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PharmacyAccess restricted to Stanford unless otherwise noted

  • Advanced pharmaceutics 2004, CRCnetBASE
  • Adverse drug reactions 2010, Springer
    Pt. 1. Target organ toxicity. -- Drug-induced liver injury / Michael Holt, Cynthia Ju.-- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler.-- Adverse drug reactions affecting blood cells / Richard H. Aster.-- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi.-- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb.-- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells, Crystal J.J. Lee, Gordon P. McCallum, Julia Perstin, Patricia A. Harper.-- Pt. II. Mediators/Biochemical pathways.-- Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park.-- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh.-- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park.-- Signal transduction pathways involved in drug-induced liver injury / Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi, Neil Kaplowitz.-- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre, Abdellah Mansouri, Alain Berson, Bernard Fromenty.-- Pt. III. Examples/Models.-- Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James.-- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson.-- Troglitazone / Tsuyoshi Yokoi.-- Neviropine hypersensitivity / M. Popovic, J.M. Shenton, J. Chen, A. Baban, T. Tharmanathan, B. Mannargudi, D. Abdulla, J.P. Uetrecht.-- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke.-- Pt. IV. Risk factors/Screening drug candidates.-- Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed.-- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht.-- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar, Kaushik Mitra, Kelem Kassahun, Thomas A. Baillie.
  • This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.
  • Omics & microarrays revisited -- The commercial microarrays -- Supports & surface chemistries -- The arraying processes -- Gene expression microarray-based applications -- Protein microarray applications -- Multiplex assays.
  • ch. 1. Nitrilases and nitrile hydratases / Robert DiCosimo -- ch. 2. Biocatalytic deracemization : dynamic resolution, stereoinversion, enantioconvergent processes, and cyclic deracemization / Yolanda Simeo, Wolfgang Kroutil, and Kurt Faber -- ch. 3. A decade of biocatalysis at Glaxo Wellcome / Mahmoud Mahmoudian -- ch. 4. Biocatalysis for synthesis for chiral pharamaceutical intermediates / Ramesh N. Patel -- ch. 5. Directed evolution of lipases and esterases for organic synthesis / Aurelio Hidalgo and Uwe T. Bornscheuer -- ch. 6. Flavin-containing oxidative biocatalysts / Marco W. Fraaije and Willem J.H. van Berkel -- ch. 7. Preparation of chiral pharmaceuticals through enzymatic acylation of alcohols and amines / Vicente Gotor-Fernandez, Francisca Rebolledo, and Vicente Gotor -- ch. 8. Dynamic kinetic resolution and asymmetric transformations by enzyme-metal combinations / Mahn-Joo Kim, Yangsoo Ahn, and Jaiwook Park -- ch. 9. Biotransformation of natural or synthetic compounds for the generation of molecular diversity / Robert Azerad -- ch. 10. Applications of aromatic hydrocarbon dioxygenases / Rebecca E. Parales and Sol M. Resnick -- ch. 11. A genomic approach to investigating baker's yeast reductions / Jon D. Stewart -- ch. 12. Immobilization of enzymes as cross-linked enzyme aggregates : a simple method for improving performance / Roger A. Sheldon -- ch. 13. Biotechnological applications of aldolases / Wolf-Dieter Fessner and Stefan Jennewein -- ch. 14. Enzymatic synthesis of modified nucleosides / Luis A. Condezo ... [et al.] -- ch. 15. Biocatalytic reduction of carbozylic acids : mechanism and applications / Padmesh Venkitasubramanian, Lacy Daniels, and John P.N. Rosazza -- ch. 16. Dehalogenases in biodegradation and biocatalysis / Dick B. Janssen -- ch. 17. Enzymatic synthesis of sugar esters and oligosaccharides from renewable resources / A. Ballestros ... [et al.] -- ch. 18. Efficient methods and instrumentation for engineering custom enzymes / Steven J. Robles, William J. Coleman, and Mary M. Yang -- ch. 19. Deaminating enzymes of the purine cycle as biocatalysts for chemoezymatic synthesis and transformation of antiviral agents structurally related to purine nucleosides / Enzo Santaniello, Pierangela Ciuffreda, and Laura Alessandrini -- ch. 20. Mircobial and enzymatic processes for the production of chiral compounds / Kohsuke Honda ... [et al.] -- ch. 21. Discovery of arylmalonate decarbozylase and conversion of the function by rational design / Kenji Miyamoto and Hiromichi Ohta -- ch. 22. Chemoenzymatic preparation of enantiopure building blocks of synthetic utility / Kenji Mori -- ch. 23. Stereoselective modifications of polyhydorxylated steroids / Elena Fossati and Sergio Riva -- ch. 24. Recent developments in enzymatic acyloin condensations / Owen Ward and Ajay Singh -- ch. 25. Synthesis of chiral alcohols with carbonyl reductase library and robust NAD(P)H regenerating system / Hiroaki Yamamoto and Akinobu Matsuyama -- ch. 26. Comparative analysis of chemical and biocatalyic syntheses of drug intermediates / Michael J. Homann ... [et al.] -- ch. 27. Industrial processes using lyases fo C-C, C-N, and C-O bond formation / Martina Pohl an Andreas Lieses -- ch. 28. State of the art and applications in stereoselective synthesis of chiral cyanohydrins / Franz Effenberger, Siegfried Forster, and Christoph Kobler -- ch. 29. Chiral switches : problems, strategies, opportunities, and experiences / Rene Csuk -- ch. 30. Enzyme evolution for chemical process applications / Gjalt W. Huisman and James J. Lalonde -- ch. 31. Biocatalytic routes to nonracemic chiral amines / Nicholas J. Turner and Reuban Carr -- ch. 32. Enantioselective biocatalytic reduction of ketones for the synthesis of optically active alcohols / Stefan Buchholz and Harald Groger -- ch. 33. Enyzmes catalysis in nonaqueous media : past, present and future / Susanne Dreyer ... [et al.] -- ch. 34. Biocatalyic concepts for the synthesis of optically active amines / Stefan Buchholz and Harald Groger.
  • "... provides an established, recognized, authoritative and comprehensive source on medicinal chemistry and drug discovery and development. This flagship reference for medicinal chemists and pharmaceutical professions has been thoroughly updated and expanded across 8 volumes to incorporate the entire process of drug development (preclinical testing, clinical trials, etc.) alongside the traditional strengths in medicinal chemistry and drug discovery"--Provided by publisher.
  • An effective CMC regulatory compliance strategy for biologics and biopharmaceuticals can seem like a mystery. Through means of this 2nd edition, this no longer needs to occur. A great deal of thanks goes to two regulatory authorities - the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA), who provide through their respective websites, an abundance of guidance, especially in the last several years. So much has changed since the 1st edition of this book was published in 2004. There are now additional manufacturing processes for producing commercial biopharmaceuticals - transgenic plant cell cultures and transgenic animals. In addition to commercial recombinant proteins and monoclonal antibodies, there are now commercial cell-based medicines (cellular therapy) and DNA-based medicines (gene therapy). Biosimilars are now on the marketplace in Europe, and under review for commercial approval in the USA. Vaccine manufacturing has resurged due to the concerns of potentially pandemic mutated animal influenzas (e.g., swine flu, bird flu). Strategic international regulatory guidances have been adopted that are driving the entire pharmaceutical industry, including biopharmaceuticals, to a higher standard of performance, including Quality by Design (QbD), Quality Risk Management (QRM) and Pharmaceutical Quality Systems (PQS). The vast majority of the over 600 regulatory references listed in this book were either issued or updated since the release of the 1st edition. All of these changes are the reason this updated edition includes not only biopharmaceuticals but also other biologics (e.g., live virus vaccines, human plasma-derived proteins, cell-based medicines, natural-sourced proteins) that have CMC regulatory compliance concerns and challenges in common with the genetically-engineered biologics (i.e., the biopharmaceuticals).
  • Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / Joseph Rogers ... [et al.] -- Treatment development strategies for Alzheimer's disease / Ernst Wulfert -- Lipoprotein-associated phospholipase A as a new prognostic factor for coronary artery disease / Alexandros D. Tselepis -- New molecular targets for the prevention and treatment of gastrointestinal ulcers and inflammation / Sandor Szabo ... [et al.] -- Stress activates corticotropin releasing : factor signaling pathways : implication in functional bowel disorders / Yvette Tache -- Design, synthesis, and pharmacological evaluation of high-affinity and selectivity sigma-1 and sigma-2 receptor ligands / Jacques H. Poupaert -- Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy -- From the molecular pharmacology to the medicinal chemistry of cannabinoids / Didier M. Lambert -- An appraisal of fomocaines : current situation and outlook / Herbert Oelschlager and Andreas Seeling -- Ligands for the GABA recognition site at the GABAA receptor : structure-activity studies / Bente Frlund ... [et al.] -- Strategies for development of new lead structures for inhibition of acetylcholinesterase / Petra Kapkova ... [et al.] -- Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2) : a new target for the treatment of congestive heart failure and myocardial fibrosis--a review / R.W. Hartmann ... [et al.] --Thiocarboxanilides : a new class of nonnucleoside reverse transcriptase inhibitors (NNRTIs) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini -- Histamine H-receptor agonists and antagonists : chemical, pharmacological, and clinical aspects / Holger Stark and Walter Schunack -- Anti-inflammatory actions of flavonoids and structural requirements for new design / Theoharis C. Theoharides -- Molecular mechanisms of HO-induced DNA damage : the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris -- LNA (locked nucleic acid) and functionalized LNA : towards efficient gene targeting / Jesper Wengel -- The effect of diet on drug metabolism / K.J. Netter -- Cytochromes P450 in the metabolism and bioactivation of chemicals / Costas Ioannides -- In vitro methods to measure drug metabolism and drug interactions in drug discovery and development / O. Pelkonen ... [et al.] -- How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter -- Physicochemical profiling in early drug discovery : new challenges at the age of high-throughput screen and combinatorial chemistry / Bernard Faller -- Drug membrane interaction and its importance for drug efficacy / J.K. Seydel ... [et al.] -- The fight against AIDS : new avenues for inhibiting reverse transcriptase (RT), and old target / Maurizio Botta ... [et al.].
  • Part 1. Synthesis and characterization of chitin and chitosan derivatives -- part 2. Biological activities of chitin and chitosan derivatives -- part 3. Biomedical applications of chitin and chitosan derivatives.
  • Introduction : the practice of clinical pharmacy -- Communication skills for the pharmacist -- Taking medication histories -- Physical assessment skills -- Review of laboratory and diagnostic tests -- The patient case presentation -- Therapeutics planning -- Monitoring drug therapies -- Researching and providing drug information -- Ethics in pharmacy and health care.
  • Combination products 2008, CRCnetBASE
    Overview of combination products -- Ensuring successful combination product development -- Overview of FDA and other regulatory agency expectations -- Resource requirements -- Manufacturing of combination products -- Challenges and pitfalls to avoid with combination products -- Postlaunch compliance requirements -- Agency audits and challenges.
  • Introduction / Wayne R. Gombotz and Steven J. Shire -- Design of therapeutic MABS. CDR repair: a novel approach to antibody humanization / Mark S. Dennis -- Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies / Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens -- Expression and production of MABS. GPEx® a flexible method for the rapid generation of stable, high expressing, antibody producing mammalian cells lines / Gregory T. Bleck -- Advancing our cell culture platform: incorporating lessons learned and new technologies / Carole Heath -- Recovery and purification. Addressing changes associated with technology transfer: a case study / Michele M. Myers ... [et al.] -- Concepts for disposables in biopharmaceutical manufacture / Joachim K. Walter and Uwe Gottschalk -- Formulation and delivery. Formulation and delivery issues for monoclonal antibody therapeutics / Ann L. Daugherty and Randall J. Mrsny -- Challenges in the development of high protein concentration formulations / Steven J. Shire, Zahra Shahrock, and Jun Liu -- Protein immobilization by crystallization and precipitation: an alternative to lyophilization / Karoline Bechtold-Peters -- Analytics and specification setting for MABS. Characterizing high affinity antigen/antibody complexes by kinetic and equilibrium based methods / Andrew W. Drake, David G. Myszka, and Scott L. Klakamp -- Analytical characterization of monoclonal antibodies: linking structure to function / Reed J. Harris ... [et al.] -- Analysis of irreversible aggregation, reversible self-association and fragmentation of monoclonal antibodies by analytical ultracentrifugation / James D. Andya, Jun Liu, and Steven J. Shires -- Biophysical signatures of monoconal antibodies / N. Harn ... [et al.] -- Pharmacokinetics and immunogenicity. Impact of Fc glycosylation on monoclonal antibody effector functions and degradation by proteases / T. Shantha Raju -- Immunogenicity assessment of antibody therapeutics / P. stas, Y. Gansemans, and I. Lasters -- Armed antibodies and new classes of antibodies. Production of monoclonal antibodies in E. coli / Dorothea E. Reilly and Daniel G. Yansura -- Recent advances in the use of antibody drug conjugates for cancer theapy / Peter D. Senter -- Antibody radiolabeling / Corinne Bensimon and Russell Redshaw.
  • Depression 2010, Karger
    Antidepressant compounds : a critical review / S.W. Tang, D.M. Helmeste, B. Leonard -- The hypothalamic-pituitary-adrenal axis in depression / M. Julio-Pieper, T.G. Dinan -- Dysfunctional circadian rhythms and mood disorders : opportunities for novel therapeutic approaches / T.R. Norman -- The concept of depression as a dysfunction of the immune system / B.E. Leonard -- The role of polyunsaturated fatty acids in the pathology and treatment of depression / C. Song -- Overcoming antidepressant treatment resistance : focus on glutamate / J.W. Murrough, S.J. Mathew -- Neuroimaging and the pathophysiology and treatment of depression : recent advances and future needs / D.M. Cannon -- Animal models of depression : where are we going? / D.A. Slattery, J.F. Cryan -- Genetic models of depression and antidepressant response / I. Lucki -- The role of 5-HT2C receptors in the antidepressant response : a critical review / C.B.P. Martin ... [et al.] -- Chromatin-based treatments for affective disorders : insight or utopia / H.E. Covington III, O. Berton -- Neurotrophic factors and antidepressant action : recent advances / O.F. O'Leary, E. Castron -- Neurogenic basis of antidepressant action : recent advances / A. Tanti, C. Belzung -- The nature and treatment of therapy-resistant depression / S.H. Kennedy, S.J. Rizvi, P. Giacobbe -- Optimizing antidepressant management of depression : current status and future perspectives / T.L. Schwartz, S.M. Stahl.
  • This dictionary details various terms typically used in pharmaceutical medicine. It also explains commonly used abbreviations.
  • Introduction. Drug discovery in the 21st century --ch. 1.Natural products /Charles B. Spainhour --ch. 2.Cancer cell proteomics using molecular aptamers /Weihong Tan ... [et al.] --ch. 3.Molecular similarity methods and QSAR models as tools for virtual screening /Jürgen Bajorath --ch. 4.Systems biology : applications in drug discovery /Sean Ekins ...[et al.] --ch. 5.High throughput flow cytometry /Larry A. Sklar ... [et al.] --ch. 6.Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity /Richard D. Beger, Dan A. Buzatu, and Jon G. Wilkes --ch. 7.Using Microsoft Excel as a laboratory data management tool /A. Erik Rubin, Mark F. Russo, and William Neil --ch. 8.Age of regulation /Sandy Weinberg and Gerald J. Whartenby --ch. 9.Simultaneous screening of multiple cell lines using the CellCard system /Oren E. Beske --ch. 10.Protein X-ray crystallography in drug discovery /Peter Nollert ... [et al.] --ch. 11.Biological and chemistry assays available during drug discovery and developability assessment /Duane B. Lakings --ch. 12.Strategies and methods in monitoring and targeting protein-protein interactions /Arianna Loregian and Giorgio Palù --ch. 13.High-throughput screening : evolution of technology and methods --Martyn N. Banks ... [et al.] --ch. 14.Metal-enhanced fluorescence : application to high-throughput screening and drug discovery /Kadir Aslan ... [et al.] --ch. 15.Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays /Brian J. Eastwood ... [et al.] --ch. 16.Coupled luminescent methods in drug discovery : 3-minute assays for cytotoxicity and phosphatase activity /Michael J. Corey and Robert J. Kinders --ch. 17.Design and pharmaceutical applications of prodrugs /Tomi Järvinen ... [et al.] --ch. 18.GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders /Ulf Madsen ... [et al.] --ch. 19.Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : novel ischemia-selective antiarrhythmic agents /George E. Billman --ch. 20.Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis /Peter C. Minneci ... [et al.] --ch. 21.Combinatorial chemistry in the drug discovery process /Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller --ch. 22.Herbal medicines and animal models of gastrointestinal diseases /C.H. Cho and J.K.S. Ko --ch. 23.Endocrine and metabolic agents /Brian L. Furman --ch. 24.Respiratory viruses /Paul D. Olivo --ch. 25.Strategies in the design of antiviral drugs /Erik De Clercq and Piet Herdewijn --ch. 26.Protein kinase inhibitors in drug discovery /Keykavous Parang and Gongqin Sun --ch. 27.RNA-based therapies /Steve Pascolo --ch. 28.Novel imaging agents for molecular MR imaging of cancer /Dmitri Artemov and Zaver M. Bhujwalla --ch. 29.Targets and approaches for cancer drug discovery /Susan L. Mooberry.
  • Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Interactions Between Herbs and Antiinfective Medications -- Drug-Cytokine Interactions -- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions with Antiretrovirals for HIV Infection -- Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelmintic Agents -- Drug Interaction Considerations Throughout Drug Development -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.
  • 1. Pharmacokinetics -- 2. Drug Metabolizing Enzymes -- 3. Oral Absorption -- 4. Transporters -- 5. Metabolism-Based Drug Interactions -- 6. Biotransformation and Bioactivation -- 7. Prediction of Human Pharmacokinetics -- 8. Advances in Bioanalysis as It Relates to ADME -- 9. ADME Properties and Their Dependence on Physicochemical Properties -- 10. In Silico ADME Tools -- 11. Approved Drugs -- 12. Chemical Nomenclature.
  • Electronic health record 2012, CRCnetBASE
    "This book introduces readers to structured systems analysis and the medications domains. It starts off with top-down decomposition of workflows and data. It applies structured systems analysis methodology and tools to electronic prescription, computerized physician order entry, drug dispensation, medication administration, and clinical decision support. Providing a comprehensive view of the EHR/EMR, the text covers user interface considerations, reporting requirements, and standards and vocabularies for meaningful use. Assuming no previous clinical and/or informatics knowledge, the author uses accessible language and includes over 250 figures and 100 review questions with answers"--Provided by publisher.
  • Introduction to the guidelines. Purpose, target and scope -- Background -- A dual obligation, a quadruple imperative -- Indispensability of controlled medicines in contemporary medical practices -- Safety of controlled medicines -- Current availability -- Impediments to availability, accessibility and affordability -- Why and how to work with this document? -- Guidelines for ensuring balance in national policies on controlled substances. Content of drug control legislation and policy -- Authorities and their role in the system -- Policy planning for availability and accessibility -- Healthcare professionals -- Estimates and statistics -- Procurement -- Other -- Country assessment checklist.
  • Essentials of pharmacy law 2003, CRCnetBASE
  • Facility validation 2004, CRCnetBASE
  • FDA regulatory affairs 2004, CRCnetBASE
  • FDA-speak. 2nd ed. 2002, CRCnetBASE
  • 1. Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs / Stephanie Bosselmann and Robert O. Williams III -- 2. Optimizing the Formulation of Poorly Water-Soluble Drugs / Kevin P. O'Donnell and Robert O. Williams III -- 3. Solid-State Techniques for Improving Solubility / Justin R. Hughey and Robert O. Williams III -- 4. Mechanical Particle-Size Reduction Techniques / Javier O. Morales, Alan B. Watts, and Jason T. McConville -- 5. Solubilized Formulations / Feng Zhang and James C. DiNunzio -- 6. Injectable Formulations of Poorly Water-Soluble Drugs / Michael P. Boquet and Dawn R. Wagner -- 7. Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs / Ping Gao -- 8. Structured Development Approach for Amorphous Systems / Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Oskar Kalb, Susanne Page, and Nicole Wyttenbach -- 9. Melt Extrusion / James C. DiNunzio, Feng Zhang, Charlie Martin, and James W. McGinity -- 10. Spray-Drying Technology / Dave A. Miller and Marco Gil -- 11. Pharmaceutical Cryogenic Technologies / Wei Yang, Donald E. Owens III, and Robert O. Williams III -- 12. Precipitation Technologies for Nanoparticle Production / Jasmine M. Rowe and Keith P. Johnston -- 13. Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs / Justin R. Hughey and James W. McGinity -- 14. Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs / Zedong Dong and Hasmukh Patel.
  • High-throughput gene cloning using the Gateway technology / Scott N. Peterson ... [et al.] -- Protein expression for microarrays / Harry H. Yim, Thomas G. Chappell, and Steven H. Harwood -- Emerging trend: cell-free protein expression / Federico Katzen and Wieslaw Kudlicki -- The critical role of surface chemistry in protein microarrays / Athena Guo and X.-Y. Zhu -- Fabrication of sol-gel-derived protein microarrays for diagnostics and screening / Nicholas Rupcich and John D. Brennan -- Printing and QC of functional protein microarrays / Dee Shen, Fang X. Zhou, and Barry Schweitzer -- Protein engineering for surface attachment / Aparna Girish, Grace Y. J. Chen, and Shao Q. Yao -- Protein in situ arrays through cell-free protein synthesis / Mingyue He ... [et al.] -- Fluorescent detection methods for protein microarrays / Steven Roman and Scott Clarke -- Functional analysis of protein interactions using surface plasmon resonance-based microarrays / Alan McWhirter and Stefan Löfås -- Leaving the surface behind: at the intersection of protein microarrays and mass spectrometry / Darrell P. Chandler ... [et al.] -- High-resolution label-free detection applied to protein microarray research / Lance G. Laing and Brian Cunningham -- Studying protein-protein interactions with protein microarrays: rapid identification of 14-3-3 protein binding partners / Jun-ichi Satoh -- A combined force of chemical genetics and protein microarrays / Heng Zhu and Jing Huang -- Antibody profiling for protein drug development and clinical development / Steve H. Herrmann -- Humoral response profiling using protein microarrays / Arun Sreekumar ... [et al.] -- DNA interactions with arrayed proteins / Marina Snapyan and Vehary Sakanyan -- G protein-coupled receptor microarrays for drug discovery / John Salon ... [et al.] -- Kinase substrate identification using yeast protein microarrays / Geeta Devgan and Michael Snyder -- Protein microarray image analysis / Minzi Ruan -- The analysis of protein arrays / Brad Love -- Evaluating precision and recall in functional protein arrays / Keith Robison -- Visualization of protein microarray data / Kevin Clancy.
  • Fundamental Implications for Clinical Practice -- Translational Effectiveness in the Context of Translational Science -- Comparative Effectiveness Analysis and Evidence-Based Decisions -- Methodology I: The Best Available Evidence -- Methodology II: Sampling and Assessment of the Evidence -- Methodology III: Systematic Evaluation of the Statistical Analysis: Data Analysis in Research Synthesis -- Optimizing Clinical Practice-Based Patient-Centered Outcomes Research -- Getting and Understanding Data -- Obtaining Data -- Describing and Analyzing Data -- Translational Effectiveness Analysis -- Optimizing Clinical Outcomes by Individualizing Observations -- Evaluation in Patient-Centered Outcomes Research -- Translational Effectiveness in Practice-Based Patient-Centered Outcomes Research.
  • Established as a classic text on nuclear chemistry and pharmacy, 'Fundamentals of Nuclear Pharmacy' has been thoroughly revised and now includes new information covering innovations in imaging technology and clinical applications in the field.
  • A perspective on the future clinical impact of genetic diagnosis and gene-based drug therapies for patient health / Julian W. Tang -- Virally-encoded microRNA (miRNA): candidates for gene silencing / Ralph A. Tripp ... [et al.] -- Development of gene profile-responsive antisense agents / Sergei A. Kazakov and Brian H. Johnston -- Gene profiles in drug development: applications in target identification, biomarker discovery, and compound characterization / Eric A.G. Blomme and Dimitri Semizarov -- Gene profiles and cancer / Beverly A. Teicher -- RNA viruses and RNA-based drugs: a perfect match for RNA delivery and the identification of candidate therapeutic target inflammatory molecules / Brett A. Lidbury ... [et al.] -- Ethical considerations for a genetic future in diagnosis and drug development / Lexie Brans and Brett A. Lidbury.
  • "This book collects in-depth discussions from more than 30 noted specialists on topics such as quality control, experimental formulations, pharmaceutical ingredients, conventional and modified-release products, and bioequivalence. It considers key elements in the formulation of generic drug products including the availability of raw materials and chemical purity. It contains new chapters on experimental formulation development, and the relationship between the FDA and the United States Pharmacopeia"--Provided by publisher.
  • Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases. Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs. Authored by leading international experts from industry and academia.
  • Particulate systems: manufacture and characterization -- Sampling and measurement biases -- Particle size descriptors and statistics -- Behavior of particles -- Instrumental analysis -- Methods of particle size measurement and their importance for specific applications (instrument synergy) -- Particle size behavior and physical behavior of a powder -- Clinical effect of pharmaceutical particulate systems.
  • There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.
  • Handbook of drug screening 2001, CRCnetBASE
  • v. 2, 2004 CRCnetBASE
    v. 3, 2004 CRCnetBASE
    v. 4, 2004 CRCnetBASE
    v. 5, 2004 CRCnetBASE
    v. 6, 2004 CRCnetBASE
    v. 1. Compressed solid products -- v. 2. Uncompressed solid products -- v. 3. Liquid products -- v. 4. Semisolid products -- v. 5. Over-the-counter products -- v. 6. Sterile products.
  • Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenias definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinicianpatient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patients adherence and overall treatment.
  • High dilution effects 2004, Springer
  • High throughput sample preparation techniques and their application to bioanalytical protocols and purification of combinatorial libraries / Krishna Kallury -- High-throughput quantitative bioanalysis / Katty X. Wan -- Optimizing LCMS equipment to increase throughput in pharmaceutical analysis / Michael G. Frank and Douglas E. Mcintyre -- Throughput improvement of bioanalytical LC-MS/MS by sharing of detector between HPLC systems / Min Shuan Chang and Tawakol El-Shourbagy -- High throughput strategies for metabolite identification in drug discovery / Patrick J. Rudewicz, Qin Yue, and Young Shin -- Utilizing micro parallel liquid chromatography for high-throughput analyses in the pharmaceutical industry / Sergio A. Guazzotti -- Strategies and techniques for higher throughput ADME/PK assays / Walter Korfmacher -- High-throughput analysis in drug metabolism during early drug discovery / Yau Yi Lau --High-throughput analysis in the support of process chemistry and formulation research & development in the pharmaceutical industry / Zhong Li -- On-line SPE LC/MS/MS for high throughput bioanalytical analysis / Dong Wei and Liyu Yang -- Applications of high-throughput analysis in therapeutic drug monitoring / Quanyun A. Xu and Timothy L. Madden -- High-throughput quantitative pharmaceutical analysis in drug metabolism and pharmacokinetics (DMPK) using liquid crhomatrography-mass spectrometry / Xiaohui Xu -- Designing high throughput HPLC assays for small and biological molecules / Roger K. Gilpin and Wanlong Zhou -- The advances in capillary and nano-HPLC technology for drug discovery and development / Frank J. Yang and Richard Yu -- High-throughput analysis of complex protein mixtures by mass spectrometry / Kojo S.J. Elenitoba-Johnson.
  • Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee.
  • Hooked 2007
    The Good, the bad, and the ugly : a story of two medications -- An Ethical framework -- The Pharmaceutical industry and the free market -- Patents, generic drugs, and academic science -- Research and profits -- Suppression of research data -- The Quality of pharmaceutical research -- The Drug rep: historical background -- The Drug rep today -- The Influence of drug reps: what the data show -- Continuing medical education -- Professional organizations and journal advertising -- The Industry and the consumer -- The FDA: from patent medicines to AIDS drugs -- The FDA and the industry, 1990-2004 -- Solutions: the management and divestment strategies -- Solutions requiring enhanced professionalism in medicine -- Solutions requiring regulatory reform.
  • Immunology for pharmacy 2012, ScienceDirect
  • Over the last 30-40 years, information technology (IT) has revolutionized professional life for millions of people around the world. IT has reduced the need for bulk storage of paper records by organizations, has enabled automation of tasks that were previously repetitive and labor-intensive, and carry them out in a fast and accurate way, has enabled economies of scale, improved efficiencies and enabled new ways of working that were hitherto impossible. In parallel with the rise of IT during the last 40 years, the role of the pharmacist - and the society in which pharmacists work - has changed considerably. Pharmacists are no longer principally compounders of medicines, but they are still responsible for ensuring that the patient receives the correct medicine, ensuring that the patient understands why they should take their medicine, and helping the patient with taking the medicine and being concordant with therapy.Information Technology in Pharmacy: an Integrated Approach provides a concise and practical general introduction to pharmacy IT, discusses issues surrounding the adoption of technology and how technologies may be utlilized by the pharmacy profession to exercise new professional roles and achieve new professional aspirations. This book will be of prime interest to practicing pharmacists at all levels, pharmacy students and pharmacy educators, but also to health informaticians, hospital and health care system administrators.
  • V. 1. Acebutolol -- Dapsone -- v. 2. Dauromycin -- Indigotin Disulfonate -- v. 3. Indole-3-Acetic Acid -- Phendimetrazine -- v. 4. Phenelzine -- Zoxazolamine -- v. 5. Raman spectra data -- Mass spectra of pesticides -- Mass spectra of derivatized drugs -- Gas chromatography/infrared spectra of drugs -- v. 6. Standard KBr infrared spectra and standard NMR solvent spectra -- Supplemental infrared spectra -- Supplemental NMR spectra -- Ultraviolet absorption maxima -- Infrared index -- Mass spectra indices of drugs -- Mass spectra indices of pesticides -- Molecular formula index -- Gas chromatographic data -- Index to specific compounds.
  • Chapter 1. Introduction to enzymes, receptors and the action of small molecule drugs -- chapter 2. Protein structure and function -- chapter 3. The small molecule drug discovery process : from target selection to candidate selection -- chapter 4. Protein therapeutics (introduction to biopharmaceuticals) -- chapter 5. Similarities and differences in the discovery and use of biopharmaceuticals and small-molecule chemotherapeutics -- chapter 6. Therapies for type 2 diabetes : modulating the incretin pathway using small molecule peptidase inhibitors or peptide mimetics -- chapter 7. The structure and business of biopharmaceutical companies including the management of risks and resources -- chapter 8. Discovery and development of the anticancer agent gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase -- chapter 9. Targeting HER2 by monoclonal antibodies for cancer therapy -- chapter 10. Recombinant human erythropoietin and its analogues -- chapter 11. Lysosomal storage disorders : current treatments and future directions -- chapter 12. Hormone replacement therapy -- chapter 13. Design of the anti-HIV protease inhibitor darunavir -- chapter 14. The case of anti-TNF agents -- chapter 15. Discovery of the cholesterol absorption inhibitor, ezetimibe.
  • Part I. Reviews -- 1. An Historical overview of drug discovery / Ana Sofia Pina, Abid Hussain, and Ana Cecília Roque -- 2. Ligand macromolecule interactions : theoretical principles of molecular recognition / Tammy Nolan, Nidhi Singh, and Christopher R. McCurdy -- 3. X-Ray cystallography in drug discovery / Ana Luísa Carvalho, José Trincão, and Maria João Romão -- 4. Virtual screening of compound libraries / Nuno M.F.S.A. Cerqueira, Sérgio F. Sousa, Pedro A. Fernandes, and Maria João Ramos -- Part II: Protocols -- 5. Combinatorial chemistry and the synthesis of compound libraries / Rolf Breinbauer and Matthias Mentel -- 6. Ligand-based nuclear magnetic resonance screening techniques / Aldino Viegas, Anjos L. Macedo, and Eurico Cabrita -- 7. Isothermal titration calorimetry and differential scanning calorimetry / Geoff Holdgate -- 8. Adaptive combinatorial design of focused compound libraries / Gisbert Schneider and Andreas Schüller -- 9. Chemical microarrays : a new tool for discovery enzyme inhibitors / Shuguang Liang, Wei Xu, Kurumi Y. Horiuchi, Yuan Wang, and Haiching Ma -- 10. Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays / Kurumi Y. Horiuchi and Haiching Ma -- 11. Small molecule protein interaction profiling with functional protein microarrays / Lihao Meng, Dawn Mattoon, and Paul Predki -- 12. Capillary electrophoresis in drug discovery / Milena Quaglia and Ersilia De Lorenzi -- 13. SPR in drug discovery : searching bioactive compounds in plant extracts / Maria Minunni and Anna Rita Bilia -- 14. Application of frontal affinity chromatography with mass spectrometry (FAC-MS) for stereospecific ligand-macromolecule interaction, detection and screening / Jacek Slon-Usakiewicz and Peter Redden -- 15. GPC spin column HPLC-ESI-MS methods for screening drugs noncovalently bound to proteins / Marshall M. Siegel -- 16. A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening / Yuren Wang and Philip Jones -- 17. A natural products approach to drug discovery : probing modes of action of antitumor agents by genome-scale cDNA library screening / Hendrik Luesch and Pedro Abreu -- 18. Ligand-macromolecule interactions in live cells by fluorescence correlation spectroscopy / Aladdin Pramanik
  • Liposome technology. 3rd ed. v. 1-3, 2007, CRCnetBASE
    v. 2, 2007 CRCnetBASE
    v. 3, 2007 CRCnetBASE
    v. 1. Liposome preparation and related techniques -- v. 2. Entrapment of drugs and other materials into liposomes -- v. 3. Interactions of liposomes with the biological milieu.
  • Managing pharmacy practice 2004, CRCnetBASE
  • Medicinal plants 2012, CRCnetBASE

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