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Pathology and Laboratory Medicine

  • 1. Sentinel Lymph Nodes -- 2. Assessment of the Surgical Margins -- 3. Diagnostic Evaluation of a Breast Mass -- 4. Handling of Specimens with a Nonpalpable Lesion -- 5. Core Needle Biopsies -- 6. Regulatory Requirements for Breast Specimens.
  • Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
  • This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology .
  • Nonneoplastic diseases of the prostate / Kiril Trpkov -- Neoplastic diseases of the prostate / Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the urinary bladder / Fang-Ming Deng, Jonathan Melamed -- Neoplasms of the urinary bladder / Jesse K. McKenney, Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Ming Zhou, Eyas M. Hattab, John N. Eble, Liang Cheng -- Introduction to renal biopsy / Laura Barisoni, Lois J. Arend, David B. Thomas -- Diseases of the ureter and renal pelvis / Ximing J. Yang -- Diseases of penis, urethra, and scrotum / Rajal B. Shah -- Nonneoplastic diseases of the testis / Cristina Magi-Galluzzi, Howard S. Levin -- Neoplasms of the testis / Charles C. Guo.
  • Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist?s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
  • This volume provides a compact, concise and up-to-date resource for pathologists and clinicians who are involved in women's health. The book summarizes the incidence, epidemiology and risk factors for cervical adenocarcinoma, while reviewing the normal histology of the cervix and glandular lesions of the cervix. The cytological appearance of glandular lesions of the cervix and their mimics is amply illustrated and discussed. Management of glandular lesions is also outlined. Written by authorities in the field, Glandular Lesions of the Uterine Cervix: Cytopathology with Histologic Correlates is of great value to cytopathologists, surgical pathologists, gynecologic oncologists and surgeons.
  • 1. Silver Stains for the Identification of Neuroendocrine Cell Types / L. Grimelius -- 2. Autometallographic Tracing of Gold, Silver, Bismuth, Mercury, and Zinc / G. Danscher, G. W. Hacker, and M. Stoltenberg -- 3. Silver- and Gold-Based Autometallography of Nanogold / J.E Hainfeld and R.D. Powell -- 4. Immunogold-Silver Staining for Light Microscopy Using Colloidal or Clustered Gold (Nanogold) / G.W. Hacker, A.L.M. Cheung, R.R. Tubbs, L. Grimelius, G. Danscher, and C. Hauser-Kronberger -- 5. The Protein A-Gold-Silver Staining Method / O. Fujimori -- 6. Microscopic Uses of Nanogold® / J.E Hainfeld, R.D. Powell, and FR. Furuya -- 7. Combined Fluorescent and Gold Probes for Microscopic and Morphological Investigations / R.D. Powell and J. Hainfeld -- 8. Detection of Human Papillomavirus by In Situ Hybridization Using an In Situ PCR Thermal Cycler / P. Jackson and F.A. Lewis -- 9. Supersensitive In Situ Hybridization by Tyramide Signal Amplification and Nanogold® Silver Staining: The Contribution of Autometallography and Catalyzed Reporter Deposition to the Rejuvenation of In Situ Hybridization / R.R. Tubbs, J. Pettay, T. Grogan, A.L.M. Cheung, R.D. Powell, J. Hainfeld, C. Hauser-Kronberger, and G.W. Hacker -- 10. Immunogold Labeling Techniques for Transmission Electron Microscopy: Applications in Cell and Molecular Biology / L. Lossi, P Aimar, E. Beltramo, and A. Merighi -- 11. Pre-Embedding Immunoelectron Microscopy with Nanogold® Immunolabeling, Silver Enhancement, and Its Stabilization by Gold / H. Sawada and M. Esaki -- 12. Gold Cluster Immunoprobes: Light and Electron Microscopy / J.M. Robinson, T. Takizawa, and D.D. Vandré -- 13. Highly Sensitive Ultrastructural Immunogold Detection Using Tyramide and Gold Enhancement / C. Schöfer and K. Weipoltshammer -- 14. In Situ Hybridization at the Electron Microscopic Level / C. Schöfer and K. Weipoltshammer -- 15. Immunogold-Silver Staining for Scanning Electron Microscopy in Cancer Research / B.-L. Wang, N. Flay, and G.W. Hacker -- 16. Immunogold-Silver Scanning Electron Microscopy Using Glycerol Liquid Substitution / J. Šamaj, H.-J. Ensikat, W. Barthlott, and D. Volkmann.
  • 1. Detection and analysis of proteins -- 2. Detection and analysis of nucleic acids -- 3. Recombinant DNA techniques: cloning and manipulation of DNA -- 4. Antibody-based techniques -- 5. Microscopy: imaging of biological specimens -- 6. The derivation and manipulation of experimental animals in biomedical sciences.
  • Autopsy protocol -- Opinion reports -- Other reports -- Style -- Death certification -- Record retention.
  • Autopsy techniques and procedures -- Ensuring quality in the hospital autopsy -- Principles of dissection -- Cardiovascular system -- Nervous system -- Eye and adnexa -- Autopsy laboratory -- Autopsy microbiology -- Autopsy chemistry -- Chromosome analysis of autopsy tissue -- Postmortem imaging techniques -- Autopsies of bodies containing radioactive materials -- The hospital autopsy report, death certification -- Medicolegal autopsy and postmortem toxicology -- Legal aspects of autopsy practice -- Fixation and transport of autopsy material -- Museum techniques.
  • "This pathophysiology handbook is ideally suited for easy reference in the classroom or clinical environment. The book presents a summary of physiology concepts for each body system, followed by an overview of important pathophysiology concepts related to 'alterations' in that body system. These pathophysiology concepts provide the necessary foundation for understanding the disease or injury states that are presented next in the chapter"--Provided by publisher.
  • General principles -- Pediatric autopsy: fetus, newborn, and child -- Examination of the human embryo -- The placenta -- Hydrops -- Chromosomal defects -- Congenital abnormalities -- Cardiovascular system -- Respiratory system -- Gastrointestinal system -- Liver, gallbladder, biliary tract, and pancreas -- Renal system -- Male and female genitourinary systems -- Central nervous system -- Thymus, spleen, lymph nodes, and immunodeficiency -- Skeletal system -- The eye and adnexa sectioning -- Metabolic diseases -- Sudden infant death -- Pediatric forensic pathology -- Special procedures -- Infection control and biological hazards in the autopsy.
  • Pathologists have long recognized that pediatric autopsy requires great care in technique and dissection to ensure that easily overlooked malformations are recognized and accurate diagnoses are made. The highly experienced authors have created a new edition of Handbook of Pediatric Autopsy Pathology, a comprehensive reference guide to the actual performance of the pediatric autopsy and the optimal recognition and interpretation of pathologic findings. The Handbook of Pediatric Autopsy Pathology, Second Edition covers the spectrum of pediatric pathology with particular reference to those conditions that can be identified at autopsy. New and updated material includes microbiological studies, particularly with the advent of newly described micro-organisms causing disease. The volume also addresses new developments in metabolic diseases, new techniques of ultrasound imaging, and specialized laboratory testing. Furthermore, the book provides a wealth of practical information and bibliographic citations throughout, new copious illustrations and line drawings, numerous standard reference tables, and appendices at the end of multiple chapters. Authored by authorities in the field, Handbook of Pediatric Autopsy Pathology, Second Edition is a valuable resource that will assist general and pediatric pathologists, neonatologists, interns and residents in training, as well as specialists in cytogenetics and ultrasound technicians in understanding the manner and cause of death in its broadest and comprehensive sense.
  • 2013 ClinicalKey
  • 2013 ClinicalKey
    "Part of the popular Foundations in Diagnostic Pathology Series, Head and Neck Pathology delivers vital diagnostic guidance in a compact, high-yield format. Concise and easy to use, this pathology reference offers a practical, well-organized approach to evaluating a wide range of specimens in both head and neck and related endocrine pathology. Easily review normal histology before examining abnormal findings so you can avoid false positives. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Apply the latest diagnostic criteria for all of the most commonly seen neoplastic and non-neoplastic conditions of the larynx, hypopharynx, and trachea; nasal cavity, paranasal sinuses, and nasopharynx; oral cavity and oropharynx; salivary glands; ear; and temporal bone. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Quickly reference key information with convenient, at-a-glance clinical and pathologic boxes throughout."--Summary of the editor.
  • Hematopathology 2013
    ClinicalKey
  • Hematopathology. 1st ed. 2011
    ClinicalKey
    Pt. 1. Technical aspects: Processing of the lymph node biopsy specimen -- Fine-needle aspiration of lymph nodes -- Collection, processing, and examination of bone marrow specimens -- Immunohistochemistry for the hematopathology laboratory -- Flow cytometry -- Molecular diagnosis in hematopathology -- Cytogenetic analysis and related techniques in hematopathology -- Pt. 2. Normal and reactive conditions of hematopoietic tissues -- Normal lymphoid organs and tissues -- The reactive lymphadenopathies -- The normal bone marrow -- Evaluation of anemia, leukopenia, and thrombocytopenia -- Bone marrow findings in inflammatory, infectious, and metabolic disorders -- Pt. 3. Lymphoid neoplasms -- Principles of classification of lymphoid neoplasms -- section 1. Mature B-cell neoplasms -- Mature B-cell neoplasms: chronic lymphpcytic leukemia-small lymphocytic lymphoma, B-cell prolymphocytic leukemia, and lymphoplasmacytic lymphoma -- Hairy cell leukemia -- Splenic marginal zone lymphoma -- Follicular lymphoma -- Extranodal marginal zone lymphoma: MALT lymphoma -- Primary cutaneous B-cell lymphoma -- Nodal marginal zone lymphoma -- Mantle cell lymphoma -- Diffuse large B-cell lymphoma -- Lymphomatoid granulomatosis -- Burkitt's lymphoma -- Plasma cell neoplasms -- Nodular lymphocyte-predominant type of Hodgkin's lymphoma -- Classical Hodgkin's lymphoma -- section 2. Mature T-cell and NK-cell neoplasms -- NK-cell neoplasms -- Epstein-Barr virus - positive systemic T-lymphoproliferative disorders and related lymphoproliferations of childhood -- T-cell large granular lymphocytic leukemia -- T-cell prolymphocytic leukemia -- Adult T-cell leukemia/lymphoma -- Hepatosplenic T-cell lymphoma -- Peripheral T-cell lymphoma, not otherwise specified -- Angioimmunoblastic T-cell lymphoma -- Anaplastic large cell lymphoma, ALK positive and ALK negative -- Enteropathy-associated T-cell lymphoma and other primary intestinal T-cell lymphomas -- Mycosis fungoides and Sezary syndrome -- Primary cutaneous CD30-positive T-cell lymphoproliferative disorders-- Primary cutaneous T-cell lymphomas: rare subtypes -- section 3. Precursor B- and T-cell neoplasms -- Precursor B- and T-cell neoplasms -- Acute leukemias of ambiguous lineage -- Pt. 4. Myeloid neoplasms -- Principles of classification of myeloid neoplasms -- The myelodysplastic syndromes -- Acute myeloid leukemia -- Myeloproliferative neoplasms -- Myelodysplastic/Myeloproliferative neoplasms -- Mastocytosis -- Eosinophilia and chronic eosinophilic leukemia, including myeloid/lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 -- Blastic plasmacytoid dendritic cell neoplasm -- Pt. 5. Histiocytic proliferations -- Nonneoplastic histiocytic proliferations of lymph nodes and bone marrow -- Langerhans cell histiocytosis and Langerhans cell sarcoma -- Other histiocytic and dendritic cell neoplasms -- Pt. 6. Immunodeficiency disorders -- The pathology of primary immunodeficiencies -- Iatrogenic immunodeficiency-associated lymphoproliferative disorders -- Hematopathology of Human Immunodeficiency Virus (HIV) infection -- Pt. 7. Site-specific issues in the diagnosis of lymphoma and leukemia -- Bone marrow evaluation for lymphoma -- Evaluation of the bone marrow after therapy -- Nonhematopoietic neoplasms of the bone marrow -- Nonlymphoid lesions of the lymph nodes -- Spleen: normal architecture and neoplastic and nonneoplastic lesions -- Diagnosis of lymphoma in extranodal sites other than skin -- Appendix: Staining techniques.
  • Print Material
    Blood platelets and Von Willebrand Disease -- Laboratory approach to thrombotic risk -- Antithrombotic therapy -- Overview of the immune system and immunologic disorders -- Immunoassays and immunochemistry -- Laboratory evaluation of the cellular immune system -- Laboratory evaluation of immunoglobin function and humoral immunity -- Mediators of inflammation: complement, cytokines, and adhesion molecules -- Human leukocyte antigen: the major histocompatibility complex of man -- The major histocompatibility complex and disease -- Immunodeficiency disorders -- Clinical and laboratory evaluation of systemic rheumatic diseases -- Vasculitis -- Organ-specific autoimmune diseases -- Allergic diseases -- Viral infections -- Chlamydial, rickettsial, and mycoplasmal infections -- Medical bacteriology -- In vitro testing of antimicrobial agents -- Spirochete infections -- Mycobacteria -- Mycotic diseases -- Medical parasitology -- Molecular pathology of infectious diseases -- Specimen collection and handling for diagnosis of infectious diseases -- Bioterrorism: microbiology -- Introduction to molecular pathology -- Molecular diagnostics: basic principles and techniques -- Polymerase chain reaction and other chain reaction amplification technology -- Hybridization array technologies -- Applications of cytogenetics in modern pathology -- Establishing a molecular diagnostics laboratory -- Molecular diagnosis of hematopoietic neoplasms -- Molecular diagnosis of genetic diseases -- Identity analysis: use of DNA polymorphisms in parentage and forensic testing -- Diagnostic and management of cancer using serologic tumor markers -- Oncoproteins and early tumor detection -- Diagnostic and prognostic impact of high-throughput genomic and proteomic technologies in the post-genomic era. General concepts and administrative issues -- Optimizing laboratory workflow and performance -- Pre-analysis -- Analysis: principles of instrumentation -- Analysis: clinical laboratory automation -- Point-of-care and physician office laboratories -- Post-analysis: medical decision-making -- Interpreting laboratory results -- Laboratory statistics -- Quality control -- Clinical laboratory informatics -- Financial management -- Biological, chemical and nuclear terrorism: role of the laboratory -- Evaluation of renal function, water, electrolytes and acid-base balance -- Biochemical markers of bone metabolism -- Carbohydrates -- Lipids and dyslipoproteinemia -- Evaluation of cardiac injury and function -- Specific proteins -- Clinical enzymology -- Evaluation of liver function -- Laboratory diagnosis of gastrointestinal and pancreatic disorders -- Toxicology and therapeutic drug monitoring -- Evaluation of endocrine function -- Reproductive function and pregnancy -- Vitamins and trace elements -- Basic examination of urine -- Cerebrospinal, synovial, and serous body fluids -- Basic examination of blood and bone marrow -- Hematopoiesis -- Erythrocytic disorders -- Leukocytic disorders -- The flow cytometric evaluation of hematopoietic neoplasia -- Immunohematology -- Transfusion medicine -- Hemapheresis -- Tissue banking and progenitor cells -- Coagulation and fibrinolysis --
  • Pt. 1. The clinical laboratory. -- General concepts and administrative issues -- Optimizing laboratory workflow and performance -- Pre-analysis -- Analysis: principles of instrumentation -- Analysis: clinical laboratory automation -- Point-of-care and physician office laboratories -- Post-analysis: medical decision-making -- Interpreting laboratory results -- Laboratory statistics -- Quality control -- Clinical laboratory informatics -- Financial management -- Biological, chemical and nuclear terrorism: role of the laboratory -- Pt. 2. Clinical chemistry. -- Evaluation of renal function, water, electrolytes and acid-base balance -- Biochemical markers of bone metabolism -- Carbohydrates -- Lipids and dyslipoproteinemia -- Cardiac injury, atherosclerosis, and thrombotic disease -- Specific proteins -- Clinical enzymology -- Evaluation of liver function -- Laboratory diagnosis of gastrointestinal and pancreatic disorders -- Toxicology and therapeutic drug monitoring -- Evaluation of endocrine function -- Reproductive function and pregnancy -- Vitamins and trace elements -- Chemical basis for analyte assays and common interferences -- Pt. 3. Urine and other body fluids. -- Basic examination of urine -- Cerebrospinal, synovial, and serous body fluids -- Pt. 4. Hematology, coagulation, and transfusion medicine. -- Basic examination of blood and bone marrow -- Hematopoiesis -- Erythrocytic disorders -- Leukocytic disorders -- The flow cytometric evaluation of hematopoietic neoplasia -- Immunohematology -- Transfusion medicine -- Hemapheresis -- Tissue banking and progenitor cells -- Pt. 5. Hemostasis and thrombosis. -- Coagulation and fibrinolysis -- Blood platelets and Von Willebrand Disease -- Laboratory approach to thrombotic risk -- Antithrombotic therapy -- Pt. 6. Immunology and immunopathology. -- Overview of the immune system and immunologic disorders -- Immunoassays and immunochemistry -- Laboratory evaluation of the cellular immune system -- Laboratory evaluation of immunoglobin function and humoral immunity -- Mediators of inflammation: complement, cytokines, and adhesion molecules -- Human leukocyte antigen: the major histocompatibility complex of man -- The major histocompatibility complex and disease -- Immunodeficiency disorders -- Clinical and laboratory evaluation of systemic rheumatic diseases -- Vasculitis -- Organ-specific autoimmune diseases -- Allergic diseases -- Pt. 7. Medical microbiology. -- Viral infections -- Chlamydial, rickettsial, and mycoplasmal infections -- Medical bacteriology -- In vitro testing of antimicrobial agents -- Spirochete infections -- Mycobacteria -- Mycotic diseases -- Medical parasitology -- Specimen collection and handling for diagnosis of infectious diseases -- Pt. 8. Molecular pathology. -- Introduction to molecular pathology -- Molecular diagnostics: basic principles and techniques -- Polymerase chain reaction and other chain reaction amplification technology -- Hybridization array technologies -- Applications of cytogenetics in modern pathology -- Establishing a molecular diagnostics laboratory -- Molecular diagnosis of genetic diseases -- Identity analysis: use of DNA polymorphisms in parentage and forensic testing -- Pharmacogenomics and personalized medicine -- Pt. 9. Clinical pathology of cancer -- Diagnostic and management of cancer using serologic tumor markers -- Oncoproteins and early tumor detection -- Molecular diagnosis of hematopoietic neoplasms -- Molecular genetic pathology of solid tumors -- High-throughput genomic and proteomic technologies in the post-genomic era -- Appendix 1. Physiologic solutions, buffers, acid-base indicators, standard reference materials, and temperature conversions -- Appendix 3. Desirable weights, body surface area, and body mass index (BMI) -- Appendix 1. Approximations of total blood volume (TBV) -- Appendix 4. Periodic table of the elements -- Appendix 5. SI units -- Appendix 6. Common chimeric genes identified in human malignancies -- Appendix 7. Disease/organ panels -- Guidelines for ordering blood for elective surgery
  • Over the past 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes the most diagnostic challenges and problems for general pathologists. Among the reasons for this are the relative rarity of salivary gland tumors (as a result of which the general pathologist does not gain sufficient personal experience in their diagnosis), their striking diversity (there are almost 40 different histological tumor entities), and the fact that some tumours dedifferentiate and some benign tumors progress to become malignant. This book is a comprehensive guide to salivary gland pathology that illustrates almost every type of salivary gland tumor and will assist greatly in routine diagnostic work. Non-neoplastic lesions, benign epithelial tumors, malignant epithelial tumors, and non-epithelial and secondary tumors are all covered in detail, and the WHO and TNM classifications are clearly explained. Another significant feature is the incorporation of important knowledge gained during the past few years regarding the genetics of salivary gland tumors. Histopathology of the Salivary Glands will be of interest not only to pathologists but also to dentists, ENT and head and neck surgeons, and oncologists.
  • Covering anatomical, clinical, pathological and laboratory aspects of surgical histopathology specimens, this book relates specimen dissection and its clinical context to relevant histopathology reports, and therefore a more comprehensive patient prognosis and management is possible. This book explains pathological and clinical terminology, including a glossary of clinical request form abbreviations. A standardised step-wise approach to specimen handling is illustrated with simple line diagrams and highlights essentials of the histopathology report, relating them to appropriate specimen dissection. The integrated multidisciplinary team approach taken to the modern clinical management of patients is reflected by correlating patient presentation, diagnostic and staging investigations with histopathology specimens. Current WHO and TNM tumor classifications are referenced. This book will be of educative value and act as a reference tool for the medical undergraduate student, medical trainee in histopathology and the biomedical scientist, and as a useful aide memoire for the histopathology consultant.
  • Humanized mice 2008
    Springer
    Basic Concept of Development and Practical Application of Animal Models for Human Diseases / Tatsuji Nomura, N. Tamaoki, A. Takakura and H. Suemizu, p. 25-51-- Humanized SCID Mouse Models for Biomedical Research / T. Pearson, D. L. Greiner and L. D. Shultz, p. 53-76 -- NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models / M. Ito, K. Kobayashi and T. Nakahata, p. 77-86 -- Humanizing Bone Marrow in Immune-Deficient Mice / K. Ando, Y. Muguruma and T. Yahata, p. 87-94 -- The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2rγnull Mice / F. Ishikawa, Y. Saito, S. Yoshida, M. Harada and L. D. Shultz, p. 95-107 -- Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System / M. Ito, M. Shiina, Y. Saito, Y. Tokuda and Y. Kametani, et al., p. 109-124 -- Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development / N. D. Huntington and J. P. Di Santo, p. 125-131 -- Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice / S. Baenziger, P. Ziegler, L. Mazzucchelli, L. Bronz and R. F. Speck, et al., p. 133-148 -- Humanized Mice for Human Retrovirus Infection / Y. Koyanagi, Y. Tanaka, M. Ito and N. Yamamoto, p. 149-165 -- Functional and Phenotypic Characterization of the Humanized BLT Mouse Model / A. K. Wege, M. W. Melkus, P. W. Denton, J. D. Estes and J. V. Garcia, p. 167-177 -- Novel Metastasis Models of Human Cancer in NOG Mice / M. Nakamura and H. Suemizu, p. 179-196 -- In Vivo Imaging in Humanized Mice / H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura and H. Okano, et al.
  • Considerations for routine imaging -- Entering the portal: understanding the digital image recorded through a microscope -- Quantitative biological image analysis -- The open microscopy environment: a collaborative data modeling and software development project for biological image informatics -- Design and function of a light-microscopy facility -- Advanced methods and concepts -- Quantitative colocalisation imaging: concepts, measurements, and pitfalls -- Quantitative FRET microscopy of live cells -- Flourescence photobleaching and flourescence correlation spectroscopy: two complementary technologies to study molecular dynamics in living cells -- Single fluorescent molecule tracking in live cells -- From live-cell microscopy to molecular mechanisms: deciphering the functions of kinetochore proteins -- Cutting edge applications & utilities -- Towards imaging the dynamics of protein signalling -- New technologies for imaging and analysis of individual microbial cells -- Imaging parasites in vivo -- Computer-assisted systems for dynamic 3D reconstruction and motion analysis of living cells -- High-throughput/high-content automated image acquisition and analysis -- Cognition network technology: a novel multimodal image analysis technique for automatic identification and quantification of biological image contents -- High-content phenotypic cell-based assays.
  • In vitro toxicology systems 2014
    Springer Protocols
    In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
  • Inflammation protocols 2003
    Springer Protocols
  • "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • Introduction to normal values (reference ranges) -- Critical values -- Core blood analytes: alterations by diseases -- Urine -- Cardiovascular diseases -- Respiratory diseases -- Gastrointestinal diseases -- Hepatobiliary diseases and diseases of the pancreas -- Central and peripheral nervous system disorders -- Musculoskeletal and joint diseases -- Hematology -- Metabolic and hereditary disorders -- Endocrine diseases -- Genitourinary diseases -- Infectious diseases -- Autoimmune and miscellaneous diseases -- Disorders due to physical and chemical agents -- Therapeutic drug monitoring and drug effects -- Body substances.
  • This volume acquaints the non-neuropathologist with the advantages of clinical-radiologic-pathologic correlation in neuropathology specimens, particularly in the intra-operative environment. This volume covers the enormous and sometimes insurmountable artifacts involed with freezing tissue, especially central nervous system tissue and how a good cytology preparation can add to, or even supply in isolation, a diagnosis. The text presents how to perform, and stain the cytologic preparations, and how to interpret them. The advantages and disadvantages of both frozen sections and cytologic preparations of various kinds are discussed. The presentation and format is very visual with diagrams, tables (including pearls and pitfalls), and many figures (therefore easy reading).An introductory chapter presents the pros and cons of supplemental cytology, the advantages and disadvantages of frozen sections, and the artifacts in both. Also included is an argument for knowing what the scans reveal and the impact of relevant patient history. The volume uses a case-based approach to show correlation between scan, history, frozen section and cytologic preparations.With the combination of extensive correlation of scans, cytology and frozen section with differential diagnosis, and analysis of the information crucial to the neurosurgeon in a case-based approach and with a special chapter written by a neuroradiologist, this volume is unique in presentation and utility and will be of great value to the trainee in pathology (residents/fellows), and practicing pathologists who include neuropathology in their practice, but do not have formal fellowship training in neuropathology.
  • "When a patient is under anesthesia, every second counts. An intraoperative consultation provides essential information to ensure every operation has a successful conclusion. The stakes are high and the challenges are great -- no special stains, limited access for consultation with colleagues, often suboptimal slide preparation, and cases that may be out of a pathologist's normal sphere of practice. Diagnostic Pathology: Intraoperative Consultation is designed to be the best resource when pathologists need assistance. No time is wasted looking for information because each chapter is directed to a specific question posed by a surgeon, such as 'Does this patient have pancreatic cancer?', 'Is there an intrauterine pregnancy?', 'Does this patient have lung cancer?', or 'Are the margins free of carcinoma?' The clinical setting and what the surgeon needs to know -- and why -- are explained. Specimen processing (gross and microscopic), tissue selection, and reporting of results are detailed. All major entities in the differential diagnosis are described and shown in photographs. Major pitfalls are discussed and illustrated. This is the book every pathologist will want at their side the next time a page calls them to the frozen section room"--Provided by publisher.
  • This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding, and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life, and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists, and researchers with an interest in kidney diseases.
  • "Up-to-date, comprehensive, and beautifully illustrated, Laboratory Diagnosis in Neurology presents all the measuring parameters and methods relevant to the analysis of cerebrospinal fluid, serum, and tissues affected by neurologic disease and syndromes. Following an introduction to basic concepts, the book guides clinicians through the methods of CSF analysis, neurochemical examinations, clinical applications of neuroimmunology, microbiology and virology, neurogenetic tests, and evaluation of biopsies. Readers will learn about the equipment and various procedures, and how to effectively differentiate similar methods. In the final section of the book, the authors provide a systematic introduction to the pathophysiology and laboratory findings for specific clinical disorders, indications for particular test methods, and criteria for diagnostic interpretation"--Provided by publisher.
  • Laboratory primate 2005
    ScienceDirect
  • Laboratory Statistics: Handbook of Formulas and Terms presents common strategies for comparing and evaluating numerical laboratory data. In particular, the text deals with the type of data and problems that laboratory scientists and students in analytical chemistry, clinical chemistry, epidemiology, and clinical research face on a daily basis. This book takes the mystery out of statistics and provides simple, hands-on instructions in the format of everyday formulas. As far as possible, spreadsheet shortcuts and functions are included, along with many simple worked examples. This book is a must-have guide to applied statistics in the lab that will result in improved experimental design and analysis. Comprehensive coverage of simple statistical concepts familiarizes the reader with formatted statistical expressionSimple, worked examples make formulas easy to use in real lifeSpreadsheet functions demonstrate how to find immediate solutions to common problemsIn-depth indexing and frequent use of synonyms facilitate the quick location of appropriate procedures.
  • "Look no further for quick, complete answers to questions such as which laboratory tests to order or what the results might mean. Laboratory Tests And Diagnostic Procedures, 5th Edition covers more tests than any other reference of its kind, with over 900 lab tests and diagnostic procedures in all. In Part I, you'll find a unique, alphabetical list of hundreds of diseases, conditions, and symptoms, including the tests and procedures most commonly used to confirm or rule out a suspected diagnosis. Part II presents key information on virtually every laboratory and diagnostic test available. All test entries are up-to-date, concise, complete, and consistently presented, making this resource the perfect choice for students or practitioners who need fast, accurate information on diagnostic tests."--Publisher's website.
  • Introduction -- Overview of ancillary methods in lymph node FNA diagnosis -- Lymphadenopathy: anatomic and clinical clues to fine needle aspiration diagnosis -- Cytology of normal/reactive lymph nodes -- Overall assessment of the aspirate: diagnostic clues -- Overview of the algorithmic pattern-based approach to lymph node FNA -- The polymorphous lymphoid cell pattern -- The monotonous small-cell pattern -- The monotonous intermediate-sized cell pattern -- The monotonous large cell pattern -- The pleomorphic cell pattern -- Infectious and noninfectious lympadenitis -- Unusual neoplastic and nonneoplastic conditions of lymph nodes -- Pitfalls and limitations of FNA of lymph nodes.
  • 2011 ClinicalKey
    1. Anatomy, pathophysiology and basic mechanisms of disease / James M. Crawford and Alastair D. Burt -- 2. Cellular and molecular techniques / Pierre Bedossa and Valerie Paradis -- 3. Developmental abnormalities and liver disease in childhood / Bernard C. Portmann and Eve A. Roberts -- 4. Genetic and metabolic liver disease / Richard J. Thompson, Bernard C. Portmann and Eve A. Roberts -- 5. Disorders of iron overload / Alan C. Paterson and Antonello Pietrangelo -- 6. Fatty liver disease : alcoholic and non-alcoholic / Elizabeth M. Brunt, Brent A. Neuschwander-Tetri and Alastair D. Burt -- 7. Acute and chronic viral hepatitis / Neil D. Theise, Henry C. Bodenheimer Jr. and Linda D. Ferrell -- 8. Other viral and infectious diseases and HIV-related liver disease / Sebastian B. Lucas, Sherif R. Zaki and Bernard C. Portmann -- 9. Autoimmune hepatitis / M. Kay Washington and Michael P. Manns -- 10. Diseases of the bile ducts / Yasuni Nakanuma, Yoh Zen and Bernard C. Portmann -- 11. Diseases of the gallbladder / Jorge Albores-Saavedra and Arturo Angeles-Angeles --12. Vascular disorders / Ian R. Wanless and Weei-Yuarn Huang -- 13. Hepatic injury due to drugs, herbal compounds, chemicals and toxins / James H. Lewis and David E. Kleiner -- 14. Tumours and tumour-like lesions of the liver / Zachary D. Goodman, Luigi M. Terracciano and Aileen Wee -- 15. Transplantation pathology / Stefan G. Hübscher and Andrew D. Clouston -- 16. Systemic disease / Alberto Quaglia, Alastair D. Burt, Linda D. Ferrell, Bernard C. Portmann.
  • "This second edition provides guidance on all aspects of how to make and use antibodies for research, and commercial and industrial applications. All chapters are revised, updated, or expanded. New material in the book includes western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present descriptions of basic methods for making and using antibodies and describe basic laboratory techniques in detail. Each chapter includes introductory material, allowing for a better understanding of each concept. Practical examples are also included"--Provided by publisher.
  • Diagnostic testing -- Blood studies : hematology and coagulation -- Urine studies -- Stool studies -- Cerebrospinal fluid studies -- Chemistry studies -- Microbiologic studies -- Immunodiagnostic studies -- Nuclear medicine studies -- X-ray studies -- Cytologic, histologic, and genetic studies -- Endoscopic studies -- Ultrasound studies -- Pulmonary function, arterial blood gases (abgs), and electrolyte studies -- Prenatal diagnosis and tests of fetal well-being -- Special diagnostic, special specimen collection, and postmortem studies.
  • Dr. Lester's Manual of Surgical Pathology, 3rd Edition offers complete, practical guidance on the evaluation of the surgical pathology specimen, from its arrival in the department to preparation of the final report. Inside, you'll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. This thoroughly revised New Edition integrates cutting-edge procedures well as the latest staging and classification information. Coverage of the latest standards and procedures for the laboratory and handling of surgical pathology specimens are valuable assets to pathologists, pathology assistants, and anyone working in a pathology laboratory. Plus, with Expert Consult functionality, you'll have easy access to the full text online as well as all of the books illustrations and links to Medline. Features more than 150 tables that examine the interpretation of histochemical stains, immunohistochemical studies, electron microscopy findings, cytogenetic changes, and much more. Presents a user-friendly design, concise paragraphs, numbered lists, and bulleted material throughout the text that makes information easy to find. Offers detailed instructions on the dissection, description, and sampling of specimens. Includes useful guidance on operating room consultations, safety, microscope use, and error prevention. Explains the application of pathology reports to patient management. Discusses how to avoid frequent errors and pitfalls in pathology specimen processing.
  • 2005 Springer Protocols
    Basic techniques in molecular biology / Ralph Rapley -- Probe design, production, and applications / Marilena Aquino de Muro -- Restriction enzymes: tools in clinical research / Gareth J.S. Jenkins -- Southern blotting as a diagnostic method / Bronwen Harvey and Pirkko Soundy -- Western blotting as a diagnostic method / Pirkko Soundy and Bronwen Harvey -- Principles and medical applications of the polymerase chain reaction / Bimal D. M. Theophilus -- Single strand conformation polymorphism (SSCP) analysis / Igor Vorechovsky -- Denaturing gradient gel electrophoresis (DGGE) / Jeroen H. Roelfsema and Dorien J.M. Peters -- Quantitative analysis of DNA sequences by PCR and solid phase sequencing / Anu Suomalainen and Ann-Christine Syvänen -- Introduction to capillary electrophoresis of DNA: biomedical applications / Beatriz Sanchez-Vega -- Mapping techniques / Simon G. Gregory -- Dideoxyfingerprinting for mutation detection / Ioannis Bossis, Antonios Voutetakis, and Constantine A. Stratakis -- Conformation sensitive gel electrophoresis / Marian Hill -- Amplification refractory mutation system and molecular diagnostics / Richard Kitching and Arun Seth -- Ligase chain reaction / Carla Osiowy -- Chemical cleavage of mismatch: theory and clinical applications / Neil V. Whittock and Louise Izatt -- The protein truncation test / Johan T. den Dunnen -- Linkage, allele sharing, and association / Mara Giordano -- Single nucleotide polymorphisms: technology and applications / Cyril Mamotte, Frank Christiansen, and Lyle J. Palmer -- cDNA microarrays / Philip G. Febbo -- Nucleic acid sequence-based amplification / Katherine Loens, D. Ursi, H. Goosens, and M. Ieven -- The oligonucleotide ligation assay / Faye A. Eggerding -- Quantitative taqman real-time PCR: diagnostic and scientific applications / Jörg Dötsch, Ellen Schoof, and Wolfgang Rascher -- Use of denaturing high-performance liquid chromatography in molecular medicine / Elizabeth L. Rugg and Gareth J. Magee -- Quantitative PCR / David Sugden -- Liquid chromatography-mass spectrometry of nucleic acids / Herbert Oberacher and Walther Parson -- Comparative genomic hybridization in clinical and medical research / Peng-Hui Wang, Yann-Jang Chen, and Chi-Hung Lin -- Bioinformatics tools for gene and protein sequence analysis / Bernd H.A. Rehm and Frank Reinecke -- In situ hybridization / Amanda D. Watters -- Enzyme-linked immunosorbent assay / William J. Jordan -- Protein therapeutics: mouse, humanized, and human antibodies / Benny K.C. Lo -- Karyotyping / Avery A. Sandberg, John F. Stone, and Zhong Chen -- Microsatellite analysis / Rachel E. Ibbotson and Anton E. Parker -- Analysis of chromosomal translocations / Andreas Hochhaus -- Differential display: theory and applications / Irina Gromova, Pavel Gromov, and Julio E. Celis -- Techniques for gene expression profiling / Mark P. Richards -- Capillary electrophoresis in clinical analysis / Margaret A. Jenkins and Sujiva Ratnaike -- Flow cytometry in the biomedical arena / James L. Weaver and Maryalice Stetler-Stevenson -- Immunocytochemistry / Patricia A. Fetsch -- Ribotyping in clinical microbiology / Patricia Severino and Sylvain Brisse -- Diagnostic applications of protein microarrays / Samir Hanash -- The human genome project / Rahul Chodhari and Eddie Chung -- Prenatal diagnosis of inborn errors of metabolism / Guy T.N. Besley -- Gene therapy: methods and application / Stella B. Somiari.
  • Microchip methods in diagnostics 2009
    Springer Protocols
    DNA microarrays: an introduction to the technology / Ursula Bilitewski -- Discussion of the applicability of microarrays: profiling of leukemias / Torsten Haferlach ... [et al.] -- Expression profiling using Affymetrix GeneChip microarrays / Herbert Auer, David L. Newsom, and Karl Kornacker -- Genotyping of mutation in the beta-globin gene using DNA microarrays / Martin Dufva and Lena Poulsen -- Antibody-based microarrays / Christer Wingren and Carl A.K. Borrebaeck -- Application of protein ArrayTubes to bacteria, toxin, and biological warfare agent detection / Ralf Ehricht ... [et al.] -- Detection of known allergen-specific IgE antibodies by immunological methods / Barbara I. Fall and Reinhard NieSner -- Peptide microarrays for serum antibody diagnostics / Heiko Andresen and Frank F. Bier -- Microchips for cell-based assays / Martin Dufva -- Bio-cell chip fabrication and applications / Honggu Chun, Dong Soon Lee, and Hee Chan Kim -- Microchip capillary electrophoresis / Elaine T.T. Tay ... [et al.] -- Detection of enteropathogenic Escherichia Coli by microship capillary electrophoresis / Wai S. Law, Sam F.Y. Li, and Larry J. Kricka.
  • Part 1. Current Molecular Laboratory Methods -- Specimen Collection, Handling, and Processing / Lindsy Hengesbach and John A. Gerlach -- DNA/RNA Isolation and Quantitation / Jing Wang -- Test Validation / Cindy McCloskey and S. Terence Dunn -- In Vitro Amplification Methods in Molecular Diagnostics / C. Alexander Valencia and Bradford Coffee -- Whole Genome Sequencing in the Clinical Laboratory / Tina Hambuch, Brad Sickler, Arnold Liao, Suneer Jain and Philip D. Cotter -- Estimation of Exon Dosage Using Real-Time Quantitative Polymerase Chain Reaction / Applications to Factor VIII Gene in Hemophilia A and Endoglin/ACVRL1 Genes in Hereditary Hemorrhagic Telangiectasia / Juliana Purrazzella and Arupa Ganguly -- Reporting Clinical Molecular Genetic Laboratory Results / Victor Wei Zhang and Lora J. H. Bean -- Part 2. Clinical Molecular Infectious Disease Testing -- HIV-1 Genotyping and Virtual Phenotyping / Fangling Xu and Jianli Dong -- COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test, Version 2.0 / Tavat A. Buraruk and Charles E. Stager -- Hepatitis C Virus (HCV) Genotype Assay (LiPA) / Charles E. Stager and Tavat A. Buraruk -- COBAS® AmpliPrep/COBAS® TaqMan® HCV Test / Charles E. Stager and Tavat A. Buraruk -- Epstein-Barr Virus and Cytomegalovirus Viral Load Monitoring by Quantitative Real-Time Polymerase Chain Reaction / Su S. Chen, Seema Hai, Margaret L. Gulley and Rajyalakshmi Luthra -- Quantification of BK Viral Load / Hai Wu and Jianli Dong -- Molecular Diagnosis and Epidemiology of Rabies / Rodney E. Rohde and Bonny C. Mayes -- Pyrosequencing for Bacterial Identification / Laura Millecker and Ruth Ann Luna -- Other Pathogens of Significant Public Health Concern / Chris L. McGowin, Rodney E. Rohde and Greg C. Whitlock -- Part 3. Clinical Molecular Oncology Testing -- Gene Rearrangements Testing / Siby Sebastian, Juan Du and Rizwan Naeem -- Mutation Analysis in Cancer / Keyur Pravinchandra Patel, John Galbincea and Rajyalakshmi Luthra -- Minimal Residual Disease / Wesley O. Greaves and Rajyalakshmi Luthra -- Pyrosequencing in Cancer / Shalini Verma, Bedia A. Barkoh and Rajyalakshmi Luthra -- Clinical Applications of Microarrays in Cancer / Marilyn M. Li, Ankita Patel and Xiaofeng Hu -- Basic Theories and Clinical Applications of Molecular Flow Cytometry / Hua-Kang Wu, Hongli Chen and Peter C. Hu -- Part 4. Clinical Molecular Pre/Postnatal Testing -- Molecular Prenatal Diagnostic Testing / Joanna Wiszniewska and Christine M. Eng -- PCR Based Diagnosis of Fragile X Syndrome / Daniel J. Dykas and Allen E. Bale -- Part 5. Human Identity Testing -- Microsatellite Testing Short Tandem Repeat Profile Generation / Robin DeVille Guidry and Laura Gahn -- Parentage / Laura Gahn and Robin DeVille Guidry -- Part 6. Clinical Molecular Training -- Diagnostic Molecular Training / Peter C. Hu, Patrick Alan Lennon and Madhuri R. Hegde -- Molecular Diagnostics Point of Care Testing Training / Chang W. Lee and Peter C. Hu.
  • Modern surgical pathology. 2nd ed. v.1-2, 2009
    ClinicalKey
    Part I: The Surgical Pathology Laboratory -- 1. Gross Room and Specimen Handling -- Lucien E. Nochomovitz -- 2. Intraoperative Consultations in Surgical Pathology -- Mahendra Ranchod -- 3. The Surgical Pathology Report -- Debra Hawes, Richard J. Cote, Noel Weidner -- 4. Anatomic Pathology Laboratory Information Systems -- Anil V. Parwani, Eric Schubert, William Gross, John Gilbertson, Michael J. Becich -- 5. Immunohistochemistry -- Debra Hawes, Shan-Rong Shi, David J. Dabbs, Clive R. Taylor, Richard J. Cote -- 6. Role of Electron Microscopy in Modern Diagnostic Surgical Pathology -- Robert A. Erlandson -- 7. Molecular Biology -- Sharon P. Wilczynski -- 8. The Essential Quality Improvement and Educational Programs in Surgical Pathology -- Robert R. Rickert -- 9. Medicolegal Issues in Surgical Pathology -- David B. Troxel -- Part 2: Head and Neck -- 10. Nasal Cavity, Paranasal Sinuses, and Nasopharynx -- Bruce M. Wenig, Mary Richardson -- 11. Larynx -- Lester D.R. Thompson -- 12. Salivary Glands -- Gary L. Ellis, Paul L. Auclair -- 13. Ear and Temporal Bone -- Bruce M. Wenig -- 14. Oral Cavity and Jaws -- Noel Weidner, Kurt Matthews, Joseph A. Regezi -- Part 3: Thoracic System -- 15. Lung -- Saul Suster, Cesar A. Moran -- 16. Serosal Membranes -- Lawrence M. Weiss -- 17. Mediastinum -- Saul Suster, Cesar A. Moran -- 18. Heart and Blood Vessels -- Allen Burke, Renu Virmani -- Part 4: Breast -- 19. Breast -- Noel Weidner -- Part 5: Gastrointestinal Tract -- 20. Esophagus -- Christopher A. Moskaluk -- 21. Stomach -- David Lewin, Klaus J. Lewin (deceased) -- 22. Small Intestine -- David Lewin, Klaus J. Lewin (deceased) -- 23. Large Intestine (Colon) -- Robert E. Petras, Wendy Frankel -- 24. Appendix -- Norman J. Carr, Leslie H. Sobin -- 25. Anus -- David A. Owen -- 26. Pancreas -- Ralph H. Hruban, Noriyoshi Fukushima, Robb E. Wilentz -- 27. Liver -- M. Kay Washington -- 28. Gallbladder and Extrahepatic Bile Ducts -- M. Kay Washington -- Part 6: Urinary Tract and Male Genital System -- 29. Non-Neoplastic Kidney -- Sharda G. Sabnis, Michael N. Koss, W.B. Ross, Zdena Pavlova -- 30. Renal Neoplasia -- John N. Eble, Liang Cheng -- 31. Bladder and Urethra -- Richard J. Cote, Anirban P. Mitra, Mahul B. Amin -- 32. Prostate -- David G. Bostwick, Isabelle Meiers -- 33. Penis and Scrotum -- Pheroze Tamboli, Antonio L. Cubilla, Mahul B. Amin -- 34. Testis and Paratestis Including Spermatic Cord -- Satish K. Tickoo, Pheroze Tamboli, Nancy E. Warner, Mahul B. Amin -- Part 7: Female Reproductive System -- 35. Vulva and Vagina -- Juan C. Felix, R. Tucker Burks, Charles A. Amezcua -- 36. Cervix -- Juan C. Felix, Thomas C. Wright, Jr., Charles A. Amezcua -- 37. Uterus -- Noel Weidner, Michael Peterson -- 38. Fallopian Tubes and Broad Ligament -- Noel Weidner, Michael Peterson -- 39. Ovaries -- Noel Weidner, Michael Peterson -- 40. Gestational Pathology -- Cynthia G. Kaplan -- Part 8: Hematolymphoid System -- 41. Lymph Nodes -- Karen L. Chang, Daniel A. Arber, Lawrence M. Weiss -- 42. Spleen -- Daniel A. Arber -- 43. Bone Marrow -- Daniel A. Arber -- Part 9: Endocrine System -- 44. Thyroid and Parathyroid -- Loretta L.Y. Tse, John K.C. Chan -- 45. Adrenal Gland -- Lawrence M. Weiss, Sean K. Lau -- Part 10: Soft Tissue and Skeletal System -- 46. Soft Tissues -- Lawrence M. Weiss -- 47. Joint and Bone Pathology -- Noel Weidner, Grace Y. Lin, Michael Kyriakos -- Part 11: Skin -- 48. Inflammatory Skin Conditions -- Još Antonio Plaza, Victor G. Prieto -- 49. Tumors of the Skin -- Saul Suster, Tai-Yuen Wong, Martin C. Mihm, Jr. -- Part 12: Nervous System -- 50. Pituitary -- David R. Hinton, Sylvia L. Asa -- 51. Central Nervous System Tumors -- Mahlon D. Johnson, James B. Atkinson -- 52. The Molecular and Genetic Basis of Neurodegenerative Diseases -- Thomas A. Tousseyn, Jeffrey P. Simko, David A. Gaskin, Stephen J. DeArmond -- 53. Muscle and Nerve Biopsy -- James B. Atkinson, Mahlon D. Johnson, Thomas W. Bouldin, William O. Whetsell, Jr. -- 54. Eye and Ocular Adnexa -- Somsiri Sukavatcharin, Narsing A. Rao.
  • The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
  • Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
  • "This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers -- clinicians, pathologists, laboratorians, and other inquisitive minds -- independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing "excise and pray" approaches with personalized medicine."--Publisher's website.
  • Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
  • Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
  • Basics of molecular biology -- Molecular pathology methods -- Genetic counseling -- Pedigree analysis and risk assessment -- Bayesian analysis -- Developmental disabilities -- Neuromuscular diseases -- Molecular genetic testing for metabolic disorders -- Fibroblast growth factor receptor-related skeletal disorders -- Cystic fibrosis -- Deafness -- Coagulation disorders -- Hematologic disorders : hemochromatosis, hemoglobinopathies, and Rh incompatibility -- Cardiovascular disease -- Neurodegenerative disorders -- Skin and connective tissue disorders -- Inherited breast cancer -- Familial adenomatous polyposis and Turcot and Peutz-Jeghers syndromes -- Hereditary nonpolyposis colorectal cancer -- Multiple endocrine neoplasia syndromes -- The neurofibromatoses -- TP53 mutation and Li-Fraumeni syndrome -- von Hippel-Lindau disease -- Breast cancer -- Urothelial carcinoma -- Sarcomas -- Gliomas -- Molecular detection of occult tumor cells -- Microarray studies (Beyond histology) -- Acute myeloid leukemia -- Acute lymphoblastic leukemia -- B-cell lymphomas -- T-cell lymphomas -- Lymphoproliferations of immunodeficiency -- Myeloproliferative disorders and myelodysplastic syndromes -- Human immunodeficiency virus type 1 -- Hepatitis B and C viruses -- Viral infections in transplant patients -- Viral infections of the central nervous system -- Sexually transmitted diseases -- Respiratory pathogens -- Bacterial pathogens -- Mycobacterial infections -- Forensic DNA typing -- Parentage and relationship testing -- Assessment of chimerism in the setting of allogenic hematopoietic cell transplantation -- Specimen identification through DNA analysis -- Molecular HLA typing -- Molecular pathology laboratory management -- From research to clinical practice.
  • Molecular oncogenesis -- Systematic autoimmune diseases -- MicroRNAs in endocrine diseases -- Clinical detection and treatment of thyroid diseases -- Autoimmune thyroid diseases -- Benign nodular thyroid disease -- Fine needle aspiration: present and future -- Well-differentiated papillary thyroid carcinoma -- Well-differentiated thyroid follicular carcinoma -- Poorly differentiated and undifferentiated thyroid carcinomas -- Medullary thyroid carcinoma -- Unusual thyroid tumors -- Hematopoietic tumors of the thyroid -- Clinical detection and treatment of parathyroid diseases -- Nonneoplastic parathyroid diseases -- Neoplastic parathyroid diseases -- Clinical detection and treatment of benign and malignant pituitary diseases -- Nonneoplastic and neoplastic pituitary diseases -- Clinical detection and treatment of adrenal disease -- Benign and malignant pheochromocytomas and paragangliomas -- Benign and malignant diseases of the adrenal cortex -- Clinical detection and treatment of pancreatic neuroendocrine tumors -- Pancreatic endocrine neoplasms -- Gastrointestinal neuroendocrine tumors -- Head and neck neuroendocrine tumors -- Merkel cell carcinoma -- Neuroendocrine lung tumors.
  • Section I. Molecular Pathology of Hematolymphoid Neoplasms: General Principles -- Molecular Oncogenesis / Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, and Falko Fend -- Genetic Predispositions for Hematologic and Lymphoid Disorders / Frederick G. Behm -- Prognostic Markers / David Bahler -- Cancer Stem Cells: Potential Targets for Molecular Medicine / Isabel G. Newton and Catriona H.M. Jamieson -- Gene Therapy for Leukemia and Lymphoma / Xiaopei Huang and Yiping Yang -- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression) / Richard J.Q. McNally -- Viral Oncogenesis / Alexander A. Benders and Margaret L. Gulley -- Section II. Specific Techniques and Their Applications in Molecular Hematopathology -- Techniques to Determine Clonality in Hematolymphoid Malignancies / Daniel E. Sabath -- Techniques to Detect Defining Chromosomal Translocations/Abnormalities / Jennifer J.D. Morrissette, Karen Weck, and Cherie H. Dunphy -- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease / Marie E. Beckner and Jeffrey A. Kant -- Detection of Resistance to Therapy in Hematolymphoid Neoplasms / Karen Weck -- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting / Jessica K. Booker -- Gene Expression Profiling / Cherie H. Dunphy -- Proteomics of Human Malignant Lymphoma / Megan S. Lim, Rodney R. Miles, and Kojo S.J. Elenitoba-Johnson -- Mouse Models of Hematolymphoid Malignancies / Krista M.D. La Perle and Suzana S. Couto -- Section III. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes -- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Patricia Aoun -- Marginal Zone B-Cell Lymphoma / Lynne V. Abruzzo and Rachel L. Sargent -- Lymphoplasmacytic Lymphoma / Pei Lin -- Molecular Pathology of Plasma Cell Neoplasms / James R. Cook -- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma / W. Richard Burack -- Mantle Cell Lymphoma / Kai Fu and Qinglong Hu -- Diffuse Large B-Cell Lymphomas / Cherie H. Dunphy -- The Molecular Pathology of Burkitt Lymphoma / Claudio Mosse and Karen Weck -- Precursor B-Cell Acute Lymphoblastic Leukemia / Julie M. Gastier-Foster -- Molecular Genetics of Mature T/NK Neoplasms / John P. Greer, Utpal P. Davé, Nishitha Reddy, Christine M. Lovly, and Claudio A. Mosse -- Precursor T-Cell Neoplasms / Kim De Keersmaecker and Adolfo Ferrando -- Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma / Michele Roullet and Adam Bagg -- Posttransplant Lymphoproliferative Disorder / Margaret L. Gulley -- AIDS-Related Lymphomas / Amy Chadburn and Ethel Cesarman -- Chronic Myelogenous Leukemia / Dan Jones -- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms / Mike Perez and Chung-Che (Jeff) Chang -- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid, and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis / Robert P. Hasserjian -- Molecular Pathogenesis of Myelodysplastic Syndromes / Jesalyn J. Taylor and Chung-Che "Jeff" Chang -- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemias with Normal Cytogenetics / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia / Sergej N. Konoplev and Carlos E. Bueso-Ramos -- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders / Murat O. Arcasoy and Patrick G. Gallagher -- White Blood Cell and Immunodeficiency Disorders / John F. Bastian and Michelle Hernandez -- Molecular Basis of Disorders of Hemostasis and Thrombosis / Alice Ma -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Castleman's Disease / Richard Flavin, Cara M. Martin, Orla Sheils, and John James O'Leary -- Molecular Pathology of Histiocytic Disorders / Mihaela Onciu -- Reactive Lymphadenopathies: Molecular Analysis / Dennis P. O'Malley -- Molecular Pathology of Infectious Lymphadenitides / Kristin Fiebelkorn -- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders / Kareem N. Washington, John F. Tisdale, and Matthew M. Hsieh.
  • Pituitary tumor classification : functionality, invasiveness, and aggressiveness -- Immunohistochemistry and electron microscopy as evaluation criteria in tumor classification in the deciphering of pituitary adenomas -- Proliferation -- Angiogenesis -- Apoptosis -- Signal transduction -- Stem cell markers in pituitary adenomas -- MicroRNAs -- New generic tools for diagnosis: genomics and proteomics -- Therapeutic approaches: drug, surgical, and radiotherapy.
  • Molecular Pathology of Colorectal Cancer / Fred T. Bosman -- Molecular Pathology of Pancreatic Cancer / Laura D. Wood, N. Volkan Adsay and Ralph H. Hruban -- Molecular Pathology of Liver Tumors / Thomas Longerich, Kai Breuhahn and Peter Schirmacher -- Molecular Pathology of Gallbladder Cancer / Juan Carlos Roa and N. Volkan Adsay -- Molecular Pathology of Lung Cancers / Lynette M. Sholl and Neal I. Lindeman -- Molecular Pathology of Breast Cancer / Alejandro Ariel Gru and Donald Craig Allred -- Molecular Pathology of Ovarian Cancer / Kruti P. Maniar, Ie-Ming Shih and Robert J. Kurman -- Molecular Pathology of Endometrial Cancer / Xavier Matias-Guiu and Jaime Prat -- Molecular Pathology of Kidney Tumors / Sean R. Williamson, John N. Eble and Liang Cheng -- Molecular Pathology of Prostate Cancer / Bora Gurel, Riley E. Alexander, Liang Cheng and Angelo M. De Marzo -- Molecular Pathology of Urinary Bladder Cancer / George J. Netto and Liang Cheng -- Molecular Pathology of Testicular Cancer / Katharina Biermann and Leendert H. J. Looijenga -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer / Andrea Saggini and Boris Bastian -- Molecular Pathology of Head and Neck Cancer / Audrey P. Calzada, Maie A. St. John, Elliot Abemayor and David T. W. Wong -- Molecular Pathology of Soft Tissue and Bone Tumors / Neal I. Lindeman and Paola Dal Cin -- Molecular Pathology of the Central Nervous System / Brent T. Harris and Eyas M. Hattab -- Molecular Pathology of Endocrine Cancer / Ricardo V. Lloyd, Long Jin, Darya Buehler, Heather Hardin and Weihua Shan.
  • Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.
  • Provides clear representations of common human diseases and concentrates on pathologic anatomy. Each chapter relates the anatomical changes to the functional and clinical manifestations of over 150 diseases and their underlying causes and mechanisms.
  • As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
  • Neuropathology 2014
    ClinicalKey
    Cerebral Edema -- Hydrocephalus -- Herniations -- Malformations -- Acquired Developmental Defects -- Cerebral Ischemia and Hypertensive Changes --Intracranial Aneurysms -- Vascular Malformations -- Vasculitis -- Inherited Cerebrovascular Diseases -- Closed Versus Open (Penetrating) Head Trauma -- Traumatic Intracranial Hemorrhage -- Diffuse Gliomas : Astrocytic -- Diffuse Gliomas : Oligodendroglial -- Other Astrocytic Tumors -- Ependymomas and Subependymoma -- Tumors with Ependymal-Like Features Choroid Plexus Tumors -- Neuronal and Glioneuronal Tumors -- Embryonal (Primitive) Neuroepithelial Tumors i. Meningiomas (Tumors of the Meninges) -- Nerve Sheath Tumors -- Primary CNS Lymphoma (Pcnsl) -- Pineal Parenchymal Tumors -- Germ Cell Tumors of the Central Nervous System Hemangioblastoma -- Sellar and Suprasellar Tumors -- Primary Melanocytic Tumors of the Central Nervous System -- Central Nervous System Cysts --. Metastatic Brain Tumors -- Tumors of the Skull Base -- Bacterial Infect ions -- Mycoses -- Parasitic Infections -- Viral Infections -- Neuropathology of AIDS Prion Diseases -- Alzheimer's Disease -- Frontotemporal Lobar Degenerations and Related Tauopathies -- Frontotemporal Lobar Degenerations with Ubiquitin-Inclusions (FTLD-U and FTLD-MND) (TDP-43) -- Parkinson's Disease and Related Alpha-Synucleinopathies -- Amyotrophic Lateral Sclerosis (ALS) Triple-Repeat Inherited Neurodegenerations -- Neuroaxonal Dystrophies -- Vascular Dementia and Binswanger Disease -- Multiple Sclerosis -- Acute Disseminated Encephalomyelitis -- Acute Hemorrhagic Leukoencephalitis (Hurst Disease) -- Tumefactive Demyelinating Lesions (TDL) -- Toxic Injury -- Nutritional Diseases -- Metabolic Diseases -- Peripheral Nerve Disease -- Skeletal Muscle Diseases.
  • This book provides the reader with an up-to-date, practical and succinct overview of basic neuropathology. It does not replace large reference textbooks in neuropathology but emphasizes key concepts and basic principles including recent advances, genetics and classification, and discusses important aspects of specific neuropathological disorders. It also gives practical hints on aspects of neuropathology, including how to best use the neuropathology service and interpret the results of pathological tests. The reader will gain a sufficiently broad basic knowledge of neuropathology which will be of use in their future clinical careers.Neuropathology Simplified is aimed at trainees and residents in neurology, neurosurgery and psychiatry around the world. It may also be of use to basic scientists involved in neuroscience research and also to general histopathology trainees and residents.
  • Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct.
  • 1. Getting the best answer: specimen handling and a quick review of the workings of the pathology laboratory -- 2. Normal histology of the female genital tract -- 3. Diseases of the vulva and anal neoplasia -- 4. Diseases of the vagina and urethra -- 5. Diseases of the cervix -- 6. Diseases of the endometrium -- 7. Diseases of the myometrium -- 8. Diseases of the fallopian tube -- 9. Diseaes of the ovary -- 10. Diseases of the broad ligaments and peritoneum -- 11. Pathology of the female genital tract related to pregnancy -- 12. Pathology of the placenta -- 13. Gestational trophoblastic neoplasia -- 14. Gynecologic cytology -- Index.
  • Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis, and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine, and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology, and pharmacy.
  • 2012 ClinicalKey
    Chapter 1 Introduction -- Chapter 2 The techniques of FNA cytology -- Chapter 3 Imaging methods for guidance of aspiration cytology -- Chapter 4 Head and neck; salivary glands -- Chapter 5 Lymph nodes -- Chapter 6 The thyroid gland -- Chapter 7 Breast -- Chapter 8 Lung, chest wall and pleura -- Chapter 9 Mediastinum -- Chapter 10 Liver and spleen -- Chapter 11 Pancreas, biliary tract and intra-abdominal organs -- Chapter 12 Kidney, adrenal and retroperitoneum -- Chapter 13 Male and female genital organs -- Chapter 14 Skin and subcutis -- Chapter 15 Soft tissues -- Chapter 16 Bone and cartilage -- Chapter 17 Paediatric tumors -- Chapter 18 Infectious Diseases.
  • Orthopaedic Pathology, 5th Edition, by Peter G. Bullough, MB, ChB, presents a unique, lavishly illustrated account of the pathology of arthritic disorders, metabolic disturbances, and soft tissue and bone tumors. Nearly 2,000 high-quality pathologic slides, diagnostic images, and gross specimens, side-by-side, depict the appearance of a wide range of conditions and correlate orthopaedic pathology to clinical practice for greater diagnostic accuracy. Expert Consult functionality, new to this edition, offers convenient access to the complete contents of the book online. It's the ideal resource for the orthopaedic surgeon and radiologist as well as the trainee and practicing pathologist. Provides extensive coverage of arthritic disorders, metabolic disturbances, soft tissue tumors, bone tumors, and rare disorders, not just tumors, which most books emphasize, for guidance on the most commonly seen conditions. Uses nearly 2000 high-quality illustrations, including pathology, histology, radiologic imaging, and schematic line diagrams, that present a clear visual correlation between pathology and clinical images to aid in diagnosis. Includes a chapter on imaging techniques, interpretation, and strategies that provides a foundation of knowledge in radiology. Features brief text, including bulleted lists of key points and information, that makes reference quick and learning easy.
  • Oxygen biology and hypoxia 2007
    ScienceDirect
  • Introduction to Pancreatic Cytopathology -- Pancreatic Cytopathology: A Pragmatic Approach -- Pancreatic Ductal Adenocarcinoma and Its Variants -- Ancillary Testing for the Diagnosis of Pancreatic Ductal Adenocarcinoma -- Acinar Cell Carcinoma -- Pancreatoblastoma -- Solid-Pseudopapillary Neoplasm -- Pancreatic Endocrine Tumors -- Cystic Muscus-Producing Neoplasia: Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms -- Other Cystic Lesions of the Pancreas -- Inflammatory Disease of the Pancreas -- Secondary Malignancies of the Pancreas.
  • The Impact of Foreign DNA Integration on Tumor Biology and Evolution via Epigenetic Alterations / Walter Doerfler -- The Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome / Sole Gatto, Maurizio D'Esposito and Maria R. Matarazzo -- Dysfunction of the Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome / Gaston Calfa, Alan K. Percy and Lucas Pozzo-Miller -- Epigenetic Alterations in Glioblastoma Multiforme / John K. Wiencke -- Aberrant Epigenetic Regulation in Breast Cancer / Amanda Ewart Toland -- The Impact of Epigenetic Alterations on Diagnosis, Prediction, and Therapy of Prostate Cancer / Christian Arsov, Wolfgang Goering and Wolfgang A. Schulz -- Epigenetic Reprogramming in Lung Carcinomas / András Kádár and Tibor A. Rauch -- Epigenetic Changes in Virus-Associated Neoplasms / Hans Helmut Niller, Ferenc Banati, Eva Ay and Janos Minarovits -- Genetic and Epigenetic Determinants of Aggression / Barbara Klausz, József Haller, Áron Tulogdi and Dóra Zelena -- Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder / Dóra Zelena -- Disruption of Epigenetic Mechanisms in Autoimmune Syndromes / Lorenzo de la Rica and Esteban Ballestar -- Imprinting Disorders / Thomas Eggermann -- Epigenetics and Atherosclerosis / Einari Aavik, Mikko P. Turunen and Seppo Ylä-Herttuala -- Microbe-Induced Epigenetic Alterations / Hans Helmut Niller, Ferenc Banati, Eva Ay and Janos Minarovits.
  • This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen. This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information. One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery.
  • The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, and analysis of tissue mineral fiber content. In addition, the medicolegal issues relating to asbestos-associated diseases are analyzed from the point of view of both the plaintiff and the defendant. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.
  • Part I: Introductory Chapters -- Chapter 1. Gross Prosection of Melanocytic Lesions -- Chapter 2. Histopathologic Staging and Reporting of Melanocytic Lesions -- Chapter 3. Clinicopathologic Correlation in Melanocytic Lesions -- Chapter 4. Anathema or Useful? Application of Immunohistochemistry to the Diagnosis of Melanocytic Lesions -- Chapter 5. Applications of Additional Techniques to Melanocytic Pathology -- Part 2: Diagnostic Challenges -- Chapter 6. Spitz Nevus versus Spitzoid Melanoma -- Chapter 7. Halo Nevus versus Melanoma with Regression -- Chapter 8. Nevoid Malignant Melanoma versus Melanocytic Nevus -- Chapter 9. Dysplastic Nevi versus Melanoma -- Chapter 10. Blue Nevus versus Pigmented Epithelioid Melanocytoma -- Chapter 11. Recurrent Melanocytic Nevus versus Melanoma -- Chapter 12. Neurothekeoma versus Melanoma -- Chapter 13. Melanoma in situ versus Paget?s Disease -- Chapter 14. Desmoplastic Nevus versus Desmoplastic Melanoma -- Chapter 15. Cutaneous Metastatic Melanoma versus Primary Cutaneous Melanoma -- Chapter 16. Acral Nevus versus Acral Melanoma -- Chapter 17. Capsular (Nodal) Nevus versus Metastatic Melanoma -- Index.
  • Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated withthe aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.
  • Pediatric gastrointestinal and liver biopsies account for a significant portion of the specimens examined by a pathology laboratory. The increasingly widespread use of endoscopic procedures in children, the improved sophistication of medical imaging techniques, and the exciting expansion of knowledge in genetic medicine have all led to new advances and opportunities in pediatric hepatogastroenterology and pathology. Pathology of Pediatric Gastrointestinal and Liver Disease provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. With an emphasis on clinical-pathological correlation, the book includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts. Significant revision has been undertaken since the first edition, with the inclusion of many new illustrations and electron micrographs. Among the topics covered are malabsorption and motility disorders, immunodeficiencies, including HIV, developmental malformations, food allergies, cystic diseases of the liver, hepatic tumors, and esophageal and pancreatic disorders. The book is richly illustrated, with many figures in color, and the high-quality endoscopic and radiographic images permit ready correlation with the pathologic principles under discussion.
  • Pathology of the Human Placenta remains the most comprehensive and authoritative text in the field. It provides extensive information on the normal placenta, encompassing physiology, metabolism, and endocrinology, and covers placental diseases in great detail. The conditions discussed include shape aberrations, villous alterations and maldevelopment, erythroblastosis fetalis and hydrops fetalis, transplacental hemorrhage, fetal storage disorders, diverse maternal diseases, and infectious diseases. Further chapters are devoted to abortions, molar pregnancies, trophoblastic neoplasms, benign tumors, and multiple pregnancies. Legal considerations are carefully explored, and this new edition also includes a completely new chapter on artificial reproductive technology. In other respects, too, the book has been extensively revised and expanded, with wide-ranging updates that reflect the most recent progress in the field. Some 800 illustrations are included, many of them in color. The detailed index has been further improved and tables updated. Pathology of the Human Placenta will be of enormous value to pathologists and obstetrician-gynecologists alike.
  • 2011 ClinicalKey
    With an emphasis on practical diagnostic problem solving, Pathology of the Lungs 3e provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations. Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout. Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world's recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required.
  • As the second volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists, Pathology of the Ovary, Fallopian Tube and Peritoneum is one of the very few dealing wholly with this subject. Pathology of the Ovary, Fallopian Tube and Peritoneum introduces the topic with a discussion of the anatomy, development, histology and normal function of the ovary, followed by chapters on non-neoplastic disorders of the ovary; surgery and medical management of ovarian cancer; and the use of imaging, frozen sections and cytology in ovarian pathology. The book then goes on to describe specific disorders of the ovary, fallopian tube and peritoneum in detail, and finishes with a chapter on specimen cut-up. Pathology of the Ovary, Fallopian Tube and Peritoneum has been written to be useful diagnostically to general as well as specialist gynecological histopathologists and pathologists in training. Gynecologists, oncologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.
  • Pathology of the Pancreas: A Practical Approach covers all the diagnostic entities in adult pancreatic pathology, providing extensive illustrations and tables to assist the pathologist at the time of diagnostic reporting of histological and cytological specimens. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognize and avoid them. Pathology of the Pancreas: A Practical Approach enables the pathologist to recognize the various pathological entities and provide the key information in their pathology reports, which is necessary for the individual patient's further management. It is based on the most recent diagnostic algorithms, international consensus guidelines, and systems for disease classification, staging and grading. Clinical information is also included, where it is important for the multidisciplinary team management discussion. Pathology of the Pancreas: A Practical Approach is a bench book for everyday use beside the microscope and provides the diagnostic pathologist with a comprehensive, well-illustrated and extensively cross-referenced approach to pancreatic pathology.

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