediction : imaging studies / Andreas Heinz ... [et al.] -- Integrating behavioral and molecular approaches in mouse : self-administration studies / Danielle L. Graham and David W. Self -- Neuroeconomics : implications for understanding the neurobiology of addiction / Michael L. Platt ... [et al.].
  • Cheryl Iverson (chair) [and others].
    PrintStatus: Not Checked OutLane Catalog Record
    Types of articles -- Manuscript preparation -- References -- Visual presentation of data -- Ethical and legal considerations -- Editorial assessment and processing -- Grammar -- Punctuation -- Plurals -- Capitalization -- Correct and preferred usage -- Non-English words, phrases, and accent marks -- Medical indexes -- Abbreviations -- Nomenclature -- Eponyms -- Greek letters -- Units of measure -- Numbers and percentages -- Study design and statistics -- Mathematical composition -- Typography -- Manuscript editing and proofreading -- Glossary of publishing terms -- Resources.
    Also available: Print – 2007
  • 2009From: Springer
    David R. Gross.
    General principles of animal selection and normal physiological values -- Preanesthesia, anesthesia, chemical restraint, and the recognition and treatment of pain and distress -- Normal cardiac function parameters -- Measuring cardiac function -- Measuring vascular function and ventricular/arterial coupling dynamics -- Isolated heart preparations, problems, and pitfalls -- Cardiovascular effects of anesthetics, sedatives, postoperative analgesic agents, and other pharmaceuticals -- Naturally occurring and iatrogenic animal models of valvular, infectious, and arrhythmic cardiovascular disease -- Iatrogenic models of ischemic heart disease -- Iatrogenic, transgenic, and naturally occurring models of cardiomyopathy and heart failure -- Iatrogenic, congenic, and transgenic models of hypertension -- Naturally occurring, iatrogenic and transgenic models of atherosclerotic disease -- Animal models for the study of neurohumeral and central neural control of the cardiovascular system -- Other transgenic animal models used in cardiovascular studies
  • compiled by Anne-Laure Bourre.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014From: ProQuest Ebook Central
    Xiao-Hua Zhou, Chuan Zhou, Danping Liu, Xiaobo Ding.
    Missing data concepts and motivating examples -- Overview of methods for dealing with missing data -- Design considerations in the presence of missing data -- Crosssectional data methods -- Longitudinal data methods -- Survival analysis under ignorable missingness -- Nonignorable missingness -- Analysis of randomized clinical trials with noncompliance.
  • 2012From: ProQuest Ebook Central
    by Adam Gacek.
    The main sequence is comprised of approximately 200 entries dealing with almost all aspects of Arabic manuscript studies (codicology and paleography); includes appendices covering abbreviations, letterforms, såurah-headings, major reference works, and a guide to the description of manuscripts, as well as charts of major historical periods and dynasties.
  • 2008From: CRCnetBASE
    edited by Stephen A. Osmani, Gustavo H. Goldman.
  • 2017Limited to 1 simultaneous usersFrom: ProQuest Ebook Central
    edited by Margaret J. Foster, Sarah T. Jewell.
    This book guides librarians in defining and marketing their services, covering topics such as co-authorship, stakeholders, developing documentation and conducting the reference interview, systematic reviews standards, search strategy techniques, and best practices for reporting the findings.
  • Eric Tatt Wei Ho.
    The fruit fly, Drosophila melanogaster, is a key model species for biological research. Trained humans can manipulate, inspect and dissect individual flies, but these operations are often rate-limiting bottlenecks for screening and experimentation. Here I present a high-speed, economical robot for handling non-anesthetized adult flies. Using machine vision the robot tracks a fly's thorax and gently grabs it ~400 ms after targeting. The robot can then translate and rotate the picked fly, inspect its phenotype, dissect or release it, and thereby rapidly prepare multiple flies sequentially for a wide range of experimental formats. In one illustration, the robot restrained flies and dissected the cuticle to permit two-photon imaging of neural dynamics. In another, the robot sorted flies by sex. The robot's tireless capacity for accurate, repeatable manipulations will enable experiments and biotechnology applications that would otherwise be totally infeasible, especially those requiring high-throughput capture, testing and assessment of individual fly attributes.
  • 2017From: ScienceDirect
    edited by Morteza Jalali, Francesca Y.L. Saldanha, Mehdi Jalali ; foreword by Dame Sally Davies.
  • Juliet Corbin, International Institute for Qualitative Methodology, Anselm Strauss.
    PrintStatus: Not Checked OutLane Catalog Record
    Inspiration and background -- Theoretical foundations -- Practical considerations for getting started -- Prelude to analysis -- Strategies for qualitative data analysis -- Memos and diagrams -- Theoretical sampling -- Context -- Process -- Techniques for achieving theoretical integration -- The use of computer programs in qualitative data analysis -- Open coding: identifying concepts -- Developing concepts in terms of their properties and dimensions -- Analyzing data for context -- Bringing process into the analysis -- Integrating categories -- Writing theses, monographs, and dissertations, and giving talks -- About your research -- Criteria for evaluation -- Student questions and answers.
  • 2008From: SAGE
    Juliet Corbin and Anselm Strauss.
    Introduction -- Practical considerations -- Prelude to analysis -- Strategies for qualitative data analysis -- Introduction to context, process and theoretical integration -- Memos and diagrams -- Theoretical sampling -- Analyzing data for concepts -- Elaborating the analysis -- Analyzing data for context -- Bringing process into the analysis -- Integrating categories -- Writing theses, monographs, and giving talks -- Criterion for evaluation -- Student questions and answers.
  • 2011From: CRCnetBASE
    Scott M. Berry, Bradley P. Carlin, J . Jack Lee, and Peter Müller
    Chapter 1. Statistical approaches for clinical trials -- Chapter 2. Basics of Bayesian inference -- Chapter 3. Phase I studies -- Chapter 4. Phase II studies -- Chapter 5. Phase III studies -- Chapter 6. Special topics.
  • 2009From: CRCnetBASE
    Lyle D. Broemeling.
    Chapter 1. Introduction to Agreement -- Chapter 2. Bayesian Methods of Agreement for Two Raters -- Chapter 3. More than Two Raters -- Chapter 4. Agreement and Correlated Observations -- Chapter 5. Modeling Patterns of Agreement -- Chapter 6. Agreement with Quantitative Scores -- Chapter 7. Sample Sizes for Agreement Studies.
  • Brianna Rego.
    In 1952, the largest manufacturer of cigarettes, Philip Morris, founded a Department of Research and Development (R& D) that would ultimately elevate the company to its dominating role in the tobacco landscape. As revealed through internal industry documents available online and released through litigation, this study highlights both the role of scientific research in a controversial industry, and the role of individual researchers in the unbridled growth of Big Tobacco during the second half of the twentieth century. Despite extensive research, industry results were rarely published and never without extensive scrutiny by industry executives and lawyers. This scientific silence is in stark contrast to the industry's public stance of denying the health hazards of smoking. The extent to which the tobacco men understood the hazards of their products--and the specific details of several research projects on the dangers of smoking--are discussed. The history of the Department of Research at Philip Morris demonstrates that just as public concern was growing that smoking might be dangerous, the tobacco industry was actively pursuing research proving the very thing they were trying to convince the public was a non-issue: that smoking is harmful.
  • edited by Gesa E. Kirsch and Liz Rohan ; with a foreword by Lucille M. Schultz.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction: The role of serendipity, family connections, and cultural memory in historical research / Gesa E. Kirsch and Liz Rohan -- The accidental archivist : embracing chance and confusion in historical scholarship / David Gold -- Being on location : serendipity, place, and archival research / Gesa E. Kirsch -- Getting to know them : concerning research into four early women writers / Christine Mason Sutherland -- Making connections / Alicia Nitecki -- Traces of the familiar : family archives as primary source material / Wendy B. Sharer -- The biography of a graveyard / Ronald R. Stockton -- In a treeless landscape : a research narrative / Kathleen Wider -- My grandfather's trunk / Barry Rohan -- Colonial memory, colonial research : a preamble to a case study / Victor Villanueva -- Unbundling : archival research and Japanese American communal memory of U.S. Justice Department internment, 1941-45 / Gail Y. Okawa -- Mississippi on my mind / W. Ralph Eubanks -- Dreaming Charles Eastman : cultural memory, autobiography, and geography in indigenous rhetorical histories / Malea Powell -- Cultural memory and the lesbian archive / Kate Davy -- "I see dead people" : archive, crypt, and an argument for the researcher's sixth sense / Elizabeth (Betsy) Birmingham -- Stitching and writing a life / Liz Rohan -- When two stories collide, they catch fire / Anca Vlasopolos -- Stumbling in the archives : a tale of two novices / Lisa Mastrangelo and Barbara L'Eplattenier.
  • 2009From: ProQuest Ebook Central
    Sharyl J. Nass, Laura A. Levit, and Lawrence O. Gostin, editors ; Committee on Health Research and the Privacy of Health Information, the HIPAA Privacy Rule, Board on Health Sciences Policy, Board on Health Care Services.
    Introduction -- The value and importance of health information privacy -- The value, importance, and oversight of health research -- HIPAA, the privacy rule, and its application to health research -- Effect of the HIPAA privacy rule on health research -- A new framework for protecting privacy in health research.
  • 2010From: Springer
    Michael F. Ochs, John T. Casagrande, Ramana V. Davuluri, editors.
  • 2016From: Springer
    Seward B. Rutkove.
    Foreword -- PART 1: Basic considerations -- 1. So do you really want to pursue research? -- 2. What's in store: The brighter side of medical research -- 3. What's in store: The darker side of medical research -- 4. One degree of separation -- 5. Choosing and working with a mentor -- 6. Identifying a research niche you can call your own -- 7. Useful Definitions -- PART 2: Research Foundations and Structures -- 8. The Institutional Review Board: Do's, Don'ts, and Nevers... -- 9. Animal Care and Use Committees -- 10. Research beyond humans and vertebrates -- 11. Hiring Research Staff -- 12. Strategy and Tactics: Running a Successful Laboratory -- 13. Everything you ever wanted to know about collaboration Part 3: Successful Paper and Grant Writing -- 14. Writing a successful research paper. I -- Up to the point of submission -- 15. Writing a successful research paper. II -- Revising, resubmitting, and post-acceptance tasks -- 16. Funding: An overview -- 17. Where to apply for funding: making the right choices -- 18. Writing a winning grant application -- 19. Grant budgeting -- 20. Grant writing: Pearls and lumps of coal -- 21. Research Training, Fellowship, and Career grants -- 22. Grant review from the inside -- 23. Interpreting your reviews -- 24. To resubmit or not resubmit and how to do it -- Part 4: Good presentations, conferencing, networking, and other useful tools -- 25. The art of good presentation -- 26. Effective conferencing -- 27. Networking in the 21st century -- 28. Conflicts of interest -- 29. Scientific conduct and misconduct: what is right and proper, what is not, and what is somewhere in the middle -- 30. Article review and reading: being efficient and as thorough as you need to be -- 31. Patents -- 32. Working with industry -- Part 5: Career choices and life lessons -- 33. Jobs in biomedical science: seeking, landing, and changing -- 34. Academic Promotion and Titles -- 35. On being a mentor -- 36. Yardsticks of success -- 37. Research Life Lesson #1: Everything takes longer than you think, so plan for it -- 38. Research life lesson #2: A person's research is endlessly important to them -- 39. Research Life lesson #3: Balance, timing, cycles and seeing the big picture -- 40. Research Life Lesson #4: Your career is an ultramarathon, not a sprint -- 41. Conclusion: Nothing satisfies like meaningful work -- Acknowledgements.
  • 2006From: Cambridge
    Phil Dee ; with cartoons by Chris McLeod.
    pt. 1. The first couple of years -- Choosing and handling your PhD adviser -- Motivation, time management and multitasking -- Handling the literature -- Report writing -- Powerful presentations -- pt. 2. The end of the beginning -- Writing papers and abstracts -- Conferences and poster presentations -- Writing and defending your thesis -- Coping with pressure and stress -- pt. 3. The transition to postdoctoral research -- The transition from graduate student to post-doc -- Collaboration and visiting other labs -- Supervising students -- Teaching -- Writing grant proposals and fellowship applications -- pt. 4. Making it in science -- Culturing your image -- You and your big ideas -- Planning for a permanent job -- Do you have Principal Investigator (PI) potential?
  • 2007From: Springer
    edited by Stanley P.L. Leong.
    Historical perspective and evolving concerns for human research / Bernard Lo and Nesrin Garan -- Cancer trials and the Institutional Review Board (IRB) / Scott Kurtzman and Zita Lazzarini -- NCI's cancer therapy evaluation program: a commitment to treatment trials / Jeffrey S. Abrams, Anthony Murgo and Michaele C. Christian -- Practical guide for cancer clinical investigators / Steven Hirschfeld -- The role of cooperative groups in cancer clinical trials / Ann M. Mauer, Elizabeth S. Rich and Richard L. Schilsky -- The advocate role in clinical study development and partnering with patient advocates in your local institution / Barbara Parker -- The National Breast Cancer Coalition: setting the standard for advocate collaboration in clinical trials / Fran Visco -- The role of the principal investigator in cancer clinical trials / Stanley P.L. Leong -- The audit process and how to ensure a successful audit / Y. Nancy You, Lisa Jacobs, Elizabeth Martinez and David M. Ota -- The privacy rule (HIPAA) as it relates to clinical research / John M. Harrelson and John M. Falletta -- The Commission on Cancer, American College of Surgeons' response to HIPAA / E. Greer Gay -- Ethical and legal issues in the conduct of cancer clinical trials / Gerianne J. Sands and Peggy A. Means -- The role of the Office of Research Integrity in cancer clinical trials / Peter Abbrecht, Nancy Davidian, Samuel Merrill and Alan R. Price -- Strategies for the administration of a clinical trial infrastructure: lessons from a comprehensive cancer center / Leonard A. Zwelling and Carleen A Brunelli -- The clinical research process: building a system in harmony with its users / Greg Koski -- Cancer research and clinical trial in action: an important exercise before you embark on your study / Stanley P.L. Leong, Larry Carbone and Scott Kurtzman.
    Also available: Print – 2007
  • 2016From: Springer
    Daniela Cristina Stefan, editor.
    1.Introduction: the need to conduct cancer research in developing countries -- 2.Steps of a research study: from research question to publication -- 3.Types of research designs -- 4.Clinical research in developing countries: An overview -- 5.The research protocol -- 6.Ethics of conducting cancer research in developing countries -- 7.Data management and statistics -- 8.Funding For Cancer Research and Clinical Studies in Low and Middle-Income Countries -- 9.International Collaboration in Cancer Research -- 10.Publication and dissemination of research findings.
  • 2006From: NLM
    NLM Board of Regents.
  • 2007From: NCBI Bookshelf
    Karen Patrias ; Daniel L. Wendling, technical editor.
    Citing Published Print Documents -- 1. Journals -- 2. Books -- 3. Conference Publications -- 4. Scientific and Technical Reports -- 5. Dissertations and Theses -- 6. Bibliographies -- 7. Patents -- 8. Newspaper Articles -- 9. Maps -- 10. Legal Documents -- Citing Unpublished Material -- 11. Forthcoming ("in press") -- 12. Papers and Poster Sessions Presented at Meetings -- 13. Letters and Other Personal Communication -- 14. Manuscripts -- Citing Audio and Visual Media (audiocassettes, videocassettes, slides, photographs, etc.) -- 15. Books and Other Individual Titles in Audiovisual Formats -- 16. Journals in Audiovisual Formats -- 17. Prints and Photographs -- Citing Material on CD-ROM, DVD, or Disk -- 18. Books and Other Individual Titles on CD-ROM, DVD, or Disk -- 19. Journals on CD-ROM, DVD, or Disk -- 20. Databases on CD-ROM, DVD, or Disk -- 21. Computer Programs on CD-ROM, DVD, or Disk -- Citing Material on the Internet (Online) -- 22. Books and Other Individual Titles on the Internet -- 23. Journals on the Internet -- 24. Databases/Retrieval Systems on the Internet -- 25. Web Sites -- 26. Electronic Mail and Discussion Forums -- Appendixes -- Appendix A: Abbreviations for Commonly Used English Words in Journal Titles -- Appendix B: Additional Sources for Journal Title Abbreviations -- Appendix C: Abbreviations for Commonly Used English Words in Bibliographic Description -- Appendix D: ISO Country Codes for Selected Countries -- Appendix E: Two-Letter Abbreviations for Canadian Provinces and Territories and U.S. States and Territories -- Appendix F: Notes for Citing MEDLINE® /PubMed® -- Appendix: Content Updates.
  • 2009From: ScienceDirect
    2009From: ClinicalKey
    edited by David Robertson, Gordon H. Williams.
  • 2006From: Ovid
    R. Brian Haynes, David L. Sackett, Gordon H. Guyatt, Peter Tugwell.
    Forming research questions -- Conducting systematic reviews -- Finding information about the burden of disease -- An introduction to performing therapeutic trials -- The tactics of performing therapeutic trials -- The principles behind the tactics of performing therapeutic trials -- Testing quality improvement interventions -- Evaluating diagnostic tests -- Determining prognosis and creating clinical decision rules -- Assessing claims of causation -- Generating outcome measurements, especially for quality of life -- Becoming a successful clinician-investigator -- Preparing a research protocol to improve its chances for success -- Online data collection -- Analyzing data -- Preparing reports for publication and responding to reviewers' comments -- Dealing with the media.
    Also available: Print – 2006
  • 2015From: Springer
    John G. Brock-Utne.
    This book provides insights into how to be a productive clinical researcher via real-life case examples of successful clinical research -- and also clinical research gone awry. Through these examples of success and failure, the book develops a blueprint for building a career in clinical research. Future medical practice depends on the quality of the clinical trials to which drugs, devices, and treatment procedures are subjected today. However, clinical trials are not easy to do, and many physicians and health care providers who attempt clinical research struggle in this endeavor, primarily because of lack of instruction. Clinical Research aims to fill the gap between training and research through case studies of a long-time clinical researcher's rich and varied experiences.
  • 2009From: Thieme Book
    edited by Mohit Bhandari, Anders Joensson.
    Why we need clinical research -- Historical perspectives of clinical research -- Evidence-based surgery defined -- Myths and misconceptions about evidence-based medicine -- Becoming an evidence-based surgeon -- Principles of clinical research -- Various research design classifications -- Hierarchy of research studies: from case series to meta-analyses -- Randomized and nonrandomized studies -- Understanding research study design -- Clinical case series -- Case-control study -- Prospective cohort study -- Randomized trial -- Meta-analysis -- Economic analysis -- Diagnostic study -- Reliability study -- Understanding outcomes measurement -- Classification of outcomes -- What makes an outcome measure useful -- Common generic outcome scales for surgeons -- Common disease-specific outcome scales for surgeons -- Understanding treatment effects -- Common ways to present treatment effects -- Confidence interval defined -- P value defined -- Errors in hypothesis testing -- Clinical versus statistical significance -- Practice of clinical research -- Planning a research study -- Requirements of a clinical research proposal -- Identification of a good research question -- How to conduct a comprehensive literature search -- Guide to planning a randomized trial -- Guide to planning a nonrandomized study -- Study sample size -- How to budget for a research study -- Research ethics, review boards, and consent forms -- Regulatory issues in the evaluation of a new device or drug -- Strategies in research funding -- Conducting a research study -- Roles of the research team -- Role of a central methods center -- Role of a data monitoring committee -- Need for separate adjudication of outcomes -- Data management -- Study case report forms -- Study manual of operations -- Review of basic statistical principles -- Statistical means and proportions -- Regression analysis -- Analysis of variance -- Correlation defined.
  • 2012From: Springer
    Rachel L. Richesson, James E. Andrews, editors.
    "This book provides foundational coverage of key areas, concepts, constructs, and approaches of medical informatics as it applies to clinical research activities, in both current settings and in light of emerging policies. The field of clinical research is fully characterized (in terms of study design and overarching business processes), and there is emphasis on information management aspects and informatics implications (including needed activities) within various clinical research environments. The purpose of the book is to provide an overview of clinical research (types), activities, and areas where informatics and IT could fit into various activities and business practices. This book introduces and applies informatics concepts only as they have particular relevance to clinical research settings"--Provided by publisher.
  • 2013From: ProQuest Ebook Central
    R. Jennifer Cavalieri, Mark E. Rupp.
    Introduction to research -- Site administration -- Managing financial processes -- Managing regulatory activities and documents -- Managing clinical trial activities -- Managing data and research records -- Conclusions and final remarks.
  • 2006From: Springer
    edited by David F. Penson, John Wei.
    Planning the research / Eugene Blackstone -- Ethical issues in clinical research / David F. Penson -- Budget development and staffing / Judith Fine and Peter C. Albertsen -- Non randomized interventional study designs (quasi-experimental designs) / David Axelrod, Rodney Hayward -- Randomized clinical trials of surgical procedures / Michael P. Porter -- Use of observational databases (registries) in research / Deborah P. Lubeck -- Risk adjustment / William G. Henderson and Shukri F. Khuri -- Basic statistical methods / David Etzioni, Nadia Howlader, and Ruth Etzioni -- Survival analyses / Rodney L. Dunn and John T. Wei -- Assessing the performance and validity of diagnostic tests and screening programs / David C. Miller, Rodney L. Dunn, and John T. Wei -- Secondary data analyses / Andrew Rosenberg, MaryLou VH Greenfield, and Justin B. Dimick -- Traditional outcome measures / Aruna V. Sarma, and Julie C. McLaughlin -- Health-related quality of life / Mark Litwin -- Measuring patient satisfaction / Arvin Koruthu George and Martin G. Sanda -- Quality of care / Jessica B. O'Connell and Clifford Y. Ko -- Cost-effectiveness analyses / Lynn Stothers -- Qualitative research / Donna L. Berry, Sally L. Maliski, and William J. Ellis -- Systematic reviews and meta-analyses / Timothy J. Wilt and Howard A. Fink.
  • 2011From: CRCnetBASE
    Karl E. Peace, Ding-Geng (Din) Chen.
    "Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Drawing from the authors courses on the subject as well as the first authors more than 30 years working in the pharmaceutical industry, Clinical trial methodology emphasizes the importance of statistical thinking in clinical research and presents the methodology as a key component of clinical research. From ethical issues and sample size considerations to adaptive design procedures and statistical analysis, the book first covers the methodology that spans every clinical trial regardless of the area of application. Crucial to the generic drug industry, bioequivalence clinical trials are then discussed. The authors describe a parallel bioequivalence clinical trial of six formulations incorporating group sequential procedures that permit sample size re-estimation. The final chapters incorporate real-world case studies of clinical trials from the authors own experiences. These examples include a landmark Phase III clinical trial involving the treatment of duodenal ulcers and Phase III clinical trials that contributed to the first drug approved for the treatment of Alzheimers disease. Aided by the U.S. FDA, the U.S. National Institutes of Health, the pharmaceutical industry, and academia, the area of clinical trial methodology has evolved over the last six decades into a scientific discipline. This guide explores the processes essential for developing and conducting a quality clinical trial protocol and providing quality data collection, biostatistical analyses, and a clinical study report, all while maintaining the highest standards of ethics and excellence"--Provided by publisher.
  • 2006From: Springer
    edited by MaryAnn Foote.
  • 2011From: Springer
    Holly H.C. Kimko, Carl C. Peck, editors.
    This edition includes both updates and new uses and issues concerning CTS, along with case studies of how clinical trial simulations are being applied in various therapeutic and application areas. Importantly, the book expands on the utility of CTS for informing decisions during drug development and regulatory review. Each chapter author was selected on the basis of demonstrated expertise in state-of-the-art application of CTS. The target audience for this volume includes researchers and scientists who wish to consider use of simulations in the design, analysis, or regulatory review and guidance of clinical trials. This book does not embrace all aspects of trial design, nor is it intended as a complete recipe for using computers to design trials. Rather, it is an information source that enables the reader to gain understanding of essential background and knowledge for practical applications of simulation for clinical trial design and analysis. It is assumed that the reader has a working understanding of pharmacokinetics and pharmacodynamics, modeling, pharmacometric analyses, and/or the drug development and regulatory processes.
  • 2016From: ClinicalKey
    Tom Brody.
    1. Origins of drugs -- 2. Clinical trial design -- 3. Run-in period -- 4. Inclusion/exclusion criteria, stratification, and subgroups -- part I -- 5. Inclusion/exclusion criteria, stratification, and subgroups -- part II -- 6. Blinding, randomization, and allocation -- 7. Placebo arm as part of clinical trial design -- 8. Intent-to-treat analysis versus per protocol analysis -- 9. Biostatistics -- part I -- 10. Biostatistics -- part II -- 11. Introduction to endpoints -- 12. Oncology endpoint -- objective response -- 13. Oncology endpoints : overall survival and progression-free survival -- 14. Oncology endpoints : time to progression -- 15. Oncology endpoint : disease-free survival -- 16. Oncology endpoint : time to distant metastasis -- 17. Neoadjuvant therapy versus adjuvant therapy -- 18. Hematological cancers -- 19. Biomarkers -- 20. Endpoints for immune diseases -- 21. Endpoints for infections -- 22. Health-related quality of life tools -- oncology -- 23. Health-related quality-of-life tools -- immune disorders -- 24. Health-related quality-of-life tools -- infections -- 25. Drug safety -- 26. Mechanism of action of diseases and drugs -- part I -- 27. Mechanism of action -- part II (cancer) -- 28. Mechanism of action -- part III (immune disorders) -- 29. Mechanisms of action -- part IV (infections) -- 30. Consent forms -- 31. Package inserts -- 32. Warning letters -- 33. Regulatory approval -- 34. Patents.
  • 2012From: ScienceDirect
    Tom Brody.
    The origins of drugs -- Introduction to regulated clinical trials -- Run in period -- Inclusion/exclusion criteria, stratification, and subgroups : part I -- Inclusion and stratification criteria : part II -- Randomization, allocation, and blinding -- Placebo arm as part of clinical study design -- Intent to treat analysis vs. per protocol analysis -- Biostatistics -- Introduction to endpoints for clinical trials in pharmacology -- Endpoints in clinical trials on solid tumors : objective response -- Oncology endpoints : overall survival and progression free survival -- Oncology endpoints : time to progression -- Oncology endpoint : disease free survival -- Oncology endpoint : time to distant metastasis -- Neoadjuvant therapy versus adjuvant therapy -- Hematological cancers -- Biomarkers and personalized medicine -- Endpoints in immune diseases -- Endpoints in clinical trials on infections -- Health related quality of life -- Health related quality of life instruments for immune disorders -- Health related quality of life instruments and infections -- Drug safety -- Mechanism of action : part I -- Mechanism of action, part II : cancer -- Mechanism of action, part III : immune disorders -- Mechanisms of action, part IV : infections -- Consent forms -- Package inserts -- Regulatory approval -- Patents.
  • 2012From: Wiley
    Curtis L. Meinert.
    A thoroughly updated new edition of the essential reference on the design, practice, and analysis of clinical trials. "Clinical trials dictionary : terminology and usage recommendations", Second Edition presents clear, precise, meticulously detailed entries on allaspects of modern-day clinical trials. Written and compiled by one of the world's leading clinical trialists, this comprehensive volume incorporates areas of medicine, statistics, epidemiology, computer science, and bioethics - providing a treasure trove of key terms and ideas.
  • 2013From: Wiley
    Curtis L. Meinert.
  • 2014From: Wiley
    Michael O'Kelly, Bohdana Ratitch.
    "This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included - the reader is given a toolbox for implementing analyses under a variety of assumptions"--Provided by publisher.
  • editors, Julian P.T. Higgins and Sally Green.
    "The Cochrane Handbook for Systematic Reviews of Interventions (the Handbook) provides guidance to authors for the preparation of Cochrane Intervention reviews (including Cochrane Overviews of reviews)." "The Handbook is updated regularly to reflect advances in systematic review methodology and in response to feedback from users. Please refer to the web site for the most recent version, for interim updates to the guidance and for details of previous versions of the Handbook."
  • 2010From: ProQuest Safari
    Glenn A. Walker, Jack Shostak.
    Introduction & basics -- Topics in hypothesis testing -- The data set TRIAL -- The one-sample t-test -- The two-sample t-test -- One-way ANOVA -- Two-way ANOVA -- Repeated measures analysis -- The crossover design -- Linear regression -- Analysis of covariance -- The Wilcoxon signed-rank test -- The Wilcoxon rank-sum test -- The Kruskal-Wallis test -- The binomial test -- The Chi-square test -- Fisher's exact test -- McNemar's test -- The Cochran-Mantel-Haenszel test -- Logistic regression -- The log-rank test -- The Cox proportional hazards model -- Exercises.
    Also available: Print – 2010
  • Maureen M. Dawson, Brian A. Dawson, Joyce A. Overfield.
    PrintStatus: Not Checked OutLane Catalog Record
    Communication skills in science -- Using scientific literature -- Essay writing -- Writing practical reports -- The project report -- Scientific posters -- Oral presentations -- Preparing a curriculum vitae and job application.
  • 2011From: ProQuest Safari
    by Waddy Thompson.
    The Practice of Grant Writing -- The ABCs of Grants -- A Foundation Primer -- A Corporation Primer -- A Government Primer -- An Individual Donor Primer -- You Can Find It Online -- You Can Find It Offline -- Narrowing Your Prospects -- Sow Before You Reap -- Testing the Waters -- Planning for Success, Now and Tomorrow -- The Parts of a Grant Proposal -- Selling Your Project -- Dollars and Cents -- The Cover Letter and Executive Summary -- Repute and Tribute -- Putting It All Together -- Other Types of Applications -- Waiting for and Receiving the Verdict -- Reporting on Success -- Advice for Individual Grant Seekers -- Working as a Freelance Grant Writer -- The Business Side of Freelancing.
  • 2011From: CRCnetBASE
    Shein-Chung Chow.
    "Preface In pharmaceutical/clinical development of a test drug or treatment, relevant clinical data are usually collected from subjects with the diseases under study in order to evaluate safety and efficacy of the test drug or treatment under investigation. To provide accurate and reliable assessment, well-controlled clinical trials under valid study design are necessarily conducted. Clinical trial process is a lengthy and costly process, which is necessary to ensure a fair and reliable assessment of the test treatment under investigation. Clinical trial process consists of protocol development, trial conduct, data collection, statistical analysis/interpretation, and reporting. In practice, controversial issues evitably occur regardless the compliance of good statistical practice (GSP) and good clinical practice (GCP). Controversial issues in clinical trials are referred to as debatable issues that are commonly encountered during the conduct of clinical trials. In practice, controversial issues could be raised from, but are not limited to, (1) compromises between theoretical and real/common practices, (2) miscommunication and/or misunderstanding in perception/interpretation among regulatory agencies, clinical scientists, and biostatisticians, and (3) disagreement, inconsistency, miscommunication/misunderstanding, and errors in clinical practice"--Provided by publisher.
  • 2013From: NAP
    Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences, Board on Health Sciences Policy, Institute of Medicine of The National Academies ; Alan I. Leshner, Sharon F. Terry, Andrea M. Schultz, and Catharyn T. Liverman, editors.
    This report provides the IOM committee's findings and recommendations regarding the progress and potential of NIH's CTSA Program. The report covers the breadth of the statement of task and highlights opportunities to bolster the program and ensure its continued success and sustainability in supporting clinical and translational researchers and serving the needs of the communities CTSAs are linked to and in which they reside. Chapter 2 discusses the ecosystem in which NCATS and the CTSA Program operate and provides the committee's vision for the next phase of the CTSA Program. Chapter 3 emphasizes the need for strong and active leadership by NCATS in establishing a clear vision and mission for the program along with measurable goals; supporting individual CTSAs; partnering and collaborating within the NIH and with external partners; and evaluating and communicating the program's value. Chapter 4 highlights specific opportunities and priorities in the areas of training and education, community engagement, and research related to child health. On the basis of discussions, conclusions, and recommendations outlined in the preceding chapters, in Chapter 5 the report concludes with next steps and potential future directions.
  • 2009From: CRCnetBASE
    Jay Herson.
    Introduction -- Organization of a safety monitoring program for a confirmatory trial -- Meetings -- Clinical issues -- Statistical issues -- Bias and pitfalls -- Data monitoring committee decisions -- Emerging issues.
  • 2006From: Springer
    David L. DeMets, Curt D. Furberg, Lawrence M. Friedman, editors.
    Also available: Print – 2006
  • 2014From: Wiley
    Shein-Chung Chow, Jen-Pei Liu.
    pt. I. Introduction -- Basic statistical concepts -- Basic design considerations -- Randomization and blinding -- pt. II. Designs and their classifications -- Designs for clinical trials -- Designs for cancer clinical trials -- Classification of clinical trials -- pt. III. Analysis of clinical data -- Analysis of continuous data -- Analysis of categorical data -- Censored data and interim analysis -- Sample size determination -- pt. IV. Issues in evaluation -- Issues in efficacy evaluation -- Safety assessment -- pt. V. Recent development -- Biomarkers and targeted clinical trials -- Trials for evaluating accuracy of diagnostic devices -- Statistical methods in translational medicine -- Adaptive clinical trial designs -- Traditional Chinese medicine -- pt. VI. Conduct of clinical trials -- Preparation and implementation of a clinical protocol -- Data management of a clinical trial.
  • 2009From: CRCnetBASE
    edited by Karl E. Peace.
    Overview of time-to-event endpoint methodology / Karl E. Peace -- Design (and monitoring) of clinical trials with time-to-event endpoints / Michael W. Sill and Larry Rubinstein -- Overview of time-to-event parametric methods / Karl E. Peace and Kao-Tai Tsai -- Overview of semiparametric inferential methods for time-to-event endpoints / Jianween Cai and Donglin Zeng -- Overview of inferential methods for categorical time-to-event data / Eric V. Slud -- Overview of Bayesian inferential methods including time-to-event endpoints / Laura H. Gunn -- An efficient alternative to the Cox model for small time-to-event trials / Devan V. Mehrotra and Arthur J. Roth -- Estimation and testing for change in hazard for time-to-event endpoints / Rafia Bhore and Mohammad Huque -- Overview of descriptive and graphical methods for time-to-event data / Michael O'Connell and Bob Treder -- Design and analysis of analgesic trials / Akiko Okamoto, Julia Wang, and Surya Mohanty -- Design and analysis of analgesic trials with paired time-to-event endpoints / Zhu Wang and Hon Keung Tony Ng -- Time-to-event endpoint methods in antibiotic trials / Karl E. Peace -- Design and analysis of cardiovascular prevention trials / Michelle McNabb and Andreas Sashegyi -- Design and analysis of antiviral trials / Anthony C. Segreti and Lynn P. Dix -- Cure rate models with applications to melanoma and prostate cancer data / Ming-Hui Chen and Sungduk Kim -- Parametric likelihoods for multiple nonfatal competing risks and death, with application to cancer data / Peter F. Thall and Xuemei Wang -- Design, summarization, analysis, and interpretation of cancer prevention trials / Matthew C. Somerville, Jennifer B. Shannon, and Timothy H. Wilson -- LASSO method in variable selection for right-censored time-to-event data with application to astrocytoma brain tumor and chronic myelogonous leukemia / Lili Yu and Dennis Pearl -- Selecting optimal treatments based on predictive factors / Eric C. Polley and Mark J. van der Laan -- Application of time-to-event methods in the assessment of safety in clinical trials / Kelly L. Moore and Mark J. van der Laan -- Design and analysis of chronic carcinogenicity studies of pharmaceuticals in rodents / Mohammad Atiar Rahman and Karl K. Lin -- Design and analysis of time-to-tumor response in animal studies : a Bayesian perspective / Steve Thomson and Karl K. Lin.
  • 2012From: Wiley
    Gerald van Belle, Kathleen F. Kerr.
    Design and Analysis of Experiments in the Health Sciences; Contents; Preface; 1 The Basics; 1.1 Four Basic Questions; 1.2 Variation; 1.3 Principles of Design and Analysis; 1.4 Experiments and Observational Studies; 1.5 Illustrative Applications of Principles; 1.6 Experiments in the Health Sciences; 1.7 Adaptive Allocation; 1.7.1 Equidistribution; 1.7.2 Adaptive Allocation Techniques; 1.8 Sample Size Calculations; 1.9 Statistical Models for the Data; 1.10 Analysis and Presentation; 1.10.1 Graph the Data in Several Ways; 1.10.2 Assess Assumptions of the Statistical Model.
  • 2010From: CRCnetBASE
    Diane L. Fairclough.
    Using SAS, SPSS, and R, this book addresses design and analysis aspects in enough detail so that readers can apply statistical methods to their own longitudinal studies. This edition includes a new chapter on testing models that involve moderation and mediation, a new chapter on QALYs and QTWiST specific to clinical trials, and recent methodological developments for the analysis of trials with missing data. It also presents revised discussions of multiple comparisons procedures that focus on the integration of HRQoL outcomes with other study outcomes using gatekeeper strategies.
  • John W. Creswell, Vicki L. Plano Clark.
    "Combining the latest thinking about mixed methods research designs with practical, step-by-step guidance, the Second Edition of Designing and Conducting Mixed Methods Research now covers six major mixed methods designs. Authors John W. Creswell and Vicki L. Plano Clark walk readers through the entire research process, from formulating questions to designing, collecting data, and interpreting results and include updated examples from published mixed methods studies drawn from the social, behavioral, health, and education disciplines."--pub. desc.
  • 2007From: Ovid
    [edited by] Stephen B. Hulley ... [et al.].
    Designing a randomized blinded trial / Steven R. Cummings, Deborah Grady, and Stephen B. Hulley -- Alternative trial designs and implementation issues / Deborah Grady, Steven R. Cummings, and Stephen B. Hulley -- Designing studies of medical tests / Thomas B. Newman ... [et al.] -- Utilizing existing databases / Deborah Grady and Norman Hearst -- Addressing ethical issues / Bernard Lo -- Designing questionnaires and interviews / Steven R. Cummings and Stephen B. Hulley -- Data management / Michael A. Kohn -- Implementing the study and quality control / Deborah Grady and Stephen B. Hulley -- Community and international studies / Norman Hearst and Thomas E. Novotny -- Writing and funding a research proposal / Steven R. Cummings and Stephen B. Hulley. Getting started: the anatomy and physiology of clinical research / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Conceiving the research question / Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley -- Choosing the study subjects: specification, sampling, and recruitment / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Planning the measurements: precision and accuracy / Stephen B. Hulley, Jeffrey N. Martin and Steven R. Cummings -- Getting ready to estimate sample size: hypotheses and underlying principles / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Estimating sample size and power: applications and examples / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Designing a cohort study / Steven R. Cummings, Thomas B. Newman, and Stephen B. Hulley -- Designing cross-sectional and case-control studies / Thomas B. Newman ... [et al.] -- Enhancing causal inference in observational studies / Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley --
    Also available: Print – 2007
  • 2012From: Springer
    David Harrington, editor.
  • 2006From: NAP
    Committee on Clinical Trial Registries, Board on Health Sciences Policy.
  • 1999From: Wiley
    Simon Day.
  • edited by Errol C. Friedberg and Philip C. Hanawalt.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008From: Springer
    edited by Pranee Liamputtong.
  • 2011From: CRCnetBASE
    Ying Kuen Cheung.
    Part I. Fundamentals -- Chapter 1. Introduction -- Chapter 2. Dose Finding in Clinical Trials -- Chapter 3. The Continual Reassessment Method -- Chapter 4. One-Parameter Dose-Toxicity Models -- Chapter 5. Theoretical Properties -- Chapter 6. Empirical Properties -- Part II. Design Calibration -- Chapter 7. Specifications of a CRM Design -- Chapter 8. Initial Guesses of Toxicity Probabilities -- Chapter 9. Least Informative Normal Prior -- Chapter 10. Initial Design -- Part III. CRM and Beyond -- Chapter 11. The Time-to-Event CRM -- Chapter 12. CRM with Multiparameter Models -- Chapter 13. When the CRM Fails -- Chapter 14. Stochastic Approximation.
  • 2010From: Karger
    editors, Berthold Koletzko, Sibylle Koletzko, Frank Rümmele.
    Innovations in infant milk feeding : from the past to the future / Koletzko, B. -- Novel insights into human lactation as a driver of infant formula development / Lønnerdal, B. -- The clinical challenge of preventing and treating malnutrition / Cooper, P.A. -- Progress of enteral feeding practice over time : moving from energy supply to patient-and disease-adapted formulationse / Koletzko, S. -- Molecular mechanisms of pediatric nutrition / Rümmele, F. -- Epidemiological research drives a paradigm shift in complementary feeding : the celiac disease story and lessons learnt / Nordyke, K. ... [et al.] -- Technological progress as a driver of innovation in infant foods / Ferruzzi, M.G.; Neilson, A.P. -- Health economic perspectives of pediatric malnutrition : determinants of innovative progress / Spieldenner, J. -- Economic perspectives on pediatric obesity : impact on health care expenditures and cost-effectiveness of preventive interventions / John, J. -- Sustainable clinical research, health economic aspects, and marketing : drivers of product innovation / Haschke, F.; Klassen-Wigger, P. -- Evaluation of dietetic product innovations : the relative role of preclinical and clinical studies / Makrides, M.; Gibson, R.A. -- Regulatory environment and claims : limits and opportunities / Martin, A. -- The role of consumers / Raats, M.M. -- Bioethics and innovation in pediatric nutrition research / Solomons, N.W. -- The role of pediatricians as innovators in pediatric nutrition / Greer, F.R. -- Promoting innovation in pediatric nutrition / Bier, D.M.
  • 2005From: Springer
    edited by Berthold Koletzko, Peter Dodds, Hans Akerblom and Margaret Ashwell.
    What is the EU infant nutrition cluster? -- Early nutrition and its later consequences: new opportunities -- The developmental origins of adult health and well-being -- Long term effects of breastfeeding on the infant and mother -- Experimental evidence for long-term programming effects of early diet -- Candidate genes for obesity--how might they interact with environment and diet? -- Rate of growth in early life: a predictor of later health? -- Protective effect of breast-feeding against obesity in childhood-- Discussion forum: from innovation to implementation -- Challenges and opportunities in pan-European collaboration for researchers from Central and Eastern Europe -- Best practice in communicating the results of European research to the public -- Longterm effects of pre- and postnatal exposure to low and high dietary protein levels / Cornelia C. Metges -- Protein intake in the first year of life: a risk factor for later obesity? -- The role of long-chain poly-unsaturated fatty acids (LCPUFA) in growth and development -- Experimental models for studying perinatal lipid metabolism -- Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial -- Young researchers' workshop -- Consumer needs regarding dietetic products for pregnant and lactating women and for baby foods -- Focus group: breakfast meeting: SMES and their co-operation with academia -- Ethical issues in perinatal nutrition research -- Early programming of diabetes risk--an introduction -- Early nutrition and later diabetes risk -- Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin? -- Gluten-free diet in subjects at risk for type 1 diabetes: a tool for delaying progression to clinical disease? -- Insulin like growth factor regulation of body mass in breastfed and milk formula fed infants -- Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in erythrocyte membrane lipids in pregnant women -- Comparison of essential fatty acid status among German, Hungarian and Spanish women at mid-gestation -- Trans isomeric fatty acids as confounding variables in studies on perinatal LC-PUFA supply -- An eight years prospective study of iron deficiency anaemia in infancy -- New insights in the potential mechanism of action of nucleotides to modulate immunity -- Thriving of malnourished breastfed infants after additional formula milk feeding -- Role of mammary gland lipoprotein lipase in the availablilty of polyunsaturated fatty acids for milk synthesis -- Is the crying behaviour in infants up to the age of 3 months influenced by the type of early nutrition? -- Dietary gangliosides: beneficial effects for the neonate and potential mechanism of action -- Leptin in breast-fed and formula-fed infants -- Dietary fatty acids during pregnancy determines maternal fatty acid profile during late pregnancy and their availability to the fetus even during fasting condtions -- Effects of oil-supplemented diets on liver expression of PPAR alpha-related genes in pregnant rats -- Effect of a new infant formula enriched with prebiotics, probiotics, nucleotides and LC-PuFA on recovery after infection -- Does habitual protein intake in early childhood influence age and body mass index at adiposity rebound? -- Dietary compliance in diabetes prevention project in Finland -- Changes of plasma fatty acid profile and antioxidant vitamins during normal pregnancy -- Optimal design for the recruitment of participants as a factor for the effective implementation of a clinical trial -- The effect of ponderal index on plasma concentration of insulin-like growth factor-1 (IGF-1) in neonatal pigs -- Effects of prenatal exposure to low and high dietary protein levels on maternal and fetal amino acid metabolism in rats -- Cow's milk introduction in Spanish infants -- Longer term effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids: a randomized clinical trial -- Patterns of growth and energy utilization of the diet after a period of dietary restriction during the weaning period -- Infant formula feeding pattern and weaning introduction in Spanish infants -- Visual evoked potentials in infants after dietary supply of docosahexaenoic acid and 5-methyltetrahydrofolate during pregnancy -- Electronic data capture and use of internet technologies in a double-blind randomised intervention trial -- Breastfeeding and baby friendly hospital initiative in Slovenia -- Nutritional status in young adults with screen-detected silent/sub-clinical coeliac disease -- Liporotein lipase (LPL) MRNA expression in placentas from normal and IUGR (intrauterine growth restricted) pregnancies by real-time PCR -- Maternal fasting effect on neonatal health -- The quality of schoolchildren's nutrition in Serbia -- Tendency towards obesity in Sydney school children -- Monitoring and supervising a dietary intervention trial using modern data processing system -- Analysis of drop-outs in a longitudinal study -- Recruitment strategies of the Spanish group in the "EU childhood obesity: programming by infant nutrition" -- Diet and nutritional risk factors in schoolchildren -- Influence of two forms of caseinophosphopeptide on iron bio availability -- Model of childhood obesity primary prevention programme -- Problems related to recruitment of participants for the triger project -- Vitamin D status at birth in Brussels--preliminary results -- Obesity among young adolescent Kuwaitis -- Dynamic changes in adiposity from fetal to postnatal life are involved in the adult metabolic syndrome associated with reduced fetal growth -- Excess fetal adiposity is associated with programming of placental lipid genes -- Appetite control in breastfed and formula fed infants -- What are the Danone Institutes.
    Also available: Print – 2005
  • 2009From: Springer
    Paul Smeyers, Marc Depaepe, editors.
  • sous la direction de Jean-Gaël Barbara & Pierre Corvol.
  • Catherine Brady.
    PrintStatus: Not Checked OutLane Catalog Record
    A certain sense of self -- Shedding encumbrances -- One of Gall's gals -- Revelations -- Opportunism -- Gold rush -- Entering the fray -- An interlocking system -- Dr. Jekyll or Mr. Hyde? -- Members of a guild -- Citizen scientist -- Political fallout -- "You have to think it's fun" -- Notes -- Bibliography.
  • 2009From: Springer
    Ramón Ribes, Palma Iannarelli, Rafael F. Duarte.
  • 2012From: Springer
    O.S. Miettinen, I. Karp.
    Epidemiology: Grappling with the Concept -- Epidemiological Knowledge: Examples -- Etiology as a Pragmatic Concern -- Etiology as the Object of Study -- Etiologic Studies' Essentials -- Etiologic Studies' Typology -- Etiologic Studies' Objects Design -- Etiologic Studies' Methods Design -- Etiologic Studies' Intervention Counterparts -- Causal Studies' Acausal Counterparts -- Studies on Screening for a Cancer -- Some Paradigmatic Studies -- From Studies to Knowledge -- Fact-finding in Epidemiological Practice.
  • 2013From: Wiley
    editor, Phil Langton.
    This concise, easy-to-follow text gives an insight into core techniques and practices in biomedical research and how, when and why a technique should be used and presented in the literature. Readers are alerted to common failures and misinterpretations that may evade peer review and are equipped with the judgment necessary to be properly critical of the findings claimed by research articles. --from publisher description
  • 2014From: Springer
    Stephen P. Glasser, editor.
    In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.
  • 2008From: Springer
    edited by Stephen P. Glasser.
    I. pt. I. Clinical Research: Definitions, "Anatomy and Physiology," and the Quest for "Universal Truth" / Stephen P. Glasser, p. 3-11 -- Introduction to Clinical Research and Study Designs / Stephen P. Glasser, p. 13-27 -- Clinical Trials / Stephen P. Glasser, p. 29-62 -- Alternative Interventional Study Designs / Stephen P. Glasser, p. 63-71 -- Postmarketing Research / Stephen P. Glasser, Elizabeth Delzell and Maribel Salas, p. 73-91 -- The United States Federal Drug Administration (FDA) and Clinical Research / Stephen P. Glasser, Carol M. Ashton and Nelda P. Wray, p. 73-110 -- The Placebo and Nocebo Effect / Stephen P. Glasser and William Frishman, p. 111-140 -- Recruitment and Retention / Stephen P. Glasser, p. 141-149 -- Data Safety and Monitoring Boards (DSMBs) / Stephen P. Glasser and O. Dale Williams, p. 151-158 -- Meta-Analysis / Stephen P. Glasser and Sue Duval, p. 159-177 -- II. pt. II. -- Research Methods for Genetic Studies / Sadeep Shrestha and Donna K. Arnett, p. 181-199 -- Research Methods for Pharmacoepidemiology Studies / Maribel Salas and Bruno Stricker, p. 201-216 -- Implementation Research: Beyond the Traditional Randomized Controlled Trial / Amanda H. Salanitro, Carlos A. Estrada and Jeroan J. Allison, p. 217-244 -- Research Methodology for Studies of Diagnostic Tests / Stephen P. Glasser, p. 245-257 -- III. pt. III. Statistical Power and Sample Size: Some Fundamentals for Clinician Researchers / J. Michael Oakes, p. 261-278 -- Association, Cause, and Correlation / Stephen P. Glasser and Gary Cutter, p. 279-294 -- Bias, Confounding, and Effect Modification / Stephen P. Glasser , p. 295-302 -- It's All About Uncertainty / Stephen P. Glasser and George Howard, p. 303-316 -- Grant Writing / Donna K. Arnett and Stephen P. Glasser, p. 317-325 -- IV. pt. IV. The Media and Clinical Research / Stephen P. Glasser, p. 329-333 -- Mentoring and Advising / Stephen P. Glasser and Edward W. Hook, p. 335-340 -- Presentation Skills: How to Present Research Results / Stephen P. Glasser, p. 341-349.
  • 2011From: Stanford Law School
    In response to a request by President Barak Obama on November 24, 2010, the Presidential Commission for the Study of Bioethical Issues oversaw a thorough fact-finding investigation into the specifics of the U.S. Public Health Service-led studies in Guatemala involving the intentional exposure and infection of vulnerable populations. Following a nine-month intensive investigation, the Commission has concluded that the Guatemala experiments involved gross violations of ethics as judged against both the standards of today and the researchers' own understanding of applicable contemporaneous practices. It is the Commission's firm belief that many of the actions undertaken in Guatemala were especially egregious moral wrongs because many of the individuals involved held positions of public institutional responsibility. The best thing we can do as a country when faced with a dark chapter is to bring it to light. The Commission has worked hard to provide an unvarnished ethical analysis to both honor the victims and make sure events such as these never happen again.
  • 2007From: Springer
    Bengt D. Furbert and Curt D. Furberg.
    Also available: Print – 2007
  • 2012From: Springer
    Pedro J. Gutiérrez Diez, Irma H. Russo, Jose Russo.
    Historical Introduction -- Descriptive Biostatistics -- Inferential Biostatistics (I): Estimating Values of Biomedical Magnitudes -- Inferential Biostatistics (II): Estimating Biomedical Behaviors -- Equations: Formulating Biomedical Laws and Biomedical Magnitudes -- Systems of Equations: The Explanation of Biomedical Phenomena (I). Basic Questions -- Systems of Equations: The Explanation of Biomedical Phenomena (II). Dynamic Interdependencies -- Optimal Control Theory: From Knowledge to Control (I). Basic Concepts -- Optimal Control Theory: From Knowledge to Control (II). Biomedical Applications -- Game Theory.
  • Jonathan Orsay.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014From: Thieme-Connect
    Hamish Simpson, Peter Augat.
  • [produced for the Sherman Fairchild Foundation by Stanford University School of Medicine].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006From: ProQuest Ebook Central
    edited by Deborah Blum, Mary Knudson, Robin Marantz Henig.
    pt. 1: Learning the craft / Mary Knudson -- Finding story ideas and sources / Philip M. Yam -- Reporting from science journals / Tom Siegfried -- Understanding and using statistics / Lewis Cope -- Writing well about science: techniques from teachers of science writing -- Taking your story to the next level / Nancy Shute -- Finding a voice and a style / David Everett -- pt. 2: Choosing your market / Carey Goldberg -- Small newspapers / Ron Seely -- Large newspapers / Robert Lee Hotz -- Popular magazines / Janice Hopkins Tanne -- Trade and science journals / Colin Norman -- Broadcast science journalism / Joe Palca -- Freelance writing / Kathryn Brown -- Science books / Carl Zimmer -- Popular audiences on the web / Alan Boyle -- Science audiences on the web / Tabitha Powledge -- Science editing / Mariette DiChristina -- pt. 3: Varying your writing style / Robin Marantz Henig -- Deadline writing / Gareth Cook -- Investigative reporting / Antonio Regalado -- Gee whiz science writing / Robert Kunzig -- Explanatory writing / George Johnson -- Narrative writing / James Shreeve -- The science essay / Robert Kanigel -- pt. 4: Covering stories in the life sciences / Deborah Blum -- Medicine / Shannon Brownlee -- Infectious diseases / Marilyn Chase -- Nutrition / Sally Squires -- Mental health / Paul Raeburn -- The biology of behavior / Kevin Begos -- Human genetics / Antonio Regalado -- pt. 5: Covering stories in the physical and environmental sciences / Deborah Blum -- Technology and engineering / Kenneth Chang -- Space science / Michael D. Lemonick -- The environment / Andrew C. Revkin -- Nature / McKay Jenkins -- Earth sciences / Glennda Chui -- Climate / Usha Lee McFarling -- Risk reporting / Cristine Russell -- Taking a different path: journalists and public information officers / the editors -- pt. 6: Communicating science from institutions / John D. Toon -- Universities / Earle Holland -- Institutional communications during crisis / Joann Ellison Rodgers -- Government agencies / Colleen Henrichsen -- Nonprofits / Frank Blanchard -- Museums / Mary Miller -- Corporate public relations / Marion Glick -- Epilogue / James Gleick.
  • 2011From: CRCnetBASE
    Andreas Wienke.
    The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. In its simplest form, frailty is an unobserved random proportionality factor that modifies the hazard function of an individual or a group of related individuals. Frailty Models in Survival Analysis presents a comprehensive overview of the fundamental approaches in the area of frailty models. The book extensively explores how univariate frailty models can represent unobserved heterogeneity. It also emphasizes correlated frailty models as extensions of univariate and shared frailty models. The author analyzes similarities and differences between frailty and copula models; discusses problems related to frailty models, such as tests for homogeneity; and describes parametric and semiparametric models using both frequentist and Bayesian approaches. He also shows how to apply the models to real data using the statistical packages of R, SAS, and Stata. The appendix provides the technical mathematical results used throughout. Written in nontechnical terms accessible to nonspecialists, this book explains the basic ideas in frailty modeling and statistical techniques, with a focus on real-world data application and interpretation of the results. By applying several models to the same data, it allows for the comparison of their advantages and limitations under varying model assumptions. The book also employs simulations to analyze the finite sample size performance of the models.--From the publisher's website.
  • 2009From: Springer
    Michael Jay Katz.
  • 2007From: Springer
    Antonella Bacchieri, Giovanni Della Cioppa.
  • 2010From: Springer
    Lawrence M. Friedman, Curt D. Furberg, David L. DeMets.
    Introduction to Clinical Trials -- Ethical Issues -- What Is the Question? -- Study Population -- Basic Study Design -- The Randomization Process -- Blindness -- Sample Size -- Baseline Assessment -- Recruitment of Study Participants -- Data Collection and Quality Control -- Assessing and Reporting Adverse Events -- Assessment of Health-Related Quality of Life -- Participant Adherence -- Survival Analysis -- Monitoring Response Variables -- Issues in Data Analysis -- Closeout -- Reporting and Interpreting of Results -- Multicenter Trials.
    Also available: Print – 2010
  • Emily Ann Cox.
    This dissertation explores the impact of different types of investors on invention and innovation in new firms. While prior work has focused primarily on one type of investor, venture capitalists, and has investigated a few long-term outcomes such as exit events, I compare a variety of investor types and consider more immediate innovation-related goals. Drawing from agency and resource dependence theories, I develop and test hypotheses linking different investor types to invention and innovation in new firms. To do this, I construct a novel longitudinal dataset of 198 U.S.-based minimally invasive surgical device firms between 1986 and 2007. The findings indicate that investor type matters for both invention and innovation. Technology-focused investors promote invention while commercially-focused investors are more beneficial to innovation. I also find that although some investors (VCs) help innovation, other investors (the government's SBIR program) hurt it. This difference can be traced to investors' use of monitoring to tailor resources to the specific needs of new firms. These findings suggest that monitoring can be mutually beneficial to both parties as it allows investors to focus their efforts and new firms to receive needed resources at opportune times. My findings also suggest that new firms should be cautious, as there is a potential dark side to the relationships they form with investors: obtaining resources from some investors may prevent new firms from accomplishing their goals.
  • 2009From: CRCnetBASE
    Hinrich Göhlmann, Willem Talloen.
    "Gene expression studies merge three disciplines with different historical backgrounds: molecular biology, bioinformatics, and biostatistics. This book tears down the omnipresent language barriers among researchers of these different backgrounds by explaining the entire process of a gene expression study from conception to interpretation. It covers important technical and statistical pitfalls and problems, helping not only to explain concepts outside the domain of researchers, but to provide additional guidance in their field of expertise. The book also describes technical and statistical methods conceptually with illustrative examples, enabling those inexperienced with gene expression studies to grasp the basic principles"--Provided by publisher.
  • 2014From: Oxford Medicine Online
    Ian M. MacFarlane, Patricia McCarthy Veach, Bonnie S. LeRoy.
    Developing research questions -- Finding sources -- Writing a review of literature -- Ethics in research -- Choosing a paradigm -- Designing a quantitative study -- Quantitative data analysis : I've got data, how do I get answers? -- Conducting qualitative genetic counseling research -- Preparing a manuscript for publication -- Guidelines for directing research.
  • 2011From: Thieme Book
    edited by Mohit Bhandari, Anders Joensson.
    Why should we publish papers? / George M. Kontakis, Peter V. Giannoudis -- Presented but never published : why research papers are not being published / Cheryl Wylie, Sheila Sprague -- What is the quality of the published orthopaedic literature? / Daniel Vena, Sheila Sprague -- Common pitfalls in the reporting of surgical results / Rudolf W. Poolman -- Overview : what to consider before you start writing / Paul Karanicolas -- Ethics in writing : maintaining credibility / Lyndsay Somerville, Dianne Bryant -- Authorship : what you should know / Rad Zdero, Emil H. Schemitsch -- When do you need a statistician? : more than just number crunchers / Jason W. Busse -- The structured abstract / Ole Brink, Lars C. Borris -- Writing an introduction / Emil H. Schemitsch, Rad Zdero -- Writing a methods section / Emil H. Schemitsch, Rad Zdero -- Results : basics of analysis / Paul Karanicolas -- Results : tables, figures, and appendices / Jacquelyn Marsh, Dianne Bryant -- How to frame a discussion / Kyle Jeray, Stephanie Tanner -- Referencing and acknowledgments / Richard Gould, Bradley Petrisor -- Author instructions / George Mathew, Sheila Sprague -- Formatting your paper : title page and more / Scott Wingerter -- Grammar police : the dos and don'ts of writing / Eric Morrison -- How to address reviewer's comments : dos and don'ts / Rad Zdero, Emil H. Schemitsch -- Getting your research accepted at scientific meetings : writing the abstract / George Mathew, Sheila Sprague -- PowerPoint presentations : tips for presenting your work / Tara M. Mastracci -- Poster presentations : preparing an effective research poster / Chad Coles -- Be consistent : present and publish the same results / Boris A. Zelle.
  • 2011From: ScienceDirect
    Richard Chin, Menghis Bairu [editors].
  • 2006From: Springer
    by Maurice Kogan, Mary Henkel and Steve Hanney.
  • PrintStatus: Not Checked OutLane Catalog Record
  • Stephen W. Russell, DVM, PhD, David C. Morrison, PhD.
    Before you begin to write overview. Finding NIH funding opportunities and responding to them; How to develop an irresistible idea for your grant application; How to find the appropriate program and grant application; How to find the appropriate program and grant mechanism for your idea; Influence of the NIH review process on writing for success; Response to prior review; Create a writng schedule; The template for your research plan overview. Specific aims section: Conceptual framework for creating a bulleted outline; Writing the specific aims section; Development of the rest of your application overview. Strategic use of literature review and preliminary results; Bibliography & References cited section; Research strategy section: Significance (including scientific premise) and innovation subsections; Research strategy section: Approach subsection (Including Rigor, potential biological variables, technical preliminary studies, and renewal progress report); Senior/key person profile(s) form, biographical sketches, and multiple PD/PI leadership plan of the PHS 398 research plan form; PHS 398 modular budget form and budget justifications; SF 424 R & R [breakout] budget form and R & R subaward budget attachment(s) form; Project/performance site location(s) form; Facilities & other resources, equipment, environment impact, historical places, and foreign components sections of the R & R other project information form; Human subjects section, Vertebrate animals, select agent research, consortium/contrctual arrangements, resource sharing plan(s), Authentication of key biological and/or chemical resources, and appendix sections of the PHS 398 research plan form; SF 424 (R & R) [cover] form, the PHS 398 cover page supplement form, and the PHS assignment request form; Maximizing your application's competitiveness; How to create a compelling, informative title for your proposal; Project summary/abstract, project narrative, and proprietary/privileged information; Cover letter attachment and letters of support; Pre-supmission review and subbmission of your application; allowability of post-submission materials.
  • edited by Adele E. Clarke and Kathy Charmaz.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. History, essential and debates in grounded theory -- v. 2. Grounded theory in disciplines and research -- v. 3. Grounded theory exemplars across disciplines -- v. 4. Situational analysis : essentials and exemplars.
  • 2012From: Springer
    Otto O. Yang.
    Overview: overall goals when writing grant applications -- Organization and use of this guide -- Preparing to write -- Types of NIH grants -- Anatomy of the NIH grant application -- Starting to write: planning the aims and overcoming writer's block -- Organization and writing style -- Figures and tables -- Specific aims -- Research strategy: significance -- Research strategy: innovation -- Research strategy: approach -- Bibliography and references cited -- Use of appendices -- Collaborators and consultants -- Training and career development grants -- Administrative sections and submission process -- Scoring process -- Resubmitting an application -- Non-NIH grants -- Conclusions.
  • 2006From: Springer
    edited by Zili Sloboda and William J. Bukoski.
    I: HISTORICAL OVERVIEW: The emerging science of drug abuse prevention / William J. Bukoski -- II: SOCIAL CONTEXTS OF PREVENTION: Effective mass media strategies for drug abuse prevention campaigns / Philip Palmgreen and Lewis Donohew -- Drug abuse prevention curricula in schools / Gilbert J. Botvin and Kenneth W. Griffin -- Dissemination of research-based family intervention for the prevention of substance abuse / Karol L. Kumpfer and Steve Adler -- Peers and the prevention of adolescent drug use -- / E. R. Oetting and R. S. Lynch -- Mobilizing communities to reduce risk for drug abuse: a comparison of two strategies / Michael W. Arthur, Charles D. Ayers, Kelly A. Graham, and J. David Hawkins -- Community-focused drug abuse prevention / Barry M. Kibel and Harold D.Holder -- Drug abuse prevention in the workplace / Royer F. Cook -- Prevention approaches to methadone treatment settings: children of drug abuse treatment clients / Richard F. Catalano, Kevin P. Haggerty, and Randy R. Gainey -- III: PREVENTION AS SOCIAL CONTROL: Drug tests in prevention research / Robert L. DuPont and Keith E. Saylor -- Anti-drug-abuse policies on prevention strategies / Mary Ann Pentz -- IV: THEORETICAL AND EMPIRICAL FOUNDATIONS OF PREVENTION: Forging a relationship between drug abuse epidemiology and drug abuse prevention / Zili Sloboda -- Risk and protective factors of adolescent drug use: implications for prevention programs / Judith S. Brook. David W. Brook, Linda Richter, and Martin Whiteman -- Bridging the gap between substance use prevention theory and practice / Brian R. Flay and John Petraitis -- Preventive intervention targeting precursors / John E. Lochman -- Designing prevention programs: the developmental perspective / Marvin W. Berkowitz and Audrey L. Begun -- V: SPECIAL POPULATIONS: Gender issues in substance abuse prevention / Louise Ann Rohrbach and Joel Milam -- Preventing substance use among Latino youth / Charles R. Martinez, Jr., J. Mark Eddy, and David S. DeGarmo -- African-American substance use epidemiology and prevention issues / William L. Turner and Michael J. Hench -- The effectiveness of alcohol and drug abuse prevention among American-Indian youth / Fred Beauvais and Joseph E. Trimble -- Drug abuse prevention research for Asian and Pacific Islander Americans / W. William Chen -- VI: INTERACTIONS BETWEEN BIOLOGY AND SOCIAL CONTEXT: RISKS FOR MULTIPLE BEHAVIORAL AND MENTAL DISORDERS: Basic science and drug abuse prevention: neuroscience, learning, and personality perspectives / Michael T. Bardo, Thomas Kelly, Donald R. Lynam, and Richard Milich -- Cross-national comparisons of co-morbidities between substance use disorders and mental disorders / Ronald C. Kessler, Sergio Aguilar-Gaxiola, Laura Andrade, Rob Bijl ... [et al.] -- Drug abuse research for high-risk youth / Leona L. Eggert and Brooke P. Randell -- Research designs for family studies / Michael Vanyukov, Howard Moss, and Ralph E. Tarter -- VII: RESEARCH DESIGN, MEASUREMENT, AND DATA ANALYTIC ISSUES: Design principles and their application in preventive field trials / C. Hendricks Brown -- Major data analysis issues in drug abuse prevention research / David P. MacKinnon and James H. Dwyer -- Metholological considerations to prevention research / Linda M. Collins and Brian P. Flaherty -- Prevention program implementation / Steven Schinke and Kristin Cole -- Family management practices: research design and measurement issues / Thomas J. Dishion, Bert Burraston, and Fuzhong Li -- Power analysis models and methods: a latent variable framework for power estimation and analysis / Terry E. Duncan, Susan C. Duncan, and Puzhong Li -- VIII: DRUG ABUSE PREVENTION: A LOOK TO THE FUTURE: Application of computer technology to drug abuse prevention / Kris Bosworth -- Putting science into practice / Gale Held.
  • 2014From: CRCnetBASE
    edited by Carolyn D. Berdanier, Johanna T. Dwyer, David Heber.
    "Beginning with an overview of food and food constituents, the book outlines current nutrient analysis systems, techniques for data analysis, and food labeling. The book reviews nutrition science including terminology, biochemistry, nutrient-nutrient interactions, and comparative nutrition. There is a detailed assessment in section three on nutritional needs throughout the lifecycle. It highlights exercise and the value of vegetarian diets in health promotion and disease prevention. Section four considers issues surrounding nutritional assessment, screening, and monitoring tools including questionnaires, and anthropometric-, psychological-, and energy-assessments--Provided by publisher.
  • 2012From: Springer
    Sandra L. Christenson, Amy L. Reschly, Cathy Wylie, editors.
    pt. 1. What is student engagement? -- pt. 2. Engagement as linked to motivational variables -- pt. 3. Engagement and contextual influences -- pt. 4. Student engagement : determinants and student outcomes -- pt. 5. Measurement issues, instruments, and approaches.
  • 2008From: Springer
    edited by Gertrude Hirsch Hadorn ... [et al.].
  • 2007From: Cambridge
    Roger A. Pielke, Jr.
    Relevant to a wide range of scientific disciplines, this is a practical guide for scientists, politicians and citizens to the relationship between science and politics.
  • 2016From: Thieme
    Markus K. Heinemann, MD, PhD, editor-in-chief.
    Writing a medical paper, or any other scientific text, is full of pitfalls which make it difficult to get it accepted for publication. This unique book gives practical advice on how one can circumvent these dangers. It is richly filled with examples, predominantly negative ones. which exhibit how one should not write a medical paper. This book highlights the fallibilities that manuscripts are often susceptible to, and hence will help writers avoid committing those mistakes. Special Features: Abundant information about a complex subject condensed in a small format Numerous examples from bad man.
  • Trisha Greenhalgh.
    PrintStatus: Not Checked OutLane Catalog Record
    Why read papers at all? -- Searching the literature -- Getting your bearings : what is this paper about? -- Assessing methodological quality -- Statistics for the non-statistician -- Papers that report trials of drug treatments and other simple interventions -- Papers that report trials of complex interventions -- Papers that report diagnostic or screening tests -- Papers that summarise other papers (systematic reviews and meta-analyses) -- Papers that tell you what to do (guidelines) -- Papers that tell you what things cost (economic analyses) -- Papers that go beyond numbers (qualitative research) -- Papers that report questionnaire research -- Papers that report quality improvement case studies -- Getting evidence into practice.
  • 2011From: Springer
    Willo Pequegnat, Ellen Stover, Cheryl Anne Boyce, editors.
    Grantsmanship : necessary but not sufficient strategies for success / Willo Pequegnat -- Community-based collaborations : designing, conducting and sustaining prevention programs / Mary M. McKay, Carl C. Bell, and Clair A. Blake -- Funding opportunity announcements / Jean Noronha -- Selecting the appropriate research mechanism : finding the right match / Cheryl Anne Boyce and Courtney Ferrell Aklin -- Selecting issues and hypotheses for a research proposal / Spero M. Manson -- Electronic submission process / Jean Noronha -- The review process / Anita Miller Sostek -- Common mistakes in proposal writing and how to avoid them / Susan Folkman and Willo Pequegnat -- Reading between the lines of your summary statement / William Lyman, Bonita Stanton, and Willo Pequegnat -- The award process / Ellen Stover -- So you were awarded your grant, now what? / Seth C. Kalichman -- Developing a theoretical framework and rationale for a research proposal / Gregory M. Herek -- How do you formulate a testable exciting hypothesis? / Robyn Dawes -- Qualitative inquiry : an end not just a means / Margaret E. Bentley, Elizabeth E. Tolley, and Willo Pequegnat -- Issues in assessment in research proposals / Helena Chmura Kraemer -- Using technology and the Internet in research / Joseph A. Konstan and William West -- Designing an intervention / Jose Szapocznik, Willo Pequegnat, and Guillermo Prado -- Designing an adequate control group / Thomas J. Coates -- Human subject protection and special population issues / Christine Moretto Wishnoff ... [et al.] -- Animal welfare and behavior / Kevin Quinn and Richard Nakamura -- Developing a resume and presenting your research team / Rayford Kytle and Cheryl Anne Boyce -- Writing the data analysis plan / A.T. Panter -- Developing a budget and financial justification / Masud Rahman -- Developing a quality control/quality assurance program / Lisa C. Strader and Willo Pequegnat -- Applying for training, career development, and early-stage research grants / Donna Mayo -- Cost-effectiveness : a key step in technology transfer / Steven D. Pinkerton and David R. Holtgrave -- Disseminating research findings to service providers and communities / Jeffrey A. Kelly -- Developing a plan for data sharing / Christine Bachrach and Michael Spittel.
  • Robert A. Day and Barbara Gastel.
    PrintStatus: Not Checked OutLane Catalog Record
    What is scientific writing? -- Historical perspectives -- Approaching a writing project -- What is a scientific paper? -- Ethics in scientific publishing -- Where to submit your manuscript -- How to prepare the title -- How to list the authors and addresses -- How to prepare the abstract -- How to write the introduction -- How to write the materials and methods section -- How to write the results -- How to write the discussion -- How to state the acknowledgments -- How to cite the references -- How to design effective tables -- How to prepare effective graphs -- How to prepare effective photographs -- Rights and permissions -- How to submit the manuscript -- The review process (how to deal with editors) -- The publishing process (how to deal with proofs) -- How to write a review paper -- How to write opinion (book reviews, editorials, and letters to the editor) -- How to write a book chapter or a book -- How to write for the public -- How to present a paper orally -- How to prepare a poster -- How to write a conference report -- Use and misuse of English -- Avoiding jargon -- How and when to use abbreviations -- Writing clearly across cultures and media -- How to write science in English as a foreign language -- How to write a thesis -- How to prepare a curriculum vitae -- How to prepare grant proposals and progress reports -- How to write a recommendation letter- and how to ask for one -- How to work with the media -- How to provide peer review -- How to seek a scientific-communication career -- Appendix 1. Selected journal title word abbreviations -- Appendix 2. Words and expressions to avoid -- Appendix 3. Prefixes and abbreviations for SI (système international) units -- Appendix 4. Some helpful websites -- Glossary of technical terms.
  • 2010From: ProQuest Safari
    Natalie Canavor and Claire Meirowitz.
    "This Element is an excerpt from 'The truth about the new rules of business writing' by Natalie Canavor and Claire Meirowitz. How to write successful proposals and grant applications"--Resource description page.
  • 2012From: Springer
    Jan Schildmann...[et al.], editors.
    Part 1. Historical and Socio-Cultural Contexts in Medical Research / British Responses to Nazi Medical War Crimes / Fiona McClenaghan -- History and its Relevance in the Development and Teaching of Research Ethics / Rael D. Strous -- Human Embryo Research and Islamic Bioethics: A View from Iran / Mansooreh Saniei -- From Farming to Pharming: Transcending of Bodily Existence as a Question of Medical Ethics in an Intercultural Context / Axel Siegemund -- Introduction / Jan Schildmann, Verena Sandow, Oliver Rauprich and Jochen Vollmann -- Part 2. Considerations on Ethical and Legal Regulations for Medical Research / Rethinking the Therapeutic Obligation in Clinical Research / Nunziata Comoretto -- Biomedical Research in Developing Countries and International Human Rights Law / Ilja R. Pavone -- Research Involving Human Subjects and Human Biological Material from a European Patent Law Perspective. Autonomy, Commodification, Patentability / Tomasz Zimny -- The Development and Validation of a Guide for Peruvian Research Ethics Committees to Assist in the Review of Ethical-Scientific Aspects of Clinical Trials / Susy Olave Quispe, Duilio Fuentes Delgado, Gabriela Minaya Martínez, Rosa Surco Ibarra and Martín Yagui Moscoso, et al. -- Part 3. Conflicts in Medical Research / Conflicts of Interest in Medical Research: What can Ethics Contribute? / Verena Sandow, Jan Schildmann and Jochen Vollmann -- Research Ethics in Genomics Research: Feedback of Individual Genetic Data to Research Participants / Annelien L. Bredenoord and Johannes J. M. van Delden -- Regulating "Higher Risk, No Direct Benefit" Studies with Children: Challenging the US Federal Regulations / Anna E. Westra, Jan M. Wit, Rám N. Sukhai and Inez D. de Beaufort -- Part 4. New Developments in Medical Research and Ethical Implications / A Paradigm Change in Research Ethics / Rieke van der Graaf and Johannes J. M. van Delden -- Translation of Cancer Molecular Biomarkers: Ethical and Epistemological Issues / Flavio D'Abramo and Cecilia Guastadisegni -- Rethinking the Ethics of Human Biomedical Non-Interventional Research / Kristi L{tilde}ouk.
  • 2014From: WHO
    Also available: Print – 2014
  • 2014From: CRCnetBASE
    edited by Victoria Stodden, Friedrich Leisch, Roger D. Peng.
    Part 1. Tools -- part 2. Practices and guidelines -- part 3. Platforms.
  • editor, Mukta M. Webber ; associate editor, Lea I. Sekely.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Carcinomas of the esophagus and colon.--v. 2. Carcinomas of the liver and pancreas.--v. 3. Carcinomas of the mammary gland, uterus, and skin.--v. 4. Carcinomas of the urinary bladder and kidney.--v. 5. Carcinoma of the prostate and testis.
  • 2007From: ProQuest Ebook Central
    Leon S. Robertson.
    Injury and the role of epidemiology -- Energy characteristics and control strategies -- Research objectives and usable data -- Injury severity -- Injury statistics -- National injury surveillance -- Local injury surveillance -- The use and abuse of causal analysis -- Research designs and data analysis -- Human factors -- Evaluation of programs to change human factors voluntarily -- Evaluation of laws and regulations directed at individual behavior -- Evaluation of agent, vehicle and environmental modifications -- Evaluation of post-injury treatment and rehabilitation -- Injury epidemiology and economics -- Summation of principles.
    Also available: Print – 2007
  • 2000-From: NCBI Bookshelf
    [Institut National de la Santé et de la Recherche Médicale].
    A collection of syntheses of the international scientific literature and recommendations on public health problems, by Inserm's expert advisory groups.
  • 2015From: ScienceDirect
    Ülo Maiväli, University of Tartu, Institute of Technology.
  • 2013From: CRCnetBASE
    edited by Ding-Geng Chen, Jianguo Sun, Karl E. Peace.
    "Preface The aim of this book is to present in a single volume an overview and latest developments in time-to-event interval-censored methods along with application of such methods. The book is divided into three parts. Part I provides an introduction and overview of time-to-event methods for interval-censored data. Methodology is presented in Part II. Applications and related software appear in Part III. Part I consists of two chapters. In Chapter 1, Sun and Li present an overview of recent developments, with attention to nonparametric estimation and comparison of survival functions, regression analysis, analysis of multivariate clustered- and analysis of competing risks interval-censored data. In Chapter 2, Yu and Hsu provide a review of models for interval-censored (IC) data, including: independent interval censorship models, the full likelihood model, various models for C1, C2, and MIC data as well as multivariate IC models. Part II consists of seven chapters (3-9). Chapters 3, 4 and 5 deal with interval-censored methods for current status data. In Chapter 3, Banerjee presents: likelihood based inference, more general forms of interval censoring, competing risks, smoothed estimators, inference on a grid, outcome misclassi- cation, and semiparametric models. In Chapter 4, Zhang presents regression analyses using the proportional hazards model, the proportional odds model, and a linear transformation model, as well as considering bivariate current status data with the proportional odds model. In Chapter 5, Kim, Kim, Nam and Kim develop statistical analysis methods for dependent current status data and utilize the R Package CSD to analyze such data"-- Provided by publisher.
  • edited by J. Dennis Blessing, J. Glenn Forister.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction -- Essays on research in the health professions -- Ethics in research -- Regulatory protection of human subjects in research -- Funding the research : grants -- The research problem -- Review of the literature -- Methodology -- Clinical investigations -- Survey research -- The clinical review -- Qualitative research -- Community-based participatory research -- Data analysis -- Results -- Discussion -- References -- What to do with what you have -- Writing and publishing in the health professions -- Interpreting the literature.
  • 2007From: Springer
    Pentti Rautaharju and Farida Rautaharju.
  • 2009From: Springer
    Ronald R. Gauch.
  • 2012From: Springer
    J. Rick Turner.
  • 2010From: Springer
    Thanos Athanasiou, Haile Debas, Ara Darzi (eds.).
  • 2006From: SAGE
    Michael Bloor and Fiona Wood.
    A practical guide to qualitative techniques for students and researchers across the social and health sciences, this work provides coverage of qualitative methods complemented by extended illustration from the array of academic disciplines in which qualitative research is found and employed.
  • 2008From: Springer
    Oliver Gassmann, Gerrit Reepmeyer, Maximilian von Zedtwitz.
  • 2002From: NAP
    [Panel on IRBs, Surveys and Social Science Research, Cora Marrett, chair].
  • 2014From: WorldScientific
    editors, Rakesh Srivastava, Wojciech Maksymowicz, Wlodek Lopaczynski.
    This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses.
  • S. Lochlann Jain.
    PrintStatus: Not Checked OutLane Catalog Record
    "Cancer can kill: this fact makes it concrete. Still, it's a devious knave. Nearly every American will experience it up-close and all too personally, wondering why the billions of research dollars thrown at the word haven't exterminated it from the English language. Like a sapper diffusing a bomb, Jain unscrambles the emotional, bureaucratic, medical, and scientific tropes that create the thing we call cancer. Scientists debate even the most basic facts about the disease, while endlessly generated, disputed, population data produce the appearance of knowledge. Jain takes the vacuum at the center of cancer seriously and demonstrates the need to understand cancer as a set of relationships--economic, sentimental, medical, personal, ethical, institutional, statistical. Malignant analyzes the peculiar authority of the socio-sexual psychopathologies of body parts; the uneven effects of expertise and power; the potentially cancerous consequences of medical procedures such as IVF; the huge industrial investments that manifest themselves as bone-cold testing rooms; the legal mess of medical malpractice law; and the teeth-grittingly jovial efforts to smear makeup and wigs over the whole messy problem of bodies spiraling into pain and decay. Malignant examines the painful cognitive dissonances produced by the ways a culture that has relished dazzling success in every conceivable arena have twisted one of its staunchest failures into an economic triumph. The intractable foil to American achievement, cancer hands us -- on a silver platter and ready for Jain's incisively original dissection -- our sacrifice to the American Dream"-- Provided by publisher.
  • 2015From: ScienceDirect
    Peter J. Snyder, Linda C. Mayes, William E. Smith.
    The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies.
  • 2014From: Springer
    by Silvia M. Rogers.
    This self-help guide is intended for scientists and medical professionals and students who wish to improve their scientific writing skills. Exercises invite the reader to practice the most important aspects of scientific writing. Although the book addresses certain issues more troublesome to scientific communicators of a non-English language origin, the guide will be of equal benefit to those whose first language is English. If you want not only to write but to write well, this book is for you. This second edition takes into account new developments in the area of scientific communication. In particular, the importance of authenticity is addressed, drawing attention to the sensitive issue of plagiarism in scientific texts.
  • 2007From: Springer
    Silvia M. Rogers.
  • 2011From: CRCnetBASE
    Mohamed M. Shoukri.
    "Emphasizing applications over theory, this book provides a comprehensive survey of this method and provides readers with standards and directions on how to run sound clinical and other types of studies. The author clearly explains how to reduce measurement error and presents numerous practical examples of the interobserver agreement approach. To help with problem solving, he includes SAS code, both within the book and on the CRC website. An extensive review of the literature offers access to the latest developments in the field. This edition presents new applications, new tables, more detail on SAS, new code, updated references, and two new chapters"--Provided by publisher.
  • 2006Click LINK above for Print location/circulation status.
    2006From: CRCnetBASE
    [edited by] Theodore R. Kucklick.
  • 2010From: WHO
    Also available: Print – 2010
  • 2016From: Oxford Medicine Online
    Charles Fried ; edited by Franklin Miller and Alan Wertheimer.
    This new edition of Charles Fried's Medical Experimentation includes a general introduction by Franklin Miller and the late Alan Wertheimer, a reprint of the 1974 text, an in-depth analysis by Harvard Law School scholars I. Glenn Cohen and D. James Greiner, and a new essay by Fried reflecting on the original text and how it applies to the contemporary landscape of medicine and medical experimentation.
  • 2011From: Springer
    Robert B. Taylor.
    Getting Started in Medical Writing -- Basic Writing Skills -- From Page One to the End -- Technical Issues in Medical Writing -- What's Special About Medical Writing? -- How to Write a Review Article -- Case Reports, Editorials, Letters to the Editor, Book Reviews, and Other Publication Models -- Writing Book Chapters and Books -- How to Write a Research Protocol -- How to Write a Grant Proposal -- How to Write a Report of a Clinical Study -- Getting Your Writing Published.
  • 2011From: Springer
    David A. Schwartz, editor.
    Physician-scientists are unusual creatures. While we are drawn to the clinical challenges of our patients, we are also drawn to the opportunities that our patients' medical problems bring to science. This book contains the unique experiences and encounters that drew 21 accomplished physician-scientists to this profession. These personal stories are those of people and circumstances that have had profound effects on our career decisions, our creative opportunities, and our lives. These stories also serve to highlight the lessons learned along the way and the distinct attributes of these women and men of medicine and science. Our combined hope is that our collective biographies will enhance the public understanding of our profession, will move people from medicine to science and from science to medicine, and will inspire those who are contemplating this extraordinary profession.
  • 2017From: CRCnetBASE
    Mallikarjun B. Hanji.
    Protocol writing for meta-analysis study -- Formulation of research problem -- Location and selection of studies -- Quality assessment of selected studies -- Effect sizes of primary studies -- Preparation of meta-analysis master sheet -- Meta-analysis plots -- Meta-analysis of two studies -- Methods for pooling estimates : fixed effects mode -- Method for pooling estimates : random effects model -- Individual patient data meta-analysis -- Meta-analysis of observational studies -- Additional meta-analysis techniques -- Reporting meta-analysis results -- Implications of results of meta-analysis -- Meta-analysis software -- Running meta-analysis using STATA.
  • 2008From: CRCnetBASE
    Dankmar Böhning, Ronny Kuhnert, Sasivimol Rattanasiri.
  • 2014From: Wiley
    edited by N. Balakrishnan.
  • 2014From: Wiley
    edited by N. Balakrishnan.
  • Dorfman, Ralph I.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Chemical determinations -- v. 2. Bioassay -- v. 3. & 4. Steroidal activity in experimental animals and man, Part A & B.
  • 2011From: Springer
    William C.S. Cho, editor.
    1 -- MicroRNAs in Cancer (An Overview) -- 2. The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis -- 3. MicroRNAs in Breast Cancer -- 4. MicroRNAs in Colorectal Cancer -- 5. MicroRNAs in Gastric Cancer -- 6. MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets?- 7. MicroRNAs in Hepatocellular Carcinoma -- 8. MicroRNAs in Cervical Carcinoma -- 9. MicroRNAs in Esophageal Cancer -- 10. MicroRNAs in Bladder Cancer -- 11. MicroRNAs in Lymphoma -- 12. MicroRNAs in Leukemia -- 13. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools -- 14. MicroRNAs in Epithelial Ovarian Cancer -- 15. MicroRNAs in Brain Tumors -- 16. MicroRNAs and Cancer Stem Cells -- 17. MicroRNAs in Cancer Invasion and Metastasis -- 18. MicroRNAs in Predicting Radiotherapy and Chemotherapy Response -- 19. Role of MicroRNAs in Anti-cancer Drug Resistance -- 20. MicroRNAs and Cancer Metabolism -- 21. MicroRNAs as Blood-based Biomarkers of Cancer -- 22. RNAi-based Approaches to the Treatment of Brain Tumors.
  • 2003From: Wellcome Trust
    edited by L.A. Reynolds and E.M. Tansey.
    "This transcript considers the origins and impact of the MRC Applied Psychology Unit's work from 1944 to 1998."
  • 2006From: ScienceDirect
    edited by Ray Paton and Laura A. McNamara.
  • 2013From: Wiley
    James R. Carpenter, Michael G. Kenward.
    Introduction -- The multiple imputation procedure and its justification -- Multiple imputation of quantitative data -- Multiple imputation of binary and ordinal data -- Multiple imputation of unordered categorical data -- Nonlinear relationships -- Interactions -- Survival data, skips and large datasets -- Multilevel multiple imputation -- Sensitivity analysis: MI unleashed -- Including survey weights -- Robust multiple imputation.
  • 2010From: CRCnetBASE
    edited by Alex Dmitrienko, Ajit C. Tamhane, Frank Bretz.
    1. Multiplicity problems in clinical trials : a regulatory perspective / Mohammad Huque and Joachim Rèohmel -- 2. Multiple testing methodology / Alex Dmitrienko ... [et al.] -- 3. Multiple testing in dose-response problems / Frank Bretz, Ajit C. Tamhane, and Josâe Pinheiro -- 4. Analysis of multiple endpoints in clinical trials / Ajit C. Tamhane and Alex Dmitrienko -- 5. Gatekeeping procedures in clinical trials / Alex Dmitrienko and Ajit C. Tamhane -- 6. Adaptive designs and confirmatory hypothesis testing / Willi Maurer, Michael Branson, and Martin Posch -- 7. Design and analysis of microarray experiments for pharmacogenomics / Jason C. Hsu ... [et al.].
  • 2011From: CRCnetBASE
    Damon M. Berridge, Robert Crouchley.
    Machine generated contents note: 2.1. Introduction -- 2.2. Continuous/interval scale data -- 2.3. Simple and multiple linear regression models -- 2.4. Checking assumptions in linear regression models -- 2.5. Likelihood: multiple linear regression -- 2.6. Comparing model likelihoods -- 2.7. Application of a multiple linear regression model -- 2.8. Exercises on linear models -- 3.1. Binary data -- 3.1.1. Introduction -- 3.1.2. Logistic regression -- 3.1.3. Logit and probit transformations -- 3.1.4. General logistic regression -- 3.1.5. Likelihood -- 3.1.6. Example with binary data -- 3.2. Ordinal data -- 3.2.1. Introduction -- 3.2.2. The ordered logit model -- 3.2.3. Dichotomization of ordered categories -- 3.2.4. Likelihood -- 3.2.5. Example with ordered data -- 3.3. Count data -- 3.3.1. Introduction -- 3.3.2. Poisson regression models -- 3.3.3. Likelihood -- 3.3.4. Example with count data -- 3.4. Exercises -- 4.1. Introduction -- 4.2. The linear model 4.3. The binary response model -- 4.4. The Poisson model -- 4.5. Likelihood -- 5.1. Introduction -- 5.2. Linear mixed model -- 5.3. The intraclass correlation coefficient -- 5.4. Parameter estimation by maximum likelihood -- 5.5. Regression with level-two effects -- 5.6. Two-level random intercept models -- 5.7. General two-level models including random intercepts -- 5.8. Likelihood -- 5.9. Residuals -- 5.10. Checking assumptions in mixed models -- 5.11. Comparing model likelihoods -- 5.12. Application of a two-level linear model -- 5.13. Two-level growth models -- 5.13.1. A two-level repeated measures model -- 5.13.2. A linear growth model -- 5.13.3. A quadratic growth model -- 5.14. Likelihood -- 5.15. Example using linear growth models -- 5.16. Exercises using mixed models for continuous/interval scale data -- 6.1. Introduction -- 6.2. The two-level logistic model -- 6.3. General two-level logistic models -- 6.4. Intraclass correlation coefficient -- 6.5. Likelihood -- 6.6. Example using binary data -- 6.7. Exercises using mixed models for binary data 7.1. Introduction -- 7.2. The two-level ordered logit model -- 7.3. Likelihood -- 7.4. Example using mixed models for ordered data -- 7.5. Exercises using mixed models for ordinal data -- 8.1. Introduction -- 8.2. The two-level Poisson model -- 8.3. Likelihood -- 8.4. Example using mixed models for count data -- 8.5. Exercises using mixed models for count data -- 9.1. Introduction -- 9.2. The mixed linear model -- 9.3. The mixed binary response model -- 9.4. The mixed Poisson model -- 9.5. Likelihood -- 10.1. Introduction -- 10.2. Three-level random intercept models -- 10.3. Three-level generalized linear models -- 10.4. Linear models -- 10.5. Binary response models -- 10.6. Likelihood -- 10.7. Example using three-level generalized linear models -- 10.8. Exercises using three-level generalized linear mixed models -- 11.1. Introduction -- 11.2. Multivariate two-level generalized linear model -- 11.3. Bivariate Poisson model: example -- 11.4. Bivariate ordered response model: example -- 11.5. Bivariate linear-probit model: example -- 11.6. Multivariate two-level generalized linear model likelihood 11.7. Exercises using multivariate generalized linear mixed models -- 12.1. Introduction -- 12.1.1. Left censoring -- 12.1.2. Right censoring -- 12.1.3. Time-varying explanatory variables -- 12.1.4. Competing risks -- 12.2. Duration data in discrete time -- 12.2.1. Single-level models for duration data -- 12.2.2. Two-level models for duration data -- 12.2.3. Three-level models for duration data -- 12.3. Renewal data -- 12.3.1. Introduction -- 12.3.2. Example: renewal models -- 12.4. Competing risk data -- 12.4.1. Introduction -- 12.4.2. Likelihood -- 12.4.3. Example: competing risk data -- 12.5. Exercises using renewal and competing risks models -- 13.1. Introduction -- 13.2. Mover-stayer model -- 13.3. Likelihood incorporating the mover-stayer model -- 13.4. Example 1: stayers within count data -- 13.5. Example 2: stayers within binary data -- 13.6. Exercises: stayers -- 14.1. Introduction to key issues: heterogeneity, state dependence and non-stationarity -- 14.2. Example -- 14.3. Random effects models -- 14.4. Initial conditions problem -- 14.5. Initial treatment 14.6. Example: depression data -- 14.7. Classical conditional analysis -- 14.8. Classical conditional model: example -- 14.9. Conditioning on initial response but allowing random effect uol to be dependent on z3 -- 14.10. Wooldridge conditional model: example -- 14.11. Modelling the initial conditions -- 14.12. Same random effect in the initial response and subsequent response models with a common scale parameter -- 14.13. Joint analysis with a common random effect: example -- 14.14. Same random effect in models of the initial response and subsequent responses but with different scale parameters -- 14.15. Joint analysis with a common random effect (different scale parameters): example -- 14.16. Different random effects in models of the initial response and subsequent responses -- 14.17. Different random effects: example -- 14.18. Embedding the Wooldridge approach in joint models for the initial response and subsequent responses -- 14.19. Joint model incorporating the Wooldridge approach: example -- 14.20. Other link functions -- 14.21. Exercises using models incorporating initial conditions/state dependence in binary data 15.1. Introduction -- 15.2. Fixed effects treatment of the two-level linear model -- 15.3. Dummy variable specification of the fixed effects model -- 15.4. Empirical comparison of two-level fixed effects and random effects estimators -- 15.5. Implicit fixed effects estimator -- 15.6. Random effects models -- 15.7. Comparing two-level fixed effects and random effects models -- 15.8. Fixed effects treatment of the three-level linear model -- 15.9. Exercises comparing fixed effects and random effects -- A.1. SabreR installation -- A.2. SabreR commands -- A.2.1. The arguments of the SabreR object -- A.2.2. The anatomy of a SabreR command file -- A.3. Quadrature -- A.3.1. Standard Gaussian quadrature -- A.3.2. Performance of Gaussian quadrature -- A.3.3. Adaptive quadrature -- A.4. Estimation -- A.4.1. Maximizing the log likelihood of random effects models -- A.5. Fixed effects linear models -- A.6. Endogenous and exogenous variables -- B.1. Getting started with R -- B.1.1. Preliminaries -- B.1.1.1. Working with R in interactive mode -- B.1.1.2. Basic functions -- B.1.1.3. Getting help B.1.1.4. Stopping R -- B.1.2. Creating and manipulating data -- B.1.2.1. Vectors and lists -- B.1.2.2. Vectors -- B.1.2.3. Vector operations -- B.1.2.4. Lists -- B.1.2.5. Data frames -- B.1.3. Session management -- B.1.3.1. Managing objects -- B.1.3.2. Attaching and detaching objects -- B.1.3.3. Serialization -- B.1.3.4. R scripts -- B.1.3.5. Batch processing -- B.1.4. R packages -- B.1.4.1. Loading a package into R -- B.1.4.2. Installing a package for use in R -- B.1.4.3. R and Statistics -- B.2. Data preparation for SabreR -- B.2.1. Creation of dummy variables -- B.2.2. Missing values -- B.2.3. Creating lagged response covariate data.
  • 2010From: NAP
    Committee on Cancer Clinical Trials and the NCI Cooperative Group Program, Board on Health Care Services.
    Introduction -- The science of developing cancer therapy -- Operations, oversight, and funding of cancer clinical trials -- Physician and patient participation in cancer clinical trials.
  • Mary Moran, Nick Chapman, Lisette Abela-Oversteegen, Vipul Chowdhary, Anna Doubell, Christine Whittall, Rachel Howard, Penny Farrell, Dale Halliday, Catherine Hirst.
    In 2014, a reported $3,377m was invested in neglected disease R&D, consisting of $3,197m from repeat survey participants (called year-on-year -- YOY -- funders) and $179m from irregular survey participants. Total YOY funding for neglected disease R&D increased by $150m (up 4.9%), but this was entirely the result of significant new investment in Ebola R&D in response to the 2014 West African Ebola epidemic. Without Ebola, YOY funding for neglected disease R&D would have been essentially unchanged from 2013 (down $14m, -0.4%).
  • 2012From: Springer
    Jill Scott, Esther Stoeckli, editors.
    Neural Development -- Visual Perception -- Tactile Perception -- Skin And Environment -- Conclusion: Neuromedia: Talking into the Future.
  • 2016From: OSO
    Ben Shneiderman.
    Part I. Guiding principles. -- 1. Combining applied and basic research : the ABC principle -- 2. Blending science, engineering, and design : the SED principle -- Part II. Science, engineering, and design. -- 3. What science contributes : persistence in understanding the world -- 4. What engineering contributes : devotion to innovative technologies -- 5. What design contributes : fresh thinking to serve human needs -- Part III. Research life cycle strategies. -- 6. Choose actionable problems that address civic, business, and global priorities -- 7. Apply observation, intervention, and controlled experiments -- 8. Form teams with diverse individuals and organizations -- 9. Test ideas and prototypes with realistic interventions -- 10. Promote adoption and assess impact -- Part IV. Making it happen. -- 11. Recommendations for action -- 12. Change is hard, but possible.
  • 1999From: NIH
    [Harold Varmus], Office of Director, National Institutes of Health.
  • 2001-From: NIH
    National Institutes of Health.
  • Pei He.
    In clinical trials, enrolled patients are randomized into treatment and control groups to test if the new treatment has advantages over the control. Data have been collected from both groups to form test statistics. For life-threatening diseases, such as cancer and heart attacks, the primary endpoint of a confirmatory trial for a new treatment is time to failure. This endpoint often involves censored data because some subjects may not fail by the end of the study or may have been lost to follow-up. To handle survival data in the problem of explanatory variables, Cox (1972) introduced a semi-parametric model based on the assumption of proportional hazards. In this model, the log ratio of the hazard function of the treatment group to that of the control group is a constant that does not vary over time. Earlier Mantel (1966) introduced the logrank test that is asymptotically efficient for proportional hazards alternative. Both logrank test and proportional hazards regression model have become standard procedures in clinical trials with survival endpoints. Since clinical trials can run for years, interim analyses by a Data and Safety Monitoring Board (DSMB) are typically included in the trial protocol. This led to the development of "time-sequential'' methods for early stopping during interim analyses. Lan and DeMets (1988) have noted that there are two time scales in time-sequential trials. One is the calendar time t at which interim analysis is carried out, and the other is the information time V(t), which can be measured by the variance of the test statistic (under the null hypothesis) based on all the data collected up to time t and is unknown before time t. Therefore, to determine the sample size and study duration, assumptions have to be made on the accrual rate, the survival distribution of both treatment and control groups, and the censoring distribution. These assumptions are commonly based on the literature concerning related studies and on educated guesses. In particular, since logrank tests and time-invariant hazard ratios are typically used to summarize the results of the studies, it is convenient to assume proportional hazards as the working model at the design stage. During interim analyses, marked discrepancies for the assumptions at the design stage may be observed. Herein we propose a group sequential design that addresses theses discrepancies and thereby makes the trial more efficient in terms of power, study duration and expected sample size. The design allows one to combine the logrank statistic with the more powerful test statistics in case of non-proportional hazards at the terminal stage. A new approach to futility stopping is developed as well as a piecewise constant hazard ratio model replacing the proportional hazards model.
  • 2008From: Springer
    Minoru Onozuka, Chen-Tung Yen, editors.
  • edited by Jørgen Fogh, Beppino C. Giovanella.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010From: Springer
    William C.S. Cho, editor.
  • 2011From: Springer
    Gustavo Duque, Ken Watanabe (editors).
    How to Select Your Animal Model for Osteoporosis Research / A. Simon Turner -- Skeletal Phenotyping in Rodents: Tissue Isolation and Manipulation / Janet E. Henderson, Chan Gao and Edward J. Harvey -- Methods in Bone Biology in Animals: Biomechanics / José B. Volpon and Antonio C. Shimano -- Methods in Bone Histomorphometry for Animal Models / Natalie Dion, Audray Fortin and Louis-Georges Ste-Marie -- Methods in Bone Biology in Animals: Imaging / Blaine A. Christiansen and Mary L. Bouxsein -- Methods in Bone Biology in Animals: Biochemical Markers / Markus Herrmann -- Methods in Bone Biology: Cancer and Bone / Yu Zheng, Markus J. Seibel and Hong Zhou -- How to Test Osteoporosis Treatments in Experimental Animals / Robert J. van ʻt Hof -- The Ovariectomized Mice and Rats / Jameela Banu -- Classical Models of Senile Osteoporosis / Ken Watanabe -- Animal Models of Premature Aging / Wei Li and Gustavo Duque -- Nonhuman Primate Models of Osteoporosis / Susan Y. Smith, Aurore Varela and Jacquelin Jolette -- Other Large Animal Models / Susan Reinwald and David B. Burr -- Mouse models for the Study of Fracture Healing and Bone Regeneration / Joerg H. Holstein, Patric Garcia, Tina Histing, Moritz Klein and Steven C. Becker, et al.
  • edited by H.C.G. Matthew and Brian Harrison.
  • Includes all of words, phrases, and translations, in French, German, Spanish and Italian from the print dictionaries. Users can search the full A-Z from both sides of the dictionary in Oxford's unabridged bilingual dictionaries: French, German, Spanish, and Italian.
  • 2008From: CRCnetBASE
    2008From: ProQuest Ebook Central
    edited by Tony Kennedy.
    Strategic project management at the project level / Tony Kennedy -- Strategic project management at the portfolio level / Kevin Bilyard and Des Markland -- Project planning : from basic concepts to systems application / Carl A. Kutzbach, Carole Strong, and Sylvia Walker -- Project management of chemical, analytical, and formulation development / Dieter Krimmer -- Project management in exclusive synthesis / Lukas M.J. von Hippel -- Clinical trials--can they be project managed? / Les Rose -- Regulatory project management / Nicholas Wells -- Teams / Ralph White -- Project management and outsourcing drug development / Jon Court and Mark Fowler -- The project management function / Tony Kennedy.
    Also available: Print – 2008
  • 2011From: Springer
    Mark J. Eisenberg.
    pt. 1. Getting started as physician-scientist. -- Beginnings -- Is a physician-scientist career right for you? -- Training as a physician-scientist -- pt. 2. Launching your career as a physician-scientist. -- Getting a job -- Appointments, tenure, promotions, and sabbaticals -- Teaching -- Administration -- Research -- pt. 3. Building your career as a physician-scientist. -- Writing -- Publishing -- Grants -- Grantsmanship -- Peer review of grant applications -- Managing your team, time, and money -- Mentorship -- Lectures and presentations -- Relations with industry -- pt. 4. Parting words of advice : putting it all together. -- Balancing research, clinical activities, and family life -- Improving the physician-scientist pathway -- Concluding remarks.
  • 2016From: Cambridge
    Robert A. Parker, Harvard Medical School, Nancy Greene Berman, School of Public Health, UCLA Los Angeles.
  • 2012From: Springer
    edited by Zdenko Machala, Karol Hensel, and Yuri Akishev.
  • collected by the Engineering foundation, New York, Jan. l5, 1921.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2002From: Wellcome
    edited by A.R. Ness, L.A. Reynolds, E.M. Tansey.
  • 2008From: Springer
    Berryman, A. A.; Berryman, A. A.; Kindlmann, Pavel.
  • [edited by] John I. Gallin, Frederick P. Ognibene.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012From: ScienceDirect
    edited by John Gallin, Frederick P. Ognibene.
    This expanded third edition provides an introduction to the conduct of clinical research as well as more comprehensive and expansive content about the infrastructure necessary for a successful clinical research organization or enterprise. With authors who are experts in clinical research in both the public and private sectors, this publication provides essential information to clinical investigators who wish to develop and conduct well designed patient-based research protocols that comply with rigorous study design, ethical, and regulatory requirements.
  • 2011From: Springer
    edited by Manuel Hidalgo, S. Gail Eckhardt, Elizabeth Garrett-Mayer, Neil J. Clendeninn.
    Basic biostatistics for the clinical trialist / Elizabeth G. Hill and Elizabeth Garrett-Mayer -- Fundamental concepts in clinical pharmacology / Daniel L. Gustafson and Erica L. Bradshaw-Pierce -- Bioanalycial methods in clinical drug development / Walter J. Loos, Peter de Bruijn and Alex Sparreboom -- Preclinical models for anticancer drug development / Edward A. Sausville -- Phase I clinical trials with anticancer agents / Stephen Leong ... [et al.] -- Phase II trials with anticancer agents / Hui K. Gan, J. Jack Lee and Lillian L. Siu -- Phase III clinical trials with anticancer agents / Wendy R. Parulekar and Daniel J. Sargent -- Pharmacokinetic studies in early anticancer drug development / Alex Sparreboom and Sharyn D. Baker -- Pharmacodynamic studies in early phase drug development / D. Ross Camidge, Robert C. Doebele and Antonio Jimeno -- Prediction of antitumor response / Fred R. Hirsch and Yu Shyr -- Imaging studies in anticancer drug development / David A. Mankoff -- Role of the U.S. Food and Drug Administration in cancer drug development / Ann T. Farrell, Ramzi N. Dagher and Richard Pazdur -- Early clinical trials with cytotoxic agents / M.J.A. de Jonge and Jaap Verweij -- Challenges and successes in developing effective anti-angiogenic agents / Laura Q.M. Chow and S. Gail Eckhardt -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Cancer chemoprevention / Christopher H. Lieu, William N. William Jr. and Scott Lippman -- Combined modality therapy in cancer management / David Raben and Kyle Rusthoven -- Cancer vaccines / Daniel Laheru -- Optimising the development of antibodies as treatment for cancer / Craig P. Carden, Hendrik-Tobias Arkenau and Johann S. de Bono -- Oligonucleotide therapeutics / Cy A. Stein, Britta Hoehn and John Rossi -- Anticancer drug development in pediatric patients / Lia Gore and Margaret Macy -- Clinical trials in special populations / S. Percy Ivy ... [et al.] -- NCI-sponsored clinical trials / Andriana Papaconstantinou and Janet E. Dancey.
  • 2012From: Springer
    Phyllis G. Supino, Jeffrey S. Borer, editors ; foreword by Stephen E. Epstein.
  • 2015From: ScienceDirect
    edited by Martin Wehling, Department of Clinical Pharmacology Mannheim, University of Heidelberg, Mannheim, Germany.
    Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.
  • edited by Martin Wehling ; foreword by Francesco M. Marincola.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction and definitions -- Target identification and validation -- Biomarkers -- Early clinical trial design -- Pharmaceutical toxicology -- Translational science biostatistics -- Learning by experience : examples of translational processes in the cardiovascular field.
  • 2011From: WHO
    Background -- Scope, goal, objectives and target audience -- Global burden of NCDs -- Role of research in the implementation of the Global Strategy Action Plan -- Need for a prioritized research agenda for prevention and control of major NCDs to improve public health -- Achievable outcomes through a prioritized research agenda for prevention and control of major NCDs -- Process for the development of the WHO NCD research agenda. Initial phase of development of the WHO NCD research agenda -- Ranking process -- Finalization of WHO NCD research agenda -- Key domains for research. Major NCDs. Cardiovascular disease (CVD) -- Cancer -- Chronic respiratory diseases -- diabetes -- NCD risk factors. Tobacco control -- Nutrition, physical activity and obesity -- Cross-cutting domains. Primary health care approach for prevention and control of NCDs -- Social determinants and NCDs -- Genetics -- Promoting use of research findings to policies and practice for prevention and control of noncommunicable diseases -- Top 20 priority areas for NCD research -- Key elements required for strengthening the research capacity of low- and middle-income countries for implementation of the WHO NCD research agenda. Contents of the compact disc: -- 1. Working papers -- 2. Reports of Meetings to develop the Prioritized NCD research agenda (2008-2010) -- 3. Lists of participants -- 4. List of other contributors and institutions that participated in the process of development and review of the prioritized NCD research agenda.
    Also available: Print – 2011
  • edited by G. L. Cantoni & David R. Davies.
    PrintStatus: Not Checked OutLane Catalog Record
  • v. 3-27, 1969-94.From: Karger
    Also available: Print – v. 8, 1975.
  • 2002From: AAMC
    Task Force on Financial Conflicts of Interest in Clinical Research.
  • 2007From: Karger
    volume editors, P. Porcelli, N. Sonino.
    Development of a new assessment strategy in psychosomatic medicine: the diagnostic criteria for psychosomatic research / S. Fabbri ... [et al.] -- Psychosocial approach to endocrine disease / N. Sonino, E. Tomba, G.A. Fava -- Psychological factors affecting functional gastrointestinal disorders / P. Porcelli, O. Todarello -- Psychological factors affecting oncology conditions / L. Grassi ... [et al.] -- Psychological factors affecting cardiologic conditions / C. Rafanelli ... [et al.] -- Toward a biopsychosocial approach to skin diseases / A. Picardi, P. Pasquini -- Psychological factors affecting medical conditions in consultation-liaison psychiatry / A. Bellomo ... [et al.] -- Psychological factors affecting medical conditions in consultation-liaison psychiatry / A. Bellomo ... [et al.] -- Psychological factors affecting eating disorders / S. Fassino ... [et al.].
  • 2015From: Springer
    Omar C.G. Gelo, Alfred Pritz, Bernd Rieken, editors.
    This book provides readers with essential information on the foundations of psychotherapy research, and on its applications to the study of both psychotherapy process and outcome. The aim is to stimulate a reflection on these issues in a way that will benefit researchers and clinicians, as well as undergraduate and graduate students, at different levels and from different perspectives. Accordingly, the book presents a balanced mix of chapters summarizing the state of the art in the field from different viewpoints and covering innovative topics and perspectives, reflecting some of the most established traditions and, at the same time, emerging approaches in the field in several countries. The contributors, who were invited from among the experts in our national and international professional networks, also represent a healthy mix of leading figures and young researchers. The first part of the book addresses a number of fundamental issues in psychotherapy research at a historical, philosophical, and theoretical level. The second part of the book is concerned with research on psychotherapy processes; in this regard, both quantitative and qualitative approaches are given equal consideration in order to reflect the growing relevance of the latter. The book's third and last part examines research on psychotherapy outcomes, primarily focusing on quantitative approaches. Offering a balanced mix of perspectives, approaches and topics, the book represents a valuable tool for anyone interested in psychotherapy research.
  • 2006From: Wiley
    edited by Catherine Pope, Nicholas Mays.
    Qualitative methods in health research / Catherine Pope, Nicholas Mays -- Qualitative interviews / Nicky Britten -- Focus groups / Jenny Kitzinger -- Observational methods / Catherine Pope, Nicholas Mays -- Conversation analysis / Sarah Collins, Nicky Britten -- Ethical issues / Dawn Goodwin -- Analysing qualitative data / Catherine Pope, Sue Ziebland, Nicholas Mays -- Quality in qualitative health research / Nicholas Mays, Catherine Pope -- Combining qualitative and quantitative methods / Alicia O'Cathain, Kate Thomas -- Case studies / Justin Keen -- Action research / Julienne Meyer -- Consensus development methods / Nick Black -- Synthesising qualitative research / Catherine Pope and Nicholas Mays.
  • 2012From: CRCnetBASE
    edited by Isabelle Boutron, Philippe Ravaud, David Moher.
    "Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable devices, nonimplantable devices, rehabilitation, psychoteherapy, and behavioral interventions. This book focuses on the methods of assessing nonpharmacological treatments, highlighting specific issues and discussing all possible design of trials. It provides practical examples to underline the issues and solutions in assessing nonpharmacological treatment in trials. Arguably the first book to exclusively explore this topic, it discusses various categories of treatments from surgical procedures to psychotherapy"--Provided by publisher.
  • 2012From: ScienceDirect
    [edited by] Xin-Yuan Liu, Sidney Pestka, Yu-Fang Shi.
    Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super.
  • 2011From: NAP
    Committee on Advancing Pain Research, Care, and Education, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
    1. Introduction -- 2. Pain as a Public Health Challenge -- 3. Care of People with Pain -- 4. Education Challenges -- 5. Research Challenges -- 6. A Blueprint for Transforming Pain Prevention, Care, Education, and Research -- Glossary -- A. Data Sources and Methods -- B. Summary of Written Public Testimony -- C. The Economic Costs of Pain in the United States -- D. Committee and Staff Biographies.
  • 2010From: WHO
    "This overview outlines the statutory background for WHO's research, identifies the milestones in health research over five decades, and discusses issues of both process and programs. This report also includes accounts of regional efforts in health research"--Publisher's description. African region; Eastern Mediterranean region; European region; South East Asia region; Western Pacific region; Pan American Health Organization
    Also available: Print – 2010
  • 2014From: ProQuest Ebook Central
    edited by Joyce M. Ray.
    It has become increasingly accepted that important digital data must be retained and shared in order to preserve and promote knowledge, advance research in and across all disciplines of scholarly endeavor, and maximize the return on investment of public funds. To meet this challenge, colleges and universities are adding data services to existing infrastructures by drawing on the expertise of information professionals who are already involved in the acquisition, management and preservation of data in their daily jobs. Data services include planning and implementing good data management practices, thereby increasing researchers' ability to compete for grant funding and ensuring that data collections with continuing value are preserved for reuse. This volume provides a framework to guide information professionals in academic libraries, presses, and data centers through the process of managing research data from the planning stages through the life of a grant project and beyond. It illustrates principles of good practice with use-case examples and illuminates promising data service models through case studies of innovative, successful projects and collaborations.
  • 2013From: Cambridge
    [edited by] Gary L. Comstock.
    "Ordinarily, responsible conduct of research (RCR) 'training' consists of lectures accompanied by generic exercises on 'core' topics. Research Ethics takes a novel, philosophical approach to the RCR and the teaching of moral decision-making. Part I introduces egoism and explains that it is in the individuals own interest to avoid misconduct, fabrication of data, plagiarism and bias. Part II takes up contractualism and covers issues of authorship, peer review and responsible use of statistics. Part III introduces moral rights as the basis of informed consent, the use of humans in research, mentoring, intellectual property and conflicts of interests. Part IV uses two-level utilitarianism to explore the possibilities and limits of the experimental use of animals, duties to the environment and future generations, and the social responsibilities of researchers. This book replaces mind-numbing rote exercises with an adventure in moral imagination and is an essential guide for graduate students in all disciplines"-- Provided by publisher.
  • 2013From: Springer
    Daron Smith, Dan Wood.
    Research in Clinical Practice is a neat, pocket-sized reference guide examining how to get the most from actively participating in research. Including how to begin, avoiding pitfalls, whom to approach and what questions to ask - all significant practicalities for conducting research in the reader's area of interest. Each reader will learn how to make the best use of such a valuable time. Written by two experienced surgeons, both of whom achieved post graduate research degrees, Research in Clinical Practice, is an essential tool for clinicians embarking on a research project as well as those who are new to supervising researchers.
  • 2008From: Stanf Univ
    Topics include self-Management, self-Efficacy, health Status, and some diabetes-specific scales.
  • 2016From: ProQuest Ebook Central
    Lynn Silipigni Connaway and Marie L. Radford.
    Research and librarianship -- Developing the research study -- Principles of quantitative methods -- Survey research -- Experimental research -- Analysis of qualitative data -- Principles of qualitative methods -- Individual interviews -- Ethnographic approaches to qualitative research -- Analysis of qualitative data -- Historical research -- Applied research -- Writing the research proposal -- Written and oral presentation of the research project.
  • [edited by] Julia M. Addington-Hall, Eduardo Bruera, Irene J. Higginson, Sheila Payne.
    PrintStatus: Not Checked OutLane Catalog Record
    Ethical and practice issues in qualitative research / Frances Sheldon and Anita Sargeant -- Evaluating qualitative research / Michelle Crossley -- Mixed methods for evaluation research / Christine Ingleton and Sue Davies -- Ethnography / Jane Seymour -- Documentary analysis and policy / Margaret O'Connor -- How to develop a research question / Laura Kelly and Patrick Stone -- Writing a research proposal / Chris Todd -- How to gain research ethics approval / Peter Speck -- How to use a statistician / Malcolm Campbell -- How to write a paper / Julia M. Addington-Hall. Principles of designing clinical trials in palliative care / Michael I. Bennett -- Ethical and practical issues in designing and conducting clinical trials in palliative care / Yolanda Zuriarrain Reyna, Michael I. Bennett, and Eduardo Bruera -- Survey design / Julia M. Addington-Hall -- Survey research : methods of data collection, questionnaire design, and piloting / Julia M. Addington-Hall -- Experimental and quasi-experimental designs / Massimo Costantini and Irene J. Higginson -- Outcome measurement / Irene J. Higginson and Richard Harding -- Systematic reviews / Marjolein Gysels and Irene J. Higginson -- Qualitative methods of data collection and analysis / Sheila Payne --
  • 2013From: ProQuest Ebook Central
    Barbara K. Redman.
  • 2015From: ScienceDirect
    edited by Mark A. Suckow, University of Notre Dame, Office of Research Notre Dame, IN, USA ; Bill J. Yates, University of Pittsburgh, Department of Otolaryngology Pittsburgh, PA, USA.
    Ch. 1. Human subjects research protections -- Ch. 2. Investigational new drug and device exemption process -- Ch. 3. The institutional animal care and use committee -- Ch. 4. Biological hazards and select agents -- Ch. 5. Radiological hazards and lasers -- Ch. 6. Controlled substances: maintaining institutional compliance -- Ch. 7. Export controls and US research universities -- Ch. 8. Data management and research integrity -- Ch. 9. Intellectual property -- Ch. 10. Financial conflicts of interest in research -- Ch. 11. Good laboratory practices (GLPs) -- Ch. 12. Human embryonic stem cell research oversight: a confluence of voluntary self-regulation and shifting policy initiatives -- Index.
  • 2011From: ProQuest Ebook Central
    Committee to Study the National Needs for Biomedical, Behavioral, and Research Personnel, Board on Higher Education and Workforce, Policy and Global Affairs, National Research Council of the National Academies.
    "Comprehensive research and a highly trained workforce are essential for the improvement of health and health care both nationally and internationally. Over the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph. D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum."--Publisher's description.
  • 2009From: OSO
    Adil E. Shamoo and David B. Resnik.
    Scientific research and ethics -- Ethical decision making -- Data acquisition and management -- Mentoring and collaboration -- Collaboration between academia and private industry -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The protection of human subjects in research -- Protecting vulnerable human subjects in research -- Genetics, cloning, and stem cell research -- International research.
  • Richard Harris.
    PrintStatus: Not Checked OutLane Catalog Record
    American taxpayers spend $30 billion annually funding biomedical research. By some estimates, half of the results from these studies can't be replicated elsewhere -- the science is simply wrong. Often, research institutes and academia emphasize publishing results over getting the right answers, incentivizing poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence. How are those with breast cancer helped when the cell on which 900 papers are based turns out not to be a breast cancer cell at all? How effective could a new treatment for ALS be when it failed to cure even the mice it was initially tested on? Science journalist Richard F. Harris reveals these urgent issues with anecdotes, personal stories, and interviews with the nation's top biomedical researchers.
  • 2014From: CRCnetBASE
    Rabindra Nath Das.
    "The present book initiates the concept of robust response surface designs, along with the relevant regression and positive data analysis techniques. Response surface methodology (RSM), well-known in literature, is widely used in every field of science and technology such as Biology, Natural (Physical/Chemical), Environmental, Medical, Agricultural, Quality engineering etc. RSM is the most popular experimental data generating, modeling and optimization technique in every field of science. It is a particular case of robust response surface methodology (RRSM). RSM has many limitations, and RRSM aims to overcome many of such limitations. Thus, RRSM will be much better than RSM. It is intended for anyone who knows basic concepts of experimental designs and regression analysis. This is the first unique book on RRSM. Every chapter is unique regarding its contents, presentation and organization. Problems on robust response surface designs such as rotatability, slope-rotatability, weak rotatability, optimality, and along with the method of estimation of model parameters, positive data analysis techniques are considered in this book. Some real examples on lifetime responses, resistivity, replicated measures, medical, demography, hydrogeology data etc., are analysed. Some examples (considered in this book) on design of experiments do not satisfy the classical assumptions of response surface methodology."-- Provided by publisher.
  • 2007From: NAP
  • 2007From: SAGE
    edited by Antony Bryant, Kathy Charmaz.
    Grounded theory in historical perspective : an epistemological account / Antony Bryant, Kathy Charmaz -- The discovery of grounded theory in practice : the legacy of multiple mentors / Eleanor Krassen Covan -- Living grounded theory : cognitive and emotional forms of pragmatism / Susan Leigh Star -- Doing formal theory / Barney G. Glaser -- On solid ground : essential properties for growing grounded theory / Phyllis Noerager Stern -- From the sublime to the meticulous : the continuing evolution of grounded formal theory / Margaret H. Kearney -- Orthodoxy vs. power : the defining traits of grounded theory / Jane C. Hood -- Grounding categories / Ian Dey -- The development of categories : different approaches in grounded theory / Udo Kelle -- Abduction : the logic of discovery of grounded theory / Jo Reichertz -- Sampling in grounded theory / Janice M. Morse -- Asking questions of the data : memo writing in the grounded theory tradition / Lora Bex Lempert -- The coding process and its challenges / Judith A. Holton -- Making teams work in conducting grounded theory / Carolyn Wiener -- Teaching grounded theory / Sharlene Nagy Hesse-Biber -- The evolving nature of grounded theory method : the case of the information systems discipline / Cathy Urquhart -- Grounded theorizing using situational analysis / Adele E. Clarke, Carrie Friese -- What can grounded theorists and action researchers learn from each other? / Bob Dick -- Feminist qualitative research and grounded theory : complexities, criticisms, and opportunities / Virginia L. Olesen -- Accommodating critical theory / Barry Gibson -- Grounded theory and racial/ethnic diversity / Denise O'Neil Green [and others] -- Advancing ethnographic research through grounded theory practice / Stefan Timmermans, Iddo Tavory -- Grounded theory and reflexivity / Katja Mruck, Günther Mey -- Mediating structure and interaction in grounded theory / Bruno Hildenbrand -- Rational control and irrational free-play : dual-thinking modes as necessary tension in grounded theorizing / Karen Locke -- Research as pragmatic problem-solving : the pragmatist roots of empirically-grounded theorizing / Jörg Strübing.
  • edited by Norman K. Denzin, Yvonna S. Lincoln.
    PrintStatus: Not Checked OutLane Catalog Record
    The editors and contributors address issues of social justice and examine how people's struggles can inform public issues and in turn be transformed into social policy. Their writings are underpinned by a critical framework, and they are committed to addressing issues of inequality. As with previous editions, their aim is to show how the practices of qualitative research can effect change in the world in positive ways.--From publisher description.
  • 2008From: CRCnetBASE
    [edited by] Shein-Chung Chow, Jun Shao, Hansheng Wan.
    Considerations prior to sample size calculation -- Comparing means -- Large sample tests for proportions -- Exact tests for proportions -- Tests for goodness-of-fit and contingency tables -- Comparing time-to-event data -- Group sequential methods -- Comparing variabilities -- Bioequivalence testing -- Dose response studies -- Microarray studies -- Bayesian sample size calculation -- Nonparametrics -- Sample size calculation in other areas.
  • 2011From: Springer
    John Blackwell, Jan Martin.
    The book does not focus primarily on grammar, but includes sections on important facets, such as 'voices' and tenses. It also addresses problems associated with writing other texts (reports, reviews, emails, social/professional networking communications etc.). Composed (with inputs from numerous senior scientists) by authors who have written, revised or edited more than 4,000 papers, A Scientific Approach to Scientific Writing will be essential reading for non-native English-speaking students and researchers of all disciplines, and a valuable resource for those with English as a first language."--pub. desc.
  • Javier Arias-Stella.
    PrintStatus: Not Checked OutLane Catalog Record
    Describes the path that led to the discovery of the Arias-Stella reaction. Uses fictional names for the local protagonists, e.g., Pedro Asari Saltel for Javier Arias-Stella.
  • 2011From: CRCnetBASE
    Finlay MacRitchie.
    1. Introduction -- 2. Scientific training and personal development -- 3. The scientific method -- 4. Attributes required by research scientists -- 5. The impact of managerialism -- 6. Leadership in science -- 7. Insights from notable scientists -- 8. Future challenges for scientific research.
  • 2013From: Wiley
    Caroline De Brún, Nicola Pearce-Smith.
    This is a user-friendly, hands-on guide to literature searching, which is an essential skill for all involved in health care research and development, researchers, and students from all disciplines.
  • 2007From: Springer
    edited by Christopher J.O. Baker and Kei-Hoi Cheung.
  • 2015From: NAP
    Committee on Strategies for Responsible Sharing of Clinical Trial Data, Board on Health Sciences Policy, Institute of Medicine.
    Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.
  • 2016From: Oxford Medicine Online
    Rebecca Dresser.
    The research ethics system was created without the help of people who know what it is like to be a research subject. This is a serious omission. Experts have overlooked ethical issues that matter to subjects. Silent Partners moves subjects to the forefront, giving them a voice in research ethics.
  • 2009From: Springer
    Janine E. Janosky, Shelley L. Leininger, Michael P. Hoerger, Terry M. Libkuman.
  • 2012From: Springer
    Herbert Blumberg, M. Valerie Kent, A. Paul Hare, Martin F. Davies.
  • 2008From: Springer
    edited by P. Michael Conn.
  • 2010From: Springer
    Ton J. Cleophas, Aeilko H. Zwinderman.
    Introduction -- One-Sample Continuous and Binary Data (t-Test, z-Test) (10 and 55 Patients) -- Paired Continuous Data (Paired-t, Wilcoxon) (10 Patients) -- Unpaired Continuous Data (Unpaired t-Tests, Mann-Whitney) (20 Patients) -- Linear Regression (20 Patients) -- Repeated Measures ANOVA, Friedman (10 Patients) -- Mixed Models (20 Patients) -- One-Way-ANOVA, Kruskall-Wallis (30 Patients) -- Trend Test for Continuous Data (30 Patients) -- Unpaired Binary Data (Chi-Square, Crosstabs) (55 Patients) -- Logistic Regression (55 Patients) -- Trend Tests for Binary Data (106 Patients) -- Paired Binary (McNemar Test) (139 General Practitioners) -- Multiple Paired Binary Data (Cochran's Q Test) (139 Patients) -- Cox Regression (60 Patients) -- Cox Regression with Time-dependent Variables (60 Patients) -- Validating Qualitative Diagnostic Tests (575 Patients) -- Validating Quantitative Diagnostic Tests (17 Patients) -- Reliability Assessment of Qualitative Diagnostic Tests (17 Patients) -- Reliability Assessment of Quantitative Diagnostic Tests (17 Patients) -- Final Remarks.
  • Also available: Print – 1989.
    Also available: Print – 1989.
    Also available: Print – 1989.
  • 2006From: MyiLibrary
    Stephen D. Simon.
    Apples or oranges? -- selection of the control group -- Who was left out? exclusions, refusals, and drop-outs -- Mountain or molehill? the clinical importance of the results -- What do the other witnesses say? corroborating vidence -- Do the pieces fit together? systematic overviews and meta-analysis -- What do all these numbers mean? -- Where is the evidence? searching for information.
    Also available: Print – 2006
  • Elisa T. Lee, John Wenyu Wang.
  • 2006From: Springer
    Lemuel A. Moyé.
  • 2012From: Springer
    Ton J. Cleophas, Aeilko H. Zwinderman ; with help from Toine F. Cleophas, Eugene P. Cleophas, and Henny I. Cleophas-Allers.
  • 2015From: Springer
    Pieter H. Joubert, Silvia M. Rogers.
    A document may be based on accurate medical and scientific information, follow guidelines precisely, and be well written in clear and correct language, but may still fail to achieve its objectives. The strategic approach described in this book will help you to turn good medical and scientific writing into successful writing. It describes clearly and concisely how to identify the target audience and the desired outcome, and how to construct key messages for a wide spectrum of documents. Irrespective of your level of expertise and your seniority in the pharmaceutical, regulatory, or academic environment, this book is an essential addition to your supporting library. The authors share with you many years of combined experience in the pharmaceutical and academic environment and in the writing of successful outcome-driven documents.
  • 2013From: Ovid
    Richard K. Riegelman.
    Evidence-based information plays a critical role in clinical practice decisions. Secondary sources are often unreliable; it.s up to the student, then, to critically assess peer-reviewed research literature. Using a highly structured yet accessible method, this text teaches students to critically analyze research from primary sources. Step-by-step approach. learn to recognize a meaningful study, clues to potential study flaws, and ways to apply solid evidence in clinical practice. Simple 6-point framework. learn to evaluate studies in terms of the authors trademark mnemonic device, M.A.A.R.I.E. (Methods, Assignment, Assessment, Results, Interpretation and Extrapolation). Unique Learning Aids - question checklists, real-world scenarious, flaw-catching exercises and more help to make complex concepts easy to grasp.
  • 2014From: Springer
    Melina R. Kibbe, Scott A. LeMaire, editors.
    Academic surgeons play an essential role in advancing the field and improving the care of patients with surgical disease. As the Association for Academic Surgery (AAS) Fall Courses ( and international courses continue to evolve to address the rapidly expanding scope and complexity of academic surgery, there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Basic Science is a unique and portable handbook that focuses on the basic and translational research. It includes new educational materials that are necessary to address not only the rapid evolution and rise of novel research methodologies in basic science and translational research, but also the changing environment for academic surgeons. Success in Academic Surgery: Basic Science is a valuable text for medical students, surgical residents, junior faculty and others considering a career in surgical research.
  • 2012From: Springer
    Herbert Chen, Lillian S. Kao (editors).
  • 2008From: ProQuest Ebook Central
    Laura N. Gitlin, Kevin J. Lyons.
    Why write a grant? -- Becoming familiar with funding sources -- Developing your ideas for funding -- Common sections of proposals -- Strategies for effective writing -- Technical writing considerations -- Developing a budget -- Putting it all together to create a budget -- Technical considerations in budget development -- Four project structures -- Understanding the process of collaboration -- Forming a collaborative team -- Learning about your institution -- Electronic considerations -- Understanding the review process -- Responding to the proposal review -- A case study -- Welcome to the world of post-award -- More post-award considerations.
    Also available: Print – 2008
  • Andrew Booth, Anthea Sutton, and Diana Papaioannou.
    PrintStatus: Not Checked OutLane Catalog Record
    Getting started on your literature review -- Taking a systematic approach to your literature review -- Choosing your review methods -- Planning and conducting your literature review -- Defining your scope -- Searching the literature -- Assessing the evidence base -- Synthesising and analysing quantitative studies -- Synthesising and analysing qualitative studies -- Writing, presenting and disseminating your review.
  • Centre for Reviews and Dissemination.
    " ... provides practical guidance for undertaking evidence synthesis based on a thorough understanding of systematic review methodology. It presents the core principles of systematic reviewing, and in complementary chapters, highlights issues that are specific to reviews of clinical tests, public health interventions, adverse effects, and economic evaluations. The final chapter discusses the incorporation of qualitative research in or alongside effectiveness reviews"--Publisher.
  • 2014From: Ovid
    Heidi D. Nelson.
    1. Systematic reviews -- 2. Defining the topic and scope and developing research questions, analytic frameworks, and protocols -- 3. Building the systematic review team, engaging stakeholders, and managing the project -- 4. Determining inclusion and exclusion criteria for studies -- 5. Conducting searches for relevant studies -- 6. Selecting studies for inclusion -- 7. Extracting data from studies and constructing evidence tables -- 8. Assessing quality and applicability of studies -- 9. Qualitative analysis -- 10. Quantitative analysis -- 11. Assessing and rating the strength of the body of evidence -- 12. Preparing and disseminating the report.
  • 2012From: Springer
    Asfar S. Azmi, editor.
    Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • 2014From: Springer
    O.S. Miettinen.
    Scientific medicine in Miettinen's conception of it is very different from the two ideas about it that came to eminence in the 20th century. To him, medicine is scientific to the extent that it has a rational theoretical framework and a knowledge-base from medical science. He delineates the nature of that theoretical framework and of the research to develop the requisite knowledge for application in such a framework. The knowledge ultimately needed is about diagnostic, etiognostic, and prognostic probabilities, and it necessarily is to be codified in the form of probability functions, embedded in practice-guiding expert systems.
  • 2003From: Stanf Univ SOM
    [Stanford University School of Medicine].
  • 2015From: ScienceDirect
    Monty Montano.
  • 2013From: CRCnetBASE
    edited by James Mittra, Christopher-Paul Milne.
    Chapter 1. Introduction to Translational Medicine -- Chapter 2. New Light Through an Old Window? The "Translational Turn" in Biomedical Research -- Chapter 3. Translational Medicine -- Drivers and Barriers of TM -- Chapter 5. Developing an Evaluation Model for Translational Medicine Research Programs -- Chapter 6. Emerging Concepts in Biomarker Discovery -- Chapter 7. Imaging Biomarkers for Innovative Drug Development -- Chapter 8. Translational Bioinformatics -- Chapter 9. Exploiting Translational Medicine Through Public- Private Partnerships -- Chapter 10. The Role of the Product Development Partnership as a Translational Mechanism for Delivering Health Solutions in Low- Resource Settings.
  • 2009From: CRCnetBASE
    edited by Dennis Cosmatos, Shein-Chung Chow.
    Chapter 1. Translational Medicine / Dennis Cosmatos, Shein-Chung Chow -- Chapter 2. Strategic Concepts in Translational Medicine / Dennis Cosmatos, Giora Feuerstein, Shein-Chung Chow -- Chapter 3. Design and Analysis Approaches for Discovery Translational Medicine / Dennis Cosmatos, Shein-Chung Chow (Eds.), Stephen B. Forlow, Jennifer A. Isler, Zhaosheng Lin, Michael E. Burczynski, Jessie Q. Xia, S. Stanley Young -- Chapter 4. Biomarker Development / Mark Chang -- Chapter 5. Targeted Clinical Trials / Jen-pei Liu -- Chapter 6. Statistical Methods in Translational Medicine / Shein-Chung Chow, Siu-Keung Tse, Dennis Cosmatos -- Chapter 7. Nonparametric Methods in Translational Research / Kongming Wang, Shein-Chung Chow -- Chapter 8. Model Selection/Validation / Jen-pei Liu -- Chapter 9. Translation in Clinical Information between Populations-Bridging Studies / Chin-Fu Hsiao, Mey Wang, Herng-Der Chern, Jen-pei Liu -- Chapter 10. Translation in Clinical Technology-Traditional Chinese Medicine / Chin-Fu Hsiao, Hsiao-Hui Tsou, Shein-Chung Chow.
  • 2010From: CRCnetBASE
    edited by Lawrence Kruger, Alan R. Light.
    Painful multi-symptom disorders : a systems perspective / C. Richard Chapman -- Neurotrophic factors and nociceptor sensitization / Michael P. Jankowski and H. Richard Koerber -- The role of visceral afferents in disease / Julie A. Christianson and Brian M. Davis -- Cancer pain : from the development of mouse models to human clinical trials / Juan Miguel Jimenez Andrade and Patrick Mantyh -- Therapeutic targeting of peripheral cannabinoid receptors in inflammatory and neuropathic pain states / Igor Spigelman -- Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes / Ichiro Nishimura ... [et al.] -- Transgenic mouse models for the tracing of "pain" pathways / Allan I. Basbaum and João M. Bráz -- Cytokines in pain / Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers -- Glial modulation in pain states : translation into humans / Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo -- On the role of ATP-gated P2X receptors in acute, inflammatory, and neuropathic pain / Estelle Toulme ... [et al.] -- Myalgia and fatigue : translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes / Alan R. Light, Charles J. Vierck, and Kathleen C. Light -- Reflex autonomic responses evoked by group III and IV muscle afferents / Jennifer L. McCord and Marc P. Kaufman -- Central pain as a thalamocortical dysrhythmia : a thalamic efference disconnection? / Kerry D. Walton and Rodolfo R. Llinás -- What can neuroimaging tell us about central pain? / D.S. Veldhuijzen ... [et al.] -- Human brain imaging studies of chronic pain : translational opportunities / A. Vania Apkarian -- Consideration of pharmacokinetic pharmacodynamic relationships in the discovery of new pain drugs / Garth T. Whiteside and Jeffrey D. Kennedy -- Large animal models for pain therapeutic development / Darrell A. Henze and Mark O. Urban -- Drug discovery and development for pain / Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers.
  • 2015From: ScienceDirect
    Yoram Vodovotz, Gary An.
    Ch. 1.1. Interesting times: the translational dilemma and the need for translational systems biology of inflammation -- Ch. 2.1. A brief history of the philosophical basis of the scientific endeavor: how we know what we know, and how to know more -- Ch. 2.2. A brief history of biomedical research up to the molecular biology revolution -- Ch. 2.3. Biomedical research since the molecular revolution: an embarrassment of riches -- Ch. 2.4. Randomized clinical trials: a bridge too far? -- Ch. 2.5. Complexity in biomedical research: mysticism versus methods -- Ch. 2.6. Human nature, politics, and translational inertia -- Ch. 3.1. Towards translational systems biology of inflammation -- Ch. 3.2. Dynamic knowledge representation and the power of model making -- Ch. 3.3. A roadmap for a rational future: a systematic path for the design and implementation of new therapeutics -- Ch. 4.1. From data to knowledge in translational systems biology: an overview of computational approaches across the scientific cycle -- Ch. 4.2. Data-driven and statistical models: everything old is new again -- Ch. 4.3. Mechanistic modeling of critical illness using equations -- Ch. 4.4. Agent-based modeling and translational systems biology: an evolution in parallel -- Ch. 4.5. Getting science to scale: accelerating the development of translational computational models -- Ch. 5.1. What is old is new again: the scientific cycle in the twenty-first century and beyond -- Index.
  • 2014From: ProQuest Ebook Central
    David Bowers, Allan House, David Owens, Bridgette Bewick.
    Understanding Clinical Papers is a popular and well established introduction to reading clinical papers. It unravels the process of evidence-based practice, using real papers to illustrate how to understand and evaluate published research, and provides clear explanations of important research-related topics.
  • 2013From: AccessMedicine
    editors, Renato D. Lopes, Robert A. Harrington.
    Complete how-to guidance on conducting clinical research, this book addresses the operational challenges of clinical trials and provides a clear explanation of the methodologies necessary to interpret results. The book addresses all aspects of clinical trials, from design and implementation to statistics to regulatory scrutiny. A resource for students, residents, and clinicians who need a working knowledge of clinical research principles. The chapter authors are all leaders in the field and engaged in cutting edge clinical research. Use as a textbook, as a reference, and as a course guide for mandated clinical research training courses.
  • Abraham Flexner ; with a companion essay by Robbert Dijkgraaf.
    PrintStatus: Not Checked OutLane Catalog Record
    A forty-year tightening of funding for scientific research has meant that resources are increasingly directed toward applied or practical outcomes, with the intent of creating products of immediate value. In such a scenario, it makes sense to focus on the most identifiable and urgent problems, right? Actually, it doesn't. In his classic essay "The Usefulness of Useless Knowledge," Abraham Flexner, the founding director of the Institute for Advanced Study in Princeton and the man who helped bring Albert Einstein to the United States, describes a great paradox of scientific research. The search for answers to deep questions, motivated solely by curiosity and without concern for applications, often leads not only to the greatest scientific discoveries but also to the most revolutionary technological breakthroughs. In short, no quantum mechanics, no computer chips. This brief book includes Flexner's timeless 1939 essay alongside a new companion essay by Robbert Dijkgraaf, the Institute's current director, in which he shows that Flexner's defense of the value of "the unobstructed pursuit of useless knowledge" may be even more relevant today than it was in the early twentieth century. Dijkgraaf describes how basic research has led to major transformations in the past century and explains why it is an essential precondition of innovation and the first step in social and cultural change.
  • The Evidence-Based Medicine Working Group ; [edited by] Drummond Rennie ... [et al.].
    How to use the medical literature and this book to improve your patient care -- The philosophy of evidence-based medicine -- What is the question? -- Finding the evidence -- Why study results mislead: bias and random error -- Therapy -- Does treatment lower risk? Understanding the results -- Confidence intervals -- Advanced topics in the validity of therapy trials -- Hypothesis testing -- Advanced topics in applying the results of therapy trials -- Harm -- Advanced topics in harm -- The process of diagnosis -- Differential diagnosis -- Diagnostic tests -- Advanced topics in diagnosis -- How to critically appraise an article about prognosis -- Summarizing the evidence -- Advanced topics in systematic reviews -- How to use a patient management recommendation -- Advanced topics in moving from evidence to action.
  • 2014From: ProQuest Ebook Central
    Robert C. Hubrecht.
    The use of legislative and other controls on animal research to meet public expectations and improve animal welfare -- Animal rights and animal welfare : philosophy and science -- Species choice and animal welfare -- The harm/benefit judgement -- Improving the welfare of animals used in research : the 3Rs -- Science and animal welfare : a partnership.
  • 2009From: Springer
    Brian Stephen Budgell.
    This book is organized as a practical guide to writing a biomedical research article. Hence, as you will see from the table of contents, chapters are arranged according to the sequence of tasks that we normally encounter in our writing. The book deals only with writing and submission of manuscripts; there are no directions concerning, for example, the preparation of figures or audiovisual presentations. Furthermore, every chapter is concise; we do not beat topics to death. Exemplars of highly prevalent expressions are given throughout, however the number of examples in the book is not excessive.
  • 2006From: ScienceDirect
    Evan G. DeRenzo and Joel Moss.
    Introduction to the art and science of clinical research -- What you need to know about clinical research ethics -- What you need to know about the regulation of clinical research -- Designing a clinical research study -- Selecting subjects for clinical studies -- Risks and benefits in clinical research -- Recruiting subjects -- Informed consent -- Privacy and confidentiality -- The "ethics" section -- Procedures and methods -- Statistics, data collection and management, and record keeping -- Use of human biological materials -- Special issues raised by evolving areas of clinical research -- Case histories : learning from experience.
  • 2014From: CRCnetBASE
    Lisa Chasan-Taber.
    "For more than 15 years, I have taught a graduate course on grant proposal writing for students in the School of Public Health and Health Sciences at the University of Massachusetts at Amherst. With their encouragement and suggestions, this textbook has come to be a reality. Competition for research funds has never been more intense and, at the same time, the grant application and review process at such agencies as the National Institutes of Health (NIH) are undergoing significant transformation. Writing Dissertation and Grant Proposals: Epidemiology, Preventive Medicine, and Biostatistics is unique in representing an up-to-date textbook targeting effective grant proposal writing in this growing and important field. The text covers all aspects of the proposal-writing process from soup to nuts. Stepby- step tips address grant structure and style alongside broader strategies for developing a research funding portfolio. Throughout, concepts are illustrated with annotated examples from successfully funded proposals in the field. Strategies to avoid common errors and pitfalls (e.g., dos and don'ts) and summary checklists of guidelines are provided. Essentially, the text can be viewed as a virtual cookbook of the appropriate ingredients needed to construct a successful grant proposal. Therefore, this text is not only highly relevant for early-stage investigators including graduate students, medical students/residents, and postdoctoral fellows, but also valuable for more experienced faculty, clinicians, epidemiologists, and other health professionals who cannot seem to break the barrier to NIH-funded research"-- Provided by publisher.
  • Christopher J. Papasian [and] David C. Morrison.
    PrintStatus: Not Checked OutLane Catalog Record
    Understanding the biomedical publishing enterprise -- Preparation of a biomedical manuscript for publication -- Submission, review, revision and publication.
  • 2014From: CRCnetBASE
    Milos Jenicek.
    "Today, information in a medical article must include not only research activities and findings, but also strategic, managerial, and administrative ones. It might include planning, political, cultural, spiritual and other social aspects as well as experience in healthcare, health protection, disease prevention, and health promotion. This book is designed to help the authors of medical articles communicate better in today's practice and health research environment. It explores the most effective practices for communicating using three medical literature formats: scientific articles, articles where the subject is not based on the scientific method, and business reports"--Provided by publisher.
  • 2013From: ProQuest Ebook Central
    Margaret Cargill, BA, DipEd, MEd(TESOL), DEd, School of Agriculture Food and Wine, The University of Adelaide, Adelaide, South Australia 5005, Australia, Patrick O'Connor. BSc, PhD, School of Earth and Environmental Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
    This text guides authors in how to write, as well as what to write, to improve their chances of having their articles accepted for publication in international, peer reviewed journals.
  • 2007From: Springer
    edited by John L. Nitiss, Joseph Heitman.
    From DNA replication to genome instability in schizosaccharomyces pombe: pathways to cancer / Julie M. Bailis and Susan L. Forsburg -- Dissecting layers of mitotic regulation essential for maintaining genomic stability / Jeffiner S. Searle and Yolanda Sanchez -- Yeast as a tool in cancer research: nuclear trafficking / Anita H. Corbett and Adam C. Berger -- Studies of protein farnesylation in yeast / Nitika Thaper and Fuyuhiko Tamanoi -- From bread to bedside: what budding yeast has taught us about the immortalization of cancer cells / Soma S.R. Banik and Christopher M. Counter -- Hsp90 co-chaperones in saccharomyces cerevisiae / Marija Tesiccc and Richard F. Gaber -- Yeast as a model system for studying cell cycle checkpoints / Carmela Palermo and Nancy C. Walworth -- Metabolism and function of sphingolipids in saccharomyces cerevisiae: relevance to cancer research / L. Ashley Cowart, Yusuf A. Hannun, and Lina M. Obeid -- Exploring and restoring the p53 pathway using the p53 dissociator assay in yeast / Rainer K. Brachmann -- Functional analysis of the Human p53 tumor suppressor and its mutants using yeast / Alberto Inga, Francesca Storici and Michael A. Resnick -- ABC transporters in yeast - drug resistance and stress response in a nutshell / Karl Kuchler and Christoph Schüller -- The FHCRC/NCI yeast anticancer drug screen / Susan L. Holbeck and Julian Simon -- Yeast as a model to study the immunosuppressive and chemotherapeutic drug rapamycin / John R. Rohde, Sara A. Zurita-Martinez, and Maria E. Cardenas -- Use of yeast as a model of system for identifying and studying anti-cancer drugs / Jun O. Liu and Julian A. Simon -- Genetic analysis of cisplatin resistance in yeast and mammals / Seiko Ishida and Ira Herskowitz -- Using yeast tools to dissect the action of anti-cancer drugs: mechanisms of enzyme inhibition and cell killing: agents targeting DNA topoisomerases / Anna Rogojina, ... [et al].
all 248 titles

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