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Pharmacology

  • This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume concentrates on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
  • 1Antibacterial agents --2Antifungal agents --3Antiviral agents --4Antiparasitic agents --5Antiglaucoma agents --6Neuro-ophthalmology --7Anti-inflammatory agents --8Mydriates, cycloplegics, and reversal agents --9Lubricants and viscoelastics --10Miscellaneous conditions --11Anti-angiogenesis agents --12Contact lens.
  • Optimization in drug discovery 2004, Springer Protocols
    pKa, solubility and lipophilicity: assessing physicochemical properties of lead compounds / Yushen Guo and Hong Shen -- Use of caco-2 cell monolayers to study drug absorption and metabolism / Ming Hu ... [et al.] -- Absorption screening using the PAMPA approach / Jeffrey A. Ruell and Alex Avdeef -- In situ single-pass perfused rat intestinal model for absorption and metabolism / Eun Ju Jeong ... [et al.] -- In vitro permeation study with bovine brain microvessel endothelial cells / Sung-Hack Lee ... [et al.] -- An enzymatic microplate assay for testing P-glycoprotein substrates and inhibitors / S. Orlowski, J. Nugier and Eric Ezan -- Evaluation of drug-transporter interactions using in vitro cell models / Yaming Su and Patrick J. Sinko -- Plasma protein-binding methods in drug discovery / Lucinda H. Cohen --Isothermal titration calorimetry characterization of drug-binding energetics to blood proteins / Gary W. Caldwell and Zhengyin Yan -- Metabolic stability assessed by liver microsomes and hepatocytes / David C. Ackley, Kevin T. Rockich, and Timothy R. Baker -- In vitro drug metabolite profiling using hepatic S9 and human liver microsomes / Wu-Nan Wu and Linda A. McKown --In vitro identification of UDP-glucuronosyltransferases involved in drug metabolism / Michael H. Court -- In vitro CYP induction in human hepatocytes / Daniel R. Mudra and Andrew Parkinson -- High-throughput screening of human cytochrome P450 inhibitors using fluorometric substrates: methodology for 25 enzyme/substrate pairs / David M. Stresser -- Evaluation of cytochrome P450 inhibition in human liver microsomes / Zhengyin Yan and Gary W. Caldwell -- Identification of CYP mechanism-based inhibitors / Amin A. Nomeir, Jairam Palamanda, and Leonard Favreau --Detection of DNA adducts by 32P-postlabeling analysis / Naomi Suzuki, Padmaja M. Prabhu, and Shinya Shibutani -- Covalent DNA adduct formation mediated by cytochrome P450 / Marie Stiborová -- Application of in vitro comet assay for genotoxicity testing / Bojana Zegura and Metka Filipic -- Assessing DNA damage using a reporter gene system / Xuming Jia and Wei Xiao -- Improvement of the Ames test using human liver S9 preparation / Atsushi Hakura, Satoshi Suzuki, and Tetsuo Satoh -- Screening for chemical mutagens using the mouse lymphoma assay / Tao Chen and Martha M. Moore -- A high throughput binding assay for HERG / Keith Finlayson and John Sharkey -- In vitro drug metabolism: thiol conjugation / Wei Tang and Randy R. Miller -- In vitro screening assay of the reactivity of acyl glucuronides / Sébastien Bolze.
  • Pasteurella multocida 2012, Springer
    Pasteurella multocida: Diseases and Pathogenesis /I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler --Pathogenomics of Pasteurella multocida /J. D. Boyce, T. Seemann, B. Adler and M. Harper --The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide /Marina Harper, John D. Boyce and Ben Adler --Pasteurella multocida and Immune Cells /Katharina F. Kubatzky --Molecular Biology of Pasteurella multocida Toxin /Joachim H. C. Orth and Klaus Aktories --Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects /Brenda A. Wilson and Mengfei Ho --Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin /Yasuhiko Horiguchi --The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer /Alistair Lax.
  • The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities.
  • Peptide-based drug design 2008, Springer Protocols
    Peptide-based drug design : here and now / Laszlo Otvos, Jr. -- Strategies for the discovery, isolation, and characterization of natural bioactive peptides from the immune system of invertebrates / Philippe Bulet -- Sequence analysis of antimicrobial peptides by tandem mass spectrometry / Christin Stegemann and Ralf Hoffmann -- The spot technique : synthesis and screening of peptide macroarrays on cellulose membranes / Dirk F.H. Winkler and William D. Campbell -- Analysis of A[beta] interactions using ProteinChip technology / Eleni Giannakis ... [et al.] -- NMR in peptide drug development / Jan-Christoph Westermann and David J. Craik -- Molecular dynamics simulations of peptides / Jeffrey Copps, Richard F. Murphy and Sandor Lovas -- Short linear cationic antimicrobial peptides : screening, optimizing, and prediction / Kai Hilpert, Christopher D. Fjell and Artem Cherkasov -- Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach : a tool to identify new bacterial targets amenable to the design of novel antibiotics / Marco Scocchi ... [et al.] -- Serum stability of peptides / Håvard Jenssen and Stein Ivar Aspmo -- Preparation of glycosylated amino acids suitable for Fmoc solid-phase assembly / Mare Cudic and Gayle D. Burstein -- Synthesis of O-phosphopeptides on solid phase / David Singer and Ralf Hoffmann -- Peptidomimetics : Fmoc solid-phase pseudopeptide synthesis / Predrag Cudic and Maciej Stawikowski -- Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines / Brandon Y. Chua, Weiguang Zeng and David C. Jackson -- Synthesis of a multivalent, multiepitope vaccine construct / Laszlo Otvos, Jr. -- Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins / Marina V. Backer ... [et al.].
  • Peptides for youth 2009, Springer
  • Translational medicine: a paradigm shift in modern drug discovery and development: the role of biomarkers / Mark Day, J. Lynn Rutkowski, and Giora Z. Feuerstein -- Natural products in drug discovery: present status and perspectives / Gabriella Molinari -- Protein pharmaceuticals: discovery and preclinical development / Davinder S. Gill -- The role of nanobiotechnology in drug discovery / Kewal K. Jain -- Conotoxin venom peptide therapeutics / Richard J. Lewis -- Shark novel antigen receptors: the next generation of biologic therapeutics? / Caroline Barelle, Davinder Gill, and Keith Charlton -- Immune interventions of human diseases through toll-like receptors / Cevayir Coban, Ken J. Ishii, and Shizuo Akira -- Genome-based vaccine development: a short cut for the future / Danilo Gomes Moriel ... [et al.] -- The antigenome: from protein subunit vaccines to antibody treatments of bacterial infections? / Carmen Giefing, Eszter Nagy, and Alexander von Gabain -- HSV as a vector in vaccine development and gene therapy / Peggy Marconi ... [et al.] -- Virus-like particles as a vaccine delivery system: myths and facts / Polly Roy and Rob Noad -- Applications of bacterial ghosts in biomedicine / Petra Lubitz, Ulrike Beate Mayr, and Werner Lubitz -- Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design / Thomas Ebensen and Carlos A. Guzmøn -- Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS / Aurelio Cafaro ... [et al.] -- New strategies to overcome the drawbacks of currently available flu vaccines / Epifanio Fichera ... [et al.].
  • Contains proceedings of the AAPS Stability Workshop.
  • Pharmaco-complexity 2011, Springer
  • Pharmacogenomics 2005, Springer Protocols
  • Challenges, opportunities, and evolving landscapes in pharmacogenomics and personalized medicine : an industry perspective / Nadine Cohen and Theresa Frangiosa -- Implementation of pharmacogenomic sample collection in clinical trials / Deborah Sokol Ricci and Monique Franc -- Pharmacogenomics : the regulatory environment and labeling implications / Myong-Jin Kim ... [et al.] -- Applications of pharmacogenomics in drug discovery / Duncan McHale -- Applications of pharmacogenomics in clinical trials / Monique Franc -- Pharmacogenomics applications in drug metabolism : from genotyping to drug label-challenges? / Ann K. Daly -- The genetics of adverse drug reactions : promises and problems / Martin Armstrong -- Strategies and resources for marker selection and genotyping in genetic association studies / Nicole Soranzo, Dong-Jing Fu, and Qingqin S. Li -- Study design and statistical issues in pharmacogenetics research : from candidate genes to genome-wide screens / Nicholas J. Schork, Nathalie Malo, and Eric J. Topol -- Holy SNP, Batman! / Reyna Favis -- Predictive biomarker classifiers in the design of pivotal clinical trials / Richard Simon -- Translation of biomarkers into clinical utility / William L. Trepicchio and George Mulligan -- Pharmacogenomic study feasibility assessment and pharmaceutical business decision-making / Monique Franc and Theresa Frangiosa -- Co-development of drugs and pharmacogenomics-based diagnostics in oncology / Jeffrey S. Ross -- Pharmacogenomics applications in epilepsy / Chantal Depondt -- Pharmacogenomics in Alzheimer's disease / Ramón Cacabelos -- Pharmacogenomics applications in psychiatric disorders / Todd Lencz and Anil K. Malhotra -- Pharmacogenomics in HIV disease / Amalio Telenti -- Pharmacogenomics and cardiovascular drugs / Gérard Siest ... [et al.] -- Pharmacogenomic applications in children / Susan F.A. Grant and Hakon Hakonarson -- Pharmacogenomics of rare and monogenic disorders / Paul D. Maher.
  • Pharmacogenomics principles : introduction to personalized medicine / Parvaz Madadi, and Gideon Koren -- Traditional therapeutic drug monitoring and pharmacogenomics : are they complementary? / Christine Snozek, Loralie J. Langman, and Amitava Dasgupta -- Pharmacogenomics aspect of warfarin therapy / Matthew D. Krasowski -- Pharmacogenetics and cancer chemotherapy / Christine L.H. Snozek -- Pharmacogenomic considerations in anesthesia and pain management / Christine Formea, Wayne T. Nicholson -- Pharmacogenomics of immunosuppressants / Nicolas Picard and Pierre Marquet -- Pharmacogenomics of cardiovascular drugs / Linnea M. Baudhuin -- Pharmacogenomics aspect of antiretroviral therapy / Natella Y. Rakhmanina and John N. van den Anker -- Pharmacogenetics of psychoactive drugs / Jorge L. Sepulveda -- Pharmacogenomic aspects of adverse drug-drug interactions / Loralie J. Langman and Christine Snozek -- Microarray technology and other methods in pharmacogenomics testing / Jorge L. Sepulveda -- Pharmacogenetic testing in the clinical laboratory environment / Mark P. Borgman and Mark W. Linder.
  • ch. 1. Physicochemistry -- ch. 2. Pharmacokinetics -- ch. 3. Absorption -- ch. 4. Distribution -- ch. 5. Clearance -- ch. 6 Renal clearance -- ch. 7. Metabolic (hepatic) clearance -- ch. 8. Toxicity -- ch. 9. Inter-species -- ch. 10. High(er) throughput ADME studies.
  • SECTION I. Basic Principles -- Chapter 1. Basic Principles / Ronald D. Schoenwald -- SECTION II. Industrial and Regulatory Applications -- Chapter 2. PK/PD Approach / Honghui Zhou -- Chapter 3. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development / Nishit B. Modi -- Chapter 4. Phase I, II, and III FDA Submissions / Mark G. Eller -- Chapter 5. Bioavailability and Bioequivalence / Veneeta Tandon -- SECTION III. Clinical Applications -- Chapter 6. General Approaches to Clinical Pharmacokinetic Monitoring / Ronald A. Herman -- Chapter 7. Aminoglycosides and Other Antibiotics / Michael E. Klepser and Erika J. Ernst -- Chapter 8. Cardiovascular Agents / John M. Dopp and Bradley G. Phillips -- Chapter 9. Psychotropic Agents / Paul J. Perry -- Chapter 10. Theophylline / Bernd Meibohm -- Chapter 11. Anticonvulsant Agents / Gail D. Anderson -- SECTION IV. Research Applications -- Chapter 12. Classical Modeling / David W A. Bourne -- Chapter 13. Noncompartmental Modeling: An Overview / Ronald A. Herman -- Chapter 14. Physiologically Based Pharmacokinetic Models / James M. Gallo -- Chapter 15. Population Pharmacokinetics / Jeffrey S. Barrett -- Chapter 16. The Linear Systems Approach / Peter Veng-Pedersen -- Index.
  • The natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. --Source other than Library of Congress.
  • Pharmacology 2009, ScienceDirect
  • Pharmacology -- Pharmacokinetic Principles -- Introduction to Specialist Therapeutics.
  • Chapter 1. Pharmacology: The Chemical Control of Physiology -- Chapter 2. Drug Affinity and Efficacy -- Chapter 3. Predicting Agonist Effect -- Chapter 4. Drug Antagonism: Orthosteric Drug Effects -- Chapter 5. Allosteric Drug Effects -- Chapter 6. Enzymes as Drug Targets -- Chapter 7. Pharmacokinetics I: Permeation and Metabolism -- Chapter 8. Pharmacokinetics II: Distribution and Multiple Dosing -- Chapter 9. In Vivo Pharmacology -- Chapter 10. Safety Pharmacology -- Chapter 11. Answers to Chapter Questions -- Chapter 12. Derivations and Proofs.
  • Pharmacology primer. 3rd ed. 2009, ScienceDirect
    What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
  • Definition and classification of pulmonary hypertension / Marc Humbert, David Montani, Oleg V. Evgenov, and Gérald Simonneau -- Pulmonary hypertension: pathophysiology and signaling pathways / Bradley A. Maron and Joseph Loscalzo -- Pulmonary hypertension: pathology / Peter Dorfmüller -- Pulmonary hypertension: biomarkers / Christopher J. Rhodes, John Wharton, and Martin R. Wilkins -- Rodent models of group 1 pulmonary hypertension / John J. Ryan, Glenn Marsboom, and Stephen L. Archer -- General supportive care / Ioana R. Preston -- Calcium-channel blockers in pulmonary arterial hypertension / Marie-Camille Chaumais, Elise Artaud Macari, and Olivier Sitbon -- Prostacyclins / Horst Olschewski -- Endothelin Receptor Antagonists / Martine Clozel, Alessandro Maresta, and Marc Humbert -- Phosphodiesterase-5 inhibitors / Barbara A. Cockrill and Aaron B. Waxman -- Inhaled nitric oxide for the treatment of pulmonary arterial hypertension / Steven H. Abman -- Soluble guanylate cyclase stimulators in pulmonary hypertension / Johannes-Peter Stasch and Oleg V. Evgenov -- Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction / Michael G. Risbano and Mark T. Gladwin -- Rho-kinase inhibitors / Yoshihiro Fukumoto and Hiroaki Shimokawa -- Serotonin transporter and serotonin receptors / Serge Adnot, Amal Houssaini, Shariq Abid, Elisabeth Marcos, and Valérie Amsellem -- Targeting of platelet-derived growth factor signaling in pulmonary arterial hypertension / Eva Berghausen, Henrik ten Freyhaus, and Stephan Rosenkranz -- Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension / Ly Tu and Christophe Guignabert -- Anti-inflammatory and immunosuppressive agents in PAH / Jolyane Meloche, Sébastien Renard, Steeve Provencher, and Sébastien Bonnet -- Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application / Reshma S. Baliga, Raymond J. MacAllister, and Adrian J. Hobbs -- Pulmonary hypertension: novel pathways and emerging therapies inhibitors of cGMP and cAMP metabolism / Yassine Sassi and Jean-Sébastien Hulot -- Pulmonary hypertension: old targets revisited (statins, PPARs, beta-blockers) / Geoffrey Watson, Eduardo Oliver, Lan Zhao, and Martin R. Wilkins -- Pulmonary hypertension: current management and future directions / Lewis J. Rubin.
  • Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).
  • Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).
  • Phytochemicals 2004, CRCnetBASE
    Absorption and metabolism of anthocyanins and other phenolics in human subjects / Ronald L. Prior -- Absorption and metabolism of the dietary phytochemical, quercetin / Gary Williamson -- Pharmacokinetics and bioavailability of green tea catechins / H-H. Sherry Chow -- The importance of in vivo metabolism of polyphenols and their biological action / Stephen Barnes -- Cancer prevention by phytochemicals, modulation of cell cycle / Diane F. Birt -- Cancer chemoprevention by phytopolyphenols including flavanoids and flavonoids through modulating signal transduction pathways / Jen-Kun Lin -- Gene regulation by glucosinolate hydrolysis products / Elizabeth H. Jeffery -- Healthy food vs. phytosterol fortified foods for primary prevention of coronary artery disease / Douglas S. Lewis -- Vascular effects of resveratrol / Joseph M. Wu -- Development of a mixture of dietary carotenoids as cancer chemopreventive agents: C57BL/6J mice as a useful animal model for efficacy studies with carotenoids / Frederick Khachik -- Chemoprevention of colon cancer by curcumin / Bandaru S. Rdddy.
  • Nutritional genomics / Ruan M. Elliott, James R. Bacon, and Yongping Bao -- Methods to study bioavailability of phytochemicals / Birgit Holst and Gary Williamson -- Characterization of polyphenol metabolites /Andrea J. Day, Joseph A. Rothwell, and Michael R.A. Morgan -- Microarray profiling of gene expression patterns of genistein in tumor cells / Ching Li and Biehuoy Shieh -- Gene regulatory activity of Ginkgo biloba L. / Gerald Rimbach, Rainer Cermak, and Siegfried Wolffram -- Cancer chemoprevention with sulforaphane, a dietary isothiocyanate / Yuesheng Zhang -- Phytochemicals protect against heterocyclic amine-induced DNA adduct formation / Yongping Bao and James R. Bacon -- Organosulfur-garlic compounds and cancer prevention / John Milner -- Polymethylated flavonoids: cancer preventive and therapeutic potentials derived from anti-inflammatory and drug metabolism-modifying properties / Akira Murakami and Hajime Ohigashi -- Biochemical and molecular mechanisms of cancer chemoprevention by tea and tea polyphenols / Jen-Kun Lin -- The role of flavonoids in protection against cataract / Julie Sanderson and W. Russell McLauchlan -- Effects of oltipraz on phase 1 and phase 2 xenobiotic-metabolizing enzymes / Sophie Langouet, Fabrice Morel and Andre Guillouzo -- Future perspectives in phytochemical and health research / Yongping Bao and Roger Fenwick.
  • Plant vaccines: an immunological perspective / D.C. Hooper -- Display of peptides on the surface of tobacco mosaic virus particles / M.L. Smith ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality / S. Chebolu and H. Daniell -- Production of antibodies in plants: approaches and perspectives / K. Ko, R. Brodzik and Z. Steplewski -- Plant production of veterinary vaccines and therapeutics / R.W. Hammond and L.G. Nemchinov -- Plant-based oral vaccines: results of human trials / C.O. Tacket.
  • Polymers in drug delivery 2006, CRCnetBASE
  • A. Introduction -- B. Passive or active pharmacovigilance? -- C. Spontaneous reporting -- D. Cohort event monitoring -- E. Data processing -- F. Special types of event -- G. Relationship/causality assessment -- H. Signal identification -- I. Strengthening the signal -- J. Identifying risk factors -- K. Analyses -- L. Differences between spontaneous reporting and cohort event monitoring -- M. Organization -- N. Communication -- Annex.
  • Prodrugs 2007, Springer
  • ch. 1. Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes / Dr. Robert E. Babine, p. 1-46 -- ch. 2. Kinases / Jerry L. Adams, James Veal and Lisa Shewchuk, p. 47-81 -- ch. 3. The Proteasome as a Drug Target / Tsunehiro Mizushima and Tomitake Tsukihara, p. 83-98 -- ch. 4. Antibiotics and the Ribosome / Jeffrey L. Hansen, p. 99-125 -- ch. 5. Structure-Based Design of Cathepsin K Inhibitors / Daniel F. Veber and Maxwell D. Cummings, p. 127-146 -- ch. 6. Structure-Based Design of Potent and Selective Cdk4 Inhibitors / Teruki Honma, p. 147-170 -- ch. 7. Crystallization and Analysis of Serine Proteases with Ecotin / Sandra M. Waugh and Robert J. Fletterick, p. 171-186 -- ch. 8. X-Ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs / Donald F. Doyle and Lauren J. Schwimmer, p. 187-207 -- ch. 9. Engineering Proteins to Promote Crystallization / Lei Jin and Robert E. Babine, p. 209-216 -- ch. 10. High-Throughput Crystallography / Harren Jhoti, p. 217-233 -- ch. 11. Micro-Crystallization / Carl L. Hansen, Morten Sommer, Kyle Self, James M. Berger and Stephen R. Quake, p. 235-255.
  • Establishment of adventitious root cultures of Echinacea purpurea for the production of caffeic acid derivatives / K.Y. Paek, H.N. Murthy and E.J. Hahn -- In vitro propagation of Rauwolfia serpentina using liquid medium, assessment of genetic fidelity of micropropagated plants, and simultaneous quantitation of reserpine, ajmaline, and ajmalicine / M.K. Goel ... [et al.] -- Medicinal properties, in vitro protocols and secondary metabolite analyses of Scots pine / H. Haggman ... [et al.] -- Saussurea medusa cell suspension cultures for flavonoid production / C.Z. Liu and P.K. Saxena -- Large-scale in vitro multiplication of Crataeva nurvala / S.B. Babbar, N. Walia and A. Kaur -- Bilberry in vitro protocols and analyses of phenolic compounds / L. Jaakola ... [et al.] -- In vitro propagation of two tuberous medicinal plants: Holostemma ada-kodien and Ipomoea mauritiana / S.P. Geetha ... [et al.] -- In vitro production of gymnemic acid from Gymnema sylvestre (Retz) R. Br. Ex Roemer and Schultes through callus culture under abiotic stress conditions / A.B. Ali Ahmed, A.S. Rao and M.V. Rao -- Establishment of plant regeneration and cryopreservation system from zygotic embryo-derived embryogenic cell suspension cultures of Ranunculus kazusensis / S.W. Kim and M.J. Oh -- In vitro culture and secondary metabolite isolation in bryophytes / A. Sabovljevic, M. Sabovljevic and N. Jockovic -- Micropropagation and in vitro conservation of vanilla (Vanilla planifolia Andrews) / M. Divakaran and K.N. Babu -- Protocol for in vitro regeneration and marker glycoside assessment in Swertia chirata Buch-Ham / S. Koul ... [et al.] -- Protocols for establishment of an in vitro collection of medicinal plants in the genus Scutellaria / I.B. Cole, F.T. Farooq and S.J. Murch -- Protocols for in vitro culture and phytochemical analysis of Phyllanthus species (Euphorbiaceae) / E. Catapan ... [et al.] -- In vitro clonal propagation of Asparagus racemosus, a high value medicinal plant / S. Saxena and N. Bopana -- Micropropagation of Penthorum chinense through axillary buds / J. Yang and Z.S. Peng -- Spontaneous plant regeneration and production of secondary metabolites from hairy root cultures of Centaurium erythraea Rafn / A. Subotic ... [et al.] -- Transgenic Hypericum perforatum / G. Franklin, M.M. Oliveira and A.C. Dias -- Agrobacterium-mediated transformation of Ruta graveolens L / K. Lievre ... [et al.] -- Gene expression profiling in Taxus baccata L. seedlings and cell cultures / K. Brun akova and J. Kosuth -- Catapol production in Chinese foxglove (Rehmannia glutinosa Libos.) hairy roots transformed with Agrobacterium rhizogenes ATCC15834 / S.J. Hwang -- Identification of medicinal plants and plant sequences: multiplexed MLPA assay / R.A. Barthelson -- Isolation of microsatellites from Catharanthus roseus (L.) G. Don using enriched libraries / S. Bhatia and B. Shokeen -- Production of cinnamyl glycosides in compact callus aggregate cultures of Rhodiola rosea through biotransformation of cinnamyl alcohol / Z. Gyorgy and A. Hohtola -- Spearmint plantlet culture system as a means to study secondary metabolism / B. Tisserat, M. Berhow and S.F. Vaughn -- Bioreactor production of secondary metabolites from cell cultures of periwinkle and sandalwood / J.V. Valluri -- Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species / T. Asano ... [et al.] -- Metabolomic analysis of Ocotea odorifera cell cultures: a model protocol for acquiring metabolite data / M. Maraschin ... [et al.] -- Production of 9-methoxycanthin-6-one from callus cultures of (Eurycoma longifolia Jack) Tongkat Ali / M. Maziah and N. Rosli -- Plant secondary metabolism in altered gravity / L.K. Tuominen, L.H. Levine and M.E. Musgrave -- The role of biotechnology in the production of the anticancer compound podophyllotoxin / H. Lata, C.S. Mizuno and R.M. Moraes.
  • Overview of quantitative drug design -- Noncovalent interactions in biological systems -- Preparation of 3D structures of molecules for 3D QSAR -- Calculating physical properties of molecules -- Biological data -- Form of equations that relate potency and physical properties -- Statistical basis of regression and partial least-squares analysis -- Strategy for the statistical evaluation of a data set of related molecules -- Detailed examples of QSAR calculations on erythromycin esters -- Case studies -- Methods to approach other structure-activity problems.
  • Radiopharmaceuticals 2011, CRCnetBASE
    "This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It examines the relative benefits of various radiopharmaceuticals and provides guidance on dose estimation and agent selection. Utilizing figures of merit for quantitative assessment, it covers standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, vivo methods for obtaining activity data, errors of activity estimation techniques, phantom-based and patient-based dose estimates and their associated uncertainties, and options available to clinical physicists. Supported by numerous examples from clinical trials, it discusses two and three dimensional estimation processes, including modern hybrid scanners such as SPECT/CT and PET/CT"--Provided by publisher.
  • Razoxane and dexrazoxane 2010, Springer
  • Resorcinol 2005, Springer
  • "This book covers the regulatory required evaluation and study of the potentially adverse pharmacological effects of new drugs, from the general regulatory requirements to the specific studies that must be done and how they are performed and interpreted. Based on more than 30 years of direct experience, the author describes tricks and practical insights for making studies work and understanding why they don't. The second edition includes current regulations (US FDA and international especially Europe and Japan) and updated test methods, interpretation, and science"--Provided by publisher.
  • Serotonin and sleep 2008, Springer
  • Serotonin-dopamine interaction 2008, ScienceDirect
  • This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
  • Signals and images 2008, Springer
  • Sphingolipids 2013, Springer
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Sphingolipids in disease 2013, Springer
    Sphingolipids in Cancer.Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance /Shanmugam Panneer Selvam, Besim Ogretmen --Using ASMase Knockout Mice to Model Human Diseases /Guoqiang Hua, Richard Kolesnick --New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer /Susan Pyne, Nigel J. Pyne --Sphingolipids and Response to Chemotherapy /Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard --Lung Cancer and Lung Injury: The Dual Role of Ceramide /Tzipora Goldkorn, Samuel Chung, Simone Filosto --Sphingolipids' Role in Radiotherapy for Prostate Cancer /Carla Hajj, Adriana Haimovitz-Friedman --Sphingolipids in Cardio-Reno-vascular Diseases.Sphingolipid Metabolism and Atherosclerosis /Xian-Cheng Jiang, Jing Liu --Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) /Bodo Levkau --Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease /Pin-Lan Li, Yang Zhang --Sphingolipids in Inflammation, Infection and Lung Diseases.Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity /Taimur Abbasi, Joe G. N. Garcia --Sphingolipids in Acute Lung Injury /Stefan Uhlig, Yang Yang --The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases /Irina Petrache, Daniela N. Petrusca --Ceramide in Cystic Fibrosis /Heike Grassmé, Joachim Riethmüller, Erich Gulbins --Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway /K. Alexa Orr Gandy, Lina M. Obeid --Bacterial Infections and Ceramide /Heike Grassmé, Katrin Anne Becker --Viral Infections and Sphingolipids /Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies --Ceramide in Plasma Membrane Repair /Annette Draeger, Eduard B. Babiychuk --Sphingolipids and Inflammatory Diseases of the Skin /Burkhard Kleuser, Lukasz Japtok --Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease /S. B. Russo, J. S. Ross, L. A. Cowart --Sphingolipids in Neuro-psychiatry and Muscle Diseases.Neuronal Forms of Gaucher Disease /Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation /Laura Davies, Klaus Fassbender, Silke Walter --Sphingolipids in Psychiatric Disorders and Pain Syndromes /C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber --Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology /Paola Bruni, Chiara Donati.
  • Statistics in drug research 2002, CRCnetBASE
  • Superbugs and superdrugs 2008, Wellcome Trust
  • Synthesis of essential drugs 2006, ScienceDirect
  • Basics of Personalized Medicine -- Molecular Diagnostics as Basis of Personalized Medicine -- Role of Biomarkers in Personalized Medicine -- Pharmacogenetics -- Pharmacogenomics -- Role of Pharmacoproteomics -- Role of Metabolomics in Personalized Medicine -- Personalized Biological Therapies -- Development of Personalized Medicine -- Personalized Therapy for Cancer -- Personalized Management of Neurological Disorders -- Personalized Therapy of Cardiovascular Diseases -- Personalized Management of Miscellaneous Disorders -- Personalized Preventive Medicine -- Organization of Personalized Medicine -- Ethical and Regulatory Aspects of Personalized Medicine -- Economics of Personalized Medicine -- Future of Personalized Medicine.
  • Setting up a Kinase Discovery and Development Project /Gideon Bollag --Drug Efficacy Testing in Mice /William Y. Kim, Norman E. Sharpless --Gastrointestinal Stromal Tumors /Cristina Antonescu --EGFR Mutant Lung Cancer /Yixuan Gong, William Pao --Targeting Oncogenic BRAF in Human Cancer /Christine A. Pratilas, Feng Xing, David B. Solit --Beyond BRAF in Melanoma /Adil Daud, Boris C. Bastian --JAK-Mutant Myeloproliferative Neoplasms /Ross L. Levine --Will Kinase Inhibitors Make it as Glioblastoma Drugs? /Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel --Predictive Genomic Biomarkers /Rakesh Kumar, Rafael G. Amado --Epigenetic Biomarkers /Timothy A. Chan, Stephen B. Baylin --Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer /Robert L. Cohen.
  • Thrombin 2009, Springer
  • Toxicologic pathology 2013, CRCnetBASE
    Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.
  • Tumor angiogenesis 2008, Springer
  • Twenty years of G-CSF 2012, Springer
  • Strategies and techniques for bioanalytical assays as part of new drug discovery / Walter A. Korfmacher -- The drug discovery process: from molecules to drugs / Mike S. Lee, Steven E. Klohr -- PK principles and PK/PD applications / Hong Mei, Richard A. Morrison -- Mass spectrometry for in vitro ADME screening / Inhou Chu -- Metabolite identification strategies and procedures / Ragu Ramanathan, S. Nilgün Çömezoǧlu, W. Griffith Humphreys -- Reactive metabolite screening and covalent-binding assays / Gérard Hopfgartner -- Fast metabolite screening in a discovery setting / Xiaoying Xu -- Fast chromatography with UPLC and other techniques / Sam Wainhaus -- Supercritical fluid chromatography-mass spectrometry / Yunsheng Hsieh -- Biomarkers of efficacy and toxicity: discovery and assay / Joanna R. Pols -- Imaging mass spectrometry for small molecules / Fangbiao Li -- MALDI IMS for proteins and biomarkers / Michelle L. Reyzer, Richard M. Caprioli -- Ambient ionization methods and their early applications in ADME studies / Jing-Tao Wu -- Pharmaceutical applications of accelerator mass spectrometry / Lan Gao, Swapan Chowdhury.
  • Vascular endothelium 2006, Springer
    II Springer

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This shortcut (Lane proxy bookmarklet) gives you access to resources licensed by the library even when you're not coming from a Lane or a Stanford IP address.

While we'd like Lane to be your gateway to our licensed content, we recognize that links to books, articles and journals come from a variety of different sources (Google, your email, RSS reader, etc.).

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At the page you would like to proxy, click the "Lane Gateway to Licensed Content" to invoke it.

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This shortcut (Lane proxy bookmarklet) is a combination of a browser bookmark and a JavaScript application. In other words, it's a bookmark that can be programmed to do things. The Lane proxy bookmarklet simply prepends the Lane proxy URL to the current URL in your browser.

This allows you to view the URL as though you were on campus, giving you access to materials licensed for use by the Stanford academic community.

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From the "View" menu, choose "Always Show Bookmarks Bar"

 

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This shortcut (Lane proxy bookmarklet) only works with resources Lane has licensed and configured to work with our proxy server.

If invoked on a resource we do not license and/or have not yet configured, you will see an error message:

The Lane proxy server cannot complete your request because this host has not been configured properly.

We make no attempt to configure our proxy server for every resource, only those we license and for which a Stanford IP address grants access.

Drag this button onto your browser toolbar to install.

  • Right click this button
  • Select "Add to Favorites", click "Continue" if you see a security alert
  • In "Create in" menu, select "Links" (IE7) or "Favorites Bar" (IE8, IE9) to install

Drag this button onto Safari Bookmarks bar to install.

There are 120 high level MeSH Subject Headings under which all MeSH terms fall. Choose a subject heading to see the journals Lane offers in that subject area.

 

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