Lane Medical Library

Pharmacology

• 3D cell-based biosensors in drug discovery programs 2010, CRCnetBASE
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  "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
• A to Z drug facts Ovid
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• AccessMedicine Lange Case files McGraw-Hill
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• Adaptive design methods in clinical trials. 2nd ed. 2012, CRCnetBASE
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  Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
• Adrenergic receptors 2006, Springer
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• Adverse drug reactions 2010, Springer
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  Pt. 1. Target organ toxicity. -- Drug-induced liver injury / Michael Holt, Cynthia Ju.-- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler.-- Adverse drug reactions affecting blood cells / Richard H. Aster.-- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi.-- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb.-- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells, Crystal J.J. Lee, Gordon P. McCallum, Julia Perstin, Patricia A. Harper.-- Pt. II. Mediators/Biochemical pathways.-- Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park.-- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh.-- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park.-- Signal transduction pathways involved in drug-induced liver injury / Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi, Neil Kaplowitz.-- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre, Abdellah Mansouri, Alain Berson, Bernard Fromenty.-- Pt. III. Examples/Models.-- Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James.-- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson.-- Troglitazone / Tsuyoshi Yokoi.-- Neviropine hypersensitivity / M. Popovic, J.M. Shenton, J. Chen, A. Baban, T. Tharmanathan, B. Mannargudi, D. Abdulla, J.P. Uetrecht.-- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke.-- Pt. IV. Risk factors/Screening drug candidates.-- Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed.-- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht.-- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar, Kaushik Mitra, Kelem Kassahun, Thomas A. Baillie.
• Anaesthesia, pharmacology, intensive care and emergency medicine A.P.I.C.E. 2011, Springer
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• Antibiotic discovery and development 2012, Springer
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• Antibiotics 2010, Springer
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• Antibiotics in laboratory medicine. 5th ed. 2005, Ovid
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  The breakpoint / Matthew A. Wikler, Paul G. Ambrose -- Antimicrobial susceptibility on solid media / John D. Turnidge, Jan M. Bell -- Susceptibility testing of antimicrobials in liquid media / Daniel Amsterdam -- Antimicrobial susceptibility testing of anaerobic bacteria / David W. Hecht -- Antimycobacterial agents: in vitro susceptibility testing and mechanisms of action and resistance / Clark B. Inderlied and Kevin A. Nash -- Antifungal drugs: mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids / Michael A. Pfaller, Daniel J. Diekema, and Michael G. Rinaldi -- Antimicrobial susceptibility testing for some atypical microorganisms (chlamydia, mycoplasma, rickettsia, ehrlichia, coxiella, and spirochetes) / Jean-Marc Rolain, Didier Raoult -- Applications, significance of, and methods for the measurement of antimicrobial concentrations in human body fluids / Roger D. Klein and Stephen C. Edberg -- Antimicrobial combinations / Satish K. Pillai, Robert C. Moellering, Jr., and George M. Eliopoulos --Genetic and biochemical mechanisms of bacterial resistance to antimicrobial agents / Louis B. Rice and Robert A. Bonomo -- Molecular methods for the detection of antibacterial resistance genes / Margareta Ieven -- Molecular mechanisms of action for antimicrobial agents: general principles and mechanisms for selected classes of antibiotics / Charles W. Stratton -- The antivirogram and the modes of action of antiviral agents, HIV, hepatitis, influenza, and cytomegalovirus / Pierre Dellamonica ... [et al.] -- Disinfectants and antiseptics, modes of action, mechanisms of resistance, and testing / Joseph M. Ascenzi, Martin S. Favero -- Evaluation of antimicrobials in experimental animal infections / Terry O' Reilly ... [et al.] -- Extravascular antimicrobial distribution and the respective blood and urine concentrations in humans / David M. Bamberger ... [et al.] -- Epidemiology of antimicrobial resistance: species prevalence, susceptibility profiles, and resistance trends / Thomas R. Fritsche, Helio S. Sader, Ronald N. Jones.
• Anticancer agents from natural products 2005, CRCnetBASE
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• Anticancer agents from natural products. 2nd ed. 2012, CRCnetBASE
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  "This book covers clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. The second edition includes drugs that are currently in development. In addition, the text emphasizes the applications of synthetic and medicinal chemistry to the preparation of analogs with enhanced activities. Contributors also address the potential of novel drug discovery through the use of genome mining as well as the status of advanced development candidates. For each compound of class of compounds, the text provides information on the history, structure, mechanism of action, development, synthesis, medicinal chemistry, and clinical applications"-- Provided by publisher."The search for new lead compounds is a crucial element of modern pharmaceutical research. Natural products provided the only source of pharmaceuticals for thousands of years, and natural products have made enormous contributions to human health through compounds such as quinine, morphine, aspirin (a natural product analog), digitoxin, and many others. The potential of natural products as anticancer agents was recognized in the 1950's by the U. S. National Cancer Institute (NCI) under the leadership of the late Dr. Jonathan Hartwell, and the NCI has since made major contributions to the discovery of new naturally occurring anticancer agents through its contract and grant support, including an important program of plant and marine collections. Many, although not all, of the compound classes described in the following pages owe their origin in whole or in part to NCI support. In spite of the success of the natural products approach to anticancer drug discovery, as exemplified by the following chapters, in recent years their importance as a source of molecular diversity for drug discovery research and development has been overshadowed by newer chemical approaches currently in favor. These approaches include chemical ones which make heavy use of combinatorial chemistry, and biological ones such as manipulation of biosynthetic pathways of microbial metabolites through combinatorial biosynthetic techniques. It is thus worthwhile to review briefly the major reasons why natural products are so important. First, there is a strong biological and ecological rationale for plants and marine invertebrates to produce novel bioactive secondary metabolites"-- Provided by publisher.
• Anticoagulants, antiplatelets, and thrombolytics Springer Protocols
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• Antiplatelet agents 2012, Springer
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  Part 1.Pathophysiology.Platelets: Production, Morphology and Ultrastructure /Jonathan N. Thon and Joseph E. Italiano --Platelet Receptors /Alexandre Kauskot and Marc F. Hoylaerts --Platelet Signaling /Timothy J. Stalker, Debra K. Newman, Peisong Ma, Kenneth M. Wannemacher and Lawrence F. Brass --Platelet Interaction with the Vessel Wall /Philip G. de Groot, Rolf T. Urbanus and Mark Roest --Platelets in Atherosclerosis and Thrombosis /Christian Schulz and Steffen Massberg.Part 2.Pharmacology.Aspirin and Other COX-1 Inhibitors /Carlo Patrono and Bianca Rocca --Thienopyridines and Other ADP-Receptor Antagonists /Isabell Bernlochner and Dirk Sibbing --Glycoprotein IIb/IIIa Antagonists /Karen M. Hook and Joel S. Bennett --Targeting Phosphodiesterases in Anti-platelet Therapy /Matthew T. Rondina and Andrew S. Weyrich --PAR-1 Inhibitors: A Novel Class of Antiplatelet Agents for the Treatment of Patients with Atherothrombosis /Sergio Leonardi and Richard C. Becker --Thromboxane Receptors Antagonists and/or Synthase Inhibitors /Giovanni Davì, Francesca Santilli and Natale Vazzana --Inhibitors of the Interaction Between von Willebrand Factor and Platelet GPIb/IX/V /Paolo Gresele and Stefania Momi --Inhibitors of the Interactions Between Collagen and Its Receptors on Platelets /Hans Deckmyn, Simon F. De Meyer, Katleen Broos and Karen Vanhoorelbeke --Intracellular Signaling as a Potential Target for Antiplatelet Therapy /Patrick Andre --Novel Targets for Platelet Inhibition /Kathleen Freson and Chris Van Geet --Variability of Platelet Indices and Function: Acquired and Genetic Factors /Giovanni de Gaetano, Iolanda Santimone, Francesco Gianfagna, Licia Iacoviello and Chiara Cerletti --Small RNAs as Potential Platelet Therapeutics /Leonard C. Edelstein and Paul F. Bray --Pharmacological Modulation of the Inflammatory Actions of Platelets /Richard Amison, Clive Page and Simon Pitchford.Part 3.Therapy.The Role of Laboratory Monitoring in Antiplatelet Therapy /Marco Cattaneo --Antiplatelet Agents in Ischemic Heart Disease /Christopher H. May and A. Michael Lincoff --Antiplatelet Therapy in Cerebrovascular Disorders /Ralph Weber, Johannes Brenck and Hans-Christoph Diener --Antiplatelet Therapy in Peripheral Artery Disease /Francesco Violi, Stefania Basili, Jeffrey S. Berger and William R. Hiatt --Primary Prevention of Ischaemic Cardiovascular Disorders with Antiplatelet Agents /Tom Meade.
• Antisense drug technology. 2nd ed. 2008, CRCnetBASE
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  Mechanisms of antisense drug action, an introduction / Stanley T. Crooke ... [et al.] -- The RNase H mechanism / Walt Lima, Hongjiang Wu, and Stanley T. Crooke -- Small RNA silencing pathways / Alla Sigova and Phillip D. Zamore -- Splice switching oligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, and Ryszard Kole -- Basic principles of antisense drug discovery / Susan M. Freier and Andrew T. Watt -- The medicinal chemistry of oligonucleotides / Eric E. Swayze and Balkrishen Bhat -- Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, and Richard S. Geary -- Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, and Richard S. Geary -- Liposomal formulations for nucleic acid delivery / Ian MacLachlan -- Pharmacological properties of 2'-O-methoxyethyl-modified oligonucleotides / C. Frank Bennett -- Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides in animals and man / Richard S. Geary ... [et al.] -- Toxicologic properties of 2'-O-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry ... [et al.] -- An overview of the clinical safety experience of first- and second-generation antisense oligonucleotides / T. Jesse Kwoh -- Manufacturing and analytical processes for 2'-O-(2-methoxyethyl)-modified oligonucleotides / Daniel C. Capaldi and Anthony N. Scozzari -- Utilizing chemistry to harness RNA interference pathways for therapeutics : chemically modified siRNAs and antagomirs / Muthiah Manoharan and Kallanthottathil G. Rajeev.Discovery and development of RNAi therapeutics / Antonin R. deFougerolles and John M. Maraganore -- Optimization of second-generation antisense drugs: going beyond generation 2.0 / Brett P. Monia ... [et al.] -- Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen -- Locked nucleic acid / Troels Koch and Henrik Ørum -- Morpholinos / Patrick L. Iversen -- Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone and Scott P. Henry -- Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda Baker, and Mark Wedel -- Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot -- Inflammatory diseases / Susan A. Gregory and James G. Karras -- Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik and Martin E. Gleave -- Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith and Timothy M. Miller -- Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jörg Vollmer and Arthur M. Krieg -- Aptamer opportunities and challenges / Charles Wilson.
• Antisense therapeutics. 2nd ed. 2005, Springer Protocols
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  Antisense therapeutics: a promise waiting to be fulfilled / M. Ian Phillips -- Antisense inhibition: oligonucleotides, ribozymes and siRNAs / Y. Clare Zhang ... [et al.] -- Local application of antisense for prevention of restenosis / Patrick L. Iversen ... [et al.] -- Antisense therapeutics for hypertension: targeting the renin-angiotensin system / M. Ian Phillips and Birgitta Kimura -- Antisense strategies for the treatment of heart failure / Sian E. Harding, Federica del Monte, and Roger J. Hajjar -- Clinical studies of antisense oligonucleotides for cancer therapy / Rosanne M. Orr and F. Andrew Dorr -- Antisense therapy in clinical oncology: preclinical and clinical experiences / Ingo Tamm -- Radionucleide-peptide nucleic acid diagnosis and treatment of pancreatic cancer / Eric Wickstrom ... [et al.] -- Suppression of pancreatic and colon cancer cells by antisense K-ras RNA expression vectors / Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida -- Induction of tumor cell apoptosis and chemosensitization by antisense strategies / Manuel Rieber and Mary Strasberg-Rieber -- Utility of an anti-oncogene ribozymes and antisense oligonucletoides in reversing drug resistance / Tadao Funato -- Transport of antisense across the blood-brain barrier / Laura B. Jaeger and William A. Banks -- Transdermal delivery of antisense oligonucletoides / Rhonda M. Brand and Patrick L. Iversen -- Antisense strategies for redirection of drug metabolism: using paclitaxel as a model / Vikram Arora -- Antisense oligonucletoide treatment of inflammatory bowel diseases / Bruce R. Yacyshyn -- Optimizing electroporation conditions for the intracellular delivery of morpholino antisense oligonucleotides directed against the hepatitis C virus internal ribosome entry site / Ronald Jubin.
• Antiviral strategies 2009, Springer
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• Appetite control 2012, Springer
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• Application of peptide-based prodrug chemistry in drug development 2013, Springer
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• Approaches to the conformational analysis of biopharmaceuticals 2010, CRCnetBASE
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  Introduction to biopharmaceutical conformational analysis : issues and methods -- Comparability of biotechnological/biological products and biological generics -- Application of native electrophoresis for the study of protein conformation -- Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation -- Size-exclusion chromatography and bimolecular conformation -- Use of analytical ultracentrifugation to study biomolecular conformation -- Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules -- Light scattering and biomacromolecular conformation -- Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products -- Near-infrared spectroscopy and macromolecular conformation -- Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules -- Use of Raman spectroscopy to evaluate biopharmaceutical conformation -- The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products -- Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation -- Use of nuclear magnetic resonance for the characterization of biotherapeutic products -- Use of chemical probes for the study of protein conformation -- Use of hydrogen exchange in the study of biopharmaceutical conformation -- Use of chemical modification for the conformational analysis of biopharmaceuticals -- Use of immunology to characterize biopharmaceutical conformation -- Use of limited proteolysis to study the conformation of proteins of biotechnological interest -- Other technologies for the characterization of conformational change in biopharmaceuticals -- Development of an experimental approach for the study of the conformation of a biological therapeutic product.
• Appropriate dose selection 2007, Springer
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• Aspirin and related drugs 2004, CRCnetBASE
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• Bacterial resistance to antimicrobials. 2nd ed. 2008, CRCnetBASE
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  Microbial drug resistance: a historical perspective / William C. Summers -- Ecology of antibiotic resistance genes / Abigail A. Salyers, Nadja Shoemaker, and David Schlesinger -- Global response systems that confer resistance / Paul F. Miller and Philip N. Rather -- Multidrug efflux pumps: structure, mechanism, and inhibition / Olga Lomovskaya ... [et al.] -- Mechanisms of aminoglycoside antibiotic resistance / Gerard D. Wright -- Resistance to [beta]-lactam antibiotics mediated by [beta]-lactamases : structure, mechanism, and evolution / Jooyoung Cha, Lakshmi P. Kotra, and Shahriar Mobashery -- Target modification as a mechanism of antimicrobial resistance / David C. Hooper -- Antibiotic permeability / Harry Taber -- Genetic methods for detecting bacterial resistance genes / Ad C. Fluit --Evolution and epidemiology of antibiotic-resistant pneumococci / Christopher Gerard Dowson and Krzysztof Trzcinski -- Antimicrobial resistance in the enterococcus / George M. Eliopoulos -- Methicillin resistance in staphylococcus aureus / Keeta S. Gilmore, Michael S. Gilmore, and Daniel F. Sahm -- Mechanism of drug resistance in mycobacterium tuberculosis / Alex S. Pym and Stewart T. Cole -- Antibiotic resistance in enterobacteria / Nafsika H. Georgopapadakou -- Resistance as a worldwide problem / Paul Shears -- Public health responses to antimicrobial resistance in outpatient and inpatient settings / Cindy R. Friedman and Arjun Srinivasan -- Antibacterial drug discovery in the 21st century / Steven J. Projan.
• Bacteriocins 2007, Springer
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• Basic & clinical pharmacology 2012 (12th ed.)., AccessMedicine
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• Bioanalytical separations 2003, ScienceDirect
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  New developments in integrated sample preparation for bioanalysis / M.W.J. van Hout, H.A.G. Niederländer, R.A. de Zeeuw and G.J. de Jong -- Solid-phase extraction on molecularly imprinted polymers / Lars I. Andersson and Leif Schweitz -- Techniques for sample preparation using solid-phase extraction / Uwe Dieter Neue, Claude R.Mallet, Ziling Lu, Yung-Fong Cheng and Jeffrey R. Mazzeo -- Turbulent flow chromatography in bioanalysis / Tony Edge -- Chiral bioanalysis / D.M. Wallworth and J.T. Lee -- Method development in reversed-phase chromatography / Uwe Dieter Neue, Eric S. Grumbach, Jeff R. Mazzeo, KimVan Tran and Diane M. Wagrowski-Diehl -- Immobilized enzyme reactors in liquid chromatography : on-line bioreactors for use in synthesis and drug discovery / Nektaria Markoglou and Irving W. Wainer -- Use of liquid chromatography-mass spectrometry in acute human toxicology / M.J. Bogusz -- HPLC-MS(MS) for bioanalysis in drug discovery and development / Brian Law -- Biomedical applications of directly-coupled chromatography : nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) / John C. Lindon, Nigel J.C. Bailey, Jeremy K. Nicholson and Ian D. Wilson -- Ultra-sensitive detection of radiolabelled drugs and their metabolites using accelerator mass spectrometry / Graham Lappin and R. Colin Garner -- Biomedical applications of inductively coupled plasma mass spectrometry (ICP-MS) as an element specific detector for chromatographic separations / Fadi R. Abou-Shakra -- Chromatography in a regulated environment / H.M. Hill.
• Biochemical targets of plant bioactive compounds 2003, CRCnetBASE
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  Plant defensive compounds and their biochemical targets -- Introduction -- Organization and scope of the book -- Description of the tables -- Using the tables -- The structural diversity of plant defensive compounds -- Plant alkaloids -- Plant phenolics -- Plant terpenes -- Other plant compounds -- Biochemistry: the chemistry of life -- Introduction: water-based life -- Protein structure -- Enzymes and ligand-binding proteins -- Metabolic strategies -- Inhibition of biochemical processes by plant defensive compounds -- Neurotransmitter- and hormone-gated ion channels -- Introduction: electrical signalling in excitable cells -- Ionotropic neurotransmitter receptors: neurotransmitter-gated ion channels -- Structure and function of ionotropic receptors -- Ion pumps, ligand- and voltage-gated ion channels -- Introduction -- Ion pumps -- Voltage-gated Na⁺ channels -- Ligand-regulated and voltage-gated K⁺ channels -- Voltage-gated Ca²⁺ channels -- Ligand-gated Ca²⁺ channels -- Chloride transport and voltage-regulated chloride channels.
• Biocombinatorial approaches for drug finding 2005, Springer
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• Bioequivalence and statistics in clinical pharmacology 2006, CRCnetBASE
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• Bioinformatics and drug discovery Springer Protocols
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  New strategies in drug discovery / Eliot H. Ohlstein ... [et al.] -- Basic microarray analysis: strategies for successful experiments / Scott A. Ness -- From microarray to biological networks: analysis of gene expression profiles / Xiwei Wu and T. Gregory Dewey -- Microarray analysis in drug discovery and clinical applications / Siqun Wang and Qiong Cheng -- Ontology-driven approaches to analyzing data in functional genomics / Francisco Azuje, Fatima Al-Shahrour, and Joaquin Dopazo -- Gene evolution and drug discovery / James O. McInerney ... [et al.] -- Standardization of microarray and pharmacogenomics data / Cassey S. Husser ... [et al.] -- Clinical applications of bioinformatics, genomics, and pharmacogenomics / Omer Iqbal and Jawed Fareed --Protein interactions probed with mass spectrometry / Suma Kaveti and John R. Engen -- Discovering new drug targeting sites on flexible multidomain protein kinases -- combining segmental isotopic and site-directed spin labeling for nuclear magnetic resonance dectection of interfacial clefts / Thomas K. Harris -- Nuclear magnetic resonance-based screening methods for drug discovery / Laurel O. Sillerud and Richard S. Larson -- Receptor binding sites: bioinformatic approaches / Darren R. Flower -- In silico protein design: fitting sequence onto structure / Bassil I. Dahiyat -- Chemical database preparation for compound acquisition or virtual screening / Cristian G. Bologa, Marius M. Olah, and Tudor I. Oprea -- Bioinformatics platform development: from gene to lead compound / Alexis S. Ivanov ... [et al.].
• Biologics in general medicine 2007, Springer
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• Biology of marijuana 2002, CRCnetBASE
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• Biomarker methods in drug discovery and development 2008, Springer
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• Biomaterials for delivery and targeting of proteins and nucleic acids 2005, CRCnetBASE
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• BioNMR in drug research 2003, Wiley
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  Pending
• Biopharmaceutics applications in drug development 2008, Springer
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• Biosimulation in biomedical research, health care, and drug development 2012, Springer
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• Burger's Medicinal chemistry and drug discovery. 7th ed. / 2010, Wiley
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  "... provides an established, recognized, authoritative and comprehensive source on medicinal chemistry and drug discovery and development. This flagship reference for medicinal chemists and pharmaceutical professions has been thoroughly updated and expanded across 8 volumes to incorporate the entire process of drug development (preclinical testing, clinical trials, etc.) alongside the traditional strengths in medicinal chemistry and drug discovery"--Provided by publisher.
• Caffeine and activation theory 2007, CRCnetBASE
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• Calcium signaling protocols. 2nd ed. 2005, Springer Protocols
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  Fluorescent measurement of [Ca²+]c: basic practical considerations / Alec W.M. Simpson -- Measurement of [Ca²+]i in whole cell suspensions using fura-2 / Robert A. Hirst ... [et al.] -- Measurement of [Ca²+]i in cell suspensions using indo-1 / Adriaan Nelemans -- Confocal microscopy: theory and applications for cellular signaling / Stephen C. Tovey, Paul J. Brighton, and Gary B. Willars -- Single-cell and subcellular measurement of intracellular Ca²+ concentration / Anthony J. Morgan and Andrew P. Thomas -- Ratiometric Ca²+ measurements using the FlexStation scanning fluorometer / Ian C.B. Marshall, Izzy Boyfield, and Shaun McNulty -- Measuring Ca²+ changes in multiwell format using the fluorometric imaging plate reader / Ian C.B. Marshall, Davina E. Owen, and Shaun McNulty --Measurement of Ca²+ entry using cells ⁴⁵Ca²+ / Mercedes Villarroya ... [et al.] -- Measurement of [³H]PN200-110 and [¹²⁵I]-conotoxin MVIIA binding / Kazuyoshi Hirota and David G. Lambert -- Whole-cell patch clamp recording of voltage-sensitive Ca²+ channel currents: heterologous expression systems and dissociated brain neurons / Atticus H. Hainsworth, Andrew D. Randall, and Alessandro Stefani -- Measurement of phospholipase C by monitoring inositol phosphates using [³H]inositol-labeling protocols in permeabilized cells / Alison Skippen, Philip Swigart, and Shamshad Cockcroft -- Measurement of inositol(1,4,5)triphosphate using a stereospecific radioreceptor mass assay / Darren Smart --Measurement of calcium fluxes in permeabilized cells using a ⁴⁵Ca²+ uptake and release assay / Robert A. Wilcox -- Microinjection of myo-inositol(1,4,5)trisphosphate and other calcium-mobilizing agents into intact adherent cells / Robert A. Wilcox, Ian D. Forsythe, and Terence J. McCann -- Measurement of free [Ca²+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators / Aldebaran M. Hofer -- Measurement of [Ca²+]i in smooth muscle strips using front-surface fluorimetry / Hideo Kanaide -- Measurement of calcium and movement in heart cells / Leong L. Ng and Paulene A. Quinn --Simultaneous analysis of intracellular pH and Ca²+ from cell populations / Raul Martinez-Zaguilan ... [et al.] -- Measurement of cytosolic-free Ca²+ in plant tissue / Martin R. McAinsh and Carl K.-Y. Ng -- Assay and purification of calmodulin-dependent protein kinase / Rajendra K. Sharma -- Assay and purification of calmodulin-dependent cyclic nucleotide phosphodiesterase and isozyme separation / Rajendra K. Sharma -- Measurement of Ca²+-ATPase activity (in PMCA and SERCA1) / Danuta Kosk-Kosicka.
• Cannabinoid receptors 2009, Springer
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• Cannabinoids 2005, Springer
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• Cannabinoids and the brain 2008, Springer
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• Cannabinoids as therapeutics 2005, Springer
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• Capillary electrophoresis methods for pharmaceutical analysis. 1st ed. 2008, ScienceDirect
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  Overview of Capillary Electrophoresis in Pharmaceutical Analysis -- Theoretical Consideration in Performance of Various Modes of CE -- Equipment Considerations for Capillary Electrophoresis -- Method Development for Pharmaceutical Analysis -- Role of CE in Drug Substance and Drug Product Development -- General Considerations to Improve Performance of CE Methods -- Overview of Current Regulatory Guidance -- Qualification of CE Instrumentation -- Robustness Testing of CE Methods -- Validation of Analytical Methods Using Capillary Electrophoresis-- The Need for CE Methods in Pharmacopeial Monographs -- CE in Impurity Profiling of Drugs -- Ion Analysis Using Capillary Electrophoresis -- Role of CE in Biopharmaceutical Development and Quality Control -- Capillary Electrophoresis and Bioanalysis -- CE as an Orthogonal Technique to Chromatography -- Capillary Electrochromatography of Pharmaceuticals -- Coupling CE and Chip-based Devices and Mass Spectrometry.
• Carbohydrate-based drug discovery 2003, Wiley
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  ch. 1. Synthetic methodologies / Chikako Saotome, Osamu Kanie -- ch. 2. Complex carbohydrate synthesis / Makoto Kiso, Hideharu Ishida, Hiromune Ando -- ch. 3. The chemistry of sialic acid / Geert-Jan Boons, Alexei V. Demchenko -- ch. 4. Solid-phase oligosaccharide synthesis / Peter H. Seeberger -- ch. 5. Solution and polymer-supported synthesis of carbohydrates / Shin-Ichiro Nishimura -- ch. 6. Enzymatic synthesis of oligosaccharides / Jianbo Zhang, Jun Shao, Prezemk Kowal, Peng George Wang -- ch. 7. Glycopeptides and glycoproteins : synthetic chemistry and biology / Oliver Seitz -- ch. 8. Synthesis of complex carbohydrates : Everninomicin 13,384-1 / K. C. Nicolaou, Helen J. Mitchell, Scott A. Snyder -- ch. 9. Chemical synthesis of asparagine-linked glycoprotein oligosaccharides : recent examples / Yukishige Ito, Ichiro Matsuo -- ch. 10. Chemistry and biochemistry of asparagine-linked protein glycosylation / Barbara Imperiali, Vincent W.-F. Tai -- ch. 11. Conformational analysis of C-glycosides and related compounds : programming conformational profiles of C- and O-glycosides / Peter G. Goekjian, Alexander Wei, Yoshito Kishi -- ch. 12. Synthetic lipid A antagonists for sepsis treatment / William J. Christ, Lynn D. Hawkins, Michael D. Lewis, Yoshito Kishi -- ch. 13. Polysialic acid vaccines / Harold J. Jennings -- ch. 14. Synthetic carbohydrate-based vaccines / Stacy J. Keding, Samuel J. Danishefsky -- ch. 15. Chemistry, biochemistry, and pharmaceutical potentials of glycosaminoglycans and related saccharides / Tasneem Islam, Robert J. Linhardt -- ch. 16. A new generation of antithrombotics based on synthetic oligosaccharides / Maurice Petitou, Jean-Marc Herbert -- ch. 17. Sequencing of oligosaccharides and glycoproteins / Stuart M. Haslam, Kay-Hooi Khoo, Anne Dell -- ch. 18. Preparation of heterocyclic 2-deoxystreptamine aminoglycoside analogues and characterization of their interaction with RNAs by use of electrospray ionization mass spectrometry / Richard H. Griffey, Steven A. Hofstadler, Eric E. Swayze -- ch. 19. Glycosylation analysis of a recombinant P-selectin antagonist by high-pH anion-exchange chromatography with pulsed electrochemical detection (HPAEC/PED) / Mark R. Hardy, Richard J. Cornell -- ch. 20. Analytical techniques for the characterization and sequencing of glycosaminoglycans / Ram Sasisekharan, Zachary Shriver, Mallik Sundaram, Ganesh Venkataraman -- ch. 21. Thermodynamic models of the multivalency effect / Pavel I. Kitov, David R. Bundle -- ch. 22. Synthetic multivalent carbohydrate ligands as effectors or inhibitors of biological processes / Laura L. Kiessling, Jason K. Pontrello, Michael C. Schuster -- ch. 23. Glycosyltransferase inhibitors / Karl-Heinz Jung, Richard R. Schmidt -- ch. 24. RNA-aminoglycoside interactions / Haim Weizman, Yitzhak Tor -- ch. 25. Glycosylated natural products / Jon S. Thorson, Thomas Vogt -- ch. 26. Novel enzymatic mechanisms in the biosynthesis of unusual sugars / Alexander Wong, Xuemei He, Hung-Wen Liu -- ch. 27. Neoglycolipids : identification of functional carbohydrate epitopes / Ten Feizi, Alexander M. Lawson, Wengang Chai -- ch. 28. A preamble to aglycone reconstruction for membrane-presented glycolipid mimics / Murugesapillai Mylvaganam, Clifford A. Lingwood -- ch. 29. Small molecule inhibitors of the sulfotransferases / Dawn E. Verdugo, Lars C. Pedersen, Carolyn R. Bertozzi -- ch. 30. Carbohydrate-based treatment of cancer metastasis / Reiji Kannagi -- ch. 31. N-acetylneuraminic acid derivatives and mimetics as anti-influenza agents / Robin Thomson, Mark Von Itzstein -- ch. 32. Modified and modifying sugars as a new tool for the development of therapeutic agents : the biochemically engineered N-acyl side chain of sialic acid : biological implications and possible uses in medicine / Rüdiger Horstkorte, Oliver T. Keppler, Werner Reutter -- ch.33 . Modified and modifying sugars as a new tool for the development of therapeutic agents : glycosidated phospholipids as a new type of antiproliferative agents / Kerstin Danker, Annette Fischer, Werner Reutter -- ch. 34. Glycoside primers and inhibitors of glycosylation / Jillian R. Brown, Mark M. Fuster, Jeffrey D. Esko -- ch. 35. Carbohydrate-based drug discovery in the battle against bacterial infections : new opportunities arising from programmable one-pot oligosaccharide synthesis / Thomas K. Ritter, Prof. Dr. Chi-Huey Wong.
• Cardiac drug development guide 2003, Springer Protocols
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• Caveolins in cancer pathogenesis, prevention and therapy 2012, Springer
  Lane Catalog record
• Cell signaling & molecular targets in cancer 2012, Springer
  Lane Catalog record
• Cell-penetrating peptides 2002, CRCnetBASE
  Lane Catalog record
• Challenges for the FDA NAP
  Lane Catalog record
• Chemical and pharmaceutical industry in China 2005, Springer
  Lane Catalog record
• Chemistry and pharmacology of anticancer drugs 2006, CRCnetBASE
  Lane Catalog record
  Introduction to cancer -- Antimetabolites -- DNA-interactive agents -- Antitubulin agents -- Cell signaling inhibitors -- Hormonal therapies -- Tumour targeting strategies -- Biologicals -- The future -- Personalized medicine (oncogenomics) -- Adjunct therapies.
• Chemoinformatics Springer Protocols
  Lane Catalog record
• Chemokine receptors 2007, Springer
  Lane Catalog record
• Chinese and related North American herbs 2002, CRCnetBASE
  Lane Catalog record
• Chiral separations Springer Protocols
  Lane Catalog record
• Chirality in drug design and development 2004, CRCnetBASE
  Lane Catalog record
• Clinical pharmacology and therapy of Helicobacter pylori infection 2004., Karger
  Lane Catalog record
• Clinical pharmacology of sleep 2006, Springer
  Lane Catalog record
• Clinical trials in the neurosciences 2009., Karger
  Lane Catalog record
• Co-existence and co-release of classical neurotransmitters 2009, Springer
  Lane Catalog record
• Colloids in drug delivery 2010, CRCnetBASE
  Lane Catalog record
  Surfactants and block copolymers in drug delivery / Ambikanandan Misra ... [et al.] -- Application of colloidal properties in drug delivery / Swarnlata Saraf -- Polymeric nanocapsules for drug delivery : an overview / Sílvia S. Guterres ... [et al.] -- Poly(alkyl cyanoacrylate) nanoparticles for drug delivery and vaccine development / Anja Graf, Karen Krauel-Göllner, Thomas Rades -- Stimuli-sensitive polymer gels for dermal and transdermal drug delivery and their application in the development of smart textile materials / Witold Musial and Vanja Kokol -- Micelles : the multifunctional nanocarrier for colloidal drug delivery / Chandana Mohanty, Sarbari Acharya, and Sanjeeb K. Sahoo -- Multiple emulsions : an overview and pharmaceutical applications / Jatin Khurana, Somnath Singh, and Alekha K. Dash -- Pharmaceutical and biotechnological applications of multiple emulsions / Rita Cortesi and Elisabetta Esposito -- Nanoemulsions as drug delivery systems / Figen Tirnaksiz, Seyda Akkus, and Nevin Celebi -- Microemulsion systems : application in delivery of poorly soluble drugs / Ljiljana Djekic and Marija Primorac -- Diclofenac solubilization in mixed nonionic surfactants microemulsions / Monzer Fanun -- Self-emulsifying drug delivery systems / D. P. Maurya, Yasmin Sultana, and M. Abul Kalam -- Liquid crystals and their application in the field of drug delivery / Rakesh Patel and Tanmay N. Patel -- Liquid crystalline nanoparticles as drug nanocarriers / Anan Yaghmur and Michael Rappolt -- Niosomal delivery system for macromolecular drugs / Yongzhuo Huang, Faquan Yu, and Wenquan Liang -- A new class of mesoscopic aggregates as a novel drug delivery system / Federico Bordi, Cesare Cametti, and Simona Sennato -- Liposomes and biomacromolecules : effects of preparation protocol on in vitro activity / Paola Luciani, Debora Berti, and Piero Baglioni -- Colloidal nanocarrier systems as a tool for improving antimycobacterial and antitumor activities and reducing the toxicity of usnic acid / N. S. Santos-Magalhães ... [et al.] -- Dendrimers in drug delivery / Hu Yang -- Microsphere : a novel drug delivery system / Abdus Samad ... [et al.] -- Colloids in aerosol drug delivery system / Nazrul Islam -- Respiratory aerosol dynamics with applications to pharmaceutical drug delivery / Jinxiang Xi, P. Worth Longest, and Paula J. Anderson -- Colloidal carriers for drug delivery in dental tissue engineering / Nader Kalaji, Nida Sheibat-Othman, and Hatem Fessi -- Classification and application of colloidal drug delivery systems : passive or active tumor targeting / H. Yesim Karasulu, Burcak Karaca, and Ercüment Karasulu -- Nanocarriers for imaging applications / Vandana Patravale and Medha Joshi.
• Color atlas of pharmacology. 3rd ed., rev. and expanded. 2005, Thieme Book
  Lane Catalog record
  Antithrombotics -- Plasma volume expanders -- Drugs used in hyperlipoproteinemias -- Diuretics -- Drugs for the treatment of peptic ulcers -- Laxatives -- Antidiarrheals -- Drugs acting on motor systems -- Drugs for the suppression of pain -- Antipyretic analgesics -- Local anesthetics -- Nonsteroidal anti-inflammatory drugs -- Local anesthetics -- Opioids -- General anesthetics -- Psychopharmacologicals -- Hormones -- Antibacterial drugs -- Antifungal drugs -- Antiviral drugs -- Antiparasitic agents -- Anticancer drugs -- Immune modulators -- Antidotes -- Therapy of selected diseases.History of pharmacology -- Drug sources -- Drug development -- Drug administration -- Cellular sites of action -- Distribution in the body -- Drug elimination -- Pharmacokinetics -- Quantification of drug action -- Drug-receptor interaction -- Adverse drug effects -- Genetic variation of drug effects -- Pharmacogenetics -- Drug-independent effects -- Drugs acting on the sympathetic nervous system -- Drugs acting on the parasympathetic nervous system -- Nicotine -- Biogenic amines -- Vasodilators -- Inhibitors of the renin-angiotensin-aldosterone system -- Drugs acting on smooth muscle -- Cardiac drugs -- Antianemics --
• Comprehensive medicinal chemistry II ScienceDirect
  Lane Catalog record
  v. 1. Global perspective / volume editor, Peter D. Kennewell -- v. 2. Strategy and drug research / volume editor, Walter H. Moos -- v. 3. Drug discovery technologies / volume editor, Hugo Kubinyi -- v. 4. Computer-assisted drug design / volume editor, Jonathan S. Mason -- v. 5. ADME-Tox approaches / volume editors, Bernard Testa and Han van de Waterbeemd -- v. 6. Therapeutics areas I: central nervous system, pain, metabolic syndrome, urology, gastrointestinal and cardiovascular / volume editor, Michael Williams -- v. 7. Therapeutic areas II: cancer, infectious diseases, inflammation & immunology and dermatology / volume editors, Jacob J. Plattner & Manoj C. Desai -- v. 8. Case histories and cumulative subject index / volume editors, John B. Taylor & David J. Triggle.
• Computational pharmacokinetics 2008, CRCnetBASE
  Lane Catalog record
  Empirical pharmacokinetics -- Numerical methods for PK parameter estimation -- Physiological aspects on pharmacokinetics -- Modelling the distribution process -- PK/PD modelling.
• Current protocols in pharmacology Wiley
  Lane Catalog record
• Cyclooxygenases 2008, Springer Protocols
  Lane Catalog record
  Part I. In vitro protocols for studying expression and activity of cyclooxygenase enzymes and characterisation of their inhibition patterns -- 1. In vitro cyclo-oxygenase expression and activity protocols : introduction to Part I / Roderick J. Flower -- 2. Techniques used to study regulation of cyclooxygenase-2 promoter sites / Hiroyasu Inoue and Rieko Nakata -- 3. Purification of recombinant human COX-1 and COX-2 / James K. Gierse -- 4. Cloning and expression of cyclooxygenase-1 and cyclooxygenase-2 / Nicholas R. Staten and Beverly A. Reitz -- 5. Expression of cyclooxygenase isoforms in the baculovirus expression system / John C. Hunter, Natalie M. Myres, and Daniel L. Simmons -- 6. Peroxidase active site activity assay / Kelsey C. Duggan, Joel Musee, and Lawrence J. Marnett -- 7. Study of inhibitors of the PGH synthases for which potency Is regulated by the redox state of the enzymes / Olivier Boutaud and John A. Oates -- 8. Different methods for testing potential cyclooxygenase-1 and cyclooxygenase-2 inhibitors / Stefan Laufer and Sabine Luik -- 9. In vitro cyclooxygenase activity assay in tissue homogenates / Samir S. Ayoub -- 10. Techniques used to characterize the binding of cyclooxygenase Inhibitors to the cyclooxygenase active site / William F. Hood -- 11. In vitro Assays for cyclooxygenase activity and inhibitor characterization / Mark C. Walker and James K. Gierse -- -- Part II. Extraction and measurement of prostanoids and isoprostanes -- 12. Extraction and measurement of prostanoids and isoprostanes : introduction to Part II / Paola Patrignani -- 13. Prostanoid extraction and measurement / Lorenzo Polenzani and Samir S. Ayoub -- 14. Measurement of 8-iso-prostaglandin F2a in biological fluids as a measure of lipid peroxidation / Stefania Tacconelli, Marta L. Capone, and Paola Patrignani -- -- Part III. In vivo models to study involvement of cyclooxygenase products in health and disease -- 15. In vivo models to study cyclooxygenase products in health and disease: introduction to Part III / Derek W. Gilroy, Melanie Stables, and Justine Newson -- 16. Protocols to assess the gastrointestinal side effects resulting from inhibition of Cyclo-Oxygenase isoforms / Brendan J.R. Whittle -- 17. Cyclooxygenase enzymes and their products in the carrageenan-induced pleurisy in rats / Adrian R. Moore, Samir S. Ayoub, and Michael P. Seed -- 18. Iloprost-induced nociception : determination of the site of anti-nociceptive action of cyclooxygenase inhibitors and the Involvement of cyclooxygenase products in central mechanisms of nociception / Samir S. Ayoub and Regina M. Botting.
• Dermal absorption models in toxicology and pharmacology 2005, CRCnetBASE
  Lane Catalog record
• Desk reference of clinical pharmacology. 2nd ed. 2008, CRCnetBASE
  Lane Catalog record
  The pharmacokinetic basis of therapeutics -- The pharmacodynamic basis of therapeutics -- Adverse reactions and drug-drug interactions -- Herb-drug interactions -- Food-drug interactions.
• Developing a national registry of pharmacologic and biologic clinical trials NAP
  Lane Catalog record
• Development of antibody-based therapeutics 2012, Springer
  Lane Catalog record
  Translational Strategies for Development of Antibody-Based Therapeutics: An Overview /Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp --Discovery Process for Antibody-Based Therapeutics /Heather H. Shih --Technologies for the Generation of Human Antibodies /Ramesh R. Bhatt, John S. Haurum and C. Geoffrey Davis --Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics /Randall J. Brezski and Juan Carlos Almagro --Biophysical Considerations for Development of Antibody-Based Therapeutics /Andrew W. Drake and Giuseppe A. Papalia --Considerations in Establishing Affinity Design Goals for Development of Antibody-Based Therapeutics /Mohammad Tabrizi --Bioanalytical Considerations for Development of Antibody-Based Therapeutics: Pharmacokinetics and Immunogenicity /Cherryl B. Funelas and Scott L. Klakamp --Preclinical Considerations for Development of Antibody-Based Therapeutics in Oncology /Gregory Landes and Kathleen Elias --Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology /David C. Blakey.Preclinical Safety Considerations for the Development of Antibody-Based Therapeutics /Lolke de Haan --Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therapeutics /Donald E. Mager --Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics /Feng Jin --Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics /Mohammad A. Tabrizi and Cherryl B. Funelas --Translational Research in Alzheimer's Disease for Development of Antibody-Based Therapeutics /Eric C. Yuen, Enchi Liu and Gene G. Kinney --Considerations in Manufacturing Process Development for Antibody-Based Therapeutics /Paula C. Miller and Peiling Xu --Strategies for Development of Next Generation Antibody-Based Therapeutics /Mohammad Tabrizi and Gadi Gazit Bornstein --Immune Complex Therapies for Treatment of Immune Thrombocytopenia /Rong Deng and Joseph P. Balthasar --Application of Bioinformatics Principles for Target Evaluation /Anthony Carvalloza, Mohammad Fallahi and Sahba Tabrizifard --Concluding Remarks /Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp.
• DNA topoisomerases and cancer 2012, Springer
  Lane Catalog record
  Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina ... [et al.] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev ... [et al.] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir ... [et al.] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico ... [et al.] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer ... [et al.] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss ... [et al.] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier.
• Dopamine 2005, ScienceDirect
  Lane Catalog record
• Dopamine receptors. 2nd ed. 2010, Springer
  Lane Catalog record
• Dose finding by the continual reassessment method 2011, CRCnetBASE
  Lane Catalog record
  Part I. Fundamentals -- Chapter 1. Introduction -- Chapter 2. Dose Finding in Clinical Trials -- Chapter 3. The Continual Reassessment Method -- Chapter 4. One-Parameter Dose-Toxicity Models -- Chapter 5. Theoretical Properties -- Chapter 6. Empirical Properties -- Part II. Design Calibration -- Chapter 7. Specifications of a CRM Design -- Chapter 8. Initial Guesses of Toxicity Probabilities -- Chapter 9. Least Informative Normal Prior -- Chapter 10. Initial Design -- Part III. CRM and Beyond -- Chapter 11. The Time-to-Event CRM -- Chapter 12. CRM with Multiparameter Models -- Chapter 13. When the CRM Fails -- Chapter 14. Stochastic Approximation.
• Drug absorption studies 2008, Springer
  Lane Catalog record
• Drug and biological development 2007, Springer
  Lane Catalog record
• Drug delivery systems 2008, Springer Protocols
  Lane Catalog record
  Drug delivery systems--an overview / Kewal K. Jain -- The role of the adeno-associated virus capsid in gene transfer / Kim M. Van Vliet ... [et al.] -- Delivering small interfering RNA for novel therapeutics / Patrick Y. Lu and Martin C. Woodle -- Catheters for chronic administration of drugs into brain tissue / Michael Guarnieri, Benjamin S. Carson, Sr., and George I. Jallo -- Transdermal drug delivery systems : skin perturbation devices / Marc B. Brown ... [et al.] -- Controlling the release of proteins/peptides via the pulmonary route / Sunday A. Shoyele -- Engineering protein particles for pulmonary drug delivery / Sunday A. Shoyele -- 2B-Trans technology : targeted drug delivery across the blood-brain barrier / Pieter J. Gaillard and Albertus G. de Boer -- Drug delivery in cancer using liposomes / Crispin R. Dass -- pH-responsive nanoparticles for cancer drug deliery / Youqing Shen ... [et al.] -- Extended-release oral drug delivery technologies : monolithic matrix systems / Sandip B. Tiwari and Ali R. Rajabi-Siahboomi.
• Drug delivery systems. 2nd ed. 2004, CRCnetBASE
  Lane Catalog record
• Drug discovery and evaluation 2006, Springer
  Lane Catalog record
  Section I, Safety pharmacology: -- Introduction to safety pharmacology -- Status of safety pharmacology and present guidelines -- Central nervous system (CNS) safety pharmacology studies -- Methods in cardiovascular safety pharmacology -- Safety pharmacology of drugs for the urinary tract -- Respiratory function assays in safety pharmacology -- Metabolism pharmacology -- Peripheral nervous system -- Safety of intravenous and inhalation anesthetics -- Side effects of central analgesic drugs -- Safety pharmacology of antiinflammatory drugs -- Safety pharmacology of drugs with osteoarthritis-related activity -- Safety pharmacology of blood constituents -- Ocular toxicity tests -- Assays in endocrine safety pharmacology -- Safety assays in skin pharmacology -- Magnetic resonance imaging in pharmaceutical safety assessment --Section II, Safety pharmacokinetics: -- Introduction -- Physicochemical properties -- In-silico ADME modeling -- Absorption-in vitro tests-cell based -- Absorption-in vitro tests-non cell based -- Distribution-in vitro tests-protein binding -- Perfused organs -- Metabolism studies in vitro and in vivo -- Distribution-across barriers -- Drug-drug interaction-enzyme induction -- Drug-drug interaction-enzyme inhibition -- Absorption -- In vivo distribution -- Distribution-in vivo-other methods -- Bioanalytical assays-Toxicokinetics -- Bioanalytical assays-liquid chromatography coupled to tandem spectrometry -- Bioanalytical assays-gas chromatography -- Bioanalytical assays-RIA/EIA -- Clinical studies-typical designs -- Pharmacogenomics in DME -- Typical PK/PD approaches -- Population kinetics in drug development --Section III, Safety toxicology: -- Introduction -- International guidelines for the development of pharmaceutical compounds -- General toxicity -- In silico methods -- Alternative methods for carcinogenicity testing -- Genotoxicity -- Reproductive toxicology -- Application of toxicoproteomics in profiling drug effects.
• Drug discovery and evaluation. 3rd completely rev., updated, and enl. ed. 2008, Springer
  Lane Catalog record
• Drug interactions in infectious diseases. 3rd ed. 2011, Springer
  Lane Catalog record
  Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Interactions Between Herbs and Antiinfective Medications -- Drug-Cytokine Interactions -- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions with Antiretrovirals for HIV Infection -- Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelmintic Agents -- Drug Interaction Considerations Throughout Drug Development -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.
• Drug metabolism 2005, Springer
  Lane Catalog record
• Drug metabolism and pharmacokinetics quick guide 2011, Springer
  Lane Catalog record
• Drug metabolism and transport 2005, Springer Protocols
  Lane Catalog record
  Renal cytochrome P450s and flavin-containing monooxygenases : potential roles in metabolism and toxicity of 1,3-butadiene, trichloroethylene, and tetrachloroethylene / Adnan A. Elfarra -- Experimental approaches for the study of cytochrome P450 gene regulation / Hollie I. Swanson ... [et al.] -- Insulin and growth factor signaling : effects on drug metabolizing enzymes / Sang K. Kim, Kimberly J. Woodcroft, and Raymond F. Novak -- Catalytic function and expression of glutathione transferase zeta / Philip G. Board, M.W. Anders, and Anneke C. Blackburn -- Glucuronidation of fatty acids and prostaglandins by human udp glucuronosyltransferases / Anna Radominska-Pandya, Joanne M. Little and Arthur Bull -- Transcriptional regulation of UDP-glucuronosyltransferases / Anna Radominska-Pandya, Peter I. Mackenzie, and Wen Xie -- Phenotypic and genotypic characterization of n-acetylation / Craig K. Svensson and David W. Hein -- Methods and approaches to study metabolism and toxicity of acetaminophen / Sam A. Bruschi -- Modulation of drug metabolism and antiviral therapies / Bernhard H. Lauterburg -- Modulation of thiols and other low-molecular-weight cofactors : effects on drug metabolism and disease susceptibility / Charles V. Smith -- Multidrug resistance proteins and hepatic transport of endo- and xenobiotics / Phillip M. Gerk and Mary Vore -- Structural determinants of folate and antifolate membrane transport by the reduced folate carrier / Wei Cao and Larry H. Matherly -- Glutathione transport in the kidneys : experimental models, mechanisms, and methods / Lawrence H. Lash -- Human cytosolic sulfotransferases : properties, physiological functions, and toxicology / Charles N. Falany.
• Drug monitoring and clinical chemistry 2004, ScienceDirect
  Lane Catalog record
• Drug product development for the back of the eye 2011, Springer
  Lane Catalog record
• Drug residues in foods 2001, CRCnetBASE
  Lane Catalog record
• Drug resistance in cancer cells 2009, Springer
  Lane Catalog record
  Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakács ... [et al.] -- Metastasis and Drug Resistance / Dominic Fan ... [et al.] -- The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama ... [et al.] -- Mechanisms of Resistance to targeted Tyrosine Kinase Inhibitors / Stacey J.Baker, E. Premkumar Reddy -- Targeting Transglutaminase-2 to overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- Extracellular Matrix-Mediated Drug Resistance / P.S. Hodkinson, Tariq Sethi -- Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- Nuclear Factor-kB and Chemoresistance / Ajaikumar B.Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- Drug Resistance and the Tumor Suppressor p53 : The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- Resistance to Differentiation Therapy / Bulent Ozpolat -- MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong.
• Drug safety evaluation 2009, Springer Protocols
  Lane Catalog record
  Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
• Drug transporters 2011, Springer
  Lane Catalog record
• Drug-related problems in the elderly 2009, Springer
  Lane Catalog record
• Drugs compromising male sexual health 2008, Springer
  Lane Catalog record
  Male sexual health -- Structure and physiology of the testis -- Introduction -- The spermatozoa -- Sperm motility -- Capacitation and acrosome reaction -- Fertilization of the oocyte -- Testing substances that compromise spermatogenesis and fertility (adapted from Creasy 1997) -- Testosterone production and testosterone effects -- Physiology of erection -- Introduction -- Role of androgens in erection -- Priapism -- Physiology of ejaculation -- Drugs which compromise male sexual health -- Adverse drug effects -- Male sexual health and drugs -- Drugs which compromise testicular function -- Drugs which compromise erectile function -- Drugs which compromise ejaculation -- Database of drugs.
• Drugs in pregnancy and lactation. 9th ed. 2011, Ovid
  Lane Catalog record
• Emerging safety science 2008, NAP
  Lane Catalog record
  1. Introduction -- 2. Investigative Toxicology: The State of the Art -- 3. Screening Technologies I: Human Cell-Based Approaches -- 4. Screening Technologies II: Toxicogenomics -- 5. Screening Technologies III: Metabolomics -- 6. Screening Technologies IV: Pharmacogenetics -- 7. Qualifying Biomarkers -- 8. Pharmacovigilance -- 9. Integration -- 10. The Future of Safety Science.
• Enzyme- and transporter-based drug-drug interactions 2010, Springer
  Lane Catalog record
• Ethnomedicine and drug discovery 2002, ScienceDirect
  Lane Catalog record
  Therapeutic agents from ethnomedicine / Maurice M Iwu -- Drugs from nature : past achievements, future prospects / Gordon M Cragg and David J Newman -- Natural products for high-throughput screening / Alan L Harvey -- Medical ethnobotanical research as a method to identify bioactive plants to treat infectious diseases / Thomas JS Carlson -- Development of HerbMed : an interactive, evidence-based herbal database / Jacqueline C Wootton -- Natural products : a continuing source of inspiration for the medicinal chemist / S Mbua Ngale Efange -- Integrating African ethnomedicine into primary healthcare : a framework for south-eastern Nigeria / Chioma Obijiofor -- Current initiatives in the protection of indigenous and local community knowledge : problems, concepts and lessons for the future / Robert Lettington -- Bioprospecting : using Africa's genetic resources as a new basis for economic development and regional cooperation / Anthony Onugu -- Balancing conservation with utilization : restoring populations of commercially valuable medicinal herbs in forests and agroforests / Richard A Cech -- Ethnomedicine of the Cherokee : historical and current applications / Jody E Noé --Traditional medicines and the new paradigm of psychotropic drug action / Elaine Elisabetsky -- Drug discovery through ethnobotany in Nigeria : some results / Joseph I Okogun --Plants, products and people : southern African perspectives / Nigel Gericke -- Development of antimalarial agents and drugs for parasitic infections based on leads from traditional medicine : the Walter Reed experience / Brian G Schuster -- Health foods in anti-aging therapy : reducers of physiological decline and degenerative diseases / Lisa Meserole -- Indigenous peoples and local communities embodying traditional lifestyles : definitions under Article 8 (j) of the Convention on Biological Diversity / Katy Moran -- Garcinia kola : a new look at an old adaptogenic agent / Maurice M Iwu, Angela Duncan Diop, Lisa Meserole and Chris O Okunji -- Linking intellectual property rights with traditional medicine / Michael A Gollin -- The use of conservation trust funds for sharing financial benefits in bioprospecting projects / Marianne Guerin-McManus, Kent C Nnadozie and Sarah A Laird -- The regulation of botanicals as drugs and dietary supplements in Europe / Joerg Gruenwald -- Regulation of herbal medicines in Nigeria : the role of the National Agency for Food and Drug Administration and Control (NAFDAC) / Gabriel E Osuide -- Considerations in the development of public standards for botanicals and their dosage forms / V Srini Srinivasan -- The Belize Ethnobotany Project : safeguarding medicinal plants and traditional knowledge in Belize / Michael J Balick, Rosita Arvigo, Gregory Shropshire, Jay Walker, David Campbell and Leopoldo Romero -- Ethnobotanical research into the 21st century / Susan Tarka Nelson-Harrison, Steven R King, Charles Limbach, Carey Jackson, Andrew Galiwango, Sirimani Kisingi Kato and BR Kanyerezi -- Ethnobotanical approach to pharmaceutical drug discovery : strengths and limitations / Maurice M Iwu.
• Ethnopharmacology of medicinal plants 2006, Springer
  Lane Catalog record
  Anti-Inflammatory Plants -- Plants Affecting the Central Nervous System -- Plants for Chemotherapy of Neoplastic Diseases.
• FDA administrative enforcement manual 2005, CRCnetBASE
  Lane Catalog record