Books by Subject

all 340 titles


  • 2011From: Springer
    Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo, editors.
  • 2006-From: AccessMedicine
    Toy, Eugene C.
    Clinical cases selected from the LANGE Case Files series, edited by Eugene C. Toy, MD.
  • 2016From: Springer
    Corrado Angelini, editor.
    Foreword -- Introduction -- Part I Diagnosis of acquired myopathies -- Auto-Antibodies in Neuromuscular Disorders -- Electromyography -- Imaging of the Muscle -- Peripheral Nerve Ultrasound -- Magnetic Resonance Imaging of the Peripheral Nerve -- Part II Clinical Entities -- The Spectrum of Inflammatory Myopathies: Dermatomyositis, Polymyositis, Necrotizing Myositis and Inclusion Body Myositis -- Necrotising Myopathy -- Statin Myopathy -- Myasthenia Gravis -- Acquired Autoimmune Rippling Muscles with Myasthenia Gravis -- Endocrinological Myopathies -- Vitamin D deficiency in Muscle -- Intensive Care Unit Acquired Weakness -- Part III Neurogenic disorders -- Idiopathic Chronic Immune-Mediated Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy -- GBS Immune Neuropathies -- Amyotrophic Lateral Sclerosis -- Epidemiology and Risk Factors -- Paraneoplastic Diseases of the Peripheral Nervous System -- Diabetic Neuropathy -- Infectious Neuropathies -- Toxic Neuropathies.
  • 2007From: CRCnetBASE
    edited by György Haskó, Bruce N. Cronstein, Csaba Szabó.
  • 2012From: Springer
    Michael E. Symonds, editor.
    1. Adipocyte Precursors: Developmental Origins, Self-Renewal, and Plasticity / Christian Dani and Nathalie Billon -- 2. Adipocyte Differentiation / José María Moreno-Navarrete and José Manuel Fernández-Real -- 3. Brown Adipose Tissue / Martin Klingenspor and Tobias Fromme -- 4. White Adipose Tissue / Stephane Gesta and C. Ronald Kahn -- 5. Sex Differences in Body Fat Distribution / Alain Veilleux and André Tchernof -- 6. Macrophages and Inflammation / Elise Dalmas, Joan Tordjman, Michèle Guerre-Millo, and Karine Clément -- 7. Adipocyte Growth and Factors Influencing Adipocyte Life Cycle / Srujana Rayalam and Clifton A. Baile -- 8. The Evolution of Mammalian Adipose Tissue / Caroline M. Pond -- 9. Dietary Determinants of Fat Mass and Body Composition / María A. Zulet, María J. Moreno-Aliaga, and J. Alfredo Martínez -- 10. The Genetic Determinants of Common Obesity-Susceptibility / Ruth J.F. Loos -- 11. Early Origins of Obesity and Developmental Regulation of Adiposity / Shalini Ojha and Helen Budge.
  • 2011From: ClinicalKey
    editors, Leonard A. Levin, Siv F.E. Nilsson, James Ver Hoeve, Samuel M. Wu ; managing editors, Paul L. Kaufman, Albert Alm.
    Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. You can also access the complete contents online at Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more.
  • 2013From: Springer
    Yoko Yamaguchi, editor.
    This book contains the Proceedings of the 3rd International Conference on Cognitive Neurodynamics held in Japan, June 9-13, 2011. It reviews the progress in this field since the first ICCN in 2007. The participants were treated to an exciting and stimulating conference that left everyone with an enthusiastic vision for the future. The discussed topics in this book include: Neural coding and realistic neural network dynamics, Neural population dynamics, Firing Oscillations and Patterns in Neuronal Networks, Brain imaging, EEG, MEG, Sensory and Motor Dynamics, Global cognitive function, Multi-scalar Neurodynamics - from Physiology to Systems Theory, Neural computing, Emerging Technologies for Brain Computer Interfaces, Neural dynamics of brain disorders.
  • 2015From: Karger
    volume editors, Anatoliy I. Yashin, Durham, NC, Michal Jazwinsk, New Orleans, La.
    Introduction to the theory of aging networks / Witten, T.M. -- Applications to aging networks / Wimble, C., Witten, T.M. -- Computational systems biology for aging research / Auley, M.T., Mooney, K.M. -- How does the body know how old it is? Introducing the epigenetic clock hypothesis / Mitteldorf, J. -- The great evolutionary divide : two genomic systems biologies of aging / Rose, M.R., Cabral, I.G., Philips, M.A., Rutledge, G.A., Phung, K.H., Mueller, L.D., Greer, L.F. -- Development and aging : two opposite but complementary phenomena / Feltes, B.C., De Faria Poloni, J., Bonatto, D. -- Aging as a process of deficit accumulation : its utility and origin / Mitnitski, A., Rockwood, K. -- Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease / Guarner, V., Rubio-Ruiz, M.E. -- Modulating mTOR in aging and health / Johnson, S.C., Sangesland, M., Kaeberlein, M., Rabinovitch, P. -- Melatonin and circadian oscillators in aging : a dynamic approach to the multiply connected players / Hardeland, R. -- Diet-microbiota-health interactions in older subjects : implications for healthy aging / Lynch, D.B., Jeffery, I.B., Cusack, S., O'Connor, E.M., O'Toole, P.W. -- Systems biology approaches in aging research / Chauhan, A., Liebal, U.W., Vera, J., Baltrusch, S., Junghanss, C., Tiedge, M., Fuellen, G., Wolkenhauer, O., Köhling, R. -- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention : do we really have an antiaging drug? / Anisimov, V.N.
  • von A. von Tschermak.
    Status: Not Checked OutLane Catalog Record
    Bd. 1. Groundlagen der allgemeinen Physiologie. T. 1. Allgemeine Charakteristik des Lebens physikalische und chemische Beschaffenheit der lebenden Substanz.
  • Ricardo Andres Valenzuela.
    Down Syndrome and Fragile X Syndrome are disorders of mental retardation that are characterized by cognitive impairments and changes to other physical characteristics. A goal in the study of these diseases has been to understand the mechanisms that underlie the cognitive impairments present in these two disorders of mental retardation. A great deal of effort has been made to study synaptic function and structure in these disorders of mental retardation in order to determine whether there are any alterations present. Alterations to synaptic structure and function present during these disorders may give insight to the neural basis of the cognitive impairments that are characteristic of this disorder of mental retardation. An area of the brain that may be affected by these disorders is the hippocampus. This area of the brain has been extensively studied for its role in memory and alterations to synaptic function and structure may underlie some of the memory deficits present in these disorders of mental retardation. Both Down Syndrome patients and Fragile X Syndrome patients have deficits in their performance on memory tests. Down Syndrome patients also have a reduction in the number of neurons present in the hippocampus (Carlesimo et al., 1997). Fragile X Syndrome patients had structural abnormalities in the hippocampus including an enlargement of ventricular spaces (Jakala et al., 1997). Synaptic function and structure in the hippocampus of mouse models of Down Syndrome and Fragile X Syndrome were studied in order to determine this region of the brain was affected. Electrophysiology recordings in area CA3 of the hippocampus of the Ts65Dn Down Syndrome mouse model indicated there were disruptions to synaptic connectivity, decreases in excitatory and inhibitory synaptic transmission, and also a reduction in intrinsic interneuron activity. Imaging studies of CA3 in the Ts65Dn mouse did not show alterations to the number of synapses or structure of synapses suggesting that the alterations found with electrophysiology recordings are the result of functional changes to synapses. Electrophysiology study of the hippocampus in mouse models of Fragile X Syndrome has shown that inhibitory function was generally intact but that excitatory axons from neurons that lacked the Fragile X Mental Retardation Protein (FMRP) were less competitive at forming synapses in a mosaic expression system of the Fmr1 gene the lack of which causes the disease. These studies indicate that alterations to synaptic structure and function are present in the hippocampus of these mouse models of mental retardation. The differences however, were not the same in Down Syndrome and Fragile X Syndrome mouse models. Nonetheless, it is possible that the changes to synaptic function found in both of these mouse models leads to altered network function in the hippocampus which may, in turn, be the underlying cause of the memory deficits present in these disorders of mental retardation. The data presented in these studies indicate that the study of these mouse models of mental retardation can give insight to alterations caused by these disorders of mental retardation which may also lead to the development of new treatments.
  • Brandon E. Johnson.
    Ion channels coordinate the movement of ions across biological membranes in response to a diversity of cellular signals to regulate most if not all aspects of physiology. The large-conductance Ca2+- and voltage-activated potassium (BK) channel is widely expressed across tissues and functions to repolarize action potentials, regulate smooth muscle tone and endocrine function, and tune auditory hair cells. In all tissues, BK channels provide a functional link between cytosolic Ca2+ and membrane excitation. Extensive alternate splicing of the slo-1 gene, encoding the BK channel, significantly diversifies channel function. We identified all twelve predicted BK channel splice variants expressed by the nematode Caenorhabditis elegans, and measured the Ca2+ and voltage dependence for each. Alternate exons encode portions of two regions of the cytoplasmic tail: the RCK domain, important for Ca2+ coordination, and an unstructured region, termed the C-linker. Using the patch clamp technique, we determined that alternate splicing across multiple sites diversifies activation kinetics and Ca2+ sensitivity by manipulating the functional interaction between the RCK domain and C-linker. We recovered two slo-1 alleles (pg34 and pg52) that contain point-mutations near an alternative splice site in the C-linker from a mutant screen. Using real-time PCR, we determined that both mutations change slo-1 splice variant expression profiles. The pg34 mutation encodes an A698T substitution, and the pg52 mutation is located in an intron. When heterologously expressed, the A698T mutation changes BK channel Ca2+ sensitivity in specific splice variant backgrounds by disrupting the functional connection between the C-linker and the RCK domain. Using in vivo electrophysiology, we determined that the pg34 mutation reduces but does not abolish BK channel function in C. elegans neurons. These results suggest that alternate splicing of slo-1 modulates the functional connection between the RCK domain and the C-linker of the BK channel to establish a proper balance between intracellular Ca2+ and membrane excitation in a variety of cell type and physiological conditions.
  • Adrienne Orr.
    Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly that is characterized by loss of short-term memory and cognitive decline. Studies in both human patients and animal models of AD point to over-accumulation of soluble oligomers of amyloid-beta peptide (Abeta) as a mediator of learning and memory impairments early in the disease (Rowan, Klyubin et al. 2005; Selkoe 2008). Support for Abeta's role in learning deficits comes from studies demonstrating impaired plasticity of synaptic inputs to neurons, as measured in the paradigm of long-term potentiation (LTP) of synaptic strength in hippocampal slices (Chen, Kagan et al. 2000; Freir, Holscher et al. 2001; Walsh, Klyubin et al. 2002; Wang, Pasternak et al. 2002; Townsend, Shankar et al. 2006), the prime candidate for the neuronal substrate of learning and memory behavior (Bliss and Collingridge 1993). Induced concurrently with synaptic LTP is an increase in the electrical coupling between the dendritic synaptic inputs and the soma, such that a greater proportion of the EPSP survives at the spike trigger zone, resulting in greater action potential output for a given EPSP. This potentiation of EPSP-spike coupling (E-S coupling) provides an additional boost to the efficacy of the EPSP on top of the potentiation (LTP) that occurs at the synapse (Bliss and Lomo 1973). While LTP of synaptic strength is an essential component of memory storage, in all models of learning, memory recall occurs only when spikes are evoked in the neurons participating in a representation. Thus E-S potentiation exerts control over the essential substrate of memory retrieval. Although LTP and E-S potentiation are mechanistically distinct processes, several features during the induction phase are shared. Studies have shown that Abeta impairs the induction, but not maintenance of LTP (Wang, Walsh et al. 2004; Townsend, Shankar et al. 2006), leaving the possibility that Abeta-mediated impairment to memory is not specific to LTP. Nevertheless, focus has centered on pathways central to LTP, while impairment to other forms of plasticity have not been explored. Here we show a mechanism by which Abeta peptides impairs post-tetanic suppression of inhibition, thereby inhibiting E-S potentiation. This impairment to E-S potentiation was occluded by GABAA-receptor, Cannabinoid 1 receptor (CB1R), and muscarinic acetylcholine receptor (mAChR), but not mGluR block. This suggests that the impairment is mediated by mAChR-initiated endocannbinoid signaling. Together, the results provide a mechanism to explain learning and memory impairments in early Alzheimer's disease.
  • 2012From: Springer
    Hans-Georg Joost, editor.
    The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control.
  • 2006From: Springer
    Michael R. Pinsky, Laurent Brochard, Jordi Mancebo, editors.
  • 2009From: Springer
    M.R. Pinsky, L. Brochard, J. Mancebo, G. Hedenstierna, (eds.).
  • 2006From: Springer
    edited by Yoshiaki Hayashida, Constancio Gonzalez and Hisatake Kondo.
    A tribute to Professor Autar Singh Paintal -- Structure of chemoreceptors -- Developmental aspects of chemoreceptors -- Molecular biology of chemoreceptors -- Biophysics of ionic channels in chemoreceptors -- Central integration and systemic effects of chemoreflex -- Mechanisms of chemoreceptions.
    Also available: Print – 2006
  • 2015From: Springer
    Chris Peers, Prem Kumar, Christopher Wyatt, Estelle Gauda, Colin A. Nurse, Nanduri Prabhakar, editors.
    Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
    Also available: Print – 2015
  • 2015From: Thieme-Connect
    Diethelm Wallwiener [and eight others].
  • 2012From: Springer
    Marco Barbero, Roberto Merletti, Alberto Rainoldi ; foreword by Gwendolen Jull.
    Part 1. Part I. -- Introduction and Applications of Surface EMG -- Basic Concepts Concerning Fields and Potential Distributions of Stationary and Moving Point Sources -- Generation, Propagation, and Extinction of Single-Fiber and Motor Unit Action Potentials -- EMG Imaging: Geometry and Anatomy of the Electrode-Muscle System -- Features of the Single-Channel sEMG Signal -- Features of the Two-Dimensional sEMG Signal: EMG Feature Imaging -- Applications of sEMG in Dynamic Conditions, Ergonomics, Sports, and Obstetrics -- Part 2. Part II. -- Trunk -- Upper Limb -- Lower Limb.
  • 2014From: Springer
    Piero Picci, Marco Manfrini, Nicola Fabbri, Marco Gambarotti, Daniel Vanel, editors.
    This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a multidisciplinary perspective, highlighting pertinent clinical, radiological, and histological correlations. Treatment is briefly reported for each entity. In addition, the more recent biomolecular findings of use for diagnosis, prognosis, and treatment are carefully analyzed. The Rizzoli case archive spans more than a century, the first treated case dating back to 28 September 1900, and contains the original material, clinical charts, imaging, paraffin blocks, and histological slides of more than 40,000 cases, including about 29,000 bone lesions and 11,000 soft tissue lesions. This book reports the most relevant entities and reflects the improvements in knowledge of musculoskeletal tumors as presented during the yearly international course held at the Rizzoli Institute.
  • 2013From: Springer
    Brian C.J. Moore, Roy D. Patterson, Ian M. Winter, Robert P. Carlyon, Hedwig E. Gockel, editors.
    Peripheral processing -- Mosaic evolution of the mammalian auditory periphery -- A computer model of the auditory periphery and its application to the study of hearing -- A probabilistic account of absolute auditory thresholds and its possible physiological basis -- Cochlear compression: Recent insights from behavioural experiments -- Improved psychophysical methods to estimate peripheral gain and compression -- Contralateral efferent regulation of human cochlear tuning: Behavioural observations and computer model simulations -- Modeling effects of precursor duration on behavioral estimates of cochlear gain -- Is overshoot caused by an efferent reduction in cochlear gain? -- Accurate estimation of compression in simultaneous masking enables the simulation of hearing impairment for normal-hearing listeners -- Modelling the distortion produced by cochlear compression -- Temporal fine structure and pitch -- How independent are the pitch and the interaural-time-difference mechanisms that rely on temporal fine structure information? -- On the limit of neural phase-locking to fine-structure in humans -- Effects of sensorineural hearing loss on temporal coding of harmonic and inharmonic tone complexes in the auditory nerve -- A glimpsing account of the role of temporal fine structure information in speech recognition -- Assessing the possible role of frequency-shift detectors in the ability to hear out partials in complex tones -- Pitch perception: Dissociating frequency from fundamental-frequency discrimination -- Pitch perception for sequences of impulse responses whose scaling alternates at every cycle -- Putting the tritone paradox into context: insights from neural population decoding and human psychophysics -- Enhancement and perceptual compensation -- Spectral and level effects in auditory enhancement -- Enhancement of increments in spectral amplitude: further evidence for a mechanism based on central adaptation -- Differential sensitivity to appearing and disappearing objects in complex acoustic scenes -- Perceptual compensation when isolated test words are heard in room reverberation -- A new approach to sound source identification -- Binaural processing -- Maps of ITD in the Nucleus Laminaris of the Barn Owl -- The influence of the envelope waveform on binaural tuning of neurons in the inferior colliculus and its relation to binaural perception -- No evidence for ITD-specific adaptation in the frequency following response -- Interaural time difference thresholds as a function of frequency -- Interaural time processing when stimulus bandwidth differs at the two ears -- Neural correlates of the perception of sound source separation -- When and how envelope "rate-limitations" affect processing of interaural temporal disparities conveyed by high-frequency stimuli -- The sound source distance dependence of the acoustical cues to location and their encoding by neurons in the inferior colliculus: implications for the Duplex theory -- Cochlear contributions to the precedence effect -- Off-frequency BMLD: the role of monaural processing -- Measuring the apparent width of auditory sources in normal and impaired hearing -- Psychophysics of human echolocation -- Speech and temporal processing -- Formant-frequency variation and its effects on across-formant grouping in speech perception -- Do we need STRFs for cocktail parties? - On the relevance of physiologically motivated features for human speech perception derived from automatic speech recognition -- Modeling speech intelligibility in adverse conditions -- Better temporal neural coding with cochlear implants in awake animals -- Effects of auditory nerve refractoriness and adaptation on auditory perception -- Robust cortical encoding of slow temporal modulations of speech -- Wideband monaural envelope correlation perception -- Detection thresholds for amplitude modulations of tones in budgerigar (Melopsittacus undulatus) -- Phase discrimination ability in Mongolian gerbils provides evidence for possible processing mechanism of mistuning detection -- Auditory cortex and beyond -- Stimulus-specific adaptation beyond pure tones -- Mapping tonotopy in human auditory cortex -- Cortical activity associated with the perception of temporal asymmetry in ramped and damped noises -- Cortical representation of the combination of monaural and binaural unmasking -- Processing of short auditory stimuli: The Rapid Audio Sequential Presentation paradigm (RASP) -- Integration of auditory and tactile inputs in musical meter perception -- A dynamic system for the analysis of the acoustic features and valence of aversive sounds in the human brain -- Auditory scene analysis -- Can comodulation masking release occur when frequency changes would promote perceptual segregation of the on-frequency and flanking bands? -- Illusory auditory continuity despite neural evidence to the contrary -- High-acuity spatial stream segregation -- How early aging and environment interact in everyday listening: From brainstem to behaviour through modeling -- Energetic and informational masking in a simulated restaurant environment -- A computational model for the dynamic aspects of primitive auditory scene analysis -- A naturalistic approach to the cocktail party -- Temporal coherence and the streaming of complex sounds.
    Also available: Print – 2013
  • 2015From: Cambridge
    David Chambers, BMBCh, MChem, DPhil, MRCP, FRCA, PGDipMedEd, Speciality Registar, Salford Royal NHS Foundation Trust, North West School of Anaesthesia, Manchester, UK, Christopher Huang, BMBCh, PhD, DM, DSc, FSB, Professor of Cell Phisiology and Fellow Director of Medical Studies, Murray Edwards College, University of Cambridge, UK, Gareth Matthews, MA, PhD, MSB, Translational Medicine and Theraputics Research Fellow, School of Clinical Medicine and Fellow in Medical Physiology, Murray Edwards College, University of Cambridge, UK.
    Section 1. The basics -- Section 2. Respiratory physiology -- Section 3. Cardiovascular physiology -- Section 4. Neurophysiology -- Section 5. Gastrointestinal tract -- Section 6. Kidney and body fluids -- Section 7. Blood and immune system -- Section 8. Energy balance -- Section 9. Endocrine physiology -- Section 10. Developmental physiology -- Section 11. Environmental physiology.
  • 2013From: Springer
    James Daniels, William W. Dexter, editors.
    Introduction -- Understanding Accreditation and Certification in Musculoskeletal Ultrasound -- Choosing Ultrasound Equipment -- Knobology -- Tissue Scanning -- Hand and Fingers -- Wrist -- Elbow -- Shoulder -- Foot and Toes -- Ankle -- Knee -- Hip -- Groin -- Ultrasound Guidance of Injections -- Rheumatologic Findings.
  • Mariel Velez.
    Polarized light plays a prominent role in shaping navigational decisions and course control in a variety of insects. Work in ants, crickets and bees have highlighted the importance of a specialized subset of ommatidia in the dorsal rim of the retina, the DRA, in detecting these signals. However, the retina's full capacity to detect polarized light has not been probed, nor are the behavioral mechanisms by which animals respond to such cues known. We have developed a novel, fully-automated behavioral paradigm for detecting polarotactic responses in Drosophila, and have used genetic and behavioral approaches to address these issues. We demonstrate that when polarized UV light stimuli are displayed to populations of Drosophila, animals align their body axis with the e-vector of plane polarized light. Surprisingly, while photoreceptors in the DRA can indeed guide this behavioral response, other photoreceptors distributed across the retinal surface can do so as well. We show that that one class of UV sensitive photoreceptors, those expressing the Rh3 opsin, is both necessary and sufficient for mediating polarotactic behavior. In particular, flies in which only Rh3 expressing photoreceptors are functional can respond to UV polarized light, while inactivation of these cells blocks polarotactic behavioral responses. Moreover, ectopic expression of a green-light sensitive opsin in Rh3 expressing cells allows flies to acquire the capacity to respond to green polarized light. Detailed behavioral studies demonstrate that the ability of flies to align to the e-vector occurs via a stereotyped modulation of the flies' rotational velocity and acceleration as a function of their angular position relative to the e-vector. These studies define the precise computations necessary to explain the behavior, and provide insight into the organization of the neural circuitry that links polarized light signals to course control.
  • 2016From: Wiley
    [edited by] R. Shane Tubbs, Mohammadali M. Shoja, Marios Loukas.
    Skull -- Hyoid bone -- Cervical vertebrae -- Thoracic vertebrae -- Lumbar vertebrae -- Sacrococcygeal vertebrae -- Scapula -- Clavicle -- Humerus -- Radius ulna carpals metacarpals and phalanges -- Ribs and sternum -- Pelvic bones -- Bones of the lower limb -- Temporomandibular joint -- Shoulder joint -- Elbow joint -- Wrist and hand joints -- Sacroiliac joints -- Hip joint -- Knee joint -- Ankle and foot joints -- Orbital muscles -- Middle ear muscles -- Facial muscles and muscles of mastication -- Anterior neck muscles -- Pharyngeal muscles -- Soft palate and tongue muscles -- Prevertebral and craniocervical junction muscles -- Laryngeal muscles -- Back muscles -- Scapulohumeral muscles -- Arm muscles -- Forearm muscles -- Hand intrinsic muscles -- Thoracic wall muscles -- Abdominal wall muscles -- Pelvic diaphragm and external anal sphincter -- Perineal muscles -- Gluteal muscles -- Thigh muscles -- Leg muscles -- Intrinsic muscles of the foot -- Internal carotid artery and anterior cerebral circulation -- Vertebrobasilar arteries -- Persistent fetal intracranial arteries -- Common carotid and cervical internal carotid arteries -- External carotid artery -- Vertebral artery -- Thoracic aorta -- Coronary arteries -- Pulmonary arteries -- Subclavian artery -- Upper limb arteries -- Abdominal aorta -- Renal arteries -- Internal iliac arteries -- Lower limb arteries -- Arteries of the spinal cord -- Diploic veins -- Dural venous sinuses -- Cerebral veins -- Emissary veins -- Veins of the neck -- Veins of the upper limb -- Intrathoracic veins -- Cardiac veins -- Pulmonary veins -- Inferior vena cava portal and hepatic venous systems -- Adrenal renal gonadal azygos hemiazygos lumbar and ascending lumbar veins -- Iliac veins -- Veins of the lower limb -- Venous drainage of the spinal cord -- Thymus -- Tonsils -- Thoracic duct chyle cistern and right lymphatic duct -- Lymphatics of the lower limb -- Forebrain -- Cerebral ventricles -- Pons medulla oblongata and cerebellum -- Subarachnoid space -- Meninges -- Spinal cord and associated structures -- Cranial nerves N-VI -- Facial nerve -- Vestibulocochlear nerve -- Glossopharyngeal nerve -- Vagus accessory and hypoglossal nerves -- Autonomic nervous system -- Spinal nerves -- Cervical plexus -- Nerves of the upper extremity -- Lumbosacral plexus -- Facial asymmetry -- Eyelids eyelashes and eyebrows -- Eye and lacrimal apparatus -- Lateral nasal wall and paranasal sinuses -- Ear -- Salivary glands and ducts -- Thyroid gland -- Parathyroid glands -- Laryngeal cartilages -- Trachea -- Lungs -- Heart -- Esophagus -- Stomach -- Gallbladder and extrahepatic bile ducts -- Liver -- Pancreas -- Spleen -- Small intestines appendix and colon -- Sigmoid colon rectum and anus -- Kidney urinary bladder and ureter -- Adrenal gland -- Male genitourinary system -- Female genital system -- Placenta and umbilical cord -- Breast.
  • 2018From: ClinicalKey
    editors, Bruce M. Koeppen, Bruce A. Stanton.
    Principles of cell and membrane function -- Homeostasis : volume and composition of body fluid compartments -- Signal transduction, membrane receptors, second messengers, and regulation of gene expression -- The nervous system : introduction to cells and systems -- Generation and conduction of action potentials -- Synaptic transmission -- The somatosensory system -- The special senses -- Organization of motor function -- Integrative functions of the nervous system -- The autonomic nervous system and its central control -- Skeletal muscle physiology -- Cardiac muscle -- Smooth muscle -- Overview of circulation -- Elements of cardiac function -- Properties of the vasculature -- Regulation of the heart and vasculature -- Integrated control of the cardiovascular system -- Introduction to the respiratory system -- Static lung and chest wall mechanics -- Dynamic lung and chest wall mechanics -- Ventilation, perfusion, and ventilation/perfusion relationships -- Oxygen and carbon dioxide transport -- Control of respiration -- Nonphysiological functions of the lung : host defense and metabolism -- Functional anatomy and general principles of regulation in the gastrointestinal tract -- The cephalic, oral, and esophageal phases of the integrated response to a meal -- The gastric phase of the integrated response to a meal -- The small intestinal phase of the integrated response to a meal -- The colonic phase of the integrated response to a meal -- Transport and metabolic functions of the liver -- Elements of renal function -- Solute and water transport along the nephron : tubular function -- Control of body fluid osmolality and volume -- Potassium, calcium, and phosphate homeostasis -- Role of the kidneys in the regulation of acid-base balance -- Introduction to the endocrine system -- Hormonal regulation of energy metabolism -- Hormonal regulation of calcium and phosphate metabolism -- The hypothalamus and pituitary gland -- The thyroid gland -- The adrenal gland -- The male and female reproductive systems.
  • editors, Bruce M. Koeppen, Bruce A. Stanton.
    Status: Not Checked OutLane Catalog Record
    Principles of cell function -- Homeostasis of body fluids -- Signal transduction, membrane receptors, second messengers, and regulation of gene expression -- The nervous system: introduction to cells and systems -- Generation and conduction of action potentials -- Synaptic transmission -- The somatosensory system -- The special senses -- Organization of motor function -- Higher functions of the nervous system -- The autonomic nervous system and its central control -- Sketetal muscle physiology -- Cardiac muscle -- Smooth muscle -- Overview of circulation -- Elements of cardiac function -- Properties of the vasculature -- Regulaiton of the heart and vasculature -- Integrated control of the cardiovascular system -- Structure and function of the respiratory system -- Mechanical properties of the lung and chest wall: static and dynamic -- Ventilation (V̇), perfusion (Q̇), and V̇/Q̇ relationships -- Oxygen and carbon dioxide transport -- Control of respiration -- Nonrespiratory functions of the lung -- Functional anatomy and general principles of regulation in the gastrointestinal tract -- The cephalic, oral, and esophageal phases of the integrated response to a meal -- The gastric phase of the integrated response to a meal -- The small intestinal phase of the integrated response to a meal -- The colonic phase of the integrated response to a meal -- Transport and metabolic functions of the liver -- Elements of renal function -- Solute and water transport along the nephron: tubular function -- Control of body fluid osmolality and volume -- Potassium, calcium, and phosphate homeostasis -- Role of the kidneys in the regulation of acid-base balance -- Introduction to the endocrine system -- Hormonal regulation of energy metabolism -- Hormonal regulation of calcium and phosphate metabolism -- The hypothalamus and pituitary gland -- The thyroid gland -- The adrenal glands -- The male and female reproductive systems.
  • 2015From: NAP
    Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Board on the Health of Select Populations, Institute of Medicine of the National Academies.
    "Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. eyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease (SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment"--Publisher's description.
  • 2008From: CRCnetBASE
    edited by Donald R. Peterson, Joseph D. Bronzino.
    Mechanics of hard tissue / J. Lawrence Katz -- Musculoskeletal soft tissue mechanics / Richard L. Lieber, Thomas J. Burkholder -- Joint-articulating surface motion / Kenton R. Kaufman, Kai-Nan An -- Joint lubrication / Michael J. Furey -- Analysis of gait / Roy B. Davis, III, Sylvia Ounpuu, Peter A. DeLuca -- Mechanics of head/neck / Albert I. King, David C. Viano -- Biomechanics of chest and abdomen impact / David C. Viano, Albert I. King -- Cardiac biomechanics / Andrew D. McCulloch -- Heart valve dynamics / Ajit P. Yoganathan, Jack D. Lemmon, Jeffrey T. Ellis -- Arterial macrocirculatory hemodynamics / Baruch B. Lieber -- Mechanics of blood vessels / Thomas R. Canfield, Philip B. Dobrin -- The venous system / Artin A. Shoukas, Carl F. Rothe -- Mechanics, molecular transport, and regulation in the microcirculation / Aleksander S. Popel, Roland N. Pittman -- Mechanics and deformability of hematocytes / Richard E. Waugh, Robert M. Hochmuth -- Mechanics of tissue/lymphatic transport / Geert W. Schmid-Schonbein, Alan R. Hargens -- Modeling in cellular biomechanics / Alexander A. Spector, Roger Tran-Son-Tay -- Cochlear mechanics / Charles R. Steele ... [et al.] -- Vestibular mechanics / Wallace Grant -- Exercise physiology / Arthur T. Johnson, Cathryn R. Dooly -- Factors affecting mechanical work in humans / Ben F. Hurley, Arthur T. Johnson.
  • 2014From: Wiley
    by Tien Tuan Dao, Marie-Christine Ho Ba Tho.
    Chapter 1. Biomechanics of the musculoskeletal system -- Chapter 2. Modeling of biomedical data uncertainty -- Chapter 3. Knowledge modeling in biomechanics of the musculoskeletal system -- Chapter 4. Clinical applications of biomechanical and knowledge-based models -- Chapter 5. Software and tools for knowledge modeling and reasoning/interference.
  • edited by Manfred Horstmanshoff, Helen King, and Claus Zittel.
    Physiologia from Galen to Jacob Bording / Vivian Nutton -- Physiological analogies and metaphors in explanations of the Earth and the cosmos / Liba Taub -- The reception of the Hippocratic treatise On glands / Elizabeth Craik -- Between atoms and humours. Lucretius' didactic poetry as a model of integrated and bifocal physiology / Fabio Tutrone -- Losing ground. The disappearance of attraction from the kidneys / Michael R. McVaugh -- The art of the distillation of 'spirits' as a technological model for human physiology. The cases of Marsilio Ficino, Joseph Duchesne and Francis Bacon / Sergius Kodera -- The body is a battlefield. Conflict and control in seventeenth-century physiology and political thought / Sabine Kalff -- Herman Boerhaave's neurology and the unchanging nature of physiology / Rina Knoeff -- The anatomy and physiology of mind. David Hume's vitalistic account / Tamás Demeter -- More than a fading flame. The physiology of old age between speculative analogy and experimental method / Daniel Schäfer -- Suffering bodies, sensible artists. Vitalist medicine and the visualising of corporeal life in Diderot / Tomas Macsotay -- Blood, clotting and the four humours / Hans L. Haak -- An issue of blood. The healing of the woman with the haemorrhage (Mark 5.24b-34; Luke 8.42b-48; Matthew 9.19-22) in early medieval visual culture / Barbara Baert, Liesbet Kusters and Emma Sidgwick -- The nature of the soul and the passage of blood through the lungs. Galen, Ibn al-Nafis, Servetus, İtaki, ʹAṭṭār / Rainer Brömer -- Sperm and blood, form and food. Late medieval medical notions of male and female in the embryology of Membra / Karine van 't Land -- The music of the pulse in Marsilio Ficino's Timaeus commentary / Jacomien Prins -- 'For the life of a creature is in the blood' (Leviticus 17:11). Some considerations on blood as the source of life in sixteenth-century religion and medicine and their interconnections / Catrien Santing -- White blood and red milk. Analogical reasoning in medical practice and experimental physiology (1560-1730) / Barbara Orland -- The "Body without Skin" in the Homeric poems / Valeria Gavrylenko -- Sweat. Learned concepts and popular perceptions, 1500-1800 / Michael Stolberg -- Of the fisherman's net and skin pores. Reframing conceptions of the skin in medicine 1572-1714 / Mieneke te Hennepe -- Vision and vision disorders. Galen's physiology of sight / Véronique Boudon-Millot -- Early modern medical thinking on vision and the camera obscura. V.F. Plempius' Ophthalmographia / Katrien Vanagt -- The Tertium comparationis of the Elementa physiologiae. Johann Gottfried von Herder's conception of "Tears" as mediators between the sublime and the actual bodily physiology / Frank W. Stahnisch -- From doubt to certainty. Aspects of the conceptualisation and interpretation of Galen's natural pneuma / Julius Rocca -- Metabolisms of the soul. The physiology of Bernardino Telesio in Oliva Sabuco's Nueva filosofía de la naturaleza del hombre (1587) / Marlen Bidwell-Steiner -- "Ful of Rapture". Maternal vocality and melancholy in Webster's Duchess of Malfi / Marion A. Wells -- The sleeping musician. Aristotle's vegetative soul and Ralph Cudworth's plastic nature / Diana Stanciu.
  • Patricia Daniels, Susan Tyler Hitchcock, Trisha Gura, Lisa Stein, John Thompson ; foreword by Richard Restak ; epilogue by Stefan Bechtel.
    Status: Not Checked OutLane Catalog Record
    Foreword / Richard Restak -- Beginnings / Patricia Daniels -- Body armor / Lisa Stein -- Structure / Lisa Stein -- Body movers / Susan Tyler Hitchcock -- Circulation / Patricia Daniels -- Vital exchange / Patricia Daniels -- Body fuel / John Thompson -- Body cleansing / John Thompson -- Control center / Patricia Daniels -- Messengers / Trisha Gura -- Reproduction / Trisha Gura -- Protection / John Thompson -- Aging / Patricia Daniels -- Epilogue: The future body / Stefan Bechtel.
  • 2010From: Karger
    volume editors, C.V. Mobbs, P.R. Hof.
    Contribution of adipose tissue to health span and longevity / Huffman, D.M., Barzilai, N. -- Obesity paradox during aging / Chapman, I.M. -- Central control of food intake in aging / Kmiec, Z. -- Changes in food intake and its relationship to weight loss during advanced age / McDonald, R.B., Ruhe, R.C. -- Changes in body composition in response to challenges during aging in rats / Wolden-Hanson, T. -- New haystacks reveal new needles : using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging / Wolkow, C.A. -- Sarcopenia : prevalence, mechanisms, and functional consequences / Berger, M.J., Doherty, T.J. -- mTOR signaling as a target of amino acid treatment of the age-related sarcopenia / D'Antona, G., Nisoli, E. -- Mitochondrial theory of aging in human age-related sarcopenia / Parise, G., De Lisio, M. -- Exercise as a calorie restriction mimetic : implications for improving healthy aging and longevity / Huffman, D.M. -- Clinical, cellular and molecular phenotypes of aging bone / Syed, F.A. ... [et al.].
  • 2013From: Springer
    Felice Eugenio Agrò, editor.
    The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice.The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.
  • 2015From: CRCnetBASE
    Jeonhee Jang.
    Body reshaping for health and beauty -- A first look at the meridian system in TCM -- Who can benefit from this treatment? -- Body posture and homeostasis -- Six body types -- Anatomical approach type M1, M2, M3 -- Muscle meridian therapy and skin cutaneous therapy -- Treatment methods -- Specific clinical cautions and application.
  • 2012From: ClinicalKey
    [editor], Andrew E. Horvai ; radiology editor, Thomas Link.
    "Save time identifying and diagnosing pathology specimens with High Yield Bone and Soft Tissue Pathology, edited by Drs. Andrew Horvai and Thomas Link. Part of the High-Yield Pathology Series, this title is designed to help you review the key pathologic features of bone and soft-tissue malformations, recognize the classic look of each disease, and quickly confirm your diagnosis. Its templated format, excellent color photographs, concise bulleted text, and authoritative content will help you accurately identify more than 160 discrete disease entities. Online access to complete text, image bank, and more at makes this an ideal reference for on-the-go pathologists."--Publisher's website.
  • 2011From: Springer
    Erol Başar.
  • 2014From: ScienceDirect
    edited by Alexander Dityatev, Bernhard Wehrle-Haller, Asla Pitkänen.
  • 2012From: ScienceDirect
    edited by Joel H. Rothman, Andrew Singson.
    An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come.
  • 2014From: Springer
    Yong-Xiao Wang, editor.
    Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells / Lin Mei, Yun-Min Zheng, and Yong-Xiao Wang -- Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter / Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, and Jennifer M. Haick -- Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells / Jun-Hua Xiao, Yong-Xiao Wang, and Yun-Min Zheng -- Large-conductance calcium-activated potassium channels / Hiroaki Kume -- Calcium-activated Chloride Channels / George Gallos and Charles W. Emala Sr. -- Local Calcium Signaling in Airway Smooth Muscle Cells / Quing-Hua Liu, Carlo Savoia, Yong-Xiao Wang -- Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices / Michael J. Sanderson -- Temporal Aspects of Ca2+ Signaling in Airway Myocytes / Etienne Roux -- Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle / Charlotte K. Billington, Ian P. Hall, and Carl P. Nelson -- Novel Mechanisms in Ca2+-homeostasis and Internal Store Refilling of Airway Smooth Muscle / Luke J. Janssen -- The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle / Philippe Delmotte, Li Jia, and Gary C. Sieck -- Role of Caveolae in the Airway / Christina M. Pabelick, Brij B. Singh, and Y.S. Prakash -- CD38 : Cyclic ADP-ribose-mediated Calcium Signaling in Airway Myocytes /Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, and Mathur S. Kannan -- The Pathways and Signaling Cross-talk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells / Lei Cai and Quinghua Hu -- Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions / Satoru Ito -- Role of Integrins in the Regulation of Calcium Signaling / Thai Tran and Chun Ming Teoh -- Sex Steroid Signaling in the Airway / Y.S. Prakash, Venkatachalem Sathish, and Elizabeth A. Townsend -- Regulation of Contractility in Immature Airway Smooth Muscle / Y.S. Prakash, Christina M. Pabelick, and Richard J. Martin -- Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells / James Sneyd, Pengxing Cao, Xiahui Tan, and Michael J. Sanderson -- Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells / Hisako Matsumoto -- Ca2+ Signaling and P2 Receptors in Airway Smooth Muscle / Luis M. Montaño, Edgar Flores-Soto, and Carlos Barajas-López -- Calcium Signaling in Airway Smooth Muscle Remodeling / Tengyao Song, Yun-min Zheng, and Yong-Xiao Wang -- Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle / Deepak A. Deshpande and Stephen B. Liggett -- Modulation of Airway Smooth Muscle Contractile Function by TNFa and IL-13 and Airway Hyper-responsiveness in Asthma / Yassine Amrani -- Airway Smooth Muscle Malfunction in COPD / Yunchao Su.
  • 2006From: CRCnetBASE
    edited by James W. Putney, Jr.
  • 2013From: Springer
    Lars Kaestner.
    Summary -- Introduction -- Direct evidence - the digital approach -- Fluorescence-based visualisation -- Aequorin-based measurements -- Measurement of calcium transport across membranes -- Molecular biology based approaches -- Manipulation of calcium -- Calcium-induced function -- Calcium signalling in cardiac myocytes -- Calcium signalling in red blood cells -- Perspective -- Calcium Signalling Methodology -- Non-linear and ultra high-speed imaging for explorations of the murine and human heart -- A system for optical high resolution screening of electrical excitable cells -- Concepts for optical high content screens of excitable primary isolated cells -- A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes -- Calcium imaging of individual erythrocytes: Problems and approaches -- Calcium Signalling in Cardiac Myocytes -- Reduced Cardiac L-Type Ca2+ Current in Cav€ 2 -/- Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation -- Overexpression of junctin causes adaptive changes in cardiac myocyte Ca2+ signaling -- Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during longterm culture -- Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement -- Calcium Signalling in Red Blood Cells -- The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation -- Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance -- Prostaglandin E2 activates channelmediated calcium entry in human erythrocytes: An indication for a blood clot formation supporting process -- Functional NMDA receptors in rat erythrocytes -- Stimulation of human red blood cells leads to Ca2+-mediated intercellular adhesion -- Lysophospatidic acid induced red blood cell aggregation in vitro -- Regulation of phosphatidylserine exposure in red blood cells -- Cation Channels in Erythrocytes - Historical and Future Perspective.
  • 2013From: Springer
    Bohuslav Ostadal, Naranjan S. Dhalla, editors.
    The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to [alpha]-adrenoceptor and [beta]-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
  • 2013From: Springer
    Bodh I. Jugdutt, Naranjan S. Dhalla, editors.
    The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
  • 2009From: Springer
    Mogens L. Glass, Stephen C. Wood, editors.
    Overview of the respiratory system / S.C. Wood -- Control of respiration in aquatic vertebrates: Gas transport and gill function in water-breathing fish / S.F. Perry ... [et al.]. Patterns of acid-base regulation during exposure to hypercarbia in fishes / C.J. Brauner and D.W. Baker. Buoyancy control in aquatic vertebrates / B. Pelster. Gas exchange and control of respiration in air-breathing teleost fish / M.L. Glass and F.T. Rantin. Effects of temperature on cardiac function in teleost fish / A.L. Kalinin ... [et al.]. Physiological evidence indicates lungfish as a sister group to the land vertebrates / M.L. Glass. Aestivation in amphibians, reptiles, and lungfish / M.L. Glass, J. Amin-Naves, and G.S.F. da Silva -- Evolution of pulmonary mechaincs and respiratory control: Trade-offs in the evolution of the respiratory apparatus of chordates / S.F. Perry, W. Klein, and J.R. Codd. Environmental selection pressures shaping the pulmonary surfactant system of adult and developing lungs / S. Orgeig and C.B. Daniels. Midbrain structures and control of ventilation in amphibians / L.H. Gargaglioni and L.G.S. Branco. Comparative aspects of hypoxia tolerance of the ectothermic vertebrate heart / H. Gesser and J. Overgaard. Control of the heart and of cardiorespiratory interactions in ectothermic vertebrates / E.W. Taylor and T. Wang. The endocrine-paracrine control of the cardiovascular system / B. Tota and M.C. Cerra. Stoking the brightest fires of life among vertebrates / Raul K. Suarez and Kenneth C. Welch -- Respiratory physiology of birds : metabolic control: Prenatal development of cardiovascular regulation in avian species / J. Altimiras, D.A. Crossley II, and E. Villamor. Control of breathing in birds : implications for high-altitude flight / G.R. Scott and W.K. Milsom -- Mammalian and human physiology: Peripheral chemoreceptors in mammals : structure, function and transduction / P. Kumar. Central chemosensitivity in mammals / L.K. Hartzler and R.W. Putnam. Human exercise physiology / S. Volianitis and Niels H. Secher.
  • 2010From: AccessMedicine
    David E. Mohrman, Lois Jane Heller.
  • 2014From: AccessMedicine
    David E. Mohrman, PhD, Lois Jane Heller, PhD.
    Overview of the cardiovascular system -- Characteristics of cardiac muscle cells -- The heart pump -- Measurements of cardiac function -- Cardiac abnormalities -- The peripheral vascular system -- Vascular control -- Hemodynamic interactions -- Regulation of arterial pressure -- Cardiovascular responses to physiological stresses -- Cardiovascular function in pathological situations -- Answers to study questions.
  • 2010From: CRCnetBASE
    Lynne Berdanier, Carolyn D. Berdanier.
    "Today's knowledge of human health demands a multidisciplinary understanding of medically related sciences, and Case Studies in the Physiology of Nutrition answers the call. Dedicated to the integration of nutrition science with physiology, this text cohesively incorporates descriptions of human problems in order to stimulate students' critical thinking about how the body integrates various physiological factors to maintain homeostasis. This textbook uses short story-type case studies about fictional individuals who have health problems in order to address a range of issues in an approachable manner. The studies vary in difficulty, with some being straightforward with very simple answers, while others require in-depth thinking and literature research to solve. Each study presents patient background, symptoms, clinical finding, and questions to ponder. Upon qualifying course adoption, this book also includes a valuable instructor's manual, which provides solutions to exercises, problem analysis, and resolution to each case study."--Publisher's description.
  • 2006From: Springer
    Philipp Kaldis (ed.).
    Also available: Print – 2006
  • 2012From: Springer
    [edited by] Livio Luzi.
    1. Human Evolution and Physical Exercise: The Concept of Being "Born to Run" / Livio Luzi -- 2. Cell Morphology and Function: The Specificities of Muscle Cells / Anna Maestroni -- 3. The Cell Membrane of the Contractile Unit / Gianpaolo Zerbini -- 4. Gene Polymorphisms and Athletic Performance / Ileana Terruzzi -- 5. Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise / Stefano Benedini -- 6. Mitochondrial and Non-mitochondrial Studies of ATP Synthesis / Roberto Codella -- 7. Excessive Nutrients and Regional Energy Metabolism / Gianluca Perseghin -- 8. Muscle Biopsy To Investigate Mitochondrial Turnover / Rocco Barazzoni -- 9. Introduction to the Tracer-Based Study of Metabolism In Vivo / Andrea Caumo and Livio Luzi -- 10. Physical Activity and Inflammation / Raffaele Di Fenza and Paolo Fiorina -- 11. The HPA Axis and the Regulation of Energy Balance / Francesca Frigerio -- 12. Physical Exercise in Obesity and Anorexia Nervosa / Alberto Battezzati and Simona Bertoli -- 13. Physical Exercise and Transplantation / Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi -- 14. The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise / Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.
  • 2012From: ClinicalKey
    edited by Mordecai P. Blaustein, Joseph P.Y. Kao, Donald R. Matteson.
    Introduction : homeostasis and cellular physiology -- Diffusion and permeability -- Osmotic pressure and water movement -- Electrical consequences of ionic gradients -- Ion channels -- Passive electrical properties of membranes -- Generation and propagation of the action potential -- Ion channel diversity -- Electrochemical potential energy and transport processes -- Passive solute transport -- Active transport -- Synaptic physiology I -- Synaptic physiology II -- Molecular motors and the mechanism of muscle contraction -- Excitation-contraction coupling in muscle -- Mechanics of muscle contraction.
  • 2012From: Springer
    Brian Henderson, A. Graham Pockley, editors.
    Section 1 Historical Introduction to Secreted Cell Stress Proteins as Signalling Proteins -- Discovery of the Cellular Secretion of Cell Stress Proteins -- Discovery of the Agonist Activities of Molecular Chaperones and Protein-Folding Catalysts -- Identification of Cell Stress Proteins in Biological Fluids -- Section 2 Intracellular Trafficking of Molecular Chaperones and its Consequences -- Hsp27 Phosphorylation Patterns and Cellular Consequences -- Evidence on Cholesterol-Controlled Lipid Raft Interaction of the Small Heat Shock Protein HSPB11 -- Hsp70 Chaperone Systems in Vesicular Trafficking -- Pathways of Hsp70 Release: Lessons from Cytokine Secretion -- Nucleolin: A Novel Intracellular Transporter of HSPA1A -- The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control -- Section 3 Molecular Chaperones as Cell Surface Receptors and Receptor Ligands -- Cell Surface Molecular Chaperones and the LPS Receptor -- Hsp60: An Unexpected Cell Surface Receptor in Prokaryotes and Eukaryotes -- Pathophysiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)-based Macromolecules and Nanotherapeutics to Solid Tumors -- The Chaperokine Activity of HSPA1A -- Molecular Chaperones and Scavenger Receptors: Binding and Trafficking of Molecular Chaperones by Class F and Class H Scavenger Receptors -- Grp78 (BiP): A Multifunctional Cell Surface Receptor -- Section 4 Extracellular Secretion of Molecular Chaperones in Prokaryotes and Eukaryotes -- Mycobacterium Tuberculosis Hsp60 as a Key Virulence Factor in Tuberculosis -- Hsp90 vs Conventional Growth Factors in Acute and Diabetic Wound Healing -- Circulating Molecular Chaperones in Health and Disease -- Index.
  • 2014From: ScienceDirect
    edited by Narender Ramnani.
    Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biologi
  • 2015From: Thieme-Connect
    Juergen Freyschmidt ; translator, Terry C. Telger.
  • 2014From: Springer
    Louis-Cyril Celestin.
    Genius and dilettantism often go hand in hand. Nowhere is this truer than in the life of Charles-Edouard Brown-Sequard, the bilingual physician and neurologist who succeeded Claude Bernard as the Chair of Experimental Medicine at the College de France in Paris after having practiced in Paris, London and in the USA, especially in Harvard. For most men, making one discovery of global importance would have sufficed to satisfy their curiosity and self-image. Not so Brown-Sequard. His explanation of the neurological disparity following the hemi-section of the spinal cord was a unique achievement that added his name to the syndrome and made him immortal. Yet, the demons of his mind tormented him in his endless search for medical truths and drove him to explore other phenomena, seeking to explain and remedy them. This unique biography shows for the first time the conflict between his professional and personal life, and should appeal to all students of medical history and psychology.
  • 2006From: Springer
    Brehon C. Laurent (ed.).
    Also available: Print – 2006
  • 2012From: Atypon
    Donald McEachron.
    This book represents the first in a two-volume set on biological rhythms. This volume focuses on supporting the claim that biological rhythms are universal and essential characteristics of living organisms, critical for proper functioning of any living system. The author begins by examining the potential reasons for the evolution of biological rhythms: (1) the need for complex, goal-oriented devices to control the timing of their activities; (2) the inherent tendency of feedback control systems to oscillate; and (3) the existence of stable and powerful geophysical cycles to which all organisms must adapt. To investigate the second reason, the author enlists the help of biomedical engineering students to develop mathematical models of various biological systems. One such model involves a typical endocrine feedback system. By adjusting various model parameters, it was found that creating a oscillation in any component of the model generated a rhythmic cascade that made the entire system oscillate. This same approach was used to show how daily light/dark cycles could cascade rhythmic patterns throughout ecosystems and within organisms.
  • 2013From: Springer
    Kerry L. Tucker, Tamara Caspary, editors.
    Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as 'antennae' for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
  • 2005From: ScienceDirect
    edited by Michael W. Young.
    Genetic approaches to circadian clocks -- Tracking circadian control of gene activity -- Molecular cycles : clock protein rhythms -- Anatomical representation of neural clocks -- Mosaic circadian systems -- Peripheral circadian clocks -- Cell and tissue culture system -- Intercellular signaling -- Photoresponsive clocks -- Sleeping flies -- Circadian biology of populations -- Circadian clocks affecting noncircadian biology.
    Also available: Print – 2005
  • 2011From: ScienceDirect
    Leon Chaitow, Judith DeLany.
    Clinical Application of Neuromuscular Techniques, Volume 2 - The Lower Body discusses the theory and practice of the manual treatment of chronic pain, especially with regards to the soft tissues of the lower body.
  • Puneet K. Gupta, MD, MSE, Assistant Professor, Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, Pradeep Modur, MD, MS, Associate Professor, Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, Srikanth Muppidi, Clinical Assistant Professor, Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California.
    Status: Not Checked OutLane Catalog Record
    Anatomy and physiology -- Electronics and instrumentation -- Nerve conduction studies and electromyography (EMG) -- Electroencephalography (EEG) -- Evoked potentials and intraoperative monitoring (IOM) -- Polysomnography and other sleep studies (PSG) -- Advanced topics : high frequency oscillations (HFOs), DC shifts, transcranial electrical stimulation (TES), motor evoked potential (MEP), transcranial magnetic stimulation (TMS), magnetoencephalopgraphy (MEG), autonomic testing, blink reflex, single fiber EMG (SFEMG), quantitative EEG (QEEG) -- Ethics and safety.
  • Robert W. Baloh, Kevin A. Kerber.
    Status: Not Checked OutLane Catalog Record
    Overview of the vestibular system anatomy and physiology -- The peripheral vestibular system -- The central vestibular system -- Epidemiology of dizziness -- The history of the dizzy patient -- Bedside examination of the vestibular system -- Laboratory examinations of the vestibular system -- Clinical evaluation of hearing -- Infectious diseases -- Benign positional vertigo -- Endolymphatic hydrops (Meniere's syndrome) -- Migraine -- Immune-mediated diseases -- Vascular disorders -- Tumors -- Trauma -- Toxic/metabolic disorders -- Developmental and genetic disorders -- Antiemetic and antivertigo drugs -- Vestibular rehabilitation.
  • Aaron Berkowitz.
    Status: Not Checked OutLane Catalog Record
    The cardiovascular system -- The pulmonary system -- The renal system -- The gastrointestinal system -- The endocrine system -- The hematologic system -- The nervous system -- Rheumatology -- Male and female reproductive systems -- Cases.
  • Roberts, Kathleen E.
    Status: Not Checked OutLane Catalog Record
  • Stephen Goldberg.
    Status: Not Checked OutLane Catalog Record
    Chapter 1. Cell function -- Chapter 2. Blood pressure -- Chapter 3. Electrolytes and acid-base metabolism -- Chapter 4. Evaluation of renal function -- Chapter 5. Evaluation of cardiac function -- Chapter 6. The respiratory system -- Chapter 7. Blood cells and blood coagulation -- Chapter 8. The immune system -- Chapter 9. Neurophysiology -- Chapter 10. The digestive system -- Chapter 11. The endocrine system.
  • 2008From: Thieme Book
    Klaus Buckup.
    The mainstay of orthopedic diagnosis continues to be the physical examination of the patient following a thorough history. This convenient pocketbook presents a comprehensive collection of the clinical tests that are used in orthopedic diagnosis, thereby answering the following questions: What tests are available for examining a particular joint, and how are they to be interpreted? What is meant by the name of a test that is mentioned in the literature or in a physician's report? The methodology and interpretation of all relevant test procedures are presented in almost 500 instructive drawings and brief descriptions: Initial tests, Functional tests, Stress tests, Stability tests. Tables on the examination of the spinal column, shoulder joint, and knee joint help in selecting the most suitable examinations. An invaluable aid for physical therapists, orthopedic surgeons, and primary care or emergency room physicians.
  • 2016From: Thieme Book
    Klaus Buckup, MD ; Johannes Buckup, MD [Translator: Alan Wiser].
    Spine -- Shoulder -- Elbow -- Wrist, hand, and fingers -- Hip -- Knee -- Foot and ankle -- Posture deficiency -- Venous thrombosis -- Occlusive arterial disease and neurovascular compression syndromes -- Disturbances of the central nervous system.
  • 2007From: Cold Spring Harb Lab Press
    meeting organized by Bruce Stillman, David Stewart, and Terri Grodzicker.
    Introduction -- Clockworks -- Posttranscriptional and posttranslational mechanisms -- Genetics of rhythms -- Entrainment and peripheral clocks -- Systems approaches to biological clocks -- Models -- Development, proliferation, and aging -- Neuroanatomy and circuits -- Sleep, seasons, and mood.
  • 2014From: Thieme
    Werner Platzer ; illustrations by Gerhard Spitzer.
    The body -- The Cell -- Tissues -- General features of the skeleton -- General features of the muscles -- Anatomical terms and their Latin equivalents -- Trunk -- Anatomical terms and their Latin equivalents -- Upper Limb -- Bones, ligaments and joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Lower Limb -- Bones, ligaments, joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Head and Neck -- Skull -- Muscles and fascias -- Anatomical terms and their Latin equivalents -- Topography of peripheral nerves and vessels -- Head and neck -- Upper limb -- Trunk -- Lower limb -- Anatomical terms and their Latin equivalents.
  • 2010From: Thieme Book
    Stefan Silbernagl, Florian Lang ; illustrations by Rüdiger Gay and Astried Rothenburger.
    Fundamentals -- Temperature, energy -- Blood -- Respiration, acid-base balance -- Kidney, salt and water balance -- Stomach, intestines, liver -- Heart and circulation -- Metabolism -- Hormones -- Neuromuscular and sensory systems.
  • Stefan Silbernagl, Agamemnon Despopoulos ; color plates by Ruediger Gay and Astried Rothenburger.
    Status: Not Checked OutLane Catalog Record
    Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
  • 2015From: Thieme
    Stefan Silbernagl, Agamemnon Despopoulos ; color plates by Ruediger Gay and Astried Rothenburger ; translator: Geraldine O'Sullivan.
    Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
  • 2008From: CRCnetBASE
    edited by James R. Brown.
    Introduction : the broad horizons of comparative genomics / James R. Brown -- Advances in next-generation DNA sequencing technologies / Michael L. Metzker -- Large scale phylogenetic reconstruction / Bernard M.E. Moret -- Comparative genomics of viruses using bioinformatics tools / Chris Upton and Elliot J. Lefkowitz -- Archaebacteria and the prokaryote-to-eukaryote transition (and the role of mitochondria therein) / William Martin, Tal Dagan, and Katrin Henze -- Comparative genomics of invertebrates / Takeshi Kawashima ... [et al.] -- Comparative vertebrate genomics / James W. Thomas -- Gaining insight into human population-specific selection pressure / Michael R. Barnes -- Comparative genomics in drug discovery / James R. Brown -- Comparative genomics and the development of novel antimicrobials / Diarmaid Hughes -- Comparative genomics and the development of antimalarial and antiparasitic therapeutics / Emilio F. Merino, Steven A. Sullivan, and Jane M. Carlton -- Comparative genomics in AIDS research / Philippe Lemey, Koen Deforche, and Anne-Mieke Vandamme -- Detailed comparisons of cancer genomes / Timon P.H. Buys ... [et al.] -- Comparative cancer epigenomics / Alice N.C. Kuo ... [et al.] -- G protein-coupled receptors and comparative genomics / Steven M. Foord -- Comparative toxicogenomics in mechanistic and predictive toxicology / Joshua C. Kwekel, Lyle D. Burgoon, and Tim R. Zacharewski -- Comparative genomics and crop improvement / Michael Francki and Rudi Appels -- Domestic animals : a treasure trove for comparative genomics / Leif Andersson.
  • 2014From: Springer
    Erika Jensen-Jarolim, editor.
    This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
  • 2012From: Springer
    Marshall D. McCue, editor.
    An introduction to fasting, starvation, and food limitation / Marshall D. McCue -- A history of modern research into fasting, starvation, and inanition / Jean-Hervé Lignot and Yvon LeMaho -- Starvation in rotifers : physiology in an ecological context / Kevin L. Kirk -- Drosophila as a model for starvation : evolution, physiology, and genetics / Alen G. Gibbs and Lauren A. Reynolds -- Metabolic transitions during feast and famine in spiders / Johannes Overgaard and Tobias Wang -- Adaptation of the physiological, endocrine, and digestive system functions to prolonged food deprivation in fish / Nadav Bar and Helene Volkoff -- Starvation in subterranean species versus surface-dwelling species : crustaceans, fish, and salamanders / Frédéric Hervant -- Physiological responses to starvation in snakes : low energy specialists / Marshall D. McCue, Harvey B. Lillywhite, and Steven J. Beaupre -- Cardiovascular circuits and digestive function of intermittent-feeding sauropsids / Rike Campen and Matthias Starck -- Thermoregulatory adaptations to starvation in birds / Esa Hohtola -- Fasting in birds : general patterns and the special case of endurance flight / Susanne Jenni-Eiermann and Lukas Jenni -- Tissue-specific mass changes during fasting : the protein turnover hypothesis / Ulf Bauchinger and Scott R. McWilliams -- Seasonal changes in body mass and energy balance in wild small mammals / Xueying Zhang, Xinyu Liu, and Dehua Wang -- Changes in form and function of the gastrointestinal tract during starvation : from pythons to rats / Jehan-Hervé Lignot -- Changes in fatty acid composition during starvation in vertebrates : mechanisms and questions / Edwin R. Price and Teresa G. Valencak -- Physiological responses to fasting in bats / Miriam Ben-Hamo, Agustí Muñoz-Garcia, and Berry Pinshow -- Muscle protein and strength retention by bears during winter fasting and starvation / Hank Harlow -- Seasonal starvation in northern white-tailed deer / Duane E. Ullrey -- Fasting physiology of the pinnipeds : the challenges of fasting while maintaining high energy expenditure and nutrient delivery for lactation / Cory D. Champagne ... [et al.] -- The use and application of stable isotope analysis to the study of starvation, fasting, and nutritional stress in animals / Kent A. Hatch -- Fearing the danger point : the study and treatment of human starvation in the United Kingdom and India, c. 1880-1974 / Kevin Grant -- Quantitative physiology of human starvation : adaptations of energy expenditure, macronutrient metabolism, and body composition / Kevin D. Hall -- Alternate day fasting : effects on body weight and chronic disease risk in humans and animals / Krista A. Varady -- Horizons in starvation research/ Marshall D. McCue.
  • 2009From: Springer
    edited by Syamal K. Dana, Prodyot K. Roy, Jürgen Kurths.
  • 2011-From: Wiley
    "Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled. Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. With the launch of Comprehensive Physiology in January 2011, we will begin publishing regular issues that update and expand the classic content from HoP, as well as adding fresh review material. In this way, we aim to capture the full breadth and depth of the evolving science of physiology. New and updated materials will be published in a quarterly serial format ... The primary audience for Comprehensive Physiology is academic scientists in the life sciences. Secondary audiences include advanced students in the life sciences and medicine, instructors in these disciplines, and academic clinicians"--Edited summary from home page.
  • 2014From: ScienceDirect
    edited by Zhongmin Jin.
    1. Fundamentals of computational modelling of biomechanics in the musculoskeletal system -- 2. Finite element modeling in the musculoskeletal system: generic overview -- 3. Joint wear simulation -- 4. Computational modeling of cell mechanics -- 5. Computational modeling of soft tissues and ligaments -- 6. Computatonal modeling of muscle biomechanics -- 7. Computational modelling of articular cartilage -- 8. Computational modeling of bone and bone remodeling -- 9. Modelling fracture processes in bones -- 10. Modelling fatigue of bone cement -- 11. Modelling fracture processes in orthopaedic implants -- 12. Modelling cementless cup fixation in total hip arthroplasty (THA) -- 13. Computational modeling of hip implants -- 14. Computational modelling of knee implants -- 15. Computational modelling of spinal implants -- 16. Finite element modelling of bone tissue scaffolds -- Index.
  • Lampros C. Kourtis.
    A new method to evaluate bone rigidity and strength using tomographic bone images obtained via QCT (Quantitative Computed Tomography) is introduced. A newly developed computer program named VA-BATTS is used for image processing, bone segmentation, mesh creation, material assignment and calculation of far field normal and shear stresses as well as other cross sectional properties. In order to calculate torsional and transverse shear stresses in prismatic bodies having inhomogenous material properties, a new two-dimensional finite element formulation to estimate is presented. The formulation combines the torsional and transverse shear problem solutions and adds terms to account for the material inhomogeneity into one Weak Form of the problem, further discretized to yield a numerical approximation of the shear stresses problem. Results were validated using analytical models as well as three dimensional commercial code test cases yielding mean errors over the entire domain of less than 1%. This semi-automated application is publicly distributed and can be downloaded from VA-BATTS implements an elliptical stress failure criterion to predict bone strength. To validate, fifty-two fresh frozen femurs were tested under combined three-point bending and torsion to failure. VA-BATTS was able to predict bone failure under combined bending and torsion (R2=0.68) as well as bone torsional (R2=0.80) and bending (R2=0.50) rigidity. Using multivariate analysis that combined the elliptical stress failure and the torsional and bending rigidities, the prediction confidence level was raised (R2=0.87), comparable to existing more complex three dimensional finite element studies. The elliptical stress criterion suggests that the distal femur is weaker, in absolute terms, than the midshaft femur suggesting an explanation of the increased rate of distal femur fractures in patients with Spinal Cord Injury. In general, the newly introduced method proved to yield more accurate predictions compared to DXA derived Bone Mineral Density measurements (R2=0.56). Fracture patterns were analyzed to show mostly spiral patterns where torsional loads were applied. In addition, the accuracy of three point bending experiments was examined. Three parameters that may introduce errors in the predictions - transverse shear, local deformation (indentation) as well as cross sectional deformation effect -- were studied using a parametric finite element model. The model shows that depending on the geometric properties of the bone, errors as high as 75% may be introduced in the estimation of the bone elastic modulus. Bone rigidity estimates may now be corrected using the correction factors supplied in this study.
  • Edith Merle Arnold.
    Walking and running rely on the complex coordination of the neurological, muscular, and skeletal systems. The role of muscles in this system is to produce force, a task that is dramatically affected by the dynamics of muscle fibers. In walking and running, we do not know how fiber dynamics affect force generation because experimental tools are ill suited to these measurements. Computer models can be powerful tools for estimating muscle dynamics that cannot be measured experimentally. During my doctoral research I created a model based on state-of-the-art muscle architecture data that estimates fiber lengths and velocities during movement. I used this model to create simulations of muscle fiber dynamics for five subjects walking and running at multiple speeds. Analysis of my simulations revealed how walking or running speed affects force generation, explained how running enables some muscles to produce more force than they do in walking, and yielded normative muscle fiber lengths and velocities of eleven muscles during walking and running. The results support the hypothesis that the walk-to-run transition in human gait is related to the force generation ability of the plantarflexors, offer insights into dynamic properties of muscles that have not yet been measured during walking and running, and permit comparisons among muscles with diverse architecture. The model and simulations created as part of this work can be applied to many other research areas in biomechanics and have been made freely available at
  • 2015From: ScienceDirect
    edited by Shane O'Mara and Marian Tsanov.
    1. If I had a million neurons: potential tests of cortico-hippocampal theories -- 2. Diluted connectivity in pattern association networks facilitates the recall of information from the hippocampus to the neocortex -- 3. Cortico-hippocampal systems involved in memory and cognition: the PMAT framework -- 4. The subiculum: the heart of the extended hippocampal system -- 5. The neural correlates of navigation beyond the hippocampus -- 6. Septo-hippocampal signal processing: breaking the code -- 7. Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function -- 8. Importance of the ventral midline thalmas in driving hippocampal functions -- 9. The mammillary bodies and memory: more than a hippocampal relay -- 10. Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions -- 11. Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding -- Index.
  • Greg Maness Allen.
    The actin-based crawling motility of eukaryotic cells is a vital example of emergent cellular behavior arising from the mechanical output of thousands to millions of individual chemical reactions occurring every second. In this work, I describe a set of experimental and analytical results that seek to reveal the underlying organization and operations of this micron sized biological machine. We found that the morphology of crawling cells is quantitatively dictated by the cytoskeletal elements that produce motility. Each cell is unique in its organization and behavior, and across a population of cells this variation could largely be reduced to a single dimension. Globally perturbing the biochemical reaction rates that drive motility with changes in temperature forced individual cells out of their steady state behavior along this same single dimension of variation. In addition individual cells fluctuated harmonically around their steady state behavior, suggesting a mechanical oscillator arising from the coupling of the processes of actin meshwork assembly and disassembly. Flickers of elevated intracellular concentration of the canonical secondary messenger calcium were seen, but these calcium flickers were not required for cell motion nor were they correlated with any measured change in cell behavior. The orientation of motion, similar to the rate of motion, is directly coupled to the cytoskeletal organization and cellular shape. To change their direction of migration, cells develop asymmetries in the interwoven actions of myosin contractility and adhesion to the substrate at the rear of the cell creating asymmetric centripetal actin flow. This system of controlling orientation was responsive to external cues from electric fields secondary to electrophoretic redistribution of charged membrane components extending into the extracellular space.
  • David B. Kastner.
    Adaptation provides a ubiquitous strategy for neural circuits to encode their inputs using their limited dynamic range within the variety of sensory environments that they encounter. However, because of the inherent timescale necessary to optimize the response properties of a cell to its environment, any form of adaptive plasticity can cause a neuron to fail to encode the stimulus when the environment changes. Many ganglion cells, the output neurons of the retina, adapt so as to lower their sensitivity in an environment of high contrast, but if the contrast subsequently decreases the cell will fall below threshold and fail to signal. I have found a distinct form of plasticity within the retina that acts in coordination with the process of adaptation. Cells using this new form of plasticity elevate their sensitivity after a transition to low contrast. This process, called sensitization, occurs in retinas from multiple species. Multielectrode recordings from sensitizing and adapting cells indicate that both populations encode the same visual signals. The complementary action of the two populations helps the retina encode its input over a broader range of signals and environmental changes, with one population continuing to respond when the other fails. The threshold placement of these two cell types further enhances their coordination because sensitizing cells maintain lower thresholds, while adapting cells maintain higher thresholds. Using a theoretical model, I was able to show that this behavior maximized the amount of information that the two populations can provide about their input. I have further studied the spatiotemporal region that controlled the sensitivity of a cell--the adaptive field. Just as retinal circuitry uses excitation and inhibition to form biphasic center-surround receptive fields, the retina can also use adaptation and sensitization to form biphasic adaptive fields in both the spatial and temporal domains. Since visual statistics are correlated across time and space, center-surround biphasic receptive fields more efficiently encode the input by subtracting a prediction of the stimulus so as to just encode the deviation from that prediction. Biphasic adaptive fields appear to perform an opposite function, transmitting a prediction of the stimulus at the transition of a stimulus environment to weaker signals. This assists in the encoding of an uncertain environment by storing features of a predictable input. A model indicates that sensitization within the adaptive field can be produced by adapting inhibition, a form of plasticity whose function was previously unknown. Using pharmacology, I confirmed this prediction, showing that GABAergic inhibition is necessary for sensitization. Using simultaneous intracellular recording from inhibitory amacrine cells and multielectrode recording from ganglion cells, I show that transmission from a single amacrine cell is sucient to cause sensitization. Using a novel approach to analyze a circuit, I quantitatively describe the changes in amacrine cell transmission that underlie sensitization thus elucidating how the retina performs this sophisticated computation.
  • 2012From: Springer
    Robert Chen, John C. Rothwell, editors.
    The study and modulation of cortical connections is a rapidly growing area in neuroscience. This unique book by prominent researchers in the field covers recent advances in this area. The first section of the book describes studies of cortical connections, modulation of cortical connectivity and changes in cortical connections with activities such as motor learning and grasping in primates. The second section covers the use of non-invasive brain stimulation to study and modulate cortical connectivity in humans. The last section describes changes in brain connectivity in neurological and psychiatric diseases, and potential new treatments that manipulate brain connectivity. This book provides an up-to-date view of the study of cortical connectivity, and covers its role in both fundamental neuroscience and potential clinical applications.
  • 2013From: Springer
    Linda K. McLoon, Francisco Andrade, editors.
    Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereotype.This book is the most comprehensive reference to date on craniofacial muscle development, structure, function, and disease. It details the state-of-the-art basic science of the craniofacial muscles, and describes their unique response to major neuromuscular conditions. Most importantly, the text highlights how the craniofacial muscles are different from most skeletal muscles, and why they have been viewed as a distinct allotype. In addition, the text points to major gaps in our knowledge about these very important skeletal muscles and identified key gaps in our knowledge and areas primed for further study and discovery.
  • 2007From: CRCnetBASE
    edited by, Joseph A. Beavo, Sharron H. Francis, and Miles D. Houslay.
  • Jacob Rinaldi.
    This thesis is composed of experimental and analytic work deconstructing the cerebellar learning algorithm. The central finding is that two parallel neural circuits, with independent instructive signals, support cerebellum-dependent learning. An analytic framework for this result, based on overcoming signal-dependent noise, is proposed.
  • James Francis Nishimuta.
    Osteoarthritis is a debilitating disease that affects 27 million Americans. Major risk factors for osteoarthritis include mechanical injury and obesity. Prolonged exposure to mechanical overload in the knee joint, either by injury, malalignment, or obesity, is associated with early onset of osteoarthritis. Recent evidence demonstrates that adipose tissue is a metabolically active and produces systemic biofactors known as adipokines associated with numerous diseases including cardiovascular disease, hypertension, insulin resistance, rheumatoid arthritis, and osteoarthritis. Interestingly, obesity is a significant risk factor for hand osteoarthritis, suggesting a biologic link between obesity and osteoarthritis that is perhaps mediated through adipokines. While many studies investigating in vitro osteoarthritic degradation have focused on cartilage tissue, the menisci has received relatively little attention despite it's important functional role in joint stability and load transfer in the knee. The purpose of this thesis was to explore the relative susceptibility of cartilage and meniscal tissue degradation to in vitro mechanical overload and adipokine exposure using an immature bovine tissue explant model. To explore the injury response, explants of cartilage and meniscal tissues were compressed at various strain rates to create a spectrum of peak injury forces and cultured for up to nine days post-injury. To investigate whether adipose tissue and adipokines can biochemically induce changes in cartilage and meniscal tissues, explants of cartilage and meniscal tissue were incubated with infrapatellar fat pad or individual adipokines and assessed for altered matrix metabolism. Overall, results indicate that, while mechanically robust, meniscal tissue is vulnerable to biologic damage induced by mechanical overload and adipokines. We also demonstrate for the first time that meniscal tissue is more catabolically sensitive to adipokines than cartilage tissue. These results provide evidence that obesity-driven degradation of knee joint could be biochemically mediated and suggest meniscal degradation as a possible early event in osteoarthritis development.
  • Erik Michael Lehnert.
    Coral reefs are animal-built structures that provide habitats for a disproportionately large number of marine species relative to the small percentage of the ocean that they cover. Corals, and some other cnidarians such as anemones, host dinoflagellates within the cells of their gastrodermal tissue. The dinoflagellates fix carbon photosynthetically and transfer it to the host; the dinoflagellates can provide up to 90% of the hosts' metabolic requirements. The symbiosis between the cnidarian host and its dinoflagellate symbiont is therefore the trophic foundation on which coral reef are built. Despite its importance, the molecular mechanisms controlling symbiosis establishment, maintenance, and breakdown remain poorly understood. Our lab is working to further develop the small sea anemone, Aiptasia, as a model system for studying cnidarian-dinoflagellate symbiosis. To this end, I sequenced the transcriptome of aposymbiotic Aiptasia, of symbiotic Aiptasia, and of the dinoflagellate symbionts. I then used these resources to perform gene-expression analysis comparing symbiotic and aposymbiotic anemones, which provided numerous testable biological hypotheses about both the structural basis of the symbiosis and the downstream metabolic effects of metabolite transfer to the host. These resources should serve as the foundation for future experiments in our laboratory and more widely in the field of coral biology.
  • Joshua P. Ferreira.
    Cancer arises from the alteration of genes and the deregulation of the inherent control mechanisms existing with a cell. Cancer progression is the result of several of these genes or pathways being altered. Unfortunately, its analysis is not as straightforward as identifying a handful of discrete, independent mutational events occurring within a cell. Rather, these genes, pathways, and other regulatory elements are interconnected. Altering the expression level (dose) of one gene can have direct and indirect effects on many additional genes/pathways. Furthermore, combinations of genes can interact to have collaborative or antagonistic effects that are greater than or less than the sum of their individual contributions. It is not enough to study the effects of single genes/pathways at a few discrete expression levels. To this end, we have developed genetic tools that allow for controlling gene expression over a full range. Controlling gene expression at the level of transcription allowed for a 40-fold range of expression to be investigated. However, the range in expression of the transcriptionally controlled system varied across cell lines. Expanding beyond this system, we have turned to controlling gene expression at the level of translation. Using translational control elements, we were able to varying gene expression over a 200 -- 300-fold range. Furthermore, the translational control system was shown to be consistent across six different cell lines and with every transgene that has been tested to date. To address the fact that cancer progression is a multi-faceted event, we developed a system that would allow observation of the effects resulting from the interactions of multiple genes. By using retroviral vectors equipped with fluorescent protein fusions, we successfully derived a system that has the capacity to interrogate up to three genes of interest within a single culture of cells. This single culture makes it logistically feasible to study such large combinations of gene dosage levels. This single culture is heterogeneous in expression for each of the transgenes introduced; and by utilizing flow cytometry, the precise dosage level of each transgene can be correlated to measureable phenotypes at the single-cell level. To demonstrate how the tools we have developed can be utilized to quantitatively assess gene-dosage profiles, we ectopically controlled the expression of various mutant forms of the oncogenic version of H-Ras (H-RasG12V) in both murine fibroblast and pre-B cells. We chose to study proliferation as a measurable phenotypic read-out. In NIH/3T3 fibroblasts we observed a maximum in proliferation at low levels of expression of H-RasG12V. A mutant version, H-RasG12V T35S, which is only able to signal down the MAPK pathway, exhibited maximal proliferation at intermediate expression levels. Other H-Ras mutants did not exhibit any proliferation optima when expressed by themselves. In contrast, when the mutants were investigated in pairwise fashion, some cooperation could be observed between particular mutant pairs. Finally, the effect of these H-Ras mutants on proliferation was investigated in a murine pre-B cell line. By adding a reference population of cells to a culture of cells expressing H-Ras mutant oncogenes over a range of expression levels, we were able to track the population dynamics between these two subsets of cells. A simple mathematical approach will be detailed to demonstrate how we can calculate the net proliferation rate as a function of H-Ras expression level by tracking the distribution of these two cell populations over time.
  • 2014From: CRCnetBASE
    edited by C. Murray Ardies.
    "The idea of producing a book on the prevention of chronic diseases through exercise and diet was intriguing for me when I was first approached with the idea. I had been teaching nutrition, exercise, and health science courses with a focus on cellular aspects of prevention for many years and had to develop all of my own materials because very few books were available. And of those that were, they had a decided clinical approach with very little discussion about the actual biochemistry or molecular mechanisms involved in prevention. When I broached the concept with several potential coauthors, the prevailing opinion was that books that covered biochemical and molecular aspects of disease etiology also were in very short supply. Thus this book was born: an attempt to collate the latest cellular- and molecularbased research on the etiology of chronic diseases with how these mechanisms of cause are modified by various aspects of diet and exercise. Essentially, we have tried to produce a text that translates molecular-based data on etiology and prevention into a clinical prescription for the prevention of chronic disease. The focus on diabetes, atherosclerosis, osteoporosis, cancer, and degenerative neurological disease is because they are the major causes of morbidity and mortality by chronic disease and also because there is sufficient molecular evidence for a strong dietary and activity (or rather, an insufficiency of both) component to their etiology. The inclusion of a separate chapter on "Inflammation" became necessary when it was clear that inflammatory signaling is a fundamental component of each of these diseases and that reducing inflammation is key to reducing risk for all of these diseases. At the time we started, obesity had not yet been declared a diseas"-- Provided by publisher.
  • 2012From: CRCnetBASE
    edited by Lonnie Michael Lowery, Jose Antonio.
    "There has been a long standing controversy in the field of sports nutrition regarding the role of protein and protein metabolism in muscle development and athletic performance. The understanding of protein nutrition has changed dramatically over the last decade and this book aims to clarify and modernize the topic. This book presents the efficacy, safety, and recommendations of protein intake among strength athletes. Including case studies, the text covers historical perspectives of protein use; safety of high protein diets; specific protein types and timing of intake; weight control using protein; protein synthesis and breakdown; and nitrogenous compounds/supplements"--Provided by publisher.
  • 2008From: Springer
    edited by Martino Bolognesi, Guido di Prisco, Cinzia Verde.
    Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathana (TM)s and Beaa (TM)s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
  • Limor Freifeld.
    Visual inputs are high-dimensional, dynamic, and may consist of significant levels of noise. Nevertheless, visual processing systems in many animals are capable of efficiently extracting information out of these signals to guide behavior. Flies, in particular, use visual information to guide behavior in challenging conditions such as during rapid flight maneuvers. In this dissertation we examine how early visual processing cells in the visual system of the Fruit Fly, Drosophila, achieve this feat. In particular, we focus on cells that provide inputs to motion detecting circuits and assess how these cells balance the goal of facilitating computational specializations with the goal of efficiently capturing all visual information. In these studies, we used two-photon calcium imaging in vivo to monitor the responses of specific cells in the fly visual system to visual stimuli. Using this system, we found that two first order interneurons providing inputs to pathways specialized for the detection of moving bright and dark edges nevertheless similarly encode information about both brightening and darkening. However, an in depth study of the functional properties of one of these interneurons revealed that it responds differently to bright and dark moving objects of different sizes in a manner that could facilitate the downstream specialization. Furthermore, via genetic and pharmacological manipulations it was found that GABAergic circuits providing lateral and feedback inputs to this cell enhance its responses to dark stimuli and thus enable it to relay critical information for the downstream pathway. These circuits were found to give rise to a center-surround antagonistic, anisotropic and spatiotemporally coupled RF structure in this cell. Interestingly, our studies uncovered deep similarities between the function of early visual processing cells in the fly and in vertebrate retinas. This suggests that different systems have converged on a similar set of solutions for addressing the challenge of efficiently using the resources available to the nervous system to process visual signals.
  • T.D. Barbara Nguyen-Vu.
    The focus of this thesis is to understand the contribution of multiple learning mechanisms to cerebellum-dependent motor learning. The studies that contribute to this thesis examine the role multiple learning mechanisms in the context of signaling in the intact circuit of awake-behaving animals. By using a well-parameterized learning paradigm, it is possible to distinguish and separate the contribution of specific learning mechanisms to different aspects of learning. This thesis demonstrates the sufficiency to two learning mechanisms long hypothesized to be important for cerebellum-dependent learning: 1) LTD at the parallel fiber to Purkinje cell synapse in the cortex (Marr 1969; Albus 1971; Ito 1972); and 2) the output of Purkinje cell simple spike activity (Miles & Lisberger 1981). Furthermore, the findings highlight the importance of understanding how learning mechanisms operate in vivo and interact with the on-going activity as well as previous activity in the circuit to determine different learning outcomes. The idea that the properties of a learning mechanism do not operate in isolation to produce learning but must be considered in the context of the intact and functional circuit is a common lesson that could apply to and should be tested in other learning systems of the brain.
  • 2008From: Springer
    M. Shakibaei, C. Csaki, and A. Mobasheri.
  • 2013From: Springer Protocols
    edited by Nadine Kabbani.
  • 2014From: ScienceDirect
    edited by Marco Diana, Gaetano Di Chiara and Pier Franco Spano.
    Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more. Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.The most acclaimed and accomplished series in neuroscienceThis volume looks at dopamine researchin the light of the newest scholarly discoveries and insights.
  • 2016From: ClinicalKey
    authors, Jay M. Weiss, Lyn D. Weiss, Julie K. Silver ; illustrator, Dennis J. Dowling.
    User-friendly and well organized, Easy EMG is designed to help residents learn the fundamental principles of electrodiagnostic testing (including nerve conduction studies and needle EMG). This one-of-a-kind resource offers expert guidance on performing and interpreting EMGs, as well as how to test the most common conditions encountered in daily practice. At-a-glance tables combine with clear illustrations and a pocket-sized format to make Easy EMG ideal for on-the-go reference!
  • 2017From: Oxford Medicine Online
    edited by Hein Heidbuchel, Mattias Duytschaever, Haran Burri.
  • 2013From: ScienceDirect
    2013From: ClinicalKey
    David C. Preston, Barbara E. Shapiro.
    Approach to Nerve Conduction Studies and Electromyography -- Anatomy and Neurophysiology -- Basic Nerve Conduction Studies -- Late Responses -- Blink Reflex -- Repetitive Nerve Stimulation -- Anomalous Innervations -- Artifacts and Technical Factors -- Basic Statistics for Electrodiagnostic Studies -- Routine Upper Extremity, Facial, and Phrenic Nerve Conduction Techniques -- Routine Lower Extremity Nerve Conduction Techniques -- Basic Overview of Electromyography -- Anatomy for Needle Electromyography -- Basic Electromyography: Analysis of Spontaneous Activity -- Basic Electromyography: Analysis of Motor Unit Action Potentials -- Clinical-Electrophysiologic Correlations: Overview and Common Patterns -- Median Neuropathy at the Wrist -- Proximal Median Neuropathy -- Ulnar Neuropathy at the Elbow -- Radial Neuropathy -- Peroneal Neuropathy -- Femoral Neuropathy -- Tarsal Tunnel Syndrome -- Facial and Trigeminal Neuropathy -- Polyneuropathy -- Amyotrophic Lateral Sclerosis and its Variants -- Atypical Motor Neuron Disorders -- Radiculopathy -- Brachial Plexopathy -- Proximal Neuropathies of the Shoulder and Arm -- Lumbosacral Plexopathy -- Sciatic Neuropathy -- Neuromuscular Junction Disorders -- Myopathy -- Myotonic Muscle Disorders and Periodic Paralysis Syndromes -- Approach to Electrodiagnostic Studies in the Intensive Care Unit -- Approach to Pediatric Electromyography -- Basics of Electricity and Electronics for Electrodiagnostic Studies -- Electrical Safety and Iatrogenic Complications of Electrodiagnostic Studies.
  • 2007From: ClinicalKey
    Bashar Katirji.
    The scope of the EMG examination -- Routine clinical electromyography -- Specialized electrodiagnostic studies -- Electrodiagnostic findings in neuromuscular disorders.
    Also available: Print – 2007
  • 2008From: Springer Protocols
    edited by Robert P. Vertes, Robert W. Stackman Jr.
    Field Potential Generation and Current Source Density Analysis / L. Stan Leung -- Current Source Density Analysis of Ongoing Neural Activity: Theory and Application / Yonghong Chen, Mukesh Dhamala, Anil Bollimunta, Charles E. Schroeder, Mingzhou Ding -- The Juxtacellular Recording-Labeling Technique / Didier Pinault -- Neural Recording Using Digital Telemetry / André A. Fenton, Kathryn J. Jeffery, James G. Donnett -- Large-Scale Neural Ensembles in Mice: Methods for Recording and Data Analysis / Hui Kuang, Joe Z. Tsien -- Behavioral Correlates of Neuronal Activity Recorded as Single-Units: Promises and Pitfalls as Illustrated by the Rodent Head Direction Cell Signal / Robert W. Stackman -- Event-Related Potentials of the Cerebral Cortex / Steven L. Bressler -- Multisite Spike-Field Coherence, Theta Rhythmicity, and Information Flow Within Papez's Circuit / Zimbul Albo, Gonzalo Viana Prisco, Robert P. Vertes -- Cognitively Relevant Recoding in Hippocampus: Beneficial Feedback of Ensemble Codes in a Closed Loop Paradigm / Robert E. Hampson, John D. Simeral, Theodore W. Berger, Dong Song, Rosa H. Chan, Vasilis Z. Marmarelis, Sam A. Deadwyler -- An Intact Septo-Hippocampal Preparation for Investigating the Mechanisms of Hippocampal Oscillation / Romain Goutagny, Jesse Jackson, Sylvain Williams -- Targeted Modulation of Neural Circuits: A New Treatment Strategy for Neuropsychiatric Disease / Helen S. Mayberg, Paul E. Holtzheimer.
  • sous la direction de Jean-Gaël Barbara & Pierre Corvol.
  • Anjali Joshi Shastri.
    The ubiquitous parasite Toxoplasma gondii has developed an exquisite arsenal of effectors to support its intracellular lifestyle and its persistence within its diverse hosts. In order to survive and resist clearance, this obligate intracellular parasite must contend with the host immune response. Different strains of the parasite vary dramatically in their interaction with the immune system, and studying these strain differences has furthered our understanding of the spectrum of host-pathogen interactions and led to the identification of parasite effectors. The work described here dissects the interactions between different strains of the parasite and host macrophages: innate immune cells that paradoxically both serve as a niche for parasite replication and defend the host against parasite infection. Chapter 1 introduces Toxoplasma, the immune response to infection, and discusses the role of known parasite effectors. Experiments described in Chapter 2 identify a novel secreted parasite factor, GRA25, which modulates cytokine secretion in macrophages and controls parasite virulence in mice. In Chapter 3, high throughput methods are used to characterize the transcriptional and phosphorylation landscape of macrophages infected with different Toxoplasma strains. These analyses demonstrate that a secreted polymorphic tyrosine kinase, ROP16, directs murine macrophage polarization towards an alternatively activated phenotype. They also reveal that Toxoplasma parasites activate the Type I interferon response, a response classically associated with cytosolic pathogens. Chapter 4 describes work demonstrating that Toxoplasma strain-specifically modulates the innate immune response via secretion of a parasite factor, MAF1, which recruits host mitochondria to the parasitophorous vacuole. Finally, Chapter 5 discusses the future directions and implications of this work in the broader context of host-pathogen interactions.
  • 1999-From: Wiley
    A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.
  • 2015From: Springer
    Roger G. Pertwee, editor.
    There is currently considerable interest in the development of medicines that would enhance endocannabinoid-induced ĺlautoprotectionĺl, for example through inhibition of endocannabinoid metabolizing enzymes or cellular uptake processes or that would oppose endocannabinoid-induced autoimpairment. This volume describes the physiology, pathophysiology and pharmacology of the endocannabinoid system and potential strategies for targeting this system in the clinic.
  • 2013From: Springer
    Mary E. Abood, Roger G. Sorensen, Nephi Stella, editors.
    Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • 2013From: ClinicalKey
    Bruce A. White, Susan P. Porterfield.
    Introduction to the endocrine system -- Endocrine function of the gastrointestinal tract -- Energy metabolism -- Calcium and phosphate homeostasis -- Hypothalamus-pituitary complex -- The thyroid gland -- The adrenal gland -- Life cycle of the male and female reproductive system -- The male reproductive system -- The female reproductive system -- Fertilization, pregnancy, and lactation.
  • 2013From: Springer
    Klaas R. Westerterp.
    Introduction, Energy Balance in Animals -- Energy Balance -- Limits in Energy Expenditure -- Energy Expenditure, Physical Activity, Body Weight and Body Composition -- Extremes in Energy Intake -- Body Weight -- Growth, Growth Efficiency and Ageing -- Modern Man in Line with Wild Mammals.
  • 2013From: ClinicalKey
    John R. Goldblum, Andrew L. Folpe, Sharon W. Weiss.
    Enzinger and Weiss's Soft Tissue Tumors is a medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
    Also available: Print – 2014
  • 2010From: Springer
    George A. Gerencser, editor.
    1. Chloride ATPase Pumps in Epithelia -- 2. Divalent Anion Transport in Crustacean and Molluscan Gastrointestinal Epithelia -- 3. Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes -- 4. Epithelial Calcium Transport in Crustaceans: Adaptation to Intrinsic and Extrinsic Stressors -- 5. The Cellular Basis of Extreme Alkali Secretion in Insects: A Tale of Two Tissues -- 6. H+, Na+, K+, and Amino Acid Transport in Caterpillar and Larval Mosquito Alimentary Canal -- 7. CFTR-Dependent Anion Transport in Airway Epithelia -- 8. Sulfate and Phosphate Transporters in Mammalian Renal and Gastrointestinal Systems -- 9. Role of H+-K+ ATPase, Na+-K+-2Cl− and Na+-Cl−-HCO3 − Transporters in Vertebrate Small Intestine -- 10. The H+- and H+, K+-ATPases of the Collecting Duct -- 11. Acid/Base Regulation in Renal Epithelia by H,K-ATPases -- 12. Sodium Transport Mechanisms in the Mammalian Nephron -- 13. Renal Acid-Base Regulation Via Ammonia Transport in Mammals -- 14. Hexose Transport Across Mammalian Epithelia -- 15. Amino Acid Transport by Epithelial Membranes -- 16. Molecular Ontology of Amino Acid Transport.
  • 2009From: Springer
    Ana Bracilović ; foreword by Donald J. Rose.
  • edited by Emma Ciafaloni, Patrick F. Chinnery, Robert C. Griggs.
    Status: Not Checked OutLane Catalog Record
    Structure and function of normal muscle / Robert C. Griggs -- Evaluation of the patient with myopathy / Robert C. Griggs, Emma Ciafaloni -- Genetic evaluation of the patient and family / Gerald Pfeffer, Patrick F. Chinnery -- The muscular dystrophies / Emma Ciafaloni, Robert C. Griggs -- Myofibrillar myopathies / Duygu Selcen -- Congenital myopathies / Francesco Muntoni, Caroline Sewry, Heinz Jungbluth -- Metabolic myopathies / Gráinne S. Gorman, Patrick F. Chinnery -- Mitochondrial myopathy / Gerald Pfeffer, Patrick F. Chinnery -- Muscle channelopathies / Araya Puwanant, Robert C. Griggs -- Inflammatory myopathies / Anthony A. Amato, Andrew Mammen -- Myopathies of systemic disease and toxic myopathies -- Muscle pain and fatigue / Michael R. Rose, Dr. Patrick Gordon -- Prevention and management of systemic complications of myopathies / Wendy M. King, Robert C. Griggs.
  • 2014From: Cambridge
    edited by Nick Harris, Fazal Ali.
  • 2003From: ScienceDirect
    edited by Charles M. Tipton.
    Ancient and early influences / Jack W. Berryman -- The neuromuscular system / Alan J. McComas -- The cardiovascular system / Loring B. Rowell -- The respiratory system / Jerome A. Dempsey and Brian J. Whipp -- The autonomic nervous system / Charles M. Tipton -- The oxygen transport system and maximal oxygen uptake / Jere H. Mitchell and Bengt Saltin -- The metabolic systems: aerobic metabolism and substrate utilization in exercising skeletal muscle / R. James Barnard and John O. Holloszy -- The metabolic systems: anaerobic metabolism (glycolytic and phosphagen) / George A. Brooks and L. Bruce Gladden -- The endocrine system: metabolic effects of the pancreatic, adrenal, thyroidal, and growth hormones / Michael C. Riddell ... [et al.] -- The temperature regulatory system / Elsworth R. Buskirk -- The renal system / Jacques R. Poortmans and Edward J. Zambraski -- The gastrointestinal system / Carl V. Gisolfi
  • 2010From: ClinicalKey
    [edited by] George Lawry [and others].
    Anatomy of joints, general considerations and principles of joint examination / George V. Lawry, Dennis Bewyer -- The shoulder / Murray J. Beuerlein , Michael D. McKee, Adel Fam -- The elbow / George V. Lawry, Terry Axelrod, Elizabeth Grigoriadis -- The wrist and hand / Arthur A.M. Bookman, Herbert P. von Schroeder, Adel Fam -- The hip / Hans J. Kreder -- The knee / Hans J. Kreder and Gillian Hawker -- The ankle and foot / Gregory W. Choy, David Stephen, Adel Fam -- The spine / George Lawry ... [et al.] -- The temporomandibular joint / Michael B. Goldberg ... [et al.] -- Principles of joint and periarticular aspirations and injections / Gillian Hawker, Elizabeth Grigoriadis, Adel G. Fam.
  • 2007From: Springer
    Gunter Klein, Peter Becker.
  • 2015From: Springer
    Erin Lawson, Mark S. Wallace, editors.
    Preface -- The Epidemiology and Prevalence of Fibromyalgia -- Fibromyalgia Diagnosis -- Etiology -- Prognosis -- Lifestyle Modification and Fibromyalgia -- Psychological Treatment for Fibromyalgia -- Medications -- Adjuvant Treatments for Fibromyalgia -- Utilizing Clinical Treatments with a Limited Evidence Base -- Treatment of Special Groups: Children, Pregnant, Elderly and Mentally-disabled -- Emerging Developments -- Nutrition.
  • 2011From: Springer
    Dawn A. Marcus, Atul Deodhar.
    Fibromyalgia definition and epidemiology -- Pathophysiology of fibromyalgia -- Assessment and diagnosis -- Headache -- Chronic fatigue syndrome -- Irritable bowel syndrome -- Sleep disturbance -- Depression and anxiety -- Obesity and metabolic syndrome -- Published recommendations -- Medication treatments -- Non-medication treatments -- Nutritional supplements -- Clinical handouts -- Fibromyalgia and pregnancy -- Fibromyalgia in seniors -- Gender and ethnic issues.
  • 2008From: Springer
    Jacqueline F. Webb, Richard R. Fay, Arthur N. Popper, editors.
    Introduction to fish bioacoustics / Richard R. Fay, Arthur N. Popper, and Jacqueline F. Webb -- Hearing and acoustic behavior: basic and applied considerations / Arthur N. Popper and Carl R. Schilt -- Structures and functions of the auditory nervous system of fishes / Richard R. Fay and Peggy L. Edds-Walton -- Evolution of peripheral mechanisms for the enhancement of sound reception / Christopher B. Braun and Terry Grande -- Bioacoustics and the lateral line system of fishes / Jacqueline F. Webb, John C. Montgomery, and Joachim Mogdans -- Orientation to auditory and lateral line stimuli / Olav Sand and Horst Bleckmann -- Multipole mechanisms for directional hearing in fish / Peter H. Rogers and David G. Zeddies -- Vocal-acoustic communication: from neurons to behavior / Andrew H. Bass and Friedrich Ladich -- Active and passive acoustics to locate and study fish / David A. Mann, Anthony D. Hawkins, and J. Michael Jech.
  • 2011From: Springer
    Andreas Wyttenbach, Vincent O'Connor, editors.
    Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
  • v. 1-8, 1974-91.From: Karger
  • 2012From: ScienceDirect
    Donna J. Cech and Suzanne 'Tink' Martin.
    Functional independence : a lifelong goal -- Theories affecting development -- Motor development -- Motor control and motor learning -- Evaluation of function, activity, and participation -- Skeletal system changes -- Muscle system changes -- Cardiovascular and pulmonary systems changes -- Nervous system changes -- Sensory system changes -- Vital functions -- Posture and balance -- Locomotion -- Prehension -- Health and fitness.
  • 2012From: Springer
    Nihat Özkaya, Margareta Nordin, David Goldsheyder, Dawn Leger.
    1. Introduction -- 2. Force Vector -- 3. Moment and Torque Vectors -- 4. Statics: Systems in Equilibrium -- 5. Applications of Statics to Biomechanics -- 6. Introduction to Dynamics -- 7. Linear Kinematics -- 8. Linear Kinetics -- 9. Angular Kinematics -- 10. Angular Kinetics -- 11. Impulse and Momentum -- 12. Introduction to Deformable Body Mechanics -- 13. Stress and Strain -- 14. Multiaxial Deformations and Stress Analyses -- 15. Mechanical Properties of Biological Tissues -- Appendex A. Plane Geometry -- Appendix B. Vector Algebra -- Appendix C. Calculus.
  • 2010From: Atypon
    Gerald E. Miller.
    Transport processes represents important life sustaining elements in all humans. These include mass transfer processes, including gas exchange in the lungs, transport across capillaries and alveoli, transport across the kidneys, and transport across cell membranes. These mass transfer processes affect how oxygen and carbon dioxide are exchanged in your bloodstream, how metabolic waste products are removed from your blood, how nutrients are transported to tissues, and how all cells function throughout the body. A discussion of kidney dialysis and gas exchange mechanisms is included. Another element in biomedical transport processes is that of momentum transport and fluid flow. This describes how blood is propelled from the heart and throughout the cardiovascular system, how blood elements affect the body, including gas exchange, infection control, clotting of blood, and blood flow resistance, which affects cardiac work. A discussion of the measurement of the blood resistance to flow (viscosity), blood flow, and pressure is also included. A third element in transport processes in the human body is that of heat transfer, including heat transfer inside the body towards the periphery as well as heat transfer from the body to the environment. A discussion of temperature measurements and body protection in extreme heat conditions is also included.
  • 2011From: Thieme Book
    edited by Joel Michael ; based on the work of Sabyasachi Sircar.
    The cell -- The cell membrane -- Genes and proteins -- Control systems and homeostasis -- Functional anatomy of the nervous system -- Resting membrane potential -- Membrane excitation and action potential -- Electrophysiology of ion channels -- Conduction of the action potential -- Sensory mechanisms -- Transmission of neuromuscular junctions and synapes -- The autonomic nervous system -- Functional anatomy of muscle -- Mechanism of muscle contraction -- Characteristics of muscle contraction -- Muscle elasticity -- Muscle mechanics -- Smooth muscle -- Cardiac muscle -- Body fluids and blood -- Red blood cells -- Hemoglobin -- Hemopoiesis -- Hermatinic factors -- Blood grouping and transfusion -- Blood platelets and hemostasis -- Hemostatic balance -- Granulocytes -- Agranulocytes and lymphoid organs -- Immunity, tolerance, and hypersensitivity -- Immune mechanisms -- Cardiac excitation and the electrocardiogram -- Cardiac cycle -- Cardiac output -- Circulatory pathway and hemodynamics -- Capillary exchange and lymphatic circulation -- Chemical and neural control of the cardiovascular system -- Blood pressure regulation -- Coronary circulation -- Cerebral circulation -- Pulmonary and pleural circulation -- Cutaneous, muscle, and splanchnic circulation -- Regulation of body temperature -- Functional anatomy of the respiratory system -- Mechanics of pulmonary ventilation -- Measurements of pulmonary ventilation -- Alveolar ventilation, perfusion, and gas exchange -- Transport of gases -- Neural control of respiratory rhythm -- Chemical control of pulmonary ventilation -- Respiration in unusual environments -- Pulmonary function tests and respiratory disorders -- Functional anatomy of the kidney -- Glomerular filtration and tubular reabsorption -- Renal handling of sodium -- Renal mechanisms determining urine osmolarity -- Body fluid and electrolyte balance -- Renal contribution to acid-base balance -- Renal handling of miscellaneous substances -- Hormones acting on the kidney -- Quantification of renal functions -- Whole body acid-base balance -- Renal syndromes -- Urinary bladder and micturition -- Nutritional needs of the body -- Functions of the mouth and esophagus -- Functions of the stomach -- Functions of the duodenum -- Functions of the small intestine -- Function of the colon -- Gastrointestinal hormones -- Gastrointestinal disorders -- Metabolic pathways -- Mechanism of hormonal action -- Hypothaoamic and pituitary hormones -- Thyroid hormones -- Hormones regulating calcium balance -- Hormones of the adrenal cortex -- Hormones of the adrenal medulla -- Pancreatic hormones and the regulation of blood glucose -- Testicular and ovarian hormones -- Puberty and gametogenesis -- Menstrual cycle -- Sperm transport and fertilization -- Sexual differentiation of the fetus -- Pregnancy -- Parturition and lactation -- Appendix A: Principles of physics in physiology -- Appendix B: Principles of chemistry in physiology -- Appendix C: Abbreviations used in text.
  • 2012From: Ovid
    [edited by] Cynthia Mattice, Rita Brooks, Teofilo Lee-Chiong.
    Section I. Overview of sleep medicine -- Section II. Anatomy and physiology -- Section III. Sleep disorders and disorders that affect sleep -- Section IV. Patient care and assessment -- Section V. Polysomnography -- Section VI. Interventions and therapeutics -- Section VII. Ancillary procedures -- Section VIII. Pediatrics -- Section IX. Sleep center management -- Section X. Appendix.
  • 2014From: Springer
    Eugene Trowers, Marc Tischler.
    This volume provides a practical hands on guide to gastrointestinal physiology. The book emphasizes an appreciation of basic physiological concepts and their application to novel clinical situations. It exposes the physician-in-training to fundamental principles that are useful in treating patients and lays the groundwork for more advanced study in the future. The authors present relevant cases which incorporate newer adult learning strategies in medical education. These cases provide a forum in which the student can apply acquired knowledge, skills and attitudes. Connections are made to reader's life, whether in the classroom, on the wards or out and about town. Designed for medical students who are studying gastrointestinal physiology for the first time, Gastrointestinal Physiology: A Clinical Approach provides a superb review for upper level medical students and house officers. Nursing and allied health professions students will also find this text to be a useful guide. GI fellows and attending physicians in need of a concise review of fundamental GI physiology principles will also benefit from reading this book.
  • 2014From: AccessMedicine
    Kim E. Barrett.
    Gastrointestinal Physiology explains the operation and performance of one of the body's most crucial systems. Using clear, compelling language, the book's presentation makes it easy to absorb the content and integrate it as you learn the physiology of other bodily systems. Written to help you understand essential concepts rather than merely memorize facts, this unique text examines many medically relevant facets of this important body system, including anatomy, pathophysiology, and therapeutics, in concert with physiological information.
  • 2013From: Springer
    K. Mohan Iyer, editor.
  • Thomas D. Glenn.
    The scope and complexity of the vertebrate nervous system requires the rapid transmission of neural impulses over long distances. The myelin sheath is an evolutionary adaptation that allows axons to rapidly propagate action potentials. Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) form myelin by wrapping their cell membranes around axons to form a multilayered membranous sheath that insulates and supports axons. Voltage gated sodium channels cluster at the unmyelinated gaps between myelin segments--the nodes of Ranvier. Depolarization of the axonal membrane at the nodes allows action potentials to propagate in a saltatory manner. Diseases of myelin, including multiple sclerosis in the CNS, and Charcot-Marie-Tooth disease in the PNS, underscore its clinical importance. In this dissertation, I focus on the mechanisms controlling the initiation and maturation of myelin in the PNS, as well as the role of Schwann cells in regulating sodium channel clustering at the nodes of Ranvier. Schwann cells arise from the neural crest in a series of developmental stages and depend upon axonal signals, such as Neuregulin 1 type III (Nrg1-III), for their survival and differentiation into myelinating Schwann cells. Nrg1-III signals control almost every aspect of Schwann cell development, but it has been proposed that other signaling pathways, such as those mediated by cyclic adenosine monophosphate (cAMP), may intersect with the Nrg1 pathway to affect a Schwann cell's response to Nrg1. In Chapter 2, I describe the identification of an orphan adhesion G protein-coupled receptor (GPCR), Gpr126, that was identified in a forward genetic screen in zebrafish. Gpr126 is essential for Schwann cells to initiate myelination, and gpr126 mutant zebrafish are devoid of PNS myelin. I show that Gpr126 is required cell-autonomously in Schwann cells to initiate myelination, and that elevating cAMP by drug treatment rescues myelination in gpr126 mutants in vivo. These results provide strong evidence that Gpr126 is the receptor that activates cAMP signaling to initiate myelination in Schwann cells in vivo. In Chapter 3, I demonstrate that although Gpr126 is essential for the initiation of myelination, it is no longer required for the maturation or maintenance of the myelin sheath. Notably, although Gpr126 signaling is required for the expression of the promyelinating transcription factor Krox20 during the initiation of myelination, Gpr126 signaling is dispensable for the maintenance of Krox20 expression. I further demonstrate that expression of activated protein kinase A (PKA) in Schwann cells is sufficient to rescue myelination in gpr126 mutants in vivo, but that over-expression of Nrg1-III in neurons is not. These results show that Gpr126 has a specific function during the initiation of myelination, and suggest that Gpr126 signaling functions in parallel to Nrg1 signaling. In chapter 4, I describe a novel role for Schwann cells in inhibiting the clustering of axonal sodium channels at the internodes, thereby confining sodium channel clustering to the nodes of Ranvier. Taken together, the findings described in this dissertation identify an orphan adhesion GPCR that regulates the initiation of myelination in Schwann cells, as well as define a novel role for Schwann cells in the regulation of sodium channel clustering.
  • 2016From: Springer
    Jason White, Gayle Smith, editors.
    This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.
    Also available: Print – 2016
  • 1868-From: Google Books
    Ranke, Johannes.
    Also available: Print – 1868.
  • 2016From: ClinicalKey
    John E. Hall.
  • 2014From: Springer
    Christopher C. Kaeding, James R. Borchers, editors.
    Injuries to the hamstring and quadriceps muscles can occur in both low- and high-impact sports and as such are among the more common injuries incurred by athletes. Reviewing the relevant physiology, epidemiology, mechanisms, clinical presentation and treatment of these conditions, Hamstring and Quadriceps Injuries in Athletes covers all sports-related injuries of the thigh musculature in one place. Topics covered include mid substance injuries, acute proximal tendon avulsions and harvesting of hamstrings, as well as strains, contusions and ruptures of the quadriceps, including the use of biologic enhancing agents in healing. Chapters on rehabilitation and injury prevention present techniques to maximize recovery and minimize long-term impairment, speeding up return to play. It will be an often-used and reliable guide for sports medicine practitioners, orthopedists, physical therapists, primary care physicians, team physicians and trainers who treat the injured athlete.
  • 2012From: Springer
    Victor R. Preedy, editor.
    pt. 1. Tools and techniques in anthropometry : general methods -- pt. 2. Tools and techniques in anthropometry : water, hydration and surface area -- pt. 3. Tools and techniques in anthropometry : muscle -- pt. 4. Tools and techniques in anthropometry : adipose tissue, other compartments and relationships -- pt. 5. Regions and anatomical areas of the body : head and face -- pt. 6. Regions and anatomical areas of the body : limbs, extremities and bones -- pt. 7. Regions and anatomical areas of the body : joints and digits -- pt. 8. Regions and anatomical areas of the body : abdominal and trunk regions -- pt. 9. Regions and anatomical areas of the body : sensory organs -- pt. 10. Regions and anatomical areas of the body : internal organs, other tissues and regions -- pt. 11. Anthropometry of pregnancy : prenatal and postnatal aspects -- pt. 12. Anthropometry of infants and children -- pt. 13. Anthropometry of puberty and adolescence in health and disease -- pt. 14. Anthropometry of middle-aged and aged in health and disease -- pt. 15. Anthropometry in genetic disease and polymorphisms -- pt. 16. Anthropometry in cancer -- pt. 17. Anthropometry in exercise and sport activities -- pt. 18. Anthropometry in metabolic disease and obesity -- pt. 19. Anthropometry in diabetes -- pt. 20. Anthropometry in cardiovascular disease -- pt. 21. Anthropometry in organ disease -- pt. 22. Anthropometry in special conditions and circumstances -- pt. 23. Anthropometry in ethnic groups and cultural and geographical diversity -- pt. 24. Anthropometry and nutrition : general aspects -- pt. 25. Anthropometry and nutrition : micro- and macro-nutrients -- pt. 26. Biomechanical and ergonomic aspects.
  • 2011From: Ovid
    Ramona Browder Lazenby.
    "This pathophysiology handbook is ideally suited for easy reference in the classroom or clinical environment. The book presents a summary of physiology concepts for each body system, followed by an overview of important pathophysiology concepts related to 'alterations' in that body system. These pathophysiology concepts provide the necessary foundation for understanding the disease or injury states that are presented next in the chapter"--Provided by publisher.
  • 2007From: Springer
    edited by Alexzander A.A. Asea and Antonio De Maio.
  • 2010From: Springer
    edited by Alexzander A.A. Asea and Bente K. Pedersen.
  • 2014From: Springer
    Erik R. Swenson, Peter Bärtsch, editors.
    Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude.--Excerpt from abstract.
  • 2010From: ClinicalKey
    Javad Parvizi ; Gregory K. Kim, associate editor.
    Here is a great reference source for use when preparing for board or re-certifying exams. High Yield Orthopaedics concisely conveys the most important information in the field with the aid of 600 illustrations--250 in full color. The consistent chapter format--covering every topic thoroughly from the pathophysiology and distribution to the symptoms and treatment--presents the material in a way that makes it easy to access and digest. Covers more than 200 topics with 460 illustrations--250 in full color--to provide you with a comprehensive yet focused resource. Emphasizes recognition of entities illustrated on the Board exams with two or more key clinical or pathological figures per writeup to give you the fullest understanding of the material. Presents topics selected based on the analysis of many years of examination experience so you get only the important information. Includes the most accurate information from experts who keep you current. Supplements topics with illustrations, tables, figures, radiographs, and even flow charts and equations to provide you with a visual understanding of the material. Features chapters organized alphabetically by disorder to help you find what you need fast. Conveys the information in a concise, yet structured manner for at-a-glance reference. Provides quick access to authoritative background with two or three critical references per writeup to extend your reading.
  • 2010From: Springer
    Mark P. Mattson, Edward J. Calabrese, editors.
  • 2016From: Springer
    Bernhard Kleine, Winfried G. Rossmanith.
    Introduction.-History of Hormones and Endocrinology -- I. Hormone biochemistry.-Hormones: Definitions.-Vertebrate Protein and Peptide Hormones.-Invertebrate protein and peptide hormones.-Hormones from Mevalonate: JH and Steroids.-Hormones Derived by Amino Acid Conversion.-Receptors.-II. Endocrine physiology.-Synthesis, Release, and Action.-Endocrine active organs.-Regulatory Patterns.-Endocrine Rock 'n Roll: Rhythms and Secretion -- Evolution of the Endocrine System.-III. Hormones and medicine.-Diseases of the Endocrine System.-Boosting Performance-Legally or Not.-IV. Appendix.-A. Appendix.-B. References.-C. Index.
  • Katerina Blazek.
    Obesity, a condition characterized by excess adipose tissue, is becoming an important public health problem. Not only has the prevalence rate in adults risen steadily since the 1980's, obesity is a strong risk factor for the development of knee osteoarthritis (OA) and general mobility disability. There are currently no disease-modifying treatments for OA, so it is important to develop preventive strategies. However, we must first understand the mechanism of increased risk in the obese population. Knee cartilage and other joint structures respond both to mechanical loads during activities of daily living and to the biological environment within the joint, so the pathway to OA in the obese population therefore likely involves changes in both. The primary goal of this dissertation was to test the hypothesis that aging and obesity are linked to changes in gait mechanics and changes in the relationship between cartilage morphology and joint loads, and that these changes are consistent with increased knee OA risk. We also analyzed whether these changes are also observed in individuals with early asymptomatic knee joint degeneration. Finally, we tested the hypothesis that stair climbing requires adaptive changes that reflect a reduction in muscle strength in the aging obese population and indicate increased mobility disability risk. The results indicate that in obese, but not normal-weight individuals, age was associated with an increased adduction moment, which reflects increased loads on the medial compartment of the knee. Furthermore, the positive relationship between cartilage thickness and ambulatory load in young subjects was significantly weaker in middle-aged obese individuals. The increased OA risk in older obese individuals is therefore likely due to both an increase in ambulatory loads and to a change in the relationship between those ambulatory loads and cartilage properties due to the elevated pro-inflammatory cytokine levels characteristic of obesity. During stair climbing, middle-aged obese individuals also had lower peak knee flexion moments, indicative of quadriceps weakness due to aging and relative to their weight. Finally, the gait and stair climbing mechanics of individuals with early OA were not different from their age- and BMI-matched healthy counterparts, indicating that the gait alterations seen in healthy middle-aged obese individuals are the same as those in obese individuals who have already developed the disease, and are likely risk factors or early functional markers of OA.
  • 2009From: ClinicalKey
    edited by R.E. Mansel, D.J.T. Webster, H.M. Sweetland ; with the collaboration of L.E. Hughes, K. Gower-Thomas, D.G.R. Evans ; with a foreword by H.S. Cody III.
    Foreword -- Preface -- Acknowledgementsi -- Dedication -- Chapter 1 Problems of concept and nomenclature of benign disorders of the breast -- Key points and new developments -- The source of the problem -- History -- The present and the future -- References -- Chapter 2 History of benign breast disease -- Introduction -- Sir Astley Paston Cooper, Bt. FRS DCL GCH. 1768-1841 -- Alfred Velpeau. 1785-1867 -- John Birkett FRCS Fellow of the Linnean Society. 1815-1904 -- George Lenthal Cheatle. 1865-1951 -- Joseph Colt Bloodgood. 1867-1935 -- Charles F. Geschickter. 1901-? -- An analysis of the contributions of these six men -- References -- Chapter 3 Breast anatomy and physiology -- Key points and new developments -- Development -- Changes at puberty -- Adult anatomy -- Microscopic anatomy -- Biochemical control of breast epithelium -- Cyclical changes in breast epithelium -- Changes during pregnancy and lactation -- Postmenopausal involution -- References -- Chapter 4 Aberrations of normal development and involution (ANDI): a concept -- of benign breast disorders based on pathogenesis -- Key points and new developments -- Introduction -- Recognition of the normality of much benign breast disease -- Problems with the conventional view of benign breast disease -- The physiological processes underlying the ANDI concept -- A framework based on pathogenesis -- Reasons for including various benign breast disorders as part of ANDI -- An extension of the concept of ANDI to include most benign breast disorders? -- Implications for the management of benign breast disorders -- Aberration to disease? -- Recent developments having a bearing on the ANDI concept -- References -- Chapter 5 The approach to diagnosis and assessment of breast lumps -- Key points and new developments -- Part 1: The differential diagnosis and clinical assessment of breast lumps -- Clinical assessment of a breast lump -- Features of individual lesions -- Follow-up after assessment and/or benign breast biopsy -- Management of recurrent lumps following biopsy -- Breast masses related to different life periods -- Part 2: Triple assessment and organization of the breast clinic -- Fine needle aspiration cytology -- Ultrasound in triple assessment -- Wide-bore needle biopsy -- Mammotome or vacuum-assisted biopsy -- Organization of clinics -- Medico-legal issues -- References -- Chapter 6 Imaging of the breast -- Key points and new developments -- Introduction -- Breast density -- Mammography -- Breast ultrasound -- Breast magnetic resonance imaging -- Biopsy techniques -- Breast localization techniques -- References -- Chapter 7 Fibroadenoma and related tumours -- Key points and new developments -- Terminology -- Fibroadenoma simplex -- Cancer and fibroadenoma -- Multiple fibroadenomas -- Giant fibroadenoma -- Phyllodes tumour and phyllodes sarcoma (cystosarcoma phyllodes) -- Pseudoangiomatous hyperplasia -- References -- Chapter 8 Breast pain and nodularity -- Key points and new developments -- Introduction -- Historical note -- Frequency of breast pain -- Mastalgia in breast cancer -- Classification -- Aetiology of mastalgia and nodularity -- Management of patients with mastalgia -- Natural history of mastalgia -- Plan of management for patients with mastalgia -- Mastalgia in the postmenopausal patient -- Patients with refractory mastalgia -- The relationship of cyclical mastalgia to premenstrual stress -- Conclusion -- References -- Chapter 9 Sclerosing adenosis, radial scar and complex sclerosing lesions -- Key points and new developments -- Introduction -- Sclerosing adenosis -- Radial scar and complex sclerosing lesions -- References -- Chapter 10 Cysts of the breast -- Key points and new developments -- Introduction -- Pathology -- Incidence -- Pathogenesis and cyst types -- Aetiology -- Clinical features -- Age -- Natural history -- Investigation -- Differential diagnosis -- management -- Galactocele -- Papillary tumours associated with macrocysts -- References -- Chapter 11 The duct ectasia/periductal mastitis complex -- Key points and new developments -- Introduction -- Historical survey -- Pathology and pathogenesis of duct ectasia/periductal mastitis -- The development of the duct ectasia/periductal mastitis complex -- The clinical spectrum of duct ectasia/periductal mastitis -- Breast masses associated with periductal mastitis -- Frequency of duct ectasia/periductal mastitis -- Radiology -- Management -- The consequences and results of operations for duct actasia -- Recurrent infection after surgery for periductal mastitis -- References -- Chapter 12 Disorders of the nipple and areola -- Key points and new developments -- Introduction -- Nipple inversion and retraction -- Cracked nipples -- Nipple crusting -- Erosive adenomatosis -- Syringomatous adenoma -- Nodular mucinosis -- Simple fibroepithelial polyp -- Eczema -- Leiomyoma -- Traumatic lesions -- Nipple pain -- Nipple disease and HIV infection -- Montgomery's glands -- Sebaceous cyst of the nipple -- Viral infections -- Hidradenitis suppurativa of the areola -- References -- Chapter 13 Nipple discharge -- Key points and new developments -- Introduction -- Definition -- Incidence -- Character and significance of discharge -- Pathology underlying nipple discharge -- Assessment -- Management -- References -- Chapter 14 Infections of the breast -- Key points and new developments -- Introduction -- Lactational breast infection -- Subclinical mastitis -- Nonlactational breast abscess -- Infections in immunocompromised patients -- Iatrogenic abscess -- Specific infections of the breast -- Infections of associated structures -- References -- Chapter 15 Congenital and growth disorders -- Key points and new developments -- Introduction -- Developmental anomalies -- Premature breast development -- Hypertrophic abnormalities of the breast -- Excessive postlactational involution -- Genetic abnormalities involving the breast -- Surgical treatment -- References -- Chapter 16 The male breast -- Key points and new developments -- Development of the male breast -- Gynaecomastia -- Other male breast disease -- References -- Chapter 17 Miscellaneous conditions -- Introduction -- Trauma -- Fat necrosis -- Paraffinoma and silicone reactions -- Lipoma -- Hamartoma (adenolipoma) -- Oedema of the breast -- The post-irradiated breast -- Fibrous disease of the breast -- Fibromatosis (desmoid tumour) -- Nodular fasciitis -- Diabetic mastopathy -- Idiopathic granulomatous mastitis (non-specific granulomatous disease) -- Sarcoid -- Amyloid -- Blood vessels -- Atherosclerosis and aneurysm -- Mondor's disease -- Infarction -- Skin-related conditions -- Hidradenitis suppurativa of the breast -- Tumours of nerve origin -- Granular cell tumour (myoblastoma) -- Artefactual disease of the breast -- Foreign bodies -- Mammalithiasis -- Phantom breast syndrome -- Mammary mucocele-like lesion -- Breast tumour of pregnancy (lactating adenoma) -- Collagenous spherulosis of the breast -- Gynaecomastia-like lesions in women -- References -- Chapter 18 Operations -- Introduction -- Tissue diagnosis in the clinic -- Removal of giant fibroadenoma and phyllodes tumour -- Microdochectomy -- Excision of mammary duct fistula -- Major duct excision (Adair/Urban/Hadfield) -- Drainage of a lactational breast abscess -- Subcutaneous mastectomy in male patients -- Subcutaneous mastectomy or skin sparing mastectomy in women -- Operations for inverted nipples -- References -- Chapter 19 Psychological aspects of benign breast disease -- Key points and new developments -- Introduction -- Psychological problems resulting from presenting with breast problems -- Psychological abnormality as a cause of benign breast disease -- References -- Chapter 20 Risk assessment and management -- Summary -- Breast cancer: the disease -- The breast cancer genes -- Conclusion -- References -- Index.
  • 2012From: ScienceDirect
    edited by Noël Cameron and Barry Bogin.
    The human growth curve, canalization and catch-up growth / Noël Cameron -- Growth in infancy and childhood: a pediatric approach / Horacio Lejarraga -- Adolescent growth / Roland Hauspie and Mathieu Roelants -- Puberty / Peter T. Ellison and Meredith W. Reiches -- Endocrine control of growth / Ron G. Rosenfeld -- Nutrition and growth / Nicholas G. Norgan, Barry bogin and Noël Cameron -- Genomics, epigenetics and growth / Geert R. Mortier and Wim Vanden Berghe -- The genetic epidemiology of growth and development / Bradford Towne, Ellen W. Demerath and Stefan A. Czerwinski -- Social and economic effects on growth / Richard H. Steckel -- Environmental effects on growth / Lawrence M. Schell, Kristen L. Knutson and Stephen Bailey -- The evolution of human growt / Barry Bogin -- Early environments, developmental plasticity and chronic degenerative disease / Christopher W. Kuzawa -- Leg length, body proportion, health and beauty / Barry Bogin -- Physical activity as a factor in growth and maturation / Robert M. Malina -- Comparative and evolutionary perspectives on human brain growth / William R. Leonard, J. Josh Snodgrass and Marcia L. Robertson -- Saltation and stasis / Michelle Lampl -- Lectures on human growth / Peter C. Hindmarsh -- Body composition during growth and development / Babette S. Zemel -- The measurement of human growth / Noël Cameron -- Assessment of maturation / Noël Cameron -- Growth references and standards / T.J. Cole.
  • 2008From: Springer
    edited by Bodo Rosenhahn, Reinhard Klette, and Dimitris Metaxas.
    1. Understanding human motion: a historic review / Reinhard Klette and Garry Tee -- pt. I. 2D tracking: 2. The role of manifold learning in human motion analysis / Ahmed Elgammal and Chan-Su Lee ; 3. Recognition of action as a Bayesian parameter estimation problem over time / Volker Krüger ; 4. The William Harvey code: mathematical analysis of optical flow computation for cardiac motion / Yusuke Kameda and Atsushi Imiya ; 5. Detection and tracking of humans in single view sequences using 2D articulated model / Filip Korč and Václav Hlaváč -- pt. II. Learning: 6. Combining discrete and continuous 3D trackers / Gabriel Tsechpenakis, Dimitris Metaxas, and Carol Neidle ; 7. Graphical models for human motion modelling / Kooksang Moon and Vladimir Pavlović ; 8. 3D human motion analysis in monocular video: techniques and challenges / Christian Sminchisescu ; 9. Spatially and temporally segmenting movement to recognize actions / Richard Green ; 10. Topologically constrained idometric embedding / Guy Rosman, Alexander M. Bronstein, Michael M. Bronstein, and Ron Kimmel -- pt. III. 2D-3D tracking: 11. Contours, optic flow, and prior knowledge: cues for capturing 3D human motion in videos / Thomas Brox, Bodo Rosenhahn, and Daniel Cremers ; 12. Tracking clothed people / Bodo Rosenhahn, Uwe G. Kersting, Katie Powell, T. Brox, and Hans-Peter Seidel ; 13. An introduction to interacting simulated annealing / Jürgen Gall, Bodo Rosenhahn, and Hans-Peter Seidel ; 14. Motion capture for interaction environments / Daniel Grest and Reinhard Koch ; 15. Markerless motion capture for biomechanical applications / Lars Mündermann, Stefano Corazza, and Thomas P. Andriacchi -- pt. IV. Biomechanics and applications: 16. Qualitative and quantitative aspects of movement: the discrepancy between clinical gait analysis and activities of daily life / Dieter Rosenbaum and Mirko Brandes ; 17. Optimization of human motion exemplified with handbiking by means of motion analysis and musculoskeletal models / Harald Böhm and Christian Krämer ; 18. Imitation learning and transferring of human movement and hand grasping to adapt to environment changes / Stephan Al-Zubi and Gerald Sommer ; 19. Accurate and model-free pose estimation of crash test dummies / Stefan K. Gehrig, Hernán Badino, and Jürgen Gall -- pt. V. Modelling and animation: 20. A relational approach to content-based analysis of motion capture data / Meinard Müller and Tido Röder ; 21. The representation of rigid body motions in the conformal model of geometric algebra / Leo Dorst ; 22. Video-based capturing and rendering of people / Christian Theobalt, Marcus Magnor, and Hans-Peter Seidel ; 23. Interacting deformable objects / Matthias Teschner, Bruno Heidelberger, and Matthias Müller-Fischer ; 24. From performance theory to character animation tools / Michael Neff and Eugene Fiume.
  • 2006From: Springer
    edited by Robert C. Roach, Peter D. Wagner, Peter H. Hackett.
    Hypoxia honoree. -- A tribute to John Burnard West / James S. Milledge. Adventures in High-altitude physiology / John B. West -- Exercise-induced hypoxemia (EIH): causes and consequences. -- Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation / Susan R. Hopkins. Intrapulmonary shunt during normoxic and hypoxic exercise in healthy humans / Andrew T. Lovering, Michael K. Stickland, Marlowe W. Eldridge. Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue / Lee M. Romer ... [et al.] -- Causes and effects of sleep-disordered breathing. -- Mechanisms of sleep apnea at altitude / William Whitelaw. Control of cerebral blood flow during sleep and the effects of hypoxia / Douglas R. Corfield and Guy E. Meadows. Neural consequences of sleep disordered breathing: the role of intermittent hypoxia / Mary J. Morrell and Gillian Twigg -- Genetic, genomics, and adaptation to high altitude. -- Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping / Mark D. Shriver ... [et al.] An evolutionary model for identifying genetic adaptation to high altitude / Lorna G. Moore ... [et al.] Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration / Christian Grimm ... [et al.] -- Blocking stress pathways with cell-permeable membranes. -- Blocking stress signaling pathways with cell permeable peptides / Christophe Bonny. JNK pathway as therapeutic target to prevent degeneration in the central nervous system / Mariaelena Repici and Tiziana Borsello. Salvage of ischemic myocardium: a focus on JNK / Hervé Duplain -- The impact of immobilization and hypoxia on skeletal muscle. -- Mitochondrial reactive oxygen species are required for hypoxic hif[alpha] stabilization / M. Celeste Simon. Hypoxia-induced gene activity in disused oxidative muscle / Christoph Däpp ... [et al.] -- Hypoxic vasoregulation: interactions of red cells, endothelium, and smooth muscle. -- Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation / Mark T. Gladwin. Expression of the heterotrimeric G protein gi and ATP release are impaired in erythrocytes of humans with diabetes mellitus / Randy Sprague ... [et al.] Red blood cells and hemoglobin in hypoxic pulmonary vasoconstriction / Steven Deem -- Hypoxia: state of the art. -- Dose-response of altitude training: how much altitude is enough? / Benjamin D. Levine, James Stray-Gundersen. The eye at altitude / Daniel S. Morris ... [et al.] Lake Louise consensus methods for measuring the hypoxic ventilatory response / Frank L. Powell -- Future directions in hypoxia research. -- Pulmonary hypertension in high-altitude dwellers: novel mechanisms, unsuspected predisposing factors / Urs Scherrer ... [et al.] Gene huntin in hypoxia and exercise / Kenneth B. Storey.
    Also available: Print – 2006
  • 2007From: Springer
    edited by Robert C. Roach, Peter D. Wagner, Peter H. Hackett.
    Risk of cardiovascular events during mountain activities / Martin Burtshcer -- Biventricular function at high altitude: implications for regulation of stroke volume in chronic hypoxia / Simon R. Gibbs -- Control of coronary blood flow during hypoxemia / Johnathan D. Tune -- Metabolic consequences of intermittent hypoxia / Christopher P. O'Donnell -- Intermittent hypoxia and cognitive function: implications from chronic animal models / Barry W. Row -- Vascular consequences of intermittent hypoxia / Barbara J. Morgan -- Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation / Masaomi Nangaku ... [et al.] -- Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling / Eva Nozik-Grayck and Kurt R. Stenmark -- Hypoxia and placental remodeling / Judith E. Cartwright ... [et. al.] -- Epithelial sodium channels in the adult lung - important modulators of pulmonary health and disease / Ian C. Davis and Sadis Matalon -- Lung interstitial pressure and structure in acute hypoxia / Giuseppe Miserocchi -- Hypoxic inhibition of alveolar fluid reabsorption / Laura A. Dada and Jacob I. Sznajder -- Regulation and role of neuroglobin in cytoglobin under hypoxia / Thorsten Burmester, Frank Gerlach, and Thomas Hankeln -- Molecular insights into the functional role of myoglobin / Daniel J. Garry and Pradeep P.A. Mammen -- Genetic mechanisms underlying regulation of hemoglobin mass / neeraj Agarwal, Victor R. Gordeuk, and Josef T. Prchal -- Control of the respiratory patterns in insects / Timothy J. Bradley -- Effects of insect body size on tracheal structure and function / Scott D. Kirkton -- The role of HIF-1 in hypoxic response in the skeletal muscle / Steven Mason and Randall S. Johnson -- Gene expression in working skeletal muscle / Hans Hoppeler, Stephan Klossner, and Martin Fluck -- The limits of human endurance: what is the greatest endurance performance of all time? Which factors regulate performance at extreme altitude / Timothy David Noakes -- Jim Milledge: hypoxia honoree 2007 / Annabel Nikol -- Exploring mountain medicine and physiology / James S. Milledge -- Carlos Monge Cassinelli: a portrait / Fabiola Leon-Velarde S. and Jean-Paul Richalet.
    Also available: Print – 2007
  • 2015From: Springer Protocols
    edited by Albert C. Shaw.
    Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.
  • Laura Marie Prolo.
    Lysosomal storage disorders are inherited diseases caused by defects in lysosomal function. The free sialic acid storage disorders are allelic diseases that are caused by mutations in the gene encoding a lysosomal membrane protein called sialin. This protein transports the acidic sugar, sialic acid, out of lysosomes after it has been cleaved off of glycoconjugates undergoing degradation. Accumulation of sialic acid in lysosomes defines these disorders, but it is not known how this biochemical defect leads to the clinical manifestations. Significant advances in our understanding of the pathophysiology and in treatment have been hindered by the lack of an animal model. In the studies described here I characterize a sialin deficient mouse and provide evidence that it faithfully models important aspects of the human disease. A major finding in the human disease and in the sialin-/- mouse is impaired central nervous system (CNS) myelination. To investigate potential mechanisms underlying CNS hypomyelination, I studied oligodendrocyte development and myelination in optic nerves of the sialin deficient mice. I found reduced numbers of myelinated axons, but the myelin that was present appeared grossly normal. Migration and density of oligodendrocyte precursor cells (OPCs) were normal; however, I observed a marked decrease in the number of postmitotic oligodendrocytes and an associated increase in the number of apoptotic cells during the later stages of myelinogenesis. These findings suggest that a defect in maturation of cells in the oligodendrocyte lineage leads to increased apoptosis and underlies the myelination defect associated with sialin loss. I hypothesized that improper metabolism of sialic acid containing proteins and lipids (gangliosides) may explain some aspects of the disease phenotype. I found a delay in the developmentally regulated reduction in expression of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a glycoconjugate that inhibits myelin formation, which provides a potential molecular mechanism for the impaired myelination and reduction in oligodendrocyte number. Further, I found elevated levels of gangliosides in the sialin-/- mouse brain with the most noticeable change in the level of ganglioside GM2. To further studies of the myelination defect, I have established a cerebellar slice-OPC coculture myelination assay. This ex vivo system will allow investigators to test specific hypotheses about the cellular and molecular basis of the myelination defect and can eventually be used to assess potential treatments.
  • 2009From: IngentaConnect
    Galina Kichigina.
    Part I. The German laboratory and 'scientific medicine' in the late 1850s and early 1860s: a Russian view -- 1. The Old-new tradition -- 2. Physiologist-physicists: foundation of the discipline -- 3. A Viennese prelude: Sechenov's research at Ludwig's laboratory -- 4. Berlin wins over Paris and Vienna: Botkin's view on European clinics -- 5. 'Alt Heidelberg, du feine ...' -- Part II. The St Petersburg Medico-Surgical Academy and experimental science -- 6. Military medical education: the aftermath of the Crimean War -- 7. The Winds of change: reformation of the Medico-Surgical Academy -- 8. The 'Medico-Chemical Academy': Zinin's laboratory -- 9. Synthesis and symphonies: Borodin's laboratory -- 10. 'Scientific medicine': Botkin's teaching clinic and laboratory -- 11. The New discipline of Russian physiology: Sechenov's labortory 12. A Few steps further: the operation of the physiological laboratory under Cyon -- Part III. From physics and chemistry of the body to physical chemistry: Sechenov's research on blood gases and salt solutions -- 13. Russian universities in the sea of change, 1870-1886 -- 14. Sechenov at Novorossiisk University: new laboratory, new challenges -- 15. A Simple model: transition from blood-gas research to studies on salt solutions -- 16. Sechenov at St Petersburg: 'Galvanic studies'-- a final proof -- 17. The Context to Sechenov's study of solution: the Mendeleev-Ostwald debate on the theory of solutions -- The Universal law: expectations and disappointments.
    Also available: Print – 2009
  • 2009From: Springer
    Espinos, Carmen; Felipo, Vicente; Palau, Francesc.
    Pathology and diagnosis of muscular dystrophies / Carmen Navarro, Susana Teijeira, Beatriz San Millan.-- Standards of care for Duehenne muscular dystrophy: brief treat-NMD recommendations / Thomas Sejerson, Kate Bushby on behalf of the TREAT-EU Network of Excellence.-- Genetics and pahtogenesis of distal muscular dystrophies / Bjarne Udd.-- Phenotype variations in early onset Pompe disease: Diagnosis and treatment results with Myozyme [RTM] / Samuel Ignacio Pascual Pascual.-- Diseases of the human mitochondrial oxidative phosphorylation system / Julio Montoya, Ester Lopez-Gallardo, Maria Dolores Herrero-Martin, Inigo Martinze-Romero, Aurora Gomez-Duran, Daivd Pacheu, Magdalena Garreras, Carme Diez-Sanchez, Manuel J. Lopez-Perez, Eduardo Ruiz-Pesini.-- Mitochondrial diseases: a cross-talk between mitrochondrial and nuclear genomes / Antonella Spinazzola, Massimo Zeviani.-- Mitochondrial disorders due to nuclear OXPHOS gene defects / Cristina Ugalde, Maria Moran, Alberto Blazquez, Joaquin Arenas, Miguel A. Martin.-- Coenzyme Q10 deficiencies in neuromuscular diseases / Rafael Artuch, Leonardo Salviati, Sandra Jackson, Michio Hirano, Placido Navas.-- The role of mitochondrial network dynamics in the pathogenesis of Charcot-Marie-Tooth disease / Francese Palau, Anna Estela, David Pla-Martin, Maribel Sanchez-Piris.-- Pathogenesis and treatment of mitochondrial disorders / Salvatore DiMauro, Michio Hirano.-- Biology of peripheral inherited neuropathies: Schwann cell axonal interactions / Michael E. Shy.-- Phenotype and clinical evolution of Charcot-Marie-Tooth disease type 1A duplication / Jose Berciano, Antonio Garcia, Elena Gallardo, Cesar Ramon, Onofre Combarros.-- Genotypes & sensory pheotypes in 2 new X-linked neuropathies (CMTX3 and dSMAX) and dominant CMT/HMN overlap syndromes.-- Natural history and treatment of peripheral inherited neuropathies / Davide Pareyson, Chiara Marchesi.-- Spinal muscular atrophy during human development: where are the early pathogenic findings / Eduardo Tizzano.-- Spinal muscular atrophy / Jeremie Vitte, Ruben Attali, Nasim Warwar, Irena Gurt, Judith Melki.-- Friedreich ataxia: an update on animal models, frataxin function and therapies / Pilar Gonzalez-Cabo, Jose Vicente Llorens, Francesc Palau, Maria Dolores Molto.-- Genetics and pathogenesis of inherited ataxias and spastic paraplegias / Carmen Espinos, Francesc Palau.
    Also available: Print – 2009
  • Liang Liang.
    Inhibition occurs throughout the nervous system and impacts diverse neuronal processes. In this dissertation, I focus on an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from the classical feed-forward or feedback inhibition. The Drosophila excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel output to the lateral horn, a higher-order brain center implicated in regulating innate olfactory behavior. By incorporating in vivo two-photon calcium imaging, advanced fly genetics and optogenetic methods to manipulate and record neuronal activity, we find that iPNs selectively suppress food-related odorant responses but spare signals from pheromone channel stimulation when using specific lateral horn neurons as an olfactory readout. Co-applying food odorant does not affect pheromone signal transmission, suggesting that the differential effects likely result from connection specificity of iPNs, rather than a generalized inhibitory tone. Calcium responses in the ePN axon terminals show no detectable suppression by iPNs, arguing against presynaptic inhibition as a primary mechanism. The parallel inhibition motif may provide specificity in inhibition to funnel specific olfactory information, such as food and pheromone, into distinct downstream circuits.
  • 2013From: Springer
    Pascal Belin, Salvatore Campanella, Thomas Ethofer, editors.
    This book follows a successful symposium organized in June 2009 at the Human Brain Mapping conference. The topic is at the crossroads of two domains of increasing importance and appeal in the neuroimaging/neuroscience community: multi-modal integration, and social neuroscience. Most of our social interactions involve combining information from both the face and voice of other persons: speech information, but also crucial nonverbal information on the person's identity and affective state. The cerebral bases of the multimodal integration of speech have been intensively investigated; by contrast only few studies have focused on nonverbal aspects of face-voice integration. This work highlights recent advances in investigations of the behavioral and cerebral bases of face-voice multimodal integration in the context of person perception, focusing on the integration of affective and identity information. Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.
  • Alan Edward Rorie.
    The work presented in this dissertation primarily focuses on decision-related activity in the lateral intraparietal area (LIP) and, secondarily, the dorsolateral prefrontal cortex (DLPFC). In Chapter 1 we review the previous independent investigations indicating that these areas are separately modulated by sensory information, value information and choice appropriate to represent decisions. We argue that when both sensory and value information must be simultaneously integrated to make choices, it is unknown, if, how and when these areas integrate these factors. We present a behavioral paradigm in which animal subjects must combine sensory and value information, on a trial-to-trial basis, to make optimal choices. This paradigm is based on a well-known motion discrimination task; however, in our task the magnitude of the reward associated with each option varies from trial to trial. On some trials both options are worth equally large or small rewards. On other trials one option's reward is greater than that of the other. In Chapter 2, we demonstrate that in the unequal reward conditions subjects' choices are consistently biased towards the greater magnitude option. Additionally, we will show that this bias is independent of the motion stimulus strength and its magnitude is nearly optimal. In Chapter 3, we observe that single neurons in cortical area LIP consistently, simultaneously and dynamically represent both sensory and value information. We will argue that this representation supports an integrator model of decision making, in which sensory information is accumulated until the decision is resolved by a threshold crossing. Our results support an interpretation of this model in which value information adjusts the likelihood of a threshold crossing by iv raising or lowering the accumulator's initial state. In Chapter 4, we present a preliminary comparison between LIP and DLPFC activity, under identical conditions, suggesting they play fundamentally different roles in decision making. In Chapter 5, we discuss future lines of research.
  • Status: Not Checked OutLane Catalog Record
  • Rodrigo Alvarez-Icaza Rivera.
    In this dissertation, I revisit Kawato's proposal, that the cerebellum predictively modulates descending motor commands, to achieve smooth and coordinated motion, by acquiring an inverse model of the biomechanical plant, and extend it by describing a novel and precise mapping between a cerebellar multizonal microcomplex and a joint's inverse model. This mapping renders two novel predictions: First, inferior olive's oscillations mirror the biomechanical joint's oscillations. Second, deep cerebellar neurons implement a gain factor, set by Purkinje cell inhibition, on inferior olive's signals to mirror the spinal cord's gain. I use biophysical modeling to show that oscillations within the inferior olive match the range of natural frequencies and damping ratios of biophysical joints, and that deep cerebellar neurons enable a multiplicative interaction between the Purkinje and the olivary pathways. Furthermore, I determine the effects of current injection into the inferior olive and the deep cerebellar nuclei and use these results within a control theory model to predict that experimentally disturbing the inferior olive will introduce motor output ringing, while disturbing the deep nuclei will also scale motor output. In both cases, manipulating the inverse model implemented by microzonal microcomplex will unmask the joint's natural dynamics as observed by motor ringing at the joint's natural frequency.
  • 2012From: Springer Protocols
    edited by Klaus Ballanyi.
    Autonomic nervous system in vitro : studying tonically active neurons controlling vagal outflow in rodent brainstem slices / Stefan Trapp and Klaus Ballanyi -- Anatomically "calibrated" isolated respiratory networks from newborn rodents / Araya Ruangkittisakul [and others] -- Physiological properties of human fetal cortex in vitro / Anna R. Moore [and others] -- Histological characterization of physiologically determined fast-spiking interneurons in slices of primate dorsolateral prefrontal cortex / Kenneth N. Fish [and others] -- Neural circuits underlying circadian oscillations in mammals : clocks in a dish / Takahiro J. Nakamura [and others] -- Osmoregulatory circuits in slices and en bloc preparations of rodent hypothalamus / Tevye J. Stachniak [and others] -- Establishing in vivo-like activity in rat cerebellar cells maintained in vitro / Bruce E. McKay [and others] -- Spontaneous rhythmic activity in the adult cerebral cortex in vitro / Maria V. Sanchez-Vives -- Living human brain slices : network analysis using voltage-sensitive dyes / Tilman Broicher and Erwin-Josef Speckmann -- Intact in vitro preparations of the neonatal rodent cortex : analysis of cellular properties and network activity / Heiko J. Luhmann and Werner Kilb -- Spontaneous neural network oscillations in hippocampus, cortex, and locus coeruleus of newborn rat and piglet brain slices / Chase Kantor [and others] -- Neuronal networks in the in vitro isolated guinea pig brain / Marco de Curtis [and others] -- Study of respiratory chemoreflexes using a novel dual-perfused rodent preparation / Trevor A. Day and Richard J.A. Wilson -- Defined medium organotypic cultures of spinal cord put 'pain in a dish' / James E. Biggs [and others] -- Rodent isolated spinal cord preparations to examine motor output / Sravan Mandadi [and others].
  • 2007From: Ovid
    [edited by] William S. Pease, Henry L. Lew, Ernest W. Johnson.
    Anatomy for the electromyographer / Denise L. Davis and Ernest W. Johnson -- The essentials of the needle EMG exam / Vivek Kadyan, Ernest W. Johnson, and Denise L. Davis -- Basic nerve conduction techniques / Robert J. Weber and Margaret Turk -- Electrophysiology / Jun Kimura -- Instrumentation / Sanjeev D. Nandedkar -- Advanced needle EMG methods / Erik Stålberg -- Quality improvement and reporting in electrodiagnostic medicine / William S. Pease -- Pictorial guide to muscles and surface anatomy / Henry L. Lew and Su-Ju Tsai -- Pictorial guide to nerve conduction techniques / Henry L. Lew and Su-Ju Tsai -- Entrapment neuropathies and other focal neuropathies (including carpel tunnel syndrome) / Lawrence R. Robinson -- Evaluation of the patient with suspected peripheral neuropathy / James W. Albers -- Electrodiagnostic approach to patients with suspected radiculopathy / Timothy R. Dillingham -- Evaluation of the patient with suspected myopathy / Albert C. Clairmont, Bakri Elsheikh, and Yousef M. Mohammad -- Neuromuscular complications of critical illness: evaluation of the patient with a suspected critical illness neuromuscular disorder / Daniel M.Clinchot -- Evaluation of the patient with suspected neuromuscular junction disorder / William J. Litchy -- Pediatric considerations in electromyography / Rosalind J. Batley.
    Also available: Print – 2007
  • v. 1-2, 1885.From: Google Books
    Fulltext (v.2 1885)From: Google Books
    by W. Morrant Baker and Vincent Dormer Harris.
    Also available: Print – v. 1-2, 1885.
  • 1885-From: Google Books
    by W. Morrant Baker and Vincent Dormer Harris.
    Also available: Print – 1898.
  • 1821-1833From: BIUM
    Fulltext (v. 2)From: BIUM
    Fulltext (v. 3)From: BIUM
    Fulltext (v. 4)From: BIUM
    Fulltext (v. 5)From: BIUM
    Fulltext (v. 6)From: BIUM
    Fulltext (v. 7)From: BIUM
    Fulltext (v. 8)From: BIUM
    Fulltext (v. 9)From: BIUM
    editionem curavit Carolus Gottlob Kühn ... ; [cum indice cura F.G. Assmanni].
  • edited by Ole H. Petersen.
    Status: Not Checked OutLane Catalog Record
    Cell physiology -- Cellular communication -- Introduction to the nervous system -- Signalling in the nervous system -- Muscle -- Sensory systems -- Special senses -- Motor system -- Higher nervous functions -- Pain -- Endocrine system -- Reproduction -- Blood -- Introduction to the cardiovascular system -- Cardiovascular system--the heart -- Vascular system -- Cardiovascular regulation, regional circulation and circulatory adjustments -- Respiration -- Digestive system -- Kidney -- Fluid and electrolyte balance -- Energy metabolism -- Temperature regulation -- Exercise.
  • 1880-From: Google Books
    Landois, L.; Rosemann, Hans, Ulrich; Rosemann, R.
    Also available: Print – 1885.
  • 1880-From: Google Books
    Landois, L.; Rosemann, Hans Ulrich; Rosemann, R.
    Also available: Print – 1887.
  • 2007From: Springer
    edited by Anita H. Payne, Matthew P. Hardy.
  • Yusuf Ozuysal.
    Neurons have a limited dynamic range. To more efficiently encode the large range of natural inputs, neural circuits adapt by dynamically changing their output range as a function of the input statistics. Variance adaptation provides an informative example of this process, whereby neurons change their response characteristics as a function of variance of their input. When their input distribution changes, sensory systems shift and scale their response curves to efficiently cover the new range of input values and they focus on different segments of the frequency spectrum, for example by choosing to average out the noise in a low signal-to-noise ratio environment by low-pass filtering their input and sacrificing resolution. In multiple sensory systems, adaptation to the variance of a sensory input changes the sensitivity, kinetics and average response over timescales ranging from < 100 ms to tens of seconds. Here we present a simple biophysically relevant model of retinal contrast adaptation that accurately captures both the membrane potential response and all adaptive properties. The adaptive component of this model is a first-order kinetic process of the type used to describe ion channel gating and synaptic transmission. We conclude that all adaptive dynamics can be accounted for by depletion of a signaling mechanism, and that contrast adaptation can be explained as adaptation to the mean of a thresholded signal. A diverse set of adaptive properties that implement theoretical principles of efficient coding can be generated by a single type of molecule or synapse with just a few microscopic states. The LNK model helps to highlight important aspects of adaptation by letting us focus on individual computational blocks separately. By using the LNK model, we investigate the source of the adaptive process in On-Off retinal ganglion cells, which show strong changes in their kinetics as a function of contrast. By analyzing properties of the LNK model, we conclude that most of the adaptive effect is due to differences in the threshold of the two pathways, with a smaller contribution from different adaptive kinetics. Adaptive temporal decorrelation in the retina arises due to differential thresholding in two parallel neural pathways.
  • 2015From: Springer
    Gil Atzmon, PhD editor.
    The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
    Also available: Print – 2015
  • Zuley Rivera Alvidrez.
    Any time we move, our brains solve the difficult problem of translating our motor intentions to muscle commands. Understanding how this computation takes place, and in particular, what role the motor cortex plays in movement generation, has been a central issue in systems neuroscience that remains unresolved. In this thesis, we took an unconventional approach to the analysis of cortical neural activity and its relationship to executed movements. We used dimensionality reduction to extract the salient patterns of neural population activity, and related those to the muscle activity patterns generated during arm reaches to a grid of targets. We found that salient neural activity patterns appeared to tightly reflect muscle activity patterns with a biologically-plausible lag. We also applied our analyses to movements that were planned before being executed, and found that a muscle-framework view of the cortical activity was consistent with previously-described predictions of movement kinematics based on the state of the cortical population activity. Overall, our results elucidate remarkable simplicity of the motor-cortical activity at the population level, despite the complexity and heterogeneity of individual cell's activities.
  • v. 1-2, 2014From: Springer
    v. 2From: Springer
    Bernd Nilius, Veit Flockerzi, editors.
    v. 1. TRPs: truly remarkable proteins -- The TRCP subfamily -- TRPC1 -- TRPC2 -- TRPC3: a multifunctional signaling molecule -- TRPC4 and TRPC4-containing channels -- TRPC5 -- TRPC6: physiological function and pathophysiological relevance -- Transient receptor potential canonical 7 (TRPC7) -- The TRPV subfamily -- TRPV1 -- TRPV2 -- TRPV3 -- The TRPV4 channel -- TRPV5, a Ca2+ channel for the fine tuning of Ca2+ reabsorption -- TRPV6 channels -- The TRPM subfamily -- TRPM1 -- TRPM2 -- TRPM3 -- TRPM4 -- TRPM5 -- TRPM6 -- TRPM7 -- TRPM8 -- The TRPA1, TRPML and TRPP subfamily -- TRPA1 -- TRPML1: an ion channel in the lysosome -- TRPML2 and mucolipin evolution -- TRPML3 -- TRPP subfamily and polycystin-1 proteins -- v. 2. TRPs as special cell sensors -- Temperature sensing with TRPs -- TRPs in mechano-sensing and volume regulation -- TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) -- Photosensitive TRPs -- TRPs in taste and chemesthesis -- TRPs and Pain -- TRPs in hearing -- TRPs in olfaction -- General topics -- Evolutionary conserved, multitasking TRP channels-lessons from worms and flies -- Structural biology of TRP channels -- High-resolution views of TRPV1 and their implications for the TRP channel superfamily -- Physiological functions and regulation of TRPC channels -- The TRPCs-STIM1-orai interaction -- The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins -- TRPs: modulation by drug-like compounds -- TRP channels in reproductive (neuro)endocrinology -- Modulation of TRP ion channels by venomous toxins -- Phosphoinositide regulation of TRP channels -- TRP modulation by natural compounds -- What do we really know and what do we need to know: some controversies, perspectives, and surprises.
  • 2013From: Cambridge
    [edited by] Daniel Truong, Dirk Dressler, Mark Hallett, Christopher Zachary.
    "This book tries to answer many of the questions posed above with the contributions of a team of international experts. As in the first edition, the emphasis in this book is on technique, so it is richly endowed with illustrations concerning accurate access techniques to help physicians become facile and fully competent"--Provided by publisher.
  • 2011From: Springer
    edited by Luigia Romano ... et al. ; foreward by Giuseppe Brancato.
    Lungs and Interstitial Network -- Airways -- Pulmonary Arteries and Veins -- Aorta and Supra-aortic Trunks -- Bronchial Arteries and Vena Cava -- Pleura and Pericardium -- Mediastinal Compartments, Lymphatic System, and Esophagus -- Heart and Coronary Arteries -- Chest Wall -- Diaphragm and Abdominal and Pelvic Walls -- Peritoneal Cavity -- Splanchnic Arteries -- Iliac Arteries and Abdominal Aorta -- Renal Arteries -- Inferior Vena Caval System -- Venous Portal Circle -- Abdominal Lymphatic System -- Gastroduodenal Tract -- Small Intestine -- Colon -- Liver -- Biliary System -- Spleen -- Extraperitoneal Spaces -- Pancreas -- Adrenal Glands -- Kidneys and Ureters -- Urinary Bladder -- Bony Pelvis -- Muscular Pelvis and Pelvic Floor -- Pelvic Space -- Female Pelvis: Uterus, Ovaries, and Ligaments -- Prostate and Seminal Vescicles.
  • Melinda Joy Cromie.
    This dissertation addressed two challenges in musculoskeletal biomechanics. The first challenge was to understand the function of total knee prostheses after implantation in patients. Motions of the knee following total knee replacement affect a patient's ability to perform daily activities, such as walking and rising from a chair, and affect the longevity of the prosthesis. The millimeter-scale translations of the joint are difficult to measure with noninvasive methods such as analysis of skin mounted markers. We addressed this challenge by measuring passive knee kinematics using a surgical navigation system. The specific goal was to isolate the effects of posterior cruciate ligament removal on knee motion after total knee arthroplasty. We measured knee kinematics intraoperatively while the surgeon passively flexed and extended the knee at four surgical time points: after initial exposure, after removing the anterior cruciate ligament, after removing the posterior cruciate ligament, and after implanting the prosthesis. We calculated anterior femoral translation and the flexion angle at which femoral rollback began. We found that removing the posterior cruciate ligament introduced abnormal anterior translation, doubling the anterior translation from the initial exposure (from 5.1 +/- 4.3 mm to 10.4 +/- 5.1 mm) and increasing the flexion angle at which femoral rollback began (from 31.2 +/- 9.6 degrees to 49.3 +/- 7.3 degrees). Implanting the prosthesis did not restore the motion measured at initial exposure. Relative to the cruciate-deficient case, prosthesis implantation increased the amount of anterior translation (to 16.1 +/- 4.4 mm) and did not change the flexion angle at which femoral rollback began. Abnormal anterior translation was observed in low and mid flexion (0-60 degrees) after removing the posterior cruciate ligament, and normal motion was not restored by the posterior stabilized prosthesis. These findings can be used to interpret further motion analysis during functional tasks and to guide improvements in prosthesis design. The second challenge was to understand how the motions of sarcomeres, the contractile units of muscle, affect the force-generating capacity of muscles in humans. Sarcomere length over a muscle's range of motion in the body is an important factor that affects muscle excursions and force-generating capacity. The relationship between sarcomere length and joint angle can be altered in disease, and measurement of this relationship is important for guiding treatments. Second-harmonic generation (SHG) microendoscopy has recently been developed in our laboratories to image sarcomeres and measure their lengths in humans. However, technical challenges such as motion artifacts and low signal have thus far prevented this novel technique from being used to quantify sarcomere lengths in humans. We discovered that an excitation wavelength of 960 nm maximized image signal; this enabled an image acquisition rate of 3 frames-per-second, which decreased motion artifact. We then used microendoscopy to directly image sarcomeres in the extensor carpi radialis brevis (ECRB) in seven healthy adults with the wrist in 45 degrees extension and 45 degrees flexion. We determined the average sarcomere lengths and the length variability of in-series sarcomeres from the SHG images. Sarcomere lengths in 45 degrees wrist extension were 2.93 +/- 0.29 microns (mean +/- standard deviation) and increased to 3.58 +/- 0.19 microns in 45 degrees flexion. Within local regions of the fibers the standard deviation of sarcomere lengths in series was 0.20 +/- 0.07 microns. These measurements agree with measurements in the same muscle using laser diffraction. The lengths of sarcomeres in series within a small region of an individual fiber can vary substantially. This study demonstrates the suitability of SHG microendoscopy for imaging muscle microstructure and illustrates the potential of this technology to address a new class of questions about muscle architecture and remodeling in humans. The ability to measure sarcomere operating lengths in humans without surgery enables us to diagnose the involvement of specific muscles in neuromuscular disorders, and to design surgeries that will optimize an individual patient's outcome. Measurement of sarcomere operating length will also enable a new class of research questions to be addressed about the adaptations of muscles over time in response to surgeries or pharmacologic treatments.
  • 2010From: ScienceDirect
    J. David Sweatt.
    This book represents the first step at beginning to put together the complex puzzle of the molecular basis of memory. Sweatt creates a framework of thinking about synaptic plasticity and memory at the molecular level; one which recognizes and begins to incorporate this extreme biochemical complexity into our thinking about memory.
  • 2010From: Springer
    Andre Kamkin, Irina Kiseleva, editors ; forward by Vadim V. Fedorov.
  • 2015From: Springer
    Giuliano Gentili, Mario Di Napoli.
    This atlas systematically reviews motor conduction studies of the median nerve, from pilot human studies in peripheral nerve conduction during the 1950s through to the most recent scientific evidence. Descriptions are provided of a wealth of motor nerve conduction techniques that were reproduced in the laboratory, including both the originally proposed methods and variants. The techniques are organized according to practical criteria for ease of reference. Attention is focused especially on those techniques which have shown higher sensitivity and specificity in the diagnosis of compressive mononeuropathies like carpal tunnel syndrome (CTS)and on the most widely accepted guidelines, recommendations, quality measures, and electrodiagnostic classifications. The volume is completed with a detailed, well-illustrated glossary explaining the more commonly used terms in electrodiagnostic medicine (EDX). The atlas is primarily intended for residents and professionals in Neurology, as well as rehabilitation physicians and clinical neurophysiologists. The detailed descriptions of techniques and their practical use will also make the book an invaluable tool for novices and clinical neurophysiology technicians.
  • [edited by] Walter F. Boron, MD, PhD, professor, David N. and Inez Myers/Antonio Scarpa Chairman, Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, Emile L. Boulpaep, MD, professor, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut.
    Status: Not Checked OutLane Catalog Record
    Medical Physiology, in its updated 2nd edition, firmly relates molecular and cellular biology to the study of human physiology and disease. Drs. Walter Boron and Emile Boulpaep and a team of leading physiologists present practical, accurate coverage emphasizing the clinical implications of the material. Each chapter explains the principles and organization of each body system, while more than 1400 high-quality, full-color line drawings and prominently featured clinical examples clarify every concept. This exceptionally detailed and comprehensive guide to physiology is ideal for a rich, straightforward, state-of-the-art understanding of this essential subject.
  • edited by Rodney A. Rhoades, David R. Bell.
    Status: Not Checked OutLane Catalog Record
  • 2015From: ScienceDirect
    Ewart Carson, Caludio Cobelli.
    1. An introduction to modelling methodology / Claudio Cobelli and Ewart Carson -- 2. Control in physiology and medicine / B. Wayne Bequette -- 3. Deconvolution / Giovanni Sparacino [and three others] -- 4. Structural identifiability of biological and physiological systems / Maria Pia Saccomani -- 5. Parameter estimation / Paolo Magni and Giovanni Sparacino -- 6. New trends in nonparametric linear system identification / Gianluigi Pillonetto and Giuseppe De Nicolao -- 7. Population modelling / Paolo Magni, Alessandra Bertoldo and Paolo Vicini -- 8. Systems biology / Ruoting Yang [and three others] -- 9. Reverse engineering of high-throughput genomic and genetic data / Barbara Di Camillo and Gianna Toffolo -- 10. Tracer experiment design for metabolic fluxes estimation in steady and nonsteady state / Andrea Caumo and Claudio Cobelli -- 11. Stochastic models of physiology / Boris Kovatchev and Stephen Patek -- 12. Probabilistic modelling with Bayesian networks / Francesco Sambo, Fulvia Ferrazzi and Riccardo Bellazzi -- 13. Mathematical modelling of pulmonary gas exchange / Dan S. Karbing [and three others] -- 14. Mathematical models for computational neuroscience / Mauro Ursino, Filippo Cona and Elisa Magosso -- 15. Insulin modelling / Morten Gram Pedersen and Claudio Cobelli -- 16. Glucose modelling / Chiara Dalla Man and Claudio Cobelli -- 17. Blood-tissue exchange modelling / Paolo Vicini and James B. Bassingthwaighte -- 18. Physiological modelling of positron emission tomography images / Alessandra Bertoldo and Claudio Cobelli -- 19. Tumor growth modelling for drug development / Monica Simeoni [and four others] -- 20. Computational modelling of cardiac biomechanics / Emiliano Votta and Alberto Redaelli -- 21. Downstream from the heart left ventricle : aortic impedance interpretation by lumped and tube-load models / Roberto Burattini -- 22. Finite element modelling in musculoskeletal biomechanics / Zimi Sawacha and Bernhard Schrefler -- 23. Modelling for synthetic biology / Lorenzo Pasotti, Susanna Zucca and Paolo Magni.
  • 2011From: Springer
    Undurti N. Das.
    The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
  • Hannah Margareta Teichmann.
    Nervous system function, from sensory perception to motor control and cognition, requires the correct wiring of neural circuits during development. The establishment of these circuits consists of the growth and guidance of signal-sending axons and signal-receiving dendrites to their correct targets. Despite being exposed to the same molecular environment, a neuron's axon and dendrites have different morphologies and targets. Using the C. elegans DA9 motoneuron we explore mechanisms of dendrite growth and how a dendrite-specific response is achieved to a cue regulating axons and dendrites. We found that DA9 dendrite development is spatially and temporally distinct from the axon. While the axon grows embryonically, the dendrite develops postembryonically. Characterizing DA9 dendrite growth in larvae, adults and body size mutants suggests that it is not driven by size, but rather by a local cue. A candidate approach to identify this cue taught us that the guidance cue UNC-6/Netrin is required for both axon and dendrite development in DA9. The UNC-6 repulsive receptor UNC-5 repels the axon from the ventral nerve cord, while the attractive receptor UNC-40 is dendritically enriched and promotes antero-posterior dendrite growth. While ventrally secreted UNC-6 instructs axon guidance, dorsal or even membrane-tethered UNC-6 can support dendrite development. Surprisingly, the kinase PAR-4/LKB1 is selectively required for UNC-40 signaling in dendrite outgrowth. Finally, we found that the C-terminal motor kinesin KLP-16 also promotes DA9 dendrite growth and that its enrichment at the DA9 dendrite distal tip may be partially regulated by PAR-4/LKB1. These data suggest that axon and dendrite of one neuron interpret common environmental cues with different receptors and downstream signaling pathways.
  • 2006From: Springer
    edited by Mark L. Latash and Francis Lestienne.
  • 2016From: ClinicalKey
    Harvey S. Singer, Jonathan W. Mink, Donald L. Gilbert, Joseph Jankovic.
    Basal ganglia anatomy, biochemistry, and physiology -- Cerebellar anatomy, biochemistry, physiology, and plasticity -- Classification of movement disorders -- Diagnostic evaluation of children with movement disorders -- Motor assessments -- Transient and developmental movement disorders in children -- Tics and tourette syndrome -- Motor stereotypies -- Paroxysmal dyskinesias -- Chorea, athetosis, and ballism -- Dystonia -- Myoclonus -- Tremor -- Ataxia -- Parkinsonism -- Hereditary spastic paraplegia -- Inherited metabolic disorders with associated movement abnormalities -- Movement disorders in autoimmune diseases -- Movements that occur in sleep -- Cerebral palsy -- Movement disorders and neuropsychiatric conditions -- Drug-induced movement disorders in children -- Functional (psychogenic) movement disorders -- Appendixes. Drug appendix -- Search strategy for genetic movement disorders -- Video atlas.
  • 2012From: ScienceDirect
    2012From: ClinicalKey
    edited by Joseph A. Hill and Eric N. Olson ; section editors, Kathy K. Griendling ... [et al.].
  • 2010From: Springer
    Dilson E. Rassier, editor.
    Also available: Print – 2010
  • 2013From: ClinicalKey
    Victor Dubowitz, Caroline A. Sewry, Anders Oldfors ; with contribution on toxic and drug-induced myopathies by Russell Lane.
    The Procedure of Muscle Biopsy -- Histological and Histochemical Stains and Reactions -- Normal Muscle -- Histological and Histochemical changes -- Ultrastructural Changes -- Immunohistochemistry and Immunoblotting -- How to Read A Biopsy -- Classification of Neuromuscular Disorders -- Neurogenic Disorders -- Muscular Dystrophies and Allied Disorders I: Duchenne and Becker Muscular Dystrophy -- Muscular Dystrophies and Allied Disorders II: Limb-Girdle Muscular Dystrophies -- Muscular Dystrophies and Allied Disorders III: Congenital Muscular Dystrophies and Associated Disorders -- Muscular Dystrophies and Allied Disorders IV: Emery-Dreifuss Muscular Dystrophy and Similar Syndromes -- Muscular Dystrophies and Allied Disorders V: Facioscapulohumeral, Myotonic and Oculopharyngeal Muscular Dystrophies -- Myopathies with Vacuoles -- Metabolic Myopathies I: Glycogenoses and Lysosomal Myopathies -- Metabolic Myopathies II: Lipid-Related Disorders and Mitochondrial Myopathies -- Myopathies Associated with Systemic Disorders and Ageing -- Ion Channel Disorders -- Myasthenic Syndromes -- Inflammatory Myopathies -- Toxic and Drug-Induced Myopathies -- Appendix 2: Useful Websites.
  • Samuel Richard Hamner.
    Human running is a bouncing gait during which the body mass center slows and lowers during the first half of the stance phase; muscle forces then accelerate the mass center forward and upward in the second half of stance. Muscle-driven simulations of running allow us to determine how muscle forces give rise to the accelerations of the body mass center. Before this dissertation, it remained unclear how muscle forces modulate accelerations of the mass center at various running speeds as three-dimensional, muscle-driven simulations of running had yet been created or analyzed. Thus the goal of this dissertation was to better understand the functional role of muscles by generating the first three-dimensional, muscle-driven simulation of the running gait cycle and quantifying how muscles contribute to vertical and fore-aft accelerations of the body mass center over a range of running speeds. Initially, I created a three-dimensional, muscle-driven simulation of a single subject running at a single speed and quantitatively described how individual muscles accelerated the subject's body mass center. The simulation was generated with a musculoskeletal model driven by 92 musculotendon actuators of the lower extremities and torso. The model also included torque-driven arms, which allowed me to investigate the contributions of arm motion to running dynamics. This single simulation revealed that during the first half of the stance phase, quadriceps was the largest contributor to backward and upward accelerations of the mass center. During the second half of stance, the soleus and gastrocnemius muscles were the greatest contributors to forward and upward accelerations of the mass center. To determine how individual muscle forces in these simulations acted to generate the ground reaction force, and the resulting accelerations of the body mass center, it is necessary to model ground contact. The accelerations computed in such simulation analyses are sensitive to the model used to represent contact between the foot and ground. To have confidence in our ability to interpret muscle function, a ground contact model should be able to reproduce experimentally measured ground reaction forces and moments. I show that a rolling constraint accurately reproduces the measured ground reaction forces and moments in an induced acceleration analysis of muscle-driven simulations for walking, running, and crouch gait. I also evaluated other contact models used in previous studies (e.g., point and weld constraints) to illustrate that these models can produce inaccurate reaction moments and lead to contradictory interpretations of muscle function, including the contribution of major muscles, like the vasti and soleus, to fore-aft and upward mass center accelerations. To determine how muscles modulate ground reaction forces and mass center accelerations over a range of running speeds, I created muscle-driven simulations of ten subjects running at four speeds: 2 m/s, 3 m/s, 4 m/s, and 5 m/s. An induced acceleration analysis was used to determine the contribution of each muscle to body mass center accelerations. Analysis of the simulations revealed that soleus provides the greatest upward mass center acceleration at all running speeds, with a peak upward acceleration of 19.8 m/s/s (i.e., the equivalent of approximately 2.0 body weights of ground reaction force) at 5.0 m/s. Soleus also provided the greatest contribution to forward mass center acceleration, with contributions increasing from 2.5 m/s/s to 4.0 m/s/s as running speed increased from at 2.0 m/s to 5.0 m/s. Quadriceps produced the largest backward mass center acceleration; at 5.0 m/s peak contribution from quadriceps was 80% of total peak backward acceleration. At higher running speeds, greater velocity of the legs produced larger vertical angular momentum about the mass center, while vertical angular momentum from arm swing simultaneously increased to counterbalance that of the legs. The ability to reproduce the results of a study is an essential principle of the scientific method. However, reproducing results of simulation studies remains challenging because the software, models, and data used to create and analyze the simulations are generally not freely available. Thus, to promote the utilization and acceptance of simulations in movement science, I have provided open-access to the models, data, and subject-specific simulations developed for this dissertation at and The data and simulations can be visualized and results can be reproduced in OpenSim (, a freely-available biomechanics simulation package.
  • 2006From: Springer
    [edited by] Helen Sink.
    An introduction to muscle development in drosophila / Helen Sink -- The muscle pattern of drosophila / Volker Hartenstein -- Mesoderm formation in the drosophila embryo / Noriko Wakabayashi-Ito and Y. Tony Ip -- Development of the cardiac musculature / Rolf Bodmer -- Development of the somatic gonad and fat bodies / Mark Van Doren -- Development of the larval visceral musculature / Hsiu-Hsiang Lee, Stephane Zaffran and Manfred Frasch -- Development of the larval somatic musculature / Ana Carmena and Mary Baylies -- Muscle morphogenesis: the process of embryonic myoblast fusion / Susan M. Abmayr and Kiranmai S. Kocherlakota -- Muscle attachment sites-where migrating muscles meet their match / Talila Volk -- Neuromuscular development: connectivity and plasticity / Louise Nicholson and Haig Keshishian -- Metamorphosis and the formation of the adult musculature / Devkanya Dutta and K. VijayRaghavan -- Molecular basis of muscle structure / Jim O. Vigoreaux -- Whole genome approaches to studying drosophila muscle development / Eileen E.M. Furlong -- Comparison of muscle development in drosophila and vertebrates / Michael V. Taylor.
  • 2013From: Wiley
    edited by Hans H. Goebel, Caroline A. Sewry, Roy O. Weller.
  • 2010From: Springer
    Siegfried Mense, Robert D. Gerwin, editors.
    Part 1. Myofascial pain syndrome -- Myofascial Pain Syndrome / Robert D. Gerwin -- Morphology of Myofascial Trigger Points: What Does a Trigger Point Look Like? / Siegfried Mense -- Introduction / Siegfried Mense and Robert D. Gerwin -- Part 2. Fibromyalgia syndrome -- Fibromyalgia Syndrome: Clinical Aspects and Management / Emma Guymer and Geoffrey O. Littlejohn -- Gender, Genetics, and Other Risk Factors Increasing Vulnerability to Fibromyalgia / Geoffrey O. Littlejohn -- Part 3. Other muscle pain syndromes -- Low Back Pain of Muscular Origin / Robert D. Gerwin -- Masticatory Muscle Pain / Sandro Palla and Mauro Farella -- Inflammatory Myopathies / Ingrid E. Lundberg and Li Alemo Munters -- Whiplash Injury, Muscle Pain and Motor Dysfunction / Jan Dommerholt -- Brain Imaging of Muscle Pain / Sandra Kamping and Herta Flor.
  • 2010From: Springer
    Siegfried Mense, Robert D. Gerwin, editors.
    Introduction / Siegfried Mense and Robert D. Gerwin -- Functional anatomy of muscle : muscle, nociceptors, and afferent fibers / Siegfried Mense -- Peripheral mechanisms of muscle pain : response behavior of muscle nociceptors and factors eliciting local muscle pain / Siegfried Mense -- Central nervous mechanisms of muscle pain : ascending pathways, central sensitization, and pain-modulating systems / Siegfried Mense -- Referral of musculoskeletal pain / Thomas Graven-Nielsen and Siegfried Mense -- Increased muscle tone as a cause of muscle pain / Siegfried Mense and Alfonse T. Masi -- Reorganized motor control due to muscle pain / Thomas Graven-Nielsen and Lars Arendt-Nielsen.
  • 2013From: ScienceDirect
    Hans Garten, guest editor for the international edition Joseph Shafer.
    Especially prepared for the international audience, the English language edition of this highly successful handbook describes Professional Applied Kinesiology muscle testing procedures. A departure from the classic understanding of muscle testing for weakness and rehabilitation, these procedures can be used for detecting more subtle, functional abnormalities. Included within the chapters are stretch tests and post-isometric relaxation procedures for the hypertonic, shortened muscle. Muscle anatomy and physiology are briefly recapped in order to enhance reader comprehension. The Muscle Testing Handbook describes testing procedures for almost 100 individual muscles in a unique, quick reference, template approach. In close collaboration with Dr. Garten, the German edition has been adapted for the English-language audience by Dr. Shafer, an American chiropractic colleague. This book is ideal for use by manual therapists, physiotherapists, osteopaths, chiropractors, sports scientists and neurology department staff worldwide. Clearly describes modern muscle test procedures The individual aspects of each muscle are easily compared by the use of well-illustrated templated descriptions A double-page spread design allows the reader a rapid, at-a-glance access to essential information Muscle anatomy and function are succinctly recapped in order to facilitate a complete understanding of the relevance and applicability of the individual test Classic Applied Kinesiology muscle tests for detecting functional abnormalities are well described along with stretch testing and post-isometric relaxation procedures for hypertonic, shortened muscles The importance of postural analysis for the assessment of specific muscle dysfunction is discussed and plainly described Illustrates painful spondylogenic reflex points (areas) for each muscle The role of distal acupuncture points and tendinomuscular meridians in maintaining normal muscle and muscle chain function are noted in accompanying diagrams The most commonly found trigger points, their referred pain patterns and relationship to nearby acupuncture points are clearly illustrated for each muscle Perfect for use in orthopaedics, neurology, general medicine, physiotherapy, chiropractic and osteopathy.
  • 2010From: CRCnetBASE
    Rui Diogo, Virginia Abdala.
    Chapter 1. Introduction and Aims -- Chapter 2. Methodology and Material -- Chapter 3. Muscles of Non-Osteichthyan Vertebrates -- Chapter 4. Head and Neck Muscles of Actinopterygians and Basal Sarcopterygians -- Chapter 5. From Sarcopterygian Fish to Modern Humans -- Chapter 6. Head and Neck Muscles of Amphibians -- Chapter 7. Head and Neck Muscles of Reptiles -- Chapter 8. Pectoral and Pectoral Fin Muscles of Actinopterygian and Sarcopterygian Fishes -- Chapter 9. From Sarcopterygian Fish to Modern Humans -- Chapter 10. Pectoral and Forelimb Muscles of Limbed Amphibians and Reptiles -- Chapter 11. General Comments.
  • 2011From: ScienceDirect
    volume editors, Robert C. Griggs and Anthony A. Amato.
    Overview of the muscular dystrophies / A.A. Amato and R.C. Griggs -- Dystrophinopathies / L.A. Morrison -- Sarcoglycanopathies / J. Kirschner and H. Lochmüller -- Congenital muscular dystrophies / S.E. Sparks and D.M. Escolar -- The collagen VI-related myopathies : Ullrich congenital muscular dystrophy and Bethlem myopathy / C.G. Bönnemann -- Limb-girdle muscular dystrophy 2A / E. Gallardo, A.Saenz and I.Iilla -- Dysferlinopathies / A.A. Amato and R.H. Brown Jr -- Other limb-girdle muascular dystrophies / A.A. Amato -- Limb-girdle muscular dystrophy 2H and the role of TRIM32 / P.B. Shieh, E. Kudryashova and M.J. Spencer -- Caveolinopathies : translational implications of caveolin-3 in skeletal and cardiac muscle disorders / E. Gazzerro, A. Bonetto, and C. Minetti -- Myofibrillar myopathies / D. Selcen and A.G. Engel -- Emery-Dreifuss muscular dystrophy / M. Puckelwartz and E.M. McNally -- Facioscapulohumeral dystrophy and scapuloperoneal syndromes / R.W. Orrell -- Oculopharyngeal muscular dystrophy / B. Brais -- Myotonic dystrophy types 1 and 2 / T. Ashizawa and P.S. Sarkar -- Distal muscular dystrophies / B. Udd.
  • 2016From: Springer
    J. Bryan Dixon, editor.
    Taking a multidisciplinary approach to a common and often frustrating problem for athletes and those with an active lifestyle, this book is the first of its kind, addressing muscular injuries to the posterior leg using an in-depth and expansive style that is uniquely dedicated to ensuring all content is explicitly linked to the practical care of patients with calf pain. It is divided thematically into three sections. The first section covers underlying principles involved in these issues, including anatomy, physiology, pathophysiology of injury and neurophysiology of musculoskeletal pain. Clinical assessment techniques and imaging are covered in the second section. The third section on treatment is the most expansive, discussing acute, sub-acute and chronic posterior leg muscle injuries, as well as surgical management, rehabilitation techniques, complementary medicine and special populations. Overall, the book is designed to use muscular injuries of the posterior leg to as a means to understand the assessment and treatment of muscular injuries more broadly. Taken together, it is the consummate source for orthopedists, doctors in sports medicine, podiatrists, rehabilitation professionals and primary care physicians who treat muscular injuries in the posterior leg, though readers will gain a conceptual and practical framework for the assessment and treatment of muscular injuries in general.
  • 2014From: Springer
    Elinor Mody, Elizabeth Matzkin, editors.
    Musculoskeletal Health in Women aims to provide fitness advice tailored to women. As women are more prone to specific injuries than men are, due to differences in hip and knee anatomy as well as hormonal differences, this book will provides a fully-illustrated and comprehensive overview of all aspects including energy availability (which is affected by eating disorders), osteoporosis, and menstrual function. Its multidisciplinary approach ensures that expertise is provided from disciplines such as psychiatry, physiatry, endocrinology, nutrition, rheumatology, orthopedics, physical therapy and radiology. Written by authors who have extensive experience working with women athletes, Musculoskeletal Health in Women addresses a full spectrum of issues related to the musculoskeletal health of women. It is of primary interest to women athletes and women embarking on a fitness regimen. Health professionals working in this area would also invariably benefit from the advice and guidance provided within these pages.
  • 2008From: Thieme Book
    Maximilian Reiser, Andrea Baur-Melnyk, Christian Glaser ; [translator, Stephanie Kramer].
    1. Tumors -- Osteoma -- Osteoid osteoma -- Enchondroma -- Osteochondoroma (cartilaginous exostosis) --Nonossifying fibroma -- Fibrous dysplasia (Jaffe-Lichtenstein Disease) -- Juvenile bone cyst -- Aneurysmal bone cyst -- Giant cell tumor (Osteoclastoma) -- Synovial chondromatosis (Reichel Syndrome) -- Bone hemangioma -- Paget Diesase (Ostetis Deformans) --Metastases -- Osteosarcoma -- Ewind sarcoma -- Multiple myeloma (plasmacytoma) -- Lymphoma of bone -- Neoplastic vertebral compression fracture -- Soft-tissue hemangioma -- Soft-tissue sarcoma -- Lipoma -- Pigmented villonodular synovitis -- Myositis ossificans -- 2. Inflammatory diseases -- Osteomyelitis -- Brodie abscess -- Rheumatoid arthritis -- Psoriatic arthritis/psoriatic arthropathy -- Septic arthritis -- Gout (gouty arthritis) -- Ankylosing spondylitis -- Spondylitis and spondylodiskitis -- Complex regional pain syndrome -- 3. Degenerative disease -- Osteoarthritis -- Osteochondrosis -- Intervertebral disk herniation -- Spinal canal stenosis -- Spondylolysis/spondylolisthesis -- Implant loosening -- Diffuse idiopathic skeletal hyperostosis -- Neuropathic osteoarthropathy (charcot joint) -- 4. Metabolic disorders -- Osteoporosis -- Rickets -- Osteomalacia -- Hyperparathyroidism -- 5. Developmental disorders -- Madelund deformity -- Hip dysplasia -- Tibia vara (Blount Disease) -- Slipped capital femoral epiphysis -- Club foot (talipes equinovarus) -- Scoliosis -- Osteogenesis imperfecta -- Osteopetrosis (Marble Bone Disease) -- Scheuermann Disease -- 6. Osteonecrosis -- Perthes Disease -- Osteonecrosis of the knee -- Lunatomalacia (Kienbock Disease) -- Femoral head necrosis -- Osteochondritis dissecans -- Bone infarct -- 7. Intra-articular lesions -- Meniscal lesions -- Cruciate ligament tears -- Cartilage lesions -- Labral lesions -- Rotator cuff lesions -- 8. Ligament and tendon injuries -- Lateral ankle ligament rupture -- Achilles tendon rupture -- Avulsion fracture -- Shoulder impingement -- 9. Fractures and dislocations -- Clavicle fracture -- Acromioclavicular separation -- Proiximal humerus fractures -- Shoulder dislocation -- Radial head fracture -- Pediatric condylar fractures -- Distal radius fracture -- scaphoid fracture -- Triquetrum fracture -- Skier's thumb (gamekeeper's thumb) -- Dens fracture -- Femoral neck fracture -- pertrochanteric femoral fracture -- Patella fracture -- Tibial plateau fracture -- Ankle joint fractures -- Calcaneus fracture -- Fractures of the base of the fifth metatarsal -- Occult fracture -- Stress fracture - Pseudarthrosis.
  • 2015From: ClinicalKey
    [edited by] Thomas L. Pope, Hans L. Bloem, Javier Beltran, William B. Morrison, David J. Wilson.
  • 2009From: ClinicalKey
    Clyde A. Helms, Nancy M. Major, Mark W. Anderson, Phoebe A. Kaplan, Robert Dussault.
    Basic principles of musculoskeletal MRI -- Marrow -- Tendons and muscles -- Peripheral nerves -- Musculoskeletal infections -- Arthritis and cartilage -- Tumors -- Osseous trauma -- Temporomandibular joint -- Shoulder -- Elbow -- Wrist and hand -- Spine -- Hips and pelvis -- Knee -- Foot and ankle.
    Also available: Print – 2009
  • 2017From: ClinicalKey
    [edited by] Gerard A. Malanga, Kenneth Mautner.
    Introduction : an evidence-based approach to the musculoskeletal physical examination / Gerard Malanga, Kenneth Mautner -- Reliability and validity of physical examinations / Heather R. Galgon, Larry H. Chou -- Sensory, motor, and reflex examination / Jeffrey A. Strakowski, Matthew J. Fanous, John Kincaid -- Physical examination of the cervical spine / Lisa Huynh, David J. Kennedy -- Physical examination of the shoulder / Edward McFarland, Jay E. Bowen, Amrut Borade, Gerard A. Malanga, Tutankhamen Pappoe -- Physical examination of the elbow / Kenneth Montgomery, Teo Mendez-Zfass, Andrew Willis -- Examination of the wrist and hand / Keith Bengston -- Physical examination of the lumbar spine and sacroiliac joint / David Nathan Woznica, Joel Press -- Physical examination of the pelvis and hip / Ken Mautner, J.W. Thomas Byrd, Walter Sussman, Brian Krabak -- Physical examination of the knee / Anthony Beutler, Francis G. O'Connor -- Physical examination of the foot and ankle / Maj Ross A. Schumer, Mederic M. Hall, Annunziato (Ned) Amendola.
  • 2010From: Thieme Book
    edited by Glenn M. Garcia.
    RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical. RadCases covers: cardiac imaging, interventional radiology, musculoskeletal imaging, neuro imaging, chest imaging, pediatric imaging, gastrointestinal imaging, breast imaging, nuclear medicine, ultrasound imaging, head and neck imaging, and genitourinary imaging. Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment. Each case begins with the clinical presentation on the right-hand page; simply turn the page for imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more. Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book's specialty - 250 cases in total! Learn your cases, diagnose with confidence and pass your exams.
  • 2010From: Thieme Book
    [edited by] Vikram S. Dogra, Diana Gaitini.
    With an emphasis on the accuracy and dynamic nature of no-radiation ultrasound, leading clinicians from around the world provide practical guidance on how to combine different multiplanar imaging modalities in the analysis and diagnosis of common musculoskeletal disorders. Organized by body region, each of the 13 chapters follows a consistent, easy-to-reference format. The authors guide the reader through clinical indications, technical guidelines, and normal anatomy followed by information on degenerative diseases, inflammatory conditions, traumatic injuries, tumors, and various other musculoskeletal problems. Clear, high-resolution ultrasound images appear side by side with MRI, and in some cases CT, images to teach and train readers how to perform musculoskeletal ultrasound in clinical practice while simultaneously sharpening their diagnostic skills.
  • 2013From: Springer
    Ke Xu, Susumu Terakawa.
    In 1961, neurobiologists found that the conduction velocity of the nerve impulse in the giant nerve fiber of the Penaeus shrimp abdominal nerve cord was over 200 m/s, the highest speed of information transmission ever observed in the animal kingdom. The peculiar myelin sheath with its unique nodal structure and the electrical properties of the nerve fibers of the shrimp have continued to be investigated for a quarter of century and are now fully described in this book. The investigation dispels the commonly held belief that the fastest recorded impulse conduction is about 120 m/s in the thickest vertebrate myelinated nerve fibers. In the shrimp, researchers found a completely novel type of functional node in the giant fiber which they designated as the fenestration node. In portions of the myelinated fiber, the fenestration node furnished the sites of excitation. Also discovered was a new strategy for increasing impulse conduction in the shrimp. The book includes a section on the formation of the fenestration node and the discovery of a strategy that allows the shrimp to escape its predators by an action of the fastest velocity. The data presented in this volume on the myelin sheath of invertebrates present a new direction for this field and a rich source of information for neurobiologists worldwide.
  • 2013From: ScienceDirect
    edited by Dominik Irnich ; translated by Jackie K. Jones.
    Edited by Dominik Irnich, MD, this clearly written and fully illustrated multi-contributor volume offers practical, comprehensive coverage of the subject area ranging from the latest scientific research findings to practical usage of current manual therapy techniques. Including the latest information from centres of excellence throughout the world, this new book is suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, physiotherapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine. Offers practical and clinically relevant information to all practitioners and therapists working in the field Edited by an international expert in pain management and trigger point therapy Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Carefully prepared by a worldwide team of clinically active and research oriented contributors to provide helpful and clinically relevant information Presents the latest research findings for many aspects of trigger point therapy Provides a holistic view of patient care including the importance of patient communication and psychological aspects of pain control Provides a handy reference for rapid and effective diagnosis and treatment of trigger points Highlights the 65 most important muscles in a comprehensive practical style which includes anatomy, symptoms, pain patterns, physical examination and strategies for effective treatment Offers an ideal resource for training courses in trigger point injection, osteopathy, manual therapy and acupuncture Suitable for osteopathic physicians, osteopaths, chiropractors, manual therapists, acupuncturists and massage therapists as well as general physicians working in primary care, physical medicine, rehabilitation, pain management and internal medicine.
  • 2012From: Springer Protocols
    edited by Joseph X. DiMario.
    Isolation and characterization of human fetal myoblasts/ Ariya D. Lapan and Manuela Gussoni -- Skeletal muscle satellite cells : background and methods for isolation and analysis in a primary culture system / Maria Elena Danoviz and Zipora Yablonka-Reuveni -- Isolation of muscle stem cells by fluorescence activated cell sorting cytometry / Alessandra Pasut, Paul Oleynik, and Michael A. Rudnicki -- Mouse and human mesoangioblasts : isolation and characterization from adult skeletal muscles / Mattia Quattrocelli [and others] -- Direct electrical stimulation of myogenic cultures for analysis of muscle fiber type control / Eric J. Cavanaugh, Jennifer R. Crew, and Joseph X. DiMario -- Single muscle-fiber isolation and culture for cellular, molecular, pharmacological, and evolutionary studies / Judy E. Anderson, Ashley C. Wozniak, and Wataru Mizunoya -- Somite unit chronometry to analyze teratogen phase specificity in the paraxial mesoderm / Sarah J. Venters and Charles P. Ordahl -- Analysis of skeletal muscle development in drosophila / Ginny R. Morriss [and others] -- Immunocytochemistry to study myogenesis in zebrafish / Nathan C. Bird, Stefanie E. Windner, and Stephen H. Devoto -- Immunofluorescent localization of proteins in Caenorhabditis elegans muscle / Kristy J. Wilson, Hiroshi Qadota, and Guy M. Benian -- Resistance loading and signaling assays for oxidative stress in rodent skeletal muscle / Stephen E. Alway and Robert G. Cutlip -- Analysis of skeletal muscle hypertrophy in models of increased loading / Sue C. Bodine and Keith Baar -- Protein overexpression in skeletal muscle using plasmid-based gene transfer to elucidate mechanisms controlling fiber size / Chia-Ling Wu and Susan C. Kandarian -- In vivo measurement of muscle protein synthesis rate using the flooding dose technique / Marta L. Fiorotto, Horacio A. Sosa Jr., and Teresa A. Davis -- Recombinant adeno-associated viral vector production and purification / Jin-Hong Shin, Yongping Yue, and Dongsheng Duan -- Generation of lentiviral vectors for use in skeletal muscle research / Christophe Pichavant and Jacques P. Tremblay -- Generating tamoxifen-inducible Cre alleles to investigate myogenesis in mice / Christoph Lepper and Chen-Ming Fan -- Gene profiling studies in skeletal muscle by quantitative real-time polymerase chain reaction assay / Shephali Bhatnagar, Siva K. Panguluri, and Ashok Kumar -- Analysis of lipid profiles in skeletal muscles / Vassilis Mougios and Anatoli Petridou -- Proteomic analysis of dystrophic muscle / Caroline Lewis, Philip Doran, and Kay Ohlendieck -- Detection of calcium release via ryanodine receptors / Jerry P. Eu and Gerhard Meissner -- Measurement of calcium release due to inositol trisphosphate receptors in skeletal muscle / Mariana Casas, Francisco Altamirano, and Enrique Jaimovich -- Detection of calcium sparks in intact and permeabilized skeletal muscle fibers / Noah Weisleder, Jingsong Zhou, and Jianjie Ma -- Analysis of calcium transients in cardiac myocytes and assessment of the sarcoplasmic reticulum Ca(2+)-ATPase contribution / Anand Mohan Prasad and Giuseppe Inesi -- Analysis of muscle gene transcription in cultured skeletal muscle cells / Charis L. Himeda, Phillip W.L. Tai, and Stephen D. Hauschka -- Analysis of fiber-type differences in reporter gene expression of [beta]-gal transgenic muscle / Phillip W.L. Tai [and others] -- Determination of gene promoter activity in skeletal muscles in vivo / Sarah M. Senf and Andrew R. Judge -- Determination of miRNA targets in skeletal muscle cells / Zhan-Peng Huang, Ramón Espinoza-Lewis, and Da-Zhi Wang -- ShRNA-mediated gene knockdown in skeletal muscle / Muriel Golzio, Jean-Michel Escoffre, and Justin Teissié -- Detection of NF-[kappa]B activity in skeletal muscle cells by electrophoretic mobility shift analysis / Jason M. Dahlman and Denis C. Guttridge -- Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays / Yasuyuki Ohkawa [and others] -- An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number / Yasuyuki Ohkawa [and others] -- ChIP-enriched in silico targets (ChEST), a ChIP-on-chip approach applied to analyzing skeletal muscle genes / Guillaume Junion and Krzysztof Jagla.
  • 2007From: ScienceDirect
    volume editors, Frank L. Mastaglia and David Hilton-Jones.
    Also available: Print – 2007
  • 2010From: Karger
    volume editor, O. Walusinski.
    The first complete and authoritative book on yawning.
  • 2009From: ScienceDirect
    Hanns-Christian Gunga.
  • 2006From: Springer
    Jim O. Vigoreaux.
  • 2011From: ClinicalKey
    Nancy M. Major, Michael D. Malinzak ; illustrations by Frank H. Netter ; contributing illustrators, Carlos A.G. Machado, Kristen Wienandt Marzejon.
    Musculoskeletal Anatomy is the first title in the brand new Netter's Correlative Imaging series. Series editor and specialist in musculoskeletal imaging Dr. Nancy Major and coauthor, Michael Malinzak, presents Netter's beautiful and instructive paintings and illustrated cross sections created in the Netter style side-by-side with high-quality patient MR images created with commonly used pulse sequences to help you visualize the anatomy section by section. With in-depth coverage and concise descriptive text for at-a-glance information and access to correlated images online, this atlas is a comprehensive reference that's ideal for today's busy imaging specialists. View upper and lower limbs in sagittal, coronal, and axial view MRs of commonly used pulse sequences, each slice complemented by a detailed illustration in the instructional and aesthetic Netter style. Find anatomical landmarks quickly and easily through comprehensive labeling and concise text highlighting key points related to the illustration and image pairings. Correlate patient data to idealized normal anatomy in the approximately 30 cross-sections per joint that illustrate the complexities of musculoskeletal anatomy.
  • 2015From: ClinicalKey
    Susan E. Mulroney and Adam K. Myers ; illustrations by Frank H. Netter; contributing illustrators, Carlos A. G. Machado, John A. Craig, James A. Perkins.
  • Daniel L. Kimmel.
    For many decisions, we must explicitly compare the value of two or more goods being offered. However, often decisions are not between multiple goods, but rather between a single offer and the choice to pass on that offer, such as when deciding to buy a new car, marry a significant other, or read this abstract! For these decisions the relevant comparison is between the expected benefit of the offer and its associated cost. We studied cost-benefit decisions in the macaque monkey while recording from single neurons in the orbitofrontal cortex (OFC), which has been implicated previously in decisions between competing goods. We found that the animal was sensitive to the balance of cost and benefit. That is, his willingness to accept an offer increased monotonically as we increased the benefit while keeping the cost constant. We found that the OFC represented task-relevant information--such as benefit, choice, and expected outcome--in a complex manner. These signals were mixed at the level of single neurons, but by examining the population response, we found separable ensembles of neurons that represented each of these task relevant variables. Moreover, different sets of neurons appeared to represent these signals for discrete temporal epochs within and between trials, which may correspond to distinct functional processes revealed by behavior. Taken together, we offer a novel view of how a population of neurons may collectively represent value and choice information and how that population may transform the representation dynamically over time.
  • Michael C. Ke.
    An understanding of the neural patterns available to guide plasticity in vivo is needed to bridge our knowledge of synaptic plasticity to its function in learning. I investigated the patterns of neural activity that trigger plasticity in vivo in a simple cerebellum-dependent motor learning task, adaptation of the vestibulo-ocular reflex (VOR), with the specific goal of determining which neurons carry the instructive signals that trigger plasticity in the circuit for the VOR. The VOR stabilizes images on the retina during head turns by using vestibular signals to generate compensatory smooth eye movements in the opposite direction of head motion. Motor learning maintains the accuracy of the VOR by modifying the gain and timing of the reflex whenever retinal image motion is persistently associated with head movements. In the laboratory, motor learning in the VOR can be acutely induced by pairing head movements with motion of a visual stimulus. Two specific hypotheses have been proposed regarding the neural signals that guide motor learning in the VOR. One suggests that learning is guided by the activity of Purkinje cells, the output neurons of the cerebellum[1]. The other hypothesis suggests that learning is guided by climbing fiber input to the Purkinje cells[2-4]. Previous experiments addressing which neurons carry instructive signals have typically used a single training condition for increasing VOR gain and a single training condition for decreasing VOR gain[5, 6]. These two training conditions each elicited Purkinje cell and climbing fiber signals that carried information about the required direction of learning, and since the patterns of neural activity were consistent with both hypotheses, data are needed to provide constraints that could discriminate between the hypotheses. The goal of my research is to provide such constraints by recording the patterns of neural activity present in Purkinje cells and climbing fibers during a broader range of visual-vestibular stimuli that induce motor learning in the VOR. I induced motor learning in the VOR by pairing head movements with complex visual stimuli. These novel behavioral manipulations elicited many different combinations of Purkinje cell and climbing fiber signals, allowing us to evaluate how each of these neural signals contributes to learning. My data demonstrated that neither instructive signals in the climbing fibers nor Purkinje cells are necessary for learning, although either signals appear to be sufficient to support learning. Additionally, the largest changes in VOR gain occurred when both signals were present, suggesting that the changes mediated by Purkinje cell-triggered mechanisms and climbing-fiber triggered mechanisms are additive in their effects at the behavioral level. These findings are evidence that motor learning in the VOR is accomplished by parallel and independent operation of climbing fiber-triggered and Purkinje cell-triggered plasticity mechanisms. If cerebellum dependent motor learning is supported by the parallel and independent operation of plasticity mechanisms, similar motor learning need not be accomplished in a stereotyped fashion, but rather similar motor learning can be achieved by engaging distinct subsets of plasticity mechanisms each under the control of a unique instructive signal.
  • Matthew T. Kaufman.
    The ultimate purpose of the motor system is clear: it exists to control the body. However, despite the motor system being among the longest-studied brain structures, it remains unclear how -- mechanistically -- motor cortex performs this function. Here, a mechanistic approach was taken to investigate how primary motor cortex (M1) and dorsal premotor cortex (PMd) control movement. That is, the goal was to elucidate the dynamics of the motor cortex 'machine.' Monkeys were trained in reaching tasks, and neural signals were recorded from their brains as they performed them. Two broad classes of analysis were used. First, cell-by-cell analyses were combined with cell-type analyses, which permitted examining the activity patterns of excitatory and inhibitory neurons separately. Second, techniques based on dynamical systems analysis (such as dimensionality reduction) were applied, which permitted analysis of neural populations as a whole and abstraction to a somewhat higher level of system function. Three major results and a technical advance are presented. Firstly, we investigated how it is possible for an animal to hold still even as neural activity in motor cortex changes drastically during preparation for the upcoming movement. We found that, contrary to common assumptions, there does not appear to be a 'gate' comprised of high inhibition during preparation. Instead, using the dynamical systems perspective, we found that preparatory activity has a special structure such that it remains in intrinsically muscle neutral, 'iso-force' patterns. Secondly, we searched for coherent dynamics in the movement-time activity of motor cortex. We found that motor cortex appears to obey a relatively simple set of dynamics, dominated by oscillatory patterns. Moreover, the exact neural trajectory is heavily determined ('seeded') by the immediately preceding preparatory activity. In order to causally perturb these dynamics with patterned stimulation and cell-type specificity, we then developed a set of optogenetic techniques for use in primates. Finally, we investigated how the dynamics of the decision-making process are reflected in motor cortex. To do so, we combined a novel decision-making paradigm, many simultaneous neural recordings, and single-trial analytical techniques. Preliminary results are given for this final section, demonstrating the presence of vacillation in monkey decision-making. In summary, we found that preparation and movement can be understood as an oscillatory dynamical system seeded by preparatory activity that lives in an iso-force space, that inhibitory and excitatory neurons seem to play more similar roles in the dynamical system than might be expected, and that moment-by-moment processes of motor decision-making can be seen in motor cortex.
  • 2008From: Springer Protocols
    edited by Leslie P. Weiner.
    Definitions and criteria for stem cells / Leslie P. Weiner -- Neural stem cells and the future treatment of neurological diseases : raising the standard / Jaime Imitola and Samia J. Khoury -- Neural differentiation of human embryonic stem cells / Mirella Dottori and Martin F. Pera -- Generating neurons from stem cells / Andreas Androutsellis-Theotokis ... [et al.] -- Isolation of neural stem and precursor cells from rodent tissue / Yuanyuan Wu ... [et al.] -- Adult rodent spinal cord-derived neural stem cells : isolation and characterization / Lamya S. Shihabuddin -- Adult neural stem cells / Rossella Galli, Angela Gritti, and Angelo L. Vescovi -- Olfactory ensheathing cells : isolation and culture from the neonatal olfactory bulb / Susan C. Barnett and A. Jane Roskams -- Culturing olfactory ensheathing cells from the mouse olfactory epithelium / Miranda Richter, Kathryn Westendorf, and A. Jane Roskams -- Production and characterization of immortal human neural stem cell line with multipotent differentiation property / Seung U. Kim ... [et al.] -- Preparation of neural progenitors from bone marrow and umbilical cord blood / Shijie Song and Juan Sanchez-Ramos -- Production of neurospheres from CNS tissue / Gregory P. Marshall II ... [et al.] -- Nuclear transfer to study the nuclear reprogramming of human stem cells / Shigeo Saito ... [ et al.] -- Clonal analyses and cryopreservation of neural stem cell cultures / Angela Gritti, Rossella Galli, and Angelo L. Vescovi -- Telomere neurobiology / Mark P. Mattson, Peisu Zhang, and Aiwu Cheng -- Chromosomal mosaicism in neural stem cells / Suzanne E. Peterson ... [et al.] -- In vitro assays for neural stem cell differentiation : induction of dopaminergic phenotype / Marcel M. Daadi -- In vitro migration assays of neural stem cells / Pascale Durbec .. [et al.] -- Measuring apoptosis in neural stem cells / Brett T. Lund and Eve E. Kelland -- Markers of adult neural stem cells / Eric Wexler -- Differential gene expression in ES-derived neural stem cells by using RT-PCR / Nicole Slawny, Crystal Pacut, and Theresa E. Gratsch -- Microfluidic devices for high-throughput gene expression profiling of single hESC-derived neural stem cells / Yan Chen and Jiang F. Zhong -- Electroporation strategies for genetic manipulation and cell labeling / Terence J. Van Raay, Rhonda T. Lassiter, and Michael R. Stark -- Novel and immortalization-based protocols for the generation of neural CNS stem cell lines for gene therapy approaches / Luciano Conti and Elena Cattaneo -- Identification of newborn cells by BrdU labeling and immunocytochemistry in vivo / Sanjay S. Magavi and Jeffrey D. Macklis -- Immunocytochemical analysis of neuronal differentiation / Sanjay S. Magavi and Jeffrey D. Macklis -- Neuroanatomical tracing of neuronal projections with Fluoro-Gold / Lisa A. Catapano, Sanjay S. Magavi, and Jeffrey D. Macklis -- Labeling stem cells in vitro for identification of their differentiated phenotypes after grafting into the CNS / Qi-lin Cao, Stephen M. Onifer, and Scott R. Whittemore -- Optimizing stem cell grafting into the CNS / Scott R. Whittemore ... [et al.] -- Routes of stem cell administration in the adult rodent / Alison E. Willing ... [et al.]
  • 2014From: Springer
    Hugo Merchant, Victor de Lafuente, editors.
    "The study of how the brain processes temporal information is becoming one of the most important topics in systems, cellular, computational, and cognitive neuroscience, as well as in the physiological bases of music and language. During the last and current decade, interval timing has been intensively studied in humans and animals using increasingly sophisticated methodological approaches. The present book will bring together the latest information gathered from this exciting area of research, putting special emphasis on the neural underpinnings of time processing in behaving human and non-human primates. Thus, Neurobiology of Interval Timing will integrate for the first time the current knowledge of both animal behavior and human cognition of the passage of time in different behavioral context, including the perception and production of time intervals, as well as rhythmic activities, using different experimental and theoretical frameworks."--Publisher's description (excerpt).
    Also available: Print – 2014
  • 2006From: Springer
    Daniel P. Cardinali, S.R. Pandi-Perumal, editors.
    Deals with endocrine regulation of the behavioral state control. This title addresses a wide spectrum of sleep/wakefulness phenomena (both animals and humans), including pathogenesis, diagnosis, and management. It provides a summary of important issues in the neuroendocrine correlates of sleep/wakefulness.
  • 2016From: Springer
    Boris I. Prilutsky, Donald H. Edwards, editors.
    For over a century, research has yielded enormous amounts of quantitative information about animal motor systems. Yet our understanding of neural control mechanisms of animal balance and locomotion remains cursory and fragmented. This book aims to change that. This is the first book on neuromechanical modeling, a tool that integrates the massive body of knowledge in computational models and complex motor behaviors to reveal the mechanisms by which these behaviors emerge. The majority of research groups working in this area have contributed chapters to this book. The book covers a wide range of topics from theoretical studies linking the organization of spinal reflex pathways and central pattern generating circuits with morphology and mechanics of the musculoskeletal system, to detailed neuromechanical models of balance and locomotor control, to analyses of nonlinear transformations of neural signals by the musculoskeletal system. This book can be used as an introductory guide to this new and exciting area of computational neuroscience research. .
  • 2008From: ClinicalKey
    Tulio E. Bertorini.
    In this unique book, Dr. Bertorini guides you through more than 100 cases that demonstrate the diagnosis and management of a wide range of common and rare neuromuscular disorders. No other reference boasts such a large array of clinical studies devoted to all areas of this broad topic! Each case study reviews the etiologies, pathogenesis, differential diagnosis, and management of a particular disorder, helping you not only recognize its presentation, but also determine a diagnosis and the best treatment plans for your patients. You2ll also find expert guidance on the basic mechanisms of neuromuscular disorders, clinical examination, and diagnostic tests--including EMG, muscle biopsy, genetic testing, and more. More than 100 detailed case studies explore both common and rare neuromuscular disorders and the treatment protocols for each, equipping you with the knowledge you need to confidently manage any challenge. Each case includes a summary of important points or highlights of the study. Case studies are arranged either by complaint or by diagnosis so that you can successfully manage your patients with or without an initial diagnosis. Comprehensive coverage of EMGs and nerve conduction studies and other diagnostic tests, including muscle and nerve biopsies and genetic testing, helps you accurately diagnose nerve, muscle, and neuromuscular transmission disorders. Detailed discussions of treatment plans and commonly used drugs enhance your management of autoimmune disorders, painful neuropathy, dysautonomia, and other neuromuscular disorders. A reader-friendly format takes you step by step through the diagnosis and treatment of neuromuscular disorders, from the basic anatomy and physiology of the nerve and muscle through to clinical evaluation, diagnostic testing, and therapy. More than 350 high-quality illustrations, including full-color patient photographs, biopsies, and EMG tracings, make complex concepts easier to understand and apply.
  • 2013From: Cambridge
    John H.J. Wokke, Peter A. van Doorn, Jessica E. Hoogendijk, and Marianne de Visser.
    Introduction: approach to the patient -- Part I: Motor neurone diseases -- Case 1: Classical amyotrophic lateral sclerosis -- Case 2: ALS with frontotemporal dementia -- Case 3: Primary lateral sclerosis -- Case 4: Progressive muscular atrophy -- Case 5: Kennedy disease -- Case 6: Spinal muscular atrophy type III, Kugelberg-Welander disease -- Case 7: Post-polio syndrome -- Case 8: Spinal dural fistula -- Part II: Neuropathies -- Case 9: Charcot-Marie-Tooth disease type 1A -- Case 10: Hereditary neuropathy with liability to pressure palsy -- Case 11: Charcot-Marie-Tooth disease type 2A, mitofusinopathy -- Case 12: X-linked Charcot-Marie-Tooth disease -- Case 13: Hereditary sensory and autonomic neuropathy type 4 -- Case 14: Guillain-Barre syndrome -- Case 15: Miller-Fisher syndrome -- Case 16: Chronic inflammatory demyelinating polyneuropathy -- Case 17: Multifocal motor neuropathy -- Case 18: Peripheral nerve hyperexcitability syndrome, Morvan's syndrome -- Case 19: Vasculitic neuropathy -- Case 20: Neuropathy and ataxia caused by IgM gammopathy -- Case 21: Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes -- Case 22: Subacute sensory paraneoplastic neuropathy and ganglionopathy -- Case 23: Neurolymphomatosis -- Case 24: Diabetic neuropathy -- Case 25: Alcohol neuropathy -- Case 26: HIV neuropathy -- Case 27: Lyme radiculoneuritis -- Case 28: Lepromatous neuropathy -- Case 29: Toxic iatrogenic neuropathy -- Case 30: Idiopathic neuralgic amyotrophy -- Case 31: Small nerve fibre neuropathy -- Case 32: Critical illness polyneuropathy -- Case 33: Chronic idiopathic axonal polyneuropathy -- Part III: Neuromuscular Junction Disorders -- Case 34: Classic myasthenia gravis -- Case 35: Myasthenia gravis with autoantibodies to MuSK -- Case 36: Lambert-Eaton myasthenic syndrome -- Case 37: Congenital myasthenic syndrome: slow channel syndrome -- Part IV: Myopathies -- Case 38: Becker muscular dystrophy -- Case 39: Caveolinopathy, including limb girdle muscular dystrophy type 1C -- Case 40: Limb girdle muscular dystrophy type 2A, calpainopathy -- Case 41: Limb girdle muscular dystrophy type 2I, fukutin-related protein deficiency -- Case 42: Emery-Dreifuss muscular dystrophy -- Case 43: Facio-scapulo-humeral dystrophy -- Case 44: Miyoshi myopathy, dysferlinopathy, limb girdle muscular dystrophy type 2B -- Case 45: Distal myopathy with rimmed vacuoles, hereditary inclusion body myopathy -- Case 46: Oculopharyngeal muscular dystrophy -- Case 47: A woman with a family history of muscle weakness and severe cardiac complaints, desminopathy -- Case 48: Late-onset congenital myopathy caused by a mutation in the RYR1 gene, central core disease -- Case 49: Bethlem myopathy -- Case 50: Myotonic dystrophy type 1, Curschmann-Steinert disease -- Case 51: Myotonic dystrophy type 2, proximal myotonic myopathy -- Case 52: Becker myotonia, chloride channelopathy -- Case 53: Glycogen storage disease type 2, Pompe disease -- Case 54: Glycogen storage disease type 5, McArdle disease -- Case 55: Mitochondrial disease: progressive ophthalmoplegia -- Case 56: Myositis -- Case 57: Sporadic inclusion body myositis -- Case 58: Sarcoid myopathy -- Case 59: Hypothyroid myopathy.
  • 2011From: ClinicalKey
    Tulio E. Bertorini.
    Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world's leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life. Effectively treat your patients using the latest management tools and targeted therapeutic strategies. Manage all neuromuscular disorders as well as resulting complications through comprehensive coverage of diagnosis and evaluations, treatments, and outcomes. Apply the multi-disciplinary approach of an expert in clinical neuromuscular care and a team of world-renown contributors. Easily refer to tools for diagnosis, treatment algorithms, and drug tables included throughout the text. Pinpoint the problem to provide better quality of life for patients.
  • 2015From: ClinicalKey
    edited by Basil T. Darras, H. Royden Jones, Jr., Monique M. Ryan, Darryl C. De Vivo.
  • 2010From: Springer
    Thomas Fuchs-Buder.
  • 2011From: ClinicalKey
    [edited by] Francis O. Walker, Michael S. Cartwright.
    This book use of ultrasound as an alternative to electrodiagnosis in the evaluation of neuromuscular disorders through detailed descriptions and clear illustrations. Drs. Francis Walker and Michael S. Cartwright discuss techniques for visualizing muscles and nerves without painful testing for better patient compliance and more efficient diagnosis. This book covers the use of ultrasound as an alternative to electrodiagnosis for the evaluation of neuromuscular disorders-using illustrations to compare and contrast the two techniques. It provides lucid descriptions of how the clinical and electrodiagnostic examinations can be refined, improved, and enhanced to minimize patient discomfort and to maximize the optimal patient evaluation.
  • 2006From: Springer
    J. Hannibal, J. Fahrenkrug.
  • 2010From: Springer
    edited by Enrique A. Lopez-Poveda, Alan R. Palmer, Ray Meddis.
  • 2014From: Springer
    edited by Gary R. Lewin, Bruce D. Carter.
    This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington's syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
  • 2007From: Springer
    Yoshiki Nishizawa, Hirotoshi Morii, and Jean Durlach, eds.
    Overview -- Magnesium homeostasis -- Nutrition -- Epidemiology -- Exercise -- Metabolic syndrome -- Cardiovascular disease -- Skeletal diseases and calcium metabolism -- Kidney -- Neurology -- Magnesium in dental medicine -- Magnesium in neurology and psychiatry -- Veterinary medicine.
  • 2014From: Future Med
    editors, Bente Danneskiold-Samsøe, Else Marie Bartels.
    Novel insights into the pathophysiology and treatment of fibromyalgia / Bente Danneskiold-Samsøe & Else Marie Bartels -- The history of fibromyalgia / Bente Danneskiold-Samsøe & Else Marie Bartels -- Pain in fibromyalgia / Kirstine Amris -- Pain assessment in fibromyalgia / Else Marie Bartels & Bente Danneskiold-Samsøe -- Fatigue and fibromyalgia / Philip Mease -- Genetic influence on fibromyalgia / Laia Rodriguez-Revenga, Elisa Docampo, Antonio Collado & Montserrat Mila -- Biomarkers in fibromyalgia / Nurcan Üçeyler & Claudia Sommer -- Assessment of activities of daily living in fibromyalgia / Eva E. Wæhrens -- Assessment of muscle strength and muscle function in fibromyalgia / Kaisa Mannerkorpi & Petri Salo -- Clinical assessment of fibromyalgia / Bente Danneskiold-Samsøe & Else Marie Bartels -- Treatment options for fibromyalgia / David A. Williams & Daniel J. Clauw -- Index.
  • 2007From: CRCnetBASE
    edited by Geoffrey Burnstock, Timothy R. Arnett.
  • 2005From: CRCnetBASE
    edited by Janos Zempleni, Krishnamurti Dakshinamurti.
    Also available: Print – 2005
  • 2016From: Springer
    Roy J. Shephard, Catrine Tudor-Locke, editors.
    1. Physical activity and optimal health: the callenge to epidemiology -- 2. A history of physical activity measurement in epidemiology -- 3. Outputs available from objective monitors -- 4. Protocols for data collection, management and treatment -- 5. Resources for data interpretation and reporting -- 6. New information on population activity patterns revealed by objective monitoring -- 7. Can the epidemiologist learn more from sedentary behaviour than from the measurement of physical activity? -- 8. New perspectives on activity/ disease relationships yielded by objective monitoring -- 9. Excessive appetite vs. inadequate physical activity in the pathology of obesity: evidence from objective monitoring -- 10. Objective monitoring and the challenge of defining dose/response relationships for the prevention of chronic disease -- 11. The economic benefits of increased physical activity as seen through an objective lens -- 12. Limitations of current objective monitors and opportunities to overcome these problems -- 13. Objective measurement in physical activity surveillance: present role and future potential -- 14. Self-report and direct measures of health: bias and implications -- 15. Conclusions and future directions.
  • 2007From: Karger
    volume editors, Robin M. Daly, Moira A. Petit.
    Osteoporosis : a paediatric concern? / R.A. Faulkner, D.A. Bailey -- The biomechanical basis of bone strength development during growth / S.A. Kontulainen ... [et al.] -- The effect of exercise on bone mass and structural geometry during growth / R.M. Daly -- Evidence for an interaction between exercise and nutrition for improved bone health during growth B. Specker, M. Vukovich -- Gene-environmental interactions in the skeletal response to nutrition and exercise during growth / J.-P. Bonjour ... [et al.] -- The effect of energy balance on endocrine function and bone health in youth / C. Zanker, K. Hind -- Risk factors for fractures in normally active children and adolescents / A. Goulding -- Does exercise during growth prevent fractures in later life? / M.K. Karlsson -- Lessons learned from school-based skeletal loading intervention trials : putting research into practice / J.M. Hughes, S.A. Golner, M.A. Petit.
    Also available: Print – 2007
  • Sung-Yon Kim.
    Anxiety, a sustained state of apprehension in the absence of a specific and imminent threat, is critical for an organism to survive in an environment with unpredictable risks. In disease states, however, anxiety becomes severely debilitating; anxiety disorders represent the most common psychiatric diseases (28% lifetime prevalence). Despite the high prevalence of anxiety disorders, current treatments are often ineffective and have severe side-effects, such as addiction, pointing to the need for a deeper understanding of anxiety circuits. The amygdala and extended amygdala have long been hypothesized to play a central role in anxiety, but the function of the intra- and inter-connections of the amygdala and extended amygdala circuits are unclear, largely due to the lack of appropriate tools. With the advent of optogenetics, which was pioneered in the Deisseroth lab, and with the evolution of virus- or promoter-based targeting strategies, it is now possible to manipulate a specific circuit element with unprecedented precision and to identify its function in behavior. The first part of this thesis illustrates the application of optogenetics to identify an intra-amygdala circuit element that decreases anxiety. The second part explores the functional circuitry of the bed nucleus of the stria terminalis (BNST), a key component of the extended amygdala. We studied the roles of its input from the amygdala and outputs to the hypothalamus and brainstem areas in the anxious state. Here, the term 'anxious state' is used to emphasize that anxiety is a behavioral state consisting of distinct features, such as behavioral risk-avoidance and changes in respiration rate. We sought to find circuit elements mediating each distinct feature of the anxious state. The data provided by this thesis furthers our understanding of the function and dysfunction of anxiety circuitry. The approach that we employed here for functional circuit mapping may be applicable to the dissection of other behavioral states, such as fear and aggression.
  • Joanna Hochberg Mattis.
    Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to also play an important role in the circuit; these neurons fire at either low or high frequency, reflecting hippocampal network activity during theta oscillations or ripple events, respectively. Since the hippocamposeptal projection is sparse and long-range, the impact of high or low frequency hippocampal input on septal physiology has not been addressable with classical electrophysiological or pharmacological techniques. In order to understand the contribution of defined neuronal subtypes, such as hippocamposeptal neurons, to brain function, our laboratory has developed a technique termed optogenetics, which integrates genetic targeting and optical stimulation to achieve temporally precise manipulation of genetically and spatially defined cell types in intact tissue. Optogenetics employs light sensitive microbial proteins, including ion pumps and channels that can elicit or inhibit action potentials. Optogenetics has already proved invaluable to neuroscience, but several key limitations to its application have become apparent: First, increasingly diverse optogenetic tools allow more versatile control over neural activity, but since new tools have been developed in multiple laboratories and tested across different preparations it is difficult to draw direct comparisons between them. As a result, it has become increasingly challenging for end users to select the optimal reagents for their experimental needs. Second, as the power of genetically encoded interventional and observational tools for neuroscience expands, the boundary of experimental design is increasingly defined by limits in selectively expressing these tools in specific cell types. To date, cell-type has primarily referred to genetic specificity, achieved with promoter-driven expression either in transgenic animals or in viruses. This approach is limited in its ability to define a 'cell type': cells may be targeted based on only a single parameter, and genetic targeting does not take into account anatomic connectivity, in many cases the most salient feature of a target population. The aim of this thesis is thus three-fold: 1) To interrogate frequency-dependent signaling in the hippocamposeptal pathway, using optogenetics to gain cell-type specific, temporally-precise control over hippocamposeptal fibers, 2) To systematically compare microbial opsins under matched experimental conditions to extract essential principles and identify key parameters for the conduct, design and interpretation of experiments involving optogenetic techniques, and 3) To develop new viral and molecular strategies to target cells of interest based on both genetic and topological parameters. The investigation of the hippocamposeptal projection will increase our understanding of the larger circuit of which it is a part, and will also illustrate the importance of firing frequency in neuronal signaling. The tool development described will be useful for future work investigating the hippocamposeptal pathway in particular, and more generally for a broad variety of applications of optogenetics to neuroscience.
  • Daniel James Dickinson.
    A fundamental characteristic of metazoans is the formation of a simple, polarized epithelium. In higher animals, the structural integrity and functional polarization of simple epithelia require a cell-cell adhesion complex containing a classical cadherin, the Wnt-signaling protein [Beta]-catenin and the actin-binding protein [Alpha]-catenin. I have investigated the evolutionary origins of epithelial cell polarity and of the cadherin-catenin complex. I show that the non-metazoan Dictyostelium discoideum forms a polarized epithelium that is essential for multicellular development. Although D. discoideum lacks a cadherin homolog, I have identified and characterized an [Alpha]-catenin ortholog that binds a [Beta]-catenin-related protein. Both proteins are essential for formation of the epithelium, polarized protein secretion and proper multicellular morphogenesis. Thus the organizational principles of metazoan multicellularity may be more ancient than previously recognized, and the role of the catenins in cell polarity predates the evolution of Wnt signaling and classical cadherins.
  • 2010From: ScienceDirect
    2010From: ClinicalKey
    [edited by] Eric S. Orwoll, John P. Bilezikian, Dirk Vanderschueren.
    Section 1. Essentials of bone biology -- The biochemistry of bone : composition and organization / Adele L. Boskey -- Bone remodeling : cellular activities in bone / David W. Dempster, Hua Zhou, Shi Shou Lu -- Assessment of bone turnover in men using biochemical markers / Patrick Garnero, Pawel Szulc -- Fundamentals of mineral homeostasis / David A. Hanley, K. Shawn Davison -- The mechanical properties of bone / David P. Fyhrie -- Essentials of bone biology : assessment of bone architecture / Thomas F. Lang -- Section 2. Development and growth of the male skeleton -- Skeletal growth in males / Qingju Wang, Ego Seeman -- Pubertal growth of the male skeleton / Vincent Gilsanz, Stefano Mora -- The effects of sex steroids on bone growth / Giampiero I. Baroncelli, Silvano Bertelloni -- Nutritional basis of skeletal growth / Connie M. Weaver, Elizabeth Haney -- Physical activity and skeletal growth / Heather M. Macdonald, Heather A. McKay, Melonie Burrows -- Section 3. Skeletal genetics -- The genetics of peak bone mass / Luigi Gennari, Robert F. Klein, Serge Ferrari -- Section 4. Aging and the male skeleton -- Age-related changes in bone remodeling and microarchitecture / Roger Zebaze, Ego Seeman -- Markers of bone remodeling and the aging skeleton / Serge Cremers, Christian Meier, Markus J. Seibel -- Alterations in mineral metabolism in the aging male / Shonni J. Silverberg, Bismruta Misra -- Changes in bone size and geometry with aging / Pawel Szulc -- Aging and bone loss / Steven Boonen ... [et al.] -- The effect of age on material properties / Charles H. Turner, Matthew R. Allen, David B. -- Section 5. Nutritional issues -- Calcium, bone strength and fractures / Laura A.G. Armas, Robert P. Heaney, Joan M. Lappe -- Vitamin D and bone / Roger Bouillon ... [et al.] -- Role of dietary protein in bone growth and bone loss / Rene Rizzoli -- Section 6. Sex steroids and the skeleton in men -- Section 7. Fractures in men -- Section 8. Metabolic bone disease in men -- Section 9. Diagnostic approach -- Section 10. Therapy.
  • 2008From: Springer
    Giuseppe Valacchi, editor ; Paul A. Davis, co-editor.
  • 2005From: Springer
    edited by Paul Okunieff, Jacqueline Williams, Yuhchyau Chen.
    Also available: Print – 2005
  • 2007From: Springer
    David J. Maguire, Duane F. Bruley, David K. Harrison (eds.).
    Also available: Print – 2007
  • 2009From: Springer
    Per Liss, Peter Hansell, Duane F. Bruley, David K. Harrison, editors.
    Air and fire : Carl Wilhelm Scheele, Torbern Bergman, the Royal Society of Sciences and the discovery of oxygen in Uppsala in 1772 / Lars-Olof Sundelöf -- Mathematical modeling of the interactiion betwen oxygen, nitric oxide and superoxide / Donald G. Buerk -- Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation / Andrew G. Pinder ... [et al.] -- Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions / Thomas E. Ingram ... [et al.] -- Nitrite-induced improved blood circulation associated with an increase in a pool of RBN-NO with NO bioactivity / Joseph M. Rifkind ... [et al.] -- The control of oxidative phosphorylation in the adrenal gland (Y1) cell line / James E.J. Murphy and Richard K. Porter -- Replication of murine mitochondrial DNA following irradiation / Hengshan Zhang ... [et al.] -- Effects of anesthesia on brain mitochondrial function, blood flow, ionic and electrical activity monitored in vivo / Nava Dekel ... [et al.] -- The influence of flow redistribution on working rat muscle oxygenation / Louis Hoofd and Hans Degens -- Heterogeneity of capillary spacing in the hypertrophied plantaris muscle from young-adult and old rats / Hans Degens, Christopher I. Morse, and Maria T.E. Hopman -- Microvascularity of the lumbar erector spinae muscle during sustained prone trunk extension test / Rammohan V. Maikala and Yagesh N. Bhambhani -- Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle / Rob C.I. Wüst, Sarah L. Gibbings, and Hans Degens -- Novel therapeutic approach targeting the HIF-HRE system in the kidney / Masaomi Nangaku -- Carotid body sensory discharge and glomus cell HIF-1[alpha] are regulated by a common oxygen sensor / S. Lahiri ... [et al.] -- Impact of reactive oxygen species on the expression of adhesion molecules in vivo / Oliver Thews ... [et al.] -- Mini sensing chip for point-of-care acute myocardial infarction diagnosis utilizing micro-electro-mechanical system and nano-technology / Jianting Wang ... [et al.] -- A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics" / Yoshihiro Uto ... [et al.] -- Zymogen protein C concentrate for safer heterozygote surgery, "I am a guinea pig!" / Duane F. Bruley -- Steady state redox levels in cytochrome oxidase : relevance for in vivo near infrared spectroscopy (NIRS) / Chris E. Cooper ... [et al.] -- Bicuculline-induced seizures : a challenge for optical and biochemical modeling of the cytochrome oxidase CUa NIRS signal / Chris E. Cooper ... [et al.] -- A method to calculate arterial and venous saturation from near infrared spectroscopy (NIRS) / Jan Menssen ... [et al.] -- Development of a dynamic test phantom for optical topography / Peck H. Koh, Clare E. Elwell, and David T. Delpy -- Numerical simulation of oxygen transport in cerebral tissue / Toshihiro Kondo ... [et al.] -- Non-invasive estimation of metabolic flux and blood flow in working muscle : effect of blood-tissue distribution / Nicola Lai ... [et al.] -- Oxygen extraction index measured by near infrared spectroscopy : a parameter for monitoring tissue oxygenation? / Oskar Baenziger ... [et al.] -- Non-invasive measurement of the superficial cortical oxygen partial pressure / Chris Woertgen ... [et al.] -- One sensor fits all : a new approach in monitoring brain physiology / H. Doll ... [et al.] -- Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue / Kazunori Oyama ... [et al.] -- Myocardial capillary net and blood constituents in streptozotocin (STZ-)-induced diabetic rats / Tomiyasu Koyama and Akira Taka -- Effects of proinsulin C-peptide on oxygen transport uptake and utilization in insulinopenic diabetic subjects : a review / Lina Nordquist and Sara Stridh -- Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging / Jenny Edlund ... [et al.] -- Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney / Malou Friederich ... [et al.] -- Iodinated contrast media decrease renomedullary blood flow : a possible cause of contrast media-induced nephropathy / Per Liss ... [et al.] -- C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats / Sara Stridh ... [et al.] -- Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents / Jerry D. Glickson ... [et al.] -- Prognostic potential of the pre-therapeutic tumor oxygenation status / Peter Vaupel -- Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials / He N. Xu ... [et al.] -- The relationship between vascular oxygen distribution and tissue oxygenation / Alexandru Daşu and Iuliana Toma-Daşu -- Intraoperative measurement of colonic oxygenation during bowel resection / Daya B. Singh ... [et al.] -- Quantifying tumour hypoxia by PET imaging : a theoretical analysis / Iuliana Toma-Daşu, Alexandru Da̧su, and Anders Brahme -- New measurements for assessment of impaired cerebral autoregulation using near-infrared spectroscopy / Dominique De Smet ... [et al.] -- Single shot T1p magnetic resonance imaging of metabolically generated water in vivo / Eric A. Mellon ... [et al.] -- Brain tissue oxygen consumption and supply induced by neural activation : determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex / Kazuto Masamoto ... [et al.] -- Brain oxygen balance under various experimental pathophysiological conditions / Michal Schechter, Judith Sonn, and Avraham Mayevsky -- Ketones suppress brain glucose consumption / Joseph C. LaManna ... [et al.] -- False positives in functional near-infrared topography / Ilias Tachtsidis ... [et al.] -- Relationship between brain tissue haemodynamics, oxygenation, and metabolism in the healthy human adult brain during hyperoxia and hypercapnea / Ilias Tachtsidis ... [et al.] -- Use of a Codman microsensor intracranial pressure probe : effects on near infrared spectroscopy measurements and cerebral hemodynamics in rats / Helga Blockx, Willem Flameng, and Geofrey De Visscher -- Effect of severe hypoxia on prefrontal cortex and muscle oxygenation responses at rest and during exhaustive exercise / Thomas Rupp and Stéphane Perrey.
    Also available: Print – 2009
  • 2010From: Springer
    Duane F. Bruley, Eiji Takahashi, editors.
    Part 1. Physiology and pathophysiology of O2 transport -- Part 2. In vivo measurement of O2 -- Part 3. Exercise and O2 transport -- Part 4. O2 microenvironment in cancer -- Part 5. Clinical aspects of O2 transport.
    Also available: Print – 2010
  • 2011From: Springer
    Joseph C. LaManna ... [et al.], editors.
    Also available: Print – 2011
  • 2012From: Springer
    Martin Wolf ... [et al.], editors.
    Also available: Print – 2012
  • 2013From: Springer
    William J. Welch ... [et al.], editors.
    Also available: Print – 2013
  • 2013From: Springer
    Sabine Van Huffel, Gunnar Naulaers, Alexander Caicedo, Duane F. Bruley, David K. Harrison, editors.
    Part 1. Hypoxia -- Increased kidney metabolism as a pathway to kidney tissue hypoxia and damage: effects of triiodothyronine and dinitrophenol in normoglycemic rats -- Hypoxia-induced cerebral angiogenesis in mouse cortex with two-photon microscopy -- Reduction of cytochrome c oxidase during vasovagal hypoxia-ischaemia in human adult brain: a case study -- Increased HIF-1[alpha] and HIF-2[alpha] accumulation, but decreased microvascular density, in chronic hyperoxia and hypercapnia in the mouse cerebral cortex -- Oxygen delivery: the principal role of the circulation -- Heart rate variability in newborns with hypoxic brain injury -- Part 2. Brain oxygenation -- Simultaneous monitoring of brain and skin oxygenation during haemorrhagic shock in piglets -- Hemispheric differences of motor execution: a near-infrared spectroscopy study -- Acute stress exposure preceding global brain ischemia accelerates decreased doublecortin expression in the rat retrosplenial cortex -- Effects of transcranial direct current stimulation of the motor cortex on prefrontal cortex activation during a neuromuscular fatigue task: an fNIRS study -- Effect of inner speech on arterial CO2, cerebral hemodynamics and oxygenation: a functional NIRS study -- Investigation of frontal lobe activation with fNIRS and systemic changes during video gaming -- Effect of valsalva maneuver-induced hemodynamic changes on brain near-infrared spectroscopy measurements -- Cerebral autoregulation in premature infants -- Brain tissue oxygen saturation increases during sleep in adolescents -- Changes of cerebral oxygen metabolism and hemodynamics during ECPR with hypothermia measured by near infrared spectroscopy: a pilot study -- Part 3. Muscle oxygenation -- Analysis of NIRS-based muscle oxygenation parameters by inclusion of adipose tissue thickness -- Statistical treatment of oxygenation-related data in muscle tissue -- O2 saturation in the intercostal space during moderate and heavy constant-load exercise -- Muscle, prefrontal and motor cortex oxygenation profiles during prolonged fatiguing exercise -- Aging affects spatial distribution of leg muscle oxygen saturation during ramp cycling exercise -- Which is the best indicator of muscle oxygen extraction during exercise using NIRS?: evidence that HHb is not the candidate -- Tissue oxygenation during exercise measured with NIRS: reproducibility and influence of wavelengths -- Using portable NIRS to compare arm and leg muscle oxygenation during roller-skiing in bi-athletes: a case study -- Use of portable NIRS to measure muscle oxygenation and haemodynamics during a repeated sprint running test -- Part 4. Tumor oxygenation -- Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines -- Hypoxia, lactate accumulation and acidosis: siblings or accomplices driving tumor progression and resistance to therapy? -- Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS -- Impact of extracellular acidosis on intracellular pH control and cell signaling in tumor cells -- Tumor oxygenation: an appraisal of past and present concepts, and a look into the future -- In vivo metabolic evaluation of breast tumor mouse xenografts for predicting aggressiveness using the hyperpolarized 13C-NMR technique -- Mapping the redox state of chop-treated non-Hodgkin's lymphoma xenografts in mice -- Maternal bias in mouse radiosensitivity. the role of the mitochondrial PTP -- Interleukin 11 protects bone marrow mitochondria from radiation damage -- Tumor reoxygenation following administration of the EGFR inhibitor, gefitinib, in experimental tumors -- radiation affects the responsiveness of bone marrow to G-CSF -- Application of MOBILE (mapping of oxygen by imaging lipids relaxation enhancement) to study variations in tumor oxygenation -- Primo vascular system and its potential role in cancer metastasis -- Part 5. Cell metabolism -- Pancreaticoduodenectomy using perioperative zymogen protein C to help prevent blood clotting: a trilogy on increased patient safety -- Inhibition of mammalian target of rapamycin induces renal mitochondrial uncoupling in rats -- Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas -- Oxidative metabolism: glucose vs ketones -- Part 6. System modelling -- Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia. simulating pH changes -- Modelling blood flow and metabolism in the piglet brain during hypoxic-ischaemia. simulating brain energetics -- Mathematical modelling of near infrared spectroscopy signals and intracranial pressure in brain injured patients -- Dependence on NIRS source-detector spacing of cytochrome C oxidase response to hypoxia and hypercapnia in the adult brain -- Modeling hemoglobin nitrite reductase activity as a mechanism of hypoxic vasodilation? -- Part 7. Measurement technologies -- Development of a hybrid microwave-optical tissue oxygenation probe to measure thermal response in the deep tissue -- Oxygen sensitive quantum dots for possible nano-scale oxygen imaging in cultured cells -- Boron tracedrug design for neutron dynamic therapeutics for LDL -- New method of analysing NIRS data from prefrontal cortex at rest -- Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors -- Wavelength selection for the improvement of the signal to noise ratio for imaging of haemoglobin oxygenation with RGB reflectometry -- Improving pulse oximetry accuracy by removing motion artifacts from photoplethysmograms using relative sensor motion: a preliminary study -- Measuring the vascular diameter of brain surface and parenchymal arteries in awake mouse -- Simultaneous imaging of cortical blood flow and haemoglobin concentration with LASCA and RGB reflectometry -- Quality evaluation method for rat brain cryofixation based on NADH fluorescence -- Cerebral cortex activation mapping upon electrical muscle stimulation by 32-channel time domain functional near infrared spectroscopy -- NIRS-based neurofeedback learning systems for controlling activity of the prefrontal cortex -- Cortical mapping of 3D optical topography in infants -- Monitoring of hemodynamic change in patients with carotid artery stenosis during the tilt test using wearable near-infrared spectroscopy.
    Also available: Print – 2013
  • 2014From: Springer
    Harold M. Swartz, David K. Harrison, Duane F. Bruley, editors.
    Mitochondrial genetic abnormalities after radiation exposure -- Crediting six discoverers of oxygen -- Hypoxia in tumors: pathogenesis-related classifi cation, characterization of hypoxia subtypes, and associated biological and clinical implications -- Heterogeneity in tissue oxygenation: from physiological variability in normal tissues to pathophysiological chaos in malignant tumours -- Oxygen diffusion: an enzyme-controlled variable parameter -- Role of microvascular shunts in the loss of cerebral blood flow autoregulation -- Impact of hypoxia-related tumor acidosis on cytotoxicity of different chemotherapeutic drugs in vitro and in vivo -- The founding of ISOTT: the Shamattawa of engineering science and medical science -- A tale of two methods: combining near- infrared spectroscopy with MRI for studies of brain oxygenation and metabolism -- Advances in probes and methods for clinical EPR oximetry -- Real-time, in vivo determination of dynamic changes In lung and heart tissue oxygenation using EPR oximetry -- Modulation of hypoxia by magnetic nanoparticle hyperthermia to augment therapeutic index -- Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors -- Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors -- How in vivo EPR measures and images oxygen -- What we learn from in vivo EPR oxygen images -- EPR image based oxygen movies for transient hypoxia -- Repetitive measurements of intrarenal oxygenation in vivo using L band electron paramagnetic resonance -- Quantitative hypoxia imaging for treatment planning of radiotherapy -- A new flavonoid regulates angiogenesis and reactive oxygen species production -- Angiotensin II reduces transport-dependent oxygen consumption but increases transport-independent oxygen consumption in immortalized mouse proximal tubular cells -- Investigation of cerebral autoregulation In the newborn piglet during anaesthesia and surgery -- Influence of the maternal use of labetalol on the neurogenic mechanism for cerebral autoregulation assessed by means of NIRS -- Development of a near infrared multi- wavelength, multi-channel, time-resolved spectrometer for measuring brain tissue haemodynamics and metabolism -- Simulating NIRS and MRS measurements during cerebral hypoxia-ischaemia in piglets using a computational model -- Analysis of slow wave oscillations in cerebral haemodynamics and metabolism following subarachnoid haemorrhage -- Effects of enriched environment on hippocampal neuronal cell death and neurogenesis in rat global ischemia -- Automated image analysis for diameters and branching points of cerebral penetrating arteries and veins captured with two-photon microscopy -- Cerebral hemodynamic change and metabolic alteration in severe hemorrhagic shock -- Physiological mechanism of increase In deoxy-hemoglobin concentration during neuronal activation in patients with cerebral ischemia: a simulation study with the balloon model -- Effect of blood in the cerebrospinal fluid on the accuracy of cerebral oxygenation measured by near infrared spectroscopy -- Vessel specifi c imaging of glucose transfer with fluorescent glucose analogue in anesthetized mouse cortex -- Ischemic pretreatment delays ischemic brain vasospasm Injury in gerbils -- Changes in cerebral blood oxygenation induced by active standing test in children with POTS and NMS -- Optical imaging of brain activation in Gambian infants -- Asymmetrical changes in cerebral blood oxygenation induced by an active standing test in children with postural tachycardia syndrome -- Changes of cerebral tissue oxygen saturation at sleep transitions in adolescents -- Influence of subjective happiness on the prefrontal brain activity: an fNIRS study -- Ginkobiloba extract improves working memory performance in middle-aged women: role of asymmetry of prefrontal cortex activity during a working memory task -- Bayesian prediction of anxiety level in aged people at rest using 2-channel NIRS data from prefrontal cortex -- Short-term hypoxic preconditioning improved survival following cardiac arrest and resuscitation in rats -- Venular valves and retrograde perfusion -- Monitoring of filter patency during carotid artery stenting using near-infrared spectroscopy with high time-resolution -- Use of NIRS to assess effect of training on peripheral muscle oxygenation changes in elite rugby players performing repeated supramaximal cycling tests -- Skeletal muscle deoxygenation responses during treadmill exercise in children -- Development of a hybrid microwave-optical thermoregulation monitor for the muscle -- Evaluation of a textile-based near infrared spectroscopy system in calf muscle oxygenation measurements -- Skin temperature in lower hind limb subjected to distal vein arterialization in rats.
    Also available: Print – 2014
  • 2016From: Springer
    Clare E. Elwell, Terence S. Leung, David K. Harrison, editors.
    This book contains the refereed contributions from the 42nd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 42nd annual meeting, which included sessions on: cellular hypoxia and mitochondria; blood substitutes and oxygen therapeutics; oxygen transport in critical care medicine and disease; muscle oxygenation; multi modal imaging techniques; brain oxygenation and imaging; optical techniques for oxygen measurement; microcirculation; mathematical modelling of oxygen transport; and cancer metabolism.
    Also available: Print – 2016
  • 2016From: Springer
    Qingming Luo, Lin Z. Li, David K. Harrison, Hua Shi, Duane F. Bruley, editors.
    Also available: Print – 2016
  • Scott Fraser Owen.
    Neural circuits throughout the brain are under the continuous influence of neuromodulators which shape network activity in accordance with behavioral context. Oxytocin is a key neuromodulator that has been linked to social memory and maternal behavior in animals, as well as to autism spectrum disorders, trust, emotion recognition and parenting in humans. Here we show that activation of oxytocin receptors sharpens the responses of the hippocampal circuit, increasing the signal of spike transmission through the network while simultaneously suppressing the noise of background spontaneous activity. Both of these actions are mediated through a depolarization of the fast-spiking interneurons. The resulting increase in inhibitory tone serves to silence spontaneous activity in the CA1 pyramidal cells, while a use-dependent depression of the inhibitory synapses permits enhanced feed-forward spike transmission. Furthermore, we show that oxytocin potently modulates spontaneous hippocampal Sharp-Wave Ripple oscillations in a slice preparation. These results elucidate the action of oxytocin in the hippocampus, while simultaneously shedding light on a novel mechanism by which modulation of fast-spiking interneurons can modify hippocampal circuit activity.
  • 2009From: Springer
    Ahmad Wagih Abdel-Halim.
  • 2014From: Springer
    Norbert Weiss, Alexandra Koschak, editors.
    Calcium ions represent Mother Nature's "ion-of-choice" for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.
  • Latest edition, 2014 (7th ed.)From: AccessMedicine
    6th ed., 2010From: AccessMedicine
    McPhee, Stephen J.
    Also available: Print – <2003>
  • 2012From: CRCnetBASE
    edited by Barbara E. Ainsworth and Caroline A. Macera.
    Ch. 1. History of physical activity contributions to public health / Amanda E. Paluch ... [et al.] -- Ch. 2. Physiological adaptations to moderate-intensity aerobic exercise / Arthur S. Leon and Scott Brown -- Ch. 3. The unique influence of sedentary behavior on health / Genevieve N. Healy -- Ch. 4. Physical activity in chronic disease prevention / Jared P. Reis and Bethany Barone Gibbs -- Ch. 5. Physical activity and injury prevention / Kenneth E. Powell -- Ch. 6. Physical activity in treatment of chronic conditions / J. Larry Durstine, Keith Burns, and Ryan Cheek -- Ch. 7. Physical activity in growth and development / Fátima Baptista and Kathleen F. Janz -- Ch. 8. Physical activity and healthy adulthood / Kelley K. Pettee Gabriel and Jennifer L. Gay -- Ch. 9. Physical activity and healthy aging / David M. Buchner -- Ch. 10. Physical activity and obesity / Catrine Tudor-Locke -- Ch. 11. Physical activity measurement / Stephen D. Herrmann -- Ch. 12. National guidelines for physical activity / Richard P. Troiano and David M. Buchner -- Ch. 13. Surveillance of physical activity / Janet E. Fulton and Susan A. Carlson -- Ch. 14. Physical activity promotion in underserved communities / Deborah Parra-Medina and Zenong Yin -- Ch. 15. Built environmental supports for walking / Paula Hooper ... [et al.] -- Ch. 16. Physical activity promotion in worksites / Joan Dorn and Cassandra Hoebbel -- Ch. 17. Promotion of physical activity in schools / Dianne Stanton Ward and Christopher Ford -- Ch. 18. Policy for physical activity promotion / Kelly R. Evenson and Semra A. Aytur
  • 2015From: Springer
    edited by Kazuyuki Kanosue, Satomi Oshima, Zhen-Bo Cao, Koichiro Oka.
    Preface -- Part I: Current Status of Physical Activity and Sedentary Behavior Research -- Physical Activity Levels and Physical Activity Recommendations in Japan -- Population Strategy for Physical Activity Promotion in the Community -- Promotion of Strength Training -- Does Newspaper Coverage Promote Cancer Prevention? -- Health Impact of Light -- Evaluation of Physical Activity and Sedentary Behavior -- Sedentary Behaviour -- Prevalence, Trends, and Correlates of Sedentary Behavior -- Part II: Effects of Physical Activity, Exercise, and Fitness on the Human Organism -- Responses of the Autonomic Nervous and Endocrine Systems to Exercise -- Exercise Modes and Vascular Functions -- Exercise, Appetite Control, and Body Weight Regulation -- Exercise and Food Intake -- Role of Physical Exercise on Postprandial Blood Glucose Responses to Low-Carbohydrate/High-Fat Diet Intake -- Posttranslational Modification of Proteins -- Relationship of Cardiorespiratory Fitness and Obesity Genes to Metabolic Syndrome in Adult Japanese Men -- Mechanisms Underlying the Suppression of Inflammatory Responses in Peritoneal Macrophages of Middle-aged Mice -- Effects of b2-Agonist Administration on Bacterial Phagocytosis by Splenic Macrophages in Mice -- Functional Roles of b2-Adrenergic Receptors in Skeletal Muscle Hypertrophy and Atrophy -- Part III: Physical Activity, Exercise, Nutrition, Aging, and Health -- The Role of Exercise and Nutrition in Lifestyle-related Disease -- Vasopressin V1a receptor gene and voluntary exercise in humans and mice -- The Role of Physical Activity in the Prevention of Atherosclerosis -- Association Between Exercise and Diet on Maintaining Bone Health in Postmenopausal Women and Female Athletes -- Pain Management Among Elderly People with Knee Pain -- Effective Exercise Programs Among Frail Elderly People -- Rowing -- Influence of Aging on Postural Control in Terms of Sensory Movements.
  • 2012From: Thieme
    Roger TannerThies.
    "Physiology--An Illustrated Review helps you master important physiologic facts and concepts and teaches you how to apply that knowledge successfully on course exams and in daily practice. This indispensable review book includes 200 spectacular, full-color illustrations depicting cardiologic, cellular, and renal function. It also includes all the regular series features, including 400 print and online review questions and explanatory answers"--Provided by publisher.
  • [edited by] Patricia J. Metting, James F. Kleshinski.
    Status: Not Checked OutLane Catalog Record
    High-Yield Facts -- General Principles: Cellular Physiology -- General Principles: Multisystem Processes -- Physiology of the Hematopoietic and Lymphoreticular Systems -- Neurophysiology -- Musculoskeletal Physiology -- Respiratory Physiology -- Cardiovascular Physiology -- Gastrointestinal Physiology -- Renal and Urinary Physiology -- Reproductive Physiology -- Endocrine Physiology.
  • [edited by] Patricia J. Metting.
    Status: Not Checked OutLane Catalog Record
  • 2014From: McGraw-Hill eBook Library
    [edited by] Patricia J. Metting, PhD.
    High-yield facts -- General principles: cellular physiology -- General principles: multisystem processes -- Physiology of the hematopoeitic and lymphoreticular systems -- Neurophysiology -- Musculoskeletal physiology -- Respiratory physiology -- Cardiovascular physiology -- Gastrointestinal physiology -- Renal and urinary physiology -- Reproductive physiology -- Endocrine physiology.
  • 2013From: Springer
    Jean-Philippe Bastard, Bruno Fève, editors.
    The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
  • Andrew W. Wood ; with contributions by Anthony Bartel ... [et al.].
    Status: Not Checked OutLane Catalog Record
    "Preface The aim of this book is to show that many aspects of human physiology lend themselves to numerical analysis. Many ways of monitoring physiological function also rely on an understanding of physics and engineering to appreciate fully how they operate. The book arises out of an undergraduate course in medical biophysics and a postgraduate course in biomedical instrumentation the authors were involved in for many years. Although the emphasis is on numerical analysis only, a basic knowledge of mathematics is assumed and every effort is made to supplement mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes involved. Most of the chapters have a range of numerical tutorial problems with, in most cases, worked solutions. These are based on examination questions at the middle and senior undergraduate level. For some of the material, the computational package MATLABʼ offers a convenient way to gain insight into some of the more advanced mathematical analysis of physiological or of clinical monitoring systems. Suitable MATLAB code is provided where this might aid understanding. I acknowledge the help of colleagues in the preparation of this book. Particular chapters have been authored as follows: Anthony Bartel, Per Line, Peter Cadusch, Joseph Ciorciari, David and Sheila Crewther, John Patterson , Mark Schier, Bruce Thompson. In addition, others have been associated with teaching the course over many years. These include: Peter Alabaster, David Liley, Ric Roberts and David Simpson"--Provided by publisher.
  • 2012From: ScienceDirect
    2012From: ClinicalKey
    editor-in-chief, Leonard R. Johnson ; associate editors, Fayez K. Ghishan ... [et al.].
    The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations.
  • [1] 1901-1921. -- [2] 1922-1941. -- [3] 1942-1962. -- [4] 1963-1970.
    Also available: Print – v. 1-3, 1964-67.(Covers 1901-1962)
  • 2018From: ClinicalKey
    Linda S. Costanzo.
    Cellular physiology -- Autonomic nervous system -- Neurophysiology -- Cardiovascular physiology -- Respiratory physiology -- Renal physiology -- Acid-base physiology -- Gastrointestinal physiology -- Endocrine physiology -- Reproductive physiology.
  • Linda S. Costanzo.
    Status: Not Checked OutLane Catalog Record
    Cell physiology -- Neurophysiology -- Cardiovascular physiology -- Respiratory physiology -- Renal and acid-base physiology -- Gastrointestinal physiology -- Endocrine physiology.
  • Bell, George Howard.
    Status: Not Checked OutLane Catalog Record
  • 2016From: ClinicalKey
    John E. Hall, PhD, Arthur C. Guyton Professor and Chair, Department of Physiology and Biophysics, Director of the Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi..
  • 2012From: Cambridge
    Anne Stiles.
    "In the 1860s and 1870s, leading neurologists used animal experimentation to establish that discrete sections of the brain regulate specific mental and physical functions. These discoveries had immediate medical benefits: David Ferrier's detailed cortical maps, for example, saved lives by helping surgeons locate brain tumors and haemorrhages without first opening up the skull. These experiments both incited controversy and stimulated creative thought, because they challenged the possibility of an extra-corporeal soul. This book examines the cultural impact of neurological experiments on late Victorian Gothic romances by Robert Louis Stevenson, Bram Stoker, H. G. Wells and others. Novels like Dracula and Jekyll and Hyde expressed the deep-seated fears and visionary possibilities suggested by cerebral localization research and offered a corrective to the linearity and objectivity of late Victorian neurology"--Provided by publisher.
  • 2014From: Springer
    edited by Liron Pantanowitz, Anil V. Parwani.
    Introduction to informatics / Liron Pantanowitz -- Basic computing / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Networking / Muhammad A. Syed, Anil V. Parwani, and Liron Pantanowitz -- Databases / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Coding / Seung L. Park, Jacqueline Cuda, and Liron Pantanowitz -- Laboratory information systems / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Laboratory information system operations and regulations / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Reporting / Liron Pantanowitz -- Quality management / Liron Pantanowitz, Luke T. Wiehagen, and R. Marshall Austin -- Barcoding / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Informatics projects / Liron Pantanowitz -- Lean Six Sigman / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Electronic medical records / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Digital imaging / Milon Amin, Anil V. Parwani, and Liron Pantanowitz -- Automated pap tests / Liron Pantanowitz -- Telecytology / Sara E. Monaco and Liron Pantanowitz -- Cytology online / Walid E. Khalbuss -- Bioinformatics / Somak Roy, Liron Pantanowitz, and Anil V. Parwani -- Research informatics / Somak Roy, Liron Pantanowitz, Anil V. Parwani.
  • 2013From: ClinicalKey
    [edited by] Jason L. Hornick.
    Introduction : tumor classification and biologic potential / Jason L. Hornick -- Grading and reporting of soft tissue sarcomas / Jason L. Hornick -- Spindle cell tumors / Adrian Marino-Enriquez, Louis Guillou, and Jason L. Hornick -- Pediatric spindle cell tumors / Cheryl M. Coffin -- Tumors with myxoid stroma / Alessandra F. Nascimento and Jason L. Hornick -- Epithelioid and epithelial-like tumors / Essia Saiji, Louis Guillou, and Jason L. Hornick -- Pleomorphic sarcomas / J. Frans Graadt Van Roggen and Pancras C.W. Hogendoorn -- Round cell tumors / Enrique De Alava -- Biphasic tumors and tumors with mixed patterns / Alessandra F. Nascimento and Jason L. Hornick -- Tumors associated with prominent inflammatory cells / Jason L. Hornick -- Giant cell-rich tumors / Bernadette Liegl-Atzwanger and Jason L. Hornick -- Adipocytic tumors / Licia Laurino and Angelo Paolo Dei Tos -- Vascular tumors / Briana C. Gleason and Jason L. Hornick -- Cartilaginous and osseous soft tissue tumors / Andre M. Oliveira -- Cutaneous mesenchymal tumors / Thomas Brenn and Jason L. Hornick -- Mesenchymal tumors of the gastrointestinal tract / Brian P. Rubin and Jason L. Hornick -- Lower genital soft tissue tumors / Marisa R. Nucci -- Applications of molecular testing to differential diagnosis / Alexander J. Lazar.
  • 2012From: ClinicalKey
    editors, Mark D. Miller, Timothy G. Sanders.
    Take the mystery out of MRI interpretation and its relationship to arthroscopy with this book by Drs. Mark D. Miller and Timothy G. Sanders. Abundantly illustrated with MR, arthroscopic, and anatomical images, this new title offers both orthopaedists and radiologists a correlated, systematic approach to diagnosis, helping you achieve accurate evaluations and ensuring that all clinically relevant structures are adequately assessed. An accompanying case-based DVD illustrates pathology and repair, with side-by-side comparisons of MRI and arthroscopic findings in the same patient. Improve diagnostic accuracy, surgical planning/decision making, and patient outcomes by seeing how to correlate MRI and arthroscopic findings. Gain an enhanced appreciation of the sensitivity and specificity of MRI as a tool in musculoskeletal diagnosis. Enhance your diagnostic skills by reviewing illustrative case studies for each major joint, examining specific MRI and arthroscopic findings and considering the range of possible diagnoses. View side-by-side comparisons of MRI and arthroscopic footage in the same patient - augmented by line illustrations that orient the arthroscopic views - by watching the videos on the bound-in DVD. Take the mystery out of MRI interpretation to assess more confidently.
  • 2016From: Springer
    Alain Dabdoub, Bernd Fritzsch, Arthur N. Popper and Richard R. Fay, editors.
    1. Connecting the inner ear to the central auditory system: molecular development and characteristics of the primary auditory neurons and their network -- 2. Early development of the spiral ganglion -- 3. Neurotrophic factor function during ear development: expression changes define critical phases for neuronal viability -- 4. The electrophysiological signature of spiral ganglion neurons -- 5. The ribbon synapse between type I spiral ganglion neurons and inner hair cells -- 6. Central projections of spiral ganglion neurons -- 7. The spiral ganglion in an out-of-body experience: a brief history of in vitro studies of the spiral ganglion -- 8. Loss, degeneration, and preservation fo the spiral ganglion neurons and their processes -- 9. Stem cells for the replacement of auditory neurons.
  • Gerard J. Tortora, Bryan H. Derrickson.
    Status: Not Checked OutLane Catalog Record
  • 2002From: ScienceDirect
    edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.
    v. 1.-- Part. I. Basic principles -- v. 2.-- Part. II. Molecular mechanisims of metabolic bone diseases -- Part. III. Pharmacological mechanisms of therapeutics -- Part. IV. Methods in bone research.
  • 2010From: ScienceDirect
    2010From: ClinicalKey
    edited by Marianne J. Legato ; section editors, William Byne ... [et al.].
    Chapter 1. The Effects of Gender in Neonatal Medicine / Tove S. Rosen, David Bateman -- Chapter 2. Sexual Development, Growth, and Puberty in Children / Gaya S. Aranoff, Jennifer J. Bell -- Chapter 3. Gender Differences in Pediatric Pulmonary Disease / Beverley J. Sheares -- Chapter 4. Gender-Specific Aspects of Pediatric Hematology and Oncology / James H. Garvin Jr. -- Chapter 5. Gender Differences in Neurological Conditions of Children / David M. Kaufman -- Chapter 6. Gender and Sports: Past, Present, and Future / Jordan D. Metzl -- Chapter 7. Gender Differences in the Functional Organization of the Brain / Ruben C. Gur, Tamara Bockow, Raquel E. Gur -- Chapter 8. Sexual Differentiation of Brain Structure and Function / Margaret M. McCarthy -- Chapter 9. The Sexed and Gendered Brain / William Byne -- Chapter 10. Age and Gender-Specific Patterns of Neurologic Illness / Joan Amatniek, Karin Sorra, Lauren Frey, W. Allen Hauser -- Chapter 11. Gender Differences in Stroke / Rebecca F. Gottesman, Argye E. Hillis -- Chapter 12. Gender Differences in Disorders that Present to Psychiatry / Mary V. Seeman -- Chapter 13. Hormone Replacement Therapy and Cognitive Function / Mary Sano, Diane Jacobs, Katya Gaynor -- Chapter 14. Gender and the Heart: Sex-Specific Differences in the Normal Myocardial Anatomy and Physiology / Marianne J. Legato, Jaswinder K. Leghe -- Chapter 15. Gender-Specific Aspects of Selected Coronary Heart Disease Risk Factors: A Summary of the Epidemiologic Evidence / Shari S. Bassuk, JoAnn E. Manson -- Chapter 16. Dyslipidemia Management in Women and Men: Exploring Potential Gender Differences / Kavita Sharma, Christian D. Nagy, Roger S. Blumenthal -- Chapter 17. Gender Differences in the Role of Stress and Emotion in Cardiovascular Function and Disease / David E. Anderson, Margaret A. Chesney -- Chapter 18. The Role of Sex and Gender in Cardiothoracic Surgery / Sandhya K. Balaram, Justin D. Blasberg -- Chapter 19. Gender Differences in Asthma / Robert H. Lim, Lester Kobzik -- Chapter 20. Gender Issues in Venous Thromboembolism / Susan Murin, Kathryn Bilello, Lisa Moores, Aaron Holley -- Chapter 21. Sleep in Women: Gender Differences in Health and Disease / Shirin Shafazand -- Chapter 22. Are Women More Susceptible to Chronic Obstructive Pulmonary Disease? / Kenneth R. Chapman -- Chapter 23. The Gender-Specific Aspects of Lung Cancer / Rebecca L. Toonkel, Charles A. Powell -- Chapter 24. Gender-Specific Considerations in Pulmonary Hypertension / Deborah Shure -- Chapter 25. Sex and Gender Differences in Pulmonary Manifestations of Autoimmune Disease / Muddassir Aliniazee, Marilyn K. Glassberg -- Chapter 26. Benign Metastasizing Leiomyoma and Lymphangioleiomyomatosis: Lung Diseases of Women / Muddassir Aliniazee, Marilyn K. Glassberg -- Chapter 27. Gender Differences in Susceptibility, Outcomes, and Pathophysiology of Sepsis / Kristy A. Bauman, MeiLan K. Han -- Chapter 28. Inflammatory Bowel Disease in Women / Melissa Munsell, Marc Sonenshine, Mary L. Harris -- Chapter 29. Disorders of Defecation in Women / Susan L. Gearhart -- Chapter 30. Idiopathic Gastroparesis: Gender Aspects / Henry P. Parkman -- Chapter 31. Liver Disease in Women / Karen Krok, Ayman Koteish -- Chapter 32. Gender Differences in Irritable Bowel Syndrome / Octavia Pickett-Blakely, Linda A. Lee, Gerald Mullin -- Chapter 33. Contraception / Karen Feisullin, Carolyn Westhoff -- Chapter 34. Infertility: The Male / Howard H. Kim, Peter N. Schlegel, Marc Goldstein -- Chapter 35. Infertility and In Vitro Fertilization / Elizabeth Barbieri, Sonya Kashyap, Pak H. Chung -- Chapter 36. Female Sexual Health / Barbara D. Bartlik, Julie A. Kolzet, Nazia Ahmad, Tahmina Parveen, Sarah Alvi -- Chapter 37. Male Sexual Dysfunction / Serkan Deveci, John P. Mulhall -- Chapter 38. Pelvic Pain: Urogenital Female Disorders / Andrew T. Goldstein, Lara J. Burrows -- Chapter 39. Lower Urogenital Tract Dysfunction in Men and Women / Doreen E. Chung, Alexis E. Te, Renuka Tyagi -- Chapter 40. Aging and the Lower Urogenital System / Catherine E. DuBeau -- Chapter 41. Menopause / Gloria Bachmann, Nora J. Doty -- Chapter 42. The Differences between Male and Female Breast Cancer / Coral Omene, Amy Tiersten -- Chapter 43. Difference in Germ Cell Tumors of the Reproductive Tract in Men and Women / Nicole LaNatra, Amy Tiersten -- Chapter 44. Gender Differences in Hereditary Cancer Syndromes: Risks, Management, and Testing for Inherited Predisposition to Cancer / Wendy K. Chung -- Chapter 45. Gender Differences in Emerging Infectious Diseases / Sharon Lewin -- Chapter 46. Sexually Transmitted Infections in Men and Women / Anne M. Rompalo, Khalil G. Ghanem -- Chapter 47. Infections in Pregnancy / Emilia Mia Sordillo, Bruce Polsky -- Chapter 48. Adult Immunization in Women and Men / Sally L. Hodder, Debra Chew, Shobha Swaminathan -- Chapter 49. Gender Differences in Autoimmune Diseases: Immune Mechanisms and Clinical Applications / Nabih I. Abdou, Virginia Rider -- Chapter 50. Hormones and Cytokines: Gender-Specific Effects / Maurizio Cutolo -- Chapter 51. Prolactin and Autoimmunity / Sara E. Walker -- Chapter 52. Sex Hormones and Immune Function / Robert G. Lahita -- Chapter 53. Pregnancy and Autoimmune Rheumatic Disease / Carl A. Laskin, Christine A. Clark, Karen A. Spitzer -- Chapter 54. Oral Contraceptives and Autoimmune Diseases / Taraneh Mehrani, Michelle Petri -- Chapter 55. Gender-Specific Issues in Organ Transplantation / Hilary Sanfey Chapter 56. Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women / Sherita Hill Golden -- Chapter 57. Thyroid Disorders and Pregnancy / Matthew Kim -- Chapter 58. Sexual Function and Dysfunction in Men and Women / Karen Elizabeth Boyle, Arthur L. Burnett -- Chapter 59. Osteoporosis in Men and Women / Kendall F. Moseley, Suzanne M. Jan de Beur -- Chapter 60. Testosterone Replacement Therapy in Men and Women / Diala El-Maouche, Adrian Dobs.
  • 2013From: Springer
    Wen-Quan Zou, Pierluigi Gambetti, editors.
    Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
  • 2013From: Springer
    edited by Wen-Quan Zou and Pierluigi Gambetti.
    Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
  • 2010From: ClinicalKey
    Robert G. Carroll.
    Section 1. Nerves and muscles -- section 2. Cardiovascular physiology -- section 3. Renal water and electrolyte balance -- section 4. Hematology -- section 5. Respiration -- section 6. Neurology -- section 7. Gastroenterology -- section 8. Metabolism -- section 9. Endocrinology -- section 10. Reproduction.
  • Hammond, John.
    Status: Not Checked OutLane Catalog Record
  • Mindy H. Chang.
    The visual system has a limited capacity for capturing and processing the richness and intricate detail of the surrounding environment. Visual information that arrives in the retina is converted from relative light intensities to patterns of excitation and then transmitted to a hierarchy of visual areas, which process and combine increasingly complex features of the visual signal to form a visual percept. At each stage, the amount of task or stimulus-related information a neuron can encode depends on the separability of its responses to different conditions. Using electrophysiological recordings of extracellular spiking activity from single neurons in awake behaving monkeys, we explored ways to quantify information in neuronal firing rates in order to address specific questions about sensory and cognitive signals in visual cortex and frontal cortex during different behavioral contexts. In the first study, we addressed a question of latency differences in the visual pathways that process color using a passive fixation task. Color processing occurs generally along two separate chromatic pathways, and previous work has indicated that information from the two pathways arrive with a relative lag in primary visual cortex. However, to form a perception of color, these two pathways must converge at some stage of visual processing. We used information theory to examine the timecourse of chromatic information in neurons further up the visual hierarchy in area V4, which has been implicated as an area with an important role in color processing. We found that on average, information specific to each pathway arrived simultaneously in V4, suggesting that color signals from the different pathways converge at some point within or before V4 in the visual hierarchy. In order to select behaviorally relevant information from the large amount of visual information available, shifting the focus of gaze (via saccadic eye movements) and directing attention provide ways to allocate processing resources to selected locations in visual space. Studies have shown that perceptual enhancements at behaviorally selected spatial locations are accompanied by enhanced processing in visual cortex. The mechanisms by which neurons in the brain control the selection of sensory signals remain unclear. Previous works suggest that the control of attention and eye movements, as well as the modulation of sensory representations, originate in a distributed network that includes the frontal eye field (FEF) in frontal cortex. We studied responses of single neurons recorded separately in area V4 and the FEF of monkeys engaged in different visuospatial selection tasks. In addition to firing rate responses, we examined the trial-to-trial response variability, which has been suggested to reflect behavioral state. During natural vision, the eyes make frequent movements to selected targets. To better understand how these gaze shifts influence visual processing, we examined selective visual processing in area V4 during saccade preparation. We found that V4 neurons show transiently enhanced stimulus discrimination at the saccade target. This enhancement is due in part to changes in response magnitude, but may also be facilitated by reduced variability (increased reliability) of sensory representations. The similarity to effects of covert attention and experimental manipulations of FEF activity provides further evidence that the mechanisms driving visual modulation during saccade preparation and covert spatial attention rely on common neural resources. To explore signals that likely modulate visual responses through feedback connections, we examined the role of FEF neurons in the maintenance and selection of spatial information. In a task that required remembering and directing spatial attention to a cued location while withholding eye movements, neurons in the FEF exhibited spatially selective persistent activity, which continuously tracked the location of the cue. Moreover, this maintenance of spatial information correlated with successful deployment of attention. Despite robust visual and cognitive firing rate modulations that predicted behavioral performance on the task, declines in response variability appeared to be most effectively driven by visual stimulation, rather than spatial working memory or attention. This indicates that, at least in the FEF, behavioral engagement alone is not sufficient to drive changes in variability. Instead, changes in response variability may reflect shifts in the balance between feedforward and recurrent sources of excitatory drive.
  • Erin Elizabeth Butler.
    The ability to reach, grasp, transport, and release objects is central to activities of daily living, such as feeding and grooming. However, children with cerebral palsy (CP) often have difficulty with these tasks, limiting their independence. While it is challenging to characterize and quantify specific upper limb movement disorders in CP, it is essential for identifying the underlying neural correlates and etiology, assessing movement disorder subtypes, i.e. spasticity, dystonia, and ataxia, which affect treatment selection, and measuring treatment outcomes. Current methods for measuring upper limb motion deficits are based predominantly on subjective, observational assessments. Thus, we have proposed three-dimensional motion analysis of the upper limbs during a Reach & Grasp Cycle to address the need for a standardized protocol for analysis of upper limb motion. The Reach & Grasp Cycle is a sequence of tasks that incorporates all major joints of the upper limb and simulates a functional task that is feasible yet challenging for individuals with CP. Using a biomechanical model of the trunk and upper limbs, we calculated three-dimensional joint kinematics and temporal-spatial parameters for 30 typically developing (TD) children and 25 children with CP and upper limb involvement, ages 5-18 years, using an optoelectric motion analysis system. Consistent normative data and clinically significant differences in joint motions and temporal-spatial parameters between the CP and TD children suggest the Reach & Grasp Cycle is a repeatable protocol for objective and quantitative clinical evaluation of functional upper limb motor performance. Next, we derived a single score of upper limb pathology from upper limb kinematics called the Pediatric Upper Limb Motion Index (PULMI). The root-mean-square difference was calculated between the data of each child with CP and the average from the TD population for eight kinematic variables over the Reach & Grasp Cycle. The raw value was then scaled such that a PULMI score [greater than or equal to] 100 indicated the absence of upper limb pathology, and every 10 points below 100 corresponded to one standard deviation away from the TD PULMI mean. The PULMI was significantly different between the TD children and children with CP (Wilcoxon Z=-5.06, p< .0001), and between children with spastic CP and dyskinetic CP (Z=-2.47, p< .0135). There was a strong negative correlation between the PULMI and the standard Manual Ability Classification System for all children with CP (Spearman's rho=-.78, p< .0001), indicating good validity of the PULMI. In addition, four key temporal-spatial parameters (movement time, index of curvature during reach, ratio of the peak velocity of the transport and reach phases of the Reach & Grasp Cycle, and total number of movement units) revealed differences in movement patterns between CP and TD children. Furthermore, a multi-variable logistic regression of these temporal-spatial parameters was derived which correctly predicted 19 of 22, or 86%, of movement disorder sub-types (spastic versus dyskinetic CP). This research describes a pediatric upper limb motion index (PULMI) for children with cerebral palsy (CP) that provides information regarding the quality of upper limb motion during a functional sequence of tasks. The PULMI, calculated from upper limb kinematics, and key temporal-spatial parameters of the Reach & Grasp Cycle offer a quantitative approach to analyzing the quality of upper limb function in children with CP and identifying specific types of movement deficits. It is suggested for use in both research and clinical applications.
  • Joseph V. Tranquillo.
    Neural anatomy -- Passive membranes -- Active membranes -- Propagation -- Neural branches -- Synapses -- Networks of neurons -- Extracellular recording and stimulation -- The neural code -- Applications.
  • 2013From: Springer
    Jonathan Mamou, Michael L. Oelze, editors.
    Due to parallel advances in signal processing and computer hardware in the last 15 years, quantitative ultrasound techniques have reached maturity, allowing for the construction of quantitative maps or images of soft tissues. This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: - Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.; - Envelope statistics analysis as a means of quantifying and imaging tissue properties; - Ultrasound elastography for quantifying elastic properties of tissues (several clinical ultrasound scanners now display elastography images); - Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution (desktop size scanners are now available); and - Ultrasound computer tomography for breast cancer imaging (new ultrasound tomography systems have been developed and are currently under evaluation clinically).
  • 1888-From: Google Books
    Hare, H. A.; Raymond, Joseph H.; Hare, H. A.
    Also available: Print – 1888.
  • 2012From: Springer
    edited by William S. Spielman, Narayanan Parameswaran.
    Introduction to RAMPs / Narayanan Parameswaran and William S. Spielman -- RAMPs and CGRP receptors / James Barwell ... [et al.] -- Regulation of GPCR trafficking by RAMPs / Jennifer M. Bomberger, Narayanan Parameswaran, and William S. Spielman -- Regulation of calcium sensing receptor trafficking by RAMPs / Tristan Bouschet, Støphane Martin, and Jeremy M. Henley -- Understanding RAMPs through genetically engineered mouse models / Mahita Kadmiel, Kimberly L. Fritz, and Kathleen M. Caron -- RAMPs as drug targets / Patrick M. Sexton ... [et al.] -- RAMP like proteins : RTP and reep family of proteins / Joel Mainland and Hiroaki Matsunami -- Regulation of RAMP expression in diseases / Asha Jacob, Rongqian Wu, and Ping Wang -- Perspectives on some recent studies on RAMPs / Narayanan Parameswaran and William S. Spielman.
    Also available: Print – 2012
  • Wang Rui.
    How the human brain processes phonemes has been a subject of interest for linguists and neuroscientists for a long time. Electroencephalography (EEG) offers a promising approach to observe neural activities of phoneme processing in the brain, thanks to its high temporal resolution, low cost and noninvasiveness. The studies on Mismatch Negativity (MMN) effects in EEG activities in the 1990s suggested the existence of a language-specific central phoneme representation in the brain. Recent findings using magnetoencephalograph (MEG) also suggested that the brain encodes the complex acoustic-phonetic information of speech into the representations of phonological features before the lexical information is retrieved. However, very little success has yet been reported in classifying the brain activities associated with phoneme processing. In my work, I proposed a classification framework which incorporates Principal Components Analysis (PCA), cross-validation and support vector machine (SVM) methods. The initial classification rates were not very good. Progress was made by using bootstrap aggregation (Bagging) scheme and introducing phase calculations. To calculate phase, I computed the Discrete Fourier Transform (DFT) of the original time-domain signal and kept the angles of the finite sample of frequencies. The resulting EEG spectral representation contains only the phase and frequency information and ignores the amplitudes. Using this method, the accurate rate of classifying averaged test samples of eight consonants improved from 41% to 51%. Furthermore, the qualitative analysis of the similarities between the EEG representations, derived from the confusion matrices, illustrates the invariance of brain and perceptual representation of phonemes. For brain and perceptual representation of consonants, voicing is the most distinguishable feature among voicing, continuant and place of articulation. And the feature vowel-height is more robust than vowel-backness in both brain and perceptual representation of vowels. By extending and further refining these methods, it is likely significant classification of other phonemes and features can be made.
  • David Yoonsuk Oh.
    T cell development involves stereotyped movements of developing thymocytes through specific stromal microenvironments in thymus, with immature double-negative (DN, CD4-CD8-) and double-positive (DP, CD4+CD8+) thymocytes found in cortex, and mature single-positive (SP, CD4+CD8- or CD4-CD8+) thymocytes in medulla. Critical events occur in each of these locations, notably positive selection, which leads to survival and maturation of DPs and occurs in cortex, and negative selection, which leads to elimination of autoreactive thymocytes and can occur in cortex or medulla depending on the type of antigen. Several key questions remain about the mechanisms underlying these developmental transitions. How are thymocytes properly localized to cortex and medulla? Is there further specialization of stroma within these regions for supporting thymocyte migration or signaling? How do Ca2+ signals, which are critical for both positive and negative selection, differ between these two developmental pathways? In this thesis, we utilize thymic slices, which preserve native stromal architecture and support thymocyte development, to address these questions. Two-photon microscopy of fluorescently labeled thymocytes within slices allows us to non-invasively image the migration, localization, and signaling of single thymocytes in real time, providing a better understanding of how these behaviors are regulated during development and also as a function of location in tissue. In Chapter 2, we address the question of how developing thymocytes are localized to their proper tissue locations in thymus. When layered on the cut surface of slices, purified stages of thymocytes localize to their proper thymic environments, with immature DNs and DPs restricted to cortex, and SPs concentrating in medulla. Remarkably, we find evidence for two distinct mechanisms controlling proper localization of immature versus mature thymocytes. Pre-selection DPs are strictly localized to cortex by their inability to migrate on medullary substrates. SPs localize to medulla via CCR7-dependent chemotaxis, which is directly demonstrated, as well as a novel GPCR-mediated signaling module permitting SP migration on medullary substrates. In Chapter 3, we examine differences in Ca2+ signaling between positive versus negative selection, as well as between distinct locations in thymus, and clarify the role of Ca2+ in controlling motility during negative selection. We find larger Ca2+ signals during early stages of negative selection relative to positive selection, and stronger signaling in response to selecting antigens in the inner cortex near medulla. Sustained Ca2+ signals during negative selection are largely not required for stopping cells, but do contribute to prolonging motile arrest of a proportion of the thymocyte population. Overall these results point to several key events during the transition from cortical DPs to medullary SPs that may enhance the efficiency of selection. As DPs pass through a specialized inner cortical environment, they may become more responsive to peptide ligands leading to positive and negative selection. Stronger Ca2+ signals during negative compared to positive selection in DPs and SPs may help to commit thymocytes to death over maturation. Finally, the ability to migrate in medulla, which thymocytes acquire post-positive selection, may represent an important developmental switch confining pre-selection cells to cortex for further testing against selecting antigens, while permitting post-positive selection thymocytes to undergo an additional layer of testing against tissue-specific antigens, followed by maturation and exit.
  • Andrea Elise Hartsock.
    Throughout development cells must go through numerous changes in cell-cell adhesiveness. Within an epithelial layer, cell-cell contacts form and maintenance junctional complexes such as Adherens Junctions, Tight Junctions, and Desmosomes. The Adherens junction (AJ) and Tight junction (TJ) provide important adhesive contacts between neighboring epithelial cells. Although these junctions comprise different proteins, there are similarities in the roles of specialized transmembrane proteins in forming extracellular adhesive contacts between cells, and intracellular links to the actin cytoskeleton and signaling pathways including the regulation of gene transcription. The Adherens junction performs multiple functions including initiation and stabilization of cell--cell adhesion, regulation of the actin cytoskeleton, intracellular signaling and transcriptional regulation. The core of the Adherens junction includes interactions among transmembrane glycoproteins of the classical cadherin superfamily, such as E-cadherin, and the catenin family members including p120-catenin, [Beta]-catenin, and [Alpha]-catenin. Together, these proteins control the formation, maintenance and function of adherens junctions. Tight junctions have been proposed to have two mutually exclusive functions: a fence function which prevents the mixing of membrane proteins between the apical and basolateral membranes; and a gate function which controls the paracellular passage of ions and solutes in-between cells. Tight junctions contain two types of transmembrane proteins, occludins and claudins, which confer these functions, and associated cytoplasmic proteins that may link tight junctions to the actin-cytoskeleton and the adherens junction. Adherens Junction mediated cell--cell adhesion is highly dynamic enabling the reorganization and dispersal of cells, for example, during epithelial-to-mesenchymal transition in normal development and carcinogenesis. p120-Catenin binding to, and Hakai (an E3 ubiquitin ligase)-mediated ubiquitination of the juxtamembrane domain (JMD) of E-cadherin are thought to be involved in regulating E-cadherin internalization and degradation. However, the relationship between these two pathways is not known. The aim of my project was to determine if p120-catenin/E-cadherin and Hakai dependent ubiquitination of E-cadherin are mechanistically linked. We targeted the E-cadherin JMD to mitochondria (WT-JMD) to isolate this domain from the plasma membrane and internalization, and to examine protein modifications and degradation. WT-JMD was targeted to mitochondria, but it did not accumulate there except when proteasome activity was inhibited. We found that WT-JMD was ubiquitinated, and arginine substitution of lysines at position 5 (K5R) and 83 (K83R) resulted in the stable accumulation of mutant JMD at mitochondria. p120-Catenin did not localize, or bind to WT-JMD even upon proteasome inhibition, whereas the K5,83R JMD mutant bound p120-catenin and localized it to mitochondria. Mutation of the p120-catenin binding site in combination with these lysine mutations inhibited p120-catenin bind-ing, but did not decrease JMD stability or its accumulation at mitochondria. Further-more, over-expression of Hakai resulted in inhibition of p120-catenin binding to WT-JMD. Thus, increased stability of JMD lysine mutants was due to inhibition of ubiquitination and not to p120-catenin binding. Finally, mutation of these critical lysines in full length E-cadherin had the same effects on protein stability as mitochondria-targeted E-cadherin JMD. Our results indicate that ubiquitination of the JMD inhibits p120-catenin binding, and targets E-cadherin for degradation via the proteasome. Further work needs to be done to test our hypothesis that p120-catenin stabilizes E-cadherin by masking ubiquitination sites within E-cadherin-JMD.
  • 2007From: Springer
    edited by Setsuro Ebashi and Iwao Ohtsuki.
    Also available: Print – 2007
  • 2014From: CRCnetBASE
    editors, Joseph T. Ciccolo and William J. Kraemer.
    "Resistance training is a form of strength training in which each effort is performed against a specific, opposing force generated by resistance. Increasing evidence-based research highlights the importance of not only aerobic exercise, but resistance training in the prevention, management, and treatment of many chronic conditions. This book presents research on the benefits of resistance training for chronic diseases/disorders. Chapters cover resistance training to treat cardiovascular disease, metabolic diseases, cancer, orthopedic diseases, and neuromuscular disorders"-- Provided by publisher.
  • 2013From: ScienceDirect
    Alison McConnell ; foreword by Rik Gosselink ; illustrations by Bruce Hogarth.
    Respiratory Muscle Training: theory and practice is the world's first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts - theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge - and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (, which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via, which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. Introductory overviews of respiratory and exercise physiology, as well as training theory Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation Evidence-based guidance on the implementation of inspiratory muscle resistance training Over 150 functional exercises that incorporate a breathing challenge - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec's RMT exercise module (via
  • 2016 (25th ed.)From: AccessMedicine
    24th ed., 2012From: AccessMedicine
    Barrett, Kim E.; Ganong, William F.
    Also available: Print – 1985-<2016>
  • 2013From: Springer
    Lawrence D. Longo ; foreword by John R.G. Challis.
    During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal breathing movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance. Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants.
  • Emel Demircan.
    Potential benefits from human motion understanding range from rehabilitation and physical therapy to ergonomics design, sports training, and computer animation. Robotics-based reconstruction and synthesis of human motion is a powerful tool to study human motion. Understanding human motion requires accurate modeling of the kinematics, dynamics, and control of the human musculoskeletal system to provide the bases for the analysis, characterization, and reconstruction of their movements. These issues have much in common with the problems found in the studies of articulated body systems in robotics research. Task-based methods used in robotics may be leveraged to provide novel musculoskeletal modeling methods and physiologically accurate performance predictions. However, reproducing and synthesizing the basis of human movements in common robotics frameworks bring the following compelling challenges: Scaling detailed musculoskeletal models to the human subject. Reconstruction and redundancy resolution of human motion in presence of constraints. Characterization of human postural behaviors and dynamic skills. The analysis, control, and reconstruction approaches developed in this thesis deal with these challenges. In motion analysis, methodologies are developed to characterize human postural behaviors and dynamic skills in a unified framework including task, posture, and additional constraints such as contact with the environment and physiological capacity. Information, which is gained from musculoskeletal models that are mapped into the motion of the human, is exploited in a task-oriented simulation and control framework. Task-driven human performance metrics, including the criteria for operational space acceleration characteristics and human muscular effort, are developed and analyzed for human skills. Using these metrics, optimization criteria are introduced that take into account human skeletal kinematics, muscle activation, physiology, and dynamics, and that correlate to the observed motion characteristics. In motion control, algorithms are developed to control human musculoskeletal systems in real-time. A marker space control structure is established for the reconstruction of human motion by direct tracking of marker trajectories. Dynamic consistency between marker space tasks, posture, and additional constraints is achieved by recursive projections into the null spaces of higher priority tasks. The human motion control hierarchy is established in marker space following the natural tree-like branching structure of the human musculoskeletal model. The marker space reconstruction methodology allows computing full human motion dynamics in real-time. In addition, an approach for resolving muscle redundancies is developed based on a new hybrid electromyography and conventional computed muscle control method. These methodologies are validated through three-dimensional dynamic simulations of musculoskeletal models scaled to the subjects. Extensive motion capture experiments are conducted on human subjects of various skill levels including a tai chi master, an elite college-level golfer, a novice golfer, and a professional American footballer for several dynamic movements. Using real-world experimental data, dynamic simulations are exemplarily created and analyzed for golf swings, throwing motions, and gait. The robotics-based reconstruction and synthesis approaches introduced in this thesis provide an important basis for understanding natural human motion. These tools are applicable to efficient robot control and human performance prediction. Another important application is the synthesis of novel motion patterns in the areas of robotics research, athletics, rehabilitation, physical therapy, and computer animation.
  • Bryan Carl Petzold.
    The mechanics of our skin determine how our skin and specialized mechanically-sensitive neurons within it are stressed and strained when touched. Understanding the interplay between skin mechanics and touch sensitivity is paramount in uncovering the fundamental molecular mechanisms underlying touch sensation and in understanding and treating touch insensitivity due to diseases like peripheral neuropathy. Despite this importance, the interplay between skin mechanics and sensitivity is poorly understood. The organism Caenorhabiditis elegans is an excellent model system in which to test the hypothesis that skin mechanics affect touch sensitivity. C. elegans detects body touch with just six mechanically-sensitive neurons. These neurons are embedded in the outer shell (consisting of the cuticle, hypodermis and body wall muscles) of the body plan, which dominates the overall body mechanics. If skin mechanics are important in touch sensitivity in C. elegans, stiffening or softening the outer shell should alter the ability of the animal to detect applied mechanical stimuli. I demonstrate that a piezoresistive cantilever force clamp system and methods that alter C. elegans body mechanics can be combined to directly test the hypothesis that mechanics modulate touch sensitivity. In particular, I build on prior work demonstrating that genetic mutation of cuticle proteins alters body stiffness, and use optogenetic modulation of body wall muscle tone to demonstrate that the body wall muscles modulate C. elegans body mechanics. Combining piezoresistive cantilevers capable of applying minute forces with these techniques to alter the mechanics of the body allows us to directly quantify the affect of body stiffening or softening on force or indentation depth sensitivity in C. elegans. I find that even small shifts in body stiffness have a significant effect on force sensitivity, with body stiffening leading to a reduction in force sensitivity and vice versa. Further, I demonstrate that indentation depth sensitivity is less affected by changes in body mechanics, suggesting that the mechanically-sensitive neurons involved in body touch in C. elegans respond more directly to applied indentation than to applied force. These findings emphasize the importance of considering skin mechanics in understanding the sense of touch and insensitivity due to diseases like peripheral neuropathy.
  • 2014From: CRCnetBASE
    editors, Isaias Dichi, José Wander Breganó, Andréa Name Colado Simão, Rubens Cecchini.
    Section 1. Introduction -- section 2. Oxidative stress and genetic polymorphism -- section 3. Oxidative stress in transmissible chronic diseases -- section 4. Oxidative stress in metabolic diseases -- section 5. Oxidative stress in autoimmune and neurodegenerative diseases -- section 6. Oxidative stress in cancer and cachexia.
  • Kelsey Lynne Clark.
    Spatial attention is known to gate entry into short-term memory, and some evidence suggests that spatial signals may also play a role in binding features or protecting object representations during memory maintenance. To examine a potential role for spatial signals in maintaining object short-term memory, the activity of neurons in the Frontal Eye Field (FEF) of macaque monkeys was recorded during an object-based delayed match-to-sample (DMS) task. In this task monkeys were trained to remember an object identity over a brief delay, irrespective of the locations of the sample or target presentation. FEF neurons exhibited visual, delay, and target period activity, including selectivity for sample location and target location. Delay period activity represented the sample location throughout the delay, despite the irrelevance of spatial information for successful task completion. Furthermore, neurons continued to encode sample position in a variant of the task in which the matching stimulus never appeared in their response field. FEF neurons also exhibited target-position-dependent anticipatory activity immediately prior to target onset, suggesting that the monkeys can predict target position within blocks. These results show that FEF neurons maintain spatial information during short-term memory, even when that information is irrelevant for task performance. Despite the robust delay period activity we observed in FEF during the DMS task, we found little further evidence to support the theory that this activity contributes to object memory maintenance. Noise correlations were present between pairs of simultaneously recorded FEF and IT neurons during the sample and early delay periods, but did not persist into the second half of the delay period, despite the continued elevation of firing rates in both regions throughout the delay. The most direct method of assessing the contribution of the FEF delay period activity observed during the DMS task to object memory was the pharmacological elimination of that activity and evaluation of the impact on task performance. Inactivation of FEF with muscimol produced spatially localized deficits on the memory guided saccade task, but did not selectively impair object memory performance for sample stimuli appearing in the mnemonic scotoma.
  • 2008From: Springer
    edited by Nigel G. Laing.
    The sarcomere and sarcomerogenesis / Elisabeth Ehler and Mathias Gautel -- Skeletal muscle alpha-actin diseases / Kathryn N. North and Nigel G. Laing -- Nebulin : a giant chameleon / Katarina Pelin and Carina Wallgren-Pettersson -- Skeletal muscle disease due to mutations in tropomyosin, troponin, and cofilin / Nigel F. Clarke -- Investigations into the pathobiology of thin-filament myopathies / Biljana Ilkovski -- Mouse models for thin filament disease / Mai-Anh T. Nguyen and Edna C. Hardeman -- Thick filament diseases / Anders Oldfors and Phillipa J. Lamont -- Acute quadriplegic myopathy : an acquired "myosinopathy" / Lars Larsson -- Third filament diseases / Bjarne Udd -- The Z-disk diseases / Duygu Selcen and Olli Carpén -- Intermediate filament diseases : desminopathy / Lev G. Goldfarb ... [et al.] -- Muscular integrity : a matter of interlinking distinct structures via plectin / Patryk Konieczny and Gerhard Wiche -- The sarcomere and the nucleus : functional links to hypertrophy, atrophy, and sarcopenia / Mathias Gautel -- Other model organisms for sarcomeric muscle diseases / John Sparrow, Simon M. Hughes, and Laurent Segalat -- Therapeutic approaches for the sarcomeric protein diseases / Kristen J. Nowak.
    Also available: Print – 2008
  • 2011From: Springer
    Gordon S. Lynch, editor.
    Overview of Sarcopenia -- Muscle wasting in cancer and ageing: cachexia versus sarcopenia -- Age-related remodeling of neuromuscular junctions -- Aging related changes motor unit structure and function -- Excitation-contraction coupling regulation in aging skeletal muscle -- Alterations in mitochondria and their impact in aging skeletal muscle -- Skeletal muscle collagen: age, injury and disease -- Nuclear apoptosis and sarcopenia -- Age-related changes in the molecular regulation of skeletal muscle mass -- Genetic variation and skeletal muscle traits: implications for sarcopenia -- Proteomic and biochemical profiling of aged skeletal muscle -- Exercise and nutritional interventions to combat age-related muscle loss -- Reactive oxygen species generation and skeletal muscle wasting, implications for sarcopenia -- Exercise as a countermeasure for sarcopenia -- Role of contraction-induced injury in age-related muscle wasting and weakness -- Role of IGF-1 in age-related loss of skeletal muscle mass and function -- Role of myostatin in skeletal muscle growth and development: implications for sarcopenia -- Role of beta-adrenergic signalling in skeletal muscle wasting: implications for sarcopenia -- Index.
  • 2007From: Springer
    Roland Rau.
  • Purkyně, Jan Evangelista.
    Status: Not Checked OutLane Catalog Record
    --sv. 2-5. [without special title].--sv. 6. Disertace Purkyňových žáků.--sv. 7. České práce fysiologické a morfologické.--sv. 8. Úvahy a pracé přírodovědné.--sv. 9. Věda, výchova, společnost, studie a úvahy.--sv. 10. Slavistické pracé.--sv. 11. Básně a překlady.--sv. 12. Fysiologie lidské mluvy a menší fysiologickě pracé.--sv. 13. Autobiografické stati. Bibliographia.
  • Johan Oscar Lennart Andreasson.
    Kinesin family proteins are nanoscale motors involved in many essential biological processes, such as intracellular transport and cell division. The biological function of most kinesin motors is to use the energy from ATP hydrolysis to move cargo through a crowded cellular environment, quickly taking 8-nm steps along cytoskeletal microtubules. By maintaining its two motor domains (heads) out of phase, kinesin can complete hundreds of steps per encounter with the microtubule, and can do so against pN-scale loads. The physiological role of kinesin is directly related to its movement and in this dissertation I present several single-molecule studies where the force-dependent motion of individual kinesin motors was studied using optical trapping techniques. In humans, the kinesin superfamily includes over forty genes encoding different kinesin proteins, classified into 15 families, and motors from several families were studied in this work. Optical traps use lasers to detect the position of biological molecules, at nm-scale resolution, and to directly manipulate them by applying pN-scale forces. In this dissertation, I present two novel optical traps. The first uses highly linear electro-optic deflection of the laser light to create an instrument with fast feedback that is optimized for work with kinesin motors. The second instrument, an "Optical Torque Wrench", is a trap that can apply both forces and torques on birefringent particles. By controlling the light polarization in the sample plane, the rotation of nanofabricated quartz cylinders can be controlled in real time while the applied torque is measured directly. The functionalized particles can be used to twist DNA or other biological molecules. The kinesin motor domains are coordinated during stepping and the inter-head communication is believed to be conferred by the neck linker, a 14-amino acid structural element connecting the head to the common coiled-coil stalk. By extending this segment, we could examine its role in gating the mechanochemical cycle. A six-amino acid insert in the neck linker of a cysteine-light human kinesin construct led to unexpected ATP-dependent backstepping under load. These observations could be explained by a branched pathway where both ATP unbinding and hydrolysis were gated by the direction of the neck linker. Lengthening the neck linker also led to futile hydrolysis. Further experiments on the effects of neck linker length were done with a series of Drosophila Kinesin-1 mutants, with one to six extra residues in the neck linker. The rate of force-dependent rear head release and the internal strain developed during stepping was determined from force-dependent velocities and we also found that the mechanism of detachment from the microtubule depends on the direction of load. The heterotrimeric Kinesin-2 motors are unique in that they are the only kinesin family motors that consist of two different catalytic domains. Here, the mammalian Kinesin-2, KIF3A/B, was studied in detail by performing optical trapping experiments with both the wild-type dimer and with homodimers (KIF3A/A and KIF3B/B). A pathway that incorporates the individual catalytic cycles for KIF3A and KIF3B could explain all force- and ATP-dependent kinetics and surprisingly we found that the run lengths for KIF3A/B were significantly shorter than for Kinesin-1. Furthermore, motors with the weakly force-dependent KIF3A head "slipped" and exhibited short run lengths that were rescued under no load, indicating that KIF3A/B combines a Kinesin-1-like motor domain (KIF3B) with a unique and "weak" one (KIF3A). Finally, I present motility experiments where force-dependent kinetics were explored for several other kinesin family motors. KIF17 (Kinesin-2) and CENP-E (Kinesin-7) are robust, processive motors whereas KIF4A, a Kinesin-4 motor, is fast but unable to sustain significant loads. These results, together with those for Kinesin-1, KIF3A/B (Kinesin-2), and other motors, show that forces are needed fully reveal the motor characteristics and differences between various kinesin proteins. They also illustrate the remarkable diversity within the kinesin superfamily.
  • 2006From: Springer
    edited by Roberto Bottinelli and Carlo Reggiani.
  • 2008From: Springer
    edited by Stefano Schiaffino and Terence Partridge.
  • 2005From: Springer
    edited by Haruo Sugi.
    Also available: Print – 2005
  • 2013From: ClinicalKey
    edited by F. Paulsen and J. Waschke ; translated by T. Klonisch and S. Hombach-Klonisch.
    Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. An additional booklet containing 100 tables on muscles and nerves supports systematic study. Volume 1 "General Anatomy and Musculoskeletal System" includes the following topics: General Anatomy Trunk Upper Extremity Lower Extremity.
  • 2015From: Springer
    Kazuyuki Kanosue, editor in chief ; Tomoyuki Nagami, Jun Tsuchiya, editors.
  • Chand Thomas John.
    Walking is the primary way in which humans move around in daily life. Stroke, injuries, or neuromuscular disorders such as cerebral palsy can impair an individual's ability to walk, thereby making activities of daily life much more difficult. Treatment of walking disorders targets muscles, but the mechanisms by which muscle forces influence body motion are poorly understood. Because important quantities like muscle forces cannot be measured during movement, experimental methods alone are insufficient for improving our understanding of the cause-effect relationships underlying the control of human walking. Muscle-driven simulations have emerged as powerful tools for calculating muscle forces and investigating how muscle forces influence body motion. This dissertation presents a new "residual reduction algorithm" for improving the consistency in a model between motion and force data collected during motion capture, enabling the generation of simulations of long-duration gait movements such as walking and running. This algorithm has enabled hundreds of researchers around the world to generate simulations of walking. This algorithm was used to generate a thoroughly tested, three-dimensional muscle-driven simulation of an unimpaired man walking for ten gait cycles. This simulation has been made freely available at so other researchers can download, reproduce, modify, and analyze this simulation to investigate questions regarding human walking without having to generate their own simulations from their own motion capture data, thereby saving thousands of man-hours of time for the field of computational biomechanics. We used this simulation to resolve a long-standing mystery in movement science: how the human body responds to external disturbances when the central nervous system's responses are substantially delayed. We showed that intrinsic properties of muscles help stabilize walking by responding instantaneously to disturbances, thereby complementing the central nervous system's delayed response. This study demonstrates the utility of simulations for investigating questions about human walking that cannot be explored with experimental methods alone. The residual reduction algorithm also enabled the generation of 32 simulations of eight subjects walking at four different speeds. We analyzed these simulations to determine which muscle groups make the largest contributions to mediolateral ground reaction force across a range of speeds. We showed that walking speed affects peak lateral ground reaction force in early stance and peak medial ground reaction force during early single support. The hip abductors are the largest contributors of medial ground reaction force at all walking speeds. The calf muscles, knee extensors, and adductors oppose the abductors by contributing lateral ground reaction forces. The work presented in this dissertation has enabled several studies to be performed using muscle-driven simulations to gain insight into how muscles modulate walking and running movements. This dissertation presents two such studies that reveal insight into how muscle properties help stabilize walking and how muscles contribute to mediolateral stability during walking.
  • 2014From: CRCnetBASE
    Yin Bun Cheung.
    "Human growth refers to changes in anthropometric measurements, such as fetal size parameters, height, weight, and body mass index. Development refers to changes in cognitive, social-emotional, locomotor, and other abilities. This book illustrates how statistical methods can be used to answer research questions in human growth and development. In addition to describing methods, it looks at how well a method addresses a specific research question and how to interpret and present the analytic results. Although the examples are drawn from human growth and development, the concepts and methods are applicable to studies of many other physical and psychological phenomena, such as lung function and depressive symptoms. Requiring introductory statistics knowledge, the book is intended for clinical researchers, epidemiologists, social scientists, statisticians, related researchers, and post-graduate students investigating human growth and development"--Provided by publisher.
  • Pamela Flood, MD, MA, Professor of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California ; James P. Rathmell, MD, Executive Vice Chair and Chief, Division of Pain Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Henry Knowles Beecher Professor of Anaesthesia, Harvard Medical School, Boston, Massachusetts ; Steven Shafer, MD, professor of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California.
    Status: Not Checked OutLane Catalog Record
    PART I: Basic principles of physiology and pharmacology -- Basic principles of physiology / Pamela Flood, Seven Shafer -- Basic principles of pharmacology / Pamela Flood, Seven Shafer -- PART II: Neurologic system -- Neurophysiology / Pamela Flood, Seven Shafer -- Inhaled anesthetics / Pamela Flood, Seven Shafer -- Intravenous sedatives and hypnotics / James P. Rathmell, Carl E. Rosow -- Pain physiology / Hui Yang, Bihua Bie, Mohamed A. Naguib -- Opioid agonists and antagonists / Kenneth Cumming III, Mohamed A. Naguib -- Centrally acting nonopioid analgesics / Hesham Elsharkawy, Mohamed A. Naguib -- Peripherally acting analgesics / Hesham Elsharkawy, Mohamed A. Naguib -- Local anesthetics / Kamal Maheshwari, Mohamed A. Naguib -- Neuromuscular physiology / Mohamed A. Naguib -- Neuromuscular blocking drugs and reversal agents / Mohamed A. Naguib -- Antiepileptic and other neurologically active drugs / Pamela Flood, Mark Burbridge -- PART III: Circulatory system -- Circulatory physiology / James Ramsay, Barrett Larson -- Cardiac physiology / Sumeet Goswami, Bessie Kachulis, Teresa A. Mulaikal, Jack S. Shanewise -- Renal physiology / Jonathan Hastie, Jack S. Shanewise -- Intravenous fluids and electrolytes / Jessica Spellman, Jack S. Shanewise -- Sympathomimetic drugs / Sansan S. Lo, Jack S. Shanewise -- Sympatholytics / Steven Miller -- Vasodilators / James Ramsay, Carter Peatross -- Antiarrhythmic drugs / James Ramsay, Nicholas Anast -- Diuretics / Maya Jalbout Hastie, Jack S. Shanewise -- Lipid-lowering drugs / Sarah C. Smith, Jack S. Shanewise -- PART IV: Pulmonary system -- Gas exchange / Peter Slinger -- Respiratory pharmacology / Peter Slinger -- Acid-base disorders / Peter Slinger -- PART V: Blood and hemostasis -- Physiology of blood and hemostasis / Jerrold H. Levy -- Blood products and blood components / Jerrold H. Levy -- Procoagulants / Jerrold H. Levy -- Anticoagulants / Jerrold H. Levy -- Physiology and management of massive transfusion / Jerrold H. Levy -- PART VI: Gastrointestinal system and metabolism -- Gastrointestinal physiology / Michael J. Murray -- Metabolism / Michael J. Murray -- Antiemetics / Michael J. Murray, David A. Grossblatt -- Gastrointestinal motility drugs / Michael J. Murray, Jillian A. Maloney -- Nutrition / Michael J. Murray -- PART VII: Endocrine system -- Normal endocrine function / Vivek K. Moitra -- Drugs that alter glucose regulation / Vivek K. Moitra -- Drugs for the treatment of hypothyroidism and hyperthyroidism / Vivek K. Moitra -- Other endocrine drugs / Vivek K. Moitra -- PART VIII: Miscellaneous -- Antimicrobials, antiseptics, disinfectants, and management of perioperative infection / Pamela Flood -- Chemotherapeutic drugs / James P. Rathmell, Mihir M. Kamdar -- Drugs used for psychopharmacologic therapy / Joseph Kwok, Pamela Flood -- PART IX: Special populations -- Physiology of the newborn / Pamela Flood -- Maternal and fetal physiology and pharmacology / Pamela Flood -- Physiology and pharmacology of the elderly / Pamela Flood -- Physiology and pharmacology of resuscitation / Michael J. Murray.
  • 2012From: Springer
    Alexander Choukèr, editor.
    This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system.
  • Jordan Michael Nechvatal.
    Exposure to stress is a risk factor for the development of subsequent mental illness. Far less researched, but of equal importance, are indications that coping with stressors that are challenging but not overwhelming may lead to the development of resilience. Coping appears to counteract the deleterious effects of stress and is thought to induce long-lasting adaptations in corticolimbic brain systems. My research tests this hypothesis in a series of inter-related studies. First, I considered how learning as an aspect of coping in the context of stress exposure psychotherapy changes the human brain. I conducted a systematic review of the literature and identified 15 brain imaging studies in which human patients with specific phobias or posttraumatic stress disorder were randomized to stress exposure psychotherapies that effectively diminished subsequent indications of anxiety. Exposure psychotherapies also consistently changed amygdala activity in four of the studies. Less consistent prefrontal changes were reported in seven different studies. In contrast to these studies of functional changes in brain activity, only one study was designed to look for structural changes in the brain. Whether stress coping alone is sufficient to induce prefrontal and amygdala adaptations is also not known as coping in the context of stress exposure psychotherapy in several of the studies included additional professional training to enhance cognitive restructuring, relaxation, guided mastery, and diverse forms of psychoeducation. Practical limitations and ethical concerns restrict opportunities for randomized controlled trials of stress coping effects on the human brain. Therefore, I studied a monkey model to determine whether stress coping experiences that occur early in life without additional interventions induce long-lasting adaptations in amygdala and prefrontal brain regions. Using in vivo structural neuroimaging and a randomized longitudinal approach, I found that prefrontal gray matter volumes decrease more at older ages than total brain volumes with less of a decrease observed in monkeys exposed to early life stress coping compared to no stress coping controls. These findings suggest that stress coping produces a brain-reserve that lessens the impact of subsequent normal age-related prefrontal gray matter decline. Stress coping had no effect on amygdala volumes across life-span development, but whole brain exploratory voxel-based morphometry revealed larger ventral striatum gray matter volumes in stress coping compared to no stress coping control monkeys at both 3 and 9 years of age. In a previously published study, stress coping effects were also observed in prefrontal white matter at 3 years of age, but prefrontal white matter volume treatment effects were not discerned in my study at any age. A possible explanation for this discrepancy is the use of diffusion tensor brain imaging in the previously published study to provide a more sensitive measure of white matter myelination. To determine whether stress coping-induced white matter differences previously observed at 3 years of age extend into adulthood, I used diffusion tensor imaging combined with tract-based spatial statistics in the same cohort of monkeys at 9 years of age. Tract-based spatial statistics localized significantly increased fractional anisotropy in bilateral uncinate fasciculus and right external capsule of stress coping compared to no stress coping control animals. Stress coping had no effect on fractional anisotropy in prefrontal white matter regions previously identified at 3 years of age. These data suggest that stress coping induces temporal dynamic prefrontal white matter microstructural changes together with long-lasting increased white matter tract integrity between frontal and limbic regions. Collectively, these studies deepen our understanding of stress neurobiology. According to the World Health Organization, stress will be the second leading cause of all medical disabilities by the year 2020. The American Institute of Stress has determined that 75-90% of medical visits are stress-related and may cost the nation more than 42 billion dollars each year. My research provides neurobiological insights for the development of diagnostic tools and therapeutics that mimic or enhance stress coping and recovery from stress-related mental illness.
  • Jennifer Lynn Stamos.
    A great deal is known about elements of the Wnt signal transduction cascade and the [beta]-catenin destruction complex, but a complete molecular understanding of their function has remained elusive. Many of the proteins that are necessary for [beta]-catenin destruction, including GSK-3, CK1, Axin, and APC, also have roles in stabilizing [beta]-catenin on Wnt stimulation, thus confounding genetic analyses and cell culture overexpression studies in difficult-to-predict ways. In addition, Wnt signal transduction proteins such as GSK-3, CK1, and APC play critical roles in other signal transduction and metabolic cascades within cells, including such diverse pathways as glycogen regulation, circadian rhythm, spindle formation during mitosis, and microtubule stability. In order to carefully dissect Wnt signal transduction in the absence of these confounding factors, biochemical and structural studies were carried out on proteins from the destruction complex and the Wnt signaling cascade, with emphasis placed on the role of phosphorylation events on the APC, [beta]-catenin, and LRP5/6 proteins during the transition from [beta]-catenin destruction to activation.
  • Karen Newton Colbert.
    A defining feature of eukaryotic cells is the compartmentalization of membrane-bound organelles with specialized functions. Movement of cargo between compartments, and exchange of material into and out of a cell are fundamental to cellular viability and effective communication with other cells. Secretion of neurotransmitters, the process by which neurons relay information, occurs when neurotransmitter-containing vesicles fuse with the target membrane in a pre-synaptic nerve terminal. Members of the SNARE, SM, and AAA+ ATPase protein families are central mediators of the exquisitely regulated process of neurotransmission. SNARE proteins form a complex that drives the fusion of synaptic vesicles with the target membrane; the SM protein Munc18a is a crucial mediator of SNARE complex assembly, and the ATPase NSF disassembles SNARE complex following neurotransmitter secretion, recycling SNAREs for subsequent rounds of vesicle fusion. The work presented here describes structural, biophysical, and biochemical approaches used to investigate the mechanism by which Munc18a, SNAREs and NSF orchestrate synaptic vesicle fusion.
  • Gary A. Thibodeau, Kevin T. Patton.
    Status: Not Checked OutLane Catalog Record
  • 2009From: ClinicalKey
    [edited by] Thomas J. Errico, Baron S. Lonner, Andrew W. Moulton.
    A who's who in this challenging field brings you state-of-the-art approaches to the full range of surgical management options, including reconstructive procedures, for the pediatric and adult patient with spinal deformity. Experts discuss the course of treatment for patients in different age groups and take into consideration the extent of the curve at the time of diagnosis and during follow-up, the patient's stage of bone growth, the amount of pain and deformity associated with the condition, and the patient's willingness and ability to withstand surgery. Plus, a section on general information such as practical surgical anatomy, imaging, applied biomechanics, and instrumentation helps you approach each patient more effectively. The included DVD helps you perfect your technique with narrated surgical procedures. Emphasizes technical skills and surgical decision making, including pearls, pitfalls, and illustrative case studies, offering you expert advice on technically challenging surgeries. Provides the very latest information on minimally invasive endoscopic and mini-open approaches to broaden your surgical options and minimize post-operative complications. Discusses peri-operative considerations, including anesthesia, blood loss management, bone graft and fusion enhancement, neural monitoring, and complications, keeping you prepared for any event. Presents full-color line artwork of surgical procedures as well as diagnostic and clinical photographs for superb visual guidance. Offers a consistent format throughout and a full-color design for ease of reference. Website includes a video library of narrated surgical procedures to help you master your technique.
  • 2012From: AccessMedicine
    George V. Lawry.
    A step-by-step learning text and atlas designed to teach essential and foundational skills of musculoskeletal physical assessment. Comprised of a 3-part learning system: 1. Screening Musculoskeletal Examination (SMSE): rapid assessment of structure and function 2. General Musculoskeletal Examination (GMSE): comprehensive assessment of joint inflammation and arthritis 3. Regional Musculoskeletal Examination (RMSE): focused assessments of structure and function combined with special testing of the shoulder, knee, and neck and low back.
    Also available: Print – 2012
  • 2014From: Springer
    Matej Orešič, Antonio Vidal-Puig, editors.
  • Mandy Miller Koop.
    Hypokinesia is one of the most disabling movement abnormalities caused by Parkinson's disease (PD). It is a clinical term that refers to the general reduction of mobility experienced by people with Parkinson's disease (PWPD). Hypokinesia affects movements in three ways: 1) movements are slow 2) movements are performed with reduced amplitude compared to what is required for the task and 3) it takes longer for PWPD to initiate movements. All of these impairments affect the ability of PWPD to perform common daily activities and can cause feelings of frustration and anger that may lead to altered self esteem, depression, and a reduction in their quality of life. Although effective treatments do exist for well-selected patients, there are many avenues open for improving current treatments, identifying new treatments, and understanding mechanisms of hypokinesia that could potentially lead to more effective therapies and greatly impact the lives of PWPD. In this dissertation we sought to improve current treatments and provide opportunities for future treatments for hypokinesia by addressing three important clinical questions relating to hypokinesia. First, are there immediate improvements in hypokinesia from a surgical procedure called deep brain stimulation (DBS) that can be measured during surgery and used to help guide surgical decisions and optimize clinical outcomes? Second, can we determine what types of movements are affected by hypokinesia in early stage, untreated PD in order to provide an objective metric used to assess an emerging treatment for PD? Third, might perceptual deficits that are linked to sensory processing impairments play a role in the manifestation of hypokinesia? If so, targeting these deficits may provide new and better therapies. We addressed these questions by using the quantitative and computational techniques outlined in the next three paragraphs. A common treatment for advanced PD is a surgical procedure called DBS. The surgery is performed on awake patients, and it entails surgically implanting electrodes (leads) that provide chronic stimulation to the affected brain area that controls movement. Although the treatment is almost always effective, the degree of improvement in hypokinesia varies among patients. The accuracy of the placement of the DBS lead in the affected area is believed to have the most effect on the improvement of hypokinesia. We suggest that using quantitative measurements of hypokinesia to evaluate the efficacy of the location of the DBS lead in improving hypokinesia during the surgical procedure might therefore improve the overall clinical outcomes. The surgical team would then have objective, accurate measurements of the degree of improvement in hypokinesia during the surgery, when the lead's position in the brain could be modified to achieve optimal results. Therefore, we designed a prospective study to measure upper extremity hypokinesia using a quantitative measure of angular velocity. Analysis of 98 DBS procedures performed on 61 patients showed that on average there was an 81% improvement in quantitative measures of hypokinesia from implanting and activating the DBS lead (p< 0.03). This study demonstrated that objective, high-resolution, accurate measurements of improvements in hypokinesia from intra-operative DBS are possible in this highly constrained environment and could therefore be used to help guide surgical decisions and optimize clinical outcomes. PD has no cure, but treatments in the near future may include disease-slowing medications. Although few studies have characterized the motor control abnormalities of very early stage PD, when symptoms are mild and usually unilateral, this group is the most targeted for potential disease-modifying therapeutics. In this study, we asked if quantitative measures of finger, limb, and postural movement velocity could detect hypokinesia in 20 patients with very early stage, untreated PD. The results revealed evidence of significant finger and limb hypokinesia of the patient group's more affected side when compared to the non-dominant side of 19 age-matched healthy adults (HAs) (p=0.001 and p< 0.001, respectively). Furthermore, the patient group's limb movement velocity on the more affected side was significantly slower than their less affected side (p=0.005), highlighting the importance of using an outcome measure that is lateralized in studies of very early stage PD. In contrast to our previous study that revealed significant postural hypokinesia in patients with advanced PD, we did not detect postural hypokinesia in patients with very early stage, untreated PD. Based on these findings, we suggest that the use of quantitative lateralized measures of hypokinesia would be useful in neuroprotective clinical studies of very early stage, untreated PD and may improve the chances of detecting a disease-modifying effect of potential neuroprotective therapeutics. Detecting such a therapy would have a large impact by improving the lives of PWPD. Although hypokinesia is considered a movement abnormality, new research is suggesting that perceptual deficits may play a role in the manifestation of abnormal movements in PWPD. Motor control theory posits that a sensorimotor integration process (SIP) is used by the central nervous system to perceive and control movement by combining internally generated predictions of movement parameters with the processing of sensory feedback. A previous study examining the SIP demonstrated that HAs overestimated their limb position in the direction of movement, and that the error and its variance (VOE) depended on movement duration. Using quantitative measures of hypokinesia, we asked if PWPD showed errors in perceived limb position and if the dependence on movement duration was different from HAs. We used an established computational model of the SIP to explore mechanisms for the error and VOE as a function of movement duration. Twenty PWPD, off medication, and 20 age-matched HAs were asked to estimate the position of their hand after performing 50, slow, non-visually guided wrist flexion or extension movements for a random period of time (< 4.0 sec). Both groups overestimated the amount they moved; however, the PWPD's error and VOE were larger (p< 0.001). More specifically, HAs exhibited increasing error/VOE for small movement durations that reduced/stabilized for longer movement durations. PWPD, however, showed increasing error/VOE with increasing movement duration that did not significantly improve/stabilize. The results from the model revealed an 88% increase in the variance (noise) in the sensory feedback parameter in PWPD compared to HAs, which suggests the PWPD's SIP could no longer effectively access sensory feedback information to correct errors in other components of the SIP due to the large amount of noise in this signal. This study provides experimental evidence that perceptual deficits may play a role in hypokinesia and computational evidence that abnormal processing of sensory feedback in PWPD's SIP could contribute to increased perceptual error in limb position after non-visually guided movements. The work in this dissertation quantified the immediate improvements in hypokinesia from intra-operative DBS, the presences of hypokinesia in early stage, untreated PD, and the degree of perceptual deficits and their dependency on movement duration in PD. Furthermore, this research has provided evidence for possible mechanisms for hypokinesia. Taken together, this work has the possibly to provide immediate improvements for current treatments and provides several platforms for future therapies to treat hypokinesia and improve the lives of PWPD.
  • 2006From: Springer
    edited by Simo S. Oja and Pirjo Saransaari.
    Also available: Print – 2006
  • 2009From: Springer
    Junichi Azuma, Stephen W. Schaffer, Takashi Ito, editors.
    Also available: Print – 2009
  • v. 1-2, 2013.From: Springer
    v.2From: Springer
    Abdeslem El Idrissi, William J. L'Amoreaux, editors.
    Volume 1. The Nervous system, immune system, diabetes and the cardiovascular system -- Volume 2. Nutrition and metabolism, protective role, and role in reproduction, development, and differientiation.
    Also available: Print – v. 1-2, 2013
  • 2015From: Springer
    Janusz Marcinkiewicz, Stephen W. Schaffer, editors.
    Taurine 9 contains original articles and critical reviews based on the oral and poster presentations of XIX International Taurine Meeting held in Kraków, Poland in May 2014. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.
    Also available: Print – 2015
  • 2008From: Thieme Book
    [edited by] Peter L. Munk, Anthony G. Ryan.
    I. Internal Joint Derangement; II. Tumors; III. Infection; IV. Avascular bone; V. Trauma; VI. Arthritis.
  • 2010From: ClinicalKey
    Hugue A. Ouellette.
  • 2012From: ClinicalKey
    editor-in-chief, Jin Bo Tang ; editors, Peter C. Amadio, Jean-Claude Guimberteau, James Chang ; contributing editors, David Elliot, Judy Colditz.
    "Get the best results from the latest procedures with Tendon Surgery of the Hand , the only reference that offers comprehensive coverage of this complex and challenging area. World-renowned experts guide you through all of the newest techniques and technologies , equipping you to restore optimal function in your patients. It's your one-stop source for mastering today's best approaches to treating tendon injuries and disorders of the hand."--Publisher's website.
  • 2008From: Karger
    volume editor, Frank E. Marino.
    The evolutionary basis of thermoregulation and exercise performance / F.E. Marino -- Comparative thermoregulation and the quest for athletic supremacy / F.E. Marino -- Thermoregulation, fatigue, and exercise modality / R. Tucker -- Neuromuscular response to exercise heat stress / S.S. Cheung -- Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : the "canary in the coal mine" during exercise-heat stress? / G.P. Lambert -- Effects of peripheral cooling on characteristics of local muscle / E. Drinkwater -- Cooling interventions for the protection and recovery of exercise performance from exercise-induced heat stress / R. Duffield -- Ethnicity and temperature regulation / M.I. Lambert, T. Mann, J.P. Dugas -- Exercise heat stress and metabolism / T. Mündel.
    Also available: Print – 2008
  • Catherine Elizabeth Chang.
    Functional magnetic resonance imaging (fMRI) based on blood-oxygen level dependent (BOLD) contrast is a powerful technique for non-invasive measurement of brain activity. Recent fMRI studies have revealed that the spontaneous BOLD fluctuations of the human brain organize into distributed, temporally-coherent networks ("resting-state networks"; RSNs). Examination of RSNs has yielded valuable insight into neural organization and development, and demonstrates potential as a biomarker for conditions such as Alzheimer's disease and depression. However, the accuracy by which the spatio-temporal properties of RSNs can be delineated using fMRI is compromised by the presence of physiological (cardiac and respiratory) noise and vascular hemodynamic variability. Further, our present understanding of how RSNs may interact and support cognitive function has been limited by the fact that the vast majority of studies to-date analyze RSNs in a manner that assumes temporal stationarity. Here, we describe efforts to correct for non-neural physiological influences on the BOLD signal, as well as investigations into the dynamic character of resting-state network connectivity. It is found that low-frequency variations in cardiac and respiratory processes account for significant noise across widespread gray matter regions, and that a constrained deconvolution approach may prove effective for modeling and reducing their effects. Application of the proposed noise-reduction procedure is observed to yield negative correlations between the spontaneous fluctuations of two major RSNs. The relationship between respiratory volume changes and the BOLD signal is further examined by simultaneously monitoring and comparing chest expansion data, end-tidal gas concentrations, and spontaneous BOLD fluctuations. The use of a breath-holding task is proposed for quantifying regional differences in BOLD signal timing that arise from local vasomotor response delays; such non-neural timing delays are found to impact inferences of resting-state connectivity and causality. Finally, a preliminary analysis of non-stationary connectivity between RSNs is performed using wavelet and sliding-window approaches, and it is observed that interactions between networks may reconfigure on time-scales of seconds to minutes.
  • Feng Chen.
    While there has been great progress in identifying stem and progenitor cells and the signals that control their proliferation and differentiation, how stem/progenitor cells exit their niche and how they form new tissue is not well understood. Unlike in the embryo, tissue formation in an adult animal faces new challenges such as longer distances to migrate and a complex milieu of differentiated tissue to migrate around and/or coordinate with. To restore function to a tissue, stem/progenitor cells must also integrate into healthy tissue and coordinate growth with decaying tissue. In this thesis, I examine how tracheal progenitor cells exit their niche to form tracheal tissue during Drosophila melanogaster metamorphosis. Tracheal progenitors exit the niche in two waves. During the first wave, progenitors migrate onto the basal surface of larval tracheal branches destined for destruction, and track along the decaying branches. Progenitor outgrowth requires the embryonic tracheal branch inducer, Breathless FGFR, and surprisingly, the Branchless FGF ligand is expressed in larval branches along which progenitors crawl. In this way, outgrowth is coordinated with tissue decay. Progenitors that remain within the niche during the first wave exit later. However, instead of moving onto the basal surface of larval branches, progenitors exiting the niche during this second wave move along the apical surface, displacing larval cells, and repopulating the tracheal branch. This latter process does not resemble branching morphogenesis in the embryo and does not require Bnl/Btl FGF signaling, demonstrating that progenitor outgrowth does not always require embryonic guidance cues.
  • 2009From: Thieme
    Philipp Richter, Eric Hebgen ; [translator, Sabine Wilms].
    Muscle chains / Philipp Richter: introduction -- Models of myofascial chains -- Physiology -- The craniosacral model -- The biomechanical model of John Martin Littlejohn : the mechanics of the spinal column -- Postural muscles, phasic muscles, and crossed syndrome (Vladimir Janda's contribution to myofacial treatment methods) -- Zink patterns -- Myofascial chains : a model -- Posture -- Diagnosis -- Therapy -- Trigger points and their treatment / Eric hebgen: Definition -- Classification of trigger points -- Pathophysiology of trigger points -- Diagnosis -- Trigger point therapy -- Trigger point-sustaining factores -- The facilitated segment -- The trigger points.
  • 2015From: Springer
    Enzo Silvestri, Alessandro Muda, Davide Orlandi ; foreword by Nicola Maffulli.
    The book provides a comprehensive description of the basic ultrasound principles, normal anatomy of the lower limb muscles and classification of muscle strain injures. Ultrasound images are coupled with anatomical schemes explaining probe positioning and scanning technique for the various muscles of the thigh and leg. For each muscle, a brief explanation of normal anatomy is also provided, together with a list of tricks and tips and advice on how to perform the ultrasound scan in clinical practice. This book is an excellent practical teaching guide for beginners and a useful reference for more experienced sonographers.
  • Melanie Diane Fox.
    Many children with cerebral palsy walk with a stiff knee gait, or a reduction and delay in swing phase knee flexion, which causes tripping or energy-inefficient compensatory movements. Since over-activity of the rectus femoris muscle is frequently implicated as the cause, a common treatment is transfer of the distal end of the rectus femoris from its insertion on the patella to a location behind the knee. Outcomes, though positive on average, vary among individuals, with some patients demonstrating unimproved or worsened knee flexion postoperatively. This variability is due in part to insufficient understanding of the biomechanical causes of stiff-knee gait and the functional effects of surgical treatment. The goal of this dissertation was to clarify the causes of stiff-knee gait and examine the biomechanical mechanism of improvement following rectus femoris transfer surgery. Swing-phase rectus femoris activity is commonly thought to cause of stiff-knee gait, despite evidence that many patients have excessive knee extension moments in preswing rather than swing phase. We compared the effects of preswing to swing phase activity of the rectus femoris on peak knee flexion in swing by creating and analyzing musculoskeletal simulations of subjects with stiff-knee gait. We found that in six out of ten subjects preswing rectus femoris activity had at least a 90% higher effect on peak knee flexion than swing phase rectus femoris activity, suggesting that preswing rectus femoris activity is an important factor limiting knee flexion in some subjects and should be examined to better determine the factors leading to stiff-knee gait. To understand how other muscles, besides rectus femoris, may limit knee flexion in stiff-knee gait, it is first necessary to understand how muscles coordinate successful swing phase knee flexion in unimpaired gait and how muscle contributions change with walking speed, since many stiff-knee subjects walk slowly. We analyzed simulations of unimpaired subjects walking at different speeds to determine the muscles that accelerated and decelerated knee flexion prior to swing. We found that preswing knee flexion acceleration was achieved primarily by the hip flexor muscles with help from biceps femoris short head, suggesting that weakness in these muscles may contribute to stiff-knee gait. Vasti and soleus decelerated knee flexion, suggesting over-activity in these muscles may contribute to stiff-knee gait. We also investigated the mechanism of improvement following rectus femoris transfer surgery. We altered the geometry of rectus femoris and simulated the dynamics of the swing phase of subjects with stiff-knee gait after different surgical procedures. Analysis of the simulations demonstrated that knee flexion may be improved with a reduction of the knee extension moment generated by the rectus femoris, even if the muscle is not converted to a knee flexor. This dissertation clarifies preswing rectus femoris activity as a cause of stiff-knee gait, demonstrates the functional mechanism of improvement following transfer surgery, and informs future research investigating other potential contributors to stiff-knee gait.
  • [author, Robert B. Dunn ; contributors, Wazir Kudrath, Stanley S. Passo, L. Britt Wilson].
    Status: Not Checked OutLane Catalog Record
    Section I. Fluide distribution and edema -- Section II. Excitable tissue -- Section III. Skeletal muscle -- Section IV. Cardiac muscle mechanics -- Section V. Peripheral Circulation -- Section VI. Cardiac Cycle and Valvular Heart Disease -- Section VII. Respiration -- Section VIII. Renal Physiology -- Section IX. Acid-Base Disturbances -- Section X. Endocrinology -- Section XI. Gastrointestinal Physiology -- Index.
  • 2015From: Springer
    Beate Brand-Saberi, editor.
    This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body. Particular attention is paid to novel regulatory molecules and signals as well as to the heterogeneity of origin that have revealed a developmental overlap between skeletal and cardiac muscle. Different functional muscle groups are the product of the evolution of the vertebrate classes, making a phylogenetic comparison worthwhile for understanding the role of muscle stem cells and precursors in myogenesis. New insights into the hierarchy of transcription factors, particularly in the context of these different muscle groups come from detailed investigations of the spatio-temporal and regulatory relationships derived from mouse and zebrafish genetics and avian microsurgery. Importantly, epigenetic mechanisms that have surfaced recently, in particular the role of MyomiRs, are also surveyed. Regarding human patients, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers that share regulatory molecules. Interestingly, the heterogeneity in embryonic origins of skeletal muscle groups in the vertebrate including humans is paralleled by their different susceptibility to types of muscle dystrophies. The progress that has been made in the field of muscle stem cell biology, especially on satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. An improved understanding of muscle stem cells seems only possible with a view to the cell environment, putting embryological and molecular findings from different vertebrate classes and stem cell approaches into context.
    Also available: Print – 2015
  • 2006From: Springer
    Dan W. Urry.
    What sustains life? an overview -- The pilgrimage: highlights in our understanding of products and components of living organisms -- Likelihood of life's protein machines: extravagant in construction yet efficient in function -- Consilient mechanisms for diverse protein-based machines: the efficient comprehensive hydrophobic effect -- On the evolution of protein-based machines: toward complexity of structure and diversity of function -- Biology thrives near a movable cusp of insolubility -- Consilient mechanisms for the protein-based machines of biology -- Advanced materials for the future: protein-based materials with potential to sustain individual health and societal development -- Appendix 1. Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction / Dan W. Urry and Timothy M. Parker -- Appendix 2. Development of elastic protein-based polymers as materials for acoustic absorption / Dan W. Urry... [et al.]
  • Thomas Wright.
    Prologue. A new theory (1636) : 'Blood moves ... in a circle, continuously' -- pt. 1. Raising himself from the ground. A Kentish upbringing (1578-1593) : 'Half farmer and half gentleman' ; Cambridge studies I (1593) : 'Making low legs to a nobleman' ; Cambridge studies II (c.1593-1599) : 'Devoting himself assiduously to his studies' ; Essay 1. Galen, Mondino, and Vesa lius : a brief history of anatomy ; Padual studies I (1599-c1600) : 'Fair Pauda, nursery of the arts' ; Essay 2. A dissection of sacred hearts, feeling hearts, and thinking hearts ; Padual studies II (c.1600-1602) : 'The explosion of anatomy' ; Early years in London (c.1602-c.1610) : 'Begin the world' ; Advances (c.1610-c.1625) : 'Good endeavours bring forth much good frute' -- pt. 2. Placing his head among the stars. A public lecture I (Late 1610s) : Nasty (yet recompensed by admirable variety'
  • v. 1-2, 2008.From: Springer Protocols
    v. 2, 2008From: Springer Protocols
    edited by Elizabeth Vincan.
    v. 1. Pathway methods and mammalian models -- v. 2. Pathway models.
  • 2012From: Springer Protocols
    edited by Allan V. Kalueff, Adam Michael Stewart.
    Measuring larval Zebrafish behavior : locomotion, thigmotaxis, and startle / William H.J. Norton -- Light-dark preference test for larval Zebrafish / Peter J. Steenbergen, Michael K. Richardson, and Danielle L. Champagne -- Assessment of thigmotaxis in larval Zebrafish / Stephanie J. Schnorr [and others] -- Zebrafish and drug development : a behavioral assay system for probing nicotine function in larval Zebrafish / Henning Schneider [and others] -- Olfactory-evoked activity assay for larval Zebrafish / Ganive Bhinder and Keith B. Tierney -- Qualitative and quantitative measurements of the optokinetic response in larval Zebrafish / Kaspar P. Mueller and Stephan C.F. Neuhauss -- Automated imaging of visual recognition memory in larval Zebrafish / Ruth M. Colwill and Robbert Creton -- Automated conditioning in larval Zebrafish / Ruey-Kuang Cheng and Suresh Jesuthasan -- Methods to quantify basal and stress-induced cortisol response in larval Zebrafish / Peter J. Steenbergen [and others] -- Method for sorting Zebrafish on the exploratory-bold behavioral axis / Cory D. Sailer, Sonny J. Radenic, and Brian D. Wisenden -- Nocifensive behavior in adult and larval Zebrafish / Monica Gomes Lima [and others] -- Use of a split depth and visual cliff apparatus to measure the diving response in Zebrafish / Rachel Blaser and Kelly Goldsteinholm -- Adapting the open field test to assess anxiety-related behavior in Zebrafish / John Godwin [and others] -- Behavioral and pharmacological aspects of anxiety in the light/dark preference test / Juliana Araujo [and others] -- High-throughput and inexpensive assay for anxiety-related behaviors in the Zebrafish, based on place preference and latency to feed / Barrie D. Robison [and others] -- Automated Tracking of Zebrafish shoals and the analysis of shoaling behavior / Noam Miller and Robert Gerlai -- Assessing social behavior phenotypes in adult Zebrafish : shoaling, social preference, and mirror biting tests / Mimi Pham [and others] -- Measuring effects of psychostimulants on egocentric spatial learning and memory in adult Zebrafish / Rabia Nasir [and others] -- Cued fear conditioning in Zebrafish (Danio rerio) / Masakazu Agetsuma [and others] -- Assessing learning and memory through the active avoidance paradigm / Xiaojuan Xu and Stefan Goetz -- Assessing habituation phenotypes in adult Zebrafish : intra- and inter-trial habituation in the novel tank test / Jolia Raymond [and others] -- Assessing startle responses and their habituation in adult Zebrafish / Simon Chanin [and others] -- QTL mapping using behavioral traits in the adult Zebrafish / Dominic Wright -- Assessing epilepsy-related behavioral phenotypes in adult Zebrafish / Daniel Desmond [and others] -- Rapid method for acute intracerebroventricular injection in adult Zebrafish / Augusto Barbosa Junior [and others] -- Western blotting assay for Egr-1 immediate early gene in brain tissue of Zebrafish applied to neuroethological study / Augusto Barbosa Junior [and others] -- Utilizing the Zebrafish neurophenome project (ZNP) database for analyses of complex neurophenotypes in Zebrafish models / Ivan Zapolsky [and others].
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