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  • Clinical cases selected from the LANGE Case Files series, edited by Eugene C. Toy, MD.
  • 1. Adipocyte Precursors: Developmental Origins, Self-Renewal, and Plasticity / Christian Dani and Nathalie Billon -- 2. Adipocyte Differentiation / José María Moreno-Navarrete and José Manuel Fernández-Real -- 3. Brown Adipose Tissue / Martin Klingenspor and Tobias Fromme -- 4. White Adipose Tissue / Stephane Gesta and C. Ronald Kahn -- 5. Sex Differences in Body Fat Distribution / Alain Veilleux and André Tchernof -- 6. Macrophages and Inflammation / Elise Dalmas, Joan Tordjman, Michèle Guerre-Millo, and Karine Clément -- 7. Adipocyte Growth and Factors Influencing Adipocyte Life Cycle / Srujana Rayalam and Clifton A. Baile -- 8. The Evolution of Mammalian Adipose Tissue / Caroline M. Pond -- 9. Dietary Determinants of Fat Mass and Body Composition / María A. Zulet, María J. Moreno-Aliaga, and J. Alfredo Martínez -- 10. The Genetic Determinants of Common Obesity-Susceptibility / Ruth J.F. Loos -- 11. Early Origins of Obesity and Developmental Regulation of Adiposity / Shalini Ojha and Helen Budge.
  • Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. You can also access the complete contents online at Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more.
  • This book contains the Proceedings of the 3rd International Conference on Cognitive Neurodynamics held in Japan, June 9-13, 2011. It reviews the progress in this field since the first ICCN in 2007. The participants were treated to an exciting and stimulating conference that left everyone with an enthusiastic vision for the future. The discussed topics in this book include: Neural coding and realistic neural network dynamics, Neural population dynamics, Firing Oscillations and Patterns in Neuronal Networks, Brain imaging, EEG, MEG, Sensory and Motor Dynamics, Global cognitive function, Multi-scalar Neurodynamics - from Physiology to Systems Theory, Neural computing, Emerging Technologies for Brain Computer Interfaces, Neural dynamics of brain disorders.
  • Introduction to the theory of aging networks / Witten, T.M. -- Applications to aging networks / Wimble, C., Witten, T.M. -- Computational systems biology for aging research / Auley, M.T., Mooney, K.M. -- How does the body know how old it is? Introducing the epigenetic clock hypothesis / Mitteldorf, J. -- The great evolutionary divide : two genomic systems biologies of aging / Rose, M.R., Cabral, I.G., Philips, M.A., Rutledge, G.A., Phung, K.H., Mueller, L.D., Greer, L.F. -- Development and aging : two opposite but complementary phenomena / Feltes, B.C., De Faria Poloni, J., Bonatto, D. -- Aging as a process of deficit accumulation : its utility and origin / Mitnitski, A., Rockwood, K. -- Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease / Guarner, V., Rubio-Ruiz, M.E. -- Modulating mTOR in aging and health / Johnson, S.C., Sangesland, M., Kaeberlein, M., Rabinovitch, P. -- Melatonin and circadian oscillators in aging : a dynamic approach to the multiply connected players / Hardeland, R. -- Diet-microbiota-health interactions in older subjects : implications for healthy aging / Lynch, D.B., Jeffery, I.B., Cusack, S., O'Connor, E.M., O'Toole, P.W. -- Systems biology approaches in aging research / Chauhan, A., Liebal, U.W., Vera, J., Baltrusch, S., Junghanss, C., Tiedge, M., Fuellen, G., Wolkenhauer, O., Köhling, R. -- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention : do we really have an antiaging drug? / Anisimov, V.N.
  • Appetite control 2012
    The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control.
  • A tribute to Professor Autar Singh Paintal -- Structure of chemoreceptors -- Developmental aspects of chemoreceptors -- Molecular biology of chemoreceptors -- Biophysics of ionic channels in chemoreceptors -- Central integration and systemic effects of chemoreflex -- Mechanisms of chemoreceptions.
  • Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
  • Atlas of breast surgery 2015
  • Part 1. Part I. -- Introduction and Applications of Surface EMG -- Basic Concepts Concerning Fields and Potential Distributions of Stationary and Moving Point Sources -- Generation, Propagation, and Extinction of Single-Fiber and Motor Unit Action Potentials -- EMG Imaging: Geometry and Anatomy of the Electrode-Muscle System -- Features of the Single-Channel sEMG Signal -- Features of the Two-Dimensional sEMG Signal: EMG Feature Imaging -- Applications of sEMG in Dynamic Conditions, Ergonomics, Sports, and Obstetrics -- Part 2. Part II. -- Trunk -- Upper Limb -- Lower Limb.
  • Peripheral processing -- Mosaic evolution of the mammalian auditory periphery -- A computer model of the auditory periphery and its application to the study of hearing -- A probabilistic account of absolute auditory thresholds and its possible physiological basis -- Cochlear compression: Recent insights from behavioural experiments -- Improved psychophysical methods to estimate peripheral gain and compression -- Contralateral efferent regulation of human cochlear tuning: Behavioural observations and computer model simulations -- Modeling effects of precursor duration on behavioral estimates of cochlear gain -- Is overshoot caused by an efferent reduction in cochlear gain? -- Accurate estimation of compression in simultaneous masking enables the simulation of hearing impairment for normal-hearing listeners -- Modelling the distortion produced by cochlear compression -- Temporal fine structure and pitch -- How independent are the pitch and the interaural-time-difference mechanisms that rely on temporal fine structure information? -- On the limit of neural phase-locking to fine-structure in humans -- Effects of sensorineural hearing loss on temporal coding of harmonic and inharmonic tone complexes in the auditory nerve -- A glimpsing account of the role of temporal fine structure information in speech recognition -- Assessing the possible role of frequency-shift detectors in the ability to hear out partials in complex tones -- Pitch perception: Dissociating frequency from fundamental-frequency discrimination -- Pitch perception for sequences of impulse responses whose scaling alternates at every cycle -- Putting the tritone paradox into context: insights from neural population decoding and human psychophysics -- Enhancement and perceptual compensation -- Spectral and level effects in auditory enhancement -- Enhancement of increments in spectral amplitude: further evidence for a mechanism based on central adaptation -- Differential sensitivity to appearing and disappearing objects in complex acoustic scenes -- Perceptual compensation when isolated test words are heard in room reverberation -- A new approach to sound source identification -- Binaural processing -- Maps of ITD in the Nucleus Laminaris of the Barn Owl -- The influence of the envelope waveform on binaural tuning of neurons in the inferior colliculus and its relation to binaural perception -- No evidence for ITD-specific adaptation in the frequency following response -- Interaural time difference thresholds as a function of frequency -- Interaural time processing when stimulus bandwidth differs at the two ears -- Neural correlates of the perception of sound source separation -- When and how envelope "rate-limitations" affect processing of interaural temporal disparities conveyed by high-frequency stimuli -- The sound source distance dependence of the acoustical cues to location and their encoding by neurons in the inferior colliculus: implications for the Duplex theory -- Cochlear contributions to the precedence effect -- Off-frequency BMLD: the role of monaural processing -- Measuring the apparent width of auditory sources in normal and impaired hearing -- Psychophysics of human echolocation -- Speech and temporal processing -- Formant-frequency variation and its effects on across-formant grouping in speech perception -- Do we need STRFs for cocktail parties? - On the relevance of physiologically motivated features for human speech perception derived from automatic speech recognition -- Modeling speech intelligibility in adverse conditions -- Better temporal neural coding with cochlear implants in awake animals -- Effects of auditory nerve refractoriness and adaptation on auditory perception -- Robust cortical encoding of slow temporal modulations of speech -- Wideband monaural envelope correlation perception -- Detection thresholds for amplitude modulations of tones in budgerigar (Melopsittacus undulatus) -- Phase discrimination ability in Mongolian gerbils provides evidence for possible processing mechanism of mistuning detection -- Auditory cortex and beyond -- Stimulus-specific adaptation beyond pure tones -- Mapping tonotopy in human auditory cortex -- Cortical activity associated with the perception of temporal asymmetry in ramped and damped noises -- Cortical representation of the combination of monaural and binaural unmasking -- Processing of short auditory stimuli: The Rapid Audio Sequential Presentation paradigm (RASP) -- Integration of auditory and tactile inputs in musical meter perception -- A dynamic system for the analysis of the acoustic features and valence of aversive sounds in the human brain -- Auditory scene analysis -- Can comodulation masking release occur when frequency changes would promote perceptual segregation of the on-frequency and flanking bands? -- Illusory auditory continuity despite neural evidence to the contrary -- High-acuity spatial stream segregation -- How early aging and environment interact in everyday listening: From brainstem to behaviour through modeling -- Energetic and informational masking in a simulated restaurant environment -- A computational model for the dynamic aspects of primitive auditory scene analysis -- A naturalistic approach to the cocktail party -- Temporal coherence and the streaming of complex sounds.
  • Introduction -- Understanding Accreditation and Certification in Musculoskeletal Ultrasound -- Choosing Ultrasound Equipment -- Knobology -- Tissue Scanning -- Hand and Fingers -- Wrist -- Elbow -- Shoulder -- Foot and Toes -- Ankle -- Knee -- Hip -- Groin -- Ultrasound Guidance of Injections -- Rheumatologic Findings.
  • Principles of cell function -- Homeostasis of body fluids -- Signal transduction, membrane receptors, second messengers, and regulation of gene expression -- The nervous system: introduction to cells and systems -- Generation and conduction of action potentials -- Synaptic transmission -- The somatosensory system -- The special senses -- Organization of motor function -- Higher functions of the nervous system -- The autonomic nervous system and its central control -- Sketetal muscle physiology -- Cardiac muscle -- Smooth muscle -- Overview of circulation -- Elements of cardiac function -- Properties of the vasculature -- Regulaiton of the heart and vasculature -- Integrated control of the cardiovascular system -- Structure and function of the respiratory system -- Mechanical properties of the lung and chest wall: static and dynamic -- Ventilation (V̇), perfusion (Q̇), and V̇/Q̇ relationships -- Oxygen and carbon dioxide transport -- Control of respiration -- Nonrespiratory functions of the lung -- Functional anatomy and general principles of regulation in the gastrointestinal tract -- The cephalic, oral, and esophageal phases of the integrated response to a meal -- The gastric phase of the integrated response to a meal -- The small intestinal phase of the integrated response to a meal -- The colonic phase of the integrated response to a meal -- Transport and metabolic functions of the liver -- Elements of renal function -- Solute and water transport along the nephron: tubular function -- Control of body fluid osmolality and volume -- Potassium, calcium, and phosphate homeostasis -- Role of the kidneys in the regulation of acid-base balance -- Introduction to the endocrine system -- Hormonal regulation of energy metabolism -- Hormonal regulation of calcium and phosphate metabolism -- The hypothalamus and pituitary gland -- The thyroid gland -- The adrenal glands -- The male and female reproductive systems.
  • "Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. eyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease (SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment"--Publisher's description.
  • Mechanics of hard tissue / J. Lawrence Katz -- Musculoskeletal soft tissue mechanics / Richard L. Lieber, Thomas J. Burkholder -- Joint-articulating surface motion / Kenton R. Kaufman, Kai-Nan An -- Joint lubrication / Michael J. Furey -- Analysis of gait / Roy B. Davis, III, Sylvia Ounpuu, Peter A. DeLuca -- Mechanics of head/neck / Albert I. King, David C. Viano -- Biomechanics of chest and abdomen impact / David C. Viano, Albert I. King -- Cardiac biomechanics / Andrew D. McCulloch -- Heart valve dynamics / Ajit P. Yoganathan, Jack D. Lemmon, Jeffrey T. Ellis -- Arterial macrocirculatory hemodynamics / Baruch B. Lieber -- Mechanics of blood vessels / Thomas R. Canfield, Philip B. Dobrin -- The venous system / Artin A. Shoukas, Carl F. Rothe -- Mechanics, molecular transport, and regulation in the microcirculation / Aleksander S. Popel, Roland N. Pittman -- Mechanics and deformability of hematocytes / Richard E. Waugh, Robert M. Hochmuth -- Mechanics of tissue/lymphatic transport / Geert W. Schmid-Schonbein, Alan R. Hargens -- Modeling in cellular biomechanics / Alexander A. Spector, Roger Tran-Son-Tay -- Cochlear mechanics / Charles R. Steele ... [et al.] -- Vestibular mechanics / Wallace Grant -- Exercise physiology / Arthur T. Johnson, Cathryn R. Dooly -- Factors affecting mechanical work in humans / Ben F. Hurley, Arthur T. Johnson.
  • Contribution of adipose tissue to health span and longevity / Huffman, D.M., Barzilai, N. -- Obesity paradox during aging / Chapman, I.M. -- Central control of food intake in aging / Kmiec, Z. -- Changes in food intake and its relationship to weight loss during advanced age / McDonald, R.B., Ruhe, R.C. -- Changes in body composition in response to challenges during aging in rats / Wolden-Hanson, T. -- New haystacks reveal new needles : using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging / Wolkow, C.A. -- Sarcopenia : prevalence, mechanisms, and functional consequences / Berger, M.J., Doherty, T.J. -- mTOR signaling as a target of amino acid treatment of the age-related sarcopenia / D'Antona, G., Nisoli, E. -- Mitochondrial theory of aging in human age-related sarcopenia / Parise, G., De Lisio, M. -- Exercise as a calorie restriction mimetic : implications for improving healthy aging and longevity / Huffman, D.M. -- Clinical, cellular and molecular phenotypes of aging bone / Syed, F.A. ... [et al.].
  • The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice.The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.
  • "Save time identifying and diagnosing pathology specimens with High Yield Bone and Soft Tissue Pathology, edited by Drs. Andrew Horvai and Thomas Link. Part of the High-Yield Pathology Series, this title is designed to help you review the key pathologic features of bone and soft-tissue malformations, recognize the classic look of each disease, and quickly confirm your diagnosis. Its templated format, excellent color photographs, concise bulleted text, and authoritative content will help you accurately identify more than 160 discrete disease entities. Online access to complete text, image bank, and more at makes this an ideal reference for on-the-go pathologists."--Publisher's website.
  • An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come.
  • Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells / Lin Mei, Yun-Min Zheng, and Yong-Xiao Wang -- Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter / Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, and Jennifer M. Haick -- Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells / Jun-Hua Xiao, Yong-Xiao Wang, and Yun-Min Zheng -- Large-conductance calcium-activated potassium channels / Hiroaki Kume -- Calcium-activated Chloride Channels / George Gallos and Charles W. Emala Sr. -- Local Calcium Signaling in Airway Smooth Muscle Cells / Quing-Hua Liu, Carlo Savoia, Yong-Xiao Wang -- Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices / Michael J. Sanderson -- Temporal Aspects of Ca2+ Signaling in Airway Myocytes / Etienne Roux -- Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle / Charlotte K. Billington, Ian P. Hall, and Carl P. Nelson -- Novel Mechanisms in Ca2+-homeostasis and Internal Store Refilling of Airway Smooth Muscle / Luke J. Janssen -- The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle / Philippe Delmotte, Li Jia, and Gary C. Sieck -- Role of Caveolae in the Airway / Christina M. Pabelick, Brij B. Singh, and Y.S. Prakash -- CD38 : Cyclic ADP-ribose-mediated Calcium Signaling in Airway Myocytes /Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, and Mathur S. Kannan -- The Pathways and Signaling Cross-talk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells / Lei Cai and Quinghua Hu -- Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions / Satoru Ito -- Role of Integrins in the Regulation of Calcium Signaling / Thai Tran and Chun Ming Teoh -- Sex Steroid Signaling in the Airway / Y.S. Prakash, Venkatachalem Sathish, and Elizabeth A. Townsend -- Regulation of Contractility in Immature Airway Smooth Muscle / Y.S. Prakash, Christina M. Pabelick, and Richard J. Martin -- Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells / James Sneyd, Pengxing Cao, Xiahui Tan, and Michael J. Sanderson -- Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells / Hisako Matsumoto -- Ca2+ Signaling and P2 Receptors in Airway Smooth Muscle / Luis M. Montaño, Edgar Flores-Soto, and Carlos Barajas-López -- Calcium Signaling in Airway Smooth Muscle Remodeling / Tengyao Song, Yun-min Zheng, and Yong-Xiao Wang -- Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle / Deepak A. Deshpande and Stephen B. Liggett -- Modulation of Airway Smooth Muscle Contractile Function by TNFa and IL-13 and Airway Hyper-responsiveness in Asthma / Yassine Amrani -- Airway Smooth Muscle Malfunction in COPD / Yunchao Su.
  • Summary -- Introduction -- Direct evidence - the digital approach -- Fluorescence-based visualisation -- Aequorin-based measurements -- Measurement of calcium transport across membranes -- Molecular biology based approaches -- Manipulation of calcium -- Calcium-induced function -- Calcium signalling in cardiac myocytes -- Calcium signalling in red blood cells -- Perspective -- Calcium Signalling Methodology -- Non-linear and ultra high-speed imaging for explorations of the murine and human heart -- A system for optical high resolution screening of electrical excitable cells -- Concepts for optical high content screens of excitable primary isolated cells -- A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes -- Calcium imaging of individual erythrocytes: Problems and approaches -- Calcium Signalling in Cardiac Myocytes -- Reduced Cardiac L-Type Ca²+ Current in Cav€ ₂ -/- Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation -- Overexpression of junctin causes adaptive changes in cardiac myocyte Ca²+ signaling -- Remodelling of Ca²+ handling organelles in adult rat ventricular myocytes during longterm culture -- Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement -- Calcium Signalling in Red Blood Cells -- The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation -- Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance -- Prostaglandin E₂ activates channelmediated calcium entry in human erythrocytes: An indication for a blood clot formation supporting process -- Functional NMDA receptors in rat erythrocytes -- Stimulation of human red blood cells leads to Ca²+-mediated intercellular adhesion -- Lysophospatidic acid induced red blood cell aggregation in vitro -- Regulation of phosphatidylserine exposure in red blood cells -- Cation Channels in Erythrocytes - Historical and Future Perspective.
  • The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to [alpha]-adrenoceptor and [beta]-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
  • The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
  • Overview of the respiratory system / S.C. Wood -- Control of respiration in aquatic vertebrates: Gas transport and gill function in water-breathing fish / S.F. Perry ... [et al.]. Patterns of acid-base regulation during exposure to hypercarbia in fishes / C.J. Brauner and D.W. Baker. Buoyancy control in aquatic vertebrates / B. Pelster. Gas exchange and control of respiration in air-breathing teleost fish / M.L. Glass and F.T. Rantin. Effects of temperature on cardiac function in teleost fish / A.L. Kalinin ... [et al.]. Physiological evidence indicates lungfish as a sister group to the land vertebrates / M.L. Glass. Aestivation in amphibians, reptiles, and lungfish / M.L. Glass, J. Amin-Naves, and G.S.F. da Silva -- Evolution of pulmonary mechaincs and respiratory control: Trade-offs in the evolution of the respiratory apparatus of chordates / S.F. Perry, W. Klein, and J.R. Codd. Environmental selection pressures shaping the pulmonary surfactant system of adult and developing lungs / S. Orgeig and C.B. Daniels. Midbrain structures and control of ventilation in amphibians / L.H. Gargaglioni and L.G.S. Branco. Comparative aspects of hypoxia tolerance of the ectothermic vertebrate heart / H. Gesser and J. Overgaard. Control of the heart and of cardiorespiratory interactions in ectothermic vertebrates / E.W. Taylor and T. Wang. The endocrine-paracrine control of the cardiovascular system / B. Tota and M.C. Cerra. Stoking the brightest fires of life among vertebrates / Raul K. Suarez and Kenneth C. Welch -- Respiratory physiology of birds : metabolic control: Prenatal development of cardiovascular regulation in avian species / J. Altimiras, D.A. Crossley II, and E. Villamor. Control of breathing in birds : implications for high-altitude flight / G.R. Scott and W.K. Milsom -- Mammalian and human physiology: Peripheral chemoreceptors in mammals : structure, function and transduction / P. Kumar. Central chemosensitivity in mammals / L.K. Hartzler and R.W. Putnam. Human exercise physiology / S. Volianitis and Niels H. Secher.
  • Print Material
  • Overview of the cardiovascular system -- Characteristics of cardiac muscle cells -- The heart pump -- Measurements of cardiac function -- Cardiac abnormalities -- The peripheral vascular system -- Vascular control -- Hemodynamic interactions -- Regulation of arterial pressure -- Cardiovascular responses to physiological stresses -- Cardiovascular function in pathological situations -- Answers to study questions.
  • "Today's knowledge of human health demands a multidisciplinary understanding of medically related sciences, and Case Studies in the Physiology of Nutrition answers the call. Dedicated to the integration of nutrition science with physiology, this text cohesively incorporates descriptions of human problems in order to stimulate students' critical thinking about how the body integrates various physiological factors to maintain homeostasis. This textbook uses short story-type case studies about fictional individuals who have health problems in order to address a range of issues in an approachable manner. The studies vary in difficulty, with some being straightforward with very simple answers, while others require in-depth thinking and literature research to solve. Each study presents patient background, symptoms, clinical finding, and questions to ponder. Upon qualifying course adoption, this book also includes a valuable instructor's manual, which provides solutions to exercises, problem analysis, and resolution to each case study."--Publisher's description.
  • Cat primary visual cortex 2002
    The concept of cat primary visual cortex / Bertram R. Payne and Alan Peters -- Optical imaging of functional architecture in cat primary visual cortex / Mark Hubener and Tobias Bonhoeffer -- 2-Deoxyglucose architecture of cat primary visual cortex / Siegrid Lowel -- Functional mapping in the cat primary visual cortex using high magnetic fields / Dae-Shik Kim, Timothy Q. Duong, Kamil Ugurbil, and Seong-Gi Kim -- Relationships of LGN afferents and cortical efferents to cytochrome oxidase blobs / Joanne A. Matsubara and Jamie D. Boyd -- Influence of topography and ocular dominance on the functional organization of callosal connections in cat striate cortex / Jaime F. Olavarria -- Essential and sustaining LGN inputs to cat primary visual cortex / Theodore G. Weyand -- Integration of thalmic inputs to cat primary visual cortex / R. Clay Reid, Jose-Manuel Alonso, and W. Martin Usrey -- The emergence of direction selectivity in cat primary visual cortex / Allen L. Humphrey and Alan B. Saul -- Long-range intrinsic connections in cat primary visual cortex / Kerstin E. Schmidt and Siegrid Lowell -- Pharmacological studies on receptive field architecture / Ulf T. Eysel -- Orientation selectivity and its modulation by local and long-range connections in visual cortex / David Somers, Valentin Dragoi, and Mriganka Sur -- Response synchronization, gamma oscillations, and perceptual binding in cat primary visual cortex / Wolf Singer -- The special relationship between B Retinal ganglion cells and cat primary visual cortex / Bertram R. Payne and R. Jarrett Rushmore -- Primary visual cortex within the cortico-cortico-thalmic network / Jack W. Scannell and Malcolm P. Young -- Behavioral analyses of the contributions of cat primary visual cortex to vision / Donald E. Mitchell -- Index.
  • 1. Human Evolution and Physical Exercise: The Concept of Being "Born to Run" / Livio Luzi -- 2. Cell Morphology and Function: The Specificities of Muscle Cells / Anna Maestroni -- 3. The Cell Membrane of the Contractile Unit / Gianpaolo Zerbini -- 4. Gene Polymorphisms and Athletic Performance / Ileana Terruzzi -- 5. Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise / Stefano Benedini -- 6. Mitochondrial and Non-mitochondrial Studies of ATP Synthesis / Roberto Codella -- 7. Excessive Nutrients and Regional Energy Metabolism / Gianluca Perseghin -- 8. Muscle Biopsy To Investigate Mitochondrial Turnover / Rocco Barazzoni -- 9. Introduction to the Tracer-Based Study of Metabolism In Vivo / Andrea Caumo and Livio Luzi -- 10. Physical Activity and Inflammation / Raffaele Di Fenza and Paolo Fiorina -- 11. The HPA Axis and the Regulation of Energy Balance / Francesca Frigerio -- 12. Physical Exercise in Obesity and Anorexia Nervosa / Alberto Battezzati and Simona Bertoli -- 13. Physical Exercise and Transplantation / Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi -- 14. The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise / Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.
  • Introduction : homeostasis and cellular physiology -- Diffusion and permeability -- Osmotic pressure and water movement -- Electrical consequences of ionic gradients -- Ion channels -- Passive electrical properties of membranes -- Generation and propagation of the action potential -- Ion channel diversity -- Electrochemical potential energy and transport processes -- Passive solute transport -- Active transport -- Synaptic physiology I -- Synaptic physiology II -- Molecular motors and the mechanism of muscle contraction -- Excitation-contraction coupling in muscle -- Mechanics of muscle contraction.
  • Section 1 Historical Introduction to Secreted Cell Stress Proteins as Signalling Proteins -- Discovery of the Cellular Secretion of Cell Stress Proteins -- Discovery of the Agonist Activities of Molecular Chaperones and Protein-Folding Catalysts -- Identification of Cell Stress Proteins in Biological Fluids -- Section 2 Intracellular Trafficking of Molecular Chaperones and its Consequences -- Hsp27 Phosphorylation Patterns and Cellular Consequences -- Evidence on Cholesterol-Controlled Lipid Raft Interaction of the Small Heat Shock Protein HSPB11 -- Hsp70 Chaperone Systems in Vesicular Trafficking -- Pathways of Hsp70 Release: Lessons from Cytokine Secretion -- Nucleolin: A Novel Intracellular Transporter of HSPA1A -- The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control -- Section 3 Molecular Chaperones as Cell Surface Receptors and Receptor Ligands -- Cell Surface Molecular Chaperones and the LPS Receptor -- Hsp60: An Unexpected Cell Surface Receptor in Prokaryotes and Eukaryotes -- Pathophysiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)-based Macromolecules and Nanotherapeutics to Solid Tumors -- The Chaperokine Activity of HSPA1A -- Molecular Chaperones and Scavenger Receptors: Binding and Trafficking of Molecular Chaperones by Class F and Class H Scavenger Receptors -- Grp78 (BiP): A Multifunctional Cell Surface Receptor -- Section 4 Extracellular Secretion of Molecular Chaperones in Prokaryotes and Eukaryotes -- Mycobacterium Tuberculosis Hsp60 as a Key Virulence Factor in Tuberculosis -- Hsp90 vs Conventional Growth Factors in Acute and Diabetic Wound Healing -- Circulating Molecular Chaperones in Health and Disease -- Index.
  • Cerebellar learning 2014
    Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biologi
  • This book represents the first in a two-volume set on biological rhythms. This volume focuses on supporting the claim that biological rhythms are universal and essential characteristics of living organisms, critical for proper functioning of any living system. The author begins by examining the potential reasons for the evolution of biological rhythms: (1) the need for complex, goal-oriented devices to control the timing of their activities; (2) the inherent tendency of feedback control systems to oscillate; and (3) the existence of stable and powerful geophysical cycles to which all organisms must adapt. To investigate the second reason, the author enlists the help of biomedical engineering students to develop mathematical models of various biological systems. One such model involves a typical endocrine feedback system. By adjusting various model parameters, it was found that creating a oscillation in any component of the model generated a rhythmic cascade that made the entire system oscillate. This same approach was used to show how daily light/dark cycles could cascade rhythmic patterns throughout ecosystems and within organisms.
  • Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as 'antennae' for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
  • Circadian rhythms 2005
    Genetic approaches to circadian clocks -- Tracking circadian control of gene activity -- Molecular cycles : clock protein rhythms -- Anatomical representation of neural clocks -- Mosaic circadian systems -- Peripheral circadian clocks -- Cell and tissue culture system -- Intercellular signaling -- Photoresponsive clocks -- Sleeping flies -- Circadian biology of populations -- Circadian clocks affecting noncircadian biology.
  • Clinical Application of Neuromuscular Techniques, Volume 2 - The Lower Body discusses the theory and practice of the manual treatment of chronic pain, especially with regards to the soft tissues of the lower body.
  • Print Material
    Anatomy and physiology -- Electronics and instrumentation -- Nerve conduction studies and electromyography (EMG) -- Electroencephalography (EEG) -- Evoked potentials and intraoperative monitoring (IOM) -- Polysomnography and other sleep studies (PSG) -- Advanced topics : high frequency oscillations (HFOs), DC shifts, transcranial electrical stimulation (TES), motor evoked potential (MEP), transcranial magnetic stimulation (TMS), magnetoencephalopgraphy (MEG), autonomic testing, blink reflex, single fiber EMG (SFEMG), quantitative EEG (QEEG) -- Ethics and safety.
  • The mainstay of orthopedic diagnosis continues to be the physical examination of the patient following a thorough history. This convenient pocketbook presents a comprehensive collection of the clinical tests that are used in orthopedic diagnosis, thereby answering the following questions: What tests are available for examining a particular joint, and how are they to be interpreted? What is meant by the name of a test that is mentioned in the literature or in a physician's report? The methodology and interpretation of all relevant test procedures are presented in almost 500 instructive drawings and brief descriptions: Initial tests, Functional tests, Stress tests, Stability tests. Tables on the examination of the spinal column, shoulder joint, and knee joint help in selecting the most suitable examinations. An invaluable aid for physical therapists, orthopedic surgeons, and primary care or emergency room physicians.
  • Clocks and rhythms 2007
    Cold Spring Harb Lab Press
    Introduction -- Clockworks -- Posttranscriptional and posttranslational mechanisms -- Genetics of rhythms -- Entrainment and peripheral clocks -- Systems approaches to biological clocks -- Models -- Development, proliferation, and aging -- Neuroanatomy and circuits -- Sleep, seasons, and mood.
  • The body -- The Cell -- Tissues -- General features of the skeleton -- General features of the muscles -- Anatomical terms and their Latin equivalents -- Trunk -- Anatomical terms and their Latin equivalents -- Upper Limb -- Bones, ligaments and joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Lower Limb -- Bones, ligaments, joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Head and Neck -- Skull -- Muscles and fascias -- Anatomical terms and their Latin equivalents -- Topography of peripheral nerves and vessels -- Head and neck -- Upper limb -- Trunk -- Lower limb -- Anatomical terms and their Latin equivalents.
  • Fundamentals -- Temperature, energy -- Blood -- Respiration, acid-base balance -- Kidney, salt and water balance -- Stomach, intestines, liver -- Heart and circulation -- Metabolism -- Hormones -- Neuromuscular and sensory systems.
  • Print Material
    Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
  • Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
  • Introduction : the broad horizons of comparative genomics / James R. Brown -- Advances in next-generation DNA sequencing technologies / Michael L. Metzker -- Large scale phylogenetic reconstruction / Bernard M.E. Moret -- Comparative genomics of viruses using bioinformatics tools / Chris Upton and Elliot J. Lefkowitz -- Archaebacteria and the prokaryote-to-eukaryote transition (and the role of mitochondria therein) / William Martin, Tal Dagan, and Katrin Henze -- Comparative genomics of invertebrates / Takeshi Kawashima ... [et al.] -- Comparative vertebrate genomics / James W. Thomas -- Gaining insight into human population-specific selection pressure / Michael R. Barnes -- Comparative genomics in drug discovery / James R. Brown -- Comparative genomics and the development of novel antimicrobials / Diarmaid Hughes -- Comparative genomics and the development of antimalarial and antiparasitic therapeutics / Emilio F. Merino, Steven A. Sullivan, and Jane M. Carlton -- Comparative genomics in AIDS research / Philippe Lemey, Koen Deforche, and Anne-Mieke Vandamme -- Detailed comparisons of cancer genomes / Timon P.H. Buys ... [et al.] -- Comparative cancer epigenomics / Alice N.C. Kuo ... [et al.] -- G protein-coupled receptors and comparative genomics / Steven M. Foord -- Comparative toxicogenomics in mechanistic and predictive toxicology / Joshua C. Kwekel, Lyle D. Burgoon, and Tim R. Zacharewski -- Comparative genomics and crop improvement / Michael Francki and Rudi Appels -- Domestic animals : a treasure trove for comparative genomics / Leif Andersson.
  • This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
  • An introduction to fasting, starvation, and food limitation / Marshall D. McCue -- A history of modern research into fasting, starvation, and inanition / Jean-Hervé Lignot and Yvon LeMaho -- Starvation in rotifers : physiology in an ecological context / Kevin L. Kirk -- Drosophila as a model for starvation : evolution, physiology, and genetics / Alen G. Gibbs and Lauren A. Reynolds -- Metabolic transitions during feast and famine in spiders / Johannes Overgaard and Tobias Wang -- Adaptation of the physiological, endocrine, and digestive system functions to prolonged food deprivation in fish / Nadav Bar and Helene Volkoff -- Starvation in subterranean species versus surface-dwelling species : crustaceans, fish, and salamanders / Frédéric Hervant -- Physiological responses to starvation in snakes : low energy specialists / Marshall D. McCue, Harvey B. Lillywhite, and Steven J. Beaupre -- Cardiovascular circuits and digestive function of intermittent-feeding sauropsids / Rike Campen and Matthias Starck -- Thermoregulatory adaptations to starvation in birds / Esa Hohtola -- Fasting in birds : general patterns and the special case of endurance flight / Susanne Jenni-Eiermann and Lukas Jenni -- Tissue-specific mass changes during fasting : the protein turnover hypothesis / Ulf Bauchinger and Scott R. McWilliams -- Seasonal changes in body mass and energy balance in wild small mammals / Xueying Zhang, Xinyu Liu, and Dehua Wang -- Changes in form and function of the gastrointestinal tract during starvation : from pythons to rats / Jehan-Hervé Lignot -- Changes in fatty acid composition during starvation in vertebrates : mechanisms and questions / Edwin R. Price and Teresa G. Valencak -- Physiological responses to fasting in bats / Miriam Ben-Hamo, Agustí Muñoz-Garcia, and Berry Pinshow -- Muscle protein and strength retention by bears during winter fasting and starvation / Hank Harlow -- Seasonal starvation in northern white-tailed deer / Duane E. Ullrey -- Fasting physiology of the pinnipeds : the challenges of fasting while maintaining high energy expenditure and nutrient delivery for lactation / Cory D. Champagne ... [et al.] -- The use and application of stable isotope analysis to the study of starvation, fasting, and nutritional stress in animals / Kent A. Hatch -- Fearing the danger point : the study and treatment of human starvation in the United Kingdom and India, c. 1880-1974 / Kevin Grant -- Quantitative physiology of human starvation : adaptations of energy expenditure, macronutrient metabolism, and body composition / Kevin D. Hall -- Alternate day fasting : effects on body weight and chronic disease risk in humans and animals / Krista A. Varady -- Horizons in starvation research/ Marshall D. McCue.
  • Connected hippocampus 2015
    1. If I had a million neurons: potential tests of cortico-hippocampal theories -- 2. Diluted connectivity in pattern association networks facilitates the recall of information from the hippocampus to the neocortex -- 3. Cortico-hippocampal systems involved in memory and cognition: the PMAT framework -- 4. The subiculum: the heart of the extended hippocampal system -- 5. The neural correlates of navigation beyond the hippocampus -- 6. Septo-hippocampal signal processing: breaking the code -- 7. Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function -- 8. Importance of the ventral midline thalmas in driving hippocampal functions -- 9. The mammillary bodies and memory: more than a hippocampal relay -- 10. Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions -- 11. Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding -- Index.
  • The study and modulation of cortical connections is a rapidly growing area in neuroscience. This unique book by prominent researchers in the field covers recent advances in this area. The first section of the book describes studies of cortical connections, modulation of cortical connectivity and changes in cortical connections with activities such as motor learning and grasping in primates. The second section covers the use of non-invasive brain stimulation to study and modulate cortical connectivity in humans. The last section describes changes in brain connectivity in neurological and psychiatric diseases, and potential new treatments that manipulate brain connectivity. This book provides an up-to-date view of the study of cortical connectivity, and covers its role in both fundamental neuroscience and potential clinical applications.
  • Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereotype.This book is the most comprehensive reference to date on craniofacial muscle development, structure, function, and disease. It details the state-of-the-art basic science of the craniofacial muscles, and describes their unique response to major neuromuscular conditions. Most importantly, the text highlights how the craniofacial muscles are different from most skeletal muscles, and why they have been viewed as a distinct allotype. In addition, the text points to major gaps in our knowledge about these very important skeletal muscles and identified key gaps in our knowledge and areas primed for further study and discovery.
  • Deciphering growth 2005
  • "The idea of producing a book on the prevention of chronic diseases through exercise and diet was intriguing for me when I was first approached with the idea. I had been teaching nutrition, exercise, and health science courses with a focus on cellular aspects of prevention for many years and had to develop all of my own materials because very few books were available. And of those that were, they had a decided clinical approach with very little discussion about the actual biochemistry or molecular mechanisms involved in prevention. When I broached the concept with several potential coauthors, the prevailing opinion was that books that covered biochemical and molecular aspects of disease etiology also were in very short supply. Thus this book was born: an attempt to collate the latest cellular- and molecularbased research on the etiology of chronic diseases with how these mechanisms of cause are modified by various aspects of diet and exercise. Essentially, we have tried to produce a text that translates molecular-based data on etiology and prevention into a clinical prescription for the prevention of chronic disease. The focus on diabetes, atherosclerosis, osteoporosis, cancer, and degenerative neurological disease is because they are the major causes of morbidity and mortality by chronic disease and also because there is sufficient molecular evidence for a strong dietary and activity (or rather, an insufficiency of both) component to their etiology. The inclusion of a separate chapter on "Inflammation" became necessary when it was clear that inflammatory signaling is a fundamental component of each of these diseases and that reducing inflammation is key to reducing risk for all of these diseases. At the time we started, obesity had not yet been declared a diseas"-- Provided by publisher.
  • "There has been a long standing controversy in the field of sports nutrition regarding the role of protein and protein metabolism in muscle development and athletic performance. The understanding of protein nutrition has changed dramatically over the last decade and this book aims to clarify and modernize the topic. This book presents the efficacy, safety, and recommendations of protein intake among strength athletes. Including case studies, the text covers historical perspectives of protein use; safety of high protein diets; specific protein types and timing of intake; weight control using protein; protein synthesis and breakdown; and nitrogenous compounds/supplements"--Provided by publisher.
  • Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathana (TM)s and Beaa (TM)s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
  • Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more. Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.The most acclaimed and accomplished series in neuroscienceThis volume looks at dopamine researchin the light of the newest scholarly discoveries and insights.
  • User-friendly and well organized, Easy EMG is designed to help residents learn the fundamental principles of electrodiagnostic testing (including nerve conduction studies and needle EMG). This one-of-a-kind resource offers expert guidance on performing and interpreting EMGs, as well as how to test the most common conditions encountered in daily practice. At-a-glance tables combine with clear illustrations and a pocket-sized format to make Easy EMG ideal for on-the-go reference!
  • 2013 ClinicalKey
    Approach to Nerve Conduction Studies and Electromyography -- Anatomy and Neurophysiology -- Basic Nerve Conduction Studies -- Late Responses -- Blink Reflex -- Repetitive Nerve Stimulation -- Anomalous Innervations -- Artifacts and Technical Factors -- Basic Statistics for Electrodiagnostic Studies -- Routine Upper Extremity, Facial, and Phrenic Nerve Conduction Techniques -- Routine Lower Extremity Nerve Conduction Techniques -- Basic Overview of Electromyography -- Anatomy for Needle Electromyography -- Basic Electromyography: Analysis of Spontaneous Activity -- Basic Electromyography: Analysis of Motor Unit Action Potentials -- Clinical-Electrophysiologic Correlations: Overview and Common Patterns -- Median Neuropathy at the Wrist -- Proximal Median Neuropathy -- Ulnar Neuropathy at the Elbow -- Radial Neuropathy -- Peroneal Neuropathy -- Femoral Neuropathy -- Tarsal Tunnel Syndrome -- Facial and Trigeminal Neuropathy -- Polyneuropathy -- Amyotrophic Lateral Sclerosis and its Variants -- Atypical Motor Neuron Disorders -- Radiculopathy -- Brachial Plexopathy -- Proximal Neuropathies of the Shoulder and Arm -- Lumbosacral Plexopathy -- Sciatic Neuropathy -- Neuromuscular Junction Disorders -- Myopathy -- Myotonic Muscle Disorders and Periodic Paralysis Syndromes -- Approach to Electrodiagnostic Studies in the Intensive Care Unit -- Approach to Pediatric Electromyography -- Basics of Electricity and Electronics for Electrodiagnostic Studies -- Electrical Safety and Iatrogenic Complications of Electrodiagnostic Studies.
  • The scope of the EMG examination -- Routine clinical electromyography -- Specialized electrodiagnostic studies -- Electrodiagnostic findings in neuromuscular disorders.
  • Field Potential Generation and Current Source Density Analysis / L. Stan Leung -- Current Source Density Analysis of Ongoing Neural Activity: Theory and Application / Yonghong Chen, Mukesh Dhamala, Anil Bollimunta, Charles E. Schroeder, Mingzhou Ding -- The Juxtacellular Recording-Labeling Technique / Didier Pinault -- Neural Recording Using Digital Telemetry / André A. Fenton, Kathryn J. Jeffery, James G. Donnett -- Large-Scale Neural Ensembles in Mice: Methods for Recording and Data Analysis / Hui Kuang, Joe Z. Tsien -- Behavioral Correlates of Neuronal Activity Recorded as Single-Units: Promises and Pitfalls as Illustrated by the Rodent Head Direction Cell Signal / Robert W. Stackman -- Event-Related Potentials of the Cerebral Cortex / Steven L. Bressler -- Multisite Spike-Field Coherence, Theta Rhythmicity, and Information Flow Within Papez's Circuit / Zimbul Albo, Gonzalo Viana Prisco, Robert P. Vertes -- Cognitively Relevant Recoding in Hippocampus: Beneficial Feedback of Ensemble Codes in a Closed Loop Paradigm / Robert E. Hampson, John D. Simeral, Theodore W. Berger, Dong Song, Rosa H. Chan, Vasilis Z. Marmarelis, Sam A. Deadwyler -- An Intact Septo-Hippocampal Preparation for Investigating the Mechanisms of Hippocampal Oscillation / Romain Goutagny, Jesse Jackson, Sylvain Williams -- Targeted Modulation of Neural Circuits: A New Treatment Strategy for Neuropsychiatric Disease / Helen S. Mayberg, Paul E. Holtzheimer.
  • Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • Introduction to the endocrine system -- Endocrine function of the gastrointestinal tract -- Energy metabolism -- Calcium and phosphate homeostasis -- Hypothalamus-pituitary complex -- The thyroid gland -- The adrenal gland -- Life cycle of the male and female reproductive system -- The male reproductive system -- The female reproductive system -- Fertilization, pregnancy, and lactation.
  • Introduction, Energy Balance in Animals -- Energy Balance -- Limits in Energy Expenditure -- Energy Expenditure, Physical Activity, Body Weight and Body Composition -- Extremes in Energy Intake -- Body Weight -- Growth, Growth Efficiency and Ageing -- Modern Man in Line with Wild Mammals.
  • Enzinger and Weiss's Soft Tissue Tumors is a medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
  • 1. Chloride ATPase Pumps in Epithelia -- 2. Divalent Anion Transport in Crustacean and Molluscan Gastrointestinal Epithelia -- 3. Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes -- 4. Epithelial Calcium Transport in Crustaceans: Adaptation to Intrinsic and Extrinsic Stressors -- 5. The Cellular Basis of Extreme Alkali Secretion in Insects: A Tale of Two Tissues -- 6. H+, Na+, K+, and Amino Acid Transport in Caterpillar and Larval Mosquito Alimentary Canal -- 7. CFTR-Dependent Anion Transport in Airway Epithelia -- 8. Sulfate and Phosphate Transporters in Mammalian Renal and Gastrointestinal Systems -- 9. Role of H+-K+ ATPase, Na+-K+-2Cl⁻ and Na+-Cl⁻-HCO₃ ⁻ Transporters in Vertebrate Small Intestine -- 10. The H+- and H+, K+-ATPases of the Collecting Duct -- 11. Acid/Base Regulation in Renal Epithelia by H,K-ATPases -- 12. Sodium Transport Mechanisms in the Mammalian Nephron -- 13. Renal Acid-Base Regulation Via Ammonia Transport in Mammals -- 14. Hexose Transport Across Mammalian Epithelia -- 15. Amino Acid Transport by Epithelial Membranes -- 16. Molecular Ontology of Amino Acid Transport.
  • Chapter 1. Overview of the stress response / Marius Locke -- Chapter 2. Transcriptional regulation of the mammalian heat shock genes / Jenny S.L. Ho and J. Timothy Westwood -- Chapter 3. Heat shock proteins and their induction with exercise / Earl G. Noble -- Chapter 4. HSPs and protein synthesis in striated muscle / Donald B. Thomason and Vandana Menon -- Chapter 5. Stress proteins and myocardial protection / Joseph W. Starnes -- Chapter 6. Heat shock proteins and reactive oxygen species -- Karyn L. Hamilton and Scott K. Powers -- Chapter 7. Stress proteins and exercise-induced muscle damage / Anne McArdle and Malcolm J. Jackson -- Chapter 8. Stress proteins and the mitochondrion / David A. Hood, Arne A. Rungi, Marco Colavecchia, Joseph W. Gordon, and Jeremy J. Schneider -- Chapter 9. Gender-specific regulation of HSP70: mechanisms and consequences / Zain Paroo and Earl G. Noble -- Chapter 10. The role of heat shock proteins in modulating the immune response / Pope L. Moseley -- Chapter 11. Stress proteins and applied exercise physiology / Jürgen M. Steinacker and Yuefei Liu.
  • Ancient and early influences / Jack W. Berryman -- The neuromuscular system / Alan J. McComas -- The cardiovascular system / Loring B. Rowell -- The respiratory system / Jerome A. Dempsey and Brian J. Whipp -- The autonomic nervous system / Charles M. Tipton -- The oxygen transport system and maximal oxygen uptake / Jere H. Mitchell and Bengt Saltin -- The metabolic systems: aerobic metabolism and substrate utilization in exercising skeletal muscle / R. James Barnard and John O. Holloszy -- The metabolic systems: anaerobic metabolism (glycolytic and phosphagen) / George A. Brooks and L. Bruce Gladden -- The endocrine system: metabolic effects of the pancreatic, adrenal, thyroidal, and growth hormones / Michael C. Riddell ... [et al.] -- The temperature regulatory system / Elsworth R. Buskirk -- The renal system / Jacques R. Poortmans and Edward J. Zambraski -- The gastrointestinal system / Carl V. Gisolfi
  • Anatomy of joints, general considerations and principles of joint examination / George V. Lawry, Dennis Bewyer -- The shoulder / Murray J. Beuerlein , Michael D. McKee, Adel Fam -- The elbow / George V. Lawry, Terry Axelrod, Elizabeth Grigoriadis -- The wrist and hand / Arthur A.M. Bookman, Herbert P. von Schroeder, Adel Fam -- The hip / Hans J. Kreder -- The knee / Hans J. Kreder and Gillian Hawker -- The ankle and foot / Gregory W. Choy, David Stephen, Adel Fam -- The spine / George Lawry ... [et al.] -- The temporomandibular joint / Michael B. Goldberg ... [et al.] -- Principles of joint and periarticular aspirations and injections / Gillian Hawker, Elizabeth Grigoriadis, Adel G. Fam.
  • Fibromyalgia definition and epidemiology -- Pathophysiology of fibromyalgia -- Assessment and diagnosis -- Headache -- Chronic fatigue syndrome -- Irritable bowel syndrome -- Sleep disturbance -- Depression and anxiety -- Obesity and metabolic syndrome -- Published recommendations -- Medication treatments -- Non-medication treatments -- Nutritional supplements -- Clinical handouts -- Fibromyalgia and pregnancy -- Fibromyalgia in seniors -- Gender and ethnic issues.
  • Preface -- The Epidemiology and Prevalence of Fibromyalgia -- Fibromyalgia Diagnosis -- Etiology -- Prognosis -- Lifestyle Modification and Fibromyalgia -- Psychological Treatment for Fibromyalgia -- Medications -- Adjuvant Treatments for Fibromyalgia -- Utilizing Clinical Treatments with a Limited Evidence Base -- Treatment of Special Groups: Children, Pregnant, Elderly and Mentally-disabled -- Emerging Developments -- Nutrition.
  • Fish bioacoustics 2008
    Introduction to fish bioacoustics / Richard R. Fay, Arthur N. Popper, and Jacqueline F. Webb -- Hearing and acoustic behavior: basic and applied considerations / Arthur N. Popper and Carl R. Schilt -- Structures and functions of the auditory nervous system of fishes / Richard R. Fay and Peggy L. Edds-Walton -- Evolution of peripheral mechanisms for the enhancement of sound reception / Christopher B. Braun and Terry Grande -- Bioacoustics and the lateral line system of fishes / Jacqueline F. Webb, John C. Montgomery, and Joachim Mogdans -- Orientation to auditory and lateral line stimuli / Olav Sand and Horst Bleckmann -- Multipole mechanisms for directional hearing in fish / Peter H. Rogers and David G. Zeddies -- Vocal-acoustic communication: from neurons to behavior / Andrew H. Bass and Friedrich Ladich -- Active and passive acoustics to locate and study fish / David A. Mann, Anthony D. Hawkins, and J. Michael Jech.
  • Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
  • Functional independence : a lifelong goal -- Theories affecting development -- Motor development -- Motor control and motor learning -- Evaluation of function, activity, and participation -- Skeletal system changes -- Muscle system changes -- Cardiovascular and pulmonary systems changes -- Nervous system changes -- Sensory system changes -- Vital functions -- Posture and balance -- Locomotion -- Prehension -- Health and fitness.
  • 1. Introduction -- 2. Force Vector -- 3. Moment and Torque Vectors -- 4. Statics: Systems in Equilibrium -- 5. Applications of Statics to Biomechanics -- 6. Introduction to Dynamics -- 7. Linear Kinematics -- 8. Linear Kinetics -- 9. Angular Kinematics -- 10. Angular Kinetics -- 11. Impulse and Momentum -- 12. Introduction to Deformable Body Mechanics -- 13. Stress and Strain -- 14. Multiaxial Deformations and Stress Analyses -- 15. Mechanical Properties of Biological Tissues -- Appendex A. Plane Geometry -- Appendix B. Vector Algebra -- Appendix C. Calculus.
  • Transport processes represents important life sustaining elements in all humans. These include mass transfer processes, including gas exchange in the lungs, transport across capillaries and alveoli, transport across the kidneys, and transport across cell membranes. These mass transfer processes affect how oxygen and carbon dioxide are exchanged in your bloodstream, how metabolic waste products are removed from your blood, how nutrients are transported to tissues, and how all cells function throughout the body. A discussion of kidney dialysis and gas exchange mechanisms is included. Another element in biomedical transport processes is that of momentum transport and fluid flow. This describes how blood is propelled from the heart and throughout the cardiovascular system, how blood elements affect the body, including gas exchange, infection control, clotting of blood, and blood flow resistance, which affects cardiac work. A discussion of the measurement of the blood resistance to flow (viscosity), blood flow, and pressure is also included. A third element in transport processes in the human body is that of heat transfer, including heat transfer inside the body towards the periphery as well as heat transfer from the body to the environment. A discussion of temperature measurements and body protection in extreme heat conditions is also included.
  • The cell -- The cell membrane -- Genes and proteins -- Control systems and homeostasis -- Functional anatomy of the nervous system -- Resting membrane potential -- Membrane excitation and action potential -- Electrophysiology of ion channels -- Conduction of the action potential -- Sensory mechanisms -- Transmission of neuromuscular junctions and synapes -- The autonomic nervous system -- Functional anatomy of muscle -- Mechanism of muscle contraction -- Characteristics of muscle contraction -- Muscle elasticity -- Muscle mechanics -- Smooth muscle -- Cardiac muscle -- Body fluids and blood -- Red blood cells -- Hemoglobin -- Hemopoiesis -- Hermatinic factors -- Blood grouping and transfusion -- Blood platelets and hemostasis -- Hemostatic balance -- Granulocytes -- Agranulocytes and lymphoid organs -- Immunity, tolerance, and hypersensitivity -- Immune mechanisms -- Cardiac excitation and the electrocardiogram -- Cardiac cycle -- Cardiac output -- Circulatory pathway and hemodynamics -- Capillary exchange and lymphatic circulation -- Chemical and neural control of the cardiovascular system -- Blood pressure regulation -- Coronary circulation -- Cerebral circulation -- Pulmonary and pleural circulation -- Cutaneous, muscle, and splanchnic circulation -- Regulation of body temperature -- Functional anatomy of the respiratory system -- Mechanics of pulmonary ventilation -- Measurements of pulmonary ventilation -- Alveolar ventilation, perfusion, and gas exchange -- Transport of gases -- Neural control of respiratory rhythm -- Chemical control of pulmonary ventilation -- Respiration in unusual environments -- Pulmonary function tests and respiratory disorders -- Functional anatomy of the kidney -- Glomerular filtration and tubular reabsorption -- Renal handling of sodium -- Renal mechanisms determining urine osmolarity -- Body fluid and electrolyte balance -- Renal contribution to acid-base balance -- Renal handling of miscellaneous substances -- Hormones acting on the kidney -- Quantification of renal functions -- Whole body acid-base balance -- Renal syndromes -- Urinary bladder and micturition -- Nutritional needs of the body -- Functions of the mouth and esophagus -- Functions of the stomach -- Functions of the duodenum -- Functions of the small intestine -- Function of the colon -- Gastrointestinal hormones -- Gastrointestinal disorders -- Metabolic pathways -- Mechanism of hormonal action -- Hypothaoamic and pituitary hormones -- Thyroid hormones -- Hormones regulating calcium balance -- Hormones of the adrenal cortex -- Hormones of the adrenal medulla -- Pancreatic hormones and the regulation of blood glucose -- Testicular and ovarian hormones -- Puberty and gametogenesis -- Menstrual cycle -- Sperm transport and fertilization -- Sexual differentiation of the fetus -- Pregnancy -- Parturition and lactation -- Appendix A: Principles of physics in physiology -- Appendix B: Principles of chemistry in physiology -- Appendix C: Abbreviations used in text.
  • Section I. Overview of sleep medicine -- Section II. Anatomy and physiology -- Section III. Sleep disorders and disorders that affect sleep -- Section IV. Patient care and assessment -- Section V. Polysomnography -- Section VI. Interventions and therapeutics -- Section VII. Ancillary procedures -- Section VIII. Pediatrics -- Section IX. Sleep center management -- Section X. Appendix.
  • This volume provides a practical hands on guide to gastrointestinal physiology. The book emphasizes an appreciation of basic physiological concepts and their application to novel clinical situations. It exposes the physician-in-training to fundamental principles that are useful in treating patients and lays the groundwork for more advanced study in the future. The authors present relevant cases which incorporate newer adult learning strategies in medical education. These cases provide a forum in which the student can apply acquired knowledge, skills and attitudes. Connections are made to reader's life, whether in the classroom, on the wards or out and about town. Designed for medical students who are studying gastrointestinal physiology for the first time, Gastrointestinal Physiology: A Clinical Approach provides a superb review for upper level medical students and house officers. Nursing and allied health professions students will also find this text to be a useful guide. GI fellows and attending physicians in need of a concise review of fundamental GI physiology principles will also benefit from reading this book.
  • Gastrointestinal Physiology explains the operation and performance of one of the body's most crucial systems. Using clear, compelling language, the book's presentation makes it easy to absorb the content and integrate it as you learn the physiology of other bodily systems. Written to help you understand essential concepts rather than merely memorize facts, this unique text examines many medically relevant facets of this important body system, including anatomy, pathophysiology, and therapeutics, in concert with physiological information.
  • Basic physiology of the growth hormone/insulin-like growth factor (IGF)-axis / Laura M. Frago and Julie A. Chowen -- Experimental models for understanding the role of insulin-like growth factor-I and its receptor during development / Jose Luis Trejo, Eva Carro, and Deborah J. Burke -- Insulin-like growth factor binding proteins in development / Josef V. Silha and Liam J. Murphy -- Growth hormone, insulin-like growth factors, and the female reproductive system / Carolyn A. Bondy and Jian Zhou -- Skeletal muscle / Ana M. Fernandez and Derek LeRoith -- Cardiovascular and respiratory systems / Åsa Tivesten and Jörgen Isgaard -- Hematopoiesis / Wilson Savino, Salete Smaniotto, and Mireille Dardenne -- Brain development / Gregory J. Popken ... [et al.] -- Regulation of vertebrate sensory organ development : a scenario for growth hormone and insulin-like growth factors action / Amelia Diaz-Casares ... [et al.] -- Role of insulin-like growth factors in neuronal plasticity and neuroprotection / Ignacio Torres Alemán -- Aging and life span / Holly M. Brown-Borg -- Interactions of insulin-like growth factor-I and estrogen in the brain / Pablo Mendez, Gloria Patricia Cardona-Gomez, and Luis Miguel García-Segura -- Cancer / Adda Grimberg -- Genetic basis of proportional short stature / Ángel Campos-Barros, Karen E. Heath, Jesús Argente -- Future perspectives : from stem cells and IGF biology to the clinic / Yvan Arsenijevic.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. 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