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OncologyAccess restricted to Stanford unless otherwise noted

  • Introduction /M. Alma Rodriguez --History of MD Anderson's tumor registry /Sarah H. Taylor --Statistical methods /Geoffrey G. Giacco, Sarah H. Taylor and Kenneth R. Hess --Breast cancer /Aman U. Buzdar ... [et al.] --Prostate cancer /Deborah A. Kuban ... [et al.] --Non-small cell lung cancer /Ritsuko Komaki, Anne S. Tsao, and Reza J. Mehran --Small cell lung cancer /Frank V. Fossella --Colon cancer /Cathy Eng, Patrick Lynch, and John Skibber --Ovarian cancer /Robert L. Coleman and David M. Gershenson --Cervical cancer /Patricia J. Eifel and Charles Levenback --Endometrial cancer /Thomas Burke ... [et al.] --Pancreatic cancer (exocrine) /Jason Fleming ... [et al.] --Kidney cancer /Scott E. Delacroix Jr. ... [et al.] --Bladder cancer /Robert S. Svatek ... [et al.] --Cutaneous melanoma /Jeffrey E. Gershenwald, Geoffrey G. Giacco, and Jeffrey E. Lee --Liver cancer /Evan S. Glazer and Steven A. Curley --Esophageal cancer /Linus Ho ... [et al.] --Gastric cancer /Alexandria T. Phan and Paul F. Mansfield --Acute myeloid leukemia /Emil J. Freireich --Chronic lymphocytic leukemia/small lymphocytic lymphoma /Apostolia-Maria Tsimberidou and Michael J. Keating --Hodgkin lymphoma /Michelle Fanale ... [et al.] --Non-hodgkin indolent B-cell lymphoma /Sattva S. Neelapu --Non-hodgkin aggressive B-cell lymphoma /M. Alma Rodriguez --Multiple myeloma /Donna Weber and Raymond Alexanian --Head and neck cancer /Ehab Hanna ... [et al.] --Thyroid cancer /Steven I. Sherman, Nancy Perrier, and Gary L. Clayman --Soft tissue sarcomas /Vinod Ravi, Raphael Pollock, and Shreyaskumar R. Patel --Sarcomas of bone /Valerae Lewis.
  • AACR Education book HighWire, 2005-
  • Print Material
  • Part I. Science of Clinical Oncology -- Section A. Biology and Cancer -- 1. Molecular Tools in Cancer Research -- 2. Intracellular Signaling -- 3. The Cellular Microenvironment and Metastases -- 4. Control of the Cell Cycle -- 5. Pathophysiology of Cancer Cell Death -- 6. Cancer Immunology -- 7. Stem Cells, Cell Differentiation, and Cancer -- 8. Vascular and Interstitial Biology of Tumors -- Section B. Genesis of Cancer -- 9. Environmental Factors -- 10. DNA Damage Response Pathways and Cancer -- 11. Viruses and Human Cancer -- 12. Genetic Factors: Hereditary Cancer Predisposition Syndromes -- 13. Genetic and Epigenetic Alterations in Cancer -- 14. Immunodeficiency and Cancer -- Section C. Diagnosing Cancer -- 15. Flow Cytometry in Oncologic Diagnosis -- 16. WHO Classification of Hematologic Malignancies -- 17. Pathology, Biomarkers, and Molecular Diagnostics -- 18. Imaging -- Section D. Preventing and Treating Cancer -- 19. Biostatistics and Bioinformatics in Clinical Trials -- 20. Structures Supporting Cancer Clinical Trials -- 21. Oncology and Health Care Policy -- 22. Discovery and Characterization of Cancer Genetic Susceptibility Alleles -- 23. Cancer Prevention, Screening, and Early Detection -- 24. Nicotine Dependence: Current Treatments and Future Directions -- 25. Surgical Interventions in Cancer -- 26. Establishing and Maintaining Vascular Access -- 27. Basics of Radiation Therapy -- 28. Therapeutic Targeting of Cancer Cells: Era of Molecularly Targeted Agents -- 29. Cancer Pharmacology -- 30. Hematopoietic Stem Cell Transplantation -- 31. Gene Therapy in Oncology -- 32. Therapeutic Antibodies and Immunologic Conjugates -- 33. Complementary and Alternative Medicine -- Part II. Problems Common to Cancer and its Therapy -- Section A. Hematologic Problems and Infections -- 34. Disorders of Blood Cell Production in Clinical Oncology -- 35. Diagnosis, Treatment, and Prevention of Cancer-Associated Venous Thromboembolism -- 36. Infection in the Patient with Cancer -- Section B. Metabolic and Paraneoplastic Syndromes -- 37. Hypercalcemia -- 38. Tumor Lysis Syndrome -- 39. Paraneoplastic Neurologic Syndromes -- 40. Cancer-Related Pain -- 41. Cancer Cachexia -- 42. Nausea and Vomiting -- 43. Oral Complications -- 44. Dermatologic Toxicities of Anticancer Therapy -- 45. Fatigue -- 46. Caring for Patients at the End of Life --Section C. Local Effects of Cancer and Its Metastasis -- 47. Acute Abdomen, Bowel/Biliary Obstruction, and Fistula -- 48. Superior Vena Cava Syndrome -- 49. Spinal Cord Compression -- 50. Brain Metastases and Neoplastic Meningitis -- 51. Bone Metastases -- 52. Lung Metastases -- 53. Liver Metastases -- 54. Malignant Effusions -- Section D. Complications of Therapy -- 55. Rehabilitation of Individuals with Cancer -- 56. Survivorship -- 57. Neurologic Complications -- 58. Pulmonary Complications of Anticancer Treatment -- 59. Cardiac Effects of Cancer Therapy -- 60. Reproductive Complications -- 61. Endocrine Complications -- 62. Second Malignant Neoplasms -- Section E. Special Populations -- 63. Cancer in the Elderly: Biology, Prevention, and Treatment -- 64. Special Issues in Pregnancy -- 65. Acquired Immunodeficiency Syndrome and Cancer -- Part III. Specific Malignancies -- 66. Cancer of the Central Nervous System -- 67. Eye, Orbit, and Adnexal Structures -- 68. Cancer of the Head and Neck -- 69. Melanoma -- 70. Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas -- 71. Cancer of the Endocrine System -- 72. Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer -- 73. Diseases of the Pleura and Mediastinum -- 74. Cancer of the Esophagus -- 75. Cancer of the Stomach and Gastroesophageal Junction -- 76. Cancer of the Small Bowel -- 77. Colorectal Cancer -- 78. Cancer of the Rectum -- 79. Cancer of the Anal Canal -- 80. Liver and Bile Duct Cancer -- 81. Carcinoma of the Pancreas -- 82. Cancer of the Kidney -- 83. Bladder Cancer -- 84. Prostate Cancer -- 85. Cancer of the Penis -- 86. Testicular Cancer -- 87. Cancers of the Cervix, Vulva, and Vagina -- 88. Uterine Cancer -- 89. Cancers Arising in the Ovary -- 90. Gestational Trophoblastic Disease -- 91. Cancer of the Breast -- 92. Sarcomas of Bone -- 93. Sarcomas of Soft Tissue -- 94. Carcinoma of Unknown Primary -- 95. Pediatric Solid Tumors -- 96. Childhood Leukemia -- 97. Childhood Lymphoma -- 98. Acute Leukemias in Adults -- 99. Myelodysplastic Syndromes -- 100. Myeloproliferative Neoplasms -- 101. Chronic Myeloid Leukemia -- 102. Chronic Lymphocytic Leukemia -- 103. Hairy Cell Leukemia -- 104. Multiple Myeloma and Related Disorders -- 105. Hodgkin Lymphoma -- 106. Non-Hodgkin Lymphoma -- 107. Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma -- 108. Adult T-Cell Leukemia-Lymphoma.
  • Approaching the treatment of AML from a biological perspective : an overview / Farhad Ravandi and Francis Giles -- Aberrant transcription factors in AML / Alan D. Friedman -- Myelodysplasia-related AML / Jane E. Parker -- Therapy-related AML / Lucy A. Godley and Michelle Le Beau -- The DNA damage response, DNA repair, and AML / David P. Steensma -- Altered apoptosis in AML : potential implications for pathogenesis and therapeutic response / Ruben A. Mesa and Scott H. Kaufmann -- Drug resistance transporters in AML / Douglas D. Ross -- Impact of cytogenetics on clinical outcome in AML / David Grimwade -- APL : a classic tale of bench to bedside / Olga Frankfurt ... [et al.] -- Emerging therapeutics for AML / Edward A. Sausville --FLT3 : a prototype receptor tyrosine kinase target in AML / Mark Levis -- Farnesyl transferase inhibitors in the therapy of AML / Jeffrey E. Lancet -- Modulating gene expression as a therapeutic approach in the treatment of AML / Tamer Fandy, Hetty Carraway, and Steven D. Gore -- Differentiation therapy in AML / Tara L. Lin and William Matsui -- Stem cell transplantation for AML / Javier Bolaños-Meade and Richard J. Jones -- Tumor vaccines in leukemia / Ivan Borrello -- Treatment, outcomes, and challenges of newly diagnosed AML in children and adolescents / Robert J. Arceci -- AML in older adults / Richard M. Stone -- Dameshek smiles : molecular clues to the chronic myeloproliferative disorders unmasked / Jason Gotlib -- New designs for clinical trials / Elihu Estey.
  • APL as a paradigm in biomedical research : a journey toward the cure / P.P. Pandolfi -- Mouse models of acute promyelocytic leukemia / S.C. Kogan -- The PLZF gene of t(11;17)-associated APL / M.J. McConnell and J.D. Licht -- SUMO, the three Rs and cancer / J.-S. Seeler ... [et al.] -- Emerging role for microRNAs in acute promyelocytic leukemia / C. Nervi ... [et al.] -- The theory of APL revisited / P.P. Scaglioni and P.P. Pandolfi -- Treatment of acute promyelocytic leukemia by retinoids / P. Fenaux, Z.Z. Wang, and L. Degos -- Arsenic trioxide and acute promyelocytic leukemia : clinical and biological / Z. Chen ... [et al.] -- Front line clinical trials and minimal residual disease monitoring in acute promyelocytic leukemia / F. Lo-Coco and E. Ammatuna -- Histone deacetylase inhibitors in APL and beyond / K. Petrie, N. Prodomou, and A. Zelent -- Monoclonal antibody therapy of APL / P.G. Maslak, J.G. Jurcic, and D.A. Scheinberg -- Targeting APL fusion proteins by peptide interference / A. Melnick -- The design of selective and non-selective combination therapy for acute promyelocytic leukemia / Y. Jing and S. Waxman.
  • Adaptive radiation therapy 2011, CRCnetBASE
  • Extracellular matrix -- Cytoskeleton -- Pseudopodia and adhesion structures -- Adhesive interactions of tissue cells with the extracellular matrix -- Cell migration -- Cell responses to chemical heterogeneity of substrata: adhesive islets or paths -- Topographic cell responses -- Intercellular adhesive interactions.
  • Preface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index.
  • Adrenocortical carcinoma 2011, Springer
    "This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care."--Publisher's website.
  • A perspective on the treatment of acute lymphoblastic leukemia in adults -- Acute lymphocytic leukemia: clinical features and making the diagnosis -- The biology of adult acute lymphoblastic leukemia -- Minimal residual disease in acute lymphoblastic leukemia -- Cytogenetics -- Acute lymphoblastic leukemia: epidemiology -- Prognostic factors in adult acute lymphoblastic leukemia (ALL) -- The generalized care of the patient with acute lymphoblastic leukemia -- Treatment of acute lymphoblastic leukemia in middle-age and older adults -- Pharmacology of acute lymphoblastic leukemia therapy -- Assessment of response to treatment -- T-cell acute lymphoblastic leukemia -- Burkitt lymphoma and leukemia -- Treatment of acute lymphoblastic leukemia in young adults -- Philadelphia chromosome positive acute lymphoblastic leukemia -- Molecular therapies -- Treatment of relapsed acute lymphoblastic leukemia -- Allogeneic stem cell transplantation for acute lymphoblastic leukemia in adults -- Hematopoietic stem cell transplantation in Philadelphia-positive acute lymphoblastic leukemia -- Special challenges: genetic polymorphisms and therapy -- Late consequences of therapy of acute lymphoblastic leukemia -- Immunotherapy for acute lymphoblastic leukemia -- Unique subtypes in acute lymphoblastic leukemia.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Advances in bone metastasis management / Piero Picci & Pietro Ruggieri -- Pathways to metastases : how do metastases develop in bone / Jeff Toreson & Robert E. Turcotte -- Metastatic spread to bone : the role of chemotherapy / Stefano Ferrari, Emanuela Palmerini, Andreas F. Mavrogenis & Pietro Ruggieri -- Bone stroma inhibition in prostate cancer / Michael A. Carducci & Daniel Keizman -- Management of bone metastases in breast cancer / Toni Ibrahim & Dino Amadori -- Radiotherapy for bone metastases / Julia Di Giovanni, Janet Nguyen, Marko Popovic & Edward Chow -- Bisphosphonates for bone metastases / Esther Chan & Urban Emmenegger -- Surgical treatment for spinal metastases / Roberto Casadei, Andreas F. Mavrogenis, Marco Manfrini & Pietro Ruggieri -- Surgical treatment for pelvic bone metastases / Andreas F Mavrogenis, Eugenio Brunocilla, Giuseppe Bianchi, Nicola Fabbri & Pietro Ruggieri -- Surgical treatment for metastatic pathological fractures / Andreas F. Mavrogenis, Roberto Casadei & Pietro Ruggieri -- Palliative treatments : selective arterial embolization for bone metastases / Giuseppe Rossi, Andreas F. Mavrogenis, Piero Picci & Pietro Ruggieri -- Palliative treatments : electrochemotherapy and thermoablation / Giuseppe Bianchi, Laura Campanacci, Eugenio Rimondi & Pietro Ruggieri -- Novel targeted therapies of bone tumors and future directions / Dominique Heymann -- Index.
  • 1. Cancer Stem Cells: A Revisitation of the "Anaplasia" Concept / Roberto Scatena -- 2. Stem Cells and Cancer Stem Cells: New Insights / Toru Kondo -- 3. Molecular Biology of Cancer Stem Cells / Oswaldo Keith Okamoto -- 4. Biomarkers of Cancer Stem Cells / Jun Dou and Ning Gu -- 5. Cancer Stem Cells and the Microenvironment / Alfonso Colombatti, Carla Danussi, Eliana Pivetta, and Paola Spessotto -- 6. Leukemia Stem Cells / Steven W. Lane and David A. Williams -- 7. Cancer Stem Cells and the Central Nervous System / Serdar Korur, Maria Maddalena Lino, and Adrian Merlo -- 8. Cancer Stem Cells and Glioblastoma Multiforme: Pathophysiological and Clinical Aspects / Akio Soeda, Mark E. Shaffrey, and Deric M. Park -- 9. Breast Cancer Stem Cells / Nuria Rodríguez Salas, Enrique González González, and Carlos Gamallo Amat -- 10. Colon Cancer Stem Cells / Ugo Testa -- 11. Liver Tumor-Initiating Cells/Cancer Stem Cells: Past Studies, Current Status, and Future Perspectives / Kwan Ho Tang, Stephanie Ma, and Xin-Yuan Guan -- 12. Pancreatic Cancer Stem Cells / Erica N. Proctor and Diane M. Simeone -- 13. Cancer Stem Cells and Renal Carcinoma / Benedetta Bussolati and Giovanni Camussi -- 14. Cancer Stem Cells: Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers / Patrizia Bottoni, Bruno Giardina, and Roberto Scatena -- 15. Cancer Stem Cells: An Innovative Therapeutic Approach / Roberto Scatena, Patrizia Bottoni, Alessandro Pontoglio, Salvatore Scarà, and Bruno Giardina -- 16. Cancer Stem Cell and ATP-Binding Cassette: Which Role in Chemoresistance? / Andrea Silvestrini, Elisabetta Meucci, Giuseppe Ettore Martorana, Bruno Giardina, and Alvaro Mordente -- 17. Stem Cells and Cancer Stem Cells: Biological and Clinical Interrelationships / Cinzia Bagalà and Carlo Barone -- 18. Immunomodulatory Functions of Cancer Stem Cells / Tobias Schatton, Jennifer Y. Lin, and Markus H. Frank.
  • Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
  • This volume is an up-to-date resource on the international state-of-the-art in the diagnosis and management of ovarian cancer. While this devastating disease has been considered mainly a disease of the Western hemisphere, the book moves beyond our conventional understanding and embraces knowledge from around the world. It focuses on recent advances in diagnosis, including genetic screening; improvements and expanded choices in management, such as gene therapy and the optimization of chemotherapeutic agents; and the latest laparoscopic and robotic surgical techniques. Further chapters address histopathologic features of this disease, and related psychosocial and quality of-life-issues. The book is aimed at the wide range of practitioners who care for patients with ovarian cancer and researchers who study the disease: general surgeons, surgical oncologists, gynecological oncologists, medical oncologists, pediatric oncologists, gynecological pathologists, gynecologists, gynecological cancer epidemiologists, gynecological onco-psychologist, genetic counselors, geneticists, and cancer research scientists.
  • Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs /Anderson T. Wang, Peter J. McHugh --DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy? /Bernard Salles D.V.M., Ph.D. --Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses /Moulay Alaoui-Jamali, Amine Saad, Gerald Batist --The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy /David Murray, Matthew Parliament --Important Roles of ERCC1 in DNA Repair and Targeted Therapy /Jennifer J. Hu, Joseph de la Garza --The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy /Andrew Y. Shuen, Jorge S. Reis-Filho --DNA-PK in CLL Chemotherapy /L. Amrein, D. Davidson, R. Aloyz, L. Panasci --Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair /Jana Krietsch, Michele Rouleau, Michel Lebel --Cellular Protection Against the Antitumor Drug Bleomycin /Dindial Ramotar Ph.D., Mustapha Aouida Ph.D. --ATR as a Therapeutic Target /Fiona K. Middleton, Nicola J. Curtin --Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy /Raina A. Tamakawa, Helen B. Fleisig --RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans /Alexander V. Mazin Ph.D., Olga M. Mazina.
  • Genome instability, checkpoints, and the cell cycle. Comparison of DNA replication in Xenopus laevis and simian virus 40 / Maren Oehlmann, Cathal Mahon, and Heinz-Peter Nasheuer. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors / P. Mathijs Voorhoeve ... [et al.] An investigation into 53BP1 complex formation / Kevin C. Roche and Noel F. Lowndes. Short abstracts--session I -- Tumor and microenvironment interactions. Tumor promotion by tumor-associated macrophages / Chiara Porta ... [et al.] The AP-2[alpha] transcription factor regulates tumor cell migration and apoptosis / Francesca Orso ... [et al.] Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation / Massimiliano Ruscica ... [et al.] Short abstracts--session II -- Animal models. The Arf tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia / Richard T. Williams and Charles J. Sherr. Short abstracts--session III -- Transcription and epigenetics. Short abstracts--session IV -- High-throughput approaches and imaging. Identification and validation of the anaplastic large cell lymphoma signature / Roberto Piva, Elisa Pellegrino, and Giorgio Inghirami. Cell-cycle inhibitor profiling by high-content analysis / Fabio Gasparri, Antonella Ciavolella, and Arturo Galvani. Short abstracts-session V -- Novel pathways and therapeutic targets. Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage / Kiyotsugu Yoshida. Short abstracts--session VI -- Poster abstracts.
  • Advances in neuroendocrine tumor management / Kjell Öberg -- Classification of digestive neuroendocrine neoplasm / Guido Rindi & Frediano Inzani -- Molecular profile and diagnosis / Christos Toumpanakis -- Surgical approach / Rossella Bettini & Massimo Falconi -- Somatostatin analogs / Wouter W. de Herder -- Combinational chemotherapy and radiotherapy / Emilio Bajetta, Emilio Bombardieri, Laura Catena, Monica Valente & Nadia Bianco -- Which therapy for which patient? / Kjell Öberg.
  • This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed nutrition and cancer from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the -omics) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions. Advances in Nutrition and Cancer will be an invaluable source of topical information for all researchers and clinicians with an interest in this field.
  • Advances in ovarian cancer management / Peter E. Schwartz -- Etiology and overview / Gang Ye, Stefanie Bernaudo & Chun Peng -- Diagnostic imaging in the management of ovarian masses / Amit Mahajan, Indukala Doddamane & Shirley McCarthy -- Initial surgical management of ovarian cancer / Jason Knight & Peter G. Rose -- Initial chemotherapy for the treatment of ovarian cancer / Katherine M. Moxley & Robert S. Mannel -- Neoadjuvant chemotherapy in the management of advanced ovarian cancer / Peter E. Schwartz -- Intraperitoneal chemotherapy : its use in epithelial ovarian cancer / Neesha Dhani & Helen Mackay -- Chemotherapeutic management of recurrent ovarian cancer / Marcia Hall -- Emerging chemotherapy agents in ovarian cancer / Daliah Tsoref & Amit M. Oza -- Surgical management of recurrent ovarian cancer / Eelco de Bree -- Angiogenesis in ovarian cancer / Vincent Castonguay & Amit M. Oza -- Antigen-specific immunotherapy for ovarian cancer / Dana M. Roque & Alessandro D. Santin -- Poly(ADP-ribose) polymerase inhibitors and epithelial ovarian cancer -- Thomas P. McNally, Gillianne G.Y. Lai & Richard T. Penson -- Emerging targeted therapies / Mirko Marabese & Massimo Broggini -- Palliative care in ovarian cancer / Cynthia O'Sullivan, Elizabeth Ercolano & Ruth McCorkle -- Guidelines in ovarian cancer / Domenica Lorusso, Antonella Pietragalla & Giovanni Scambia -- Index.
  • Advances in pancreatic cancer treatment / Helmut Friess & Norbert Hüser -- Pathophysiology of pancreatic cancer / J. Matthias Löhr, Stephan L. Haas & Rainer Heuchel -- Molecular diagnostics in pancreatic cancer / David K. Chang, Sean M. Grimmond & Andrew V. Biankin -- Surgical therapy for pancreatic cancer / Norbert Hüser, Volker Assfalg & Helmut Friess -- Multimodal treatment concepts in pancreatic cancer / Daniel Reim, Alexander Novotny & Helmut Friess -- Consensus guidelines in pancreatic cancer treatment / Wasif Saif -- Drugs in clinical trials & future directions / Zhiqiang Huang & Donald J. Buchsbaum.
  • Management of Peritoneal Surface Malignancy: A Short History / Paul H. Sugarbaker -- The Natural History of Free Cancer Cells in the Peritoneal Cavity / Yutaka Yonemura, Taiichi Kawamura, Etsurou Bandou, Gorou Tsukiyama and Yoshio Endou, et al. -- Pathological Evaluation and Implications of Serosal Involvement in Gastrointestinal Cancer / Linmarie Ludeman and Neil A. Shepherd -- Principles of Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis / Eelco de Bree and Dimitris D. Tsiftsis -- Experimental and Pharmacokinetic Studies in Intraperitoneal Chemotherapy: From Laboratory Bench to Bedside / Eelco de Bree and Dimitris D. Tsiftsis -- Technology for the Delivery of Hyperthermic Intraoperative Intraperitoneal Chemotherapy: A Survey of Techniques / Amod A. Sarnaik, Jeffrey J. Sussman, Syed A. Ahmad, Benjamin C. McIntyre and Andrew M. Lowy -- Adjuvant Intraperitoneal Chemotherapy: A Review / Paul H. Sugarbaker -- Clinical Research Methodology in Peritoneal Surface Oncology: A Difficult Challenge / François-Noël Gilly, Olivier Glehen, Annie C. Beaujard and Eddy Cotte -- Lessons Learnt from Clinical Trials in Peritoneal Surface Oncology: Colorectal Carcinomatosis / Frans A. N. Zoetmulder and Vic J. Verwaa -- Experimental Models and Questions in Basic Science Research for Pseudomyxoma Peritonei / Laura A. Lambert, Donald H. Lambert and Paul Mansfield -- Peritoneal Carcinomatosis of Colorectal Origin: Recent Advances and Future Evolution Toward a Curative Treatment / Dominique Elias and Diane Goere -- Pathologic Characterization and Differential Diagnosis of Malignant Peritoneal Mesothelioma / Nelson G. Ordóñez -- Advances in Clinical Research and Management of Diffuse Peritoneal Mesothelioma / Marcello Deraco, Dario Baratti, Nadia Zaffaroni, Antonello Domenico Cabras and Shigeki Kusamura -- Advances in the Management of Gastric Cancer with Peritoneal Dissemination / Yutaka Yonemura, Taiichi Kawamura, Etsurou Bandou, Gorou Tsukiyama and Masayuki Nemoto, et al. -- Intraperitoneal Chemotherapy in the Management of Ovarian Cancer / Maurie Markman.
  • Personalized genomic medicine: is a cancer care revolution achievable? / Dimitrios H. Roukos -- Targeting the individual cancer patient / Georgios Baltogiannis, Christos S. Katsios & Dimitrios H. Roukos -- Biomarkers-guided targeted drugs: new clinical trials design and practice necessity / Ming-Wen An, Sumithra J. Mandrekar & Daniel J. Sargent -- Personalized management for breast cancer / George C. Zografos, Dimosthenis T. Chrysikos, Paraskevi Liakou & Flora Zagouri -- Personalized management for non-small-cell lung cancer / Martin Früh, Florent Baty, Lukas Kern, Martin P. Putora & Martin Brutsche -- Personalized management for colorectal cancer / Ana Custodio & Jaime Feliu -- Successes, challenges and future directions / Stephen J. Clarke.
  • Advances in personalized therapy for lung cancer / Nagahiro Saijo -- Biomarkers in lung cancer / Tobenna Nwizu & Ravi Salgia -- EGF receptor-targeted drugs / Tetsuya Mitsudomi -- Antiangiogenic therapies for non-small-cell lung cancer / Suresh S. Ramalingam & Chandra P. Belani -- DNA-targeted drugs / Judith Meza-Junco & Michael B. Sawyer.
  • Advances in pulmonary neuroendocrine tumor management / Kjell Öberg -- Classification / Mauro Papotti -- Molecular imaging & peptide receptor radionuclide therapy / Richard P. Baum, Harshad R. Kulkarni & Dieter Hörsch -- Biotherapy : somatostatin analogs and IFN-[alpha] / Dan Granberg -- Typical and atypical bronchial carcinoid tumors / Michael Beckles, Dalvinder Mandair, Christos Toumpanakis & Martyn Caplin -- Small-cell lung cancer and large-cell neuroendocrine tumors of the lung / David Planchard & Eric Baudin -- Thymic neuroendocrine tumors / Piero Ferolla -- Algorithm for management of bronchopulmonary neuroendocrine tumors / Kjell Öberg -- Index.
  • [1.] Non-genomic Action of Steroid Hormones: More Questions than Answers / Antimo Migliaccio, Gabriella Castoria, Antonio Bilancio, Pia Giovannelli, Marzia Di Donato and Ferdinando Auricchio -- Part I. Breast Cancer -- [2.] Progesterone Signaling to Chromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling / Guillermo P. Vicent, Roser Zaurin, Cecilia Ballaré, A. Silvina Nacht, Roni H. G. Wright, Francois Le Dily, Giancarlo Castellano, Jofre Font-Mateu and Miguel Beato -- [3.] Cooperative Interactions Between c-Src, Estrogen Receptors and Receptor Tyrosine Kinases in Breast Cancer / Sarah J. Parsons, Jessica E. Pritchard, Emily M. Fox and Margaret A. Shupnik -- [4.] Cross Talk Between ER[alpha] and Src Signaling and Its Relevance to ER Status and Hormone Responsiveness / Jun Sun, Wen Zhou, Zafar Nawaz and Joyce M. Slingerland -- [5.] Post-translational Modifications of ER Alpha in Rapid Estrogen's Action / Muriel Le Romancer, Coralie Poulard, Stéphanie Sentis, and Laura Corbo -- [6.] Sex-Steroid Rapid Action and Its Role in Invasiveness and Metastasis of Breast Cancer / Marina Ines Flamini, Angel Matias Sanchez, Xiao-Dong Fu and Tommaso Simoncini -- [7.] Unraveling the Role of GPER in Breast Cancer / Rosamaria Lappano and Marcello Maggiolini -- [8.] Nongenomic Actions of Estrogens and Xenoestrogens Affecting Endocrine Cancer Cells / Cheryl S. Watson, Dragoslava Zivadinovic, Yow-Jiun Jeng, Rebecca A. Alyea, Terumi Midoro-Horiuti, Randall Goldblum and Anannya Banga -- Part II. Prostate Cancer -- [9.] Differential Functions of Stromal and Epithelial Androgen Receptor in Prostate Cancer Before and After Castration Resistant Stage / S. Lee, K.-P. Lai, S. Yeh and C. Chang -- [10.] Role of Androgens and Androgen Receptor in Prostate Cancer: Genomic and Non-Genomic Actions / Sara Marchiani, Lara Tamburrino, Monica Muratori, Lorella Bonaccorsi, Gianni Forti and Elisabetta Baldi -- [11.] Mechanisms of Signal Transduction in Prostate Cancer: The Role of PI3-Kinase Pathway in Androgen Action / Laurent Morel and Silvère Baron -- [12.] The IGF-I Axis in Prostate Cancer: The Role of Rapid Steroid Actions / Antonino Belfiore -- Androgen Receptor Pathway in Prostate Cancer: Old Target and New Drugs / Christophe Massard and Karim Fizazi -- Part III. New Tools for Steroid Receptor Analysis and Regulatory Networks -- [13.] Quantitative Visualization of Sex Steroid Receptor Functions: AR and ER[alpha] / Michael J. Bolt, Sean M. Hartig, Adam T. Szafran, Sanjay N. Mediwala, Marco Marcelli and Michael A. Mancini -- [14.] Micropatterned Surfaces as Tools for the Study of the Rapid Non-genomic Actions of Steroid Receptors / Andrew C. B. Cato, Emmanuel Oppong and Sylwia Sekula-Neuner.
  • Dawn of a new era in molecular cancer therapeutics -- Obstacles and opportunities in the clinical development of targeted therapeutics -- Tumor models for preclinical development of targeted agents -- Angiogenesis inhibitors: what is the clinical future? -- Epidermal growth factor receptor (EGFR) inhibitors in cancer therapy -- Cell survival signaling during apoptosis: implications in drug resistance and anti-cancer therapeutic development -- Targeted histone deacetylase inhibition for cancer prevention and therapy -- Inhibitors of cyclin-dependent kinase modulators for cancer therapy -- Targeting cyclooxygenase-2 for cancer prevention and treatment -- Antisense approaches in drug discovery and development -- Preclinical development of Alimta (Pemetrexed LY231514), a multitargeted antifolate.
  • Advances in the management of triple-negative breast cancer / Tiffany A. Traina & Clifford A. Hudis -- Etiology and risk factors / Laura Fejerman & Elad Ziv -- Diagnosis and pathology / Govardhanan Nagaiah & Jame Abraham -- Molecular subtypes and emerging therapeutic opportunities / Anastasia Constantinidou, Robin L. Jones & Jorge S. Reis-Filho -- Molecular profile of triple-negative breast cancer / Leonel F. Hernandez-Aya & Ana Maria Gonzalez-Angulo -- Role of metabolic rehabilitation-based approach in TNBC : biguanide metformin and more / Lev M. Berstein, Garik A. Dashyan & Vladimir F. Semiglazov -- Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer / Mark Robson -- Targeted therapies: EGFR inhibitors / Farrah M. Datko & Maura N. Dickler -- Targeted therapies : other agents in clinical trials / Brian R. Haney, Nathan M. Shumway & George E. Peoples -- Combined therapies and future directions / Anastasia Pazaiti & Ian S. Fentiman.
  • Advances in the pathogenesis and treatment of glioblastoma multiforme / Michael Prados -- Pathogenesis, molecular characteristics and prognostic factors for survival / Keith L. Ligon -- Standard treatment approaches for newly diagnosed glioblastoma / Soon-Tae Lee & Patrick Y. Wen -- Targeted therapeutic strategies for relapsed disease / John F. de Groot & Howard Colman -- Genes, viruses, toxins and vaccines as therapeutic modalities / Tal Shahar, Manish K. Aghi & Zvi Ram -- Drug delivery strategies for glioblastoma / Pin-Yuan Chen, Dali Yin, John Forsayeth & Krystof S. Bankiewicz -- Index.
  • Advances in the treatment of B-cell chronic lymphocytic leukemia / Michael J. Keating & Constantine Tam -- Chronic lymphocytic leukemia : diagnosis and clinical staging / Stephen P. Mulligan & Constantine S. Tam -- Genetics in chronic lymphocytic leukemia / Stephan Stilgenbauer & Thorsten Zenz -- To treat or not to treat / Marco Montillo, Alessandra Tedeschi & Enrica Morra -- Chronic lymphocytic leukemia chemotherapy : two decades of progress / Carol Moreno & Emili Montserrat -- Stem cell transplantation / David G. Maloney -- Treatment options for refractory chronic lymphocytic leukemia / Marina Motta & Alessandra Ferrajoli -- Prognostic markers in chronic lymphocytic leukemia / Renata Walewska & David Oscier -- Therapeutic agents in development and future direction / Sarah Mougalian & Susan O'Brien -- Index.
  • Advances in the treatment of chronic myeloid leukemia / Giuseppe Saglio & Carmen Fava -- Diagnosis and classification of the risk / Gabriele Gugliotta, Fausto Castagnetti, Francesca Palandri, Michele Baccarani & Gianantonio Rosti -- Genetics of chronic myeloid leukemia / Giovanna Rege-Cambrin, Emilia Giugliano & Patrizia Scaravaglio -- Molecular monitoring / Martin C. Müller, Christian Dietz & Benjamin Hanfstein -- Current targeted therapy with tyrosine kinase inhibitors / Massimo Breccia & Giuliana Alimena -- Stem cell transplantation and high-dose chemotherapy / Deena Iskander, Jane F. Apperley & Jirí Pavlu -- Treatment options for tyrosine kinase inhibitor-resistant chronic myeloid leukemia / Stephan Joseph Dorkhom, Hady Ghanem & Elias Jabbour -- Prognostic factors and future direction for chronic myeloid leukemia / David Marin & Antonia Rotolo -- Chronic myeloid leukemia : the possibility of a cure / Manuel Sobrinho-Simões, David M. Ross & Junia V. Melo -- Index.
  • Roles of the TNF family in tissue homeostasis and normal development -- Novel aspects of signaling activation by the TNF family: novel aspects of the functions of the TRAFs and cIAPs -- Novel aspects of signaling activation by the TNF: ubiquitin modification of signaling proteins -- Novel aspects of signaling activation by the TNF family: TNF signaling and gene regulatory networks -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: roles of the TNF family in infectious diseases -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: interrelationship of the TNF family and pattern recognition receptor signaling -- Novel aspects of immune regulation by the TNF family -- Control of lymphocyte function and repertoire by the TNF family -- Advances in applying our knowledge to therapy: mechanisms of pathological and therapeutic effects of the TNF family -- Advances in applying our knowledge to therapy: rational design of new means for therapeutic modulation of function of the TNF family -- Roles of the TNF family in neuronal development, function, and pathology -- Cell death mechanisms controlled by the TNF family -- Contributors to abstracts of talks and posters at the 12th TNF Conference -- Abstracts of talks and posters presented at the 12th TNF Conference.
  • Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
  • Ch. 1. AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression -- Ch. 2. AEG-1/MTDH/LYRIC: clinical significance -- Ch. 3. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis -- Ch. 4. Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer -- Ch. 5. Drug resistance mediated by AEG-1/MTDH/LYRIC -- Ch. 6. The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease -- Ch. 7. AEG-1/MTDH/LYRIC in liver cancer -- Index.
  • General information on cancer staging and end-results reporting -- Head and neck -- Digestive system -- Thorax -- Musculoskeletal sites -- Skin -- Breast -- Gynecologic sites -- Genitourinary sites -- Ophthalmic sites -- Central nervous system -- Lymphoid neoplasms -- Personnel and contributors.
  • Alcohol and cancer 2011, Springer
    The World Health Organization has identified chronic alcohol consumption as one of the top ten risk factors for worldwide burden of disease. The International Agency for Research on Cancer has identified alcohol as carcinogenic to humans, including cancers of the upper aerodigestive tract, colon, liver and breast. Alcohol{u2019}s actions may be direct e.g. effects on retinoic acid and one-carbon metabolism, or indirect, through metabolites such as acetaldehyde and reactive oxygen species or through various signaling pathways that influence cell cycle and apoptosis that may contribute to carcinogenesis. This volume reviews the state of the art in alcohol-related cancer research in ten chapters.
  • The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.
  • The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.
  • Overview of efficacy and limitation of standard and targeted therapy for malignant disease using lung cancer as a case study -- Overview of current TCM practice and potential impacts on conventional therapies -- Complementary and alternative medicine for cancer care in India: basic and clinical perspective -- Esophageal cancer -- Gastric cancer -- Colorectal cancer -- Liver cancer -- Pancreatic cancer -- Breast cancer -- Ovarian cancer -- Prostate cancer -- Kidney cancer -- Bladder cancer -- Brain cancer -- Complementary and alternative treatments for the management of cancer-related fatigue -- Complementary and alternative treatments for the management of cancer-related pain -- Challenges conducting clinical trials with herbal products in oncology -- Herbal product-drug interactions from a pharmacological perspective -- Patient-physician relationship: creating an optimal healing environment -- Legal issues in alternative treatment of cancer -- Intellectual property for alternative medicine -- Chemical-biology of natural products from medicinal plants for cancer therapy -- Flavonoids in cancer prevention and therapy: chemistry, pharmacology, mechanisms of action, and perspectives for cancer drug discovery -- Marine natural products and their synthetic derivatives for cancer therapy -- Natural product-like scaffolds for molecular dissection of macromolecular interactions and new therapeutic applications -- Mining natural product-derived molecules against cancer targets: the case of the androgen receptor in prostate cancer.
  • The presence of oriented features in images often conveys important information about the scene or the objects contained; the analysis of oriented patterns is an important task in the general framework of image understanding. As in many other applications of computer vision, the general framework for the understanding of oriented features in images can be divided into low- and high-level analysis. In the context of the study of oriented features, low-level analysis includes the detection of oriented features in images; a measure of the local magnitude and orientation of oriented features over the entire region of analysis in the image is called the orientation field. High-level analysis relates to the discovery of patterns in the orientation field, usually by associating the structure perceived in the orientation field with a geometrical model. This book presents an analysis of several important methods for the detection of oriented features in images, and a discussion of the phase portrait method for high-level analysis of orientation fields. In order to illustrate the concepts developed throughout the book, an application is presented of the phase portrait method to computer-aided detection of architectural distortion in mammograms.
  • Androgen action and modulation of prostate and prostate cancer growth : an historical perspective / Shutsung Liao ... [et al.] -- Clinical progression to castration-recurrent prostate cancer / Mark Pomerantz and Philip Kantoff -- Differential roles of androgen receptor in prostate development and cancer progression / Shuyuan Yeh ... [et al.] -- Imaging androgen receptor function in vivo / Michael Carey and Lily Wu -- Increased expression of genes converting adrenal androgens to testosterone in castration-recurrent prostate cancer / Steven P. Balk -- Androgen-metabolic genes in prostate cancer predisposition and progression / Juergen K.V. Reichardt and Ann W. Hsing -- Effect of steroid 5[alpha]-reductase inhibitors on markers of tumor regression and proliferation in prostate cancer / Lynn N. Thomas and Roger S. Rittmaster -- 5[alpha]-reductase isozymes in castration-recurrent prostate cancer / Mark A. Titus and James L. Mohler -- Improving intermittent androgen-deprivation therapy : OFF cycle and the role of steroid 5[alpha]-reductase inhibitors / Shubham Gupta, Daniel Shevrin, and Zhou Wang -- Insights from AR gene mutations / Grant Buchanan ... [et al.] -- Functional motifs of the androgen receptor / Elizabeth M. Wilson -- The role of the androgen receptor polyglutamine tract in prostate cancer : in mice and men / Diane M. Robbins -- The androgen receptor coactivator-binding interface / Eva Estébanez-Perpiñá and Robert J. Fletterick -- Co-regulators and the regulation of androgen receptor action in prostate cancer / Irina U. Agoulnik and Nancy L. Weigel -- Androgen receptor coregulators and their role in prostate cancer / Latif A. Wafa, Robert Snoek, and Paul S. Rennie -- Interaction of the androgen receptor ligand-binding domain with the n-terminal domain and with coactivators / Jan Trapman -- Multitasking and interplay between the androgen receptor domains / F.Claessens, T. Tanner, and A. Haelens -- Chromatin remodeling and androgen receptor-mediated transcription / Li Jia ... [et al.] -- Ligand-independent androgen receptor activity / Scott M. Dehm and Donald J. Tindall -- Role of IL-6 in regulating the androgen receptor / Zoran Culig and Alfred Hobisch -- The role of cyclic AMP in regulating the androgen receptor / Marianne D. Sadar --Cellular and molecular signatures of androgen ablation of prostate cancer / Clifford G. Tepper and Hsing-Jien Kung -- Tissue levels of androgens in castration-recurrent prostate cancer / James L. Mohler and Mark A. Titus -- Unique effects of wnt signaling on prostate cancer cells : modulation of the androgen signaling pathway by interactions of the androgen receptor gene and protein with key components of the canonical wnt signaling pathway / Matthew J. Tanner ... [et al.] -- The role of foxa proteins in the regulation of androgen receptor activity / David J. DeGraff ... [et al.] -- Androgen receptor as a licensing factor for DNA replication / Donald J. Vander Griend and John T. Isaacs -- Androgen-regulated genes in the prostate / Nigel Clegg and Peter S. Nelson -- Mapping the androgen receptor cistrome / Qianben Wang and Myles Brown -- Differential regulation of clusterin isoforms by the androgen receptor Tanya K. Day, Colleen C. Nelson, and Martin E. Gleave -- Androgen regulation of prostate cancer gene fusions / Rou Wang, Scott A. Tomlins, and Arul M. Chinnaiyan -- Androgens and the lipogenic switch in prostate cancer / Johannes V. Swinnen ... [et al.] -- Molecular biology of novel targets identified through study of castration-recurrent prostate cancer / Philip A. Watson and Charles L. Sawyers -- Selenium and androgen receptor in prostate cancer / Nagalakshmi Nadiminty and Allen C. Gao.
  • Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies. Understanding the functions of androgen-responsive genes and their regulation and deregulation in prostate cancer progression may lead to new approaches to prevent and treat prostate cancer patients. This book provides an up-to-date review of the overall androgen-responsive gene expression program and the regulation, function, and clinical relevance of both protein coding and non-coding androgen-responsive genes. Experts in the field of androgen action and prostate cancer research discussed the importance of DNA elements, chromatin structure, cellular signaling, and cell-cell interactions in the regulation of androgen-responsive genes in the context of prostate cancer progression, including the development of CRPC. This book is intended for individuals interested in cancer endocrinology and medical and healthcare professionals involved in prostate cancer research.
  • Angiogenesis inhibition 2010, Springer
    Angiopoietins / Yvonne Reiss -- HIF-1 alpha and cancer therapy / Mei Yee Koh, Tally R. Spivak-Kroizman, Garth Powis -- Chemokines / Andreas Hippe, Bernhard Homey, Anja Meuller-Homey -- Angiogenesis inhibition in cancer therapy / Iris Appelmann ... [et al.] -- Vascular integrins : therapeutic and imaging targets of tumor angiogenesis / Curzio Ruegg, Gian Carlo Alghisi -- PDGF and vessel maturation / Carina Hellberg, Arne Ostman, C.-H. Heldin -- Lymphangiogenesis in cancer : current perspectives / Rudiger Liersch ... [et al.] -- Compounds in clinical phase III and beyond / Torsten Kessler ... [et al.] -- Metronomic chemotherapy : principles and lessons learned from applications in the treatment of metastatic prostate cancer / Urban Emmenegger ... [et al.] -- Targeting inflammatory cells to improve anti-VEGF therapies in oncology / Hans-Peter Gerber, Ezogelin Olazoglu, Iqbal S. Gerwal -- Antibody-based vascular tumor targeting / Christoph Schliemann, Dario Neri -- Caveolae and cancer / Kerri A. Massey, Jan E. Schnitzer.
  • Part I: Angiogenesis in cancer -- Strategies to prolong the nonangiogenic dormant state of human cancer / George N. Naumov and Judah Folkman -- Vascular endothelial growth factor: basic biology and clinical implications / Napoleone Ferrara -- Angiogenesis in solid tumors / Rakesh K. Jain and Dan G. Duda -- Pathophysiologic role of VEGF in hematologic malignancies / Klaus Podar ... [et al.] -- Tumor microenvironment and angiogenesis / Cheryl H. Baker and Isaiah J. Fidler -- Part II: Targeting angiogenesis for cancer therapy -- Tyrosine kinase inhibitors of angiogenesis / Janessa J. Laskin and Alan B. Sandler -- Development of antiangiogenic monoclonal antibodies for cancer therapy / Zhenping Zhu and Daniel J. Hicklin -- Targeting fibroblast growth factor / fibroblast growth factor receptor system in angiogenesis / Marco Rusnati and Marco Presta -- Development of the VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and discovery of the next generation of angiogenesis targets / John S. Rudge ... [et al.] -- Proteinases and their inhibitors in angiogenesis / Yves A. DeClerck, Khalid Bajou, and Walter E. Laug -- Prostaglandins and COX-2: role in antiangiogenic therapy / Kristin Hennenfent, Daniel Morgensztern, and Ramaswamy Govindan -- Integrins, adhesion, and coadhesion inhibitors in angiogenesis / Abebe Akalu and Peter C. Brooks -- Conventional therapeutics with antiangiogenic activity / Christian Hafner, Thomas Vogt, and Albrecht Reichle -- Vascular disrupting agents / David J. Chaplin, Graeme J. Dougherty, and Dietmar W. Siemann -- Vascular and hematopoietic stem cells as targets for antiangiogenic therapy / Carlos Almeida Ramos, Hans-Georg Kopp, and Shahin Rafii -- Genetic strategies for targeting angiogenesis / Anita Tandle, Mijung Kwon, and Steven K. Libutti -- Identification of new targets using expression profiles / Thomas R. Burkard ... [et al.].; Part III: Translating angiogenesis inhibitors to the clinic -- Clinical trial design and regulatory issues / Ramzi N. Dagher and Richard Pazdur -- Surrogate markers for antiangiogenic cancer therapy / Darren W. Davis -- Noninvasive surrogates / Bruno Morgan and Mark A. Horsfield -- Pharmacodynamic markers in tissues / Darren W. Davis -- Blood-based biomarkers for VEGF inhibitors / Amado J. Zurita, Hua-Kang Wu, and John V. Heymach -- Part IV: Treatment of specific cancers with angiogenesis inhibitors -- Antiangiogenic therapy for colorectal cancer / Paulo M. Hoff and Everardo D. Saad -- Combined modality therapy of rectal cancer / Christopher G. Willett and Dan G. Duda -- Antiangiogenic therapy for breast cancer / Pablo M. Bedano ... [et al.] -- Antiangiogenic therapy for lung malignancies / David J. Stewart -- Antiangiogenic therapy for prostate cancer / Leslie K. Walker, Glenn Liu, and George Wilding -- Antiangiogenic therapy for hematologic malignancies / Karen W.L. Yee and Francis J. Giles -- Antiangiogenic therapy for gliomas / Heinrich Elinzano and Howard A. Fine -- Antiangiogenic therapy for Kaposi's sarcoma / Henry B. Koon, Liron Pantanowitz, and Bruce J. Dezube -- Antiangiogenic therapy for melanoma / Keith Dredge and Angus G. Dalgleish -- Sunitinib and renal cell carcinoma / Robert J. Motzer and Sakina Hoosen.
  • The concept of delivering 'magic bullets' to treat diseases was first proposed by Paul Erlich in the early 1900's. The realization of this concept for the treatment of cancer occurred in the late 1990's with the approval of monoclonal antibody therapies. The use of monoclonal antibodies conjugated (linked) to potent cytotoxic agents (antibody-drug conjugates, ADCs) for specifically delivering cytotoxics to cancer cells was an obvious extension of antibody-based therapy. ADCs have been under intense investigation for several decades; progress, however, has been limited due to toxicity or lack of improved efficacy compared to unconjugated cytotoxics. More recently, linker technology and target selection have advanced such that several ADCs and immunotoxins are undergoing clinical testing or are approved for use. This important volume gives the latest and most comprehensive information on the topic, describing different types of ADCs and immunotoxins for both hematologic and solid malignancies. Finally, the volume highlights the promise that this technology holds for diverse types of human cancer.
  • "This book covers clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. The second edition includes drugs that are currently in development. In addition, the text emphasizes the applications of synthetic and medicinal chemistry to the preparation of analogs with enhanced activities. Contributors also address the potential of novel drug discovery through the use of genome mining as well as the status of advanced development candidates. For each compound of class of compounds, the text provides information on the history, structure, mechanism of action, development, synthesis, medicinal chemistry, and clinical applications"-- Provided by publisher."The search for new lead compounds is a crucial element of modern pharmaceutical research. Natural products provided the only source of pharmaceuticals for thousands of years, and natural products have made enormous contributions to human health through compounds such as quinine, morphine, aspirin (a natural product analog), digitoxin, and many others. The potential of natural products as anticancer agents was recognized in the 1950's by the U. S. National Cancer Institute (NCI) under the leadership of the late Dr. Jonathan Hartwell, and the NCI has since made major contributions to the discovery of new naturally occurring anticancer agents through its contract and grant support, including an important program of plant and marine collections. Many, although not all, of the compound classes described in the following pages owe their origin in whole or in part to NCI support. In spite of the success of the natural products approach to anticancer drug discovery, as exemplified by the following chapters, in recent years their importance as a source of molecular diversity for drug discovery research and development has been overshadowed by newer chemical approaches currently in favor. These approaches include chemical ones which make heavy use of combinatorial chemistry, and biological ones such as manipulation of biosynthetic pathways of microbial metabolites through combinatorial biosynthetic techniques. It is thus worthwhile to review briefly the major reasons why natural products are so important. First, there is a strong biological and ecological rationale for plants and marine invertebrates to produce novel bioactive secondary metabolites"-- Provided by publisher.
  • Anticancer genes 2014, Springer
    "This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as "Anticancer Genes", are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells."--Publisher's website.
  • History of drug discovery : early evaluation studies and lessons learnt from them / Ahmad, Z., Makaya, N.H. and Grosset, J. -- Tuberculosis treatment trials past and present : old and new challenges / Nunn, N. -- The rifamycins : renewed interest in an old drug class / Burman, W., Dooley, K.E., and Nuermberger, E. -- Isoniazid pharmacokinetics and efficacy in adults and children / Donald, P.R. and Schaaf, H.S. -- Recent developments in the study of pyrazinamide : an update / Mitchison, D.A. and Zhang, Y. -- Experience with phase III clinical trials of antituberculosis drugs and regimens : conclusions and lessons for the future / Jindani, A. -- Tuberculosis recurrence : exogenous or endogenous? / Williams, M. ... [et al.] -- Second-line antituberculosis drugs : current knowledge, recent research findings and controversies / Schaaf, H.S., Seddon, J.A., and Caminero, J.A. -- Acquisition, transmission, and amplification of drug-resistant tuberculosis / Müller, B. ... [et al.] -- The treatment of tuberculosis in children -- Cruz, A.T. and Starke, J.R. -- Issues and challenges in the development of novel tuberculosis drug regimens / Erondu, N. and Ginsberg, A. -- Drug resistance in mycobacterium tuberculosis : molecular mechanisms and laboratory susceptibility testing / Bittger, E.C. -- The role of the mouse model in the evaluation of new antituberculosis drugs / Nuermberger, E.L. -- Current issues in tuberculosis pharmacokinetics / Egelund, E.F. and Peloquin, C.A. -- Pharmacological considerations of antitubercular agents in children / Goldman, J.L., Kearns, G.L., and Abdel-Rahman, S.M. -- Interactions between antituberculosis and antiretroviral agents / Mcilleron, H. and Khoo, S.H. -- Diabetes mellitus and tuberculosis treatment / Ruslami, R., Van Crevel, R. -- Early bactericidal activity of antituberculosis agents / Maritz, J.Z., Diacon, A.H., and Donald, P.R. -- Assessment of whole-blood bactericidal activity in the evaluation of new antituberculosis drugs / Wallis, R.S. -- Serial sputum colony counting in drug regimens / Sloan, D. and Davies, G. -- The evaluation of new antituberculosis drugs in children / Mcneeley, D.F. ... [et al.] -- A new era in tuberculosis treatment : what does the future hold? / Duncan, K.
  • APC proteins 2009, Springer
    APC and [beta]-catenin degradation -- Nuclear APC -- APC in cell migration -- The APC-EB1 interaction -- The role of APC in mitosis and in chromosome instability -- Role of APC and its binding partners in regulating microtubules in mitosis -- The adenomatous polyposis coli tumor -- Suppressor and Wnt signaling in the regulation of apoptosis -- APC and its modifiers in colon cancer -- Tissue-specific tumour suppression by APC -- Extra-colonic manifestations of familial adenomatous polyposis coli.
  • Apoptosis and cancer 2008, Springer Protocols
    Modulation of apoptosis to reverse chemoresistance /Gil Mor,Michele K. Montagna,andAyesha B. Alvero - -Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis /Suparna Mazumder,Dragos Plesca,andAlexandru Almasan - -Flow cytometry enumeration of apoptotic cancer cells by apoptotic rate /David Diaz... [et al.] - -Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection /Dan-Arin Silasi... [et al.] - -Flow cytometric detection of activated caspase-3 /Richard FoxandMartine Aubert - -The chemofx® assay : an ex vivo chemosensitivity and resistance assay for predicting patient response to cancer chemotherapy /Stacey L. Brower,Jeffrey E. Fensterer,andJason E. Bush --Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines /Ayesha B. Alvero,Michele K. Montagna,andGil Mor - -Assessing expression of apoptotic markers using large cohort tissue microarrays /Elah Pick,Mary M. McCarthy,andHarriet M. Kluger --Mitochondria potential, bax "activation," and programmed cell death /C. Michael KnudsonandNicholas M. Brown --In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases /Brian W. Lee... [et al.] - -Caspase activity assays /Andrew L. Niles,Richard A. Moravec,andTerry L. Riss - -Multiplex caspase activity and cytotoxicity assays /Andrew L. Niles,Richard A. Moravec,andTerry L. Riss - -Homogeneous, bioluminescent proteasome assays /Martha A. O'Brien... [et al.] - -A simple method for profiling mirna expression /Jia-Wang WangandJin Q. Cheng - -Apoptotic caspase activation and activity /Jean-Bernard DenaultandGuy S. Salvesen - -Biochemical analysis of the native trail death-inducing signaling complex /Henning WalczakandTobias L. Haas - -Laser microdissection sample preparation for RNA analyses /Christopher J. Vega.
  • v. 2, 2007 Springer
    BCR-ABL and human cancer / Maria Pérez-Caro and Isidro Sánchez-Garcia -- Angiogenesis and cancer / Yohei Maeshima -- Metastasis: the evasion of apoptosis / Christine E. Horak ... [et al.] -- Carcinogenesis: balance between apoptosis and survival pathways / Dean G. Tang and James P. Kehrer -- Aberrations of DNA damage checkpoints in cancer / Marikki Laiho -- c-Myc, apoptosis, and disordered tissue growth / Michael Khan and Stella Pelengaris -- Role of lysophospholipids in cell growth and survival / Xianjun Fang and Sarah Spiegel -- Alternative use of signaling by the [beta] GBP cytokine in cell growth and cancer control: from surveillance to therapy / Livio Mallucci and Valerie Wells -- Control nodes linking the regulatory networks of the cell cycle and apoptosis / Baltazar D. Aguda, Wee Kheng Yio, and Felicia Ng -- Regulation of NF-[kapa]B function: target for drug development / Daniel Sliva and Rakesh Srivastava -- 5-fluorouracil: molecular mechanisms of cell death / Daniel B. Longley and Patrick G. Johnston -- Apoptosis-inducing cellular vehicles for cancer gene therapy: endothelial and neural progenitors / Gergely Jarmy ... [et al.] -- Apoptosis and cancer therapy / Maurice Reimann and Clemens A. Schmitt -- Coupling apoptosis and cell division control in cancer: the survivin paradigm / Dario C. Altieri -- Clinical significance of histone deacetylase inhibitors in cancer / Sharmila Shankar and Rakesh K. Srivastava.
  • The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy.
  • Apoptosome 2010, Springer
  • Ch. 1. Cancer terminator viruses and approaches for enhancing therapeutic outcomes -- Ch. 2. Adenovirus strategies for tissue-specific targeting -- Ch. 3. Syrian hamster as an animal model to study oncolytic adenoviruses and to evaluate the efficacy of antiviral compounds -- Ch. 4. Design of improved oncolytic adenoviruses -- Ch. 5. The development of transcription-regulated adenoviral vectors with high cancer-selective imaging capabilities -- Ch. 6. Adenovirus-based immunotherapy of cancer, promises to keep -- Ch. 7. Cancer treatment with gene therapy and radiation therapy -- Ch. 8. Oncolytic adenoviruses for cancer immunotherapy, data from mice, hamsters, and humans -- Index.
  • Aromatase inhibitors 2006, Springer
  • Atlas of Brain and Spine Oncology Imaging presents a comprehensive visual review of pathologic disease variations of cancers of the brain and spine through extensive radiologic images. The focus of the book is on algorithmic strategies for identifying neoplastic pathologies commonly found in brain and spinal tumors through a visual representation of the variety of appearances that each neoplasm takes, within both benign and malignant manifestations.
  • Diagnostic Techniques in Gastrointestinal Disease -- Device and Equipment for Endoscopic Therapy -- Endoscopic Mucosal Resection (EMR) -- Endoscopic Submucosal Dissection (ESD) -- Endoscopic Resection for Submucosal Tumors -- Tunnel Endoscopic Surgery.
  • This book covers all of the diagnostic areas where FNAC is used today. This includes palpable lesions and lesions sampled using various radiological methods, and correlations with ancillary examinations detailed on an entity-by-entity basis. As well as being a complete atlas of the facts and findings important to FNAC, this atlas is a guide to diagnostic methods that optimize health care. The interaction of the cytologist or cytopathologist with other specialists (radiologists, oncologists and surgeons) involved in the diagnosis and treatment of patients with suspicious mass lesions is emphasized and illustrated throughout. ? With contributions from experts in the field internationally and abundant colour images Atlas of Fine Needle Aspiration Cytology provides a comprehensive and up-to-date guide to FNAC for pathologists, cytopathologists, radiologists, oncologists, surgeons and others involved in the diagnosis and treatment of patients with suspicious mass lesions.
  • The Atlas of Genitourinary Oncological Imaging presents a comprehensive visual review of appearances for normal anatomy and oncological diseases in the genitourinary system using over 900 radiological images and illustrations. The book presents current imaging techniques and discusses the role of imaging in pre-treatment staging and post-treatment follow-up. Diseases discussed include kidney, adrenal gland, upper tract, bladder, prostate, testes, and pediatric malignancies. Individual chapters include normal anatomy, imaging techniques, and pathology of each cancer type. The staging of the malignancy and what to include in the radiology report are discussed, and expected and complicated postoperative and post-treatment findings and recurrence are presented. Dedicated chapters on interventional and radiation therapy discuss their unique role in the management and treatment of oncology of the genitourinary system. Additionally, a chapter on chemotherapy toxicities discusses drug reaction treatment therapies unique to the genitourinary system.Edited and written by radiologists from the genitourinary disease management team at Memorial Sloan-Kettering Cancer Center, the Atlas of Genitourinary Oncological Imaging is an ideal resource for radiology and urology trainees seeking a review of the basics and for practicing radiologists looking for answers to challenging cases confronted in daily practice.
  • This book provides a comprehensive visual review of pathologic disease variations of the five main types of gynecologic cancers: ovarian, endometrial, cervical, vaginal, and vulvar. Through the use of cross-sectional imaging modalities, including computed tomography, magnetic resonance imaging, ultrasound, and positron emission tomography, it depicts normal anatomy as well as common gynecological tumors. For each type of cancer, aspects such as primary staging, recurrence patterns, and findings from different yet complementary imaging modalities are explored. Atlas of Gynecologic Oncology Imaging presents a coherent perspective of the roles of standard and cutting-edge imaging techniques in gynecologic oncology via a multidisciplinary approach to cancer care. Featuring over 600 images, this book is a valuable resource for diagnostic radiologists, radiation oncologists, and gynecologists.
  • Male genital disorders represent a common issue in medical practice, especially in the dermatological setting. Correct clinical evaluation of these disorders is essential when addressing the diagnosis, which in some cases may require histopathological confirmation. Depending on the disease, early diagnosis may be not only lifesaving, but also of fundamental importance to the planning of successful treatment. This atlas introduces the most common penile diseases, along with more rarely encountered ones. It provides invaluable guidance on clinical diagnosis by highlighting prominent clinical features and presenting particular videodermatoscopy findings when these are indicative of the diagnosis. In addition, for each condition the most appropriate treatment is proposed, taking into account recent therapeutic advances of proven benefit.
  • Anatomy of the breast -- Techniques and positioning in mammography -- An approach to mammographic analysis -- Circumscribed masses -- Indistinct and spiculated masses -- Analysis of calcification -- Prominent ductal patterns -- Asymmetry and architectural distortion -- The thickened skin pattern -- The axilla -- The male breast -- The postsurgical breast -- The augmented breast -- Galactography -- Needle localization -- Percutaneous breast biopsy -- The roles of ultrasound and magnetic resonance imaging in breast imaging.
  • Lymphangiomatosis -- Pleuropulmonary blastoma -- Congenital pulmonary myofibroblastic tumor -- Alveolar adenoma -- Uncommon endobronchial surface tumors -- Mucous gland adenoma -- Pleomorphic adenoma -- Mucoepidermoid tumor -- Adenoid cystic carcinoma -- Inflammatory polyps -- Inflammatory pseudotumor -- Pulmonary chondroma -- Pulmonary hamartoma -- Localized fibrous tumor -- Lipomas and liposarcomas -- Cystic lymphangioma -- Lymphangioleiomyomatosis -- Epithelioid hemangioendothelioma -- Pulmonary artery sarcoma -- Synovial sarcoma -- Marginal zone B-cell lymphoma (maltoma) -- Diffuse large B-cell lymphoma -- Lymphomatoid granulomatosis -- Langerhans cell histiocytosis -- Typical and atypical carcinoids -- Teratoma -- Melanoma -- Thymoma -- Glomus tumor of the lung -- Sclerosing hemangioma -- Preinvasive disease -- Squamous cell carcinoma -- Adenocarcinoma -- Large cell carcinoma -- Small cell carcinoma -- Adenosquamous carcinoma -- Bronchioloalveolar carcinoma -- Large cell neuroendocrine carcinoma -- Sarcomatoid carcinoma -- Pulmonary blastoma -- Metastatic tumors.
  • Part 1. Pilocytic astrocytoma and Pilomyxoid Astrocytoma -- Pilocytic astrocytoma and Pilomyxoid Astrocytoma / Christine Fuller and Sonia Narendra -- Pleomorphic Xanthoastrocytoma / Christine E. Fuller -- Infiltrative Astrocytomas (Diffuse Astrocytoma, Anaplastic Astrocytoma, Glioblastoma) / Christine E. Fuller -- Oligodendroglial Tumors / Christine E. Fuller -- Ependymal Tumors / Christine E. Fuller, Sonia Narendra and Ioana Tolicica -- Introduction and Overview of Brain Tumors / Adekunle M. Adesina -- Part 2. Embryonal Neuroepithelial Tumors -- Central Nervous System Primitive Neuroectodermal Tumors and Medulloepithelioma / Adekunle M. Adesina, J. Hunter and L. Rorke-Adams -- Medulloblastoma / Adekunle M. Adesina and J. Hunter -- Atypical Teratoid Rhabdoid Tumor / Adekunle M. Adesina, J. Hunter and L. Rorke-Adams -- Part 3. Tumors of the Meninges -- Meningiomas / Christine Fuller and Brian Pavlovitz -- Hemangiopericytoma and Other Mesenchymal Tumors / Christine E. Fuller -- Melanocytic Lesions / Christine E. Fuller -- Hemangioblastoma -- Christine E. Fuller -- Part 4. Tumors of Cranial and Spinal Nerves -- Schwannoma / Tarik Tihan -- Neurofibroma / Tarik Tihan -- Malignant Peripheral Nerve Sheath Tumors / Tarik Tihan -- Part 5. Neuronal and Mixed Neuronal-glial Tumors -- Desmoplastic Infantile Astrocytoma and Ganglioglioma / Adekunle M. Adesina -- Dysembryoplastic Neuroepithelial Tumor / Adekunle M. Adesina and Ronald A. Rauch -- Ganglioglioma and Gangliocytoma / Adekunle M. Adesina and Ronald A. Rauch -- Central Neurocytoma and Extraventricular Neurocytoma / Adekunle M. Adesina and Ronald A. Rauch -- Papillary Glioneuronal Tumor / M. Rivera-Zengotita, A. Illner and Adekunle M. Adesina -- Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle / M. Rivera-Zengotita and Adekunle M. Adesina -- Malignant Epithelioid Glioneuronal Tumor / M. Rivera-Zengotita, R. Rauch and Adekunle M. Adesina -- Paraganglioma / A. Rivera and Adekunle M. Adesina -- Part 6. Neurocutaneous Syndromes -- Neurofibromatosis 1 / Tarik Tihan -- Neurofibromatosis 2 / Tarik Tihan -- Von Hippel-Lindau Disease / Tarik Tihan and Adekunle M. Adesina -- Tuberous Sclerosis Complex / Tarik Tihan and Adekunle M. Adesina -- L'hermitte-Duclos Disease and Cowden Disease / T. Hidehiro, S. Hiroyoshi and Adekunle M. Adesina -- Part 7. Tumors in the Region of the Pituitary Fossa -- Pituitary Tumors / Tarik Tihan and Christine E. Fuller -- Craniopharyngioma / Tarik Tihan -- Part 8. Choroid Plexus Neoplasms -- Choroid Plexus Neoplasms / Christine E. Fuller, Sonia Narendra and Ioana Tolocica -- Part 9. Pineal Based Tumors -- Pineal Parenchymal Tumors / Tarik Tihan -- Part 10. Germ Cell Tumors -- Germ Cell Tumors / Tarik Tihan -- Part 11. Paraneoplastic Disorders -- Paraneoplastic Disorders of the Central Nervous System / Christine E. Fuller and Sonia Narendra -- Part 12. Tumours of the Haematopoietic System -- Malignant Lymphoma / Adekunle M. Adesina -- Histiocytic Tumors / A. Mukherjee and Adekunle M. Adesina -- Part 13. Interesting/Challenging Cases and Exercises in Pattern Recognition -- Case Studies / Adekunle M. Adesina, Christine E. Fuller and Lucy Rocke-Adams.
  • This richly illustrated book presents the pediatric applications of PET/CT in the full range of scenarios frequently encountered in a professional setting. It opens with a thorough introduction covering the fundamental science and the clinical basis for use of PET/CT in this age group. Pitfalls and artifacts are examined, and normal variations and benign findings are carefully described. Each subsequent chapter addresses the role of PET/CT with different radiopharmaceuticals in the evaluation and management of a specific disease. The full range of oncological diseases is covered, including the rare ones. Succinct descriptions of clinical cases are included and, when appropriate, comparisons are made with other modalities. In addition, the role of PET/CT in biopsy guidance and in radiation therapy planning is explained. This book will be invaluable for residents and practitioners in nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology
  • This new project on PET/MR imaging in oncology includes digital interactive software matching the cases in the book. The interactive version of the atlas is based on the latest web standard, HTML5, ensuring compatibility with any computer operating system as well as a dedicated version for Apple iPad and iPhone. The book opens with an introduction to the principles of hybrid imaging that pays particular attention to PET/MR imaging and standard PET/MR acquisition protocols. A wide range of illustrated clinical case reports are then presented. Each case study includes a short clinical history, findings, and teaching points, followed by illustrations, legends, and comments. The multimedia version of the book includes dynamic movies that allow the reader to browse through series of rotating 3D images (MIP or volume rendered), display blending between PET and MR, and dynamic visualization of 3D image volumes. The movies can be played either continuously or sequentially for better exploration of sets of images. The editors of this state-of-the-art publication are key opinion leaders in the field of multimodality imaging. Professor Osman Ratib (Geneva) and Professor Markus Schwaiger (Munich) were the first in Europe to initiate the clinical adoption of PET/MR imaging. Professor Thomas Beyer (Zurich) is an internationally renowned pioneering physicist in the field of hybrid imaging. Individual clinical cases presented in this book are co-authored by leading international radiologists and nuclear physicians experts in the use of PET and MRI.
  • 1. How to Use This Atlas -- 2. Normal Skin -- 3. Basal Cell Carcinoma -- 4. Infiltrative Basal Cell Carcinoma -- 5. Differentiating Basal Cell Carcinoma from Normal and Benign Histologic Findings -- 6. Adnexal Tumors -- 7. Microcystic Adnexal Carcinoma -- 8. Differentiating Infiltrative Basal Cell Carcinoma from Other Tumors -- 9. Squamous Cell Carcinoma In Situ and Actinic Keratoses -- 10. Squamous Cell Carcinoma -- 11. Differentiating Squamous Cell Carcinoma from other entities -- 12. Dermatofibrosarcoma Protuberans -- 13. Other Non-melanocytic Skin Cancer -- 14. Pitfalls and Incidental Findings -- 15. Artifacts.
  • Atlas of skin cancers 2011, Springer
    The incidence of skin cancer has risen rapidly in recent decades, and patients often present initially to practitioners in many different specialties. Because skin cancer can vary in clinical appearance, even dermatologists may experience difficulty in reaching a clinical diagnosis. For primary care physicians and physician extenders (physician assistants, nurses, and nurse practitioners), who have had very little or no formal training in dermatology, the task can be still more daunting. In this atlas, the authors set out to provide a practical resource that will help improve the 'visual vocabulary' of physicians and physician extenders, helping them identify lesions that should be biopsied.--Abstract (excerpt).
  • Soft tissue tumors are a large and heterogeneous group of tumors and pseudotumors with a spectrum of behavior from benign to frankly malignant. This Atlas of Soft Tissue Tumor Pathology provides an overview of reactive, pseudoneoplastic, benign and intermediate neoplasms, sarcomas and related conditions arising in subcutaneous and deep soft tissues. Emphasis is placed on microscopic appearances with correlation with gross diagnostic findings where relevant. In addition, the immunohistochemical and molecular genetic features of the major soft tissue tumor subtypes are presented.
  • Atlas of thyroid lesions 2011, Springer
    Physical and technical essentials -- Ultrasound features of thyroid lesions -- Nodular or colloid goiter, hyperplasia, and cysts -- Follicular adenoma and follicular thyroid carcinoma -- Oncocytic nodule/Hurtle cell tumors -- Follicular variant of papillary thyroid carcinoma -- Papillary thyroid carcinoma -- Medullary thyroid carcinoma -- Anaplastic carcinoma -- Lymphoma and plasmacytoma -- Thyroiditis -- Metastases -- Regional lymph node metastases.
  • Autophagy and cancer 2013, Springer
    This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.
  • Bacteria and cancer 2012, Springer
  • Basic radiation oncology 2010, Springer
    Radiation physics -- Radiobiology -- Clinical radiation oncology -- Central nervous system tumors -- Head and neck cancers -- Lung cancer -- Breast cancer -- Genitourinary system cancers -- Gynecological cancers -- Gastrointestinal system cancers -- Soft tissue sarcoma -- Skin cancer -- Lymphomas and total body irradiation.
  • Basics of oncology 2009, Springer
  • BCL-2 protein family 2010, Springer
    Homeostatic functions of BCL-2 proteins beyond apoptosis / Nika N. Danial, Alfredo Gimenez-Cassina, and Daniel Tondera -- Alternative functions of the BCL-2 protein family at the endoplasmic reticulum / Diego Rojas-Rivera ... [et al.] -- BH3-only proteins and their effects on cancer / Thanh-Trang Vo and Anthony Letai -- Endoplasmic reticulum stress and BCL-2 family members / Ross T. Weston and Hamsa Puthalakath -- Targeting survival pathways in lymphoma / Luca Paoluzzi and Owen A. O'Connor -- The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis / Maria Eugenia Soriano and Luca Scorrano -- Noncanonical functions of BCL-2 proteins in the nervous system / Heather M. Lamb and J. Marie Hardwick -- Mitochondria on guard : role of mitochondrial fusion and fission in the regulation of apoptosis / Mariusz Karbowski.
  • Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.
  • Sect. 1. Head and neck. Head and neck cancer / Barbara A. Conley ... [et al.] -- Sect. 2. Thorax. Non-small cell lung cancer / Anne M. Horgan and Oscar S. Breathnach -- Small cell lung cancer / Neelima Denduluri and Martin E. Gutierrez -- Sect. 3. Digestive system. Esophageal cancer / Gregory D. Leonard, David P. Kelsen, and Carmen J. Allegra -- Gastric cancer / M. Wasif Saif -- Biliary tract cancer / Gregory D. Leonard, Eileen M. O'Reilly, and Carmen J. Allegra -- Primary cancers of the liver / Gregory D. Leonard, William R. Jarnagin, and Carmen J. Allegra -- Colorectal cancer / George P. Kim, Chris H. Takimoto, and Carmen J. Allegra -- Pancreatic cancer / George P. Kim, James L. Gulley, Chris H. Takimoto -- Anal cancer / M. Wasif Saif -- Other gastrointestinal tumors / M. Wasif Saif -- Sect. 4. Breast. Breast cancer / Hamid R. Mirshahidi and Jame Abraham -- Sect. 5. Genitourinary. Renal cell cancer / Hung T. Khong, Christopher Klebanoff, and Susan Bates --Prostate cancer / James L. Gulley and William L. Dahut -- Bladder cancer / Manish Agarwal and William L. Dahut -- Testicular carcinoma / Avi S. Retter and Barnett S. Kramer -- Sect. 6. Gynecologic. Ovarian cancer / Eddie Reed and Ramin Altaha -- Endometrial cancer / Christina M. Annunziasta and Michael J. Birrer -- Cervical cancer / Edwin M. Posades and Herbert L. Kotz -- Vulvar cancer / Christina M. Annunziasta and Michael J. Birrer -- Sect. 7. Musculoskeletal. Sarcomas and malignancies of the bone / Patrick J. Mansky and Lee Helman -- Sect. 8. Skin cancer. Skin cancers and melanoma / Upendra P. Hegde and Barry Gause -- Sect. 9. Hematologic malignancies. Acute leukemias / Michael Craig, Jame Abraham, and Brian P. Monahan -- Chronic leukemias / Muzaffar H. Quazilbash and Michael J. Keating -- Chronic myeloid leukemia / Muzaffar H. Quazilbash and Jorge E. Cortes -- Myeloproliferative diseases / Manish Monga and Marcel P. Devetten --Multiple myeloma / Sattva S. Neelapu and Cynthia E. Dunbar -- Non-Hodgkin lymphoma / Martin Gutierrez, Richard F. Little, and Wyndham H. Wilson -- Hodgkin lymphoma / Gisa Schun, Jame Abraham, and Marcel P. Devetten -- Hematopoietic stem cell transplantation / Michael Craig, Jame Abraham, and Richard W. Childs -- Sect. 10. Other malignancies. Acquired immunodeficiency syndrome-related malignancies / Pallavi P. Kumar and Richard F. Little -- Carcinoma of unknown primary / Hung T. Khong -- Central nervous system tumors / Patrick J. Mansky, J. Paul Duic, and Howard A. Fine -- Endocrine tumors / Michael E. Menefee and Tito Fojo -- Sect. 11. Supportive care. Hematopoietic growth factors / Philip M. Arlen and James L. Gulley -- Infectious complications in oncology / Sarah M. Wynne and Juan C. Gea-Banacloche -- General principles of cancer pain management / Jason R. Beckrow and Richard A. Messmann --Oncologic emergencies and paraneoplastic syndromes / Muhammad K. Siddique and Richard A. Messmann -- Psychopharmacologic management in oncology / Donald L. Rosenstein, Maryland Pao, and June Cai -- Management of emesis in oncology / David R. Kohler -- Nutrition for oncology patients / Marnie Dobbin -- End-of-life care / Jane Carter -- Sect. 12. Targeted treatments and complimentary and alternative medicine. Targeted therapies / James L. Gulley and Gregory Curt -- Complementary and alternative medicine in oncology / Patrick J. Mansky, Dawn b. Wallerstedt, and Marc R. Blackman -- Sect. 13. Common procedures and chemotherapy drugs. Central venous access devices / Deborah C. Gutierrez and Naomi P. O'Grady -- Procedures in medical oncology / Suzanne G. Demko and Kerry Ryan -- Anticancer agents / Thomas E. Hughes.
  • The second edition of this book is intended as a definitive text on biliary tract and gallbladder cancers. Specifically, it will serve as a single-source reference on the current knowledge base for the multidisciplinary management of such cancers and thus covers epidemiological, surgical, radiotherapy, and chemotherapy approaches. Akey feature is the demonstration of the impact of cutting-edge technical knowledge on treatment; for example, interventional radiology techniques, novel surgical approaches, and image-guided radiation therapy are all extensively discussed. Diagnosis is also considered in detail, with coverage of novel serum biomarkers, pathologic staging, molecular profiling, and the full range of current and emerging imaging strategies. Further chapters are devoted to epidemiology, the role of growth factor pathways and signal transduction, and histopathology and molecular pathogenesis. Experienced practitioners in a range of specialties will find this amply illustrated book to be an invaluable source of information on the newest diagnostic and treatment techniques in biliary tract and gallbladder cancer, yet it is also sufficiently concise to offer an introduction to the field for students and community practitioners.
  • Monitoring the burden of cancer in the United States -- Cancer biology and nutrigenomics -- Cellular cancer processes and their molecular targets -- Nutrigenetics: the relevance of polymorphisms -- Diet and epigenetics -- Nutrient signaling-protein kinase to transcriptional activation -- Dietary energy balance, calorie restriction, and cancer prevention -- Fiber and microbially generated active components -- Gut microbiota, probiotics, prebiotics and colorectal cancer -- Meats, protein and cancer -- Saturated fatty acids and cancer -- Conjugated linoleic acid and cancer -- Cancer and n-3PUFAs: the translational connection -- n-6 polyunsaturated fatty acids and cancer -- Carotenoids -- Vitamin A -- Vitamin D and cancer chemoprevention -- Folate -- Selenium -- Calcium and cancer -- Iron and cancer -- Zinc in cancer development and prevention -- Cruciferous vegetables, isothiocyanates, indoles, and cancer prevention -- Garlic and cancer prevention -- Mammary and prostate cancer chemoprevention and mechanisms of action of resveratrol and genistein in rodent models -- Cancer prevention by catechins, flavonols, and procyanidins -- Mechanisms of action of isoflavones in cancer prevention -- The anticarcinogenic properties of culinary herbs and spices -- Cancer prevention with berries: role of athocyanins -- Pomegranate -- Alcohol and cancer: biological basis -- Aryl hydrocarbon receptor-mediated carcinogenesis and modulation by dietary xenobiotic and natural ligands -- Opportunities and challenges for communicating food and health relationships to American consumers.
  • The emergence of bioinformatics : historical perspective, quick overview and future trends / Christos A. Ouzounis -- The statistical design and interpretation of microarray experiments / Kevin K. Dobbin and Richard M. Simon -- Whole-genome analysis of cancer / Steven A. Enkemann ... [et al.] -- Bioinformatics approaches to the analysis of the transcriptome of animal models of cancer / Mark J. Hoenerhoff ... [et al.] -- Significance of aberrant expression of miRNAs in cancer cells / George A. Calin ... [et al.] -- Proteomic methods in cancer research / Scot Weinberger and Egisto Boschetti -- Comprehensive genomic profiling for biomarker discovery for cancer detection, diagnostics and prognostics / Xiaofeng Zhou ... [et al.] -- Gene expression profiling of the leukemias : oncogenesis, drug responsiveness, and prediction of clinical outcome / Lars Bullinger, Hartmut Dohner, and Jonathon R. Pollack -- Personalized medicine in the clinical management of colorectal cancer / Anthony El-Khoueiry and Heinz Josef Lenz -- PIK3CA gene alterations in human cancers / Sérgia Velho, Carla Oliveira, and Raquel Seruca.
  • Biology of oral cancer 2014, CRCnetBASE
    "Cancer is a class of disease or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues. One new approach in dealing with cancer is through apoptotic regulators, which is the process of controlling cell growth by abnormally prolonging cell survival, facilitating the accumulation of transforming mutations and promoting resistance. This book uses oral cancers as the specific means to demonstrate this technique with this particular type of cancer, which is quite prevalent (and deadly) in India and other parts of Asia, in particular"--Provided by publisher.
  • Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon -- Analytical aspects of biomarker immunoassays in cancer research / C. G. J. (Fred) Sweep, Chris M. G. Thomas and Manfred Schmitt -- Tissue microarrays: state-of-the-art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik -- Gene expression profiling with DNA microarrays / Michele De Bortoli and Nicoletta Biglia -- Assays for gene amplification / Chungyeul Kim, Yongkuk Song, and Soonmyung Paik -- Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori -- Urokinase-type plasminogen activator and PAI-1 / Michael J. Duffy -- Predictive value of c-erbb-2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns -- Erb-b-2 as a therapeutic target / Robert Mass -- The epidermal growth factor receptor pathway as a selective -- Molecular-targeting treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora -- P-53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz -- Occult metastatic cells in breast cancer patients / Stephan Braun, Julia Seeber, and Christian Marth -- Circulating HER-2/neu / Allan Lipton ... [et al.] -- Circulating vascular endothelial growth factor / Roberta Sarmiento ... [et al] -- Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote -- New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini -- Index.
  • Biosensors and cancer 2013, CRCnetBASE
    Functional optical imaging-based biosensors / Pablo Iglesias and Jose A. Costoya -- Use of a surface plasmon resonance (SPR) biosensor to characterize zwitterionic coatings on SiO2 for cancer biomarker detection / Norman D. Brault, Shaoyi Jiang, and Qiuming Yu -- Microcantilever-based biosensor array for tumor angiogenic marker detection / Riccardo Castagna and Carlo Ricciardi -- Electrochemical DNA biosensors at the nanoscale / Rosa Letizia Zaffino ... [et al.] -- Aptamer-based biosensors for cancer studies / Ilaria Palchetti and Marco Mascini -- Fluorescent biosensors for cancer cell imaging and diagnostics / May C. Morris -- Electrical and electrochemical immunosensor for cancer study / Seung Yong Lee and Seung Yong Hwang -- Multifunctional nanobiosensors for cancer / Dai-Wen Pang and Er-Qun Song -- Silicon nanowire biosensor for cancer markers / Yang-Kyu Choi and Chang-Hoon Kim -- DNA-electrochemical biosensors and oxidative damage to DNA : application to cancer / Victor Constantin Diculescu and Ana Maria Oliveira Brett -- Asparaginase-based asparagine biosensors and their application to leukemia / Neelam Verma and Kuldeep Kumar -- Breast cancer detection using surface plasmon resonance-based biosensors / Chii-Wann Lin and Chia-Chen Chang -- Detection of miRNA with silicon nanowire biosensors / Guo-Jun Zhang -- Biosensors for BCR-ABL activity and their application to cancer / Yusuke Ohba ... [et al.] -- Optical fiber nanobiosensor for single living cell detections of cancers / Xin Ting Zheng and Chang Ming Li -- Microfluidic biosensors for thyroglobulin detection and application to thyroid cancer / Seokheun Choi and Junseok Chae -- Optical biosensors and applications to drug discovery and development in cancer research / Carlo Bertucci and Angela De Simone -- Single-chain fragment variable recombinant antibodies and their applications in biosensors for cancer diagnosis / Xiangqun Zeng and Ray Mernaugh -- DNA biosensor for rapid detection of anticancer drugs / Sigen Wang and Ruili Wang -- Using UV light to engineer biosensors for cancer detection : the case of prostate specific antigen / Maria Teresa Neves-Petersen, Antonietta Parracino, and Steffen B. Petersen.
  • Biosimilars 2013, Springer
    Biologicals' Characteristics / K. Ho and J.-H. Trouvin --From the Biosimilar Concept to the Marketing Authorisation / M. Pavlovic and J.-L. Prugnaud --Immunogenicity / J.-L. Prugnaud --Substitution and Interchangeability / J.-L. Prugnaud --G-CSFs: Onco-Hematologist's Point of View / D. Kamioner --The Oncologist's Point of View / C. Chouaïd --Biosimilars: Challenges Raised by Biosimilars: Who is Responsible for Cost and Risk Management? / F. Megerlin.
  • Central Nervous System Tumors /Paolo Aloisi, Francesco Martella, Davide Cerone and Giampiero Porzio --Head and Neck Tumours /Keith D. Hunter and Robert Bolt --Thyroid Cancer /Laura D. Locati, Angela Greco, Maria Grazia Borrello, Maria Luisa Carcangiu and Paolo Bossi, et al. --Targeted Therapies for Non-small-Cell Lung Cancer /Giulio Metro and Lucio Crinò --Non-Hodgkin's Lymphomas /Roberta Zappasodi and Massimo Di Nicola --Leukemias /Lia Ginaldi and Massimo De Martinis --Breast Cancer /Nadia Rucci, Luca Ventura and Anna Teti --Oesophago-Gastric Cancer /Alex M. Reece-Smith, Simon L. Parsons and Sue A. Watson --Colorectal Cancer /David N. Church, Rachel Susannah Midgley and David J. Kerr --Hepatocellular Carcinoma /Yasunori Minami and Masatoshi Kudo --Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma /Laura S. Schmidt --Bladder Cancer /Andrea Tubaro, Daniele Santini, Cosimo De Nunzio, Alice Zoccoli and Michele Iuliano --Biomarkers in Prostate Cancer /Mauro Bologna and Carlo Vicentini --Ovarian Cancer /Jessica Wangui Oribabor, Allison Ambrosio, Cesar M. Castro and Michael J. Birrer --Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer /Annekathryn Goodman, Leslie S. Bradford and Leslie A. Garrett --Biotargets in Sarcomas: The Past, Present, and a Look into the Future /Vivek Subbiah and Razelle Kurzrock --Melanoma and Other Skin Cancers /Kim H. T. Paraiso, Jobin K. John and Keiran S. M. Smalley --Molecular Pathology of Cancer Metastasis: Suggestions for Future Therapy /Adriano Angelucci and Edoardo Alesse --Current and Future Developments in Cancer Therapy Research: miRNAs as New Promising Targets or Tools /Marilena V. Iorio, Patrizia Casalini, Claudia Piovan, Luca Braccioli and Elda Tagliabue.
  • Bladder cancer 2010, Springer
  • Bladder tumors 2011, Springer
  • Blasenkarzinom 2005, Springer
  • Bone and cancer 2009, Springer
  • Bone cancer. 1st ed. 2010, ScienceDirect
    Chapter 1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases / Esther I. Hauben, Pancras C.W. Hogendoorn -- Chapter 2. Tumor-Bone Cell Interactions in Bone Metastases / Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise -- Chapter 3. Early Bone Metastasis-Associated Molecular and Cellular Events / Philippe Clézardin -- Chapter 4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways / Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard J. Murrills, Peter V.N. Bodine -- Chapter 5. Osteoclast Differentiation and Function / Luis Filgueira -- Chapter 6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease / Maria Grano, Giacomina Brunetti, Silvia Colucci -- Chapter 7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation / Blandine Ruhin, Frédéric Lézot, Aymann Bouattour, Sonia Ghoul-Mazgar, Ariane Berdal, Vianney Descroix -- Chapter 8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer / Frédéric Blanchard, Emmanuelle David, Bénédicte Brounais -- Chapter 9. Proteases and Therapeutic Approaches of Bone Tumors / Velasco C. Ruiz, Y. Fortun, D. Heymann, M. Padrines -- Chapter 10. Bone Remodeling Markers and Bone Cancer / Markus J. Seibel -- Chapter 11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors / Suvi Savola, Tom Böhling, Sakari Knuutila -- Chapter 12. Cytogenetics of Bone Tumors / Jiyun Lee, Mallory Martin, Shibo Li -- Chapter 13. Genetic Aspects of Bone Tumors / Shamini Selvarajah, Maria Zielenska, Jeremy A. Squire, Paul C. Park -- Chapter 14. Proteomics of Bone Cancer / Stephanie Byrum, Eric R. Siegel, Sudeepa Bhattacharyya, Larry J. Suva -- Chapter 15. Genomic and Proteomic Profiling of Osteosarcoma / Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau -- Chapter 16. Molecular Pathology of Osteosarcoma / Walter C. Bell, Gene P. Siegal -- Chapter 17. Technical Aspects: How Do We Best Prepare Bone Samples for Proper Histological Analysis? / Daniel Chappard -- Chapter 18. Osteoclast-rich Lesions of Bone: A Clinical and Molecular Overview / Adrienne M. Flanagan, Roberto Tirabosco, Panagiotis D. Gikas -- Chapter 19. Recent Advances in the Biology of Bone Tumors and New Diagnostic Tools / Gonzague de Pinieux, Corinne Bouvier -- Chapter 20. Ewing's Sarcoma Family of Tumors / Joseph D. Khoury -- Chapter 21. The Histopathology of Skeletal Metastases / Ping Tang, David G. Hicks --Chapter 22. Interventional Radiologic Techniques and their Contribution to the Management of Bone Tumors / Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk -- Chapter 23. Imaging of Bone Metastases / Nieroshan Rajarubendra, Nathan Lawrentschuk -- Chapter 24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers / Holger Schirrmeister, Coskun Arslandemir -- Chapter 25. Pain Control with Palliative Radiotherapy in Bone Metastases / Alysa Fairchild, Amanda Hird, Edward Chow -- Chapter 26. Mechanisms and Management of Bone Cancer Pain / Ma'ann C. Sabino, Denis R. Clohisy -- Chapter 27. Malignant Skeletal Pain: Mechanisms and Potential Therapeutic Opportunities / Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan, Patrick W. Mantyh -- Chapter 28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches / Julie Rousseau, François Lamoureux, Gaëlle Picarda, François Gouin, Valérie Trichet, Françoise Rédini -- Chapter 29. In vivo Models Used in Studies of Bone Metastases / Ingunn Holen, Michelle A. Lawson -- Chapter 30. Cytokine Gene Therapy in Bone Remodeling / Carl D. Richards, David Smyth -- Chapter 31. Non-surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives / Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, Mario Mercuri -- Chapter 32. Mechanistic Role of RANKL in Cancer-induced Bone Diseases and Development of a Targeted Therapy to Inhibit this Pathway / William C. Dougall -- Chapter 33. Chondrosarcoma of Bone: Diagnosis and Therapy / Arne Streitbuerger, Jendrik Hardes, Georg Gosheger -- Chapter 34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends / Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann -- Chapter 35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer / Alexander H.G.Paterson -- Chapter 36. A Multi-targeted Approach to Treating Bone Metastases / Robert D. Loberg, Kenneth J. Pienta -- Chapter 37. Bone Metastases of Prostatic Cancer: Pathophysiology, Clinical Complications, Actual Treatment and Future Directions / Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold -- Chapter 38. Apoptosis and Drug Resistance in Malignant Bone Tumors / Udo Kontny.
  • 1.New Insights in the Development of Human B Lymphocytes /Bianca Blom --2.The Aging Lymphocyte /Hector F. Valenzuela, Rita B. Effros --3.The Bone Marrow Microenvironment and Its Impact in Acute and Chronic B Cell Malignancies /Jan A. Burger --4.The Expanding Diagnostic Role of Flow Cytometry in Bone Marrow Studies of Patients with Lymphomas and Plasma Cell Disorders /Anna Porwit --5.The Application of Molecular Techniques on Bone Marrow Trephines /Falko Fend, Leticia Quintanilla-Martínez --6.Residual Disease Assessment and Its Role in Monitoring Lymphoid and Plasma Cell Neoplasms /Konnie M. Hebeda --7.Reporting of Bone Marrow Lymphoid Infiltrates /Yi-Hua Chen, LoAnn Peterson --8.Janus-Faced Lymphoid Infiltrates /Dimitra Anagnostou --9.Singularities in Pediatric Bone Marrow Lymphoid Processes /Sophia L. Yohe, Robert W. McKenna --10.Bone Marrow Involvement in Primary Mature B and T Cell Leukemias /Ayoma D. Attygalle --11.A Step Forward in the Diagnosis of B-Cell Lymphomas in the Bone Marrow /Ahmet Dogan, Mine Hekimgil --12.New Insights in Waldenström's Macroglobulinemia /Meletios A. Dimopoulos, Evangelos Terpos --13.Bone Marrow in Hodgkin Lymphoma and Mimickers /Stefano A. Pileri, Elena Sabattini --14.Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas /Philippe Gaulard, Sylvia Hoeller --15.Systemic Mastocytosis Associated with Lymphoproliferative Disorders (SM-AHNMD) /Hans-Peter Horny, Karl Sotlar, Peter Valent.
  • The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
  • Bone metastasis 2005, Springer
    Overview / Sadmeet Singh and Gurmit Singh -- Parathyroid hormone-related peptide and malignancy / David Goltzman -- Vitamin D and vitamin D analogs in cancer / Richard Kremer and Shafaat A. Rabbani -- Role of TGF and IGF in tumor progression and bone metastases / Erin Giles and Gurmit Singh -- Biologic and therapeutic implications of osteomimicry and epithelial/mesenchymal transition in prostate cancer / Wen-Chin Huang, Valerie Odero-Marah, and Leland W.K. Chung -- The roles of immune-cell derived matrix metalloproteinases in tumor growth and metastasis / Kristina A. Szabo and Gurmit Singh -- Contribution of osteopontin to the development of bone metastasis / Alison L. Allan ... [et al.] -- The role of interleukin-11 in osteolytic bone metastasis / Ryan R. Simon ... [et al.] -- Cell adhesion moleculars in tumor metastasis / Sujata Persad ... [et al.] --Antithrombotics in tumor growth and metastasis / Shaker A. Mousa -- Challenges and strategies in the analysis of multiple events in oncology / Pierre P. Major and Richard J. Cook -- Integrins : novel targets for the treatment of bone metastasis / Graham C. Parry ... [et al.] -- Bone metastasis and pathological fractures : bone tissue engineering as a novel therapy / Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singh -- Role of photodynamic therapy for bone metastasis / Shane Burch and Albert J.M. Yee -- Docetaxel for metastatic cancer and its role in combination therapies for advanced prostate cancer / Ellen K. Wasan ... [et al.] -- The use of tetracyclines for bone metastasis / Eric Seidlitz, Zeina Saikali, and Gurmit Singh -- Role of bisphosphonates in skeletal metastases / Arif Hussain and Fred Saad -- Radiation treatment of bone metastases / Edward Chow, Jackson Wu, and Elizabeth Toni Barnes.
  • Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies. The book provides an overview of molecular factors that offer targets and avenues for therapeutic strategies.
  • Bone sarcoma 2013, Springer
    Multidisciplinary approach to the management of sarcomas of bone /Bryan S. Moon --Bone sarcoma imaging /John E. Madewell ... [et al.] --Percutaneous image-guided biopsy for diagnosis of bone sarcomas /Kamran Ahrar --Orthopedic oncologic surgical specimen management and surgical pathology /A. Kevin Raymond and Alexander J. Lazar --Osteosarcoma /Patrick P. Lin and Shreyaskumar Patel --Ewing sarcoma /Patrick P. Lin ... [et al.] --Chondrosarco /Alan W. Yasko, Vinod Ravi, and Ashleigh Guadagnolo --Rare bone sarcomas /Valerae O. Lewis ... [et al.] --Skeletal reconstruction after bone sarcoma resection /Christopher P. Cannon and David W. Chang --Soft tissue reconstruction after bone sarcoma resection /Scott D. Oates --Bone sarcomas in the growing child /Valerae O. Lewis and David W. Chang --Perioperative management of patients with bone sarcomas /Janie Rutledge, Mark S. Pilarczyk, and Alan W. Yasko --Rehabilitation in orthopedic oncology /Benedict Konzen and Christopher P. Cannon --Follow-up evaluation and surveillance after treatment of bone sarcomas /Colleen M. Costelloe and Patrick P. Lin.
  • Bone tumors 2012, Springer
    Introduction to Bone Tumors --How to Evaluate a Bone Lesion --Imaging Modalities --Cartilage Tumors --Osseous Tumors --Fibrous Tumors --Miscellaneous Tumors --Bone Metastases --Bone Tumor Mimickers --Cases.
  • Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
  • Brain cancer 2010, Springer
  • Brain metastases 2007, Springer
  • Brain tumor pathology 2006, Springer
  • Brain tumors 2005, Springer
    Epidemiology of brain tumors / Randa El-Zein, Melissa Bondy, and Margaret Wrensch -- Molecular genetics of tumors of the central nervous system / C. David James -- Molecular pathology of nervous system tumors / Catherine L. Nutt ... [et al.] -- Genetic modeling of glioma formation in mice / Martin Begemann ... [et al.] -- Biology of brain metastasis / Minsoo Kang ... [et al.] -- Analysis of neural precursor cells in the context of origin of brain tumors, their treatment, and repair of treatment-associated damage / Mark Noble and Joerg Dietrich -- Biology of primitive neuroectodermal tumors / John R. Hill, Shoichiro Ohta, and Mark A. Israel -- Molecular and cellular biology of the blood-brain barrier and its characteristics in brain tumors / Helga E. de Vries ... [et al.] -- Immune regulation in the brain : lessons from autoimmunity and implications for brain tumor therapy / Lois A. Lampson -- Genetic pathways in the evolution of gliomas / Hiroko Ohgaki and Paul Kleihues -- DNA damage and repair in the therapeutic response of tumors of the central nervous system / Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman -- Role of urokinase-type plasminogen activator receptor in human glioma invasion / Sanjeeva Mohanam and Jasti S. Rao -- Regulation of the cell cycle and apoptosis in human brain tumors / Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell -- Systemic chemotherapy for metastatic tumors of the central nervous system / Charles A. Conrad and W.K. Alfred Yung -- Radiation biology and therapy of tumors of the central nervous system / Nalin Gupta ... [et al.] -- Advances in the management of cerebral metastases / Fadi Hanbali and Raymond Sawaya -- Immunotherapy of central nervous system tumors: contemporary cancer research / Amy B. Heimberger ... [et al.] -- Targeting drugs to tumors of the central nervous system / Maciej S. Lesniak, James Frazier, and Henry Brem -- Rational design and development of targeted brain tumor therapeutics / Francis Ali-Osman ... [et al.].
  • Brain tumors. 3rd ed. / 2011, ScienceDirect
    Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. You'll also have easy access to the complete contents online, with links to PubMed and a downloadable image library, at www.expertconsult.com. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.
  • Burden of Breast and Gynecological Cancers in Low-Resource Countries -- Breast Cancer: Pathology, Cytology, and Core Needle Biopsy Methods for Diagnosis -- Gynecological Cancers: Pathology and Cytological Methods for Diagnosis of Gynecological Cancers -- Screening and Early Diagnosis of Breast Cancer: Proven Methodology and an Optimized Strategy for Developing Countries -- HPV and Cervical Cancer -- Screening for Cervical Cancer in Low-Resource Countries -- Ovarian Cancer Screening and Early Detection in Low- and Middle-Income Countries -- Endometrial Cancer: Risk Factors and Early Diagnosis in Low-Resource Countries -- Breast and Gynecologic Cancer Prevention in Low-Resource Countries -- Combined Screening for Breast and Gynecological Cancers Using Mobile Clinics: The Barretos Experience (Brazil) -- Cost-Effectiveness of Screening for and Early Diagnosis of Breast and Gynecological Cancers in Low-Income Countries -- Challenges for Breast and Gynecological Cancer Control by Early Detection in Less-Developed Countries -- Funding for Global Healthcare Intervention: Initiatives Aimed at Controlling Cancer in Women in Low-Resource Countries -- Coordinated Training on Early Detection and Diagnosis of Breast Cancer Across Different Levels of Health Workers: An Example from Peru -- Telemedicine in Cancer Control Programs in Developing Countries -- Breast Cancer Screening and Cervical Cancer Prevention in Developing Countries: Strategies for the Future -- Well Woman Clinic Concept: An Integrated Approach for Screening and Early Diagnosis of Breast and Gynecological Cancers in Developing Countries.
  • Breast cancer 2008, Springer
  • Overview -- Common benign conditions of low concern -- Benign conditions associated with a risk for the subsequent development of cancer -- Precursor lesions and noninvasive cancers -- Breast cancer -- Things pathologists must always consider -- Nuances and details of the pathology report.
  • Overview of resistance to systemic therapy in patients with breast cancer / Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez and Gabriel N. Hortobagyi -- Roles of multidrug resistance genes in breast cancer chemoresistance / M. Tien Kuo -- Therapy-induced apoptosis in primary tumors / David J. McConkey -- Cell cycle deregulation in breast cancer: insurmountable chemoresistance or achilles' heel? / Laura Lambert and Khandan Keyomarsi -- p53, BRCA1 and breast cancer chemoresistance / Kimberly A. Scata and Wafik S. El-Deiry -- Integrin-mediated adhesion: tipping the balance between chemosensitivity and chemoresistance / Mary M. Zutter --Insulin-like growth factors and breast cancer therapy / Xianke Zeng and Douglas Yee -- EGF receptor in breast cancer chemoresistance / Robert B. Dickson and T.B. Deb -- Molecular mechanisms of ErbB2-mediated breast cancer chemoresistance / Ming Tan and Dihua Yu -- Estrogen receptors in resistance to hormone therapy / Matthew H. Herynk and Suzanne A.W. Fuqua -- Novel approaches for chemosensitization of breast cancer cells: the E1A story / Yong Liao, Dihua Yu and Mien-Chie Hung.
  • Global burden of breast cancer / Jacques Ferlay ... [et al.] -- Breast cancer biology and clinical characteristics / Amanda I. Phipps and Christopher I. Li -- In situ breast cancer / Brian L. Sprague and Amy Trentham-Dietz -- Endogenous hormones / Amanda I. Phipps and Christopher I. Li -- Exogenous hormones / Christopher I. Li and Elisabeth F. Beaber -- Reproductive factors / Mats Lambe -- Physical activity and anthropometric factors / Katherine D. Henderson, Jennifer Prescott, and Leslie Bernstein -- Diet and nutrition / Martin Lajous and Shumin M. Zhang -- Environmental and occupational exposures / Amanda I. Phipps ... [et al.] -- Shift work and circadian disruption / Scott Davis and Dana K. Mirick -- Non-hormonal medications and chronic diseases / Patricia F. Coogan -- Male breast cancer / Ian S. Fentiman -- Inherited predisposition: familial aggregation and high risk genes / Kathleen E. Malone and Kerryn W. Reding -- Common genetic susceptibility loci / Mikkel Z. Oestergaard and Paul Pharoah -- Mammographic density as a potential surrogate marker for breast cancer / Norman F. Boyd, Lisa J. Martin, and Salomon Minkin -- Breast cancer screening / Karla Kerlikowske -- Principles of breast cancer therapy / Allison W. Kurian and Robert W. Carlson -- Breast cancer outcomes / Graham A. Colditz and Courtney Beers.
  • Burden of breast cancer in developing and developed countries -- Genetics of breast cancer in women of African Descent: an overview -- Biology of breast cancer: molecular and pathologic features of ductal neoplasia of the breast: racial considerations -- Screening and early detection of breast cancer in women in Africa and the Middle East -- Breast cancer at diagnosis in women of Africa and the Middle East -- Breast cancer aggressiveness in women of African descent -- Radiotherapy of breast cancer -- Adjuvant therapy of breast cancer -- Endocrine therapy of breast cancer -- Palliative care for breast cancer in the African-American population -- Outcome of African American women with breast cancer in cooperative group clinical trials -- Traditional medicine in breast cancer management with a focus on the Chinese integrative approach -- Impact of culture, education and socio-economic status -- Barriers to successful management of breast cancer.
  • This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed --source other than Library of Congress.
  • Breast cancer research protocols 2005, Springer Protocols
    Breast tissue banking: collection, handling, storage, and release of tissue for breast cancer research / Linda Snell and Peter H. Watson -- Frozen biopsy collection and storage: frozen biopsy samples / Russell Leek -- Serial biopsies/fine-needle aspirates and their assessment / Irene Boeddinghaus and Stephen R.D. Johnson -- Breast tissue microarrays / Robert J. Springall and Cheryl E. Gillett -- Preparation of tumor homogenates for subsequent preparation of cytosols, membrane fractions, RNA, and DNA / Naomi Robertson and Russell Leek -- Isolation of RNA from tumor samples: single-step guanidinium acid-phenol method / Naomi Robertson and Russell Leek -- Isolation of DNA from tumor samples / Naomi Robertson and Russell Leek -- Laser-assisted microdissection and isolation of DNA and RNA / Ulrich Lehmann and Hans Kreipe --Fluorescence in situ hybridization and comparative genomic hybridization / Patricia Gorman and Rebecca Roylance -- Fluorescence in situ hybridization assessment of c-myc gene amplification in breast tumor tissues / Jan K. Blancato, Mary Steele Williams, and Robert B. Dickson -- Detection of HER2 gene amplification by fluorescence in situ hybridization in breast cancer / John M.S. Bartlett, and Amanda Forsyth -- In situ hybridization combined with immunohistochemistry to localize gene expression / Rosemary Jeffery, Toby Hunt, and Richard Poulsom -- Quantitation of RNA by ribonuclease protection assay / John W. Moore -- Identification of steroid hormone-regulated genes in breast cancer / Bruce R. Westley and Felicity E.B. May -- Sequencing of the tumor suppressor gene TP 53 / Barbro Linderholm, Torbjörn Norberg, and Jonas Bergh -- Expression profiling using cDNA microarrays / Chris Jones ... [et al.] -- Gene expression analysis using filter cDNA microarrays / Peter Simpson ... [et al.] --Immunohistochemistry / Cheryl E. Gillett -- Detection of aberrant glycosylation in breast cancer using lectin histochemistry / Tracey M. Carter and Susan A. Brooks -- SDS-PAGE and western blotting to detect proteins and glycoproteins of interest in breast cancer research / Chloe Osborne and Susan A. Brooks -- Breast cancer proteomics using two-dimensional electrophoresis: studying the breast cancer proteome / Miriam V. Dwek and Sarah L. Rawlings -- Procedures for the quantitative protein determination of urokinase and its inhibitor PAI-1 in human breast cancer tissue extracts using ELISA / Manfred Schmitt ... [et al.] --Methods to analyze the effects of the urokinase system on cancer cell adhesion, proliferation, migration, and signal transduction events / Ute Reuning ... [et al.] -- Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage / Kum Kum Khanna, Magtouf Gatei, and Gordon Tribbick -- Models of hormone resistance in vitro and in vivo / Jennifer MacGregor Schafer and V. Craig Jordan -- Generation of genetically modified embryonic stem cells for the development of knockout mouse animal model systems / Stephen D. Robinson, Stephen Wilson, and Kairbaan M. Hodivala-Dilke -- In vivo xenograft models of breast cancer metastatsis / Ursula Valentiner, Susan A. Brooks, and Udo Schumacher -- Neoadjuvant endocrine therapy models / Juliette Murray, William R. Miller, and J. Michael Dixon -- Primary mouse endothelial cell culture for assays of angiogenesis / Louise E. Reynolds and Kairbaan M. Hodivala-Dilke.Traditional and established indicators of prognosis and treatment success / Derek E. Roskell and Ian D. Buley -- Sentinel lymph node biopsy in breast cancer / Celia Chao and Kelly M. McMasters -- Pathological evaluation of axillary sentinel lymph nodes in breast cancer / Michael Z. Gilcrease and Aysegul Sahin -- Measurement of estrogen receptor status by immunocytochemistry in paraffin wax sections / Bharat Jasani ... [et al.] -- Markers of apoptosis / Falzul H. Sarkar and Yiwei Li -- Quantitative angiogenesis in breast cancer / Stephen B. Fox --
  • Part I. Prevention -- Risk Factors / Polly A. Newcomb and Karen J. Wernli -- Lifestyle Factors and Risk of Breast Cancer: A Review of Randomized Trial Findings / Garnet L. Anderson -- Breast Cancer Chemoprevention / Mary B. Daly -- Surgical Management of Inherited Susceptibility to Breast Cancer / Francis Freisinger and Susan M. Domchek -- Part II. Early Detection -- Clinical Breast Examination and Breast Self-Examination / William H. Goodson -- Mammography / Barbara C. Cavanaugh and Sorcha McNally -- Current Status and Future Prospects in Breast Carcinoma of Positron Emission Tomography / Sandip Basu, Joshua I. Rosenbaum and Abass Alavi -- Breast MRI / Barbara C. Cavanaugh and Sorcha McNally -- Genetic and Molecular Approaches to Imaging Breast Cancer / Eric Wickstrom and Mathew L. Thakur -- Intraductal Approaches: Nipple Aspirate Fluid to Assist in Breast Cancer Detection / Edward R. Sauter -- Intraductal Approaches: Mammary Ductoscopy and Ductal Lavage to Assist in the Diagnosis of Breast Cancer / William C. Dooley -- Blood Markers / Mark W. Duncan -- Circulating Tumor Cells in Breast Cancer / Michail Ignatiadis and Dimitris Mavroudis.
  • The volume raises attention to the need of a completely new approach to breast cancer based on the knowledge collected on early breast cancer in the past two decades. The chapters are contributed by experts of all the fields participating in the clinical research and care of breast cancer. The practical importance of such a book is underlined by the increasing number of breast cancer cases, and also the increasing proportion of early stage-cases. The ultimate goal of the book is to point to the heterogeneous nature of the disease which is more striking and has more importance in care at the very early stages than at the more advanced stages. The book recommends the utilisation of all the information provided by multimodality imaging and special pathological methods, a new classification system and therapeutic guidelines since early breast cancers should not be treated based on experience obtained with palpable tumors. No similar book has been yet released to the market. The book is written for all the members of the team participating in the diagnosis and treatment of breast cancer (radiologists, pathologists, surgeons, clinical and radiation oncologists), but may be useful for medical students and residents too. The chapters are illustrated with didactic pictures, and special emphasis is given to provide a peep into the practice of the special procedures for the careful examination and individualized therapy of each case.
  • The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. "Breast Cancer: A Lobar Disease," presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts.
  • Breast Cancer: A New Era in Management provides a compendium of succinct analysis of the many facets involved in the present day management of the breast cancer patient. The text provides the clinician or student with basic foundational knowledge in the rapidly expanding areas of expertise that are required for both the diagnosis and treatment of the breast cancer patient. Each topic, whether diagnostic or therapeutic, is presented in a straightforward fashion incorporating as part of each topic a description of the historical clinical landmarks leading to the present day, their present day position in the care of the breast patient, and finally, an assessment of possible future application and adaptation in clinical practice. Emphasis is placed on clear and concise explanations of each topic presented in stepwise fashion from fundamental elements to the more complex. Breast Cancer: A New Era in Management will act as a ready reference for the practicing surgeon and students seeking practical information on a particular clinical topic or scenario.
  • Breast cancer. 2nd ed. 2008, Springer
  • Breast carcinoma 2008, Springer
  • Breast anatomy and basic histology, physiology, and pathology -- A pathologist's overview of the pathology of breast disease / Joseph Rabban -- Epidemiology, etiology, risk factors, and survival from breast cancer -- Screening for breast cancer -- Radiation risk -- Staging breast cancer -- Ductal carcinoma in situ and early-stage breast cancer: detection, diagnosis, and prognostic indicators -- Mammography: equipment and basic physics -- Quality assurance and quality control / Debra Deibel -- Mammographic positioning -- A systematic approach to breast imaging -- Mammography and the normal breast -- Interpreting the mammogram -- Benign lesions -- Probably benign findings appropriately managed with short-interval follow-up --Suspicious lesions and lesions with a high probability of malignancy -- Breast ultrasound -- The altered breast: pregnancy, lactation, abscess, post biopsy changes, mastectomy, radiation, and implants -- The male breast -- Magnetic resonance imaging of the breast / Carol A. Hulka and Daniel B. Kopans -- Evaluating women with lumps, thickening, discharge or pain: imaging women with signs or symptoms that might indicate breast cancer -- Image sequencing: problems and solutions in breast evaluation -- Histological, pathological and imaging correlation -- Interventional procedures in the breast -- The breast imaging report: data management and the breast imaging audit -- The medical-legal problem and breast imaging -- Digital mammography -- Digital breast tomosynthesis -- Cytopathology.
  • Breast MRI 2005, Springer
  • Breast MRI 2008, Springer
  • Pt. 1. Fundamentals -- pt. 2. Biologic principles -- pt. 3. Initial evaluation of the patient -- pt. 4. Common presenting complaints and concerns -- pt. 5. Diagnostic techniques -- pt. 6. Breast cancer overview -- pt. 7. Breast surgery : management of the primary tumor -- pt. 8. Breast surgery : sentinel node biopsy and axillary dissection -- pt. 9. Breast surgery : special issues -- pt. 10. Cytology and pathology -- pt. 11. Systemic therapy for breast cancer -- pt. 12. Radiation therapy of the breast -- pt. 13. The breast cancer survivor.
  • Breast ultrasound 2013, Springer
    Diagnosis of breast cancer: modern aspects -- Technique of breast ultrasound -- Ultrasound of the normal breast -- Ultrasound diagnosis of breast cancer -- Classification of breast masses -- Ultrasound features of different types of breast cancer -- Differential diagnosis of breast diseases -- Age-related changes in breast structure: breast ultrasound in children and adolescents -- Breast pathology in men -- Ultrasound examination of regional lymph nodes -- Ultrasound examination after breast surgery -- Recurrent breast cancer.
  • Written by internationally acclaimed specialists, Breast, Endocrine and Surgical Oncology provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated throughout by photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Breast, Endocrine and Surgical Oncology provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.
  • Burkitt's lymphoma 2013, Springer
    This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt's lymphoma.
  • Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai -- Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart -- Inhibitors of topoisomerase I function / Sidney M. Hecht -- Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.] -- Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti -- Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.] -- Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin -- Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.] -- Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto -- Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen -- Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory -- Clinical experience with topotecan / Aimee K. Bence and Val R. Adams -- The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.] -- Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky -- Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman -- Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.] -- Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.
  • Cancer 2006, Springer
  • Cancer and aging 2013, Karger
    Chronic mechanistic target of rapamycin inhibition : preventing cancer to delay aging, or vice versa? / Sharp, Z.D.; Curiel, T.J.; Livi, C. -- Senescent cells and their secretory phenotype as targets for cancer therapy / Velarde, M.C.; Demaria, M.; Campisi, J. -- Cancer vaccination at older age / Gravekamp, C. -- Immunology of aging and cancer development / Fulop, T. ... [et al.] -- Metabolic syndrome and cancer : from bedside to bench and back / Extermann, M. -- Frailty : a common pathway in aging and cancer / Balducci, L. -- Targeting age-related changes in the biology of acute myeloid leukemia : is the patient seeing the progress? / Vey, N. -- Comprehensive geriatric assessment in oncology / Mohile, S.G.; Magnuson, A. -- Pharmacology of aging and cancer : how useful are pharmacokinetic tests? / Lichtman, S.M. -- Surgery in older cancer patients : recent results and new techniques : worth the investment? / Van Leeuwen, B.L.; Huisman, M.G.; Audisio, R.A. -- Organizing the geriatrician/oncologist partnership : one size fits all? practical solutions / Holmes, H.M.; Albrand, G. -- Geriatric oncology nursing : beyond standard care / Overcash, J. -- Exercise for older cancer patients : feasible and helpful? / Klepin, H.D.; Mohile, S.G. ; Mihalko, S. -- Aging and cancer : addressing a nation's challenge / Brochot, J.-M.; Le Quellec-Nathan, M.; Buzyn, A.
  • 1. Obesity and Cancer Epidemiology -- 2. Obesity and Cancer: Epidemiology in Racial/Ethnic Minorities -- 3. Obesity and Cancer in Asia -- 4. Genetic Epidemiology of Obesity and Cancer -- 5. Obesity and Cancer: Overview of Mechanisms -- 6. Caloric Restriction and Cancer -- 7. Physical Activity and Cancer -- 8. Energy Balance, Cancer Prognosis, and Survivorship -- 9. Behavior, Energy Balance, and Cancer: An Overview -- 10. Geographic and Contextual Effects on Energy Balance-Related Behaviors and Cancer.
  • Cancer and IgE 2010, Springer
  • Cancer and pregnancy 2008, Springer
  • Cancer and sexual health 2011, Springer
    Functional Anatomy of the Male Sex Organs -- Functional Anatomy of the Female Sex Organs -- Physiology of Libido -- Physiology of Orgasm -- Physiology of Female Genital Sexual Arousal -- Physiology of Erection -- Physiology of Ejaculation -- Classifying Female Sexual Dysfunction -- Hypoactive Sexual Desire Disorder -- Disorders of Female Sexual Arousal -- Disorders of Female Orgasm -- Sexual Pain Disorders -- Erectile Dysfunction: Prevalence and Pathophysiology -- Androgen Deficiency -- Peyronie?s Disease -- Disorders of Ejaculation and Male Orgasm -- Priapism -- The Sexual Health Interview: Male -- The Sexual Health Interview: Female -- Communication About Sexuality and Cancer -- Validated Questionnaires in Female Sexual Function Assessment -- Validated Questionnaires in Male Sexual Function Assessment -- Evaluation of the Female with Sexual Dysfunction -- Evaluation of Male Sexual Dysfunction -- The Impact of Cancer on the Partner?s Sexuality -- Gay and Lesbian Patients with Cancer -- The Impact of a Cancer Diagnosis on Sexual Health -- Breast Cancer -- Gynecological Cancers -- Pelvic Surgery for Urological Cancers -- Pelvic Radiation in Men -- Pelvic Radiation in Women -- Impact of Chemotherapy and Hormone Therapy on Female Sexual Health -- Impact of Androgen Deprivation Therapy on Men?s Sexual Health -- Colorectal Cancer -- Stem Cell Transplant --Sexual Health in the Terminally Ill -- Survivorship: An Overview -- Nutriceuticals in Sexual Health -- Medical Treatments for Sexual Problems in Women -- Surgical Treatments for Sexual Problems in Women -- Sex Therapy in Female Sexual Dysfunction -- Erectile Dysfunction: Pharmacological Therapy -- Erectile Dysfunction: Devices -- The Management of Premature Ejaculation -- Testosterone Therapy in the Male Cancer Patient -- Sex Therapy in Male Sexual Dysfunction -- Restoring Intimacy in Relationships Affected by Cancer -- Dating and Disclosure for Cancer Survivors.
  • Peyton Rous: A Centennial Tribute to the Founding Father of Cancer Virology --Viruses and Cancer: A Historical Perspective - HBV and Prevention of a Cancer --Virus-Mediated Cell Proliferation --Viral-Encoded Genes and Cancer --Oncogenic Viruses and Cancer Transmission --DNA Viruses and Cancer: Taking a Broader Look --Herpesviruses and Cancer --Lymphocryptoviruses: EBV and Its Role in Human Cancer --Nonhuman Primate Gamma-herpesviruses and Their Role in Cancer --Rhadinoviruses: KSHV and Associated Malignancies --Retroperitoneal Fibromatosis Herpesvirus and Kaposi's Sarcoma-Like Tumors in Macaques --Murine Gammaherpesvirus-Associated Tumorigenesis --Marek's Disease Virus-Induced T-Cell Lymphomas --Polyomaviruses and Cancer --Polyomavirus SV40: Model Infectious Agent of Cancer --BK Polyomavirus and Transformation --Polyomavirus JC and Human Cancer: Possible Role of Stem Cells in Pathogenesis --Merkel Cell Polyomavirus --Human Papillomaviruses and Cancer --Tumorigenesis by Adenovirus Type 12 E1A --Overview of Hepatitis Viruses and Cancer --Hepadnaviruses and Hepatocellular Carcinoma --Hepatitis C Virus and Hepatocellular Carcinoma --Human and Animal Retroviruses: HIV-1 Infection Is a Risk Factor for Malignancy --HTLV-1 and Oncogenesis --Human T-Cell Leukemia Virus Type 2 (HTLV-2) Biology and Pathogenesis --Mechanisms of Oncogenesis by Avian and Murine Retroviruses --Rous Sarcoma Virus: Contributions of a Chicken Virus to Tumor Biology, Human Cancer Therapeutics, and Retrovirology --Mouse Mammary Tumor Virus and Cancer --Jaagsiekte Sheep Retrovirus and Lung Cancer --Small RNAs and Their Role in Herpesvirus-Mediated Cancers --Viral Malignancies in HIV-Associated Immune Deficiency.
  • Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.
  • Cancer cachexia 2013, Future Med
    Cancer cachexia / Josep M. Argilés & Sílvia Busquets -- Prevalence and clinical features of cancer cachexia / Neil Johns, Richard J.E. Skipworth, Kenneth C.H. Fearon & James A. Ross -- Pathogenesis of cancer cachexia / Fabio Penna, Francesco M. Baccino & Paola Costelli -- Current medications for cancer cachexia / Clelia Madeddu, Antonio Macciò, Maria Chiara Cau, Roberto Serpe & Giovanni Mantovani -- Latest developments in cachexia drug discovery : clinical trials / Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler & Sílvia Busquets -- Comorbidities and prognosis / Alessandro Laviano, Gianluca Di Lazzaro Giraldi & Serena Rianda -- Index.
  • Cancer cell culture 2004, Springer Protocols
  • Cancer cell signaling 2002, Springer Protocols
  • Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past decade, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.
  • Clinical strategies for cancer treatment: the role of drugs -- Target identification and drug discovery -- Clinical drug development and marketing approval -- Principles of pharmacokinetics -- Delivering anticancer drugs to brain tumors -- Pharmacogenetics -- Physical barriers to drug delivery -- Antifolates -- 5-fluoropyrimidines -- Cytidine analogues -- Purine antimetabolites -- Hydroxyurea -- Antimitotic drugs -- Alkylating agents -- Platinum analogues -- Bleomycin and other antitumor antibiotics -- Topoisomerase I-targeting drugs -- Topoisomerase II inhibitors: anthracyclines -- Topoisomerase II inhibitors: the epipodophyllotoxins -- Asparaginase -- Proteasome inhibitors -- Histone deacetylase inhibitors in oncology -- Differentiating agents -- Arsenic trioxide -- Antibodies -- Inhibitors of tumor angiogenesis -- Epidermal growth factor receptor inhibitors -- HER2 inhibitors -- Molecular targeted drugs -- Signaling inhibitors: IGFR, PI3K pathway, embryonic signaling inhibitors, and mitotic kinase inhibitors -- Cytokine therapy for cancer -- Cancer vaccines -- Adoptive cellular therapies -- Thalidomide and its analogs in the treatment of hematologic malignancies, including multiple myeloma, and solid tumors -- Hormonal therapy of breast cancer -- Hormone therapy for prostate cancer -- Drug therapy of pain in cancer patients -- Hematopoietic growth factors -- Antinausea medications -- Bisphosphonates and other bone-targeted therapies -- Intravenous access and catheter management -- Late effects of cancer chemotherapy -- Infertility after cancer chemotherapy.
  • A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.
  • Cancer clinical trials 2007, Springer
    Historical perspective and evolving concerns for human research / Bernard Lo and Nesrin Garan -- Cancer trials and the Institutional Review Board (IRB) / Scott Kurtzman and Zita Lazzarini -- NCI's cancer therapy evaluation program: a commitment to treatment trials / Jeffrey S. Abrams, Anthony Murgo and Michaele C. Christian -- Practical guide for cancer clinical investigators / Steven Hirschfeld -- The role of cooperative groups in cancer clinical trials / Ann M. Mauer, Elizabeth S. Rich and Richard L. Schilsky -- The advocate role in clinical study development and partnering with patient advocates in your local institution / Barbara Parker -- The National Breast Cancer Coalition: setting the standard for advocate collaboration in clinical trials / Fran Visco -- The role of the principal investigator in cancer clinical trials / Stanley P.L. Leong -- The audit process and how to ensure a successful audit / Y. Nancy You, Lisa Jacobs, Elizabeth Martinez and David M. Ota -- The privacy rule (HIPAA) as it relates to clinical research / John M. Harrelson and John M. Falletta -- The Commission on Cancer, American College of Surgeons' response to HIPAA / E. Greer Gay -- Ethical and legal issues in the conduct of cancer clinical trials / Gerianne J. Sands and Peggy A. Means -- The role of the Office of Research Integrity in cancer clinical trials / Peter Abbrecht, Nancy Davidian, Samuel Merrill and Alan R. Price -- Strategies for the administration of a clinical trial infrastructure: lessons from a comprehensive cancer center / Leonard A. Zwelling and Carleen A Brunelli -- The clinical research process: building a system in harmony with its users / Greg Koski -- Cancer research and clinical trial in action: an important exercise before you embark on your study / Stanley P.L. Leong, Larry Carbone and Scott Kurtzman.
  • Cancer drug resistance 2006, Springer
  • Cancer epidemiology v. 1-2, 2009, Springer Protocols
    v. 2, 2009 Springer Protocols
    v. 1. Host susceptibility factors -- v. 2. Modifiable factors.
  • Cancer epigenetics 2009, CRCnetBASE
    The role of epigenetics in cancer / Trygve O. Tollefsbol -- DNA hypomethylation in cancer / Peter L. Molloy -- DNA hypermethylation in oncogenesis / J. Tyson DeAngelis ... [et al.] -- Imprinting alterations in tumorigenesis / Jeremiah Bernier-Latmani and Phillip Shaw -- Proteins that modulate DNA methylation aberrations in cancer / Sabrina L. Walthall ... [et al.] -- The role of DNA methylation in cancer progression / Sang-Woon Choi and Simonetta Friso -- Alterations in histone acetylation in tumorigenesis / Sabita N. Saldanha and Trygve O. Tollefsbol -- Histone methylation and the initiation of cancer / Shi Huang -- The role of sirtuins in aging and tumorigenesis / Xiaohong Zhang ... [et al.] -- Proteins that alter histone modifications in cancer / Ada Ao and Jianrong Lu -- Dietary and environmental influences on histone modifications in cancer / Sabita N. Saldanha ... [et al.] -- Noncoding RNAs in cancer / Maciej Szymanski and Jan Barciszewski -- Cancer-linked DNA hyper- and hypomethylation: chromosome positional effects / Melanie Ehrlich -- Chromatin remodeling and cancer / Sari Pennings and Richard R. Meehan --Poly-ADP-ribosylation in cancer / Rajeshwar N. Sharan -- Polycomb group proteins in tumorigenesis / Hanneke E.C. Niessen and Jan Willem Voncken -- Cancer and aging: the epigenetic connection / Craig A. Cooney -- DNA methylation in tumor diagnosis / Kavitha Ramachandran, Edna Gordian, and Rakesh Singal -- DNA methylation profiles as prognostic markers for cancer / Sam Thiagalingam and Panagiotis Papageorgis -- Diagnosing cancer using histone modification analysis / Mukesh Verma and Deepak Kumar -- Histone modifications in cancer biology and prognosis / Matthew A. McBrian, David B. Seligson, and Siavash K. Kurdistani -- Histone deacetylase inhibitors in cancer therapy / Aaron M. Sargeant ... [et al.] -- Methylation changes in neoplasia: diagnostic and therapeutic implications / Eleftheria Hatzimichael, Justin Stebbing, and Tim Crook -- Clinical trials and approved drugs for epigenetic cancer therapy / Debby M.E.I. Hellebrekers and Manon van Engeland -- Future directions in epigenetic cancer research / Jacob Peedicayil.
  • Cancer gene therapy 2005, Springer
    Cancer gene therapy : historical perspective / Malcolm K. Brenner -- The genetic basis of cancer / Akseli Hemminki and Kari Hemminki -- Tumor suppressor gene replacement for cancer / Jack A. Roth and Susan F. Grammer -- Antisense technology / Ruiwen Zhang and Hui Wang -- Cancer therapeutic applications of ribozymes and RNAi / Lisa Scherer and John J. Rossi -- Fusogeneic membrane glycoproteins for cancer gene therapy : a better class of killer / Andrew Bateman ... [et al.] -- Suicide gene therapy / Caroline J. Springer and Ion Niculescu-Duvaz -- Molecular chemotherapy approaches / Daniel H. Palmer and David J. Kerr -- Genetic immunotherapy approaches / Denise R. Shaw and Albert F. LoBuglio -- Immunotherapy of cancer by dendritic cell-targeted : gene transfer / Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper -- Dendritic cells / Weiping Zou, Shuang Wei and Tyler J. Curiel --Polynucleotide immunization for cancer therapy / Theresa V. Strong -- Development of oncolytic replication-competent herpes simplex virus vectors: the G207 paradigm / Tomoki Todo and Samuel D. Rabkin -- Development of oncolytic adenoviruses : from the lab bench to the bedside / John A. Howe, Robert Ralston, and Murali Ramachandra -- Conditionally replicating adenoviruses for cancer treatment / Ramon Alemany -- Reovirus as an oncolytic agent / Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee -- Antiangiogenic gene therapy of cancer / Steve Gyorffy ... [et al.] -- Proapoptotic strategy in cancer gene therapy / David H. Holman ... [et al.] -- Antimetastasis / Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung -- Antimetastatic gene therapy : prostate cancer theory to therapy / Thomas A. Gardner ... [et al.] --Drug-resistance gene transfer as an antitumor strategy / Colin L. Sweeney and R. Scott McIvor -- Chemosensitization / Per Eystein Lønning -- Radiosensitization by gene therapy / Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum -- Nonviral vector systems for cancer gene therapy / Greg F. Walker and Ernst Wagner -- Viral vectors for cancer gene therapy / Joanne T. Douglas and David T. Curiel -- Bacterial systems for tumor-specific gene therapy / J. Martin Brown ... [et al.] -- Molecular imaging of cancer gene therapy / Harvey R. Herschman -- Cancer-related gene therapy clinical trials / Robert J. Korst and Ronald G. Crystal -- Regulatory aspects in the development of gene therapies / Rosemarie Aurigemma ... [et al.].
  • Cancer genetics 2010, Springer
  • Cancer genomics 2014, ScienceDirect
    Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.
  • Cancer genomics and proteomics 2007, Springer Protocols
    Reciprocal subtraction differential RNA display (RSDD) : an efficient technology for cloning differentially expressed genes / Devanand Sarkar, Dong-chul Kang, and Paul B. Fisher -- Cloning differentially expressed genes using rapid subtraction hybridization (RaSH) / Habib Boukerche ... [et al.] -- The application of differential display as a gene profiling tool / Ken Chien-Neng Chang ... [et al.] -- Serial analysis of gene expression (SAGE) / Fred van Ruissen and Frank Baas -- Gene expression profile analysis of tumors / Katia Basso and Riccardo Dalla-Favera -- cDNA microarray and bioinformatic analysis of nuclear factor [kappa]B related genes in squamous cell carcinoma / Zhong Chen ... [et al.] -- Gene profiling uncovers retinoid target genes / Yan Ma ... [et al.] -- Complete open reading frame (C-ORF) technique : rapid and efficient method for obtaining complete protein coding sequences / Dong-chul Kang and Paul B. Fisher -- Chromatin immunoprecipitation assays : molecular analysis of chromatin modification and gene regulation / Piyali Dasgupta and Srikumar P. Chellappan -- Manipulating genes and gene copy number by bacterial artificial chromosome transfection / Stephanie F. Phelps, Sharon Illenye, and Nicholas H. Heintz -- Molecular cytogenetic applications in analysis of the cancer genome / Pulivarthi H. Rao, Subhadra V. Nandula, and Vundavalli V. Murty -- Monitoring methylation and gene expression in cancer / Hetty Carraway and James Herman -- The use of phage display peptide libraries for basic and translational research / Renee Brissette and Neil I. Goldstein -- Yeast and mammalian two-hybrid systems for studying protein-protein interactions / Shu-ichi Matsuzawa and John C. Reed -- Ribonomic and short hairpin RNA gene silencing methods to explore functional gene programs associated with tumor growth arrest / Timothy E. Baroni ... [et al.] -- Surface-epitope masking (SEM) : an immunological subtraction approach for developing monoclonal antibodies targeting surface-expressed molecules / Neil I. Goldstein and Paul B. Fisher -- Approaches for monitoring signal transduction changes in normal and cancer cells / Paul Dent ... [et al.] -- PKR in innate immunity, cancer, and viral oncolysis / Siddharth Balachandran and Glen N. Barber -- Analysis of transformation and tumorigenicity using mouse embryonic fibroblast cells / Hong Sun and Reshma Taneja -- Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells / Hong Sun, Neriman Tuba Gulbagci, and Reshma Taneja -- Reverse phase protein microarrays for monitoring biological responses / Virginia Espina ... [et al.] -- Protein crystallization / Champion Deivanayagam, William J. Cook, and Mark R. Walter.
  • This is the second edition of a practice-oriented, well-illustrated manual on the microscopic grading of tumors. After an introduction on the history and basic tenets of tumor grading, subsequent chapters focus on specific organ systems. In each case, the most widely used system for grading common tumors is presented and discussed. Throughout, careful attention is paid to the principles of microscopic tumor grading, ancillary methods to improve grading, and the latest techniques used in evaluating tumors and formulating prognosis.
  • Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
  • Cancer immunotherapy 2013, Springer
    This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Introduction / W. Archie Bleyer ... [et al.] -- History of adolescent oncology / Cameron K. Tebbi -- Epidemiology and etiology of cancer in adolescents and young adults / Jillian M. Birch and W. Archie Bleyer -- Access to care before and during therapy / Karen H. Albritton and Tim Eden -- Older adolescents and young adults with cancer, and clinical trials: lack of participation and progress in North America / W. Archie Bleyer, Troy Budd, and Michael Montello -- Acute lymphoblastic leukemia / James Nachman, Giuseppe Masera, and W. Archie Bleyer -- Acute myelogenous leukemia / Ursula Creutzig and William G. Woods -- Hodgkin lymphoma / Tanya M. Trippett ... [et al.] -- Non-hodgkin lymphoma / Catherine Patte, W. Archie Bleyer, and Mitchell S. Cairo -- Central nervous system tumors in adolescents and young adults / David A. Walker ... [et al.] -- Soft-tissue sarcomas / Karen H. Albritton, Andrea Ferrari, and Michela Casanova -- Bone sarcomas / Michael S. Isakoff ... [et al.] -- Malignancies of the ovary / Jubilee Brown, Thomas Olson, and Susan Sencer -- Testicuar tumors / John W. Cullen and Robert Fallon -- Non-germ-cell genitourinary tract tumors / Michael Leahy and W. Archie Bleyer -- Thyroid cancer / Steven G. Waguespack and Samuel A. Wells --Malignant melanoma / Cynthia E. Herzog, W. Archie Bleyer, and Alberto S. Pappo -- Breast cancer / Marianne Phillips, Banu Arun, and W. Archie Bleyer -- Liver tumors / Marcio H. Malogolowkin, Arthur Zimmermann, and Jack Plaschkes -- Colorectal cancer / Wayne L. Furman, D. Ashley Hill, and Michael LaQuaglia -- Models of care and specialized units / Ian Lewis and Sue Morgan -- Drug compliance by adolescent and young adult cancer patients: challenges for the physician / Benjamin Gesundheit ... [et al.] -- Psychological support for adolescents and young adults / Christine Eiser and Aura Kuperberg -- Psychosocial support / Brad J. Zebrack, Mark A. Chesler, and Anthony Penn -- Health-related quality of life / Ernest R. Katz ... [et al.] -- Rehabilitation and exercise / Marilyn J. Wright -- Adolescent and young adult cancer survivors: late effects of treatment / Smita Bhatia ... [et al.] -- Ethical issues for the adolescent and young adult cancer patient: assent and end-of-life care / Susan Shurin and Eric Kodish -- Access to care after therapy / Karen E. Kinahan ... [et al.] -- Future health of survivors of adolescent and young adult cancer / Melissa M. Hudson and Kevin C. Oeffinger -- Information and resources for young adults and adolescents with cancer / David R. Freyer and Leonard J. Mattano -- Making ends meet: financial issues from the perspectives of patients and their healthcare team / David R. Freyer and Ronald D. Barr -- Challenges and opportunities - the way ahead / W. Archie Bleyer ... [et al.].
  • Cancer management in man 2011, Springer
    This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer management. The chemotherapy section of the book is updated to include the newest drugs as well as those currently in development. Organized by drug class, this section provides the latest information on most drugs, including their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance.
  • Print Material
    Cancer biology -- Cancer immunology -- Cancer etiology -- Cancer epidemiology, prevention, and screening -- Clinical trials and outcomes assessment -- Cancer pathology -- Imaging -- Surgical oncology -- Radiation oncology -- Medical oncology -- Chemotherapy -- Chemotherapeutic agents -- Biotherapeutics -- Endocrine therapy -- Gene therapy -- Bone marrow transplantation -- Psycho-oncology -- Oncology nursing -- Cancer rehabilitation medicine -- Multidisciplinary management -- Pain and palliation -- Societal oncology -- Central nervous system -- The Eye -- Endocrine glands -- Head and neck -- The Thorax -- Gastrointestinal tract -- Genitourinary tract -- Female reproductive organs -- The Breast -- The Skin -- Bone and soft tissue -- Hematopoietic system -- Neoplasms in AIDS --- Unknown primary site -- Pediatric oncology -- Complications of cancer and their treatment -- Infection in the cancer patient -- Oncologic emergencies -- Oncology and informatics.
  • Cancer nanotechnology 2013, CRCnetBASE
    Basic principles of radiation therapy of cancers / Laurence Court and Radhe Mohan -- Biological principles of radiosensitization / Vikas Bhardwaj ... [et al.] -- Principles and applications of hyperthermia combined with radiation / Mark Hurwitz -- Synthesis and surface modification of nanomaterials for tumor targeting / Glenn Goodrich -- Safety concerns for nanomaterials in nanomedicinal applications / Qingxin Mu ... [et al.] -- Imaging with nanoparticles / Amit Joshi -- Optical microscopy of plasmonic nanoparticles / Varun P. Pattani and James Tunnell -- X-ray fluorescence computed tomography imaging of nanoparticles / Bernard L. Jones and Sang Hyun Cho -- Gold nanoparticle-mediated radiosensitization / Devika B. Chithrani -- Quantification of gold nanoparticle-mediated radiation dose enhancement / Sang Hyun Cho and Bernard L. Jones -- Semiconductor nanomaterials for radiotherapy / Ke Sheng -- Radioactive gold nanoparticle for tumor therapy / Raghuraman Kannan, Kattesh V. Katti, and Cathy Cutler -- Nanoparticles for the selective radioprotection of normal tissues / Jacob M. Berlin and Kathy A. Mason -- Gold nanoparticle-mediated hyperthermia in cancer therapy / Dev K. Chatterjee and Sunil Krishnan -- Magnetic resonance thermometry imaging for gold nanoparticle-mediated thermal therapy / R. Jason Stafford and John D. Hazle -- Modeling of plasmonic heat generation from gold nanoparticles / Francisco Reynoso and Sang Hyun Cho -- Carbon nanotubes for thermal therapy / Ravi N. Singh ... [et al.] -- Regulatory issues for clinical translations / J. Donald Payne -- Clinical translations of nanotechnology : present and future outlook / Dev K. Chatterjee, Sang Hyun Cho, and Sunil Krishnan.
  • Overview -- Diagnostic studies -- Neurologic symptoms -- Direct complications of cancer -- Indirect complications of cancer -- Complications of cancer therapy -- Neurologic complications of specific malignancies.
  • Cancer of the testis 2010, Springer
    The book covers the complete field of testis cancer including the germ cell tumors and the stromal tumors, from epidemiology to new chemotherapeutic agents and schedules, throughout genetic features, risk factors, risk adapted treatments, role of different types of surgery and special clinical situations. Special attention is focused on fertility issues, late effects of the primary therapy and the economical aspects of the different treatment policies. As a result of the third Consensus Conference, a consensual follow-up can be devised and a chapter dedicated to this controversial and not yet defined matter.
  • Cancer pain 2013, Springer
    Cancer remains a major challenge for medicine and it continues to claim lives and cause great suffering. Pain is a symptom experienced by most cancer patients regardless of disease stage, and less than 50% of cancer pain patients achieve effective pain and symptom control though available therapies. If these therapies are utilized correctly, many more patients can achieve effective control. While opioids are still seen as the mainstay of cancer pain treatment, it is necessary to examine whether this treatment strategy still holds true in the 21st century. Cancer Pain provides a comprehensive, up-to-date, practical guide to the management of pain in cancer patients. The book provides a clear, concise explanation of cancer pain syndromes, a modern understanding of the pathophysiological mechanism and an overview of recent developments in creating pre-clinical cancer pain models. It offers the reader the wide and improved options for management of cancer pain in clinical practice, including the use of opioid and non-opioid drugs, and defines the role of non-pharmacological methods for pain control. Cancer Pain also provides an overview of the latest developments in the management of cancer, which have major implications for the current and future thinking in cancer pain treatment strategy. This text is an invaluable resource for doctors, trainees and clinical nurse specialists in palliative medicine and oncology, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of cancer pain and the tools available to alleviate it.
  • Cancer prevention 2007, Springer
  • Cancer prevention. II 2009, Springer
  • Cancer proteomics 2008, Springer
    Proteomics technologies -- Cell signaling proteomics -- Tumor proteomics -- Bioinformatics and regulatory aspects of proteomics.
  • Cancer stem cells 2007, Springer
  • Cancer stem cells : historical perspectives and lessons from leukemia / Christopher R. Cogle -- Cancer stem cells in breast cancer / Jenny E. Chu and Alison L. Allan -- Cancer stem cells in brain cancer / Xin Wang, Chitra Venugopal, and Sheila K. Singh -- Cancer stem cells in colorectal cancer / Mauro Biffoni, Eros Fabrizi, and Lucia Ricci-Vitiani -- Cancer stem cells in pancreatic cancer / Jorge Dorado, Alicia G. Serrano, and Christopher Heeschen -- Cancer stem cells in prostate cancer / Paula Kroon ... [et al.] -- Cancer stem cells in melanoma / Ping Jin ... [et al.] -- Cancer stem cells in lung cancer / Jun Shen and Feng Jiang -- Cancer stem cells in ovarian cancer / Fang Fang ... [et al.] -- Cancer stem cells in hepatocellular cancer / Russell C. Langan and Itzhak Avital -- Cancer stem cells in head and neck cancer / Mark E.P. Prince and Samantha J. Davis -- Relationship between regulatory pathways in pluripotent stem cells and human tumors / Olga Gaidarenko and Yang Xu -- Influence of the embryonic microenvironment on tumor progression / Daniela Quail ... [et al.] -- The epithelial-to-mesenchymal transition and cancer stem cells / Jonas Fuxe -- Application of stem cell assays for the characterization of cancer stem cells / Pamela M. Willan and Gillian Farnie -- Zebrafish as a model to study stem cells in development, disease, and cancer / Viviana Anelli, Cristina Santoriello, and Marina C. Mione -- Imaging cancer stem cells / Paula Foster -- Mouse models for studying normal and cancer stem cells / David A. Hess -- Cancer stem cells and disease prognosis / Zeshaan A. Rasheed, Jeanne Kowalski, and William H. Matsui -- Mechanisms of radioresistance in cancer stem cells / Cleo Y-F Lee and Maximilian Diehn -- The role of ABC transporters in cancer stem cell drug resistance / Vera S. Donnenberg, Ludovic Zimmerlin, and Albert D. Donnenberg -- Resistance to endocrine therapy in breast cancer : are breast cancer stem cells implicated? / Ciara S. O'Brien ... [et al.] -- Future directions : cancer stem cells as therapeutic targets / Alysha K. Croker and Alison L. Allan -- Final thoughts : complexity and controversy surrounding the "cancer stem cell" paradigm / Craig Gedye, Richard P. Hill, and Laurie Ailles.
  • Cancer survivorship 2007, Springer
    Cancer survivors: a physician's perspective / Patricia A. Ganz -- Cancer survivorship: a nursing perspective / Susan Leigh -- Oncology social work for survivorship / Patricia Fobair -- Survivorship research: past, present, and future / Julia H. Rowland -- Surveillance after primary therapy / Craig C. Earle -- Late effects of cancer treatments / Noreen M. Aziz -- Medical and psychosocial issues in childhood cancer survivors / Smita Bhatia ... [et al.] -- Medical and psychosocial issues in Hodgkin's disease survivors / Jon Håvard Loge and Stein Kaasa -- Medical and psychosocial issues in testicular cancer survivors / S.D. Fosså, L.B. Travis, and A.A. Dahl -- Medical and psychosocial issues in gynecologic cancer survivors / Karen Basen-Engquist and Diane C. Bodurka -- Medical, psychosocial, and health-related quality of life issues in breast cancer survivors / Julie Lemieux, Louise J. Bordeleau, and Pamela J. Goodwin -- Medical and psychosocial issues in prostate cancer survivors / Tracey L. Krupski and Mark S. Litwin -- Physical and psychosocial issues in lung cancer survivors / Linda Sarna, Frederic W. Grannis, and Anne Coscarelli -- Cancer survivorship issues in colorectal cancer / Clifford Y. Ko and Patricia A. Ganz -- Medical and psychosocial issues in transplant survivors / Karen L. Syrjala ... [et al.] -- Cancer survivorship issues in older adults / Karim S. Malek and Rebecca A. Silliman -- Second malignancies after radiation treatment and chemotherapy for primary cancers / Lydia B. Zablotska, Matthew J. Matasar, and Alfred I. Neugut -- Psychosocial rehabilitation in cancer care / Richard P. McQuellon and Suzanne C. Danhauer -- Reproductive complications and sexual dysfunction in cancer survivors / Leslie R. Schover -- The employment and insurance concerns of cancer survivors / Barbara Hoffman -- Cancer advocacy / Ellen L. Stovall -- The survivorship care plan: what, why, how, and for whom / Craig C. Earle ... [et al.]
  • Cancer susceptibility 2010, Springer Protocols
  • Cancer systems biology 2010, CRCnetBASE
    A roadmap of cancer systems biology / Edwin Wang -- Network biology : the framework of systems biology / Jing-Dong Han -- Reconstructing gene networks using gene expression profiles / Mario Lauria and Diego di Bernardo -- Understanding cancer progression in protein interaction networks / Jinsheng Sun, Jie Li, and Edwin Wang -- From tumor genome sequencing to cancer signaling maps / Cong Fu and Edwin Wang -- Ubiquitin-mediated regulation of human signaling networks in normal and cancer cells / Cong Fu, Jie Li, and Edwin Wang -- MicroRNA regulation of networks of normal and cancer cells / Pradeep Kumar Shreenivasaiah, Do Han Kim, and Edwin Wang -- Network model of survival signaling in T-cell large granular lymphocyte leukemia / Ranran Zhang, Thomas P. Loughran Jr., and Réka Albert -- Cancer metabolic networks : metabolic pathways modelling and metabolomics in cancer research / Miroslava Cuperlovic-Culf -- Warburg revisited : modeling energy metabolism for cancer systems biology / Mathieu Cloutier --Cancer gene prediction using a network approach / Xuebing Wu and Shao Li -- Cancer genomics to cancer biology / Maria Luz Jaramillo and Chabane Tibiche -- Epithelial-to-mesenchymal transition (EMT) : the good, the bad, and the ugly / Anne EG Lenferink -- Tumors and their microenvironments / Nicholas R. Bertos and Morag Park -- Tumor angiogenesis : cell-microenvironment interactions / Ally Pen, Danica B. Stanimirovic, and Maria J. Moreno -- Modeling tools for cancer systems biology / Wayne Materi and David S. Wishart -- Advanced visualization, analysis, and inference of biological networks using visANT / Zhenjun Hu -- Gene set and pathway-based analysis for cancer omics / Dougu Nam and Seon-Young Kim -- SH2 domain signaling network and cancer / Shawn S.-C. Li and Thamara K.J. Dayarathna -- Data sources and computational tools for cancer systems biology / Yun Ma, Pradeep Kumar Shreenivasaiah, and Edwin Wang.
  • pt. 1. Introduction and background -- pt. 2. Laboratory, clinical, data and educational resources -- pt. 3. Bioinformatics and systems biology analysis -- pt. 4. Diagnosis, clinical and treatment applications -- pt. 5. Perspectives and conclusions.
  • Cancer treatment and research v. 122-, 2004-, Springer
  • The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging --Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas --Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • Introduction for scientists -- Introduction for laypersons -- What cancers are -- Environmental and other causes of cancer -- Resources used to detect local increases in risk -- Methods used to detect local increases in risk -- Errors due to chance -- Comparison between "apples" and "oranges" -- Failure to detect local increases in risk -- Investigating a lead -- Guide to the figures -- Interpretation -- Scientific and technical notes -- Oropharyngeal carcinoma -- Salivary gland malignancies -- Squamous carcinoma of the esophagus/gastric cardia -- Adenocarcinoma of the esophagus/gastric cardia -- Adenocarcinoma of the (lower) stomach -- Carcinoma of the small intestine -- Colon carcinoma, total (both upper and sigmoid) -- Carcinoma of the upper colon -- Carcinoma of the sigmoid colon -- Carcinoma of the rectum -- Hepatocellular carcinoma -- Cholangiocarcinoma -- Gallbladder carcinoma -- Biliary tract carcinoma -- Pancreas carcinoma -- Carcinoma of the nose/sinuses -- Carcinoma of the larynx -- Lung and bronchus carcinoma, total (all types) -- Squamous cell carcinoma of the lung and bronchus -- Large cell carcinoma of the lung and bronchus -- Small cell carcinoma of the lung and bronchus -- Adenocarcinoma of the lung and bronchus -- Bronchioloalveolar carcinoma of the lung and bronchus -- Undifferentiated carcinoma of the lung and bronchus -- Carcinoma of the lung and bronchus, not otherwise classified -- Mesothelioma -- Soft tissue sarcoma -- Angiosarcoma -- Kaposi sarcoma -- Osteosarcoma -- Ewing's sarcoma -- Malignant chordoma -- Malignant melanoma -- Breast carcinoma -- Squamous cervix carcinoma (invasive) -- Endometrial (uterine corpus) carcinoma -- Epithelial carcinoma of the ovary -- Germ cell malignancies --Prostate carcinoma -- Anogenital adenocarcinoma -- Anogenital squamous carcinoma -- Mixed cell genital tumors -- Transitional cell (non-squamous) bladder carcinoma -- Squamous bladder carcinoma -- Renal cell carcinoma -- Wilms tumor (nephroblastoma) -- Retinoblastoma -- Brain malignancies (gliomas) -- Spinal cord malignancies -- Neurolemoma (nerve sheath malignancy) -- Neuroblastoma -- Malignant meningioma -- Papillary carcinoma of the thyroid -- Follicular carcinoma of the thyroid -- Other carcinoma of the thyroid -- Pituitary carcinoma -- Multiple endocrine neoplasia -- Carcinoma of the thymus -- Mixed cellularity Hodgkin lymphoma -- Nodular sclerosis Hodgkin lymphoma -- Other Hodgkin lymphoma -- All non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Follicular non-Hodgkin lymphoma -- Diffuse large B-cell non-Hodgkin lymphoma -- Diffuse small lymphocytic or plasmacytic B-cell non-Hodgkin lymphoma -- Diffuse mixed B-cell non-Hodgkin lymphoma -- High-grade non-Hodgkin lymphoma -- T-cell non-Hodgkin lymphoma -- Maltoma non-Hodgkin lymphoma -- Other non-Hodgkin lymphoma -- Central nervous system non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Stomach non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Other gastrointestinal non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Lymph node/other organ non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Multiple myeloma -- Acute lymphoblastic leukemia -- Chronic lymphocytic leukemia -- Hairy cell leukemia -- Acute non-lymphocytic leukemia -- Chronic myelocytic leukemia -- Other leukemias -- All malignancies of infants/toddlers -- All malignancies of older children -- All malignancies of young adults -- All malignancies of older adults -- All malignancies -- Overall summary.
  • Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
  • Cardiac tumor pathology 2013, Springer
    Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.
  • Caveolins and caveolae 2012, Springer
    Lipid rafts, caveolae, and GPI linked proteins / Valerie L. Reeves, Candice M. Thomas, and Eric J. Smart -- Caveolae and the regulation of endocytosis / Anna L. Kiss -- Caveolin : role in cell signaling / Cecile Boscher and Ivan Robert Nabi -- Regulation of ENOS in caveolae / Chieko Mineo and Philip W. Shaul -- Recent developments in the interactions between caveolin and pathogens / Fabiana S. Machado ... [et al.] -- Caveolin and breast cancer : a new clinical perspective / Isabelle Mercier and Michael P. Lisanti -- Caveolin and prostate cancer progression / Michael R. Freeman, Wei Yang, and Dolores Di Vizio -- Caveolins and caveolae, roles in insulin signalling, and diabetes / Peter Strolfors -- Atherosclerosis, caveolae, and caveolin / Stephanos Pavlides ... [et al.] -- Caveolins and heart diseases / Mathivadhani Panneerselvam, Hemal H. Patel, and David M. Roth -- Caveolins and lung function / Nikolaos A. Maniatis ... [et al.].
  • 1. Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression / T.C. Thompson, S.A. Tahir, L. Li, M. Watanabe, K. Naruishi, G. Yang, Ken-ichi Tabata, S. Kurosaka, K. Edamura, R. Tanimoto, P. Corn, D. Kadmon, C.J. Logothetis, P. Troncoso, C. Ren, A. Goltsov, and S. Park -- 2. Caveolin-1 in Colon Cancer: The Flexible Connection to Wnt Signaling / Andrew F.G. Quest, Vicente A. Torres, Diego A. Rodriguez, Jorge Gutierrez-Pajares, and Julio C. Tapia -- 3. Caveolin-1 and Pancreatic Ductal Adenocarcinoma / David W. Rittenhouse, Oeendree Mukherjee, Nathan G. Richards, Charles J. Yeo, Agnieszka K. Witkiewicz, and Jonathan R. Brody -- 4. Caveolin-1 in Brain Tumors / Rebecca Senetta and Paola Cassoni -- 5. The Role of Caveolin-1 in Skin Cancer -- / Alessandra Carè, Isabella Parolini, Federica Felicetti, and Massimo Sargiacomo -- 6. Caveolins in Tumor Angiogenesis / Grzegorz Sowa -- 7. Caveolin-1 and Breast Cancer / Gloria Bonuccelli and Michael P. Lisanti -- 8. Caveolin-1 and Cancer-Associated Stromal Fibroblasts / Isabelle Mercier and Michael P. Lisanti.
  • Defects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients. Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies. In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death. Each chapter also highlights recent advances in the translation of basic research findings into clinical trials. Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens. The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes. Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways. Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities. In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies.
  • Cancer Morbidity and mortality result from invasive and metastatic spread. Advances in the field have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book presents an overview of these studies.
  • 1. GRB2 Signaling as a Molecular Target for Cancer / Alessio Giubellino -- 2. Human Arylamine N-acetyltransferase 1: From Drug Metabolism to Drug Target / Fernando Rodrigues-Lima, Julien Dairou, Florent Busi, and Jean-Marie Dupret -- 3. Targeting Argininosuccinate Synthetase in Cancer Therapy / Niramol Savaraj, Min You, Chunjing Wu, Macus Tien Kuo, Vy Dinh, Medhi Wangpaichitr, and Lynn Feun -- 4. Parathyroid Hormone-Related Peptide Signaling in Cancer / Franco Oreste Ranelletti and Giovanni Monego -- 5. Signalling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma / Francesco Piazza and Gianpietro Semenzato -- 6. Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract / Hiroshi Yasuda and Fumio Itoh -- 7. AIB1: A Transcriptional Coactivator Which Integrates Signaling Cross Talk in Cancer Cells / Macarena Ferrero and Jaime Font de Mora -- 8. Rational Design of DNA Anticancer Agent That Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy / Naijie Jing -- 9. Estrogen Receptor Signaling in Lung Cancer / P.A. Hershberger and J.M. Siegfried -- 10. Microparticle Dissemination of Biological Activities: Implications for Cancer Biology / Pauline P. Goh -- 11. Protein Kinase D Signaling in Cancer / Peter Storz -- 12. Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants / Peter Kovacic and Ratnasamy Somanathan -- 13. Targeting Signal Transducer and Activator of Transcription (STAT) for Anticancer Therapy / Fabio P.S. Santos, Inbal Hazan-Halevy, and Zeev Estrov.
  • The Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. Central Nervous System Intraoperative Cytopathology is a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.
  • Introduction to brain metastasis /Diane Palmieri --Molecular biology of brain metastasis /Stephan Woditschka ... [et al.] --Brain microenvironment /Mami Noda --Vascular permeability within brain metastases /Chris E. Adkins ... [et al.] --Imaging experimental brain metastases /Amanda M. Hamilton and Paula J. Foster --Possibilities of targeted therapies for brain metastasis /Frank Winkler --Surgery for brain metastasis /Douglas L. Stofko, Robert J. Weil, and Steven A. Toms --Is there a role for systemic chemotherapy in the treatment of brain metastases /Marc C. Chamberlain --Radiation therapy of CNS metastases /DeeDee Smart --Leptomeningeal metastasis /Priscilla K. Brastianos, Charilaos H. Brastianos, and April F. Eichler --Quality of life with CNS metastasis /Lauren A. Chandler and Kathleen L. Fuchs.
  • Checkpoint controls and cancer v. 1-2, 2004., Springer Protocols
    v. 2, 2004 Springer Protocols
    v. 1. Reviews and model systems -- v. 2. Activation and regulation protocols.
  • Chemical carcinogenesis 2011, Springer
    Historical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
  • Introduction to cancer -- Antimetabolites -- DNA-interactive agents -- Antitubulin agents -- Cell signaling inhibitors -- Hormonal therapies -- Tumour targeting strategies -- Biologicals -- The future -- Personalized medicine (oncogenomics) -- Adjunct therapies.
  • Chemo fog 2010, Springer
    Short introduction and history / Robert B. Raffa -- Patient's perspective / Robert B. Raffa and Kathy Martin -- Oncology nurse's perspective / Jamie S. Myers -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Neurocognitive effects of childhood cancer treatment / Jennifer Costa -- The economic burden / Albert I. Wertheimer -- Designing conceptual model-based research in chemotherapy-related changes in cognitive function / Lisa M. Hess -- Neuropsychologic testing for chemotherapy-related cognitive impairment / Jamie S. Myers -- Imaging as a means of studying chemotherapy-related cognitive impairment / Robert B. Raffa -- Chemotherapy associated central nervous system damage / Jørg Dietrich -- Is systemic anti-cancer therapy neurotoxic? Does chemo brain exist? And should we rename it? / Sophie Taillibert -- Evaluation of multiple neurotoxic outcomes in cancer chemotherapy / Bernard Weiss -- Chemotherapy-related visual system toxicity / Robert B. Raffa -- The possible role of cytokines in chemotherapy-induced cognitive deficits / Jamie S. Myers -- Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy / Swati Nagar -- Combination analysis / Ronald J. Tallarida -- Animal models / Ellen A. Walker -- Chemo brain (chemo fog) as a potential side effect of doxorubicin administration : role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction / Christopher D. Aluise ... [et al.] -- Effects of 5-FU / Peter M. Wigmore ... [et al.] -- Future directions / Robert B. Raffa and Ronald J. Tallarida.
  • Chemosensitivity v. 1-2, 2005., Springer Protocols
    v. 2, 2005 Springer Protocols
    v. 1. In vitro assays -- v. 2 In vitro models, imaging, and molecular regulators.
  • Scientific basis of cancer chemotherapy -- Norton-simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Continuous intravenous infusion chemotherapy -- Intraarterial chemotherapy -- Isolated regional therapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of chemotherapy -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of antineoplastic therapy -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Renal and electrolyte abnormalities due to chemotherapy -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- General issues in brain tumor chemotherapy -- Chemotherapy of head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestinal cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancers -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy of hodgkin's lymphoma -- Non-hodgkin's lymphoma -- Acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia -- Chemotherapy of the myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma and other plasma cell disorders.
  • 1. Introducing Cancer -- 2. Boveri's theory of cancer was ahead of its time -- 3. Genesis of "The enemy within"? -- 4. Gene mutation theory of cancer -- 5. The chromosomal imbalance theory of cancer -- 6. Theory of chromosomal imbalance solves mysteries and paradoxes -- 7. New perspectives for cancer prevention, diagnosis and therapy.
  • This book comprises an in-depth view on the current knowledge of chronic clonal myeloid diseases. Special emphasis is laid on chronic myeloid leukaemia and a'classic' myeloproliferative disorders (essential thrombocythemia, polycythemia vera, and chronic idiopathic myelofibrosis) as well as myelodysplastic syndromes, oligoblastic leukemias, paroxysmal nocturnal hemoglobinuria and overlap diseases. Both young physicians in hematological training as well as practicing hematologists are addressed, with the aim of imparting a clear understanding of these disorders.
  • SPECT/CT cameras have considerably improved diagnostic accuracy in recent years. Such cameras allow direct correlation of anatomic and functional information, resulting in better localization and definition of scintigraphic findings. In addition to this anatomic referencing, CT coregistration provides superior quantification of radiotracer uptake based on the attenuation correction capabilities of CT. Useful applications of SPECT/CT have been identified not only in oncology but also in other specialties such as orthopedics and cardiology. This book covers the full spectrum of clinical applications of SPECT/CT in diagnosis and therapy planning of benign and malignant diseases. Opening chapters discuss the technology and physics of SPECT/CT and its use for dosimetry. The role of SPECT/CT in the imaging of a range of pathologic conditions is then addressed in detail. Applications covered include, among others, imaging of the thyroid, bone, and lungs, imaging of neuroendocrine tumors, cardiac scintigraphy, and sentinel node scintigraphy. Individual chapters are also devoted to therapy planning in selective internal radiation therapy of liver tumors and bremsstrahlung SPECT/CT. Readers will find this book to be an essential and up-to-date source of information on this invaluable hybrid imaging technique.
  • Introduction to Electroporation -- Electroporation and Cellular Physiology -- The Cell in the Electric Field -- Understanding Electric Fields for Clinical Use -- Generators and Applicators: Equipment for Electroporation -- Cell Electropermeabilization and Cellular Uptake of Small Molecules: The Electrochemotherapy Concept -- Vascular-Disrupting Action of Electrochemotherapy: Mode of Action and Therapeutic Implications -- Electrochemotherapy of Small Tumors; The Experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) Group -- Electrochemotherapy for Larger Malignant Tumors -- Cell Electroporation in Bone Tissue -- Drug and Gene Electrotransfer to the Brain -- Minimally Invasive Intraluminal Tumor Ablation -- Electrotransfer of Plasmid DNA -- Gene Electrotransfer to Tumor -- Gene Electrotransfer to Lung -- Gene Electrotransfer to Muscle Tissue: Moving into Clinical Use -- Gene Electrotransfer to Skin -- Electroporation-Mediated DNA Vaccination -- Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research -- Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck -- Clinical Research on Irreversible Electroporation of the Liver.
  • Skin tumors are very often encountered in clinical practice but can be difficult to diagnose since the skin's histological complexity gives rise to many types and subtypes. This superb atlas presents an unrivalled wealth of original high-quality clinical photographs of almost all benign and malignant skin tumors. The diverse subtypes and clinical forms, including different localizations, are depicted, and careful attention is paid to evolution and follow-up. While the main focus is on the clinical presentation as reflected in the photographs, diagnostic clues and management considerations are also summarized in a straightforward, readily understandable way. The atlas has been designed so that it will meet clinical needs and allow rapid identification of clues relevant to daily practice. Clinical Atlas of Skin Tumors will be valuable for all dermatologists in training, as well as for those who are already established in the profession or in allied specialties such as plastic surgery and oncology.
  • My Aunt Minnie -- Screening -- Diagnostic breast imaging -- Management.
  • Clinical cancer genetics 2012, Wellcome Trust
    Transcript / edited by E M Jones and E M Tansey -- Appendix 1. Timeline for UK Clinical Cancer Genetics Groups -- Appendix 2. Archival material from St Mark's Polyposis Registry -- Register cards / interpreted by Ms Kay Neale -- Letter from Dr C Dukes to Dr J C Burne -- Adaptation of poem, You Are Old Father William / by Dr C Dukes -- Obituary for Dr H J R Bussey / by Basil Morson -- Appendix 3. Pedigree of a Newfoundland family, 'Family C', with HNPCC -- Appendix 4. -- Cancer Genetics: a personal view / Professor David Harnden -- Glossary -- Biographical notes.
  • The main themes in this volume are the latest advances in the prevention of breast and prostate cancer and the role of infection in the development of liver and gastric cancer. Special emphasis is given to perspectives on the chemoprevention of breast cancer.
  • Conceived as a guide for practitioners in their work in dermatology, this book is unique in its approach. From cutaneous signs to the richness of differential diagnosis, it guides practitioners through every step, from semiological analysis to diagnosis. The aim is to provide readers with the essentials of relevant dermatological reasoning. The first part of the book focuses on physical examination and on recognizing basic lesions, the practitioners building blocks. The diseases requiring understanding are then described in the form of a richly illustrated atlas, in which each diagram has been chosen as an exemplary educational tool. In the final part, differential diagnosis is proposed in the form of various tables summarizing the different cutaneous signs, providing readers with a complete toolkit to assist with diagnosis. This book will give trainee dermatologists, general physicians and internists the knowledge they need to identify basic lesions and a complete and detailed overview of the various diseases they are likely to encounter. At the same time, experienced dermatologists will find this book a valuable reference work for differential diagnosis.
  • Clinical management of thyroid cancer / Kennichi Kakudo & Zhiyan Liu -- Diagnosis of thyroid cancer / Joseph M. Shulan & Jennifer A. Sipos -- Thyroid cancer : classification and cytological diagnosis / Zvonimir L. Milas, Jennifer Brainard & Mira Milas -- Molecular genetics of thyroid cancer / Angela Greco, Claudia Miranda, Maria Grazia Borrello & Marco A. Pierotti -- Etiopathogenic factors of thyroid cancer / Ana Lourenço Almeida, Paula Boaventura & Paula Soares -- Differentiated thyroid carcinoma: prognostic stratification and molecular classification / Michele N. Minuto, Emanuela Varaldo & Giuseppina Talamo -- Radiotherapy : radioiodine and external beam irradiation treatment of differentiated thyroid carcinomas / Miguel Melo, Gracinda Costa, Francisco Carrilho, Manuela Carvalheiro & Paula Soares -- Borderline lesions in thyroid tumor classification and well-differentiated tumor of uncertain malignant potential Zhiyan Liu, Bo Han, Yanhua Bai, Yaqiong Li, Osamu Nunobiki & Kennichi Kakudo -- Differentiated thyroid cancer in children / Andrew J. Bauer, Catherine A. Dinauer, Steven G. Waguespack & Gary L. Francis -- Index.
  • Print Material
  • 1. Principles of Clinical Epidemiology / Annette C. Moll, Michiel R. de Boer, Lex M. Bouter, and Nakul Singh -- 2. Etiology of Cancer / Brian T. Hill -- 3. Cancer Pathology / Katarina Bartuma, Charlotta All-Ericsson, and Stefan Seregard -- 4. Cancer Angiogenesis / Werner Wackernagel, Bela Anand-Apte, and Arun D. Singh -- 5. Immunology of Ocular Tumors / Martine J. Jager and Inge H.G. Bronkhorst -- 6. Cancer Genetics / J.William Harbour and Daniel L. Chao -- 7. Cancer Staging / Paul T. Finger -- 8. Principles of Cryotherapy / Dan S. Gombos -- 9. Principles of Laser Therapy / Stefan Sacu and Ursula Schmidt-Erfurth -- 10. Principles of Radiation Therapy / Abigail L. Stockham, Ehsan H. Balagamwala, Roger Macklis, Allan Wilkinson, and Arun D. Singh -- 11. Ocular Complications of Radiotherapy / Mitchell Kamrava, James Lamb, and Tara A. McCannel -- 12. Principles and Complications of Chemotherapy / Michael G. Levien, Nicola G. Ghazi, and Arun D. Singh -- 13. Targeted Therapy and Their Ocular Complications / Denis Jusufbegovic, Pierre L. Triozzi, and Arun D. Singh -- 14. Counseling Patients with Cancer / Laura Hope-Stone and Bertil Damato -- 15. Cataract Associated with Intraocular Tumors / Carlos A. Medina, Mary E. Aronow, and Arun D. Singh -- 16. Tumor-Associated Glaucoma / Reena S. Vaswani, Kathryn Bollinger, Annapurna Singh, and Arun D. Singh -- 17. Graft-Versus-Host Disease / Edgar M. Espana, Sejal Shah, and Arun D. Singh -- 18. Uveal Tumors: Diagnostic Techniques: Angiography / Kaan Gunduz, Jessica A. Adefusika, Thomas P. Link, and Jose S. Pulido -- 19. Diagnostic Techniques: Optical Coherence Tomography / Rubens Belfort, Andre Romano, Eduardo Rodrigues, and Arun D. Singh -- 20. Diagnostic Techniques: Autofluorescence / Edoardo Midena, Elisabetta Pilotto, and Raffaele Parrozzani -- 21. Diagnostic Techniques: Ophthalmic Ultrasonography / Brandy Hayden Lorek, Mary E. Aronow, and Arun D. Singh.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors are carefully explained, and treatment options are considered in detail.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations Locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.
  • "This volume, devoted solely to uveal tumors, explains the various diagnostic and biopsy techniques that may be used and describes the therapeutic options of potential value for different types of tumor."--Publisher's website.
  • This book, unique in focusing specifically on cardiac masses, is the result of cooperation among a number of teams of radiologists working under the aegis of the French Society of Cardiovascular Imaging (SFICV). Its goal is to 1) review the different CMR sequences and CT acquisition protocols used to explore cardiac masses, 2) to demonstrate the several CMR and MDCT features of cardiac masses. It has been designed as a teaching tool and offers a fully illustrated compendium of clinical cases, tables summarizing data, and decision-making trees essential in everyday practice. It is presented as a practical handbook and can be either read cover to cover or consulted whenever needed during a cardiac imaging assignment. The book is intended for all students and experienced practitioners, whether radiologists or not, who are interested in cardiac or thoracic pathology.
  • CNS cancer 2009, Springer
    Covers three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors.
  • Coagulation consult 2014, Springer
    There have been many changes in the field of coagulation during the past decade. New concepts of epidemiology of risk factors for thrombosis now help clinicians predict who is more likely to form clots after surgery, or after being placed on oral contraceptives. New anticoagulants have the potential to redefine how patients with atrial fibrillation and venous thrombosis are managed. There are new forms of recombinant clotting factors which have changed our approach to hypofibrinogenemia and von Willebrand's disease. Newer antiplatelet agents are available and their use in patients receiving cardiac stents has mushroomed. The management of thrombosis in the setting of pregnancy has changed over the past decade, as well as the way clinicians approach women with multiple miscarriages. An entire new class of compounds, the thrombopoietins, are available to treat individuals with immune thrombocytopenic purpura (ITP). The Coagulation Consult covers major topics of interest to hematologists who are asked to consult on individuals with coagulation related diseases, and encompasses the field's most recent developments. This "case-directed" book describes state-of-the-art approaches to patients with bleeding and clotting disorders, as well as laboratory tests for coagulation. Chapters include different vignettes, focus on typical clinical consult questions, and lay out specific types of treatment. Practicing clinicians being confronted with a coagulation consult, students, residents, fellows and attending physicians will find this unique text an invaluable resource for some of the newer areas of coagulation science, therapy and pharmacology.
  • Coagulation in cancer 2009, Springer
  • Metallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
  • Colorectal cancer 2007, Springer
    Molecular biology of colon cancer / William M. Grady -- Chemoprevention of colorectal cancer / Yu-Ning Wong ...[et al.] -- Colorectal cancer screening and surveillance / Arnold J. Markowitz -- Cytotoxic chemotherapy for metastatic colorectal cancer / M. Wasif Saif, Richard Kim, and Edward Chu -- Integration of antiangiogenic strategies in colorectal cancer treatment / John M. Strother and Charles D. Blanke -- The role of EGFR inhibition in colorectal cancer / Nabeel Shalan and Paulo M. Hoff -- Second-line strategies in the treatment of patients with metastatic colorectal cancer / Anthony B. El-Khoueiry and Heinz-Josef Lenz -- Adjuvant chemotherapy for colon cancer / Bert H. O'Neil ... [et al.] -- Management of locally advanced rectal cancer / Yu Jo Chua and David Cunningham -- Rationale for adjuvant and neoadjuvant chemotherapy in the resection of liver metastases / Axel Grothey and Steven A. Alberts -- Percutaneous radiofrequency ablation in the management of patients with colorectal cancer / Karen Brown -- Colorectal cancer imaging / Sean D. Curran and Laurence H. Schwartz -- Nursing issues in colorectal cancer chemotherapy / Ellen Hollywood and Deborah Semple -- Pain management in the colorectal cancer patient / Vivek Tim Malhotra -- Novel agents and new paradigms for colorectal cancer / Chris Takimoto and Russell Kruzelock.
  • Colorectal cancer 2009, Springer
  • As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. Disease management in these patients poses a unique challenge as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. Appropriate management of elderly patients demands a greater understanding of not only the physiological changes but also issues related to the delivery of holistic care. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.
  • Colorectal cancer pathways / Petr Protiva -- Risk factors and screening for colorectal cancer / Joseph C. Anderson -- Hereditary adenomatous colorectal cancer syndromes / Maqsood Khan and Carol A Burke -- Screening and surveillance guidelines / Robert J. Chehade and Douglas J. Robertson -- Barriers to colorectal cancer screening : patient, physician, and system factors / Catherine R. Messina -- Screening for colorectal cancer using colonoscopy / Douglas K. Rex -- New colonoscopic technologies for colorectal cancer screening / Douglas K. Rex -- Screening for CRC using CT colonography / Brooks D. Cash -- Noninvasive screening tests / Nabil Fayad and Thomas F. Imperiale -- Removal of difficult colon polyps / Jerome Waye -- Screening for colorectal cancer in the elderly / Charles J. Kahi -- Chemoprevention / Jeffrey Singerman and Petr Protiva.
  • Targeting of the EGFR as a modulator of cancer chemotherapy / Jose Baselga -- Cyclin dependent kinase inhibitors in combination chemotherapy / Manish A. Shah and Gary K. Schwartz -- Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia / Steven Grant -- Carboxyamidotriazole, an inhibitor of nonvoltage operated calcium entry : single agent and combination therapy for ovarian carcinoma / Chad M. Michener and Elise C. Kohn -- Targeted alpha particle therapy : a rational approach to drug development in hematologic diseases and solid tumors / John M. Burke, David A. Scheinberg, and Joseph G. Jurcic -- Pharmacologic modulation of fluoropyrimidines : building upon the lessons of the past / Owen A. O'Connor -- Development of inhibitors of HER2 with taxanes : new directions in breast cancer therapy / Shanu Modi, Monica N. Fornier, and Andrew D. Seidman -- Targeting nf-b to increase the activity of cisplatin in solid tumors / Don S. Dizon ... [et al.] -- Combinations of chemotherapy and G3139, an antisense BCL-2 oligonucleotide / Luba Benimetskaya, Sridhar Nami, and C. A. Stein -- Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy / Beverly A. Teicher.

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