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  • Introduction / M. Alma Rodriguez -- History of MD Anderson's tumor registry / Sarah H. Taylor -- Statistical methods / Geoffrey G. Giacco, Sarah H. Taylor and Kenneth R. Hess -- Breast cancer / Aman U. Buzdar ... [et al.] -- Prostate cancer / Deborah A. Kuban ... [et al.] -- Non-small cell lung cancer / Ritsuko Komaki, Anne S. Tsao, and Reza J. Mehran -- Small cell lung cancer / Frank V. Fossella -- Colon cancer / Cathy Eng, Patrick Lynch, and John Skibber -- Ovarian cancer / Robert L. Coleman and David M. Gershenson -- Cervical cancer / Patricia J. Eifel and Charles Levenback -- Endometrial cancer / Thomas Burke ... [et al.] -- Pancreatic cancer (exocrine) / Jason Fleming ... [et al.] -- Kidney cancer / Scott E. Delacroix Jr. ... [et al.] -- Bladder cancer / Robert S. Svatek ... [et al.] -- Cutaneous melanoma / Jeffrey E. Gershenwald, Geoffrey G. Giacco, and Jeffrey E. Lee -- Liver cancer / Evan S. Glazer and Steven A. Curley -- Esophageal cancer / Linus Ho ... [et al.] -- Gastric cancer / Alexandria T. Phan and Paul F. Mansfield -- Acute myeloid leukemia / Emil J. Freireich -- Chronic lymphocytic leukemia/small lymphocytic lymphoma / Apostolia-Maria Tsimberidou and Michael J. Keating -- Hodgkin lymphoma / Michelle Fanale ... [et al.] -- Non-hodgkin indolent B-cell lymphoma / Sattva S. Neelapu -- Non-hodgkin aggressive B-cell lymphoma / M. Alma Rodriguez -- Multiple myeloma / Donna Weber and Raymond Alexanian -- Head and neck cancer / Ehab Hanna ... [et al.] -- Thyroid cancer / Steven I. Sherman, Nancy Perrier, and Gary L. Clayman -- Soft tissue sarcomas / Vinod Ravi, Raphael Pollock, and Shreyaskumar R. Patel -- Sarcomas of bone / Valerae Lewis.
  • AACR Education book 2005-
  • ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.
  • Part I. Science of Clinical Oncology -- Section A. Biology and Cancer -- 1. Molecular Tools in Cancer Research -- 2. Intracellular Signaling -- 3. The Cellular Microenvironment and Metastases -- 4. Control of the Cell Cycle -- 5. Pathophysiology of Cancer Cell Death -- 6. Cancer Immunology -- 7. Stem Cells, Cell Differentiation, and Cancer -- 8. Vascular and Interstitial Biology of Tumors -- Section B. Genesis of Cancer -- 9. Environmental Factors -- 10. DNA Damage Response Pathways and Cancer -- 11. Viruses and Human Cancer -- 12. Genetic Factors: Hereditary Cancer Predisposition Syndromes -- 13. Genetic and Epigenetic Alterations in Cancer -- 14. Immunodeficiency and Cancer -- Section C. Diagnosing Cancer -- 15. Flow Cytometry in Oncologic Diagnosis -- 16. WHO Classification of Hematologic Malignancies -- 17. Pathology, Biomarkers, and Molecular Diagnostics -- 18. Imaging -- Section D. Preventing and Treating Cancer -- 19. Biostatistics and Bioinformatics in Clinical Trials -- 20. Structures Supporting Cancer Clinical Trials -- 21. Oncology and Health Care Policy -- 22. Discovery and Characterization of Cancer Genetic Susceptibility Alleles -- 23. Cancer Prevention, Screening, and Early Detection -- 24. Nicotine Dependence: Current Treatments and Future Directions -- 25. Surgical Interventions in Cancer -- 26. Establishing and Maintaining Vascular Access -- 27. Basics of Radiation Therapy -- 28. Therapeutic Targeting of Cancer Cells: Era of Molecularly Targeted Agents -- 29. Cancer Pharmacology -- 30. Hematopoietic Stem Cell Transplantation -- 31. Gene Therapy in Oncology -- 32. Therapeutic Antibodies and Immunologic Conjugates -- 33. Complementary and Alternative Medicine -- Part II. Problems Common to Cancer and its Therapy -- Section A. Hematologic Problems and Infections -- 34. Disorders of Blood Cell Production in Clinical Oncology -- 35. Diagnosis, Treatment, and Prevention of Cancer-Associated Venous Thromboembolism -- 36. Infection in the Patient with Cancer -- Section B. Metabolic and Paraneoplastic Syndromes -- 37. Hypercalcemia -- 38. Tumor Lysis Syndrome -- 39. Paraneoplastic Neurologic Syndromes -- 40. Cancer-Related Pain -- 41. Cancer Cachexia -- 42. Nausea and Vomiting -- 43. Oral Complications -- 44. Dermatologic Toxicities of Anticancer Therapy -- 45. Fatigue -- 46. Caring for Patients at the End of Life -- Section C. Local Effects of Cancer and Its Metastasis -- 47. Acute Abdomen, Bowel/Biliary Obstruction, and Fistula -- 48. Superior Vena Cava Syndrome -- 49. Spinal Cord Compression -- 50. Brain Metastases and Neoplastic Meningitis -- 51. Bone Metastases -- 52. Lung Metastases -- 53. Liver Metastases -- 54. Malignant Effusions -- Section D. Complications of Therapy -- 55. Rehabilitation of Individuals with Cancer -- 56. Survivorship -- 57. Neurologic Complications -- 58. Pulmonary Complications of Anticancer Treatment -- 59. Cardiac Effects of Cancer Therapy -- 60. Reproductive Complications -- 61. Endocrine Complications -- 62. Second Malignant Neoplasms -- Section E. Special Populations -- 63. Cancer in the Elderly: Biology, Prevention, and Treatment -- 64. Special Issues in Pregnancy -- 65. Acquired Immunodeficiency Syndrome and Cancer -- Part III. Specific Malignancies -- 66. Cancer of the Central Nervous System -- 67. Eye, Orbit, and Adnexal Structures -- 68. Cancer of the Head and Neck -- 69. Melanoma -- 70. Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas -- 71. Cancer of the Endocrine System -- 72. Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer -- 73. Diseases of the Pleura and Mediastinum -- 74. Cancer of the Esophagus -- 75. Cancer of the Stomach and Gastroesophageal Junction -- 76. Cancer of the Small Bowel -- 77. Colorectal Cancer -- 78. Cancer of the Rectum -- 79. Cancer of the Anal Canal -- 80. Liver and Bile Duct Cancer -- 81. Carcinoma of the Pancreas -- 82. Cancer of the Kidney -- 83. Bladder Cancer -- 84. Prostate Cancer -- 85. Cancer of the Penis -- 86. Testicular Cancer -- 87. Cancers of the Cervix, Vulva, and Vagina -- 88. Uterine Cancer -- 89. Cancers Arising in the Ovary -- 90. Gestational Trophoblastic Disease -- 91. Cancer of the Breast -- 92. Sarcomas of Bone -- 93. Sarcomas of Soft Tissue -- 94. Carcinoma of Unknown Primary -- 95. Pediatric Solid Tumors -- 96. Childhood Leukemia -- 97. Childhood Lymphoma -- 98. Acute Leukemias in Adults -- 99. Myelodysplastic Syndromes -- 100. Myeloproliferative Neoplasms -- 101. Chronic Myeloid Leukemia -- 102. Chronic Lymphocytic Leukemia -- 103. Hairy Cell Leukemia -- 104. Multiple Myeloma and Related Disorders -- 105. Hodgkin Lymphoma -- 106. Non-Hodgkin Lymphoma -- 107. Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma -- 108. Adult T-Cell Leukemia-Lymphoma.
  • Print Material
  • Also available: Print – 2006
  • Also available: Print – 2007
    Approaching the treatment of AML from a biological perspective : an overview / Farhad Ravandi and Francis Giles -- Aberrant transcription factors in AML / Alan D. Friedman -- Myelodysplasia-related AML / Jane E. Parker -- Therapy-related AML / Lucy A. Godley and Michelle Le Beau -- The DNA damage response, DNA repair, and AML / David P. Steensma -- Altered apoptosis in AML : potential implications for pathogenesis and therapeutic response / Ruben A. Mesa and Scott H. Kaufmann -- Drug resistance transporters in AML / Douglas D. Ross -- Impact of cytogenetics on clinical outcome in AML / David Grimwade -- APL : a classic tale of bench to bedside / Olga Frankfurt ... [et al.] -- Emerging therapeutics for AML / Edward A. Sausville -- FLT3 : a prototype receptor tyrosine kinase target in AML / Mark Levis -- Farnesyl transferase inhibitors in the therapy of AML / Jeffrey E. Lancet -- Modulating gene expression as a therapeutic approach in the treatment of AML / Tamer Fandy, Hetty Carraway, and Steven D. Gore -- Differentiation therapy in AML / Tara L. Lin and William Matsui -- Stem cell transplantation for AML / Javier Bolaños-Meade and Richard J. Jones -- Tumor vaccines in leukemia / Ivan Borrello -- Treatment, outcomes, and challenges of newly diagnosed AML in children and adolescents / Robert J. Arceci -- AML in older adults / Richard M. Stone -- Dameshek smiles : molecular clues to the chronic myeloproliferative disorders unmasked / Jason Gotlib -- New designs for clinical trials / Elihu Estey.
  • Also available: Print – 2010
  • Also available: Print – yyyy
    APL as a paradigm in biomedical research : a journey toward the cure / P.P. Pandolfi -- Mouse models of acute promyelocytic leukemia / S.C. Kogan -- The PLZF gene of t(11;17)-associated APL / M.J. McConnell and J.D. Licht -- SUMO, the three Rs and cancer / J.-S. Seeler ... [et al.] -- Emerging role for microRNAs in acute promyelocytic leukemia / C. Nervi ... [et al.] -- The theory of APL revisited / P.P. Scaglioni and P.P. Pandolfi -- Treatment of acute promyelocytic leukemia by retinoids / P. Fenaux, Z.Z. Wang, and L. Degos -- Arsenic trioxide and acute promyelocytic leukemia : clinical and biological / Z. Chen ... [et al.] -- Front line clinical trials and minimal residual disease monitoring in acute promyelocytic leukemia / F. Lo-Coco and E. Ammatuna -- Histone deacetylase inhibitors in APL and beyond / K. Petrie, N. Prodomou, and A. Zelent -- Monoclonal antibody therapy of APL / P.G. Maslak, J.G. Jurcic, and D.A. Scheinberg -- Targeting APL fusion proteins by peptide interference / A. Melnick -- The design of selective and non-selective combination therapy for acute promyelocytic leukemia / Y. Jing and S. Waxman.
  • Extracellular matrix -- Cytoskeleton -- Pseudopodia and adhesion structures -- Adhesive interactions of tissue cells with the extracellular matrix -- Cell migration -- Cell responses to chemical heterogeneity of substrata: adhesive islets or paths -- Topographic cell responses -- Intercellular adhesive interactions.
  • Preface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index.
  • Also available: Print – 2009
  • "This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care."--Publisher's website.
  • A perspective on the treatment of acute lymphoblastic leukemia in adults -- Acute lymphocytic leukemia: clinical features and making the diagnosis -- The biology of adult acute lymphoblastic leukemia -- Minimal residual disease in acute lymphoblastic leukemia -- Cytogenetics -- Acute lymphoblastic leukemia: epidemiology -- Prognostic factors in adult acute lymphoblastic leukemia (ALL) -- The generalized care of the patient with acute lymphoblastic leukemia -- Treatment of acute lymphoblastic leukemia in middle-age and older adults -- Pharmacology of acute lymphoblastic leukemia therapy -- Assessment of response to treatment -- T-cell acute lymphoblastic leukemia -- Burkitt lymphoma and leukemia -- Treatment of acute lymphoblastic leukemia in young adults -- Philadelphia chromosome positive acute lymphoblastic leukemia -- Molecular therapies -- Treatment of relapsed acute lymphoblastic leukemia -- Allogeneic stem cell transplantation for acute lymphoblastic leukemia in adults -- Hematopoietic stem cell transplantation in Philadelphia-positive acute lymphoblastic leukemia -- Special challenges: genetic polymorphisms and therapy -- Late consequences of therapy of acute lymphoblastic leukemia -- Immunotherapy for acute lymphoblastic leukemia -- Unique subtypes in acute lymphoblastic leukemia.
  • Speakers at the symposium -- Stem cells in adult intestine / Feng, J., Sperka, T. -- Molecular mechanisms of muscle stem cell aging / Schwërer, S., Tümpel, S. -- Mechanism of functional alterations in hematopoietic stem cell aging / Morita, Y. -- The microenvironment, aging, and disease / Geiger, H. -- Sestrins in aging and metabolism / Tang, D., Tao S. -- Telomeres and stem cell aging / Felix, D.A. -- DNA damage and checkpoint responses in adult stem cells / Romanov, V., Shukla, A., Ju, Z.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
  • Advances in bone metastasis management / Piero Picci & Pietro Ruggieri -- Pathways to metastases : how do metastases develop in bone / Jeff Toreson & Robert E. Turcotte -- Metastatic spread to bone : the role of chemotherapy / Stefano Ferrari, Emanuela Palmerini, Andreas F. Mavrogenis & Pietro Ruggieri -- Bone stroma inhibition in prostate cancer / Michael A. Carducci & Daniel Keizman -- Management of bone metastases in breast cancer / Toni Ibrahim & Dino Amadori -- Radiotherapy for bone metastases / Julia Di Giovanni, Janet Nguyen, Marko Popovic & Edward Chow -- Bisphosphonates for bone metastases / Esther Chan & Urban Emmenegger -- Surgical treatment for spinal metastases / Roberto Casadei, Andreas F. Mavrogenis, Marco Manfrini & Pietro Ruggieri -- Surgical treatment for pelvic bone metastases / Andreas F Mavrogenis, Eugenio Brunocilla, Giuseppe Bianchi, Nicola Fabbri & Pietro Ruggieri -- Surgical treatment for metastatic pathological fractures / Andreas F. Mavrogenis, Roberto Casadei & Pietro Ruggieri -- Palliative treatments : selective arterial embolization for bone metastases / Giuseppe Rossi, Andreas F. Mavrogenis, Piero Picci & Pietro Ruggieri -- Palliative treatments : electrochemotherapy and thermoablation / Giuseppe Bianchi, Laura Campanacci, Eugenio Rimondi & Pietro Ruggieri -- Novel targeted therapies of bone tumors and future directions / Dominique Heymann -- Index.
  • Also available: Print – 2008
  • Breast magnetic resonance imaging (MRI) is becoming an increasingly valuable technology for breast cancer detection, especially for women at high risk for the disease. Stanford Hospital alone performed approximately 1,000 breast MRIs last year. This demand and need to increase specificity of breast MRI motivates improving current breast MR protocols, as well as exploring new applications of MR technology to breast imaging. Most clinical breast MR exams are performed at a 1.5T field strength. 3T scanners, however, are becoming more prevalent in the clinical setting and thus the breast MR protocol needs to be tuned accordingly. The first project includes measurements of T1 and T2 of breast fat and glandular tissue at 1.5T and 3T and the corresponding recommendation for altering the TR and TE for 3T breast imaging. The beating heart posterior to the breast often produces artifacts in breast MR images. The second project is a cylindrical saturation method that reduces unwanted signal from the heart while avoiding signal loss from the breast tissue of interest. Detecting tumor oxygenation non-invasively may give insight on tumor differentiation, predict susceptibility to antiangiogenic therapeutics, and monitor chemotherapeutics. The third project introduces the application of BOLD contrast imaging, a technique usually applied in functional brain MR imaging for characterizing tumor oxygenation in the breast.
  • 1. Cancer Stem Cells: A Revisitation of the "Anaplasia" Concept / Roberto Scatena -- 2. Stem Cells and Cancer Stem Cells: New Insights / Toru Kondo -- 3. Molecular Biology of Cancer Stem Cells / Oswaldo Keith Okamoto -- 4. Biomarkers of Cancer Stem Cells / Jun Dou and Ning Gu -- 5. Cancer Stem Cells and the Microenvironment / Alfonso Colombatti, Carla Danussi, Eliana Pivetta, and Paola Spessotto -- 6. Leukemia Stem Cells / Steven W. Lane and David A. Williams -- 7. Cancer Stem Cells and the Central Nervous System / Serdar Korur, Maria Maddalena Lino, and Adrian Merlo -- 8. Cancer Stem Cells and Glioblastoma Multiforme: Pathophysiological and Clinical Aspects / Akio Soeda, Mark E. Shaffrey, and Deric M. Park -- 9. Breast Cancer Stem Cells / Nuria Rodríguez Salas, Enrique González González, and Carlos Gamallo Amat -- 10. Colon Cancer Stem Cells / Ugo Testa -- 11. Liver Tumor-Initiating Cells/Cancer Stem Cells: Past Studies, Current Status, and Future Perspectives / Kwan Ho Tang, Stephanie Ma, and Xin-Yuan Guan -- 12. Pancreatic Cancer Stem Cells / Erica N. Proctor and Diane M. Simeone -- 13. Cancer Stem Cells and Renal Carcinoma / Benedetta Bussolati and Giovanni Camussi -- 14. Cancer Stem Cells: Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers / Patrizia Bottoni, Bruno Giardina, and Roberto Scatena -- 15. Cancer Stem Cells: An Innovative Therapeutic Approach / Roberto Scatena, Patrizia Bottoni, Alessandro Pontoglio, Salvatore Scarà, and Bruno Giardina -- 16. Cancer Stem Cell and ATP-Binding Cassette: Which Role in Chemoresistance? / Andrea Silvestrini, Elisabetta Meucci, Giuseppe Ettore Martorana, Bruno Giardina, and Alvaro Mordente -- 17. Stem Cells and Cancer Stem Cells: Biological and Clinical Interrelationships / Cinzia Bagalà and Carlo Barone -- 18. Immunomodulatory Functions of Cancer Stem Cells / Tobias Schatton, Jennifer Y. Lin, and Markus H. Frank.
  • This volume presents the MD Anderson experience in providing care and services to the rapidly growing population of cancer survivors, which is currently estimated to be 12 million in the United States and more than 25 million worldwide. As cancer survival rates have increased, it has slowly become clear that the challenges faced by people with cancer do not end with treatment but simply change. This book aims to assist community oncologists, physicians, and their staff, who care for the vast majority of cancer survivors, by disseminating models of surveillance for disease recurrence, screening for second primary cancers, education regarding potential late effects of treatment, and psychosocial counseling. These models have proven valuable to cancer survivors who receive care at MD Anderson.
  • Also available: Print – 2013
    Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
  • This volume is an up-to-date resource on the international state-of-the-art in the diagnosis and management of ovarian cancer. While this devastating disease has been considered mainly a disease of the Western hemisphere, the book moves beyond our conventional understanding and embraces knowledge from around the world. It focuses on recent advances in diagnosis, including genetic screening; improvements and expanded choices in management, such as gene therapy and the optimization of chemotherapeutic agents; and the latest laparoscopic and robotic surgical techniques. Further chapters address histopathologic features of this disease, and related psychosocial and quality of-life-issues. The book is aimed at the wide range of practitioners who care for patients with ovarian cancer and researchers who study the disease: general surgeons, surgical oncologists, gynecological oncologists, medical oncologists, pediatric oncologists, gynecological pathologists, gynecologists, gynecological cancer epidemiologists, gynecological onco-psychologist, genetic counselors, geneticists, and cancer research scientists.
  • Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs / Anderson T. Wang, Peter J. McHugh -- DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy? / Bernard Salles D.V.M., Ph.D. -- Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses / Moulay Alaoui-Jamali, Amine Saad, Gerald Batist -- The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy / David Murray, Matthew Parliament -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy / Jennifer J. Hu, Joseph de la Garza -- The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy / Andrew Y. Shuen, Jorge S. Reis-Filho -- DNA-PK in CLL Chemotherapy / L. Amrein, D. Davidson, R. Aloyz, L. Panasci -- Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair / Jana Krietsch, Michele Rouleau, Michel Lebel -- Cellular Protection Against the Antitumor Drug Bleomycin / Dindial Ramotar Ph.D., Mustapha Aouida Ph.D. -- ATR as a Therapeutic Target / Fiona K. Middleton, Nicola J. Curtin -- Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy / Raina A. Tamakawa, Helen B. Fleisig -- RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans / Alexander V. Mazin Ph.D., Olga M. Mazina.
  • Also available: Print – 2007
    Genome instability, checkpoints, and the cell cycle. Comparison of DNA replication in Xenopus laevis and simian virus 40 / Maren Oehlmann, Cathal Mahon, and Heinz-Peter Nasheuer. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors / P. Mathijs Voorhoeve ... [et al.] An investigation into 53BP1 complex formation / Kevin C. Roche and Noel F. Lowndes. Short abstracts--session I -- Tumor and microenvironment interactions. Tumor promotion by tumor-associated macrophages / Chiara Porta ... [et al.] The AP-2[alpha] transcription factor regulates tumor cell migration and apoptosis / Francesca Orso ... [et al.] Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation / Massimiliano Ruscica ... [et al.] Short abstracts--session II -- Animal models. The Arf tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia / Richard T. Williams and Charles J. Sherr. Short abstracts--session III -- Transcription and epigenetics. Short abstracts--session IV -- High-throughput approaches and imaging. Identification and validation of the anaplastic large cell lymphoma signature / Roberto Piva, Elisa Pellegrino, and Giorgio Inghirami. Cell-cycle inhibitor profiling by high-content analysis / Fabio Gasparri, Antonella Ciavolella, and Arturo Galvani. Short abstracts-session V -- Novel pathways and therapeutic targets. Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage / Kiyotsugu Yoshida. Short abstracts--session VI -- Poster abstracts.
  • Advances in neuroendocrine tumor management / Kjell Öberg -- Classification of digestive neuroendocrine neoplasm / Guido Rindi & Frediano Inzani -- Molecular profile and diagnosis / Christos Toumpanakis -- Surgical approach / Rossella Bettini & Massimo Falconi -- Somatostatin analogs / Wouter W. de Herder -- Combinational chemotherapy and radiotherapy / Emilio Bajetta, Emilio Bombardieri, Laura Catena, Monica Valente & Nadia Bianco -- Which therapy for which patient? / Kjell Öberg.
  • Also available: Print – 2014
    This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed nutrition and cancer from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the -omics) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions. Advances in Nutrition and Cancer will be an invaluable source of topical information for all researchers and clinicians with an interest in this field.
  • Advances in ovarian cancer management / Peter E. Schwartz -- Etiology and overview / Gang Ye, Stefanie Bernaudo & Chun Peng -- Diagnostic imaging in the management of ovarian masses / Amit Mahajan, Indukala Doddamane & Shirley McCarthy -- Initial surgical management of ovarian cancer / Jason Knight & Peter G. Rose -- Initial chemotherapy for the treatment of ovarian cancer / Katherine M. Moxley & Robert S. Mannel -- Neoadjuvant chemotherapy in the management of advanced ovarian cancer / Peter E. Schwartz -- Intraperitoneal chemotherapy : its use in epithelial ovarian cancer / Neesha Dhani & Helen Mackay -- Chemotherapeutic management of recurrent ovarian cancer / Marcia Hall -- Emerging chemotherapy agents in ovarian cancer / Daliah Tsoref & Amit M. Oza -- Surgical management of recurrent ovarian cancer / Eelco de Bree -- Angiogenesis in ovarian cancer / Vincent Castonguay & Amit M. Oza -- Antigen-specific immunotherapy for ovarian cancer / Dana M. Roque & Alessandro D. Santin -- Poly(ADP-ribose) polymerase inhibitors and epithelial ovarian cancer -- Thomas P. McNally, Gillianne G.Y. Lai & Richard T. Penson -- Emerging targeted therapies / Mirko Marabese & Massimo Broggini -- Palliative care in ovarian cancer / Cynthia O'Sullivan, Elizabeth Ercolano & Ruth McCorkle -- Guidelines in ovarian cancer / Domenica Lorusso, Antonella Pietragalla & Giovanni Scambia -- Index.
  • Advances in pancreatic cancer treatment / Helmut Friess & Norbert Hüser -- Pathophysiology of pancreatic cancer / J. Matthias Löhr, Stephan L. Haas & Rainer Heuchel -- Molecular diagnostics in pancreatic cancer / David K. Chang, Sean M. Grimmond & Andrew V. Biankin -- Surgical therapy for pancreatic cancer / Norbert Hüser, Volker Assfalg & Helmut Friess -- Multimodal treatment concepts in pancreatic cancer / Daniel Reim, Alexander Novotny & Helmut Friess -- Consensus guidelines in pancreatic cancer treatment / Wasif Saif -- Drugs in clinical trials & future directions / Zhiqiang Huang & Donald J. Buchsbaum.
  • Also available: Print – 2007
    Management of Peritoneal Surface Malignancy: A Short History / Paul H. Sugarbaker -- The Natural History of Free Cancer Cells in the Peritoneal Cavity / Yutaka Yonemura, Taiichi Kawamura, Etsurou Bandou, Gorou Tsukiyama and Yoshio Endou, et al. -- Pathological Evaluation and Implications of Serosal Involvement in Gastrointestinal Cancer / Linmarie Ludeman and Neil A. Shepherd -- Principles of Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis / Eelco de Bree and Dimitris D. Tsiftsis -- Experimental and Pharmacokinetic Studies in Intraperitoneal Chemotherapy: From Laboratory Bench to Bedside / Eelco de Bree and Dimitris D. Tsiftsis -- Technology for the Delivery of Hyperthermic Intraoperative Intraperitoneal Chemotherapy: A Survey of Techniques / Amod A. Sarnaik, Jeffrey J. Sussman, Syed A. Ahmad, Benjamin C. McIntyre and Andrew M. Lowy -- Adjuvant Intraperitoneal Chemotherapy: A Review / Paul H. Sugarbaker -- Clinical Research Methodology in Peritoneal Surface Oncology: A Difficult Challenge / François-Noël Gilly, Olivier Glehen, Annie C. Beaujard and Eddy Cotte -- Lessons Learnt from Clinical Trials in Peritoneal Surface Oncology: Colorectal Carcinomatosis / Frans A. N. Zoetmulder and Vic J. Verwaa -- Experimental Models and Questions in Basic Science Research for Pseudomyxoma Peritonei / Laura A. Lambert, Donald H. Lambert and Paul Mansfield -- Peritoneal Carcinomatosis of Colorectal Origin: Recent Advances and Future Evolution Toward a Curative Treatment / Dominique Elias and Diane Goere -- Pathologic Characterization and Differential Diagnosis of Malignant Peritoneal Mesothelioma / Nelson G. Ordóñez -- Advances in Clinical Research and Management of Diffuse Peritoneal Mesothelioma / Marcello Deraco, Dario Baratti, Nadia Zaffaroni, Antonello Domenico Cabras and Shigeki Kusamura -- Advances in the Management of Gastric Cancer with Peritoneal Dissemination / Yutaka Yonemura, Taiichi Kawamura, Etsurou Bandou, Gorou Tsukiyama and Masayuki Nemoto, et al. -- Intraperitoneal Chemotherapy in the Management of Ovarian Cancer / Maurie Markman.
  • Personalized genomic medicine: is a cancer care revolution achievable? / Dimitrios H. Roukos -- Targeting the individual cancer patient / Georgios Baltogiannis, Christos S. Katsios & Dimitrios H. Roukos -- Biomarkers-guided targeted drugs: new clinical trials design and practice necessity / Ming-Wen An, Sumithra J. Mandrekar & Daniel J. Sargent -- Personalized management for breast cancer / George C. Zografos, Dimosthenis T. Chrysikos, Paraskevi Liakou & Flora Zagouri -- Personalized management for non-small-cell lung cancer / Martin Früh, Florent Baty, Lukas Kern, Martin P. Putora & Martin Brutsche -- Personalized management for colorectal cancer / Ana Custodio & Jaime Feliu -- Successes, challenges and future directions / Stephen J. Clarke.
  • Advances in personalized therapy for lung cancer / Nagahiro Saijo -- Biomarkers in lung cancer / Tobenna Nwizu & Ravi Salgia -- EGF receptor-targeted drugs / Tetsuya Mitsudomi -- Antiangiogenic therapies for non-small-cell lung cancer / Suresh S. Ramalingam & Chandra P. Belani -- DNA-targeted drugs / Judith Meza-Junco & Michael B. Sawyer.
  • Advances in pulmonary neuroendocrine tumor management / Kjell Öberg -- Classification / Mauro Papotti -- Molecular imaging & peptide receptor radionuclide therapy / Richard P. Baum, Harshad R. Kulkarni & Dieter Hörsch -- Biotherapy : somatostatin analogs and IFN-[alpha] / Dan Granberg -- Typical and atypical bronchial carcinoid tumors / Michael Beckles, Dalvinder Mandair, Christos Toumpanakis & Martyn Caplin -- Small-cell lung cancer and large-cell neuroendocrine tumors of the lung / David Planchard & Eric Baudin -- Thymic neuroendocrine tumors / Piero Ferolla -- Algorithm for management of bronchopulmonary neuroendocrine tumors / Kjell Öberg -- Index.
  • Also available: Print – 2005
  • [1.] Non-genomic Action of Steroid Hormones: More Questions than Answers / Antimo Migliaccio, Gabriella Castoria, Antonio Bilancio, Pia Giovannelli, Marzia Di Donato and Ferdinando Auricchio -- Part I. Breast Cancer -- [2.] Progesterone Signaling to Chromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling / Guillermo P. Vicent, Roser Zaurin, Cecilia Ballaré, A. Silvina Nacht, Roni H. G. Wright, Francois Le Dily, Giancarlo Castellano, Jofre Font-Mateu and Miguel Beato -- [3.] Cooperative Interactions Between c-Src, Estrogen Receptors and Receptor Tyrosine Kinases in Breast Cancer / Sarah J. Parsons, Jessica E. Pritchard, Emily M. Fox and Margaret A. Shupnik -- [4.] Cross Talk Between ER[alpha] and Src Signaling and Its Relevance to ER Status and Hormone Responsiveness / Jun Sun, Wen Zhou, Zafar Nawaz and Joyce M. Slingerland -- [5.] Post-translational Modifications of ER Alpha in Rapid Estrogen's Action / Muriel Le Romancer, Coralie Poulard, Stéphanie Sentis, and Laura Corbo -- [6.] Sex-Steroid Rapid Action and Its Role in Invasiveness and Metastasis of Breast Cancer / Marina Ines Flamini, Angel Matias Sanchez, Xiao-Dong Fu and Tommaso Simoncini -- [7.] Unraveling the Role of GPER in Breast Cancer / Rosamaria Lappano and Marcello Maggiolini -- [8.] Nongenomic Actions of Estrogens and Xenoestrogens Affecting Endocrine Cancer Cells / Cheryl S. Watson, Dragoslava Zivadinovic, Yow-Jiun Jeng, Rebecca A. Alyea, Terumi Midoro-Horiuti, Randall Goldblum and Anannya Banga -- Part II. Prostate Cancer -- [9.] Differential Functions of Stromal and Epithelial Androgen Receptor in Prostate Cancer Before and After Castration Resistant Stage / S. Lee, K.-P. Lai, S. Yeh and C. Chang -- [10.] Role of Androgens and Androgen Receptor in Prostate Cancer: Genomic and Non-Genomic Actions / Sara Marchiani, Lara Tamburrino, Monica Muratori, Lorella Bonaccorsi, Gianni Forti and Elisabetta Baldi -- [11.] Mechanisms of Signal Transduction in Prostate Cancer: The Role of PI3-Kinase Pathway in Androgen Action / Laurent Morel and Silvère Baron -- [12.] The IGF-I Axis in Prostate Cancer: The Role of Rapid Steroid Actions / Antonino Belfiore -- Androgen Receptor Pathway in Prostate Cancer: Old Target and New Drugs / Christophe Massard and Karim Fizazi -- Part III. New Tools for Steroid Receptor Analysis and Regulatory Networks -- [13.] Quantitative Visualization of Sex Steroid Receptor Functions: AR and ER[alpha] / Michael J. Bolt, Sean M. Hartig, Adam T. Szafran, Sanjay N. Mediwala, Marco Marcelli and Michael A. Mancini -- [14.] Micropatterned Surfaces as Tools for the Study of the Rapid Non-genomic Actions of Steroid Receptors / Andrew C. B. Cato, Emmanuel Oppong and Sylwia Sekula-Neuner.
  • Dawn of a new era in molecular cancer therapeutics -- Obstacles and opportunities in the clinical development of targeted therapeutics -- Tumor models for preclinical development of targeted agents -- Angiogenesis inhibitors: what is the clinical future? -- Epidermal growth factor receptor (EGFR) inhibitors in cancer therapy -- Cell survival signaling during apoptosis: implications in drug resistance and anti-cancer therapeutic development -- Targeted histone deacetylase inhibition for cancer prevention and therapy -- Inhibitors of cyclin-dependent kinase modulators for cancer therapy -- Targeting cyclooxygenase-2 for cancer prevention and treatment -- Antisense approaches in drug discovery and development -- Preclinical development of Alimta (Pemetrexed LY231514), a multitargeted antifolate.
  • Advances in the management of triple-negative breast cancer / Tiffany A. Traina & Clifford A. Hudis -- Etiology and risk factors / Laura Fejerman & Elad Ziv -- Diagnosis and pathology / Govardhanan Nagaiah & Jame Abraham -- Molecular subtypes and emerging therapeutic opportunities / Anastasia Constantinidou, Robin L. Jones & Jorge S. Reis-Filho -- Molecular profile of triple-negative breast cancer / Leonel F. Hernandez-Aya & Ana Maria Gonzalez-Angulo -- Role of metabolic rehabilitation-based approach in TNBC : biguanide metformin and more / Lev M. Berstein, Garik A. Dashyan & Vladimir F. Semiglazov -- Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer / Mark Robson -- Targeted therapies: EGFR inhibitors / Farrah M. Datko & Maura N. Dickler -- Targeted therapies : other agents in clinical trials / Brian R. Haney, Nathan M. Shumway & George E. Peoples -- Combined therapies and future directions / Anastasia Pazaiti & Ian S. Fentiman.
  • Advances in the pathogenesis and treatment of glioblastoma multiforme / Michael Prados -- Pathogenesis, molecular characteristics and prognostic factors for survival / Keith L. Ligon -- Standard treatment approaches for newly diagnosed glioblastoma / Soon-Tae Lee & Patrick Y. Wen -- Targeted therapeutic strategies for relapsed disease / John F. de Groot & Howard Colman -- Genes, viruses, toxins and vaccines as therapeutic modalities / Tal Shahar, Manish K. Aghi & Zvi Ram -- Drug delivery strategies for glioblastoma / Pin-Yuan Chen, Dali Yin, John Forsayeth & Krystof S. Bankiewicz -- Index.
  • Advances in the treatment of B-cell chronic lymphocytic leukemia / Michael J. Keating & Constantine Tam -- Chronic lymphocytic leukemia : diagnosis and clinical staging / Stephen P. Mulligan & Constantine S. Tam -- Genetics in chronic lymphocytic leukemia / Stephan Stilgenbauer & Thorsten Zenz -- To treat or not to treat / Marco Montillo, Alessandra Tedeschi & Enrica Morra -- Chronic lymphocytic leukemia chemotherapy : two decades of progress / Carol Moreno & Emili Montserrat -- Stem cell transplantation / David G. Maloney -- Treatment options for refractory chronic lymphocytic leukemia / Marina Motta & Alessandra Ferrajoli -- Prognostic markers in chronic lymphocytic leukemia / Renata Walewska & David Oscier -- Therapeutic agents in development and future direction / Sarah Mougalian & Susan O'Brien -- Index.
  • Advances in the treatment of chronic myeloid leukemia / Giuseppe Saglio & Carmen Fava -- Diagnosis and classification of the risk / Gabriele Gugliotta, Fausto Castagnetti, Francesca Palandri, Michele Baccarani & Gianantonio Rosti -- Genetics of chronic myeloid leukemia / Giovanna Rege-Cambrin, Emilia Giugliano & Patrizia Scaravaglio -- Molecular monitoring / Martin C. Müller, Christian Dietz & Benjamin Hanfstein -- Current targeted therapy with tyrosine kinase inhibitors / Massimo Breccia & Giuliana Alimena -- Stem cell transplantation and high-dose chemotherapy / Deena Iskander, Jane F. Apperley & Jirí Pavlu -- Treatment options for tyrosine kinase inhibitor-resistant chronic myeloid leukemia / Stephan Joseph Dorkhom, Hady Ghanem & Elias Jabbour -- Prognostic factors and future direction for chronic myeloid leukemia / David Marin & Antonia Rotolo -- Chronic myeloid leukemia : the possibility of a cure / Manuel Sobrinho-Simões, David M. Ross & Junia V. Melo -- Index.
  • Also available: Print – 2011
    Roles of the TNF family in tissue homeostasis and normal development -- Novel aspects of signaling activation by the TNF family: novel aspects of the functions of the TRAFs and cIAPs -- Novel aspects of signaling activation by the TNF: ubiquitin modification of signaling proteins -- Novel aspects of signaling activation by the TNF family: TNF signaling and gene regulatory networks -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: roles of the TNF family in infectious diseases -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: interrelationship of the TNF family and pattern recognition receptor signaling -- Novel aspects of immune regulation by the TNF family -- Control of lymphocyte function and repertoire by the TNF family -- Advances in applying our knowledge to therapy: mechanisms of pathological and therapeutic effects of the TNF family -- Advances in applying our knowledge to therapy: rational design of new means for therapeutic modulation of function of the TNF family -- Roles of the TNF family in neuronal development, function, and pathology -- Cell death mechanisms controlled by the TNF family -- Contributors to abstracts of talks and posters at the 12th TNF Conference -- Abstracts of talks and posters presented at the 12th TNF Conference.
  • Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
  • Ch. 1. AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression -- Ch. 2. AEG-1/MTDH/LYRIC: clinical significance -- Ch. 3. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis -- Ch. 4. Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer -- Ch. 5. Drug resistance mediated by AEG-1/MTDH/LYRIC -- Ch. 6. The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease -- Ch. 7. AEG-1/MTDH/LYRIC in liver cancer -- Index.
  • Also available: Print – 2007
  • General information on cancer staging and end-results reporting -- Head and neck -- Digestive system -- Thorax -- Musculoskeletal sites -- Skin -- Breast -- Gynecologic sites -- Genitourinary sites -- Ophthalmic sites -- Central nervous system -- Lymphoid neoplasms -- Personnel and contributors.
  • Alcohol and cancer 2011
    The World Health Organization has identified chronic alcohol consumption as one of the top ten risk factors for worldwide burden of disease. The International Agency for Research on Cancer has identified alcohol as carcinogenic to humans, including cancers of the upper aerodigestive tract, colon, liver and breast. Alcohol{u2019}s actions may be direct e.g. effects on retinoic acid and one-carbon metabolism, or indirect, through metabolites such as acetaldehyde and reactive oxygen species or through various signaling pathways that influence cell cycle and apoptosis that may contribute to carcinogenesis. This volume reviews the state of the art in alcohol-related cancer research in ten chapters.
  • The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.
  • The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.
  • Al-Mefty's Meningiomas. 2nd ed. 2011
    Thieme eNeurosurgery
    "This new edition of Meningiomas proves a valuable contribution to the literature on the fascinating aspects of meningioma biology, diagnosis, and management"--Provided by publisher.
  • Overview of efficacy and limitation of standard and targeted therapy for malignant disease using lung cancer as a case study -- Overview of current TCM practice and potential impacts on conventional therapies -- Complementary and alternative medicine for cancer care in India: basic and clinical perspective -- Esophageal cancer -- Gastric cancer -- Colorectal cancer -- Liver cancer -- Pancreatic cancer -- Breast cancer -- Ovarian cancer -- Prostate cancer -- Kidney cancer -- Bladder cancer -- Brain cancer -- Complementary and alternative treatments for the management of cancer-related fatigue -- Complementary and alternative treatments for the management of cancer-related pain -- Challenges conducting clinical trials with herbal products in oncology -- Herbal product-drug interactions from a pharmacological perspective -- Patient-physician relationship: creating an optimal healing environment -- Legal issues in alternative treatment of cancer -- Intellectual property for alternative medicine -- Chemical-biology of natural products from medicinal plants for cancer therapy -- Flavonoids in cancer prevention and therapy: chemistry, pharmacology, mechanisms of action, and perspectives for cancer drug discovery -- Marine natural products and their synthetic derivatives for cancer therapy -- Natural product-like scaffolds for molecular dissection of macromolecular interactions and new therapeutic applications -- Mining natural product-derived molecules against cancer targets: the case of the androgen receptor in prostate cancer.
  • Analgesics for cancer pain / Tamara King & Frank Porreca -- Cancer pain assessment and consensus guidelines / Brian Wilhelmi & Paul J. Christo -- Role of step 2 opioid analgesics in mild-to-moderate pain intensity treatment / Wojciech Leppert -- Opioid analgesics for severe cancer pain / Phillip Good & Janet Hardy -- Alternative opioids and administration routes / Mellar P. Davis -- Adjuvant analgesics for cancer pain / Russell K. Portenoy & Ebtesam Ahmed -- Analgesics for breakthrough pain / Sebastiano Mercadante -- Emerging analgesics and future directions : targeting bone remodeling / Flaminia Coluzzi -- Emerging analgesics and future directions : targeting neuroplasticity / Alysia N. Lozano-Ondoua & Todd W. Vanderah -- Index.
  • The presence of oriented features in images often conveys important information about the scene or the objects contained; the analysis of oriented patterns is an important task in the general framework of image understanding. As in many other applications of computer vision, the general framework for the understanding of oriented features in images can be divided into low- and high-level analysis. In the context of the study of oriented features, low-level analysis includes the detection of oriented features in images; a measure of the local magnitude and orientation of oriented features over the entire region of analysis in the image is called the orientation field. High-level analysis relates to the discovery of patterns in the orientation field, usually by associating the structure perceived in the orientation field with a geometrical model. This book presents an analysis of several important methods for the detection of oriented features in images, and a discussion of the phase portrait method for high-level analysis of orientation fields. In order to illustrate the concepts developed throughout the book, an application is presented of the phase portrait method to computer-aided detection of architectural distortion in mammograms.
  • Androgen action and modulation of prostate and prostate cancer growth : an historical perspective / Shutsung Liao ... [et al.] -- Clinical progression to castration-recurrent prostate cancer / Mark Pomerantz and Philip Kantoff -- Differential roles of androgen receptor in prostate development and cancer progression / Shuyuan Yeh ... [et al.] -- Imaging androgen receptor function in vivo / Michael Carey and Lily Wu -- Increased expression of genes converting adrenal androgens to testosterone in castration-recurrent prostate cancer / Steven P. Balk -- Androgen-metabolic genes in prostate cancer predisposition and progression / Juergen K.V. Reichardt and Ann W. Hsing -- Effect of steroid 5[alpha]-reductase inhibitors on markers of tumor regression and proliferation in prostate cancer / Lynn N. Thomas and Roger S. Rittmaster -- 5[alpha]-reductase isozymes in castration-recurrent prostate cancer / Mark A. Titus and James L. Mohler -- Improving intermittent androgen-deprivation therapy : OFF cycle and the role of steroid 5[alpha]-reductase inhibitors / Shubham Gupta, Daniel Shevrin, and Zhou Wang -- Insights from AR gene mutations / Grant Buchanan ... [et al.] -- Functional motifs of the androgen receptor / Elizabeth M. Wilson -- The role of the androgen receptor polyglutamine tract in prostate cancer : in mice and men / Diane M. Robbins -- The androgen receptor coactivator-binding interface / Eva Estébanez-Perpiñá and Robert J. Fletterick -- Co-regulators and the regulation of androgen receptor action in prostate cancer / Irina U. Agoulnik and Nancy L. Weigel -- Androgen receptor coregulators and their role in prostate cancer / Latif A. Wafa, Robert Snoek, and Paul S. Rennie -- Interaction of the androgen receptor ligand-binding domain with the n-terminal domain and with coactivators / Jan Trapman -- Multitasking and interplay between the androgen receptor domains / F.Claessens, T. Tanner, and A. Haelens -- Chromatin remodeling and androgen receptor-mediated transcription / Li Jia ... [et al.] -- Ligand-independent androgen receptor activity / Scott M. Dehm and Donald J. Tindall -- Role of IL-6 in regulating the androgen receptor / Zoran Culig and Alfred Hobisch -- The role of cyclic AMP in regulating the androgen receptor / Marianne D. Sadar -- Cellular and molecular signatures of androgen ablation of prostate cancer / Clifford G. Tepper and Hsing-Jien Kung -- Tissue levels of androgens in castration-recurrent prostate cancer / James L. Mohler and Mark A. Titus -- Unique effects of wnt signaling on prostate cancer cells : modulation of the androgen signaling pathway by interactions of the androgen receptor gene and protein with key components of the canonical wnt signaling pathway / Matthew J. Tanner ... [et al.] -- The role of foxa proteins in the regulation of androgen receptor activity / David J. DeGraff ... [et al.] -- Androgen receptor as a licensing factor for DNA replication / Donald J. Vander Griend and John T. Isaacs -- Androgen-regulated genes in the prostate / Nigel Clegg and Peter S. Nelson -- Mapping the androgen receptor cistrome / Qianben Wang and Myles Brown -- Differential regulation of clusterin isoforms by the androgen receptor Tanya K. Day, Colleen C. Nelson, and Martin E. Gleave -- Androgen regulation of prostate cancer gene fusions / Rou Wang, Scott A. Tomlins, and Arul M. Chinnaiyan -- Androgens and the lipogenic switch in prostate cancer / Johannes V. Swinnen ... [et al.] -- Molecular biology of novel targets identified through study of castration-recurrent prostate cancer / Philip A. Watson and Charles L. Sawyers -- Selenium and androgen receptor in prostate cancer / Nagalakshmi Nadiminty and Allen C. Gao.
  • Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies. Understanding the functions of androgen-responsive genes and their regulation and deregulation in prostate cancer progression may lead to new approaches to prevent and treat prostate cancer patients. This book provides an up-to-date review of the overall androgen-responsive gene expression program and the regulation, function, and clinical relevance of both protein coding and non-coding androgen-responsive genes. Experts in the field of androgen action and prostate cancer research discussed the importance of DNA elements, chromatin structure, cellular signaling, and cell-cell interactions in the regulation of androgen-responsive genes in the context of prostate cancer progression, including the development of CRPC. This book is intended for individuals interested in cancer endocrinology and medical and healthcare professionals involved in prostate cancer research.
  • Angiopoietins / Yvonne Reiss -- HIF-1 alpha and cancer therapy / Mei Yee Koh, Tally R. Spivak-Kroizman, Garth Powis -- Chemokines / Andreas Hippe, Bernhard Homey, Anja Meuller-Homey -- Angiogenesis inhibition in cancer therapy / Iris Appelmann ... [et al.] -- Vascular integrins : therapeutic and imaging targets of tumor angiogenesis / Curzio Ruegg, Gian Carlo Alghisi -- PDGF and vessel maturation / Carina Hellberg, Arne Ostman, C.-H. Heldin -- Lymphangiogenesis in cancer : current perspectives / Rudiger Liersch ... [et al.] -- Compounds in clinical phase III and beyond / Torsten Kessler ... [et al.] -- Metronomic chemotherapy : principles and lessons learned from applications in the treatment of metastatic prostate cancer / Urban Emmenegger ... [et al.] -- Targeting inflammatory cells to improve anti-VEGF therapies in oncology / Hans-Peter Gerber, Ezogelin Olazoglu, Iqbal S. Gerwal -- Antibody-based vascular tumor targeting / Christoph Schliemann, Dario Neri -- Caveolae and cancer / Kerri A. Massey, Jan E. Schnitzer.
  • Part I: Angiogenesis in cancer -- Strategies to prolong the nonangiogenic dormant state of human cancer / George N. Naumov and Judah Folkman -- Vascular endothelial growth factor: basic biology and clinical implications / Napoleone Ferrara -- Angiogenesis in solid tumors / Rakesh K. Jain and Dan G. Duda -- Pathophysiologic role of VEGF in hematologic malignancies / Klaus Podar ... [et al.] -- Tumor microenvironment and angiogenesis / Cheryl H. Baker and Isaiah J. Fidler -- Part II: Targeting angiogenesis for cancer therapy -- Tyrosine kinase inhibitors of angiogenesis / Janessa J. Laskin and Alan B. Sandler -- Development of antiangiogenic monoclonal antibodies for cancer therapy / Zhenping Zhu and Daniel J. Hicklin -- Targeting fibroblast growth factor / fibroblast growth factor receptor system in angiogenesis / Marco Rusnati and Marco Presta -- Development of the VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and discovery of the next generation of angiogenesis targets / John S. Rudge ... [et al.] -- Proteinases and their inhibitors in angiogenesis / Yves A. DeClerck, Khalid Bajou, and Walter E. Laug -- Prostaglandins and COX-2: role in antiangiogenic therapy / Kristin Hennenfent, Daniel Morgensztern, and Ramaswamy Govindan -- Integrins, adhesion, and coadhesion inhibitors in angiogenesis / Abebe Akalu and Peter C. Brooks -- Conventional therapeutics with antiangiogenic activity / Christian Hafner, Thomas Vogt, and Albrecht Reichle -- Vascular disrupting agents / David J. Chaplin, Graeme J. Dougherty, and Dietmar W. Siemann -- Vascular and hematopoietic stem cells as targets for antiangiogenic therapy / Carlos Almeida Ramos, Hans-Georg Kopp, and Shahin Rafii -- Genetic strategies for targeting angiogenesis / Anita Tandle, Mijung Kwon, and Steven K. Libutti -- Identification of new targets using expression profiles / Thomas R. Burkard ... [et al.].; Part III: Translating angiogenesis inhibitors to the clinic -- Clinical trial design and regulatory issues / Ramzi N. Dagher and Richard Pazdur -- Surrogate markers for antiangiogenic cancer therapy / Darren W. Davis -- Noninvasive surrogates / Bruno Morgan and Mark A. Horsfield -- Pharmacodynamic markers in tissues / Darren W. Davis -- Blood-based biomarkers for VEGF inhibitors / Amado J. Zurita, Hua-Kang Wu, and John V. Heymach -- Part IV: Treatment of specific cancers with angiogenesis inhibitors -- Antiangiogenic therapy for colorectal cancer / Paulo M. Hoff and Everardo D. Saad -- Combined modality therapy of rectal cancer / Christopher G. Willett and Dan G. Duda -- Antiangiogenic therapy for breast cancer / Pablo M. Bedano ... [et al.] -- Antiangiogenic therapy for lung malignancies / David J. Stewart -- Antiangiogenic therapy for prostate cancer / Leslie K. Walker, Glenn Liu, and George Wilding -- Antiangiogenic therapy for hematologic malignancies / Karen W.L. Yee and Francis J. Giles -- Antiangiogenic therapy for gliomas / Heinrich Elinzano and Howard A. Fine -- Antiangiogenic therapy for Kaposi's sarcoma / Henry B. Koon, Liron Pantanowitz, and Bruce J. Dezube -- Antiangiogenic therapy for melanoma / Keith Dredge and Angus G. Dalgleish -- Sunitinib and renal cell carcinoma / Robert J. Motzer and Sakina Hoosen.
  • 1. Historical introduction -- 2. Modes of action -- 3. The problem of resistance -- 4. Pharmacodynamics of anti-infective agents: target delineation and susceptibility breakpoint selection -- 5. Antimicrobial agents and the kidneys -- 6. Drug interactions involving anti-infective agents -- 7. Antibiotics and the immune system -- 8. General principles of antimicrobial chemotherapy -- 9. Laboratory control of antimicrobial therapy -- 10. Principles of chemop rophylaxis -- 11. Antibiotic policies -- 12. Aminoglycosides and aminocyclitols -- 13. β-Lactam antibiotics : cephalosporins -- 14. β-Lactam antibiotics: penicillins -- 15. Other β-lactam antibiotics -- 16. Chloramphenicol and thiamphenicol -- 17. Diaminopyrimidines -- 18. Fosfomycin and fosmidomycin -- 19. Fusidanes -- 20. Glycopeptides -- 21. Lincosamides -- 22. Macrolides -- 23. Mupirocin -- 24. Nitroimidazoles -- 25. Oxazolidinones -- 26. Quinolones -- 27. Rifamycins -- 28. Streptogramins -- 29. Sulfonamides -- 30. Tetracyclines -- 31. Miscellaneous antibacterial agents -- 32. Antifungal agents -- 33. Antimycobacterial agents -- 34. Anthelmintics -- 35. Antiprotozoal agents -- 36. Antiretroviral agents -- 37. Other antiviral agents -- 38. Sepsis -- 39. Abdominal and other surgical infections -- 40. Infections associated with neutropenia and transplantation -- 41. Infections in intensive care patients -- 42. Infections associated with implanted medical devices -- 43. Antiretroviral therapy for HIV -- 44. Infections of the upper respiratory tract -- 45. Infections of the lower respiratory tract -- 46. Endocarditis -- 47. Infections of the gastrointestinal tract -- 48. Hepatitis -- 49. Skin and soft-tissue infections -- 50. Bacterial infections of the central nervous system -- 51. Viral infections of the central nervous system -- 52. Bone and joint infections -- 53. Infections of the eye -- 54. Urinary tract infections -- 55. Infections in pregnancy -- 56. Sexually transmitted diseases -- 57. Leprosy -- 58. Tuberculosis and other mycobacterial infections -- 59. Superficial and mucocutaneous mycoses -- 60. Systemic fungal infections -- 61. Zoonoses -- 62. Malaria -- 63. Other protozoal infections -- 64. Helminthic infections.
  • Antibody-drug conjugates 2013
    Springer Protocols
    Antibody-drug conjugate (ADC) clinical pipeline : a review / Ingrid Sassoon and Veronique Blanc -- Antibody-drug conjugate target selection : critical factors / Neil H. Bander -- Selecting an optimal antibody for antibody-drug conjugate therapy : internalization and intracellular localization / Jay Harper ... [et al.] -- Antibody-drug conjugate payloads / Jan Anderl ... [et al.] -- Linker technologies for antibody-drug conjugates / Birte Nolting -- In vivo testing of drug-linker stability / Pierre-Yves Abecassis and Celine Amara -- Pharmacokinetics and ADME characterizations of antibody-drug conjugates / Kedan Lin, Jay Tibbitts, and Ben-Quan Shen -- Safe handling of cytotoxic compounds in a biopharmaceutical environment / Miriam I. Hensgen and Bernhard Stump -- Micro- and mid-scale maleimide-based conjugation of cytotoxic drugs to antibody hinge region thiols for tumor targeting / James E. Stefano ... [et al.] -- Protocols for lysine conjugation / Marie-Priscille Brun and Laurence Gauzy-Lazo -- Engineering THIOMABs for site-specific conjugation of thiol-reactive linkers / Sunil Bhakta, Helga Raab, and Jagath R. Junutula -- Enzymatic antibody modification by bacterial transglutaminase / Patrick Dennler, Roger Schibli, and Eliane Fischer -- Formulation development of antibody-drug conjugates / William J. Galush and Aditya A. Wakankar -- Conjugation process development and scale-up / Bernhard Stump and Jessica Steinmann -- Methods for conjugating antibodies to nanocarriers / Anil Wagh and Benedict Law -- Drug-to-antibody ratio (DAR) by UV/Vis spectroscopy / Yan Chen -- Drug-to-antibody ratio (DAR) and drug load distribution by hydrophobic interaction chromatography and reversed phase high-performance liquid chromatography / Jun Ouyang -- Drug-to-antibody ratio (DAR) and drug load distribution by LC-ESI-MS / Louisette Basa -- Determination of charge heterogeneity and level of unconjugated antibody by imaged cIEF / Joyce Lin and Alexandru C. Lazar -- Risk-based scientific approach for determination of extractables/leachables from biomanufacturing of antibody-drug conjugates (ADCs) / Weibing Ding.
  • This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.
  • The concept of delivering 'magic bullets' to treat diseases was first proposed by Paul Erlich in the early 1900's. The realization of this concept for the treatment of cancer occurred in the late 1990's with the approval of monoclonal antibody therapies. The use of monoclonal antibodies conjugated (linked) to potent cytotoxic agents (antibody-drug conjugates, ADCs) for specifically delivering cytotoxics to cancer cells was an obvious extension of antibody-based therapy. ADCs have been under intense investigation for several decades; progress, however, has been limited due to toxicity or lack of improved efficacy compared to unconjugated cytotoxics. More recently, linker technology and target selection have advanced such that several ADCs and immunotoxins are undergoing clinical testing or are approved for use. This important volume gives the latest and most comprehensive information on the topic, describing different types of ADCs and immunotoxins for both hematologic and solid malignancies. Finally, the volume highlights the promise that this technology holds for diverse types of human cancer.
  • "This book covers clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. The second edition includes drugs that are currently in development. In addition, the text emphasizes the applications of synthetic and medicinal chemistry to the preparation of analogs with enhanced activities. Contributors also address the potential of novel drug discovery through the use of genome mining as well as the status of advanced development candidates. For each compound of class of compounds, the text provides information on the history, structure, mechanism of action, development, synthesis, medicinal chemistry, and clinical applications"-- Provided by publisher. "The search for new lead compounds is a crucial element of modern pharmaceutical research. Natural products provided the only source of pharmaceuticals for thousands of years, and natural products have made enormous contributions to human health through compounds such as quinine, morphine, aspirin (a natural product analog), digitoxin, and many others. The potential of natural products as anticancer agents was recognized in the 1950's by the U. S. National Cancer Institute (NCI) under the leadership of the late Dr. Jonathan Hartwell, and the NCI has since made major contributions to the discovery of new naturally occurring anticancer agents through its contract and grant support, including an important program of plant and marine collections. Many, although not all, of the compound classes described in the following pages owe their origin in whole or in part to NCI support. In spite of the success of the natural products approach to anticancer drug discovery, as exemplified by the following chapters, in recent years their importance as a source of molecular diversity for drug discovery research and development has been overshadowed by newer chemical approaches currently in favor. These approaches include chemical ones which make heavy use of combinatorial chemistry, and biological ones such as manipulation of biosynthetic pathways of microbial metabolites through combinatorial biosynthetic techniques. It is thus worthwhile to review briefly the major reasons why natural products are so important. First, there is a strong biological and ecological rationale for plants and marine invertebrates to produce novel bioactive secondary metabolites"-- Provided by publisher.
  • Anticancer genes 2014
    Also available: Print – 2014
    "This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as "Anticancer Genes", are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells."--Publisher's website.
  • History of drug discovery : early evaluation studies and lessons learnt from them / Ahmad, Z., Makaya, N.H. and Grosset, J. -- Tuberculosis treatment trials past and present : old and new challenges / Nunn, N. -- The rifamycins : renewed interest in an old drug class / Burman, W., Dooley, K.E., and Nuermberger, E. -- Isoniazid pharmacokinetics and efficacy in adults and children / Donald, P.R. and Schaaf, H.S. -- Recent developments in the study of pyrazinamide : an update / Mitchison, D.A. and Zhang, Y. -- Experience with phase III clinical trials of antituberculosis drugs and regimens : conclusions and lessons for the future / Jindani, A. -- Tuberculosis recurrence : exogenous or endogenous? / Williams, M. ... [et al.] -- Second-line antituberculosis drugs : current knowledge, recent research findings and controversies / Schaaf, H.S., Seddon, J.A., and Caminero, J.A. -- Acquisition, transmission, and amplification of drug-resistant tuberculosis / Müller, B. ... [et al.] -- The treatment of tuberculosis in children -- Cruz, A.T. and Starke, J.R. -- Issues and challenges in the development of novel tuberculosis drug regimens / Erondu, N. and Ginsberg, A. -- Drug resistance in mycobacterium tuberculosis : molecular mechanisms and laboratory susceptibility testing / Bittger, E.C. -- The role of the mouse model in the evaluation of new antituberculosis drugs / Nuermberger, E.L. -- Current issues in tuberculosis pharmacokinetics / Egelund, E.F. and Peloquin, C.A. -- Pharmacological considerations of antitubercular agents in children / Goldman, J.L., Kearns, G.L., and Abdel-Rahman, S.M. -- Interactions between antituberculosis and antiretroviral agents / Mcilleron, H. and Khoo, S.H. -- Diabetes mellitus and tuberculosis treatment / Ruslami, R., Van Crevel, R. -- Early bactericidal activity of antituberculosis agents / Maritz, J.Z., Diacon, A.H., and Donald, P.R. -- Assessment of whole-blood bactericidal activity in the evaluation of new antituberculosis drugs / Wallis, R.S. -- Serial sputum colony counting in drug regimens / Sloan, D. and Davies, G. -- The evaluation of new antituberculosis drugs in children / Mcneeley, D.F. ... [et al.] -- A new era in tuberculosis treatment : what does the future hold? / Duncan, K.
  • Evaluation and decision making for metastatic spine tumors / Yan Michael Li, Michael S. Dirks, Claudio E. Tatsui, and Laurence D. Rhines -- Neoplastic spinal instability / Daryl R. Fourney and Charles G. Fisher -- Major complications associated with stereotactic ablative radiotherapy (SABR) for spinal metastasis / Simon S. Lo, Arjun Sahgal, and Eric L. Chang -- En bloc resection in the treatment of spinal metastases : technique and indications / Ilya Laufer, Jean-Paul Wolinksy, and Mark H. Bilsky -- Region specific approaches / Daniel Sciubba -- Spinal reconstruction and fixation/fusion / Rajiv Saigal and Dean Chou -- Minimally invasive surgery for metastatic spine disease / Meic H. Schmidt -- Vertebral augmentation for metastatic disease / Ehud Mendel, Eric Bourekas, and Paul Porensky -- Surgical complications and avoidance / Michelle J. Clarke.
  • Evaluation and decision making / Stefano Boriani and Charles Fisher -- Safety and efficacy of surgery for primary tumors of the spine / Daryl R. Fourney, Charles Fisher, and Stefano Boriani -- Interventional options for primary tumors / Sudhir Kathuria -- Radiation therapy for primary bone tumors / Brent Y. Kimball and Yoshiya Yamada -- Medical oncology principles for the spine oncology surgeon / Scott H. Okuno, Steven Robinson and Shreyaskumar Patel -- Spinal osteoid osteoma and osteoblastoma / Melissa Nadeau and Christian DiPaola -- ABC, giant cell / Stefano Boriani, Stefano Bandiera, Riccardo Ghermandi, Simone Colangeli, Luca Amendola, and Alessandro Gasbarrini -- Chordoma / Jackson Sui, Patricia L. Zadnik, Mari L. Groves, and Ziya L. Gokaslan -- Chondrosarcoma / Stefano Boriani, Stefano Bandiera, Riccardo Ghermandi, Simone Colangeli, Luca Amendola, and Alessandro Gasbarrini -- Osteogenic and ewing sarcomas of the spine / Derek G. Ju, Patricia L. Zadnik, and Daniel M. Sciubba -- Margins in spine tumor resection : how much is enough? is planned -- Transgression okay? / Ilya Laufer, Mari Groves, and Jean-Paul Wolinsky -- Principles behind determining the right approach / Nicolas Dea and Rowan Schouten -- Spino-pelvic reconstruction/fixation and fusion / Peter Paul Varga -- Structural graft selection and wound closure techniques -- Complications and avoidance: how to plan primary tumor resection to minimize complications and maximize outcome / Michael C. Oh, Vedat Deviren, and Christopher P. Ames.
  • APC proteins 2009
    Also available: Print – 2009
    APC and [beta]-catenin degradation -- Nuclear APC -- APC in cell migration -- The APC-EB1 interaction -- The role of APC in mitosis and in chromosome instability -- Role of APC and its binding partners in regulating microtubules in mitosis -- The adenomatous polyposis coli tumor -- Suppressor and Wnt signaling in the regulation of apoptosis -- APC and its modifiers in colon cancer -- Tissue-specific tumour suppression by APC -- Extra-colonic manifestations of familial adenomatous polyposis coli.
  • Modulation of apoptosis to reverse chemoresistance / Gil Mor, Michele K. Montagna, and Ayesha B. Alvero - - Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis / Suparna Mazumder, Dragos Plesca, and Alexandru Almasan - - Flow cytometry enumeration of apoptotic cancer cells by apoptotic rate / David Diaz ... [et al.] - - Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection / Dan-Arin Silasi ... [et al.] - - Flow cytometric detection of activated caspase-3 / Richard Fox and Martine Aubert - - The chemofx® assay : an ex vivo chemosensitivity and resistance assay for predicting patient response to cancer chemotherapy / Stacey L. Brower, Jeffrey E. Fensterer, and Jason E. Bush -- Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines / Ayesha B. Alvero, Michele K. Montagna, and Gil Mor - - Assessing expression of apoptotic markers using large cohort tissue microarrays / Elah Pick, Mary M. McCarthy, and Harriet M. Kluger -- Mitochondria potential, bax "activation," and programmed cell death / C. Michael Knudson and Nicholas M. Brown -- In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases / Brian W. Lee ... [et al.] - - Caspase activity assays / Andrew L. Niles, Richard A. Moravec, and Terry L. Riss - - Multiplex caspase activity and cytotoxicity assays / Andrew L. Niles, Richard A. Moravec, and Terry L. Riss - - Homogeneous, bioluminescent proteasome assays / Martha A. O'Brien ... [et al.] - - A simple method for profiling mirna expression / Jia-Wang Wang and Jin Q. Cheng - - Apoptotic caspase activation and activity / Jean-Bernard Denault and Guy S. Salvesen - - Biochemical analysis of the native trail death-inducing signaling complex / Henning Walczak and Tobias L. Haas - - Laser microdissection sample preparation for RNA analyses / Christopher J. Vega.
  • v. 2, 2007 Springer
    BCR-ABL and human cancer / Maria Pérez-Caro and Isidro Sánchez-Garcia -- Angiogenesis and cancer / Yohei Maeshima -- Metastasis: the evasion of apoptosis / Christine E. Horak ... [et al.] -- Carcinogenesis: balance between apoptosis and survival pathways / Dean G. Tang and James P. Kehrer -- Aberrations of DNA damage checkpoints in cancer / Marikki Laiho -- c-Myc, apoptosis, and disordered tissue growth / Michael Khan and Stella Pelengaris -- Role of lysophospholipids in cell growth and survival / Xianjun Fang and Sarah Spiegel -- Alternative use of signaling by the [beta] GBP cytokine in cell growth and cancer control: from surveillance to therapy / Livio Mallucci and Valerie Wells -- Control nodes linking the regulatory networks of the cell cycle and apoptosis / Baltazar D. Aguda, Wee Kheng Yio, and Felicia Ng -- Regulation of NF-[kapa]B function: target for drug development / Daniel Sliva and Rakesh Srivastava -- 5-fluorouracil: molecular mechanisms of cell death / Daniel B. Longley and Patrick G. Johnston -- Apoptosis-inducing cellular vehicles for cancer gene therapy: endothelial and neural progenitors / Gergely Jarmy ... [et al.] -- Apoptosis and cancer therapy / Maurice Reimann and Clemens A. Schmitt -- Coupling apoptosis and cell division control in cancer: the survivin paradigm / Dario C. Altieri -- Clinical significance of histone deacetylase inhibitors in cancer / Sharmila Shankar and Rakesh K. Srivastava.
  • The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy.
  • Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various -omics technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.
  • Ch. 1. Cancer terminator viruses and approaches for enhancing therapeutic outcomes -- Ch. 2. Adenovirus strategies for tissue-specific targeting -- Ch. 3. Syrian hamster as an animal model to study oncolytic adenoviruses and to evaluate the efficacy of antiviral compounds -- Ch. 4. Design of improved oncolytic adenoviruses -- Ch. 5. The development of transcription-regulated adenoviral vectors with high cancer-selective imaging capabilities -- Ch. 6. Adenovirus-based immunotherapy of cancer, promises to keep -- Ch. 7. Cancer treatment with gene therapy and radiation therapy -- Ch. 8. Oncolytic adenoviruses for cancer immunotherapy, data from mice, hamsters, and humans -- Index.
  • Array comparative genomic hybridization : an overview of protocols, applications, and technology trends / Diponkar Banerjee -- Ultradense array CGH and discovery of micro-copy number alterations and gene fusions in the cancer genome / Ewa Przybytkowski [and others] -- Epigenomics : sequencing the methylome / Martin Hirst -- Application of array comparative genomic hybridization in chronic myeloid leukemia / Seonyang Park [and others] -- Use of cytogenetic microarrays in myelodysplastic syndrome Characterization / Lisa G. Shaffer, Blake C. Ballif, and Roger A. Schultz -- CGH protocols : chronic lymphocytic leukemia / Esteban Braggio, Rafael Fonseca, and Neil E. Kay -- Analysis of Acquired genomic copy number aberrations and regions of loss of heterozygosity in acute myelogenous leukemia genomes using affymetrix SNP 6.0 arrays and supporting software tools / Peter D. Ouillette [and others] -- Clinical applications of BAC array-CGH to the study of diffuse large B-cell lymphomas / Cristina Robledo, Juan Luis Garcia, and Jesus M. Hernandez -- Genomic profiling of mantle cell lymphoma / Melissa Rieger Menanteau and Jose A. Martinez-Climent -- Copy number analysis in EBV-positive nodal peripheral T cell lymphoma, unspecified / Kyusam Choi, Hyunjeong Ju, and Young Hyeh Ko -- Mycosis fungoides and Sezary syndrome / Blanca Espinet and Rocio Salgado -- Array CGH reveals clonal evolution of adult T-cell leukemia/lymphoma / Akira Umino and Masao Seto -- Array-CGH analysis of cutaneous anaplastic large cell lymphoma / K. Szuhai [and others] -- Genome-wide DNA profiling of HIV-related B-cell lymphomas / Andrea Rinaldi [and others] -- Array comparative genomic hybridization in osteosarcoma / Bekim Sadikovic [and others] -- Comparative genomic hybridization of Wilms' tumor / Shahrad Rod Rassekh and Evica Rajcan-Separovic -- Array-CGH in childhood MDS / Marcel Tauscher, Inka Praulich, and Doris Steinemann -- Nonfamilial breast cancer subtypes / Markus Ringner, Johan Staaf, and Goran Jonsson -- Applications of array-CGH for lung cancer / Kenneth J. Craddock, Wan L. Lam, and Ming-Sound Tsao -- Array CGH in brain tumors / Gayatry Mohapatra, Julia Sharma, and Stephen Yip -- Finding common regions of alteration in copy number data / Oscar M. Rueda, Ramon Diaz-Uriarte, and Carlos Caldas -- Distinguishing somatic and germline copy number events in cancer patient DNA hybridized to whole-genome SNP genotyping arrays / Gavin Ha and Sohrab Shah.
  • Atlas of Brain and Spine Oncology Imaging presents a comprehensive visual review of pathologic disease variations of cancers of the brain and spine through extensive radiologic images. The focus of the book is on algorithmic strategies for identifying neoplastic pathologies commonly found in brain and spinal tumors through a visual representation of the variety of appearances that each neoplasm takes, within both benign and malignant manifestations.
  • Back Cover Text Breast reconstructive and oncoplastic surgery can reduce the sense of mutilation resulting from oncologic surgery and meets the need to provide breast cancer treatment that will not only eradicate the cancer but also re-establish the patient?s quality of life. However, the difficulties inherent in preoperative planning and the intraoperative complexity of breast reconstruction and oncoplastic techniques represent major challenges for the breast surgeon. This atlas, intended for surgeons at every level, is an all-inclusive guide that documents surgical techniques step by step by means of a wealth of more than 1000 color photos, additional high-quality drawings and illustrations, and succinct accompanying text. Both common, established procedures and the most recently introduced techniques are covered, ensuring that readers will have at their disposal multiple approaches for breast repair, remodeling, and reconstruction. In addition to the comprehensive descriptions of techniques, preoperative planning is explained, indications and contraindications are identified, and the management of surgical complications is discussed. Tips, pitfalls, and key points are highlighted. The Atlas of Breast Reconstruction is an unprecedented tool that will increase and refine the arsenal at the oncoplastic surgeon's disposal in order to ensure that the best treatment can be offered to each individual patient.
  • Atlas of breast surgery 2015
  • Aspiration of a breast cyst -- Incision and drainage of an abscess -- Ultrasound-guided percutaneous excisional biopsy -- Stereotactic breast biopsy -- Breast ductoscopy -- Excisional breast biopsy of palpable or nonpalpable lesions -- Needle localization breast biopsy -- Radioisotope occult lesion localization -- Cryoablation-assisted lumpectomy -- Excision followed by radiofrequency ablation -- Axillary sentinel lymph node biopsy -- Mediastinal sentinel lymph node biopsy -- Axillary lymph node dissection -- Axillary reverse mapping -- Simple mastectomy -- Simple extended and modified radical mastectomy -- Oncoplastic approaches to the partial mastectomy for breast conservation therapy -- Breast reconstruction postmastectomy with tissue expanders and alloderm -- Tissue breast reconstruction -- Utility of reduction mammoplasty techniques in oncoplastic surgery -- Chest wall resection -- Forequarter amputation -- Mammosite balloon catheter placement and other brachytherapy delivery devices -- In vivo intraoperative radiation therapy for breast cancer -- Targeted intraoperative radiation therapy (TARGIT).
  • Also available: Print – 2008
  • Clear cell carcinoma (CCC) of the ovary with its unique clinical and biological features has attracted great attention, and calls for the publication of a specialized book on the subject. This is the first atlas that has narrowed its focus to CCC. Revealed here are the typical and variable histological features of CCC and related tumors. Hundreds of high-quality photographs help the reader to recognize the pathological features and clinical manifestations of CCC and to formulate diagnoses confidently and accurately. Data are based on the international central pathological review of the JGOG/GCIG3017 clinical trial in which experts around the world participated. Using a virtual slide system, interesting and significant features of CCC were discovered in the review of 652 cases. This book provides the newest information on the categorization and classification of CCC: growth patterns (papillary, tubocystic, solid, and adenofibromatous), cell types (classical hobnail and clear cell, eosinophilic, oxyphilic, and oncocytic), stromal changes (hyalinized, necrotic, hemorrhagic, lymphocytic infiltrative, luteinized, and psammomatous calcification), presence of endometriosis and atypical endometriosis, and borderline/atypical proliferative tumors. The Atlas of Clear Cell Carcinoma of the Ovary is an invaluable diagnostic resource for pathologists and gynecologic oncologists.
  • Introduction -- Benign Focal Liver Lesions -- Malignant Focal Liver Lesions -- Fatty Liver, Pseudolesions -- Other Rare Lesions -- Assessment of Therapy Response -- Impact of European Guidelines on CEUS.
  • The integration of clinical findings, laboratory results, and disease progression is critical for the diagnosis and treatment of patients with skin lymphoma. This atlas includes numerous clinical and histological images with diagrams, tables, and text describing each type of lymphoma in the current cutaneous classification scheme, which includes information on the recent classification scheme for cutaneous lymphoma published by the World Health Organization and the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Group. Atlas of Cutaneous Lymphomas: Classification and Differential Diagnosis includes chapters on synonyms, clinical features (presentation, prognosis, and treatment), laboratory findings (histopathology, immunophenotype, and molecular), differential diagnosis, and presentation of clinical cases for each diagnostic entity. In addition, chapters are included on T-cell lymphomas, B-cell lymphomas, ancillary techniques including immunohistochemistry and molecular tests, and a glossary of terms. This book will help clarify the classification of cutaneous lymphoma and will serve as a useful tool for physicians involved in the diagnosis and treatment of patients with cutaneous lymphoma.
  • The role of molecular probes and other markers in the diagnosis of malignancy / Tad Wieczorek and Janina A. Longtine -- Radiographic evaluation of cancer / Kitt Shaffer -- Nuclear medicine in oncology / Steven Burrell and Annick van den Abbeele -- Cancer of the head and neck region / Robert Haddad ... [et al.] -- Lung cancer and tumors of the heart and mediastinum / Ravi Salgia, Ramon Blanco and Arthur T. Skarin -- Malignant mesothelioma / Pasi A. Janne, David Wu and Lucian R. Chirieac -- Cancer of the gastrointestinal tract and neuroendocrine tumors / Jeffrey A. Meyerhardt, Matthew Kulke and Jerrold R. Turner -- Cancer of the genitourinary tract / William K. Oh ... [et al.] -- Gynecologic tumors and malignancies / Michelle S. Hirsch, Karen J. Krag and Ursula A. Matulonis -- Breast cancer / Wendy Y. Chen, Susana M. Campos and Daniel F. Hayes -- Endocrine neoplasia / Peter M. Sadow, Mark A. Socinski and Francis D. Moore, Jr. -- Sarcomas of soft tissue and bone and gastrointestinal stromal tumors / Susan George ... [et al.] -- Skin cancer / Philip Friedlander ... [et al.] -- Neoplasms of the central nervous system / Elizabeth A. Maher and Ann C. McKee -- Acute and chronic leukemias / Martha Wadleigh, David M. Dorfman and Arthur T. Skarin -- Hodgkin disease and non-Hodgkin lymphomas / Eric Jacobsen, David M. Dorfman and Arthur T. Skarin -- Multiple myeloma and plasma cell dyscrasias / Noopur Raje ... [et al.] -- Solid tumors in childhood / Stephan D. Voss ... [et al.] -- AIDS-associated malignancies / Jeremy S. Abramson and David T. Scadden -- Complications of cancer / Nadine Jackson McCleary and Arthur T. Skarin -- Systemic and mucocutaneous reactions to chemotherapy / Joseph P. Eder and Arthur T. Skarin.
  • Diagnostic Techniques in Gastrointestinal Disease -- Device and Equipment for Endoscopic Therapy -- Endoscopic Mucosal Resection (EMR) -- Endoscopic Submucosal Dissection (ESD) -- Endoscopic Resection for Submucosal Tumors -- Tunnel Endoscopic Surgery.
  • This book covers all of the diagnostic areas where FNAC is used today. This includes palpable lesions and lesions sampled using various radiological methods, and correlations with ancillary examinations detailed on an entity-by-entity basis. As well as being a complete atlas of the facts and findings important to FNAC, this atlas is a guide to diagnostic methods that optimize health care. The interaction of the cytologist or cytopathologist with other specialists (radiologists, oncologists and surgeons) involved in the diagnosis and treatment of patients with suspicious mass lesions is emphasized and illustrated throughout. ? With contributions from experts in the field internationally and abundant colour images Atlas of Fine Needle Aspiration Cytology provides a comprehensive and up-to-date guide to FNAC for pathologists, cytopathologists, radiologists, oncologists, surgeons and others involved in the diagnosis and treatment of patients with suspicious mass lesions.
  • The Atlas of Genitourinary Oncological Imaging presents a comprehensive visual review of appearances for normal anatomy and oncological diseases in the genitourinary system using over 900 radiological images and illustrations. The book presents current imaging techniques and discusses the role of imaging in pre-treatment staging and post-treatment follow-up. Diseases discussed include kidney, adrenal gland, upper tract, bladder, prostate, testes, and pediatric malignancies. Individual chapters include normal anatomy, imaging techniques, and pathology of each cancer type. The staging of the malignancy and what to include in the radiology report are discussed, and expected and complicated postoperative and post-treatment findings and recurrence are presented. Dedicated chapters on interventional and radiation therapy discuss their unique role in the management and treatment of oncology of the genitourinary system. Additionally, a chapter on chemotherapy toxicities discusses drug reaction treatment therapies unique to the genitourinary system.Edited and written by radiologists from the genitourinary disease management team at Memorial Sloan-Kettering Cancer Center, the Atlas of Genitourinary Oncological Imaging is an ideal resource for radiology and urology trainees seeking a review of the basics and for practicing radiologists looking for answers to challenging cases confronted in daily practice.
  • This book provides a comprehensive visual review of pathologic disease variations of the five main types of gynecologic cancers: ovarian, endometrial, cervical, vaginal, and vulvar. Through the use of cross-sectional imaging modalities, including computed tomography, magnetic resonance imaging, ultrasound, and positron emission tomography, it depicts normal anatomy as well as common gynecological tumors. For each type of cancer, aspects such as primary staging, recurrence patterns, and findings from different yet complementary imaging modalities are explored. Atlas of Gynecologic Oncology Imaging presents a coherent perspective of the roles of standard and cutting-edge imaging techniques in gynecologic oncology via a multidisciplinary approach to cancer care. Featuring over 600 images, this book is a valuable resource for diagnostic radiologists, radiation oncologists, and gynecologists.
  • Surgery for head neck cancer has evolved greatly in the recent years. Appropriate surgical resection with negative margins still remain corner-stone in achieving good oncological outcome. This atlas proposes a new concept of " The Compartment Surgery " to achieve negative margins in third dimensions which is the problem area in majority of cases. Reconstructive techniques have evolved vastly in the recent years with use of microvascular free flaps and this has significantly improved the functional outcome. Performing each step in appropriate manner cumulatively enables us to perform more complex procedures. Theme of this atlas revolves around this fact. This atlas on head and neck cancers takes a fresh stylistic approach where each surgical procedure is described in a step-wise manner through labeled high-resolution images with minimal incorporation of text. This allows the surgeons to rapidly revise the operative steps of a procedure within minutes just before they start a surgery. Head and neck has multidimensional anatomy and surgical treatment requires specific approach for each subsite. This operative atlas covers the entire spectrum of common, uncommon and rare cancers of the head and neck area. Each subsite is addressed in a separate chapter with further subdivisions for surgery of tumors with varying extent. Each procedure is demonstrated with photographs of each surgical step and line diagrams. Commonly used flaps (regional and free flaps) are demonstrated in separate chapter for reconstruction. With over 1000 images, and coverage of both the ablative and reconstructive surgical procedures, this is a technique-focused atlas in comparison to the available comprehensive texts. There are two chapters on very advanced cancers, and surgery in resource constrained surgical units making the book relevant to a wide range of cancer surgeons and fellows-in-training in varied clinical settings.
  • Male genital disorders represent a common issue in medical practice, especially in the dermatological setting. Correct clinical evaluation of these disorders is essential when addressing the diagnosis, which in some cases may require histopathological confirmation. Depending on the disease, early diagnosis may be not only lifesaving, but also of fundamental importance to the planning of successful treatment. This atlas introduces the most common penile diseases, along with more rarely encountered ones. It provides invaluable guidance on clinical diagnosis by highlighting prominent clinical features and presenting particular videodermatoscopy findings when these are indicative of the diagnosis. In addition, for each condition the most appropriate treatment is proposed, taking into account recent therapeutic advances of proven benefit.
  • Also available: Print – 2007
    Anatomy of the breast -- Techniques and positioning in mammography -- An approach to mammographic analysis -- Circumscribed masses -- Indistinct and spiculated masses -- Analysis of calcification -- Prominent ductal patterns -- Asymmetry and architectural distortion -- The thickened skin pattern -- The axilla -- The male breast -- The postsurgical breast -- The augmented breast -- Galactography -- Needle localization -- Percutaneous breast biopsy -- The roles of ultrasound and magnetic resonance imaging in breast imaging.
  • This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a multidisciplinary perspective, highlighting pertinent clinical, radiological, and histological correlations. Treatment is briefly reported for each entity. In addition, the more recent biomolecular findings of use for diagnosis, prognosis, and treatment are carefully analyzed. The Rizzoli case archive spans more than a century, the first treated case dating back to 28 September 1900, and contains the original material, clinical charts, imaging, paraffin blocks, and histological slides of more than 40,000 cases, including about 29,000 bone lesions and 11,000 soft tissue lesions. This book reports the most relevant entities and reflects the improvements in knowledge of musculoskeletal tumors as presented during the yearly international course held at the Rizzoli Institute.
  • Lymphangiomatosis -- Pleuropulmonary blastoma -- Congenital pulmonary myofibroblastic tumor -- Alveolar adenoma -- Uncommon endobronchial surface tumors -- Mucous gland adenoma -- Pleomorphic adenoma -- Mucoepidermoid tumor -- Adenoid cystic carcinoma -- Inflammatory polyps -- Inflammatory pseudotumor -- Pulmonary chondroma -- Pulmonary hamartoma -- Localized fibrous tumor -- Lipomas and liposarcomas -- Cystic lymphangioma -- Lymphangioleiomyomatosis -- Epithelioid hemangioendothelioma -- Pulmonary artery sarcoma -- Synovial sarcoma -- Marginal zone B-cell lymphoma (maltoma) -- Diffuse large B-cell lymphoma -- Lymphomatoid granulomatosis -- Langerhans cell histiocytosis -- Typical and atypical carcinoids -- Teratoma -- Melanoma -- Thymoma -- Glomus tumor of the lung -- Sclerosing hemangioma -- Preinvasive disease -- Squamous cell carcinoma -- Adenocarcinoma -- Large cell carcinoma -- Small cell carcinoma -- Adenosquamous carcinoma -- Bronchioloalveolar carcinoma -- Large cell neuroendocrine carcinoma -- Sarcomatoid carcinoma -- Pulmonary blastoma -- Metastatic tumors.
  • Surgical Technique in Cancer Surgery -- Intraoperative Lymphatic Mapping/Sentinel Lymphadenectomy -- Tumor in the Hand -- Tumor in the Wrist -- Tumor in the Ventral Aspect of the Forearm -- Tumor in the Dorsal Aspect of the Forearm -- Tumor in the Anterior Compartment of the Arm -- Tumor in the Dorsal Aspect of the Arm -- Tumor in the Medial Arm -- Axillary Node Dissection -- In Continuity Axillary and Supraclavicular Node Dissection -- Neck Dissection -- Tumor at the Shoulder Point -- Tumor in the Neck -- Scapulectomy -- Shoulder Disarticulation -- Forequarter Amputation -- Tumor in the Back -- Chest Wall Tumors -- Tumor in the Lower Chest Wall and Upper Abdomen -- Involvement of the Abdominal Wall by Tumor -- One-Layer Closure of the Abdominal Wall -- Midline Abdominal Wall Gaps and Incisional Hernia -- Regional Chemotherapy Infusion Via the Hepatic Artery -- Peritoneolysis in the Reconstruction of a Roux-en-Y Loop -- Hilar Hepatojejunostomy -- Hepatic Resection -- Pancreaticoduodenectomy -- Distal Pancreatectomy -- Colonic Interposition for Esophageal Replacement -- Ileal Loop Bladder-Interposition Conduit -- Resection of Mesenteric Tumors -- Dissection in the Bowel Mesentery and Its Clinical Applications -- Retroperitoneal Node Dissection -- Retroperitoneal Sarcomas -- Tumor in the Lesser Sac -- Tumor in the Right Abdomen -- Tumor in the Left Abdomen -- The T or L Incision in Resection of Tumors of the Pelvis -- Groin Dissection -- Abdominoinguinal Incision in the Resection of Pelvic Tumors and Limb Salvage -- Resection of Pelvic Tumors with Visceral Involvement -- Internal Hemipelvectomy -- The Surgical Importance of the Inferior Epigastric Vessels -- Sacral Resection -- Tumor in the Buttock Area -- Tumor in the Anterior Thigh -- Tumor in the Medial Thigh -- Tumor in the Posterior Thigh -- Popliteal Node Dissection -- Tumor in the Leg -- Tumor in the Foot -- Hip Disarticulation -- Hemipelvectomy (Hindquarter Amputation) -- Variants of Hemipelvectomy -- Central Venous Access -- Resection of Tumors of the Ischiorectal Fossa.
  • Part 1. Pilocytic astrocytoma and Pilomyxoid Astrocytoma -- Pilocytic astrocytoma and Pilomyxoid Astrocytoma / Christine Fuller and Sonia Narendra -- Pleomorphic Xanthoastrocytoma / Christine E. Fuller -- Infiltrative Astrocytomas (Diffuse Astrocytoma, Anaplastic Astrocytoma, Glioblastoma) / Christine E. Fuller -- Oligodendroglial Tumors / Christine E. Fuller -- Ependymal Tumors / Christine E. Fuller, Sonia Narendra and Ioana Tolicica -- Introduction and Overview of Brain Tumors / Adekunle M. Adesina -- Part 2. Embryonal Neuroepithelial Tumors -- Central Nervous System Primitive Neuroectodermal Tumors and Medulloepithelioma / Adekunle M. Adesina, J. Hunter and L. Rorke-Adams -- Medulloblastoma / Adekunle M. Adesina and J. Hunter -- Atypical Teratoid Rhabdoid Tumor / Adekunle M. Adesina, J. Hunter and L. Rorke-Adams -- Part 3. Tumors of the Meninges -- Meningiomas / Christine Fuller and Brian Pavlovitz -- Hemangiopericytoma and Other Mesenchymal Tumors / Christine E. Fuller -- Melanocytic Lesions / Christine E. Fuller -- Hemangioblastoma -- Christine E. Fuller -- Part 4. Tumors of Cranial and Spinal Nerves -- Schwannoma / Tarik Tihan -- Neurofibroma / Tarik Tihan -- Malignant Peripheral Nerve Sheath Tumors / Tarik Tihan -- Part 5. Neuronal and Mixed Neuronal-glial Tumors -- Desmoplastic Infantile Astrocytoma and Ganglioglioma / Adekunle M. Adesina -- Dysembryoplastic Neuroepithelial Tumor / Adekunle M. Adesina and Ronald A. Rauch -- Ganglioglioma and Gangliocytoma / Adekunle M. Adesina and Ronald A. Rauch -- Central Neurocytoma and Extraventricular Neurocytoma / Adekunle M. Adesina and Ronald A. Rauch -- Papillary Glioneuronal Tumor / M. Rivera-Zengotita, A. Illner and Adekunle M. Adesina -- Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle / M. Rivera-Zengotita and Adekunle M. Adesina -- Malignant Epithelioid Glioneuronal Tumor / M. Rivera-Zengotita, R. Rauch and Adekunle M. Adesina -- Paraganglioma / A. Rivera and Adekunle M. Adesina -- Part 6. Neurocutaneous Syndromes -- Neurofibromatosis 1 / Tarik Tihan -- Neurofibromatosis 2 / Tarik Tihan -- Von Hippel-Lindau Disease / Tarik Tihan and Adekunle M. Adesina -- Tuberous Sclerosis Complex / Tarik Tihan and Adekunle M. Adesina -- L'hermitte-Duclos Disease and Cowden Disease / T. Hidehiro, S. Hiroyoshi and Adekunle M. Adesina -- Part 7. Tumors in the Region of the Pituitary Fossa -- Pituitary Tumors / Tarik Tihan and Christine E. Fuller -- Craniopharyngioma / Tarik Tihan -- Part 8. Choroid Plexus Neoplasms -- Choroid Plexus Neoplasms / Christine E. Fuller, Sonia Narendra and Ioana Tolocica -- Part 9. Pineal Based Tumors -- Pineal Parenchymal Tumors / Tarik Tihan -- Part 10. Germ Cell Tumors -- Germ Cell Tumors / Tarik Tihan -- Part 11. Paraneoplastic Disorders -- Paraneoplastic Disorders of the Central Nervous System / Christine E. Fuller and Sonia Narendra -- Part 12. Tumours of the Haematopoietic System -- Malignant Lymphoma / Adekunle M. Adesina -- Histiocytic Tumors / A. Mukherjee and Adekunle M. Adesina -- Part 13. Interesting/Challenging Cases and Exercises in Pattern Recognition -- Case Studies / Adekunle M. Adesina, Christine E. Fuller and Lucy Rocke-Adams.
  • This new project on PET/MR imaging in oncology includes digital interactive software matching the cases in the book. The interactive version of the atlas is based on the latest web standard, HTML5, ensuring compatibility with any computer operating system as well as a dedicated version for Apple iPad and iPhone. The book opens with an introduction to the principles of hybrid imaging that pays particular attention to PET/MR imaging and standard PET/MR acquisition protocols. A wide range of illustrated clinical case reports are then presented. Each case study includes a short clinical history, findings, and teaching points, followed by illustrations, legends, and comments. The multimedia version of the book includes dynamic movies that allow the reader to browse through series of rotating 3D images (MIP or volume rendered), display blending between PET and MR, and dynamic visualization of 3D image volumes. The movies can be played either continuously or sequentially for better exploration of sets of images. The editors of this state-of-the-art publication are key opinion leaders in the field of multimodality imaging. Professor Osman Ratib (Geneva) and Professor Markus Schwaiger (Munich) were the first in Europe to initiate the clinical adoption of PET/MR imaging. Professor Thomas Beyer (Zurich) is an internationally renowned pioneering physicist in the field of hybrid imaging. Individual clinical cases presented in this book are co-authored by leading international radiologists and nuclear physicians experts in the use of PET and MRI.
  • 1. How to Use This Atlas -- 2. Normal Skin -- 3. Basal Cell Carcinoma -- 4. Infiltrative Basal Cell Carcinoma -- 5. Differentiating Basal Cell Carcinoma from Normal and Benign Histologic Findings -- 6. Adnexal Tumors -- 7. Microcystic Adnexal Carcinoma -- 8. Differentiating Infiltrative Basal Cell Carcinoma from Other Tumors -- 9. Squamous Cell Carcinoma In Situ and Actinic Keratoses -- 10. Squamous Cell Carcinoma -- 11. Differentiating Squamous Cell Carcinoma from other entities -- 12. Dermatofibrosarcoma Protuberans -- 13. Other Non-melanocytic Skin Cancer -- 14. Pitfalls and Incidental Findings -- 15. Artifacts.
  • The incidence of skin cancer has risen rapidly in recent decades, and patients often present initially to practitioners in many different specialties. Because skin cancer can vary in clinical appearance, even dermatologists may experience difficulty in reaching a clinical diagnosis. For primary care physicians and physician extenders (physician assistants, nurses, and nurse practitioners), who have had very little or no formal training in dermatology, the task can be still more daunting. In this atlas, the authors set out to provide a practical resource that will help improve the 'visual vocabulary' of physicians and physician extenders, helping them identify lesions that should be biopsied.--Abstract (excerpt).
  • Soft tissue tumors are a large and heterogeneous group of tumors and pseudotumors with a spectrum of behavior from benign to frankly malignant. This Atlas of Soft Tissue Tumor Pathology provides an overview of reactive, pseudoneoplastic, benign and intermediate neoplasms, sarcomas and related conditions arising in subcutaneous and deep soft tissues. Emphasis is placed on microscopic appearances with correlation with gross diagnostic findings where relevant. In addition, the immunohistochemical and molecular genetic features of the major soft tissue tumor subtypes are presented.
  • Physical and technical essentials -- Ultrasound features of thyroid lesions -- Nodular or colloid goiter, hyperplasia, and cysts -- Follicular adenoma and follicular thyroid carcinoma -- Oncocytic nodule/Hurtle cell tumors -- Follicular variant of papillary thyroid carcinoma -- Papillary thyroid carcinoma -- Medullary thyroid carcinoma -- Anaplastic carcinoma -- Lymphoma and plasmacytoma -- Thyroiditis -- Metastases -- Regional lymph node metastases.
  • This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.
  • Bacteria and cancer 2012
  • Radiation physics -- Radiobiology -- Clinical radiation oncology -- Central nervous system tumors -- Head and neck cancers -- Lung cancer -- Breast cancer -- Genitourinary system cancers -- Gynecological cancers -- Gastrointestinal system cancers -- Soft tissue sarcoma -- Skin cancer -- Lymphomas and total body irradiation.
  • Basics of oncology 2009
  • Also available: Print – 2010
    Homeostatic functions of BCL-2 proteins beyond apoptosis / Nika N. Danial, Alfredo Gimenez-Cassina, and Daniel Tondera -- Alternative functions of the BCL-2 protein family at the endoplasmic reticulum / Diego Rojas-Rivera ... [et al.] -- BH3-only proteins and their effects on cancer / Thanh-Trang Vo and Anthony Letai -- Endoplasmic reticulum stress and BCL-2 family members / Ross T. Weston and Hamsa Puthalakath -- Targeting survival pathways in lymphoma / Luca Paoluzzi and Owen A. O'Connor -- The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis / Maria Eugenia Soriano and Luca Scorrano -- Noncanonical functions of BCL-2 proteins in the nervous system / Heather M. Lamb and J. Marie Hardwick -- Mitochondria on guard : role of mitochondrial fusion and fission in the regulation of apoptosis / Mariusz Karbowski.
  • Diagnosis of benign tumors of the liver is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph opens by examining the epidemiology, histopathology, and genetics of these diseases and discussing liver physiopathology. The role of imaging techniques is described, and clear guidance provided on differential diagnosis. The full range of benign liver tumors and conditions is then systematically reviewed, including liver cysts and polycystic liver disease, Caroli disease, hemangiomas, focal nodular hyperplasia, adenomas, hepatic manifestations of systemic diseases, and focal infectious diseases. Surgical indications are accurately analyzed, with a view to assisting in the avoidance of useless interventions. Transplantation, laparoscopic resection, and robotic surgical techniques are described and illustrated, emphasizing the optimization of intra- and postoperative management in order to avoid potential complications and degeneration. In these chapters, attention is drawn to the ways in which the surgical management of benign liver tumors differs from that of malignant tumors. Information is also provided on anesthesia, blood transfusion, the role of interventional radiology in patients with benign liver tumors and fast track programs for liver surgery. This book, in handy format, will prove essential reading for all who are interested in benign liver surgery and will represent an invaluable source of knowledge for general and hepatobiliary surgeons, whether in training or practice.
  • Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.
  • Head and neck cancer -- Non-small cell lung cancer -- Small cell lung cancer -- Esophageal cancer -- Gastric cancers -- Biliary tract cancers -- Primary cancers of the liver -- Colorectal cancer -- Pancreatic cancer -- Anal cancer -- Other gastrointestinal tumors -- Breast cancer -- Renal cell cancer -- Prostate cancer -- Bladder cancer -- Testicular carcinoma -- Ovarian cancer -- Endometrial cancer -- Cervical cancer -- Vulvar cancer -- Sarcomas and malignancies of the bone -- Skin cancers and melanoma -- Acute leukemia -- Chronic lymphoid leukemias -- Chronic myeloid leukemia -- Chronic myeloproliferative neoplasms -- Multiple myeloma -- Non-Hodgkin lymphoma -- Hodgkin lymphoma -- Hematopoietic cell transplantation -- Carcinoma of unknown primary -- Central nervous system tumors -- Endocrine tumors -- Hematopoietic growth factors -- Infectious complications in oncology -- Oncologic emergencies and paraneoplastic syndromes -- Psychopharmacologic management in oncology -- Management of emesis -- Medical nutrition therapy -- Pain and palliative care -- Central venous access device -- Procedures in medical oncology -- Diagnosis-driven individualization of cancer care -- Basic principles of radiation oncology -- Clinical genetics -- Anticancer agents.
  • Sect. 1. Head and neck. Head and neck cancer / Barbara A. Conley ... [et al.] -- Sect. 2. Thorax. Non-small cell lung cancer / Anne M. Horgan and Oscar S. Breathnach -- Small cell lung cancer / Neelima Denduluri and Martin E. Gutierrez -- Sect. 3. Digestive system. Esophageal cancer / Gregory D. Leonard, David P. Kelsen, and Carmen J. Allegra -- Gastric cancer / M. Wasif Saif -- Biliary tract cancer / Gregory D. Leonard, Eileen M. O'Reilly, and Carmen J. Allegra -- Primary cancers of the liver / Gregory D. Leonard, William R. Jarnagin, and Carmen J. Allegra -- Colorectal cancer / George P. Kim, Chris H. Takimoto, and Carmen J. Allegra -- Pancreatic cancer / George P. Kim, James L. Gulley, Chris H. Takimoto -- Anal cancer / M. Wasif Saif -- Other gastrointestinal tumors / M. Wasif Saif -- Sect. 4. Breast. Breast cancer / Hamid R. Mirshahidi and Jame Abraham -- Sect. 5. Genitourinary. Renal cell cancer / Hung T. Khong, Christopher Klebanoff, and Susan Bates -- Prostate cancer / James L. Gulley and William L. Dahut -- Bladder cancer / Manish Agarwal and William L. Dahut -- Testicular carcinoma / Avi S. Retter and Barnett S. Kramer -- Sect. 6. Gynecologic. Ovarian cancer / Eddie Reed and Ramin Altaha -- Endometrial cancer / Christina M. Annunziasta and Michael J. Birrer -- Cervical cancer / Edwin M. Posades and Herbert L. Kotz -- Vulvar cancer / Christina M. Annunziasta and Michael J. Birrer -- Sect. 7. Musculoskeletal. Sarcomas and malignancies of the bone / Patrick J. Mansky and Lee Helman -- Sect. 8. Skin cancer. Skin cancers and melanoma / Upendra P. Hegde and Barry Gause -- Sect. 9. Hematologic malignancies. Acute leukemias / Michael Craig, Jame Abraham, and Brian P. Monahan -- Chronic leukemias / Muzaffar H. Quazilbash and Michael J. Keating -- Chronic myeloid leukemia / Muzaffar H. Quazilbash and Jorge E. Cortes -- Myeloproliferative diseases / Manish Monga and Marcel P. Devetten -- Multiple myeloma / Sattva S. Neelapu and Cynthia E. Dunbar -- Non-Hodgkin lymphoma / Martin Gutierrez, Richard F. Little, and Wyndham H. Wilson -- Hodgkin lymphoma / Gisa Schun, Jame Abraham, and Marcel P. Devetten -- Hematopoietic stem cell transplantation / Michael Craig, Jame Abraham, and Richard W. Childs -- Sect. 10. Other malignancies. Acquired immunodeficiency syndrome-related malignancies / Pallavi P. Kumar and Richard F. Little -- Carcinoma of unknown primary / Hung T. Khong -- Central nervous system tumors / Patrick J. Mansky, J. Paul Duic, and Howard A. Fine -- Endocrine tumors / Michael E. Menefee and Tito Fojo -- Sect. 11. Supportive care. Hematopoietic growth factors / Philip M. Arlen and James L. Gulley -- Infectious complications in oncology / Sarah M. Wynne and Juan C. Gea-Banacloche -- General principles of cancer pain management / Jason R. Beckrow and Richard A. Messmann -- Oncologic emergencies and paraneoplastic syndromes / Muhammad K. Siddique and Richard A. Messmann -- Psychopharmacologic management in oncology / Donald L. Rosenstein, Maryland Pao, and June Cai -- Management of emesis in oncology / David R. Kohler -- Nutrition for oncology patients / Marnie Dobbin -- End-of-life care / Jane Carter -- Sect. 12. Targeted treatments and complimentary and alternative medicine. Targeted therapies / James L. Gulley and Gregory Curt -- Complementary and alternative medicine in oncology / Patrick J. Mansky, Dawn b. Wallerstedt, and Marc R. Blackman -- Sect. 13. Common procedures and chemotherapy drugs. Central venous access devices / Deborah C. Gutierrez and Naomi P. O'Grady -- Procedures in medical oncology / Suzanne G. Demko and Kerry Ryan -- Anticancer agents / Thomas E. Hughes.
  • The second edition of this book is intended as a definitive text on biliary tract and gallbladder cancers. Specifically, it will serve as a single-source reference on the current knowledge base for the multidisciplinary management of such cancers and thus covers epidemiological, surgical, radiotherapy, and chemotherapy approaches. Akey feature is the demonstration of the impact of cutting-edge technical knowledge on treatment; for example, interventional radiology techniques, novel surgical approaches, and image-guided radiation therapy are all extensively discussed. Diagnosis is also considered in detail, with coverage of novel serum biomarkers, pathologic staging, molecular profiling, and the full range of current and emerging imaging strategies. Further chapters are devoted to epidemiology, the role of growth factor pathways and signal transduction, and histopathology and molecular pathogenesis. Experienced practitioners in a range of specialties will find this amply illustrated book to be an invaluable source of information on the newest diagnostic and treatment techniques in biliary tract and gallbladder cancer, yet it is also sufficiently concise to offer an introduction to the field for students and community practitioners.
  • Monitoring the burden of cancer in the United States -- Cancer biology and nutrigenomics -- Cellular cancer processes and their molecular targets -- Nutrigenetics: the relevance of polymorphisms -- Diet and epigenetics -- Nutrient signaling-protein kinase to transcriptional activation -- Dietary energy balance, calorie restriction, and cancer prevention -- Fiber and microbially generated active components -- Gut microbiota, probiotics, prebiotics and colorectal cancer -- Meats, protein and cancer -- Saturated fatty acids and cancer -- Conjugated linoleic acid and cancer -- Cancer and n-3PUFAs: the translational connection -- n-6 polyunsaturated fatty acids and cancer -- Carotenoids -- Vitamin A -- Vitamin D and cancer chemoprevention -- Folate -- Selenium -- Calcium and cancer -- Iron and cancer -- Zinc in cancer development and prevention -- Cruciferous vegetables, isothiocyanates, indoles, and cancer prevention -- Garlic and cancer prevention -- Mammary and prostate cancer chemoprevention and mechanisms of action of resveratrol and genistein in rodent models -- Cancer prevention by catechins, flavonols, and procyanidins -- Mechanisms of action of isoflavones in cancer prevention -- The anticarcinogenic properties of culinary herbs and spices -- Cancer prevention with berries: role of athocyanins -- Pomegranate -- Alcohol and cancer: biological basis -- Aryl hydrocarbon receptor-mediated carcinogenesis and modulation by dietary xenobiotic and natural ligands -- Opportunities and challenges for communicating food and health relationships to American consumers.
  • The emergence of bioinformatics : historical perspective, quick overview and future trends / Christos A. Ouzounis -- The statistical design and interpretation of microarray experiments / Kevin K. Dobbin and Richard M. Simon -- Whole-genome analysis of cancer / Steven A. Enkemann ... [et al.] -- Bioinformatics approaches to the analysis of the transcriptome of animal models of cancer / Mark J. Hoenerhoff ... [et al.] -- Significance of aberrant expression of miRNAs in cancer cells / George A. Calin ... [et al.] -- Proteomic methods in cancer research / Scot Weinberger and Egisto Boschetti -- Comprehensive genomic profiling for biomarker discovery for cancer detection, diagnostics and prognostics / Xiaofeng Zhou ... [et al.] -- Gene expression profiling of the leukemias : oncogenesis, drug responsiveness, and prediction of clinical outcome / Lars Bullinger, Hartmut Dohner, and Jonathon R. Pollack -- Personalized medicine in the clinical management of colorectal cancer / Anthony El-Khoueiry and Heinz Josef Lenz -- PIK3CA gene alterations in human cancers / Sérgia Velho, Carla Oliveira, and Raquel Seruca.
  • Also available: Print – 2015
    In recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements.
  • Also available: Print – 2005
  • "Cancer is a class of disease or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues. One new approach in dealing with cancer is through apoptotic regulators, which is the process of controlling cell growth by abnormally prolonging cell survival, facilitating the accumulation of transforming mutations and promoting resistance. This book uses oral cancers as the specific means to demonstrate this technique with this particular type of cancer, which is quite prevalent (and deadly) in India and other parts of Asia, in particular"--Provided by publisher.
  • Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon -- Analytical aspects of biomarker immunoassays in cancer research / C. G. J. (Fred) Sweep, Chris M. G. Thomas and Manfred Schmitt -- Tissue microarrays: state-of-the-art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik -- Gene expression profiling with DNA microarrays / Michele De Bortoli and Nicoletta Biglia -- Assays for gene amplification / Chungyeul Kim, Yongkuk Song, and Soonmyung Paik -- Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori -- Urokinase-type plasminogen activator and PAI-1 / Michael J. Duffy -- Predictive value of c-erbb-2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns -- Erb-b-2 as a therapeutic target / Robert Mass -- The epidermal growth factor receptor pathway as a selective -- Molecular-targeting treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora -- P-53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz -- Occult metastatic cells in breast cancer patients / Stephan Braun, Julia Seeber, and Christian Marth -- Circulating HER-2/neu / Allan Lipton ... [et al.] -- Circulating vascular endothelial growth factor / Roberta Sarmiento ... [et al] -- Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote -- New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini -- Index.
  • Biosensors and cancer 2013
    Functional optical imaging-based biosensors / Pablo Iglesias and Jose A. Costoya -- Use of a surface plasmon resonance (SPR) biosensor to characterize zwitterionic coatings on SiO2 for cancer biomarker detection / Norman D. Brault, Shaoyi Jiang, and Qiuming Yu -- Microcantilever-based biosensor array for tumor angiogenic marker detection / Riccardo Castagna and Carlo Ricciardi -- Electrochemical DNA biosensors at the nanoscale / Rosa Letizia Zaffino ... [et al.] -- Aptamer-based biosensors for cancer studies / Ilaria Palchetti and Marco Mascini -- Fluorescent biosensors for cancer cell imaging and diagnostics / May C. Morris -- Electrical and electrochemical immunosensor for cancer study / Seung Yong Lee and Seung Yong Hwang -- Multifunctional nanobiosensors for cancer / Dai-Wen Pang and Er-Qun Song -- Silicon nanowire biosensor for cancer markers / Yang-Kyu Choi and Chang-Hoon Kim -- DNA-electrochemical biosensors and oxidative damage to DNA : application to cancer / Victor Constantin Diculescu and Ana Maria Oliveira Brett -- Asparaginase-based asparagine biosensors and their application to leukemia / Neelam Verma and Kuldeep Kumar -- Breast cancer detection using surface plasmon resonance-based biosensors / Chii-Wann Lin and Chia-Chen Chang -- Detection of miRNA with silicon nanowire biosensors / Guo-Jun Zhang -- Biosensors for BCR-ABL activity and their application to cancer / Yusuke Ohba ... [et al.] -- Optical fiber nanobiosensor for single living cell detections of cancers / Xin Ting Zheng and Chang Ming Li -- Microfluidic biosensors for thyroglobulin detection and application to thyroid cancer / Seokheun Choi and Junseok Chae -- Optical biosensors and applications to drug discovery and development in cancer research / Carlo Bertucci and Angela De Simone -- Single-chain fragment variable recombinant antibodies and their applications in biosensors for cancer diagnosis / Xiangqun Zeng and Ray Mernaugh -- DNA biosensor for rapid detection of anticancer drugs / Sigen Wang and Ruili Wang -- Using UV light to engineer biosensors for cancer detection : the case of prostate specific antigen / Maria Teresa Neves-Petersen, Antonietta Parracino, and Steffen B. Petersen.
  • Biologicals' Characteristics / K. Ho and J.-H. Trouvin -- From the Biosimilar Concept to the Marketing Authorisation / M. Pavlovic and J.-L. Prugnaud -- Immunogenicity / J.-L. Prugnaud -- Substitution and Interchangeability / J.-L. Prugnaud -- G-CSFs: Onco-Hematologist's Point of View / D. Kamioner -- The Oncologist's Point of View / C. Chouaïd -- Biosimilars: Challenges Raised by Biosimilars: Who is Responsible for Cost and Risk Management? / F. Megerlin.
  • Central Nervous System Tumors / Paolo Aloisi, Francesco Martella, Davide Cerone and Giampiero Porzio -- Head and Neck Tumours / Keith D. Hunter and Robert Bolt -- Thyroid Cancer / Laura D. Locati, Angela Greco, Maria Grazia Borrello, Maria Luisa Carcangiu and Paolo Bossi, et al. -- Targeted Therapies for Non-small-Cell Lung Cancer / Giulio Metro and Lucio Crinò -- Non-Hodgkin's Lymphomas / Roberta Zappasodi and Massimo Di Nicola -- Leukemias / Lia Ginaldi and Massimo De Martinis -- Breast Cancer / Nadia Rucci, Luca Ventura and Anna Teti -- Oesophago-Gastric Cancer / Alex M. Reece-Smith, Simon L. Parsons and Sue A. Watson -- Colorectal Cancer / David N. Church, Rachel Susannah Midgley and David J. Kerr -- Hepatocellular Carcinoma / Yasunori Minami and Masatoshi Kudo -- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma / Laura S. Schmidt -- Bladder Cancer / Andrea Tubaro, Daniele Santini, Cosimo De Nunzio, Alice Zoccoli and Michele Iuliano -- Biomarkers in Prostate Cancer / Mauro Bologna and Carlo Vicentini -- Ovarian Cancer / Jessica Wangui Oribabor, Allison Ambrosio, Cesar M. Castro and Michael J. Birrer -- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer / Annekathryn Goodman, Leslie S. Bradford and Leslie A. Garrett -- Biotargets in Sarcomas: The Past, Present, and a Look into the Future / Vivek Subbiah and Razelle Kurzrock -- Melanoma and Other Skin Cancers / Kim H. T. Paraiso, Jobin K. John and Keiran S. M. Smalley -- Molecular Pathology of Cancer Metastasis: Suggestions for Future Therapy / Adriano Angelucci and Edoardo Alesse -- Current and Future Developments in Cancer Therapy Research: miRNAs as New Promising Targets or Tools / Marilena V. Iorio, Patrizia Casalini, Claudia Piovan, Luca Braccioli and Elda Tagliabue.
  • Bone and cancer 2009
  • Bone and Soft Tissue Pathology: A Volume in the Diagnostic Pathology Series, by Andrew L. Folpe, MD and Carrie Y. Inwards, MD, packs today's most essential bone and soft tissue pathology know-how into a compact, high-yield format! The book's pragmatic, well-organized approach, complemented by abundant full-color, high-quality illustrations and at-a-glance tables, makes it easy to access the information you need to quickly and accurately identify pathology specimens. Best of all, Expert Consult functionality provides online access to the full text of the book, downloadable illustrations for your personal use, and more. The result is a practical, affordable reference for study and review as well as for everyday clinical practice. Includes access to the complete contents online, fully searchable, downloadable illustrations for your personal use, and more, allowing you to consult the text a quick, convenient manner. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations ... making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentation and accessibility of the material. Offers nearly 1,000 full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens.
  • Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone: bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer -- Deregulation of osteoblast differentiation in primary bone cancers -- Contribution of osteoclasts to the bone: tumor niche -- Involvement of osteocytes in cancer bone niche -- Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis -- Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma -- Macrophages and pathophysiology of bone cancers -- Cytokines and bone cancers -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Bone remodeling markers and bone cancer -- Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas -- Homeobox genes from the Dlx family and bone cancers -- MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors -- Hypoxia and angiogenesis: from primary tumor to bone metastasis -- Modeling osteosarcoma: in vitro and in vivo approaches -- Stemness markers of osteosarcoma -- Molecular pathology of osteosarcoma -- Gene and proteomic profiling of osteosarcoma -- Ewing sarcoma family of tumors -- Biology of Ewing sarcoma -- Osteoclast-rich lesions of bone: a clinical and molecular overview -- Markers for bone sarcomas -- Margins and bone tumors: what are we talking about? -- Cytogenetics of bone tumors -- Genetic aspects of bone tumors -- Cytogenetic and molecular genetic alterations in bone tumors -- Genetics of giant cell tumors of bone -- Mammalian models of bone sarcomas -- Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos -- Imaging of bone sarcomas -- New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials -- Therapeutic approaches for bone sarcomas -- Chondrosarcoma of bone: diagnosis and therapy -- Apoptosis and drug resistance in malignant bone tumors -- Giant cell tumors of bone -- EMT process in bone metastasis -- Histopathology of skeletal metastases -- Disseminated tumor cells in bone marrow of cancer patients -- MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton -- Myeloma and osteoclast relationship -- In vivo models used in studies of bone metastases -- Interventional radiologic techniques in management of bone tumors -- Diagnosis of bone metastases in urological malignancies : an update -- Pre-clinical molecular imaging of "the seed and the soil" in bone metastasis -- Mechanisms and management of bone cancer pain -- Bone cancer: current opinion in palliative care -- Involvement of sympathetic nerves in bone metastasis -- Pain control with palliative radiotherapy in patients with bone metastases -- Cellular and molecular actions of bisphosphonates -- The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood [gamma delta] T cells for the treatment of bone cancer metastasis -- Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC): pre-clinical to clinical point of view -- A multi-targeted approach to treating bone metastases -- Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions -- Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases -- Bone metastases : current status of bone-targeted treatments -- Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases.
  • Chapter 1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases / Esther I. Hauben, Pancras C.W. Hogendoorn -- Chapter 2. Tumor-Bone Cell Interactions in Bone Metastases / Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise -- Chapter 3. Early Bone Metastasis-Associated Molecular and Cellular Events / Philippe Clézardin -- Chapter 4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways / Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard J. Murrills, Peter V.N. Bodine -- Chapter 5. Osteoclast Differentiation and Function / Luis Filgueira -- Chapter 6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease / Maria Grano, Giacomina Brunetti, Silvia Colucci -- Chapter 7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation / Blandine Ruhin, Frédéric Lézot, Aymann Bouattour, Sonia Ghoul-Mazgar, Ariane Berdal, Vianney Descroix -- Chapter 8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer / Frédéric Blanchard, Emmanuelle David, Bénédicte Brounais -- Chapter 9. Proteases and Therapeutic Approaches of Bone Tumors / Velasco C. Ruiz, Y. Fortun, D. Heymann, M. Padrines -- Chapter 10. Bone Remodeling Markers and Bone Cancer / Markus J. Seibel -- Chapter 11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors / Suvi Savola, Tom Böhling, Sakari Knuutila -- Chapter 12. Cytogenetics of Bone Tumors / Jiyun Lee, Mallory Martin, Shibo Li -- Chapter 13. Genetic Aspects of Bone Tumors / Shamini Selvarajah, Maria Zielenska, Jeremy A. Squire, Paul C. Park -- Chapter 14. Proteomics of Bone Cancer / Stephanie Byrum, Eric R. Siegel, Sudeepa Bhattacharyya, Larry J. Suva -- Chapter 15. Genomic and Proteomic Profiling of Osteosarcoma / Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau -- Chapter 16. Molecular Pathology of Osteosarcoma / Walter C. Bell, Gene P. Siegal -- Chapter 17. Technical Aspects: How Do We Best Prepare Bone Samples for Proper Histological Analysis? / Daniel Chappard -- Chapter 18. Osteoclast-rich Lesions of Bone: A Clinical and Molecular Overview / Adrienne M. Flanagan, Roberto Tirabosco, Panagiotis D. Gikas -- Chapter 19. Recent Advances in the Biology of Bone Tumors and New Diagnostic Tools / Gonzague de Pinieux, Corinne Bouvier -- Chapter 20. Ewing's Sarcoma Family of Tumors / Joseph D. Khoury -- Chapter 21. The Histopathology of Skeletal Metastases / Ping Tang, David G. Hicks -- Chapter 22. Interventional Radiologic Techniques and their Contribution to the Management of Bone Tumors / Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk -- Chapter 23. Imaging of Bone Metastases / Nieroshan Rajarubendra, Nathan Lawrentschuk -- Chapter 24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers / Holger Schirrmeister, Coskun Arslandemir -- Chapter 25. Pain Control with Palliative Radiotherapy in Bone Metastases / Alysa Fairchild, Amanda Hird, Edward Chow -- Chapter 26. Mechanisms and Management of Bone Cancer Pain / Ma'ann C. Sabino, Denis R. Clohisy -- Chapter 27. Malignant Skeletal Pain: Mechanisms and Potential Therapeutic Opportunities / Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan, Patrick W. Mantyh -- Chapter 28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches / Julie Rousseau, François Lamoureux, Gaëlle Picarda, François Gouin, Valérie Trichet, Françoise Rédini -- Chapter 29. In vivo Models Used in Studies of Bone Metastases / Ingunn Holen, Michelle A. Lawson -- Chapter 30. Cytokine Gene Therapy in Bone Remodeling / Carl D. Richards, David Smyth -- Chapter 31. Non-surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives / Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, Mario Mercuri -- Chapter 32. Mechanistic Role of RANKL in Cancer-induced Bone Diseases and Development of a Targeted Therapy to Inhibit this Pathway / William C. Dougall -- Chapter 33. Chondrosarcoma of Bone: Diagnosis and Therapy / Arne Streitbuerger, Jendrik Hardes, Georg Gosheger -- Chapter 34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends / Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann -- Chapter 35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer / Alexander H.G.Paterson -- Chapter 36. A Multi-targeted Approach to Treating Bone Metastases / Robert D. Loberg, Kenneth J. Pienta -- Chapter 37. Bone Metastases of Prostatic Cancer: Pathophysiology, Clinical Complications, Actual Treatment and Future Directions / Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold -- Chapter 38. Apoptosis and Drug Resistance in Malignant Bone Tumors / Udo Kontny.
  • 1. New Insights in the Development of Human B Lymphocytes / Bianca Blom -- 2. The Aging Lymphocyte / Hector F. Valenzuela, Rita B. Effros -- 3. The Bone Marrow Microenvironment and Its Impact in Acute and Chronic B Cell Malignancies / Jan A. Burger -- 4. The Expanding Diagnostic Role of Flow Cytometry in Bone Marrow Studies of Patients with Lymphomas and Plasma Cell Disorders / Anna Porwit -- 5. The Application of Molecular Techniques on Bone Marrow Trephines / Falko Fend, Leticia Quintanilla-Martínez -- 6. Residual Disease Assessment and Its Role in Monitoring Lymphoid and Plasma Cell Neoplasms / Konnie M. Hebeda -- 7. Reporting of Bone Marrow Lymphoid Infiltrates / Yi-Hua Chen, LoAnn Peterson -- 8. Janus-Faced Lymphoid Infiltrates / Dimitra Anagnostou -- 9. Singularities in Pediatric Bone Marrow Lymphoid Processes / Sophia L. Yohe, Robert W. McKenna -- 10. Bone Marrow Involvement in Primary Mature B and T Cell Leukemias / Ayoma D. Attygalle -- 11. A Step Forward in the Diagnosis of B-Cell Lymphomas in the Bone Marrow / Ahmet Dogan, Mine Hekimgil -- 12. New Insights in Waldenström's Macroglobulinemia / Meletios A. Dimopoulos, Evangelos Terpos -- 13. Bone Marrow in Hodgkin Lymphoma and Mimickers / Stefano A. Pileri, Elena Sabattini -- 14. Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas / Philippe Gaulard, Sylvia Hoeller -- 15. Systemic Mastocytosis Associated with Lymphoproliferative Disorders (SM-AHNMD) / Hans-Peter Horny, Karl Sotlar, Peter Valent.
  • Focusing on the field of metastatic bone disease, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, and, deals with various aspects of imaging modalities applied for the detection and evaluation of bone metastases.
  • The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
  • Also available: Print – 2005
    Overview / Sadmeet Singh and Gurmit Singh -- Parathyroid hormone-related peptide and malignancy / David Goltzman -- Vitamin D and vitamin D analogs in cancer / Richard Kremer and Shafaat A. Rabbani -- Role of TGF and IGF in tumor progression and bone metastases / Erin Giles and Gurmit Singh -- Biologic and therapeutic implications of osteomimicry and epithelial/mesenchymal transition in prostate cancer / Wen-Chin Huang, Valerie Odero-Marah, and Leland W.K. Chung -- The roles of immune-cell derived matrix metalloproteinases in tumor growth and metastasis / Kristina A. Szabo and Gurmit Singh -- Contribution of osteopontin to the development of bone metastasis / Alison L. Allan ... [et al.] -- The role of interleukin-11 in osteolytic bone metastasis / Ryan R. Simon ... [et al.] -- Cell adhesion moleculars in tumor metastasis / Sujata Persad ... [et al.] -- Antithrombotics in tumor growth and metastasis / Shaker A. Mousa -- Challenges and strategies in the analysis of multiple events in oncology / Pierre P. Major and Richard J. Cook -- Integrins : novel targets for the treatment of bone metastasis / Graham C. Parry ... [et al.] -- Bone metastasis and pathological fractures : bone tissue engineering as a novel therapy / Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singh -- Role of photodynamic therapy for bone metastasis / Shane Burch and Albert J.M. Yee -- Docetaxel for metastatic cancer and its role in combination therapies for advanced prostate cancer / Ellen K. Wasan ... [et al.] -- The use of tetracyclines for bone metastasis / Eric Seidlitz, Zeina Saikali, and Gurmit Singh -- Role of bisphosphonates in skeletal metastases / Arif Hussain and Fred Saad -- Radiation treatment of bone metastases / Edward Chow, Jackson Wu, and Elizabeth Toni Barnes.
  • Bone sarcoma 2013
    Multidisciplinary approach to the management of sarcomas of bone / Bryan S. Moon -- Bone sarcoma imaging / John E. Madewell ... [et al.] -- Percutaneous image-guided biopsy for diagnosis of bone sarcomas / Kamran Ahrar -- Orthopedic oncologic surgical specimen management and surgical pathology / A. Kevin Raymond and Alexander J. Lazar -- Osteosarcoma / Patrick P. Lin and Shreyaskumar Patel -- Ewing sarcoma / Patrick P. Lin ... [et al.] -- Chondrosarco / Alan W. Yasko, Vinod Ravi, and Ashleigh Guadagnolo -- Rare bone sarcomas / Valerae O. Lewis ... [et al.] -- Skeletal reconstruction after bone sarcoma resection / Christopher P. Cannon and David W. Chang -- Soft tissue reconstruction after bone sarcoma resection / Scott D. Oates -- Bone sarcomas in the growing child / Valerae O. Lewis and David W. Chang -- Perioperative management of patients with bone sarcomas / Janie Rutledge, Mark S. Pilarczyk, and Alan W. Yasko -- Rehabilitation in orthopedic oncology / Benedict Konzen and Christopher P. Cannon -- Follow-up evaluation and surveillance after treatment of bone sarcomas / Colleen M. Costelloe and Patrick P. Lin.
  • Introduction to Bone Tumors -- How to Evaluate a Bone Lesion -- Imaging Modalities -- Cartilage Tumors -- Osseous Tumors -- Fibrous Tumors -- Miscellaneous Tumors -- Bone Metastases -- Bone Tumor Mimickers -- Cases.
  • Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
  • Brain cancer 2010
  • Brain metastases 2007
    Also available: Print – 2007
  • With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This volume fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types -- lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.
  • Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.
  • Brain tumor imaging 2015
    Conventional morphologic imaging : MRI remains the workhorse -- Benjamin Cohen, Inna Nutanson, and Girish M. Fatterpekar -- Response assessment in neuro-oncology / Tom Mikkelsen and Tobias Walbert -- Going beyond the conventional morphologic imaging : an overview of functional imaging techniques / Marco Essig and Cem Calli -- Perfusion imaging : DSC MR perfusion / Marco Essig, Joseph Puig Alcantara, and Cem Cali -- Perfusion imaging : dynamic contrast enhanced T1-weighted MRI (DCE-MRI) perfusion / David Fussell and Robert J. Young -- Perfusion imaging : arterial spin labeling / S. Ali Nabavizadeh, Suyash Mohan, Jeffrey M. Pollock -- Perfusion imaging : CT perfusion / Brent Griffith and Rajan Jain -- Diffusion weighted imaging for gliomas / Benjamin M. Ellingson, Bryan Yoo, and Whitney B. Pope -- Diffusion tensor imaging / Bram Stieltjes and Peter Neher -- Functional MRI and diffusion tensor imaging with tractography / Anna Knobel and Robert J. Young -- Metabolic imaging : MR spectroscopy / Isabella Björkman-Burtscher and Pia C. Sundgren -- Molecular imaging : PET and SPECT / Asim K. Bag and Samuel E. Almodóvar -- It's not just the tumor : treatment effects / Brent Griffith and Rajan Jain -- It's not just the tumor : CNS paraneoplastic syndromes and cerebrovascular complications of cancers / Prashant Nagpal and Rajan Jain -- Image guided neurosurgery : intraoperative MRI / Ian Y. Lee -- On the horizon : ultra-high-field MR / Steffen Sammet and Alexander Radbruch -- On the horizon : tumor genomics / Rivka R. Colen, Faisal Tai, and Pascal O. Zinn -- On the horizon : going beyond the conventional MR contrast agents / Josep Puig and Wilson B. Chwang -- On the horizon : molecular imaging / Sanath Kumar, Meser M. Ali, and Ali Syed Arbab.
  • Brain tumors 2005
    Epidemiology of brain tumors / Randa El-Zein, Melissa Bondy, and Margaret Wrensch -- Molecular genetics of tumors of the central nervous system / C. David James -- Molecular pathology of nervous system tumors / Catherine L. Nutt ... [et al.] -- Genetic modeling of glioma formation in mice / Martin Begemann ... [et al.] -- Biology of brain metastasis / Minsoo Kang ... [et al.] -- Analysis of neural precursor cells in the context of origin of brain tumors, their treatment, and repair of treatment-associated damage / Mark Noble and Joerg Dietrich -- Biology of primitive neuroectodermal tumors / John R. Hill, Shoichiro Ohta, and Mark A. Israel -- Molecular and cellular biology of the blood-brain barrier and its characteristics in brain tumors / Helga E. de Vries ... [et al.] -- Immune regulation in the brain : lessons from autoimmunity and implications for brain tumor therapy / Lois A. Lampson -- Genetic pathways in the evolution of gliomas / Hiroko Ohgaki and Paul Kleihues -- DNA damage and repair in the therapeutic response of tumors of the central nervous system / Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman -- Role of urokinase-type plasminogen activator receptor in human glioma invasion / Sanjeeva Mohanam and Jasti S. Rao -- Regulation of the cell cycle and apoptosis in human brain tumors / Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell -- Systemic chemotherapy for metastatic tumors of the central nervous system / Charles A. Conrad and W.K. Alfred Yung -- Radiation biology and therapy of tumors of the central nervous system / Nalin Gupta ... [et al.] -- Advances in the management of cerebral metastases / Fadi Hanbali and Raymond Sawaya -- Immunotherapy of central nervous system tumors: contemporary cancer research / Amy B. Heimberger ... [et al.] -- Targeting drugs to tumors of the central nervous system / Maciej S. Lesniak, James Frazier, and Henry Brem -- Rational design and development of targeted brain tumor therapeutics / Francis Ali-Osman ... [et al.].
  • 2011 ClinicalKey
    Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. You'll also have easy access to the complete contents online, with links to PubMed and a downloadable image library, at Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.
  • Burden of Breast and Gynecological Cancers in Low-Resource Countries -- Breast Cancer: Pathology, Cytology, and Core Needle Biopsy Methods for Diagnosis -- Gynecological Cancers: Pathology and Cytological Methods for Diagnosis of Gynecological Cancers -- Screening and Early Diagnosis of Breast Cancer: Proven Methodology and an Optimized Strategy for Developing Countries -- HPV and Cervical Cancer -- Screening for Cervical Cancer in Low-Resource Countries -- Ovarian Cancer Screening and Early Detection in Low- and Middle-Income Countries -- Endometrial Cancer: Risk Factors and Early Diagnosis in Low-Resource Countries -- Breast and Gynecologic Cancer Prevention in Low-Resource Countries -- Combined Screening for Breast and Gynecological Cancers Using Mobile Clinics: The Barretos Experience (Brazil) -- Cost-Effectiveness of Screening for and Early Diagnosis of Breast and Gynecological Cancers in Low-Income Countries -- Challenges for Breast and Gynecological Cancer Control by Early Detection in Less-Developed Countries -- Funding for Global Healthcare Intervention: Initiatives Aimed at Controlling Cancer in Women in Low-Resource Countries -- Coordinated Training on Early Detection and Diagnosis of Breast Cancer Across Different Levels of Health Workers: An Example from Peru -- Telemedicine in Cancer Control Programs in Developing Countries -- Breast Cancer Screening and Cervical Cancer Prevention in Developing Countries: Strategies for the Future -- Well Woman Clinic Concept: An Integrated Approach for Screening and Early Diagnosis of Breast and Gynecological Cancers in Developing Countries.
  • Breast cancer 2011
    The normal breast and benign diseases of the breast / Samia Nawaz -- Ductal and lobular proliferations : preinvasive breast disease / Meenakshi Singh and Jon V. Rittenbach -- Invasive breast cancer / Michael D. Stamatakos -- Risk factors and risk assessment / Nancy S. Goldman and Constance R. Ziegfeld -- Genetics / Jennifer E. Axilbund, Amy L. Gross, and Kala Visvanthan -- Strategies for risk reduction / Anna Voltura and Lisa Jacobs -- Nutrition and lifestyle / Lisa Ware Corbin -- Radiologic techniques for early detection and diagnosis / John M. Lewin -- Screening of high-risk patients / James P. Borgstede and Brian Bagrosky -- Minimally invasive breast biopsy / Steve H. Parker, Terese I. Kaske, and Judy L. Chavez -- Surgical biopsy / Elizabeth Prier -- Surgical therapy of early breast cancer / Michael Ford and Christina A. Finlayson -- Breast reconstruction after mastectomy / Alex Colque, Hanjoon Song, and Erica D. Anderson -- Oncoplastic surgical techniques for the partial mastectomy / Chin-Yau Chen, Kristine E. Calhoun, and Benjamin O. Anderson -- Axillary management / M. Catherine Lee and Michael S. Sabel -- Radiation oncology / Richard Zellars, Timothy George, and Lee Myers -- Neoadjuvant therapy / Susanne Briest and Vered Stearns -- Cost-effective staging of breast cancer / Virginia F. Borges and Lara Hardesty -- Adjuvant systemic therapy / Anthony D. Elias, Daniel Bowles, and Peter Kabos -- Surveillance and detection of recurrence of breast cancer / Peter Kabos and Virginia F. Borges -- The use of molecular profiles in the management of breast cancer / Anthony D. Elias -- Partial breast irradiation / Rachel Rabinovitch -- Breast cancer and pregnancy / Scott W. McGee and Donald C. Doll -- Mammary ductoscopy / Edward R. Sauter.
  • Also available: Print – 2005
  • The volume raises attention to the need of a completely new approach to breast cancer based on the knowledge collected on early breast cancer in the past two decades. The chapters are contributed by experts of all the fields participating in the clinical research and care of breast cancer. The practical importance of such a book is underlined by the increasing number of breast cancer cases, and also the increasing proportion of early stage-cases. The ultimate goal of the book is to point to the heterogeneous nature of the disease which is more striking and has more importance in care at the very early stages than at the more advanced stages. The book recommends the utilisation of all the information provided by multimodality imaging and special pathological methods, a new classification system and therapeutic guidelines since early breast cancers should not be treated based on experience obtained with palpable tumors. No similar book has been yet released to the market. The book is written for all the members of the team participating in the diagnosis and treatment of breast cancer (radiologists, pathologists, surgeons, clinical and radiation oncologists), but may be useful for medical students and residents too. The chapters are illustrated with didactic pictures, and special emphasis is given to provide a peep into the practice of the special procedures for the careful examination and individualized therapy of each case.
  • The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. "Breast Cancer: A Lobar Disease," presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts.
  • Breast Cancer: A New Era in Management provides a compendium of succinct analysis of the many facets involved in the present day management of the breast cancer patient. The text provides the clinician or student with basic foundational knowledge in the rapidly expanding areas of expertise that are required for both the diagnosis and treatment of the breast cancer patient. Each topic, whether diagnostic or therapeutic, is presented in a straightforward fashion incorporating as part of each topic a description of the historical clinical landmarks leading to the present day, their present day position in the care of the breast patient, and finally, an assessment of possible future application and adaptation in clinical practice. Emphasis is placed on clear and concise explanations of each topic presented in stepwise fashion from fundamental elements to the more complex. Breast Cancer: A New Era in Management will act as a ready reference for the practicing surgeon and students seeking practical information on a particular clinical topic or scenario.
  • Overview -- Common benign conditions of low concern -- Benign conditions associated with a risk for the subsequent development of cancer -- Precursor lesions and noninvasive cancers -- Breast cancer -- Things pathologists must always consider -- Nuances and details of the pathology report.
  • The large and increasing burden of breast cancer demands innovative research and bold new approaches to uncover the intricate combination of factors inside and outside the body that lead to the disease. Based on our review of the state of the science, current programs and investments by federal agencies and nongovernmental organizations, and relevant communication efforts and policies, the IBCERCC offers seven recommendations to highlight the urgent need for coordinated, targeted efforts to identify and mitigate the environmental causes of breast cancer.
  • Breast Cancer Biology for the Radiation Oncologist is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable. All of these emerging issues of central importance to radiation oncologists are extensively discussed in this book, and practical treatment recommendations based on available clinical evidence are presented whenever possible.
  • Also available: Print – 2007
    Overview of resistance to systemic therapy in patients with breast cancer / Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez and Gabriel N. Hortobagyi -- Roles of multidrug resistance genes in breast cancer chemoresistance / M. Tien Kuo -- Therapy-induced apoptosis in primary tumors / David J. McConkey -- Cell cycle deregulation in breast cancer: insurmountable chemoresistance or achilles' heel? / Laura Lambert and Khandan Keyomarsi -- p53, BRCA1 and breast cancer chemoresistance / Kimberly A. Scata and Wafik S. El-Deiry -- Integrin-mediated adhesion: tipping the balance between chemosensitivity and chemoresistance / Mary M. Zutter -- Insulin-like growth factors and breast cancer therapy / Xianke Zeng and Douglas Yee -- EGF receptor in breast cancer chemoresistance / Robert B. Dickson and T.B. Deb -- Molecular mechanisms of ErbB2-mediated breast cancer chemoresistance / Ming Tan and Dihua Yu -- Estrogen receptors in resistance to hormone therapy / Matthew H. Herynk and Suzanne A.W. Fuqua -- Novel approaches for chemosensitization of breast cancer cells: the E1A story / Yong Liao, Dihua Yu and Mien-Chie Hung.
  • Global burden of breast cancer / Jacques Ferlay ... [et al.] -- Breast cancer biology and clinical characteristics / Amanda I. Phipps and Christopher I. Li -- In situ breast cancer / Brian L. Sprague and Amy Trentham-Dietz -- Endogenous hormones / Amanda I. Phipps and Christopher I. Li -- Exogenous hormones / Christopher I. Li and Elisabeth F. Beaber -- Reproductive factors / Mats Lambe -- Physical activity and anthropometric factors / Katherine D. Henderson, Jennifer Prescott, and Leslie Bernstein -- Diet and nutrition / Martin Lajous and Shumin M. Zhang -- Environmental and occupational exposures / Amanda I. Phipps ... [et al.] -- Shift work and circadian disruption / Scott Davis and Dana K. Mirick -- Non-hormonal medications and chronic diseases / Patricia F. Coogan -- Male breast cancer / Ian S. Fentiman -- Inherited predisposition: familial aggregation and high risk genes / Kathleen E. Malone and Kerryn W. Reding -- Common genetic susceptibility loci / Mikkel Z. Oestergaard and Paul Pharoah -- Mammographic density as a potential surrogate marker for breast cancer / Norman F. Boyd, Lisa J. Martin, and Salomon Minkin -- Breast cancer screening / Karla Kerlikowske -- Principles of breast cancer therapy / Allison W. Kurian and Robert W. Carlson -- Breast cancer outcomes / Graham A. Colditz and Courtney Beers.
  • Epidemiology.- Managing breast cancer in young women -- Impact of breast cancer treatment on fertility.- Fertility preservation and ART -- Breast cancer during pregnancy.- Pregnancy after breast cancer -- Reproductive issues in BRCA mutation carriers.
  • Through a case-based approach, this book illustrates the best practices for all facets of breast cancer imaging - from screening of asymptomatic patients to cancer staging, identifying metastases, and assessing efficacy of treatment - in a succinct, practical source. Contributing authors from a wide range of subspecialties provide well-rounded guidance to meet the needs of today₂s multidisciplinary work environment. Presents multidisciplinary discussions on the advantages and/or limitations of all available modalities. Includes advice from leading experts on cross-sectional imaging, breast imaging, and PET/CT, with input from radiation oncology, medical oncology, and breast surgery, to span the complete spectrum of care from screening to diagnosis to treatment, reflecting today₂s team approach to patient care. Covers all imaging modalities to help you correlate disease presentations on mammography, CT, MR, US, and PET images. Offers a very practical, clinical, concise approach to the subject in a case-based format. Provides over 1,000 high-resolution images of disease appearance for comparison with the findings you encounter in your practice.
  • Also available: Print – 2006
    Print Material
    Burden of breast cancer in developing and developed countries -- Genetics of breast cancer in women of African Descent: an overview -- Biology of breast cancer: molecular and pathologic features of ductal neoplasia of the breast: racial considerations -- Screening and early detection of breast cancer in women in Africa and the Middle East -- Breast cancer at diagnosis in women of Africa and the Middle East -- Breast cancer aggressiveness in women of African descent -- Radiotherapy of breast cancer -- Adjuvant therapy of breast cancer -- Endocrine therapy of breast cancer -- Palliative care for breast cancer in the African-American population -- Outcome of African American women with breast cancer in cooperative group clinical trials -- Traditional medicine in breast cancer management with a focus on the Chinese integrative approach -- Impact of culture, education and socio-economic status -- Barriers to successful management of breast cancer.
  • This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to fully understand the disease with all its heterogeneity ; understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity, metastasis, drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed -- source other than Library of Congress.
  • Breast cancer research protocols 2005
    Springer Protocols
    Breast tissue banking: collection, handling, storage, and release of tissue for breast cancer research / Linda Snell and Peter H. Watson -- Frozen biopsy collection and storage: frozen biopsy samples / Russell Leek -- Serial biopsies/fine-needle aspirates and their assessment / Irene Boeddinghaus and Stephen R.D. Johnson -- Breast tissue microarrays / Robert J. Springall and Cheryl E. Gillett -- Preparation of tumor homogenates for subsequent preparation of cytosols, membrane fractions, RNA, and DNA / Naomi Robertson and Russell Leek -- Isolation of RNA from tumor samples: single-step guanidinium acid-phenol method / Naomi Robertson and Russell Leek -- Isolation of DNA from tumor samples / Naomi Robertson and Russell Leek -- Laser-assisted microdissection and isolation of DNA and RNA / Ulrich Lehmann and Hans Kreipe -- Fluorescence in situ hybridization and comparative genomic hybridization / Patricia Gorman and Rebecca Roylance -- Fluorescence in situ hybridization assessment of c-myc gene amplification in breast tumor tissues / Jan K. Blancato, Mary Steele Williams, and Robert B. Dickson -- Detection of HER2 gene amplification by fluorescence in situ hybridization in breast cancer / John M.S. Bartlett, and Amanda Forsyth -- In situ hybridization combined with immunohistochemistry to localize gene expression / Rosemary Jeffery, Toby Hunt, and Richard Poulsom -- Quantitation of RNA by ribonuclease protection assay / John W. Moore -- Identification of steroid hormone-regulated genes in breast cancer / Bruce R. Westley and Felicity E.B. May -- Sequencing of the tumor suppressor gene TP 53 / Barbro Linderholm, Torbjörn Norberg, and Jonas Bergh -- Expression profiling using cDNA microarrays / Chris Jones ... [et al.] -- Gene expression analysis using filter cDNA microarrays / Peter Simpson ... [et al.] -- Immunohistochemistry / Cheryl E. Gillett -- Detection of aberrant glycosylation in breast cancer using lectin histochemistry / Tracey M. Carter and Susan A. Brooks -- SDS-PAGE and western blotting to detect proteins and glycoproteins of interest in breast cancer research / Chloe Osborne and Susan A. Brooks -- Breast cancer proteomics using two-dimensional electrophoresis: studying the breast cancer proteome / Miriam V. Dwek and Sarah L. Rawlings -- Procedures for the quantitative protein determination of urokinase and its inhibitor PAI-1 in human breast cancer tissue extracts using ELISA / Manfred Schmitt ... [et al.] -- Methods to analyze the effects of the urokinase system on cancer cell adhesion, proliferation, migration, and signal transduction events / Ute Reuning ... [et al.] -- Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage / Kum Kum Khanna, Magtouf Gatei, and Gordon Tribbick -- Models of hormone resistance in vitro and in vivo / Jennifer MacGregor Schafer and V. Craig Jordan -- Generation of genetically modified embryonic stem cells for the development of knockout mouse animal model systems / Stephen D. Robinson, Stephen Wilson, and Kairbaan M. Hodivala-Dilke -- In vivo xenograft models of breast cancer metastatsis / Ursula Valentiner, Susan A. Brooks, and Udo Schumacher -- Neoadjuvant endocrine therapy models / Juliette Murray, William R. Miller, and J. Michael Dixon -- Primary mouse endothelial cell culture for assays of angiogenesis / Louise E. Reynolds and Kairbaan M. Hodivala-Dilke. Traditional and established indicators of prognosis and treatment success / Derek E. Roskell and Ian D. Buley -- Sentinel lymph node biopsy in breast cancer / Celia Chao and Kelly M. McMasters -- Pathological evaluation of axillary sentinel lymph nodes in breast cancer / Michael Z. Gilcrease and Aysegul Sahin -- Measurement of estrogen receptor status by immunocytochemistry in paraffin wax sections / Bharat Jasani ... [et al.] -- Markers of apoptosis / Falzul H. Sarkar and Yiwei Li -- Quantitative angiogenesis in breast cancer / Stephen B. Fox --
  • Part I. Prevention -- Risk Factors / Polly A. Newcomb and Karen J. Wernli -- Lifestyle Factors and Risk of Breast Cancer: A Review of Randomized Trial Findings / Garnet L. Anderson -- Breast Cancer Chemoprevention / Mary B. Daly -- Surgical Management of Inherited Susceptibility to Breast Cancer / Francis Freisinger and Susan M. Domchek -- Part II. Early Detection -- Clinical Breast Examination and Breast Self-Examination / William H. Goodson -- Mammography / Barbara C. Cavanaugh and Sorcha McNally -- Current Status and Future Prospects in Breast Carcinoma of Positron Emission Tomography / Sandip Basu, Joshua I. Rosenbaum and Abass Alavi -- Breast MRI / Barbara C. Cavanaugh and Sorcha McNally -- Genetic and Molecular Approaches to Imaging Breast Cancer / Eric Wickstrom and Mathew L. Thakur -- Intraductal Approaches: Nipple Aspirate Fluid to Assist in Breast Cancer Detection / Edward R. Sauter -- Intraductal Approaches: Mammary Ductoscopy and Ductal Lavage to Assist in the Diagnosis of Breast Cancer / William C. Dooley -- Blood Markers / Mark W. Duncan -- Circulating Tumor Cells in Breast Cancer / Michail Ignatiadis and Dimitris Mavroudis.
  • This book presents the current trends and practices in breast imaging. Topics include mammographic interpretation; breast ultrasound; breast MRI; management of the symptomatic breast in young, pregnant, and lactating women; breast intervention with imaging pathological correlation; the postoperative breast; and current and emerging technologies in breast imaging. It emphasizes the importance of fostering a multidisciplinary approach in the diagnosis and treatment of breast diseases. Featuring more than 800 high-resolution images and showcasing contributions from leading authorities in the screening, diagnosis, and management of the breast cancer patient, Breast Cancer Screening and Diagnosis is a valuable resource for radiologists, oncologists, and surgeons. Mahesh K. Shetty is a Clinical Professor of Radiology at Baylor College of Medicine and the chief physician at the Woman?s Center for Breast Care & MRI at The Woman?s Hospital of Texas.
  • Breast carcinoma 2008
  • The Breast: Comprehensive Management of Benign and Malignant Diseases, 4th Edition, by Kirby I. Bland, MD, and Edward M. Copeland, III, MD, is a surgical reference that offers the most comprehensive, up-to-date resource on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. With its multidisciplinary approach, sweeping updates, new contributors, and authoritative guidance, you₂ll have exactly what you need to inspire patient confidence and provide the best possible outcomes. Best of all, this new edition comes to you in print and online for easy, convenient access to the absolute latest advances. Features multidisciplinary advice from experts in surgery, radiation and medical oncology, pathology, molecular biology, pharmacokinetics, and genetics for a well-rounded perspective to enhance patient outcomes. Includes more than 1,500 figures and tables that offer high quality depictions of surgery and treatment procedures. Offers step-by-step guidance through both text and clinical boxes that makes the material relevant to everyday practice. Provides cross-referencing between chapters, as well as references to carefully selected journal articles, that makes further research easier.
  • Introduction and general considerations -- Well-circumscribed solid lesions -- Well-circumscribed solid lesions with heterogeneous radiodensity -- Largely cystic lesions -- Partially solid, partially cystic lesions -- Well-circumscribed solid malignancies -- Irregular densities -- Spiculated architectural distortion -- Architectural distortion -- Introduction to stereotactic core biopsies for calcifications -- Calcium oxalate crystals -- Linear high-density calcifications -- Clustered low-density granular calcifications -- Linear and branching calcifications -- Miscellaenous unusual and rare lesions -- Complications and follow-up: after the core biopsy -- Postscript.
  • Breast Disease: Comprehensive Management provides a clear, concise source of information in order to make real-life, evidence-based decisions for all aspects of breast disease, both benign and malignant. The volume provides the latest breakthroughs in breast cancer research, ranging from paradigm shifts in the surgical management of the axilla, the changing role of adjuvant and neoadjuvant chemotherapy, the impact of molecular medicine in decision-making and the controversial role of prophylactic mastectomy in our era. Within select chapters, ℓ́ℓHow I do itℓ́ℓ clinical scenarios are supplied and described in very practical terms. Also included at the end of each chapter are synoptic questions with detailed answers, akin to the self-assessment (SESAP) format questions and answers. These questions provide a basis for continuous medical education (CME) for the practicing physician and surgeon, further in surgical oncology and breast surgery, medical oncologists, radiation oncologists, and breast radiologists enhancing a focused approach to the management of breast disease in preparation for the American Board of Surgery certification and re-certification for the general surgeon. This title is of great value to general surgeons, breast surgeons, surgical oncologists, general surgery residents, and fellows
  • It is challenging enough to be able to make a diagnosis in mammography, but the newer standards of care demand more than just providing a diagnosis. This book is an excellent resource to improve the understanding of breast diseases, recognize and manage problems encountered in breast imaging and clinical management of the breast diseases. With forty four chapters, this volume is divided into six sections on screening of breast cancer, imaging modalities, benign breast disorders, interventional procedures, pathological considerations and breast cancer. Breast Diseases: Imaging and Clinical Management is a crisp volume on clinical and multimodality breast imaging with emphasis on interventional procedures, pathology and the entire spectrum of breast cancers.
  • Breast elastography 2015
    Thieme Book
    "Elastography is a noninvasive imaging technique that detects tumors based on their stiffness compared to normal tissue. It uses ultrasound technology and can be performed during an ultrasound examination of the breast. It can dramatically reduce the number of breast biopsies performed. This book introduces the techniques of breast elastography followed by a detailed description for each of the techniques, highlighting their pros and cons. This is followed by a section on how to perform each of the techniques. The third section discusses the methods of interpretation for each technique, and the final section presents cases studies highlighting the pros and cons of each technique and how to avoid pitfalls in interpretation. It is written to appeal to the beginner as well as the experienced user"--Provided by publisher.
  • Written by internationally acclaimed specialists, Breast, Endocrine and Surgical Oncology provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated throughout by photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Breast, Endocrine and Surgical Oncology provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.
  • Breast imaging 2011
    History of Breast Imaging -- Epidemiology of Breast Cancer -- Screening Results, Controversies, and Guidelines -- Mammography and Digital Equipment -- Computer-Aided Detection -- Positioning in Mammography -- Clinical Image Evaluation -- Mammography Quality Control : Digital and Screen-Film -- Ultrasound Equipment -- Ultrasound Indications and Interpretation -- Magnetic Resonance Equipment and Techniques -- Magnetic Resonance Imaging : Indications and Interpretation -- BI-RADS, Reporting, and Communication -- The Normal Breast -- Benign Cystic Lesions of the Breast -- Solid Benign Lesions of the Breast -- Proliferative Lesions -- Typical Benign Calcifications -- High-Risk Breast Diseases -- Infectious and Inflammatory Diseases of the Breast -- Ductal Carcinoma in Situ and Paget's Disease -- Invasive Ductal Carcinomas -- Invasive Lobular Carcinoma -- Other Malignant Breast Diseases -- The Effect of Neoadjuvant Chemotherapy and Radiation Therapy on Breast Tissue -- American College of Radiology Appropriateness Criteria -- Appropriate Management of Masses -- Appropriate Management of Calcifications -- Image-Guided Percutaneous Biopsy -- Galactography -- Presurgical Needle Localization -- Specimen Processing in Pathology -- Post-Biopsy Management -- The Conservatively Treated Breast -- The Augmented Breast -- Reduction Mammoplasty -- The Mammography Quality Standards Act and Accreditation -- The Medical Audit : Statistical Basis of Clinical Outcomes Analysis -- Coding and Billing in Breast Imaging -- Medical-Legal Aspects of Breast Imaging and Intervention -- Emerging X-Ray-Based and Nuclear Technologies -- Ultrasound-Based Technologies Including Elastography and Automated Whole Breast Scanning -- Recent Advances in Magnetic Resonance Spectroscopy in the Breast -- Minimally Invasive Percutaneous Breast Cancer Ablation.
  • Effectively prepare for certification, recertification, and practice with Breast Imaging: Case Review, 2nd Edition! Case studies illustrate how to make confident, final diagnoses through accurate pattern recognition, clinical correlation, and differential diagnosis. It's an ideal way to test and deepen your knowledge of all essential topics in breast imaging. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter.
  • Also available: Print – 2007
    Breast anatomy and basic histology, physiology, and pathology -- A pathologist's overview of the pathology of breast disease / Joseph Rabban -- Epidemiology, etiology, risk factors, and survival from breast cancer -- Screening for breast cancer -- Radiation risk -- Staging breast cancer -- Ductal carcinoma in situ and early-stage breast cancer: detection, diagnosis, and prognostic indicators -- Mammography: equipment and basic physics -- Quality assurance and quality control / Debra Deibel -- Mammographic positioning -- A systematic approach to breast imaging -- Mammography and the normal breast -- Interpreting the mammogram -- Benign lesions -- Probably benign findings appropriately managed with short-interval follow-up -- Suspicious lesions and lesions with a high probability of malignancy -- Breast ultrasound -- The altered breast: pregnancy, lactation, abscess, post biopsy changes, mastectomy, radiation, and implants -- The male breast -- Magnetic resonance imaging of the breast / Carol A. Hulka and Daniel B. Kopans -- Evaluating women with lumps, thickening, discharge or pain: imaging women with signs or symptoms that might indicate breast cancer -- Image sequencing: problems and solutions in breast evaluation -- Histological, pathological and imaging correlation -- Interventional procedures in the breast -- The breast imaging report: data management and the breast imaging audit -- The medical-legal problem and breast imaging -- Digital mammography -- Digital breast tomosynthesis -- Cytopathology.
  • Breast MRI 2013
    Breast MRI is a comprehensive, practical resource entirely devoted to this state-of-the-art technique, which has emerged as a valuable adjunct to the conventional imaging modalities in the detection of primary and recurrent breast cancer. This brand-new medical reference book utilizes an atlas-type format that showcases numerous examples of each aspect of breast MRI, equipping you with the latest knowledge on effective breast image interpretation. Compare your breast imaging findings to a wealth of breast MRI examples that capture the characteristic clinical presentation of both normal and diseased patients. Apply the most up-to-date information available on all aspects of breast MRI, including MRI-guided biopsy, breast cancer screening with MRI, MRI features of benign and malignant lesions, and MRI in the evaluation of newly diagnosed breast cancer.Take advantage of an image-rich, atlas-type format that offers the visual clarity you need for accurate interpretation.Access the full text and images online at Expert Consult.
  • Breast pathology 2012
    Normal Breast and Developmental Disorders -- Reactive and Inflammatory Conditions of the Breast -- Infections of the Breast -- Epidemiology of Breast Cancer -- Patient Safety in Breast Pathology -- Gross Examination of Breast Specimens -- Sentinel Lymph Node Biopsy -- Breast Imaging Modalities for Pathologists -- Predictive and Prognostic Marker Testing in Breast Pathology: Immunophenotypic Subclasses of Disease -- Molecular-based Testing in Breast Disease for Therapeutic Decisions -- Diagnostic Immunohistology of the Breast -- Fibroepithelial Lesions -- Papilloma and Papillary Lesions -- Adenosis and Microglandular Adenosis -- Nipple Adenoma (Florid Papillomatosis of the Nipple) -- Radial Scar -- Myoepithelial Lesions of the Breast -- Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type -- Columnar Cell Alterations, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia -- Molecular Classification of Breast Carcinoma -- Lobular Neoplasia and Invasive Lobular Carcinoma -- Ductal Carcinoma In Situ -- Invasive Ductal Carcinoma of No Special Type and Histologic Grade -- Triple-Negative and Basal-like Carcinoma -- Metaplastic Breast Carcinoma -- Apocrine Carcinoma of the Breast -- Paget's Disease of the Breast -- Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma -- Special Types of Breast Carcinoma: Tubular Carcinoma, Mucinous Carcinoma, Cribriform Carcinoma, Invasive Micropapillary Carcinoma, and Medullary Carcinoma -- Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma with Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma -- Mesenchymal Neoplasms of the Breast -- Neoplasia of the Male Breast -- Breast Tumors in Children and Adolescents -- Tumors of the Mammary Skin -- Hematopoietic Tumors of the Breast -- Metastatic Tumors in the Breast.
  • Breast surgery. 5th ed. 2014
    The role of imaging in breast diagnosis including screening and excision of impalpable lesions / A. Robin M. Wilson and R. Douglas Macmillan -- Pathology and biology of breast cancer / Rajendra S. Rampaul ... [et al.] -- Nipple discharge and the role of ductoscopy in breast diseases / Sarah Tang and Gerald Gui -- Breast-conserving surgery : the balance between good cosmesis and local control / J. Michael Dixon -- Techniques of mastectomy : tips and pitfalls / R. Douglas Macmillan -- Oncoplastic procedures to allow breast conservation and a satisfactory cosmetic outcome / Richard M. Rainsbury ... [et al.] -- The axilla : current management including sentinel node and lymphedema / Anees B. Chagpar -- The genetics of breast cancer, risk-reducing surgery, and prevention / D. Gareth, R. Evans and Ava Kwong -- Breast reconstruction / Mark Schaverien and Cameron Raine -- Breast cancer treatments of uncommon diseases / Daniel Xavier Choi and Monica Morrow -- Treatment of ductal carcinoma in situ / Nicola L.P. Barnes and Nigel J. Bundred -- The role of adjuvant systemic therapy in patients with operable breast cancer / Rosalie Fisher and Ian Smith -- Locally advanced breast cancer / Douglas J.A. Adamson and Alastair M. Thompson -- Metastatic disease and palliative care / John Dewar and Pamela Levack -- The role of adjuvant radiotherapy in the management of breast cancer / Ian Kunkler -- Psychosocial issues in breast cancer / Lesley Fallowfield and Valerie Jenkins -- Benign breast disease / Steven Thrush and J. Michael Dixon -- Litigation in breast surgery / Tim Davidson and Tom Bates.
  • Also available: Print – 2011
    Pt. 1. Fundamentals -- pt. 2. Biologic principles -- pt. 3. Initial evaluation of the patient -- pt. 4. Common presenting complaints and concerns -- pt. 5. Diagnostic techniques -- pt. 6. Breast cancer overview -- pt. 7. Breast surgery : management of the primary tumor -- pt. 8. Breast surgery : sentinel node biopsy and axillary dissection -- pt. 9. Breast surgery : special issues -- pt. 10. Cytology and pathology -- pt. 11. Systemic therapy for breast cancer -- pt. 12. Radiation therapy of the breast -- pt. 13. The breast cancer survivor.
  • Breast ultrasound 2013
    Diagnosis of breast cancer: modern aspects -- Technique of breast ultrasound -- Ultrasound of the normal breast -- Ultrasound diagnosis of breast cancer -- Classification of breast masses -- Ultrasound features of different types of breast cancer -- Differential diagnosis of breast diseases -- Age-related changes in breast structure: breast ultrasound in children and adolescents -- Breast pathology in men -- Ultrasound examination of regional lymph nodes -- Ultrasound examination after breast surgery -- Recurrent breast cancer.
  • Burkitt's lymphoma 2013
    This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt's lymphoma.
  • Also available: Print – 2008
  • Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai -- Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart -- Inhibitors of topoisomerase I function / Sidney M. Hecht -- Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.] -- Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti -- Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.] -- Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin -- Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.] -- Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto -- Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen -- Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory -- Clinical experience with topotecan / Aimee K. Bence and Val R. Adams -- The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.] -- Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky -- Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman -- Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.] -- Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.
  • Chronic mechanistic target of rapamycin inhibition : preventing cancer to delay aging, or vice versa? / Sharp, Z.D.; Curiel, T.J.; Livi, C. -- Senescent cells and their secretory phenotype as targets for cancer therapy / Velarde, M.C.; Demaria, M.; Campisi, J. -- Cancer vaccination at older age / Gravekamp, C. -- Immunology of aging and cancer development / Fulop, T. ... [et al.] -- Metabolic syndrome and cancer : from bedside to bench and back / Extermann, M. -- Frailty : a common pathway in aging and cancer / Balducci, L. -- Targeting age-related changes in the biology of acute myeloid leukemia : is the patient seeing the progress? / Vey, N. -- Comprehensive geriatric assessment in oncology / Mohile, S.G.; Magnuson, A. -- Pharmacology of aging and cancer : how useful are pharmacokinetic tests? / Lichtman, S.M. -- Surgery in older cancer patients : recent results and new techniques : worth the investment? / Van Leeuwen, B.L.; Huisman, M.G.; Audisio, R.A. -- Organizing the geriatrician/oncologist partnership : one size fits all? practical solutions / Holmes, H.M.; Albrand, G. -- Geriatric oncology nursing : beyond standard care / Overcash, J. -- Exercise for older cancer patients : feasible and helpful? / Klepin, H.D.; Mohile, S.G. ; Mihalko, S. -- Aging and cancer : addressing a nation's challenge / Brochot, J.-M.; Le Quellec-Nathan, M.; Buzyn, A.
  • 1. Obesity and Cancer Epidemiology -- 2. Obesity and Cancer: Epidemiology in Racial/Ethnic Minorities -- 3. Obesity and Cancer in Asia -- 4. Genetic Epidemiology of Obesity and Cancer -- 5. Obesity and Cancer: Overview of Mechanisms -- 6. Caloric Restriction and Cancer -- 7. Physical Activity and Cancer -- 8. Energy Balance, Cancer Prognosis, and Survivorship -- 9. Behavior, Energy Balance, and Cancer: An Overview -- 10. Geographic and Contextual Effects on Energy Balance-Related Behaviors and Cancer.
  • Also available: Print – 2008
  • Functional Anatomy of the Male Sex Organs -- Functional Anatomy of the Female Sex Organs -- Physiology of Libido -- Physiology of Orgasm -- Physiology of Female Genital Sexual Arousal -- Physiology of Erection -- Physiology of Ejaculation -- Classifying Female Sexual Dysfunction -- Hypoactive Sexual Desire Disorder -- Disorders of Female Sexual Arousal -- Disorders of Female Orgasm -- Sexual Pain Disorders -- Erectile Dysfunction: Prevalence and Pathophysiology -- Androgen Deficiency -- Peyronie?s Disease -- Disorders of Ejaculation and Male Orgasm -- Priapism -- The Sexual Health Interview: Male -- The Sexual Health Interview: Female -- Communication About Sexuality and Cancer -- Validated Questionnaires in Female Sexual Function Assessment -- Validated Questionnaires in Male Sexual Function Assessment -- Evaluation of the Female with Sexual Dysfunction -- Evaluation of Male Sexual Dysfunction -- The Impact of Cancer on the Partner?s Sexuality -- Gay and Lesbian Patients with Cancer -- The Impact of a Cancer Diagnosis on Sexual Health -- Breast Cancer -- Gynecological Cancers -- Pelvic Surgery for Urological Cancers -- Pelvic Radiation in Men -- Pelvic Radiation in Women -- Impact of Chemotherapy and Hormone Therapy on Female Sexual Health -- Impact of Androgen Deprivation Therapy on Men?s Sexual Health -- Colorectal Cancer -- Stem Cell Transplant --Sexual Health in the Terminally Ill -- Survivorship: An Overview -- Nutriceuticals in Sexual Health -- Medical Treatments for Sexual Problems in Women -- Surgical Treatments for Sexual Problems in Women -- Sex Therapy in Female Sexual Dysfunction -- Erectile Dysfunction: Pharmacological Therapy -- Erectile Dysfunction: Devices -- The Management of Premature Ejaculation -- Testosterone Therapy in the Male Cancer Patient -- Sex Therapy in Male Sexual Dysfunction -- Restoring Intimacy in Relationships Affected by Cancer -- Dating and Disclosure for Cancer Survivors.
  • Peyton Rous: A Centennial Tribute to the Founding Father of Cancer Virology -- Viruses and Cancer: A Historical Perspective - HBV and Prevention of a Cancer -- Virus-Mediated Cell Proliferation -- Viral-Encoded Genes and Cancer -- Oncogenic Viruses and Cancer Transmission -- DNA Viruses and Cancer: Taking a Broader Look -- Herpesviruses and Cancer -- Lymphocryptoviruses: EBV and Its Role in Human Cancer -- Nonhuman Primate Gamma-herpesviruses and Their Role in Cancer -- Rhadinoviruses: KSHV and Associated Malignancies -- Retroperitoneal Fibromatosis Herpesvirus and Kaposi's Sarcoma-Like Tumors in Macaques -- Murine Gammaherpesvirus-Associated Tumorigenesis -- Marek's Disease Virus-Induced T-Cell Lymphomas -- Polyomaviruses and Cancer -- Polyomavirus SV40: Model Infectious Agent of Cancer -- BK Polyomavirus and Transformation -- Polyomavirus JC and Human Cancer: Possible Role of Stem Cells in Pathogenesis -- Merkel Cell Polyomavirus -- Human Papillomaviruses and Cancer -- Tumorigenesis by Adenovirus Type 12 E1A -- Overview of Hepatitis Viruses and Cancer -- Hepadnaviruses and Hepatocellular Carcinoma -- Hepatitis C Virus and Hepatocellular Carcinoma -- Human and Animal Retroviruses: HIV-1 Infection Is a Risk Factor for Malignancy -- HTLV-1 and Oncogenesis -- Human T-Cell Leukemia Virus Type 2 (HTLV-2) Biology and Pathogenesis -- Mechanisms of Oncogenesis by Avian and Murine Retroviruses -- Rous Sarcoma Virus: Contributions of a Chicken Virus to Tumor Biology, Human Cancer Therapeutics, and Retrovirology -- Mouse Mammary Tumor Virus and Cancer -- Jaagsiekte Sheep Retrovirus and Lung Cancer -- Small RNAs and Their Role in Herpesvirus-Mediated Cancers -- Viral Malignancies in HIV-Associated Immune Deficiency.
  • Also available: Print – 2014
    Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.
  • "According to the American Cancer Society report, "by 2030, the global cancer burden is expected to nearly double, growing to 21.4 million cases and 13.2 million deaths." Early diagnosis improves treatment efficacy and quality of life as well as reduces the cost for disease management. However, the development of molecular markers for early cancer diagnosis is always a challenge. Some fundamental principles in medical practice are (a) primum non nocere, a Latin phrase that means "first, do no harm," and (b) even when a patient's prognosis is poor, the physician must do his or her best for improving quality of the patient's life. Therefore, noninvasive or minimally invasive cancer diagnostic methods are of choice that can avoid complications of biopsy and other unfavorable impacts on patient's health. In this context, patients' easily collectable biospecimens such as blood, serum, plasma, urine, stool, sputum, saliva, etc., based molecular markers having high specificity and sensitivity in early diagnosis are emerging rapidly and in many instances such markers are also emerging as next-generation prognostic indicators and personalized therapeutics and precision medicine. Several patents have been filed and/or granted on such markers, and a number of health-care companies and authorities currently use or focus on the development of such markers. The significance of clinical validation approaches of several markers has been discussed in different chapters. This book, Cancer Biomarkers: Noninvasive Early Diagnosis and Prognosis, reflects the rapid expansion of important scientific, technological, clinical, and translational aspects of noninvasive or minimally invasive molecular cancer biomarkers and their applications along with other conventional markers"-- Provided by publisher.
  • Cancer cachexia 2012
  • Cancer cachexia 2013
    Future Med
    Cancer cachexia / Josep M. Argilés & Sílvia Busquets -- Prevalence and clinical features of cancer cachexia / Neil Johns, Richard J.E. Skipworth, Kenneth C.H. Fearon & James A. Ross -- Pathogenesis of cancer cachexia / Fabio Penna, Francesco M. Baccino & Paola Costelli -- Current medications for cancer cachexia / Clelia Madeddu, Antonio Macciò, Maria Chiara Cau, Roberto Serpe & Giovanni Mantovani -- Latest developments in cachexia drug discovery : clinical trials / Josep M. Argilés, Francisco Javier López-Soriano, Britta Stemmler & Sílvia Busquets -- Comorbidities and prognosis / Alessandro Laviano, Gianluca Di Lazzaro Giraldi & Serena Rianda -- Index.
  • "Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1), Hepatitis C virus (HCV), Epstein-Barr virus (EBV), Human papilloma virus (HPV), Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV), Human immunodeficiency virus (HIV/AIDS), Oncolytic viruses. This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies"--Provided by publisher.
  • Xenotransplantation of breast cancers -- Feeder layers: Co-culture with nonneoplastic cells -- Drug design and testing: Profiling of antiproliferative agents for cancer therapy using a cell-based methyl-[3h]-thymidine incorporation assay -- Transfection and DNA-mediated gene transfer -- Analysis of drug interactions -- Development of rituximab-resistant B-NHL clones: An in vitro model for studying tumor resistance to monoclonal antibody-mediated immunotherapy -- Proteomic evaluation of cancer cells: Identification of cell surface proteins -- Measuring gene expression from cell cultures by quantitative reverse-transcriptase polymerase chain reaction -- Expression analysis of homeobox genes in leukemia/lymphoma cell lines -- Flow cytometric DNA analysis of human cancers and cell lines -- Angiogenesis assays -- Cell migration and invasion assays -- Molecular breakpoint analysis of chromosome translocations in cancer cell lines by long distance inverse-PCR -- Measurement of DNA damage in individual cells using the Single Cell Gel Electrophoresis (Comet) assay -- Purification of annexin V and its use in the detection of apoptotic cells -- Real-time cytotoxicity assays -- Differential staining cytotoxicity assay: A review -- Cell sensitivity assays: The ATP-based tumor chemosensitivity assay -- Cell sensitivity assays: The MTT assay -- Cellular chemosensitivity assays: An overview -- Isolation of endothelial cells from human tumors -- Isolation of inflammatory cells from human tumours -- Establishment and culture of leukemia-lymphoma cell lines -- Isolation and culture of ovarian cancer cells and cell lines -- Isolation and culture of squamous cell carcinoma lines -- Isolation and culture of melanoma and naevus cells and cell lines -- Isolation and culture of colon cancer cells and cell lines -- Generation of lung cancer cell line variants by drug selection or cloning -- Quality assurance and good laboratory practice -- Elimination of mycoplasmas from infected cell lines using antibiotics -- Detecting mycoplasma contamination in cell cultures by polymerase chain reaction -- Cell culture contamination -- Cytogenetic analysis of cancer cell lines -- Online verification of human cell line identity by STRDNA typing -- Characterization and authentication of cancer cell lines: An overview -- Storage of cell lines -- Principles of cancer cell culture -- Cancer biology.
  • Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past decade, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.
  • Clinical strategies for cancer treatment: the role of drugs / Bruce Chabner -- Preclinical aspects of cancer drug discovery and development / Paula Krosky ... [et al.] -- Pharmacokinetics / Jerry Collins, Jeffrey G. Supko -- Infertility after cancer chemotherapy / Angela Bradbury, Richard L. Schilsky -- Carcinogenesis of anticancer drugs / Laawrence S. Blaszkowsky, Charles Erlichman -- Antifolates / Brian P. Monahan, Carmen J. Allegra -- 5-Fluoropyrimidine / Jean L. Grem -- Cytidine analogues / David P. Ryan, Rocio Garcia-Carbonero, Bruce A. Chabner -- Purine antimetabolites / Kenneth R. Hande -- Hydroxyurea / Luis Paz-Ares, Ross C. Donehower, Bruce A. Chabner -- Antimicrotubule agents / Eric K. Rowinsky -- Clinical and high-dose alkylating agents / Kenneth D. Tew, O. Michael Colvin, Roy B. Jones -- Nonclassic agents / Henry S. Friedman, Steven D. Averbuch, Joanne Kurtzberg -- Cisplatin, Carboplatin, and oxaliplatin / Eddie Reed -- Bleomycin / John s. Lazo, Bruce A. Chabner -- Antitumor antibiotics / Edwin W. Willems, Kees Nooter, Jaap Verweij -- Topoisomerase I-targeting drugs / Alex Sparreboom, William C. Zamboni -- Anthracyclines and anthracenediones / James H. Doroshow -- Topoisomerase II inhibitors: the epipodophyllotoxins, acridines, and ellipticines / Yves Pommier, François Goldwasser -- Asparaginase / Bruce A. Chabner, Alison M. Friedmann -- Delivering anticancer drugs to brain tumors / Maciej M. Mrugala, Tracy T. Batchelor, Jeffrey G. Supko -- Food and drug administration role in oncology product development / Thomas G. Roberts Jr. -- Central venous catheters: care and complications / Rachel P. Rosovsky, David J. Kuter -- Pharmacogenetics / Jeanne Fourie, Robert B. Diasio -- New targets for anticancer therapeutics / A. Dimitrios Colevas ... [et al.] -- Bisphosphonates / Matthew R. Smith -- Thalidomide and its analogs for the treatment of hematologic malignancies, including multiple myeloma, and solid tumors / Paul Richardson ... [et al.] -- Inhibitors of tumor angiogenesis / Anaadriana Zakarija, William J. Gradishar -- Proteasome inhibitors / Owen A. O'Connor -- Molecular targeted drugs and growth factor receptor inhibitors / Jeffrey W. Clark -- Antibody therapies of cancer / David A. Scheinberg ... [et al.] -- Interferons / Daniel J. Lindner ... [et al.] -- Adoptive cellular therapies / Carl H. June -- Cancer vaccines / Glenn Dranoff -- Hematopoietic growth factors / William P. Petros -- Interleukins / Gheath Alatrash ... [et al.] -- Harmonal therapy for breast cancer / Peter F. Lebowitz, Sandra M. Swain.
  • Clinical strategies for cancer treatment: the role of drugs -- Target identification and drug discovery -- Clinical drug development and marketing approval -- Principles of pharmacokinetics -- Delivering anticancer drugs to brain tumors -- Pharmacogenetics -- Physical barriers to drug delivery -- Antifolates -- 5-fluoropyrimidines -- Cytidine analogues -- Purine antimetabolites -- Hydroxyurea -- Antimitotic drugs -- Alkylating agents -- Platinum analogues -- Bleomycin and other antitumor antibiotics -- Topoisomerase I-targeting drugs -- Topoisomerase II inhibitors: anthracyclines -- Topoisomerase II inhibitors: the epipodophyllotoxins -- Asparaginase -- Proteasome inhibitors -- Histone deacetylase inhibitors in oncology -- Differentiating agents -- Arsenic trioxide -- Antibodies -- Inhibitors of tumor angiogenesis -- Epidermal growth factor receptor inhibitors -- HER2 inhibitors -- Molecular targeted drugs -- Signaling inhibitors: IGFR, PI3K pathway, embryonic signaling inhibitors, and mitotic kinase inhibitors -- Cytokine therapy for cancer -- Cancer vaccines -- Adoptive cellular therapies -- Thalidomide and its analogs in the treatment of hematologic malignancies, including multiple myeloma, and solid tumors -- Hormonal therapy of breast cancer -- Hormone therapy for prostate cancer -- Drug therapy of pain in cancer patients -- Hematopoietic growth factors -- Antinausea medications -- Bisphosphonates and other bone-targeted therapies -- Intravenous access and catheter management -- Late effects of cancer chemotherapy -- Infertility after cancer chemotherapy.
  • A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.
  • Also available: Print – 2007
    Historical perspective and evolving concerns for human research / Bernard Lo and Nesrin Garan -- Cancer trials and the Institutional Review Board (IRB) / Scott Kurtzman and Zita Lazzarini -- NCI's cancer therapy evaluation program: a commitment to treatment trials / Jeffrey S. Abrams, Anthony Murgo and Michaele C. Christian -- Practical guide for cancer clinical investigators / Steven Hirschfeld -- The role of cooperative groups in cancer clinical trials / Ann M. Mauer, Elizabeth S. Rich and Richard L. Schilsky -- The advocate role in clinical study development and partnering with patient advocates in your local institution / Barbara Parker -- The National Breast Cancer Coalition: setting the standard for advocate collaboration in clinical trials / Fran Visco -- The role of the principal investigator in cancer clinical trials / Stanley P.L. Leong -- The audit process and how to ensure a successful audit / Y. Nancy You, Lisa Jacobs, Elizabeth Martinez and David M. Ota -- The privacy rule (HIPAA) as it relates to clinical research / John M. Harrelson and John M. Falletta -- The Commission on Cancer, American College of Surgeons' response to HIPAA / E. Greer Gay -- Ethical and legal issues in the conduct of cancer clinical trials / Gerianne J. Sands and Peggy A. Means -- The role of the Office of Research Integrity in cancer clinical trials / Peter Abbrecht, Nancy Davidian, Samuel Merrill and Alan R. Price -- Strategies for the administration of a clinical trial infrastructure: lessons from a comprehensive cancer center / Leonard A. Zwelling and Carleen A Brunelli -- The clinical research process: building a system in harmony with its users / Greg Koski -- Cancer research and clinical trial in action: an important exercise before you embark on your study / Stanley P.L. Leong, Larry Carbone and Scott Kurtzman.
  • [Publisher-supplied data] Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients. Cancer Cytogenetics: Methods and Protocols presents eminently practical key cytogenetic and FISH techniques for every stage of diagnostic service. Experts in the field describe detailed cytogenetic analysis methods, fluorescence in situ hybridization and array methods currently being applied to investigate and diagnose different varieties of cancer. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory protocols. The authors of the various chapters have also provided extensive notes to guide individuals who are new to these methods through the pitfalls that bedevil all such testing. Authoritative and accessible, Cancer Cytogenetics: Methods and Protocols serves as an ideal guide to scientists of all backgrounds, allowing them to either establish new techniques in their laboratories or find the different variations of standard methods helpful in improving their results.
  • Also available: Print – 2006
  • Cancer epidemiology v. 1-2, 2009
    Springer Protocols
    v. 2, 2009 Springer Protocols
    v. 1. Host susceptibility factors -- v. 2. Modifiable factors.
  • Cancer epigenetics 2009
    Also available: Print – 2009
    The role of epigenetics in cancer / Trygve O. Tollefsbol -- DNA hypomethylation in cancer / Peter L. Molloy -- DNA hypermethylation in oncogenesis / J. Tyson DeAngelis ... [et al.] -- Imprinting alterations in tumorigenesis / Jeremiah Bernier-Latmani and Phillip Shaw -- Proteins that modulate DNA methylation aberrations in cancer / Sabrina L. Walthall ... [et al.] -- The role of DNA methylation in cancer progression / Sang-Woon Choi and Simonetta Friso -- Alterations in histone acetylation in tumorigenesis / Sabita N. Saldanha and Trygve O. Tollefsbol -- Histone methylation and the initiation of cancer / Shi Huang -- The role of sirtuins in aging and tumorigenesis / Xiaohong Zhang ... [et al.] -- Proteins that alter histone modifications in cancer / Ada Ao and Jianrong Lu -- Dietary and environmental influences on histone modifications in cancer / Sabita N. Saldanha ... [et al.] -- Noncoding RNAs in cancer / Maciej Szymanski and Jan Barciszewski -- Cancer-linked DNA hyper- and hypomethylation: chromosome positional effects / Melanie Ehrlich -- Chromatin remodeling and cancer / Sari Pennings and Richard R. Meehan -- Poly-ADP-ribosylation in cancer / Rajeshwar N. Sharan -- Polycomb group proteins in tumorigenesis / Hanneke E.C. Niessen and Jan Willem Voncken -- Cancer and aging: the epigenetic connection / Craig A. Cooney -- DNA methylation in tumor diagnosis / Kavitha Ramachandran, Edna Gordian, and Rakesh Singal -- DNA methylation profiles as prognostic markers for cancer / Sam Thiagalingam and Panagiotis Papageorgis -- Diagnosing cancer using histone modification analysis / Mukesh Verma and Deepak Kumar -- Histone modifications in cancer biology and prognosis / Matthew A. McBrian, David B. Seligson, and Siavash K. Kurdistani -- Histone deacetylase inhibitors in cancer therapy / Aaron M. Sargeant ... [et al.] -- Methylation changes in neoplasia: diagnostic and therapeutic implications / Eleftheria Hatzimichael, Justin Stebbing, and Tim Crook -- Clinical trials and approved drugs for epigenetic cancer therapy / Debby M.E.I. Hellebrekers and Manon van Engeland -- Future directions in epigenetic cancer research / Jacob Peedicayil.
  • Cancer gene therapy 2005
    Cancer gene therapy : historical perspective / Malcolm K. Brenner -- The genetic basis of cancer / Akseli Hemminki and Kari Hemminki -- Tumor suppressor gene replacement for cancer / Jack A. Roth and Susan F. Grammer -- Antisense technology / Ruiwen Zhang and Hui Wang -- Cancer therapeutic applications of ribozymes and RNAi / Lisa Scherer and John J. Rossi -- Fusogeneic membrane glycoproteins for cancer gene therapy : a better class of killer / Andrew Bateman ... [et al.] -- Suicide gene therapy / Caroline J. Springer and Ion Niculescu-Duvaz -- Molecular chemotherapy approaches / Daniel H. Palmer and David J. Kerr -- Genetic immunotherapy approaches / Denise R. Shaw and Albert F. LoBuglio -- Immunotherapy of cancer by dendritic cell-targeted : gene transfer / Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper -- Dendritic cells / Weiping Zou, Shuang Wei and Tyler J. Curiel -- Polynucleotide immunization for cancer therapy / Theresa V. Strong -- Development of oncolytic replication-competent herpes simplex virus vectors: the G207 paradigm / Tomoki Todo and Samuel D. Rabkin -- Development of oncolytic adenoviruses : from the lab bench to the bedside / John A. Howe, Robert Ralston, and Murali Ramachandra -- Conditionally replicating adenoviruses for cancer treatment / Ramon Alemany -- Reovirus as an oncolytic agent / Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee -- Antiangiogenic gene therapy of cancer / Steve Gyorffy ... [et al.] -- Proapoptotic strategy in cancer gene therapy / David H. Holman ... [et al.] -- Antimetastasis / Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung -- Antimetastatic gene therapy : prostate cancer theory to therapy / Thomas A. Gardner ... [et al.] -- Drug-resistance gene transfer as an antitumor strategy / Colin L. Sweeney and R. Scott McIvor -- Chemosensitization / Per Eystein Lønning -- Radiosensitization by gene therapy / Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum -- Nonviral vector systems for cancer gene therapy / Greg F. Walker and Ernst Wagner -- Viral vectors for cancer gene therapy / Joanne T. Douglas and David T. Curiel -- Bacterial systems for tumor-specific gene therapy / J. Martin Brown ... [et al.] -- Molecular imaging of cancer gene therapy / Harvey R. Herschman -- Cancer-related gene therapy clinical trials / Robert J. Korst and Ronald G. Crystal -- Regulatory aspects in the development of gene therapies / Rosemarie Aurigemma ... [et al.].
  • Cancer genetics 2010
    Also available: Print – 2010
  • Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.
  • Reciprocal subtraction differential RNA display (RSDD) : an efficient technology for cloning differentially expressed genes / Devanand Sarkar, Dong-chul Kang, and Paul B. Fisher -- Cloning differentially expressed genes using rapid subtraction hybridization (RaSH) / Habib Boukerche ... [et al.] -- The application of differential display as a gene profiling tool / Ken Chien-Neng Chang ... [et al.] -- Serial analysis of gene expression (SAGE) / Fred van Ruissen and Frank Baas -- Gene expression profile analysis of tumors / Katia Basso and Riccardo Dalla-Favera -- cDNA microarray and bioinformatic analysis of nuclear factor [kappa]B related genes in squamous cell carcinoma / Zhong Chen ... [et al.] -- Gene profiling uncovers retinoid target genes / Yan Ma ... [et al.] -- Complete open reading frame (C-ORF) technique : rapid and efficient method for obtaining complete protein coding sequences / Dong-chul Kang and Paul B. Fisher -- Chromatin immunoprecipitation assays : molecular analysis of chromatin modification and gene regulation / Piyali Dasgupta and Srikumar P. Chellappan -- Manipulating genes and gene copy number by bacterial artificial chromosome transfection / Stephanie F. Phelps, Sharon Illenye, and Nicholas H. Heintz -- Molecular cytogenetic applications in analysis of the cancer genome / Pulivarthi H. Rao, Subhadra V. Nandula, and Vundavalli V. Murty -- Monitoring methylation and gene expression in cancer / Hetty Carraway and James Herman -- The use of phage display peptide libraries for basic and translational research / Renee Brissette and Neil I. Goldstein -- Yeast and mammalian two-hybrid systems for studying protein-protein interactions / Shu-ichi Matsuzawa and John C. Reed -- Ribonomic and short hairpin RNA gene silencing methods to explore functional gene programs associated with tumor growth arrest / Timothy E. Baroni ... [et al.] -- Surface-epitope masking (SEM) : an immunological subtraction approach for developing monoclonal antibodies targeting surface-expressed molecules / Neil I. Goldstein and Paul B. Fisher -- Approaches for monitoring signal transduction changes in normal and cancer cells / Paul Dent ... [et al.] -- PKR in innate immunity, cancer, and viral oncolysis / Siddharth Balachandran and Glen N. Barber -- Analysis of transformation and tumorigenicity using mouse embryonic fibroblast cells / Hong Sun and Reshma Taneja -- Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells / Hong Sun, Neriman Tuba Gulbagci, and Reshma Taneja -- Reverse phase protein microarrays for monitoring biological responses / Virginia Espina ... [et al.] -- Protein crystallization / Champion Deivanayagam, William J. Cook, and Mark R. Walter.
  • This is the second edition of a practice-oriented, well-illustrated manual on the microscopic grading of tumors. After an introduction on the history and basic tenets of tumor grading, subsequent chapters focus on specific organ systems. In each case, the most widely used system for grading common tumors is presented and discussed. Throughout, careful attention is paid to the principles of microscopic tumor grading, ancillary methods to improve grading, and the latest techniques used in evaluating tumors and formulating prognosis.
  • Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.
  • Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.
  • Also available: Print – 2011
    Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
  • This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗ℓ The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
  • This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies.Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy.Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.
  • This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Introduction / W. Archie Bleyer ... [et al.] -- History of adolescent oncology / Cameron K. Tebbi -- Epidemiology and etiology of cancer in adolescents and young adults / Jillian M. Birch and W. Archie Bleyer -- Access to care before and during therapy / Karen H. Albritton and Tim Eden -- Older adolescents and young adults with cancer, and clinical trials: lack of participation and progress in North America / W. Archie Bleyer, Troy Budd, and Michael Montello -- Acute lymphoblastic leukemia / James Nachman, Giuseppe Masera, and W. Archie Bleyer -- Acute myelogenous leukemia / Ursula Creutzig and William G. Woods -- Hodgkin lymphoma / Tanya M. Trippett ... [et al.] -- Non-hodgkin lymphoma / Catherine Patte, W. Archie Bleyer, and Mitchell S. Cairo -- Central nervous system tumors in adolescents and young adults / David A. Walker ... [et al.] -- Soft-tissue sarcomas / Karen H. Albritton, Andrea Ferrari, and Michela Casanova -- Bone sarcomas / Michael S. Isakoff ... [et al.] -- Malignancies of the ovary / Jubilee Brown, Thomas Olson, and Susan Sencer -- Testicuar tumors / John W. Cullen and Robert Fallon -- Non-germ-cell genitourinary tract tumors / Michael Leahy and W. Archie Bleyer -- Thyroid cancer / Steven G. Waguespack and Samuel A. Wells -- Malignant melanoma / Cynthia E. Herzog, W. Archie Bleyer, and Alberto S. Pappo -- Breast cancer / Marianne Phillips, Banu Arun, and W. Archie Bleyer -- Liver tumors / Marcio H. Malogolowkin, Arthur Zimmermann, and Jack Plaschkes -- Colorectal cancer / Wayne L. Furman, D. Ashley Hill, and Michael LaQuaglia -- Models of care and specialized units / Ian Lewis and Sue Morgan -- Drug compliance by adolescent and young adult cancer patients: challenges for the physician / Benjamin Gesundheit ... [et al.] -- Psychological support for adolescents and young adults / Christine Eiser and Aura Kuperberg -- Psychosocial support / Brad J. Zebrack, Mark A. Chesler, and Anthony Penn -- Health-related quality of life / Ernest R. Katz ... [et al.] -- Rehabilitation and exercise / Marilyn J. Wright -- Adolescent and young adult cancer survivors: late effects of treatment / Smita Bhatia ... [et al.] -- Ethical issues for the adolescent and young adult cancer patient: assent and end-of-life care / Susan Shurin and Eric Kodish -- Access to care after therapy / Karen E. Kinahan ... [et al.] -- Future health of survivors of adolescent and young adult cancer / Melissa M. Hudson and Kevin C. Oeffinger -- Information and resources for young adults and adolescents with cancer / David R. Freyer and Leonard J. Mattano -- Making ends meet: financial issues from the perspectives of patients and their healthcare team / David R. Freyer and Ronald D. Barr -- Challenges and opportunities - the way ahead / W. Archie Bleyer ... [et al.].
  • Also available: Print – 2007
  • This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer management. The chemotherapy section of the book is updated to include the newest drugs as well as those currently in development. Organized by drug class, this section provides the latest information on most drugs, including their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance.
  • Cancer medicine. 8. 8th ed. 2010
    STAT!Ref, Limited to 7 simultaneous users
    Also available: Print – 2010
  • Print Material
    Cancer biology -- Cancer immunology -- Cancer etiology -- Cancer epidemiology, prevention, and screening -- Clinical trials and outcomes assessment -- Cancer pathology -- Imaging -- Surgical oncology -- Radiation oncology -- Medical oncology -- Chemotherapy -- Chemotherapeutic agents -- Biotherapeutics -- Endocrine therapy -- Gene therapy -- Bone marrow transplantation -- Psycho-oncology -- Oncology nursing -- Cancer rehabilitation medicine -- Multidisciplinary management -- Pain and palliation -- Societal oncology -- Central nervous system -- The Eye -- Endocrine glands -- Head and neck -- The Thorax -- Gastrointestinal tract -- Genitourinary tract -- Female reproductive organs -- The Breast -- The Skin -- Bone and soft tissue -- Hematopoietic system -- Neoplasms in AIDS --- Unknown primary site -- Pediatric oncology -- Complications of cancer and their treatment -- Infection in the cancer patient -- Oncologic emergencies -- Oncology and informatics.
  • Also available: Print – 2007
  • Basic principles of radiation therapy of cancers / Laurence Court and Radhe Mohan -- Biological principles of radiosensitization / Vikas Bhardwaj ... [et al.] -- Principles and applications of hyperthermia combined with radiation / Mark Hurwitz -- Synthesis and surface modification of nanomaterials for tumor targeting / Glenn Goodrich -- Safety concerns for nanomaterials in nanomedicinal applications / Qingxin Mu ... [et al.] -- Imaging with nanoparticles / Amit Joshi -- Optical microscopy of plasmonic nanoparticles / Varun P. Pattani and James Tunnell -- X-ray fluorescence computed tomography imaging of nanoparticles / Bernard L. Jones and Sang Hyun Cho -- Gold nanoparticle-mediated radiosensitization / Devika B. Chithrani -- Quantification of gold nanoparticle-mediated radiation dose enhancement / Sang Hyun Cho and Bernard L. Jones -- Semiconductor nanomaterials for radiotherapy / Ke Sheng -- Radioactive gold nanoparticle for tumor therapy / Raghuraman Kannan, Kattesh V. Katti, and Cathy Cutler -- Nanoparticles for the selective radioprotection of normal tissues / Jacob M. Berlin and Kathy A. Mason -- Gold nanoparticle-mediated hyperthermia in cancer therapy / Dev K. Chatterjee and Sunil Krishnan -- Magnetic resonance thermometry imaging for gold nanoparticle-mediated thermal therapy / R. Jason Stafford and John D. Hazle -- Modeling of plasmonic heat generation from gold nanoparticles / Francisco Reynoso and Sang Hyun Cho -- Carbon nanotubes for thermal therapy / Ravi N. Singh ... [et al.] -- Regulatory issues for clinical translations / J. Donald Payne -- Clinical translations of nanotechnology : present and future outlook / Dev K. Chatterjee, Sang Hyun Cho, and Sunil Krishnan.
  • Overview -- Diagnostic studies -- Neurologic symptoms -- Direct complications of cancer -- Indirect complications of cancer -- Complications of cancer therapy -- Neurologic complications of specific malignancies.
  • Cancer of the Skin, edited by Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is your complete, multimedia guide to early diagnosis and effective medical and surgical treatment of melanoma and other skin cancers. Thoroughly updated with 11 new chapters, this broad-based, comprehensive reference provides you with the latest information on clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other timely topics. A new, multi-disciplinary team of contributors and editors comprised of leading experts in this field offers truly diverse perspectives and worldwide best practices.
  • The book covers the complete field of testis cancer including the germ cell tumors and the stromal tumors, from epidemiology to new chemotherapeutic agents and schedules, throughout genetic features, risk factors, risk adapted treatments, role of different types of surgery and special clinical situations. Special attention is focused on fertility issues, late effects of the primary therapy and the economical aspects of the different treatment policies. As a result of the third Consensus Conference, a consensual follow-up can be devised and a chapter dedicated to this controversial and not yet defined matter.
  • Cancer pain 2013
    Cancer remains a major challenge for medicine and it continues to claim lives and cause great suffering. Pain is a symptom experienced by most cancer patients regardless of disease stage, and less than 50% of cancer pain patients achieve effective pain and symptom control though available therapies. If these therapies are utilized correctly, many more patients can achieve effective control. While opioids are still seen as the mainstay of cancer pain treatment, it is necessary to examine whether this treatment strategy still holds true in the 21st century. Cancer Pain provides a comprehensive, up-to-date, practical guide to the management of pain in cancer patients. The book provides a clear, concise explanation of cancer pain syndromes, a modern understanding of the pathophysiological mechanism and an overview of recent developments in creating pre-clinical cancer pain models. It offers the reader the wide and improved options for management of cancer pain in clinical practice, including the use of opioid and non-opioid drugs, and defines the role of non-pharmacological methods for pain control. Cancer Pain also provides an overview of the latest developments in the management of cancer, which have major implications for the current and future thinking in cancer pain treatment strategy. This text is an invaluable resource for doctors, trainees and clinical nurse specialists in palliative medicine and oncology, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of cancer pain and the tools available to alleviate it.
  • Cancer prevention 2007
    Also available: Print – 2007
  • Combining computational and experimental methods for identifying molecular targets of phytochemicals / Ann M. Bode and Zigang Dong -- Common methods used for the discovery of natural anticancer compounds / Min Tang ... [et al.] -- Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals / Francisco Fuentes ... [et al.] -- Methods to analyze chemopreventive effect of silibinin on prostate cancer biomarkers protein expression / Gagan Deep, Swetha Inturi, and Rajesh Agarwal -- Approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer / Gary D. Stoner ... [et al.] -- Use of mouse models for lung cancer chemoprevention studies / Yian Wang ... [et al.] -- Azoxymethane plus dextran sulfate sodium-induced mouse colon cancer model for the study of dietary chemoprevention of inflammation-associated carcinogenesis / Ha-Na Lee, Hye-Won Yum, and Young-Joon Surh -- Use of seahorse extracellular flux analyzer in mechanistic studies of naturally occurring cancer chemopreventive agents / Michelle B. Moura ... [et al.] -- Utilizing RNA-seq to define phytochemical-induced alterations in insulin and IGF-regulated transcriptomes / Heather Beckwith and Douglas Yee -- Ex vivo use of keratinocytes from adult mice to define stem cell activities in cancer research / Rebecca J. Morris ... [et al.] -- Quantitation of acetaldehyde-DNA adducts : biomarkers of alcohol consumption / Silvia Balbo and Stephen S. Hecht -- Imaging tools in discovery and development of phytochemical chemopreventive agents / Marna Ericson -- Designing the chemoprevention trials of tomorrow : applying lessons learned from past definitive trials / Karen Colbert Maresso and Ernest Hawk.
  • Also available: Print – 2009
  • Also available: Print – v. 1-2., 2008
  • Also available: Print – v. 1-2, 2005.
  • The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging -- Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas -- Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • Proteomics technologies -- Cell signaling proteomics -- Tumor proteomics -- Bioinformatics and regulatory aspects of proteomics.
  • Cancer stem cells : historical perspectives and lessons from leukemia / Christopher R. Cogle -- Cancer stem cells in breast cancer / Jenny E. Chu and Alison L. Allan -- Cancer stem cells in brain cancer / Xin Wang, Chitra Venugopal, and Sheila K. Singh -- Cancer stem cells in colorectal cancer / Mauro Biffoni, Eros Fabrizi, and Lucia Ricci-Vitiani -- Cancer stem cells in pancreatic cancer / Jorge Dorado, Alicia G. Serrano, and Christopher Heeschen -- Cancer stem cells in prostate cancer / Paula Kroon ... [et al.] -- Cancer stem cells in melanoma / Ping Jin ... [et al.] -- Cancer stem cells in lung cancer / Jun Shen and Feng Jiang -- Cancer stem cells in ovarian cancer / Fang Fang ... [et al.] -- Cancer stem cells in hepatocellular cancer / Russell C. Langan and Itzhak Avital -- Cancer stem cells in head and neck cancer / Mark E.P. Prince and Samantha J. Davis -- Relationship between regulatory pathways in pluripotent stem cells and human tumors / Olga Gaidarenko and Yang Xu -- Influence of the embryonic microenvironment on tumor progression / Daniela Quail ... [et al.] -- The epithelial-to-mesenchymal transition and cancer stem cells / Jonas Fuxe -- Application of stem cell assays for the characterization of cancer stem cells / Pamela M. Willan and Gillian Farnie -- Zebrafish as a model to study stem cells in development, disease, and cancer / Viviana Anelli, Cristina Santoriello, and Marina C. Mione -- Imaging cancer stem cells / Paula Foster -- Mouse models for studying normal and cancer stem cells / David A. Hess -- Cancer stem cells and disease prognosis / Zeshaan A. Rasheed, Jeanne Kowalski, and William H. Matsui -- Mechanisms of radioresistance in cancer stem cells / Cleo Y-F Lee and Maximilian Diehn -- The role of ABC transporters in cancer stem cell drug resistance / Vera S. Donnenberg, Ludovic Zimmerlin, and Albert D. Donnenberg -- Resistance to endocrine therapy in breast cancer : are breast cancer stem cells implicated? / Ciara S. O'Brien ... [et al.] -- Future directions : cancer stem cells as therapeutic targets / Alysha K. Croker and Alison L. Allan -- Final thoughts : complexity and controversy surrounding the "cancer stem cell" paradigm / Craig Gedye, Richard P. Hill, and Laurie Ailles.
  • Also available: Print – 2011
  • Cancer survivors: a physician's perspective / Patricia A. Ganz -- Cancer survivorship: a nursing perspective / Susan Leigh -- Oncology social work for survivorship / Patricia Fobair -- Survivorship research: past, present, and future / Julia H. Rowland -- Surveillance after primary therapy / Craig C. Earle -- Late effects of cancer treatments / Noreen M. Aziz -- Medical and psychosocial issues in childhood cancer survivors / Smita Bhatia ... [et al.] -- Medical and psychosocial issues in Hodgkin's disease survivors / Jon Håvard Loge and Stein Kaasa -- Medical and psychosocial issues in testicular cancer survivors / S.D. Fosså, L.B. Travis, and A.A. Dahl -- Medical and psychosocial issues in gynecologic cancer survivors / Karen Basen-Engquist and Diane C. Bodurka -- Medical, psychosocial, and health-related quality of life issues in breast cancer survivors / Julie Lemieux, Louise J. Bordeleau, and Pamela J. Goodwin -- Medical and psychosocial issues in prostate cancer survivors / Tracey L. Krupski and Mark S. Litwin -- Physical and psychosocial issues in lung cancer survivors / Linda Sarna, Frederic W. Grannis, and Anne Coscarelli -- Cancer survivorship issues in colorectal cancer / Clifford Y. Ko and Patricia A. Ganz -- Medical and psychosocial issues in transplant survivors / Karen L. Syrjala ... [et al.] -- Cancer survivorship issues in older adults / Karim S. Malek and Rebecca A. Silliman -- Second malignancies after radiation treatment and chemotherapy for primary cancers / Lydia B. Zablotska, Matthew J. Matasar, and Alfred I. Neugut -- Psychosocial rehabilitation in cancer care / Richard P. McQuellon and Suzanne C. Danhauer -- Reproductive complications and sexual dysfunction in cancer survivors / Leslie R. Schover -- The employment and insurance concerns of cancer survivors / Barbara Hoffman -- Cancer advocacy / Ellen L. Stovall -- The survivorship care plan: what, why, how, and for whom / Craig C. Earle ... [et al.]
  • Cancer systems biology 2010
    A roadmap of cancer systems biology / Edwin Wang -- Network biology : the framework of systems biology / Jing-Dong Han -- Reconstructing gene networks using gene expression profiles / Mario Lauria and Diego di Bernardo -- Understanding cancer progression in protein interaction networks / Jinsheng Sun, Jie Li, and Edwin Wang -- From tumor genome sequencing to cancer signaling maps / Cong Fu and Edwin Wang -- Ubiquitin-mediated regulation of human signaling networks in normal and cancer cells / Cong Fu, Jie Li, and Edwin Wang -- MicroRNA regulation of networks of normal and cancer cells / Pradeep Kumar Shreenivasaiah, Do Han Kim, and Edwin Wang -- Network model of survival signaling in T-cell large granular lymphocyte leukemia / Ranran Zhang, Thomas P. Loughran Jr., and Réka Albert -- Cancer metabolic networks : metabolic pathways modelling and metabolomics in cancer research / Miroslava Cuperlovic-Culf -- Warburg revisited : modeling energy metabolism for cancer systems biology / Mathieu Cloutier -- Cancer gene prediction using a network approach / Xuebing Wu and Shao Li -- Cancer genomics to cancer biology / Maria Luz Jaramillo and Chabane Tibiche -- Epithelial-to-mesenchymal transition (EMT) : the good, the bad, and the ugly / Anne EG Lenferink -- Tumors and their microenvironments / Nicholas R. Bertos and Morag Park -- Tumor angiogenesis : cell-microenvironment interactions / Ally Pen, Danica B. Stanimirovic, and Maria J. Moreno -- Modeling tools for cancer systems biology / Wayne Materi and David S. Wishart -- Advanced visualization, analysis, and inference of biological networks using visANT / Zhenjun Hu -- Gene set and pathway-based analysis for cancer omics / Dougu Nam and Seon-Young Kim -- SH2 domain signaling network and cancer / Shawn S.-C. Li and Thamara K.J. Dayarathna -- Data sources and computational tools for cancer systems biology / Yun Ma, Pradeep Kumar Shreenivasaiah, and Edwin Wang.
  • pt. 1. Introduction and background -- pt. 2. Laboratory, clinical, data and educational resources -- pt. 3. Bioinformatics and systems biology analysis -- pt. 4. Diagnosis, clinical and treatment applications -- pt. 5. Perspectives and conclusions.
  • A Time Travel Journey Through Cancer Therapies -- Nanotechnology for Cancer Treatment: Possibilities & Limitations -- Vascular Targeting Approaches to Treat Cancer -- Tumor Immunotherapy by Utilizing a Double-Edged Sword Chemokines -- Cancer Biology: Some Causes for a Variety of Different Diseases -- Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on Nature of Tumor Stroma -- Cancer Cell Respiration: Hypoxia and pH in Solid Tumors -- Tumor Vasculature, EPR Effect, and Anticancer Nanomedicine: Connecting the Dots -- Pressure Gradients in Solid Tumors -- The ADAMs: New Therapeutic Targets for Cancer? -- Role of the Extracellular Matrix Enzyme Activities and Metastasis -- The Role of Non-Cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis -- Heterogeneity of Cancers and its Implication for Targeted Drug Delivery -- A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal Cancer -- Nanotherapeutics in Multidrug Resistance -- Stem Cells and Cancer -- Mechanisms of Metastasis -- Cancer-Specific Ligand/Receptor Interactions -- Targeting Drugs to Cancer: A Tough Journey to the Tumor Cell -- Long Circulation and Tumor Accumulation -- Convective and Diffusive Transport in Drug Delivery -- Intravital Real-Time Confocal Laser Scanning Microscopy for the in Situ Evaluation of Nanocarriers -- The EPR effect in Cancer Therapy -- In Vitro 3-dimensional Cancer Culture Model -- Complex Transport Around Tumor: Need for Realistic In Vitro Tumor Transport Model -- The Missing Components Today and the New Treatments Tomorrow.
  • Cancer treatment and research v. 122-, 2004-
  • Print Material
    Recounts the author's experience as a cancer patient. He was diagnosed with stage 2A Hodgkin lymphoma at age 30, and was cancer free in 2010, and five years later considered in complete remission.
  • Cancer-related fatigue (CrF) is increasingly recognized as a significant problem for patients with cancer at all stages, including those undergoing therapy and in remission. In fact, studies have shown that CrF causes patients more distress than pain, nausea, or vomiting and yet fatigue is still often undertreated and rarely studied. However, several new treatments such as are being investigated to determine the most effective ways to manage this debilitating symptom and improve patient quality of life. Cancer-Related Fatigue will provide a concise overview of this condition, with an evidence-based discussion of diagnosis, treatment, and long-term management.
  • Also available: Print – 2010
    Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.
  • Introduction -- Physiopathology and toxic drugs heart effects -- Radiotherapy heart effects -- Cardiac imaging technology in cardio-oncology -- Evaluation of the oncologic patient before, during and after chemotherapy -- What drug/what possible complication -- What cancer type/what possible drug -- what cancer/what possible complication -- Management (prevention/diagnosis/evaluation/therapy) of hypertension -- Management (prevention/diagnosis/evaluation/therapy) of coronary disease and thrombo-embolic complication -- Management (prevention/diagnosis/evaluation/therapy) of arrhythmic complication -- Management (prevention/diagnosis/evaluation/therapy) of systolic dysfunction.
  • Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.
  • The first of several satellite volumes to Tabar's Breast Cancer: The Art and Science of Early Detection with Mammography. Each volume will cover in depth a specific class of mammographic findings. Here, casting-type calcifications, and their significance in diagnosing cancer, are explored. Thick-section pathologic specimens are provided to help the reader understand why the mammograms look the way they do. A selection of full color pathologic images is provided in 3-D, allowing one to visualize the breast substructures in their spatial context.
  • Also available: Print – 2012
    Lipid rafts, caveolae, and GPI linked proteins / Valerie L. Reeves, Candice M. Thomas, and Eric J. Smart -- Caveolae and the regulation of endocytosis / Anna L. Kiss -- Caveolin : role in cell signaling / Cecile Boscher and Ivan Robert Nabi -- Regulation of ENOS in caveolae / Chieko Mineo and Philip W. Shaul -- Recent developments in the interactions between caveolin and pathogens / Fabiana S. Machado ... [et al.] -- Caveolin and breast cancer : a new clinical perspective / Isabelle Mercier and Michael P. Lisanti -- Caveolin and prostate cancer progression / Michael R. Freeman, Wei Yang, and Dolores Di Vizio -- Caveolins and caveolae, roles in insulin signalling, and diabetes / Peter Strolfors -- Atherosclerosis, caveolae, and caveolin / Stephanos Pavlides ... [et al.] -- Caveolins and heart diseases / Mathivadhani Panneerselvam, Hemal H. Patel, and David M. Roth -- Caveolins and lung function / Nikolaos A. Maniatis ... [et al.].
  • 1. Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression / T.C. Thompson, S.A. Tahir, L. Li, M. Watanabe, K. Naruishi, G. Yang, Ken-ichi Tabata, S. Kurosaka, K. Edamura, R. Tanimoto, P. Corn, D. Kadmon, C.J. Logothetis, P. Troncoso, C. Ren, A. Goltsov, and S. Park -- 2. Caveolin-1 in Colon Cancer: The Flexible Connection to Wnt Signaling / Andrew F.G. Quest, Vicente A. Torres, Diego A. Rodriguez, Jorge Gutierrez-Pajares, and Julio C. Tapia -- 3. Caveolin-1 and Pancreatic Ductal Adenocarcinoma / David W. Rittenhouse, Oeendree Mukherjee, Nathan G. Richards, Charles J. Yeo, Agnieszka K. Witkiewicz, and Jonathan R. Brody -- 4. Caveolin-1 in Brain Tumors / Rebecca Senetta and Paola Cassoni -- 5. The Role of Caveolin-1 in Skin Cancer -- / Alessandra Carè, Isabella Parolini, Federica Felicetti, and Massimo Sargiacomo -- 6. Caveolins in Tumor Angiogenesis / Grzegorz Sowa -- 7. Caveolin-1 and Breast Cancer / Gloria Bonuccelli and Michael P. Lisanti -- 8. Caveolin-1 and Cancer-Associated Stromal Fibroblasts / Isabelle Mercier and Michael P. Lisanti.
  • Histopathology and grading of breast cancer / Magda Esebua -- Multicentric/multifocal breast cancer : overview, biology, and therapy / Federico Buggi ... [et al.] -- Immune system in breast cancer initiation and progression : role of epithelial to mesenchymal transition / Keith L. Knutson and Erik C. Radisky -- Remodelling of the extracellular matrix : implication for cancer / Thomas R. Cox and Janine T. Erler -- Biology and treatment of basal-like breast cancer / Bingchen Han ... [et al.] -- Re-excision after lumpectomy for breast cancer / Suzanne B. Coopey -- Novel anti-angiogenic therapies using naturally occurring and synthetic drugs to combat progestin-dependent breast cancer / Salman M. Hyder, Benford Mafuvadze, and Cynthia Besch-Williford -- New insights on estrogen receptor actions in hormone-responsive breast cancer cells by interaction proteomics / Concetta Ambrosino ... [et al.] -- Reprogramming breast cancer cells with embryonic microenvironments : insights from nodal signaling / Gina Kirsammer and Mary J.C. Hendrix - Metastatic determinants : breast tumour cells in circulation / Nisha Kanwar and Susan J. Done -- Breast cancer epigenetics : biomarkers and therapeutic potential / Nancy H. Nabilsi ... [et al.] -- Impact of centrosome abnormalities on breast cancer development and progression with a focus on targeting centrosomes for breast cancer therapy / Heide Schatten -- New perspective on cyclin D1 : beyond cell cycle regulation / Chenguang Wang, Timothy G. Pestell, and Richard G. Pestell -- Gene signatures of inflammatory breast cancer : epithelial plasticity and a cancer stem cell phenotype / Fredika M. Robertson ... [et al.] -- Integrated human mammary epithelial cell culture system for studying carcinogenesis and aging / Martha R. Stampfer, Mark A. LaBarge, and James C. Garbe -- New breast cancer treatment considerations a brief review of the use of genetically modified (attenuated) bacteria as therapy for advanced and metastatic breast cancer / Robert A. Kazmierczak ... [et al.].
  • Part I: Starting the Cell Division Cycle -- 1 Escape from Cellular Quiescence -- 2 Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription -- 3 Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs -- Part II: Proliferation Under Duress -- 4 Mitotic Checkpoint and Chromosome Instability in Cancer -- 5 Mitotic Catastrophe -- 6 p53, ARF, and the Control of Autophagy -- Part III: Long-Term Proliferation -- 7 Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells -- 8 Maintenance of Telomeres in Cancer -- 9 The Senescence Secretome and Its Impact on Tumor Suppression and Cancer -- Part IV: Applications in Preventing and Treating Cancer -- 10 Cell Cycle Deregulation in Pre-neoplasia: Case Study of Barrett8217;s Oesophagus -- 11 Targeting Cyclin-Dependent Kinases for Cancer Therapy -- Index.
  • The ability of stem/progenitor cells to exit the cell cycle is essential for proper embryonic development, but the mechanisms governing cell cycle exit are still not fully understood. Correct regulation of G1 is critical for ensuring proper organismal development, tissue homeostasis, and tumor suppression. The Retinoblastoma (Rb) gene family is composed of three genes, Rb, p107, and p130, which are collectively thought to serve as essential regulators of the G1 phase of the cell cycle in most proliferating cell types. The Rb family has also been implicated in promoting the gene expression of several differentiation programs in different cell lineages. However, due to the overlapping and compensatory functions among the Rb family members, a complete understanding of how the Rb family controls the cell cycle and differentiation programs within a cell remains unclear. Furthermore, it has not yet been tested whether the Rb family members are the only mediators of these cellular processes, or if there are alternative mechanisms for cell cycle exit and differentiation in mammalian stem and progenitor cells. Here we tested the requirement for the Rb protein and its family members p107 and p130 in G1 arrest and differentiation in mammalian cells. We employed several strategies to conditionally remove the Rb family genes in entire embryos and in specific neural lineages, as well as multiple differentiation systems in vitro. We found that Rb family triple knock-out (TKO) mouse embryos survive until days 9-11 of gestation, with similar patterning and organogenesis as seen in wild type embryos. Strikingly, a number of TKO cells, including in the neural lineage, are able to exit the cell cycle in G1 and fully differentiate in vivo and in culture. This ability of TKO cells to arrest in G1 is associated with the repression of key cell cycle target genes for E2F and Myc transcription factors. Thus, G1 arrest can be achieved independently of Rb family members, illustrating the robustness of cell cycle regulatory networks during embryogenesis, and identifying a novel program that regulates cell cycle exit in G1 in mammalian cells.
  • Defects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients. Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies. In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death. Each chapter also highlights recent advances in the translation of basic research findings into clinical trials. Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens. The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes. Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways. Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities. In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies.
  • Cancer Morbidity and mortality result from invasive and metastatic spread. Advances in the field have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book presents an overview of these studies.
  • 1. GRB2 Signaling as a Molecular Target for Cancer / Alessio Giubellino -- 2. Human Arylamine N-acetyltransferase 1: From Drug Metabolism to Drug Target / Fernando Rodrigues-Lima, Julien Dairou, Florent Busi, and Jean-Marie Dupret -- 3. Targeting Argininosuccinate Synthetase in Cancer Therapy / Niramol Savaraj, Min You, Chunjing Wu, Macus Tien Kuo, Vy Dinh, Medhi Wangpaichitr, and Lynn Feun -- 4. Parathyroid Hormone-Related Peptide Signaling in Cancer / Franco Oreste Ranelletti and Giovanni Monego -- 5. Signalling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma / Francesco Piazza and Gianpietro Semenzato -- 6. Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract / Hiroshi Yasuda and Fumio Itoh -- 7. AIB1: A Transcriptional Coactivator Which Integrates Signaling Cross Talk in Cancer Cells / Macarena Ferrero and Jaime Font de Mora -- 8. Rational Design of DNA Anticancer Agent That Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy / Naijie Jing -- 9. Estrogen Receptor Signaling in Lung Cancer / P.A. Hershberger and J.M. Siegfried -- 10. Microparticle Dissemination of Biological Activities: Implications for Cancer Biology / Pauline P. Goh -- 11. Protein Kinase D Signaling in Cancer / Peter Storz -- 12. Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants / Peter Kovacic and Ratnasamy Somanathan -- 13. Targeting Signal Transducer and Activator of Transcription (STAT) for Anticancer Therapy / Fabio P.S. Santos, Inbal Hazan-Halevy, and Zeev Estrov.
  • This book provides a comprehensive account of the cellular pathology of glandular lesions and uncommon neoplasms of the cervix and places these in a contemporary clinical context. The book features comprehensive, detailed descriptions and a consistent approach to each tumor or tumor-like condition with clear color illustrations. Cytological/histological correlation is emphasised and diagnostic pitfalls are highlighted. Cellular Pathology of Glandular Lesions and Uncommon Neoplasms of the Cervix is aimed at both trainee and consultant pathologists.
  • The Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. Central Nervous System Intraoperative Cytopathology is a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.
  • Introduction to brain metastasis / Diane Palmieri -- Molecular biology of brain metastasis / Stephan Woditschka ... [et al.] -- Brain microenvironment / Mami Noda -- Vascular permeability within brain metastases / Chris E. Adkins ... [et al.] -- Imaging experimental brain metastases / Amanda M. Hamilton and Paula J. Foster -- Possibilities of targeted therapies for brain metastasis / Frank Winkler -- Surgery for brain metastasis / Douglas L. Stofko, Robert J. Weil, and Steven A. Toms -- Is there a role for systemic chemotherapy in the treatment of brain metastases / Marc C. Chamberlain -- Radiation therapy of CNS metastases / DeeDee Smart -- Leptomeningeal metastasis / Priscilla K. Brastianos, Charilaos H. Brastianos, and April F. Eichler -- Quality of life with CNS metastasis / Lauren A. Chandler and Kathleen L. Fuchs.
  • 1. Circuitry of Checkpoint Response -- Evasion of G1 Checkpoints in Cancer -- Distinct Pathways Involved in S-Phase Checkpoint Control -- Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response -- 2. Checkpoint Response and the Aetiology of Cancer -- Chromatin Modifications and Orchestration of Checkpoint Response in Cancer -- DNA Damage Response and the Balance Between Cell Survival and Cell Death -- Dysfunction of the RB Retinoblastoma Gene in Cancer -- G1 Phase Cyclins in Cancer Development and Progression -- The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls -- 3. Targeting Checkpoint Response in Cancer Therapy -- Regulation of p53 Activity and Associated Checkpoint Controls -- The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors -- Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy -- p27Kip1 as a Biomarker and Target for Treatment of Cancer -- Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors -- Chk1 and Chk2 as Checkpoint Targets -- Targeting Cdc25 Phosphatases in Cancer Therapy.
  • Historical Overview of Chemical Carcinogenesis -- Multistage Carcinogenesis -- Tobacco Smoke Carcinogens and Lung Cancer -- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products -- Heterocyclic Aromatic Amines: Potential Human Carcinogens -- Aflatoxin and Hepatocellular Carcinoma -- Metabolic Activation of Chemical Carcinogens -- Detoxication of Chemical Carcinogens and Chemoprevention -- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts: Carcinogenicity, Structure, and Function --Oxidation and Deamination of DNA by Endogenous Sources -- Lipid Peroxide-DNA Adducts -- Chemical Carcinogenesis and Epigenetics -- Nucleotide Excision Repair from Bacteria to Humans: Structure-Function Studies -- Base-Excision Repair: Role of DNA Polymerase ss in Late-Stage Base Excision Repair -- O⁶-Alkylguanine-DNA Alkyltransferase -- Bypass DNA Polymerases -- Mutagenesis: The Outcome of Faulty Replication of DNA -- p53 and Ras Mutations in Cancer and Experimental Carcinogenesis.
  • Introduction to cancer -- Antimetabolites -- DNA-interactive agents -- Antitubulin agents -- Cell signaling inhibitors -- Hormonal therapies -- Tumour targeting strategies -- Biologicals -- The future -- Personalized medicine (oncogenomics) -- Adjunct therapies.
  • Also available: Print – 2010
    Short introduction and history / Robert B. Raffa -- Patient's perspective / Robert B. Raffa and Kathy Martin -- Oncology nurse's perspective / Jamie S. Myers -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Neurocognitive effects of childhood cancer treatment / Jennifer Costa -- The economic burden / Albert I. Wertheimer -- Designing conceptual model-based research in chemotherapy-related changes in cognitive function / Lisa M. Hess -- Neuropsychologic testing for chemotherapy-related cognitive impairment / Jamie S. Myers -- Imaging as a means of studying chemotherapy-related cognitive impairment / Robert B. Raffa -- Chemotherapy associated central nervous system damage / Jørg Dietrich -- Is systemic anti-cancer therapy neurotoxic? Does chemo brain exist? And should we rename it? / Sophie Taillibert -- Evaluation of multiple neurotoxic outcomes in cancer chemotherapy / Bernard Weiss -- Chemotherapy-related visual system toxicity / Robert B. Raffa -- The possible role of cytokines in chemotherapy-induced cognitive deficits / Jamie S. Myers -- Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy / Swati Nagar -- Combination analysis / Ronald J. Tallarida -- Animal models / Ellen A. Walker -- Chemo brain (chemo fog) as a potential side effect of doxorubicin administration : role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction / Christopher D. Aluise ... [et al.] -- Effects of 5-FU / Peter M. Wigmore ... [et al.] -- Future directions / Robert B. Raffa and Ronald J. Tallarida.
  • Chemosensitivity v. 1-2, 2005.
    Springer Protocols
    v. 2, 2005 Springer Protocols
    v. 1. In vitro assays -- v. 2 In vitro models, imaging, and molecular regulators.
  • Scientific basis of cancer chemotherapy -- Norton-simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Continuous intravenous infusion chemotherapy -- Intraarterial chemotherapy -- Isolated regional therapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of chemotherapy -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of antineoplastic therapy -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Renal and electrolyte abnormalities due to chemotherapy -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- General issues in brain tumor chemotherapy -- Chemotherapy of head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestinal cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancers -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy of hodgkin's lymphoma -- Non-hodgkin's lymphoma -- Acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia -- Chemotherapy of the myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma and other plasma cell disorders.
  • 1. Introducing Cancer -- 2. Boveri's theory of cancer was ahead of its time -- 3. Genesis of "The enemy within"? -- 4. Gene mutation theory of cancer -- 5. The chromosomal imbalance theory of cancer -- 6. Theory of chromosomal imbalance solves mysteries and paradoxes -- 7. New perspectives for cancer prevention, diagnosis and therapy.
  • DNA repair and chromosomal translocations -- CINcere modelling: what have mouse models for chromosome instability taught us? -- Telomere dysfunction, chromosomal instability and cancer -- Genetic instability and disease progostication -- Causes of chromosomal instability -- Patterns of chromosomal aberrations in solid tumors -- Yeast as models of mitotic fidelty -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequence of aneuploidy in cancer: transcriptome and beyond.
  • This book comprises an in-depth view on the current knowledge of chronic clonal myeloid diseases. Special emphasis is laid on chronic myeloid leukaemia and a'classic' myeloproliferative disorders (essential thrombocythemia, polycythemia vera, and chronic idiopathic myelofibrosis) as well as myelodysplastic syndromes, oligoblastic leukemias, paroxysmal nocturnal hemoglobinuria and overlap diseases. Both young physicians in hematological training as well as practicing hematologists are addressed, with the aim of imparting a clear understanding of these disorders.
  • Introduction to Electroporation -- Electroporation and Cellular Physiology -- The Cell in the Electric Field -- Understanding Electric Fields for Clinical Use -- Generators and Applicators: Equipment for Electroporation -- Cell Electropermeabilization and Cellular Uptake of Small Molecules: The Electrochemotherapy Concept -- Vascular-Disrupting Action of Electrochemotherapy: Mode of Action and Therapeutic Implications -- Electrochemotherapy of Small Tumors; The Experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) Group -- Electrochemotherapy for Larger Malignant Tumors -- Cell Electroporation in Bone Tissue -- Drug and Gene Electrotransfer to the Brain -- Minimally Invasive Intraluminal Tumor Ablation -- Electrotransfer of Plasmid DNA -- Gene Electrotransfer to Tumor -- Gene Electrotransfer to Lung -- Gene Electrotransfer to Muscle Tissue: Moving into Clinical Use -- Gene Electrotransfer to Skin -- Electroporation-Mediated DNA Vaccination -- Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research -- Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck -- Clinical Research on Irreversible Electroporation of the Liver.
  • Skin tumors are very often encountered in clinical practice but can be difficult to diagnose since the skin's histological complexity gives rise to many types and subtypes. This superb atlas presents an unrivalled wealth of original high-quality clinical photographs of almost all benign and malignant skin tumors. The diverse subtypes and clinical forms, including different localizations, are depicted, and careful attention is paid to evolution and follow-up. While the main focus is on the clinical presentation as reflected in the photographs, diagnostic clues and management considerations are also summarized in a straightforward, readily understandable way. The atlas has been designed so that it will meet clinical needs and allow rapid identification of clues relevant to daily practice. Clinical Atlas of Skin Tumors will be valuable for all dermatologists in training, as well as for those who are already established in the profession or in allied specialties such as plastic surgery and oncology.
  • My Aunt Minnie -- Screening -- Diagnostic breast imaging -- Management.
  • Transcript / edited by E M Jones and E M Tansey -- Appendix 1. Timeline for UK Clinical Cancer Genetics Groups -- Appendix 2. Archival material from St Mark's Polyposis Registry -- Register cards / interpreted by Ms Kay Neale -- Letter from Dr C Dukes to Dr J C Burne -- Adaptation of poem, You Are Old Father William / by Dr C Dukes -- Obituary for Dr H J R Bussey / by Basil Morson -- Appendix 3. Pedigree of a Newfoundland family, 'Family C', with HNPCC -- Appendix 4. -- Cancer Genetics: a personal view / Professor David Harnden -- Glossary -- Biographical notes.
  • The main themes in this volume are the latest advances in the prevention of breast and prostate cancer and the role of infection in the development of liver and gastric cancer. Special emphasis is given to perspectives on the chemoprevention of breast cancer.
  • 1. Skin cancer of the ear: mastoid interpolation flap reconstruction tips -- 2. One technique fits all: the versatility of the full thickness graft on the lateral wall of the nose -- 3. Islands on the cheek: island flaps on the cheek and a modified oblique-sigmoid flaps -- 4. Rotation flaps of the scalp: study of the design, planning and biomechanics of single, double and triple pedicle flaps -- 5. Double-advancement 'H' flaps for very large defects of the forehead: design, planning and the use of sub-periosteal dissection to increase mobility -- 6. The modified rhomboid flap: an improvement on the traditional technique and its use in defects of the Ala Nasi --7. The keystone design perforator island flap: an easy option for the lower limb, but how does it actually work? -- 8. Amelanotic malignant melanoma of the toe presenting as an ulcer: management and biopsy guidelines -- 9. Revisiting the halo graft: why does it heal faster when compared to conventional split-skin grafts? -- 10. Balloon cell nevi and balloon cell melanomas: what are they? -- 11. Tropical treatment of skin cancers and the risks of 'figting fire and fire' -- 12. When a lipoma wasn't a lipoma: a discussion about granular cell tumors of skin -- 13. How small is small for a melanoma? -- 14. Multiple basal cell carcinomas and superficial radiotherapy (SRT) -- 15. Adenocystic carcinoma -- 16. Sebaceous carcinoma -- 17. Metastatic cutaneous adenocarcinoma -- 18. Zosteriform cutaneous metastasis -- Index.
  • Conceived as a guide for practitioners in their work in dermatology, this book is unique in its approach. From cutaneous signs to the richness of differential diagnosis, it guides practitioners through every step, from semiological analysis to diagnosis. The aim is to provide readers with the essentials of relevant dermatological reasoning. The first part of the book focuses on physical examination and on recognizing basic lesions, the practitioners building blocks. The diseases requiring understanding are then described in the form of a richly illustrated atlas, in which each diagram has been chosen as an exemplary educational tool. In the final part, differential diagnosis is proposed in the form of various tables summarizing the different cutaneous signs, providing readers with a complete toolkit to assist with diagnosis. This book will give trainee dermatologists, general physicians and internists the knowledge they need to identify basic lesions and a complete and detailed overview of the various diseases they are likely to encounter. At the same time, experienced dermatologists will find this book a valuable reference work for differential diagnosis.
  • 2012 ClinicalKey
    Preinvasive disease of the cervix / William T. Creasman -- Preinvasive disease of the vagina and vulva and related disorders / Joan L. Walker and Cara A. Mathews -- Invasive cervical cancer / Krishnansu S. Tewari and Bradley J. Monk -- Endometrial hyperplasia, estrogen therapy, and the prevention of endometrial cancer / Lisa M. Landrum, Rosemary E. Zuna, and Joan L. Walker -- Adenocarcinoma of the uterine corpus / William T. Creasman and David Scott Miller -- Sarcoma of the uterus / D. Scott McMeekin -- Gestational trophoblastic disease / Emily M. Ko and John T. Soper -- Invasive cancer of the vulva / Jeanne M. Schilder and Frederick B. Stehman -- Invasive cancer of the vagina / Brian M. Slomovitz and Robert L. Coleman -- The adnexal mass / D. Scott McMeekin, Robert Mannel, and Philip J. Disaia -- Epithelial ovarian cancer / Eric L. Eisenhauer, Ritu Salani, and Larry J. Copeland -- Germ cell, stromal, and other ovarian tumors / Michael A. Bidus, John C. Elkas, and G. Scott Rose -- Fallopian tube cancer / Michael A. Bidus, G. Larry Maxwell, and G. Scott Rose -- Breast diseases / Mary L. Gemignani -- Cancer in pregnancy / Krishnansu S. Tewari -- Complications of disease and therapy / Daniel L. Clarke-Pearson -- Basic principles of chemotherapy / Christina S. Chu and Stephen C. Rubin -- Targeted therapy and molecular genetics / Shannon N. Westin, Anil K. Sood, and Robert L. Coleman -- Genes and cancer : genetic counseling and clinical management / David G. Mutch and Philip J. DiSaia -- Palliative care and quality of life / Dana M Chase ... [et al.] -- Role of minimally invasive surgery in gynecologic malignancies / Jeffrey M. Fowler, David E. Cohn, and Robert S. Mannel -- Epidemiology of commonly used statistical terms and analysis of clinical studies / Wendy R. Brewster -- Basic principles in gynecologic radiotherapy / Catheryn M. Yashar.
  • Principles of embolization -- Principles of percutaneous ablative therapies -- Principles of isolated regional perfusion of the extremity or liver -- Principles of radiotherapy -- Tumor response for image-guided interventions: ASSESSMENT AND VALIDATION -- Trends in basic science research in interventional radiology: NANOTECHNOLOGY, STEM CELL, RNAi, AND RADIOGENOMICS -- Surgical management of hepatocellular carcinoma -- Interventional management of hepatocellular carcinoma -- Systemic therapy in advanced hepatocellular carcinoma -- Cholangiocarcinoma: Diagnosis, management, and prognosis -- Percutaneous management of cholangiocarcinoma -- The multidisciplinary management of liver metastases in colorectal cancer -- Surgical management of hepatic metastases -- Interventional radiology in the management of colorectal cancer liver metastases -- Gastroenteropancreatic neuroendocrine tumors -- Interventional oncology management of noncolorectal and nonneuroendocrine hepatic metastatic disease -- Percutaneous management of renal tumors -- Interventional strategies in the treatment of gynecologic cancers -- Image-based interventional therapies for benign uterine neoplasms -- Prostate cancer intervention -- Imaging of head and neck cancer -- Transcatheter chemotherapy for malignancies in the brain, head, and neck -- Head: Intracranial - gliomas, and meningiomas and extracranial - orbits, internal auditory canals, and skull base -- Primary lung carcinoma -- Metastatic disease -- Percutaneous musculoskeletal biopsy -- Musculoskeletal interventions for benign bone lesions -- Ablation of musculoskeletal metastatic lesions including cementoplasty -- Vertebroplasty and kyphoplasty in malignant vertebral fracture -- Intraarterial procedures for the musculoskeletal system.
  • Clinical management of thyroid cancer / Kennichi Kakudo & Zhiyan Liu -- Diagnosis of thyroid cancer / Joseph M. Shulan & Jennifer A. Sipos -- Thyroid cancer : classification and cytological diagnosis / Zvonimir L. Milas, Jennifer Brainard & Mira Milas -- Molecular genetics of thyroid cancer / Angela Greco, Claudia Miranda, Maria Grazia Borrello & Marco A. Pierotti -- Etiopathogenic factors of thyroid cancer / Ana Lourenço Almeida, Paula Boaventura & Paula Soares -- Differentiated thyroid carcinoma: prognostic stratification and molecular classification / Michele N. Minuto, Emanuela Varaldo & Giuseppina Talamo -- Radiotherapy : radioiodine and external beam irradiation treatment of differentiated thyroid carcinomas / Miguel Melo, Gracinda Costa, Francisco Carrilho, Manuela Carvalheiro & Paula Soares -- Borderline lesions in thyroid tumor classification and well-differentiated tumor of uncertain malignant potential Zhiyan Liu, Bo Han, Yanhua Bai, Yaqiong Li, Osamu Nunobiki & Kennichi Kakudo -- Differentiated thyroid cancer in children / Andrew J. Bauer, Catherine A. Dinauer, Steven G. Waguespack & Gary L. Francis -- Index.
  • 1. Principles of Clinical Epidemiology / Annette C. Moll, Michiel R. de Boer, Lex M. Bouter, and Nakul Singh -- 2. Etiology of Cancer / Brian T. Hill -- 3. Cancer Pathology / Katarina Bartuma, Charlotta All-Ericsson, and Stefan Seregard -- 4. Cancer Angiogenesis / Werner Wackernagel, Bela Anand-Apte, and Arun D. Singh -- 5. Immunology of Ocular Tumors / Martine J. Jager and Inge H.G. Bronkhorst -- 6. Cancer Genetics / J.William Harbour and Daniel L. Chao -- 7. Cancer Staging / Paul T. Finger -- 8. Principles of Cryotherapy / Dan S. Gombos -- 9. Principles of Laser Therapy / Stefan Sacu and Ursula Schmidt-Erfurth -- 10. Principles of Radiation Therapy / Abigail L. Stockham, Ehsan H. Balagamwala, Roger Macklis, Allan Wilkinson, and Arun D. Singh -- 11. Ocular Complications of Radiotherapy / Mitchell Kamrava, James Lamb, and Tara A. McCannel -- 12. Principles and Complications of Chemotherapy / Michael G. Levien, Nicola G. Ghazi, and Arun D. Singh -- 13. Targeted Therapy and Their Ocular Complications / Denis Jusufbegovic, Pierre L. Triozzi, and Arun D. Singh -- 14. Counseling Patients with Cancer / Laura Hope-Stone and Bertil Damato -- 15. Cataract Associated with Intraocular Tumors / Carlos A. Medina, Mary E. Aronow, and Arun D. Singh -- 16. Tumor-Associated Glaucoma / Reena S. Vaswani, Kathryn Bollinger, Annapurna Singh, and Arun D. Singh -- 17. Graft-Versus-Host Disease / Edgar M. Espana, Sejal Shah, and Arun D. Singh -- 18. Uveal Tumors: Diagnostic Techniques: Angiography / Kaan Gunduz, Jessica A. Adefusika, Thomas P. Link, and Jose S. Pulido -- 19. Diagnostic Techniques: Optical Coherence Tomography / Rubens Belfort, Andre Romano, Eduardo Rodrigues, and Arun D. Singh -- 20. Diagnostic Techniques: Autofluorescence / Edoardo Midena, Elisabetta Pilotto, and Raffaele Parrozzani -- 21. Diagnostic Techniques: Ophthalmic Ultrasonography / Brandy Hayden Lorek, Mary E. Aronow, and Arun D. Singh.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors are carefully explained, and treatment options are considered in detail.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations Locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.
  • Evaluation and Diagnosis -- Leukocoria: Differential Diagnosis -- Staging and Grouping -- Epidemiologic Aspects -- International Perspective -- Tumorigenesis -- Retinocytoma or Retinoma -- Genetic Counseling and Testing -- Treatment Options -- Focal Therapy -- Intravenous Chemotherapy -- Intra-Arterial Chemotherapy -- Intravitreal Chemotherapy -- Teletherapy -- Enucleaton -- Histopathologic Features and Risk Factors -- Orbital Retinoblastoma -- Metastatic Disease -- Non Ocular Tumors -- Trilateral Retinoblastoma -- Children's Oncology Group (COG) Trials for Retinoblastoma.
  • "This volume, devoted solely to uveal tumors, explains the various diagnostic and biopsy techniques that may be used and describes the therapeutic options of potential value for different types of tumor."--Publisher's website.
  • Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team. Content.
  • This book, unique in focusing specifically on cardiac masses, is the result of cooperation among a number of teams of radiologists working under the aegis of the French Society of Cardiovascular Imaging (SFICV). Its goal is to 1) review the different CMR sequences and CT acquisition protocols used to explore cardiac masses, 2) to demonstrate the several CMR and MDCT features of cardiac masses. It has been designed as a teaching tool and offers a fully illustrated compendium of clinical cases, tables summarizing data, and decision-making trees essential in everyday practice. It is presented as a practical handbook and can be either read cover to cover or consulted whenever needed during a cardiac imaging assignment. The book is intended for all students and experienced practitioners, whether radiologists or not, who are interested in cardiac or thoracic pathology.
  • Covers three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors.
  • There have been many changes in the field of coagulation during the past decade. New concepts of epidemiology of risk factors for thrombosis now help clinicians predict who is more likely to form clots after surgery, or after being placed on oral contraceptives. New anticoagulants have the potential to redefine how patients with atrial fibrillation and venous thrombosis are managed. There are new forms of recombinant clotting factors which have changed our approach to hypofibrinogenemia and von Willebrand's disease. Newer antiplatelet agents are available and their use in patients receiving cardiac stents has mushroomed. The management of thrombosis in the setting of pregnancy has changed over the past decade, as well as the way clinicians approach women with multiple miscarriages. An entire new class of compounds, the thrombopoietins, are available to treat individuals with immune thrombocytopenic purpura (ITP). The Coagulation Consult covers major topics of interest to hematologists who are asked to consult on individuals with coagulation related diseases, and encompasses the field's most recent developments. This "case-directed" book describes state-of-the-art approaches to patients with bleeding and clotting disorders, as well as laboratory tests for coagulation. Chapters include different vignettes, focus on typical clinical consult questions, and lay out specific types of treatment. Practicing clinicians being confronted with a coagulation consult, students, residents, fellows and attending physicians will find this unique text an invaluable resource for some of the newer areas of coagulation science, therapy and pharmacology.
  • Also available: Print – 2009
  • Also available: Print – 2006
    Metallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
  • This book explains clearly the nature of colon polyps and their relationship with colorectal cancer, which is among the three most common cancers in both men and women. Up-to-date information is provided on anatomy, pathology, types of polyp and their treatment, and the performance of colonoscopy. Particular attention is devoted to the risk factors for development of colorectal cancer, with detailed guidance on its prevention and early diagnosis and treatment. While the book is primarily intended for medical specialists and students, a deliberate and consistent effort has been made to use plain language that will enable other interested persons, including patients, to understand all aspects of the subject.
  • Physical and technical principles of color Doppler sonography / R. Kubale and G. Hetzel -- Safety aspects of Doppler and color Doppler sonography / H.-D. Rott -- Uterine blood flow in fertile and infertile women / S. Kupesic and A. Kurjak -- Uterine causes of infertility / S. Kupesic and A. Kurjak -- Changes in uterine and ovarian perfusion with the onset of menopause / A. Kurjak and S. Kupesic -- Color Doppler sonography for the optimization of assisted reproduction / D. Grab and K. Sterzik -- Pulsed Doppler and color duplex sonography in the assessment of tubal patency / B. Hüneke ... [et al.] -- Abnormalities of corpus iuteum function / S. Kupesic, A. Kurjak, T. Zodan -- Interventional ultrasound in reproductive medicine / S. Kupesic, A. Kurjak, and A.K. Ertan -- Doppler ultrasound examinations from folliculogenesis to early pregnancy / S. Kupesic, A. Kurjak, and W. Schmidt -- Evaluation of early placentation and the embryonic circulation with Doppler ultrasound / A. Kurjak and S. Kupesic -- Color Doppler sonography in ectopic pregnancy / H.J. Voigt. Physiology of Doppler flow in maternal vessels during pregnancy / T. Golaszewski, J. Deutinger, and G. Bernaschek -- Color Doppler sonography of the uterine arteries in early pregnancy to screen for preeclampsia and uteroplacental insufficiency / A. Funk -- Normal fetomaternal Doppler indices in the second and third trimesters of pregnancy / A.K. Ertan ... [et al.] -- Venous Doppler sonography / F. Bahlmann -- Color Doppler sonography in the diagnosis of Nuchal cord / A.K. Ertan, H.J. Hendrik, W. Schmidt -- Chronic placental insufficiency / H.J. Hendrik, A.K. Ertan, and W. Schmidt -- Severely abnormal Doppler findings and perinatal abnormalities / A.K. Ertan, H.J. Hendrik, W. Schmidt -- Fetal Doppler findings in late pregnancy / K. Vetter -- Intrapartum Fetal Heart Rate changes and Doppler sonography / E. Weiss -- Color Doppler ultrasound in fetal echocardiography / A. Lindinger -- Use of color Doppler in echocardiography / U. Gembruch -- Structure of the human placenta and pathomorphological changes in placental insufficiency / K.R. Reitnauer. Morphological and morphometric studies of the placenta with Doppler abnormalities of the fetal umbilical arteries / T. Hitschold -- Sonographic and Doppler sonographic examination of uterine anomalies / S. Kupesic and A. Kurjak -- Doppler examination of the normal endometrium and benign endometrial changes / S. Kupesic, A. Kurjak -- Transvaginal color Doppler and pulsed Doppler diagnosis of benign changes in the uterine myometrium / A. Kurjak, S. Kupesic -- Use of color Doppler in the evaluation of suspicious endometrial findings / M. Holländer ... [et al.] -- Malignant uterine tumors / A. Kurjak and S. Kupesic -- Blood flow changes in cervical carcinoma treated by primary chemotherapy / C. Villena-Heinsen ... [et al.] -- Color Doppler imaging of benign adnexal masses-a spectrum of findings / A. Kurjak, S. Kupesic, and A.K. Ertan -- Malignant adnexal tumors / A. Kurjak, S. Kupesic, and A.K. Ertan -- Three-dimensional power Doppler sonography in evaluating the angiogenesis of ovarian tumors / A. Kurjak, S. Kupesic, and B. Breyer -- Ovarian cancer screening / A. Kurjak ... [et al.]. General aspects of the ultrasound investigation of blood flow in breast tumors / C. Villena-Heinsen, M. Holländer, and W. Schmidt -- Color Doppler sonography in the diagnosis of breast cancer / H. Madjar -- Usefulness of the minimum resistance index in the benign-malignant discrimination of breast tumors / C. Villena-Heinsen ... [et al.] -- Effect of menopausal status and hormone replacement on therapy resistance indices and blood flow velocities in breast tumors / C. Villena-Heinsen, I. Tossounidis, and W. Schmidt -- Benign-malignant tumor discrimination and prognostic evaluation of breast tumors with color Doppler sonography / C. Villena-Heinsen ... [et al.].
  • Colorectal cancer 2010
    Epidemiology and risk factors of colorectal cancer / Kathryn M. Chu -- Presentation and initial evaluation of colorectal cancer / Susan Tsai and Susan L. Gearhart -- Hereditary colorectal cancer and polyp syndromes / Francis M. Giardiello -- Genetic screening / Cheryl J. Pendergrass -- Behavior and dietary modification in the prevention of colon cancer / Stephanie Downing, Emmanouil P. Pappou, and Nita Ahuja -- Chemoprevention of colorectal cancer / Melissa A. Munsell and Francis M. Giardiello -- Fecal occult blood test / Michel A. Kafrouni and John H. Kwon -- Colonoscopy and flexible sigmoidoscopy in colorectal cancer screening and -- Surveillance / Michelle N. Zikusoka and John H. Kwon -- Stool and blood sampling for early detection of colorectal cancer / Jason K. Sicklick and Nita Ahuja -- Radiologic techniques : virtual colonoscopy / Karen M. Horton -- Preoperative evaluation / Jerry Stonemetz, Nicole A. Phillips, and Susan L. Gearhart -- Limited resection : indications, techniques, and outcomes of transanal excision and -- Transanal endoscopic microsurgery / Elizabeth C. Wick -- Minimally invasive techniques : indications, techniques, and outcomes / Susan L. Gearhart -- Endoscopic techniques in colorectal neoplasia / Eun i. Shin and Samuel A. Giday -- Open surgical techniques in colorectal cancer / Vanita Ahuja -- Systemic therapy for colon cancer / Khaled El-Shami, Sujatha Nallapareddy, and Wells Messersmith -- Radiation therapy for colorectal adenocarcinoma : external beam and intraoperative -- Radiation therapy / Joseph M. Herman and Timothy M. Pawlik -- Surveillance and follow-up / Matthew T. Hueman and Nita Ahuja -- Clinical trials : why participate? / Jamila Mwidau and David Chang -- Vaccines and immunotherapy / Ajay Jain and Richard Schulick -- Genetic profiling in colorectal cancer / Debashish Bose and Nita Ahuja -- Coping with colorectal cancer / Eden R. Stotsky.
  • Colorectal cancer 2009
  • Molecular biology of colon cancer / William M. Grady -- Chemoprevention of colorectal cancer / Yu-Ning Wong ...[et al.] -- Colorectal cancer screening and surveillance / Arnold J. Markowitz -- Cytotoxic chemotherapy for metastatic colorectal cancer / M. Wasif Saif, Richard Kim, and Edward Chu -- Integration of antiangiogenic strategies in colorectal cancer treatment / John M. Strother and Charles D. Blanke -- The role of EGFR inhibition in colorectal cancer / Nabeel Shalan and Paulo M. Hoff -- Second-line strategies in the treatment of patients with metastatic colorectal cancer / Anthony B. El-Khoueiry and Heinz-Josef Lenz -- Adjuvant chemotherapy for colon cancer / Bert H. O'Neil ... [et al.] -- Management of locally advanced rectal cancer / Yu Jo Chua and David Cunningham -- Rationale for adjuvant and neoadjuvant chemotherapy in the resection of liver metastases / Axel Grothey and Steven A. Alberts -- Percutaneous radiofrequency ablation in the management of patients with colorectal cancer / Karen Brown -- Colorectal cancer imaging / Sean D. Curran and Laurence H. Schwartz -- Nursing issues in colorectal cancer chemotherapy / Ellen Hollywood and Deborah Semple -- Pain management in the colorectal cancer patient / Vivek Tim Malhotra -- Novel agents and new paradigms for colorectal cancer / Chris Takimoto and Russell Kruzelock.
  • As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. Disease management in these patients poses a unique challenge as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. Appropriate management of elderly patients demands a greater understanding of not only the physiological changes but also issues related to the delivery of holistic care. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.
  • Colorectal cancer pathways / Petr Protiva -- Risk factors and screening for colorectal cancer / Joseph C. Anderson -- Hereditary adenomatous colorectal cancer syndromes / Maqsood Khan and Carol A Burke -- Screening and surveillance guidelines / Robert J. Chehade and Douglas J. Robertson -- Barriers to colorectal cancer screening : patient, physician, and system factors / Catherine R. Messina -- Screening for colorectal cancer using colonoscopy / Douglas K. Rex -- New colonoscopic technologies for colorectal cancer screening / Douglas K. Rex -- Screening for CRC using CT colonography / Brooks D. Cash -- Noninvasive screening tests / Nabil Fayad and Thomas F. Imperiale -- Removal of difficult colon polyps / Jerome Waye -- Screening for colorectal cancer in the elderly / Charles J. Kahi -- Chemoprevention / Jeffrey Singerman and Petr Protiva.
  • Targeting of the EGFR as a modulator of cancer chemotherapy / Jose Baselga -- Cyclin dependent kinase inhibitors in combination chemotherapy / Manish A. Shah and Gary K. Schwartz -- Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia / Steven Grant -- Carboxyamidotriazole, an inhibitor of nonvoltage operated calcium entry : single agent and combination therapy for ovarian carcinoma / Chad M. Michener and Elise C. Kohn -- Targeted alpha particle therapy : a rational approach to drug development in hematologic diseases and solid tumors / John M. Burke, David A. Scheinberg, and Joseph G. Jurcic -- Pharmacologic modulation of fluoropyrimidines : building upon the lessons of the past / Owen A. O'Connor -- Development of inhibitors of HER2 with taxanes : new directions in breast cancer therapy / Shanu Modi, Monica N. Fornier, and Andrew D. Seidman -- Targeting nf-b to increase the activity of cisplatin in solid tumors / Don S. Dizon ... [et al.] -- Combinations of chemotherapy and G3139, an antisense BCL-2 oligonucleotide / Luba Benimetskaya, Sridhar Nami, and C. A. Stein -- Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy / Beverly A. Teicher.
  • Also available: Print – 2007
  • Diagnosis and staging -- Primary treatment -- Communication within the context of multidisciplinary care -- Explaining follow-up -- Progression and terminal -- Explaining research -- Complementary and alternative medicines and integrative oncology.
  • Also available: Print – 2006
  • Also available: Print – 2015
    Despite tremendous recent advances in the treatment of most malignancies, there remain several critical questions for each cancer. This particularly true for the surgical management of solid-organ malignancies. Comparative effectiveness is a relatively new term which encompasses the age-old concepts of how best to treat cancer patients. Comparative effectiveness is defined as the direct comparison of healthcare interventions to determine which work best for which patients when considering the benefits and risks. The Institute of Medicine has defined comparative effectiveness research (CER) as the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. CER is certainly best done with well-conducted randomized controlled trials. Unfortunately, clinical trials are not always feasible owing to the impracticality of conducting the trial, the considerable cost, and the time required to complete the trial. These challenges are even more pronounced with respect to surgical treatment. Thus alternative approaches may need to be considered in order to address pressing questions in the care of the oncology patient. These approaches may include well-conducted retrospective cohort studies from cancer registries and other data sources, decision and cost-effectiveness analyses, and other novel methodologies. This book lays out the current critical questions for each major malignancy and proposes approaches to gain answers to these pressing questions.
  • Complementary & Alternative Medicine for Prostate and Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This is a critical distinction between this book and any other Complementary & Alternative Medicine (CAM) books published to date. Each section of the book provides an easy to reference guide into the topic of interest for the individual that works in urology. The various sub-specialty groups in urology are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether it is fertility, bladder cancer, or prostate disease. Rather than having to sort through the now thousands of articles published yearly on CAM in medicine, this volume focuses first on the specialty and secondarily how it compares to the overall CAM literature. Each chapter includes a summary page that will allow the physician a rapid review of the subject with a patient, colleague or student.
  • v. 2 Future Med
    Volume 1. Breast cancer -- High-risk breast lesions / Vance Sohn -- Surgical management of ductal carcinoma in situ / Rosalinda Alvarado -- Regional lymph node metastases in breast cancer / Sarah DeSnyder -- Neoadjuvant/adjuvant therapy for breast cancer / Sarah DeSnyder -- Nonductal malignancies / Sarah DeSnyder -- Management of high-risk breast cancer syndromes / Rosalinda Alvarado -- Reconstruction following breast surgery / Steve Lee & Daniel E. Abbott -- Endocrine malignancies -- Well-differentiated thyroid cancer / Steve Lee & Daniel E. Abbott -- Multiple endocrine neoplasia / Paxton Dickson -- Adrenal pathology and approaches to resection / Daniel E. Abbott -- Melanoma -- Margins in melanoma / Genevieve Boland -- Sentinel lymph node biopsy in melanoma / Genevieve Boland -- In-transit disease and regional therapy / Vance Sohn -- Soft-tissue sarcoma -- Retroperitoneal sarcoma / Alex Haynes -- Adjuvant/neoadjuvant therapy for sarcoma / Christina L. Roland -- Esophageal cancer -- EMR, RFA and argon plasma coagulation for treatment of Barrett's esophagus and early adenocarcinoma / Amanda Cooper -- Distal esophageal tumors / Maria C. Russell -- Squamous cell versus adenocarcinoma of the esophagus / Christina L. Roland -- Index. Volume 2. Gastric cancer -- Gastric adenocarcinoma / Maria Citarella Russell -- Small bowel cancer -- Small bowel neoplasms / Paxton Dickson -- Colorectal cancer -- Management of rectal cancer / Genevieve Boland -- Hereditary colorectal cancer syndromes / Christina Bailey -- Reconstruction after low rectal resections and pelvic exenteration / Amanda Cooper -- Hepatobiliary cancer -- Cholangiocarcinoma / Daniel E. Abbott -- Hepatic metastases / Genevieve Boland -- Resection and ablation techniques for hepatic lesions / Steve Lee & Daniel E. Abbott -- Resection versus transplantation for hepatocellular carcinoma / Christina L. Roland -- Pancreatic cancer -- Pancreatic cystic neoplasms / Robert E. Roses -- Pancreatic adenocarcinoma / Daniel E. Abbott -- Neuroendocrine tumors of the pancreas / Alex Haynes -- Conditions affecting the pancreaticobiliary system / Vance Sohn -- Peritoneal malignancy -- Peritoneal mesothelioma / Vance Sohn -- Index.
  • Identification of Relevant Genes from Microarray Experiments based on Partial Least Squares Weights: Application to Cancer Genomics -- Geometric Biclustering and Its Applications to Cancer Tissue Classification Based on DNA Microarray Gene Expression Data -- Statistical Analysis on Microarray Data: Selection of Gene Prognosis Signatures -- Agent-Based Modeling of Ductal Carcinoma In Situ: Application to Patient-Specific Breast Cancer Modeling -- Multicluster Class-Based Classification for the Diagnosis of Suspicious Areas in Digital Mammograms -- Analysis of Cancer Data Using Evolutionary Computation -- Analysis of Population-Based Genetic Association Studies Applied to Cancer Susceptibility and Prognosis -- Selected Applications of Graph-Based Tracking Methods for Cancer Research -- Recent Advances in Cell Classification for Cancer Research and Drug Discovery -- Computational Tools and Resources for Systems Biology Approaches in Cancer -- Laser Speckle Imaging for Blood Flow Analysis -- The Challenges in Blood Proteomic Biomarker Discovery.
  • Content-based image retrieval (CBIR) is the process of retrieval of images from a database that are similar to a query image, using measures derived from the images themselves, rather than relying on accompanying text or annotation. To achieve CBIR, the contents of the images need to be characterized by quantitative features; the features of the query image are compared with the features of each image in the database and images having high similarity with respect to the query image are retrieved and displayed. CBIR of medical images is a useful tool and could provide radiologists with assistance in the form of a display of relevant past cases. One of the challenging aspects of CBIR is to extract features from the images to represent their visual, diagnostic, or application-specific information content. In this book, methods are presented for preprocessing, segmentation, landmarking, feature extraction, and indexing of mammograms for CBIR. The preprocessing steps include anisotropic diffusion and the Wiener filter to remove noise and perform image enhancement. Techniques are described for segmentation of the breast and fibroglandular disk, including maximum entropy, a moment-preserving method, and Otsu's method. Image processing techniques are described for automatic detection of the nipple and the edge of the pectoral muscle via analysis in the Radon domain. By using the nipple and the pectoral muscle as landmarks, mammograms are divided into their internal, external, upper, and lower parts for further analysis. Methods are presented for feature extraction using texture analysis, shape analysis, granulometric analysis, moments, and statistical measures.
  • Aging is a degenerative process accompanied by tissue deterioration, decline in function and increased susceptibility to disease. It is now understood to be a genetically and environmentally regulated process, rather than simply the result of wear and tear. We developed a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tissues and organisms, and identified the transcription factor NF-[kappa]B as a candidate regulator of aging. Using multiple independent models, we show a role for NF-[kappa]B in regulating transcriptional programs of aging. First, we found that aged mice subjected to NF-[kappa]B blockade for two weeks exhibit reversion of the tissue characteristics and global gene expression programs to those of young mice. Next, we detected deregulated transcriptional activity of NF-[kappa]B in Sirt6-deficient mice, which exhibit premature aging-like symptoms. We show that Sirt6 interacts with the NF-[kappa]B RelA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-[kappa]B target gene promoters. Computational genomics analyses revealed increased activity of NF-[kappa]B-driven gene expression programs in multiple Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice, suggesting that hyperactive NF-[kappa]B-dependent transcription in the absence of Sirt6 promotes premature aging-like syndromes. Finally, we performed a genome-scale survey of RelA and Sirt6 location on chromatin in mouse embryonic fibroblasts (MEFs) via chromatin immunoprecipiation (ChIP)-on-chip to understand to what extent Sirt6 and RelA act coordinately to regulate gene expression. These results indicate that RelA and Sirt6 co-occupy the promoters of a large population of genes at sites less than 500kb apart and/or require RelA to enable binding of Sirt6. Expression analysis of these shared targets reveals direct regulation of 301 promoters, including genes such as Shc1 (encoding p66), Cdkn2a (encoding p16), Wnt2 and Jmjd3, which have been separately implicated in the aging process. We propose that hyperactive NF-[kappa]B signaling contributes to premature and normal aging.
  • Gynecological cancers are some of the most commonly occurring malignancies in women. Despite their high incidence, treatment and management of these cancers remain controversial, with conflicting evidence about many aspects of the disease. Controversies in the Management of Gynecological Cancers offers a unique assessment of the opposing sides of the controversial issues associated with gynecological cancers, and aims to provide professionals in the field with a keener sense of the underlying evidence-base and a starting point from which to follow the ongoing debate. A section on the direction of future research to resolve these issues completes the discussion in each chapter. This book will appeal to specialists, trainees and healthcare workers in gynecological oncology, gynecologists, medical oncologists and radiation oncologists, and is an excellent starting point for anyone who wishes to gain a better understanding of the complex nature of the management of gynecological malignancy.
  • Prognostic factors in histopathology of lung cancer / A. Fisseler-Eckhoff -- FDG-PET/CT in lung cancer : an update / R.-P. Baum, C. Świętaszczyk, V. Prasad -- Whole-body magnetic resonance imaging for staging of lung cancer / R. Puls ... [et al.] -- Bronchoscopy/endobronchial ultrasound / F.J.F. Herth -- New developments in videomediastinoscopy : video-assisted mediastinoscopic lymphadenectomy and mediastinoscopic ultrasound / B. Witte -- Resection in stage I/II non-small cell lung cancer / F.M. Smolle-Juettner ... [et al.] -- Role of mediastinal lymph node dissection in non-small cell lung cancer / S. Bölükbas, M.H. Eberlein, J. Schirren -- Radiation therapy for early stage (I/II) non-small cell lung cancer / B. Jeremic ... [et al.] -- Stereotactic body radiation therapy for early non-small cell lung cancer / F. Zimmermann ... [et al.] -- Extended surgical resection in stage III non-small cell lung cancer / S. Hillinger, W. Weder -- Stage III : definitive chemoradiotherapy / R. Fietkau, S. Semrau -- Adjuvant therapy in early-stage non-small cell lung cancer / M. Serke -- Postoperative irradiation in non-small cell lung cancer / S. Höcht ... [et al.] -- Altered fractionation schemes in radiotherapy / M. Stuschke, C. Pöttgen -- Chemotherapy of advanced non-small cell lung cancer / R. Pirker, W. Minar -- Radiotherapy / I.A. Adamietz -- Treatment of limited disease small cell lung cancer / D. de Ruysscher -- Radiochemotherapy in extensive disease small cell lung cancer ED-SCLC / B. Jeremic ... [et al.] -- Radiotherapy for extensive stage small cell lung cancer / B.J. Slotman -- Controversies in the treatment of advanced stages of small cell lung cancer / A. Schmittel -- Complementary and alternative medicine in lung cancer patients : a neglected phenomenon? / O. Micke.
  • Prostate cancer and active surveillance / Abrahamsson, P.A. -- Radical Prostatectomy in the 21th Century: the gold standard for localized and locally advanced prostate cancer / Schostak, M.; Miller, K.; Schrader, M. -- Radiotherapy as primary treatment modality / Sia, M.; Rosewall, T.; Warde, P. -- Combined radiotherapy and hormonal therapy in the treatment of prostate cancer / Boehmer, D. -- Postoperative adjuvant radiotherapy: standard of care? / Bottke, D.; Wiegel, T. -- Adjuvant hormonal treatment: the bicalutamide early prostate cancer program / Wirth, M.P.; Hakenberg, O.W.; Froehner, M. -- Hormone therapy for prostate cancer: immediate initiation / Schostak, M.; Miller, K.; Schrader, M. -- Lymphadenectomy in prostate cancer: radioguided lymph node mapping: an adequate staging method / Winter, A.; Wawroschek, F. -- Radiotherapy in lymph-node positive prostate cancer patients: potentially curable?: single institutional experience regarding outcome and side effects / Goldner, G.; Pötter, R. -- Radiotherapy in biochemical recurrences after surgery for prostate cancer / Hocht, S. ... [et al.] -- Recurrence following radiotherapy / Desgrandchamps, F. -- Secondary hormonal manipulation / Merseburger, A.S. ... [et al.] -- Chemotherapy in hormone-refractory prostate cancer / Wolff, J.M. -- A randomized phase II trial comparing weekly taxotere + prednisone (P) versus prednisone alone in androgen-independent prostate cancer / Fossa, S.D. -- Hormone-refractory and metastatic prostate cancer: palliative radiotherapy / Moser, L.; Schubert, T.; Hinkelbein, W.
  • Cutaneous lymphomas - radiotherapeutic strategies / Wilson, L.D., Jones, G.W., Smith, B.D. -- The clinical impact of T cell receptor rearrangement analysis in cutaneous T cell lymphoma / Assaf, C. -- Classification of primary cutaneous lymphomas / Assaf, C. ... [et al.] -- Basal cell and squamous cell carcinoma - radiotherapeutic approaches / Panizzon, R.G. -- Kaposi's sarcoma - radiotherapeutic aspects / Niewald, M.; Räbe, C. -- Pathogenesis and clinical manifestation of Kaposi's sarcoma / Geilen, C.C., Husak, R., Steinhoff, M. -- Merkel cell carcinoma - clinical presentation and treatment / Moll, I. -- Merkel cell carcinoma - uncommon and aggressive cutaneous tumour / Greiner, R.H. ... [et al.] -- Potential of radiation therapy in the multimodal management of Merkel cell carcinoma / Becker, G., Bottke, D. -- Skin and other reactions to radiotherapy - clinical presentation and radiobiology of skin reactions / Dörr, W. -- Management of skin and related reactions to radiotherapy / Seegenschmiedt, H. -- Malignant melanoma - markers for progression and prognosis in malignant melanoma / Geilen, C.C. ... [et al.] -- Malignant melanoma - sentinel lymph node biopsy and surgical procedures / Kaufmann, R. -- The role of radiotherapy in malignant melanoma / Marnitz, S., Hoecht, S., Hinkelbein, W. -- Malignant melanoma: classification and staging of malignant melanoma / Eigentler, T.K., Garbe, C. -- Malignant melanoma: PET/CT as a staging procedure / Müller, S.P. -- Malignant melanoma - clinical development of peptide-based melanoma vaccines / Schmittel, A. ... [et al.].
  • Also available: Print – 2002
  • Also available: Print – 2008
  • In CT Colonography, Perry Pickhardt and David Kim present techniques for quicker evaluation and diagnosis of colon cancer through the pioneering, specialty-changing imaging technique of virtual colonoscopy (VC). This combination of sophisticated X-rays and CT scans of the abdomen offers patients an alternative to colonoscopy that is cost effective and reduces the need for unnecessary polyp removal. Abundantly illustrated in full color, this pioneering book describes CT colonography from pathogenesis, staging and treatment through indications, technique, and interpretation for the most common pathologies. Covers principles, techniques, and interpretations for the most common pathologies in a logical, practical organization. Presents tips from the authors on setting up a VC practice to provide a personal, instructive guide. Provides over 1000 full-color, high-resolution anatomic images throughout for the clearest, most accurate picture of colorectal cancer, its natural history, and its diagnosis by VC. Focuses on images, with the text serving as context for the proper use and understanding of VC.
  • Current and emerging therapeutics for multiple myeloma / Noopur Raje & Sundar Jagannath -- Current standard treatment of myeloma / Ray Powles & Arif Meghani -- Stem cell transplantation / Hermann Einsele -- New immune modulators / Loredana Santo & Noopur Raje -- Histone deacetylase inhibitors / Maurizio Zangari, Tamara Berno & Fenghuang Zhan -- Targeted treatment of multiple myeloma : proteasome inhibitors / Kristen M. Sanfilippo & Ravi Vij -- AKT inhibitors in multiple myeloma / R. Donald Harvey & Sagar Lonial -- Future directions / Klaus Podar -- Index.
  • Also available: Print – 2014
    "Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward."
  • Understanding brain metastasis -- Historical background -- Epidemiology of central nervous system metastases -- Histopathology of brain metastases after radiosurgery -- Radiobiological principles: their application to gamma knife therapy -- General management -- Imaging diagnosis of brain metastasis -- Surgical treatment of solitary brain metastases -- Whole-brain radiation therapy of brain metastasis -- Advances in radiation therapy of brain metastasis -- Role of chemotherapy on brain metastasis -- Radiosurgery for brain metastases -- Stereotactic radiosurgery for patients with metastatic brain tumors: development of a consensus radiosurgery guideline recommendation -- Radiosurgery -- Radiosurgical dose selection for brain metastasis -- Treatment of brain metastasis from lung cancer -- Gamma knife radiosurgery of brain metastasis from breast cancer -- Brain metastasis from renal cell carcinoma -- Stereotactic radiosurgery of brain metastasis from melanoma -- Gamma knife radiosurgery of other brain metastases -- Cyberknife radiosurgery for brain metastases -- Management of adverse radiation effects after radiosurgery -- Radiosurgery after craniotomy -- Combined role of whole-brain radiation therapy and radiosurgery for the treatment of brain metastasis -- Modern radiosurgery equipment for treating brain metastases -- Difficult cases -- Stereotactic radiosurgery for large brain metastases -- How many metastases can be treated with radiosurgery? -- Management of recurrent brain metastasis after radiosurgery -- Future perspectives of brain metastasis treatment -- Future perspectives of brain metastasis management.
  • Also available: Print – 2005
    Development of a conditional mouse model for head and neck squamous cell carcinoma / Bindels, E.M.J., van de Brekel, M.W.M. -- Hypofolatemia as a risk factor for head and neck cancer / Almadori, G. ... [et al.] -- Reduced DNA repair capacity in laryngeal cancer subjects: a comparison of phenotypic and genotypic results / Gajacka, M. ... [et al.] -- Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization / Götte, K. ... [et al.] -- Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck / Thurfjell, N. ... [et al.] -- p53, p63 and p73 expression in squamous cell carcinomas of the head and neck and their response to cisplatin exposure / Balz, V. ... [et al.] -- Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival / Wittekindt, C. ... [et al.] -- EGFR-antibody-supplemented TPF chemotherapy: preclinical investigations to a novel approach for head and neck cancer induction treatment / Knecht, R. ... [et al.] -- Nuclear factor kappa B as a common target and activator of oncogenes in head and neck squamous cell carcinoma / Chang, A.A., Van Waes, C. -- Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy / Riedel, F. ... [et al.] -- Expression pattern of chemokine receptors 6 and 7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype / Wang, J. ... [et al.] -- p53-based immunotherapy of cancer / De Leo, A.B. -- p53 as an immunotherapeutic target in head and neck cancer: approaches to reversing unresponsiveness of T lymphocytes and preventing tumor escape / Hoffmann, T.K. ... [et al.] -- Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease / Kuss, I. ... [et al.] -- Antitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccine / Herold-Mende, C. ... [et al.] -- Prognostic factors: confusion caused by bad quality of design, analysis and reporting of many studies / Sauerbrei, W.
  • Also available: Print – 2015
    Epidemiology of Gliomas -- Glioma biology and molecular markers -- Surgery for Gliomas-- Radiation therapy of Glioblastoma -- Low-grade Glioma -- Treatment of anaplastic Glioma -- Current medical treatment of Glioblastoma -- Novel chemotherapeutic approaches in adult high-grade Gliomas -- Immunotherapy for malignant Gliomas -- Glioblastoma in the elderly -- Palliative and supprotive care for Glioma patients.
  • Also available: Print – v. 2, 2006.
    v. 2 Unusual cases.
  • The Peripheral Nerve and Cutaneous Neural Tumors: Introduction, Definitions, and Classification -- Special Techniques for the Study of Cutaneous Neural Tumors -- Nonneoplastic and Hamartomatous Lesions of the Cutaneous Peripheral Nerve -- Benign Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Malignant Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Cutaneous Proliferations with Putative Neural Differentiation -- Cutaneous Neuroblastic and Ganglion Cell Proliferations -- Cutaneous Glial and Meningothelial Proliferations -- Appendix: Practical Approach to Neural Tumors? Flowcharts and Differential Diagnostic Table.
  • Also available: Print – 2005
  • Helicobacter pylori and cytokines in the genesis of gastric cancer / Richard M. Peek, Jr. -- HTLV-1, cytokines, and cancer / Michael Lairmore and Lee Ratner -- Herpesviruses, cytokines, and cancer / Frank J. Jenkins and Heather R. Hensler -- Tumor necrosis factor and cancer / Mark DeWitte ... [et al.] -- Transforming growth factor-[beta] and cancer / Alyssa R. Bonine-Summers, Brian K. Law, and Harold L. Moses -- Interleukin-1 family of cytokines and cancer / Michael T. Lotze--Interleukin-4/13 and cancer / Koji Kawakami and Raj K. Puri -- Interleukin-6 and Castleman's disease / Norihiro Nishimoto -- Interleukin-10 (IL-10): biology, immune, regulation, and cancer / Shin-ichiro Fujii and Michael T. Lotze -- Cytokines in multiple myeloma: therapeutic implications / Dharminder Chauhan, Teru Hideshima, and Kenneth C. Anderson -- In vivo murine cytokine models and the genesis of cancer / Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri -- Experimental models of cytokines and cancer prevention / Mark J. Smyth ... [et al.] -- Cytokines in the tumor stroma / Michael C. Ostrowski -- Cytokines and tumor angiogenesis / Sharmila Roy-Chowdhury and Charles K. Brown -- Chemokine and receptor expression in tumor progression / Paola Allavena, Federica Marchesi, and Alberto Mantovani -- The biology of cancer cachexia and the role of TNF-[alpha] / Denis C. Guttridge -- Interleukin-2 and cancer therapy / Kim Margolin and Joseph Clark -- Interleukin-12 and cancer therapy / Timothy E. Bael and Jared Gollob -- The type I interferon system with emphasis on its role in malignancies: interferons are more than "antivirals" / Stergios J. Moschos ... [et al.] -- Combination cytokine therapy / Seth M. Cohen and Howard L. Kaufman -- Novel strategies for cytokine administration via targetting / Paul M. Sondel ... [et al.] -- Cytokines and cancer vaccines / Hideho Okada and Michael T. Lotze -- Anticytokine therapy / Miguel A. Villalona-Calero -- Cytokines in the supportive care of cancer / John A. Glaspy.
  • Normal histology of female genital organs -- Lesions of the vulva and vagina -- Squamous lesions of the cervix -- Glandular lesions of the cervix -- Human papillomavirus for cervical pathology -- Endometrial epithelial neoplasms -- Nonepithelial tumors of uterine corpus -- Gestational trophoblastic disease -- Tumors of fallopian tube and broad ligament -- Epithelial neoplasms of ovary -- Nonepithelial tumor of ovary -- Tumors of peritoneum.
  • Also available: Print – 2014
    In recent decades, cytopathology has assumed an increasing role in the primary diagnosis of mass lesions owing to its ability to provide rapid, non-invasive, and timely information. With cytopathology at the forefront of diagnosis and prognostication of neoplastic lesions, it is essential that physicians involved in the diagnosis and treatment of precancerous lesions and cancer have a clear understanding of specimen collection techniques, terminology for reporting, and outcomes in various diagnostic categories. This book provides a comprehensive overview of the role of cytology at various body sites. The diagnostic details covered are abbreviated in comparison with those in pathology texts. Instead, a more clinical approach is taken, with the focus on the advantages and limitations of techniques and the key features of entities that are important to clinicians. Pathological clinical correlation is highlighted throughout the book, ensuring that it will be highly relevant for clinicians. In particular, physicians who deal with oncology patients will find it to be a rich source of guidance on how to use and understand cytopathology in the diagnosis and exclusion of malignancy.
  • & Quot;Soft Tissue Cytopathology" by Anil V. Parwani, MD, PhD and Walid E. Khalbuss, MD, PhD, will fulfill the need for an easy-to-use and authoritative synopsis of soft tissue cytopathology. This volume, part of "The Essentials in Cytopathology book series," fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Anil V. Parwani, MD, PhD, is Associate Professor of Pathology at the University of Pittsburgh Medical Center - S.
  • Cytopathological techniques for the diagnosis of glandular lesions of the genital tract -- Bethesda System Classification of glandular lesions on cervical cytology -- Cytopathology of the benign glandular lesions of the cervix and glandular cytopathology of the vagina -- Cytopathology of adenocarcinoma in situ of the endocervix and its differential diagnosis -- Cytopathology of the malignant invasive lesions of the endocervix -- Endometrial hyperplasias -- Endometrial adenocarcinoma : current status and future of prevention and early diagnosis -- Cytopathology of ovarian lesions : the intraoperative approach -- Glandular lesions of the vulva -- Glandular lesions of the fallopian tube -- Metastatic glandular lesions -- Ancillary techniques for the diagnosis of glandular lesions of the female genital tract
  • Print Material
    "The true story of the war on cancer from one of its generals In The Death of Cancer, Dr. Vincent T. DeVita Jr.--former director of the National Cancer Institute, former physician-in-chief at Memorial Sloan Kettering, director of the Yale Cancer Center, former president of the American Cancer Society, and developer of the first successful chemotherapy treatment for Hodgkin's lymphoma, which first demonstrated that advanced cancers of a major organ system in adults could be cured by chemotherapy--provides a personal history of one of the greatest science stories of our time, covering our fight against cancer from a man who's seen it all. But this is more than a history; it's also a work of advocacy. Despite declining mortality rates, DeVita argues, America's cancer patients are being shortchanged by timid doctors, misguided national agendas, and compromised bureaucracies. He gives readers an eye-opening look at the strengths and weaknesses of America's most prestigious cancer centers, showing how patients can use this information to their advantage. Though we're rapidly approaching total victory over cancer, he contends, we need to do more to synthesize our progress and help doctors put it into practice. This is an ambitious book about a life-or-death subject, a vital entry into the cancer literature genre. With historical depth and authenticity, DeVita brings important information to readers about what cancer is, how best to fight it, and what we still have to learn"-- Provided by publisher.
  • Also available: Print – 2009
    The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] -- FasL expression and reverse signaling / M. Lettau ... [et al.] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier.
  • v. 2, 2011 Springer
  • A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.
  • Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.
  • "In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the barriers to achieving excellent care for all cancer patients remain daunting. Care often is not patient-centered, many patients do not receive palliative care to manage their symptoms and side effects from treatment, and decisions about care often are not based on the latest scientific evidence. The cost of cancer care also is rising faster than many sectors of medicine--having increased to 125 billion in 2010 from 72 billion in 2004--and is projected to reach 173 billion by 2020. Rising costs are making cancer care less affordable for patients and their families and are creating disparities in patients' access to high-quality cancer care. There also are growing shortages of health professionals skilled in providing cancer care, and the number of adults age 65 and older--the group most susceptible to cancer--is expected to double by 2030, contributing to a 45 percent increase in the number of people developing cancer. The current care delivery system is poorly prepared to address the care needs of this population, which are complex due to altered physiology, functional and cognitive impairment, multiple coexisting diseases, increased side effects from treatment, and greater need for social support. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis presents a conceptual framework for improving the quality of cancer care. This study proposes improvements to six interconnected components of care: (1) engaged patients; (2) an adequately staffed, trained, and coordinated workforce; (3) evidence-based care; (4) learning health care information technology (IT); (5) translation of evidence into clinical practice, quality measurement and performance improvement; and (6) accessible and affordable care. This report recommends changes across the board in these areas to improve the quality of care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides information for cancer care teams, patients and their families, researchers, quality metrics developers, and payers, as well as HHS, other federal agencies, and industry to reevaluate their current roles and responsibilities in cancer care and work together to develop a higher quality care delivery system. By working toward this shared goal, the cancer care community can improve the quality of life and outcomes for people facing a cancer diagnosis."--Publisher's description.
  • The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • An Overview of Cutaneous Lymphomas -- Vascular Tumors -- Histiocytic Proliferations -- ʺFibrohistiocyticʺ Proliferations -- Tumors of Fat, Nerve, and Smooth Muscle -- Cutaneous Metastases -- Further Reading.
  • Elements of Cutaneous Embryology, Anatomy, and Biochemistry -- Classification of Cutaneous Lesions -- Hereditary Lesions -- Malformative Lesions -- Inflammatory Cutaneous Lesions -- Proliferative Cutaneous Lesions -- Miscellaneous Cutaneous Lesions.
  • Inflammatory disease of the dermis and epidermis / Maxwell A. Fung -- Panniculitis / Maxwell A. Fung -- Infectious diseases of the skin / Helen M. Chen, Anca G. Prundeanu Croitoru, Stefanie Hu, Hideko Kamino, Marcia Ramos-e-Silva, Klaus J. Busam -- Cutaneous vasculitis / Rami N. Al-Rohil, J. Andrew Carlson -- Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- Mucinoses, deposition disorders, and connective tissue alterations / Franco Rongioletti, Jacqueline Granese, Jacqueline Junkins-Hopkins, Luis Requena -- Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- Cysts and sinuses / Douglas R. Fullen -- Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- Adnexal tumors / Victor G. Prieto, Christopher R. Shea, Julide Tok Celebi, Klaus J. Busam -- Melanocytic proliferations / Klaus J. Busam -- Soft tissue tumors and tumor-like reactions / Darya Buehler, Steven D. Billings -- Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Melissa P. Pulitzer -- Histiocytic proliferative disorders / Bijal Amin, Melissa P. Pulitzer, Klaus J. Busam -- Cutaneous neuroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- Cutaneous metastases / Richard A. Scolyer, John F. Thompson, Annabelle Mahar, Rajmohan Murali -- Neoplastic and non-neoplastic disorders of the nail apparatus / Beth S. Ruben -- Neoplastic and non-neoplastic disorders of the conjunctiva and eyelid / Jasmine Francis, Klaus J. Busam, Brian Marr -- Evaluations of sections from Mohs surgery / Kishwer S. Nehal, Marie Tudisco, Klaus J. Busam.
  • Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 50% new clinical and dermoscopic images, valuable pearls and checklists, and you'll have everything you need to diagnose earlier and more accurately. Diagnose more accurately using the expanded section on testing tools for extra guidance on difficult cases. Gain a better visual understanding with approximately 50% new clinical and dermoscopic images that depict the appearance of benign and malignant lesions and feature arrows and labels to highlight important manifestations. Get better diagnostic results for less by learning how to successfully perform dermoscopy with this portable, to-the-point resource.
  • Desmoid tumors 2011
    Clinical Presentation of Desmoid Tumors -- Pathology of Desmoid Tumors -- APC/β-Catenin Deregulation in Desmoid Tumors: Important Implications for Diagnosis, Prognosis, and Therapy -- Imaging Techniques in Desmoid Tumors -- Surgical Management of Desmoid Tumors -- Systemic Therapy in the Treatment of Desmoid Tumors -- Radiation Therapy for Desmoid Tumors -- Interventional Radiology -- Introduction -- Desmoid Disease in Familial Adenomatous Polyposis -- Desmoid Tumor in Children and Adolescents: The Influence of Age -- Microarrays and High-Throughput Sequencing in Desmoid-Type Fibromatosis and Scar -- Desmoid Tumors: Are They Benign or Malignant? -- The Role of Patient Advocacy Groups in Rare Tumors Such as Desmoid Tumors.
  • Also available: Print – 2005
    The hedgehog signaling pathway in cancer / J. Vestergaard, Mads Bak, L.A. Larsen -- Rho GTPases and cancer / P. Buongiorno, B. Bapat -- Developmental biology of fibroblasts and neoplastic disease / D. Brouty-Boyé -- The extracellular matrix during normal development and neoplastic growth / J. Labat-Robert, L. Robert -- Wilms' tumor : starting off the kidney all over again? / M. Little -- Testicular teratomas : back to pluripotent stem cells / T. Kimura ... [et al.] / Tumor suppressors APC and VHL : gatekeepers of the intestine and kidney / R.H. Giles, E.E. Voest -- Hormonal and stromal regulation of normal and neoplastic prostatic growth / W.A. Ricke ... [et al.] -- Neoplastic growth through the developmental stages of the organism / A. Maciera-Coelho.
  • Also available: Print – v. 1-2., 2008
  • The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging -- Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas -- Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • "Cancer: Principles and Practice of Oncology presents the practicing oncologist with the practical as well as cutting-edge information needed to ensure the best possible care for each individual patient. To ensure a balanced multidisciplinary approach, a surgeon, a medical oncologist, and a radiation oncologist author each of the major treatment chapters. Each of the major treatment sections is preceded by an updated, brief chapter describing the molecular biology of that cancer and the prospects this new information holds for the improved management of cancer patients"--Provided by publisher.
  • This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-invasive modalities and presents algorithms to optimize and maximize sample collection and processing beginning at the time of tissue acquisition during the procedure. Secondly, the book provides an overview of the various existing and emerging lung cancer therapies and why a specific diagnosis is crucial. Key elements for the classification of small biopsies and cytology proposed by the ATS, IASLC, and ERS are highlighted. A section dedicated to immunohistochemistry offers a logical, step-by-step guide to sub-classify lung cancers and to differentiate them from metastases. The text also provides a review of the various molecular tests (and alternatives in cases of scant tissue) required for lung adenocarcinomas. Finally, potential pitfalls to avoid during acquisition, processing, and classification are discussed. With contributions from a team of multidisciplinary authors who are regularly involved in the care of lung cancer patients , Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology is an invaluable reference guide for pathologists, pathologists-in-training, and allied professionals, including oncologists, pulmonologists, surgeons, and radiologists.
  • This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio-oncologists, pathologists, and basic scientists. The remainder of the book focuses on areas of controversy in the diagnosis, treatment, and follow-up of testicular cancer. In each case the evidence base is discussed and results from the most recent studies are reviewed, drawing attention to new findings that might alter treatment recommendations. The treatment-related chapters cover a broad range of issues, including the best approach in patients with poor-prognosis and recurrent disease and those with long-term toxicities. Relevant aspects of survivorship care are also addressed. The book will help clinicians and practitioners to achieve the goals of minimizing therapy and its side-effects without reducing efficacy in low stage disease, improving the cure rate in advanced disease, and enhancing follow-up and long-term survivorship.
  • "A practical approach to the early detection and management of breast cancer. This lavishly illustrated atlas provides radiologists with essential information for the differential diagnosis of breast diseases on the basis of clinical presentation, mammography, and ultrasound. The book begins with chapters on tumor biology, prognostic factors, and histology. The authors then provide a thorough evaluation of various methods for early detection and accurate diagnosis, including analog and digital mammography, ultrasound, MR imaging, PET/CT, and interventional procedures. They discuss in detail the strengths and limitations of each imaging modality, aspects of quality control, test intervals, peri- and postoperative management principles, and follow-up care.Highlights:- Presentation of difficult cases that effectively demonstrate the diagnostic hurdles and forensic pitfalls in breast diagnosis- Special sections on breast cancer in men and young women, with discussion of women who are pregnant or lactating- Color-coded practical tips and clinical notes for optimal comprehension of the material- Extensive Q&A sections for self-testing in two major chapters - More than 1,700 high-quality illustrations, including clinical color photographs, ultrasound images, and mammograms"--Provided by publisher.
  • Small Sample Lung Biopsy Techniques in the Diagnosis of Airway and Parenchymal Lung Diseases -- Principles of Imagining Lung Disease -- Types of Biopsies -- Air Space Occupying Diseases -- Interstitial Lung Diseases in Small Lung Biopsies -- Diagnosis of Granulomatous Disease and Vasculitis in Small Lung Biopsies -- Benign Tumors of the Lung in Small Lung Biopsies -- Malignant Tumors of the Lung in Small Lung Biopsies.
  • Ephelides and Lentigo -- Melanocytic Nevus -- Congenital Nevus -- Spitz and Reed Nevus -- Dysplastic Nevus -- Dermal Melanocytoses -- Melanoma General -- Melanoma Variants -- Oral Mucosa Pigmented Lesions -- Conjunctival Melanocytic Lesions.
  • Vol. I: Introduction -- Tumors of the heart and pericardium -- Vascular tumors -- Tumors of the upper respiratory tract -- pt. A: Nasal cavity, paranasal sinuses, and nasopharynx -- pt. B: Larynx, hypopharynx, and trachea -- Tumors of the lung and pleura -- Tumors of the oral cavity -- Tumors of the salivary glands -- Tumors of the esophagus and stomach -- Tumors of the small and large intestines, including anal canal -- Tumors of the liver, biliary tree, and gallbladder -- Tumors of the exocrine pancreas -- Tumors of the urinary tract -- pt. A: Tumors of the kidney -- pt. B: Tumors of the renal pelvis and ureter -- pt. C: Tumors of the urinary bladder and urethra -- Tumors of the female genital tract -- pt. A: Ovary, fallopian tube, and broad and round ligaments -- pt. B: Endometrial tumors -- pt. C: Tumors of the placenta and gestational trophoblastic disease -- pt. D: Myometrium -- pt. E: Cervix -- pt. F: Vagina -- pt. G: Vulva -- Tumors and tumor-like conditions of the male genital tract -- pt. A: Prostate and seminal vesicles -- pt. B: Testicular neoplasms -- pt. C: Penis and scrotum -- Tumors of the peritoneum -- Vol. II: Tumors of the breast -- Tumors of the pituitary gland -- Tumors of the thyroid and parathyroid glands -- pt. A: The thyroid gland -- pt. B: The parathyroid gland -- Tumors of the adrenal gland -- Tumors of the endocrine pancreas -- Tumors of the lymphoreticular system, including spleen and thymus -- pt. A: The lymph node -- pt. B: The spleen -- pt. C: The thymus -- Tumors of the hematopoietic system -- Tumors of the skin -- Tumors of soft tissue -- Tumors of the osteoarticular system -- Tumors of the central nervous system -- Peripheral neuroectodermal tumors -- Tumors of the autonomic nervous system, including paraganglia -- Tumors of the eye and ocular adnexae -- Tumors of the ear -- Molecular genetic techniques in diagnosis and prognosis
  • Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • Morphologic Patterns -- Common Diagnostic Discrepancies -- Frozen Section of Ovarian Lesions -- Surface Epithelial Tumors: Pathology Introduction -- Surface Epithelial Tumors: Clinical Introduction -- Pathology of Serous Tumors -- Pathology of Endometrioid Tumors -- Pathology of Clear Cell Tumors -- Pathology of Mucinous Tumors -- Uncommon Epithelial Ovarian Tumors -- Metastatic Tumors -- Germ Cell and Sex Cord Stromal Tumors: Clinical Introduction -- Pathology of Germ Cell Tumors -- Sex Cord Stromal Tumors of the Ovary -- Pathology of Mesenchymal and Hematopoietic Tumors -- Tumors of Uncertain Histogenesis -- Fallopian Tube and Peritoneum -- Familial Cancer and Prophylactic Surgery -- Peritoneal Cytology.
  • Diagnostic Imaging of Lung and Pleural Tumors -- The Staging of Lung Cancer -- Non-Small Cell Carcinomas -- Neuroendocrine Carcinomas -- Biphasic Tumors of the Lungs -- Salivary Gland and Adnexal Type Tumors of the Lungs -- Tumors Derived from Presumed Ectopic Tissues -- Vascular Tumors of the Lungs -- Mesenchymal Tumors of the Lungs -- Lung Tumors of Uncertain Histogenesis -- Malignant Lymphomas Involving Lung and Pleura -- Tumors of the Pleura -- Tumor-like Conditions and Benign Tumors of the Lung -- Molecular Pathology of Lung Cancer.
  • This new text examines common as well as more difficult diagnostic problems encountered in today's field of breast pathology. The first part of each major section consists of a presentation of general concepts and a detailed description of the pathologic characteristics of specific lesions. Then it focuses on the differences between commonly confused entities and emphasizes pathologic findings to help you obtain the most accurate diagnosis. More than 1,000 illustrations-most in full color-present the key aspects of various diseases in real-life detail.
  • 1. Gene Signatures and Soft Tissue Sarcomas: Status of Art and Perspectives / Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini -- 2. Heterogeneity of Breast Cancer: Gene Signatures and Beyond / Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens -- 3. Gene Signatures in CRC and Liver Metastasis / Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo -- 4. Gene Signatures in Gastrointestinal Stromal Tumors / Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybył, and Maria Debiec-Rychter -- 5. Pancreatic Cancer Genetics / Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti -- 6. Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer / Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei -- 7. Gene Signatures in Gastric Cancer / Laura Ottini, Mario Falchetti, and Gabriella Nesi -- 8. Gene Signatures in Colorectal Cancer / Alessandro Lugli and Inti Zlobec -- 9. The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays / Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia -- 10. Primary Epithelial Ovarian Neoplasms: New Concepts Concerning Origin, Pathogenesis and Classification Based on Morphology, Immunomarkers, Molecular Features, and Gene Expression Studies / Bernard Czernobilsky, Leonor Leider-Trejo, Daniele Fanale, and Antonio Russo -- 11. Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns / Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone.
  • This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you'll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout. Expert Consult functionality allows you to access the entire contents of the book online, from any internet connection. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Features more than 1700 full-color illustrations that capture the pathologic and cytopathologic appearances of the full range of common and rare neoplastic and non-neoplastic lesions. Allows you to access the entire contents of the book online, from any internet connection, via Expert Consult functionality.
  • Diet and cancer v. 1-, 2010-
  • Also available: Print – 2007
    Radiologic and pathologic approach to bone tumors -- Bone-forming (osteogenic) lesions -- Cartilage (chondrogenic) lesions -- Fibrogenic, fibroosseous, and fibrohistiocytic lesions -- Round cell lesions -- Vascular lesions -- Miscellaneous tumors and tumor-like lesions -- Metastases -- Tumors and tumor-like lesions of the joints.
  • The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life. Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualized therapy for this kind of tumor. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book. This book uniquely focuses on addressing diffuse low-grade gliomas in adults and is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
  • This volume is the most up-to-date text available on diffuse malignant mesothelioma and includes all the newest imaging modalities, immunohistochemical features, and ever-expanding information on the molecular characteristics of the cancer. In-depth chapters contain fully referenced text as well as detailed tables and images. While the primary audiences for this book are pathologists and pathology residents, the broad examination of diffuse malignant mesothelioma, including its epidemiology, makes this book valuable to radiologists, surgeons, oncologists, and other clinical physicians and their residents as well. Written by experts in the field, Diffuse Malignant Mesothelioma is a concise yet comprehensive resource for clinicians involved in the management of one of the most widely recognized and feared cancers in the world.
  • SECTION I BREAST ANATOMY AND DEVELOPMENT -- ch. 1 Breast Anatomy and Development / Susan K. Boolbol -- ch. 2 Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives / Max S. Wicha -- SECTION II DIAGNOSIS AND MANAGEMENT OF BENIGN BREAST DISEASE -- ch. 3 Physical Examination of the Breast / Monica Morrow -- ch. 4 Management of the Palpable Breast Mass / Richard J. Bleicher -- ch. 5 Management of Disorders of the Ductal System and Infections / Nigel J. Bundred -- ch. 6 Management of Breast Pain / Robert E. Mansel -- ch. 7 Abnormalities of the Breast in Pregnancy and Lactation / Holly S. Mason -- ch. 8 Management of Gynecomastia / Glenn D. Braunstein -- ch. 9 Pathology of Benign Breast Disorders / Stuart J. Schnitt -- SECTION III BREAST IMAGING AND IMAGE-GUIDED BIOPSY TECHNIQUES -- ch. 10 Breast Cancer Screening / Joann G. Elmore -- ch. 11 Imaging Analysis: Mammography / Stephanie K. Patterson -- ch. 12 Imaging Analysis: Ultrasonography / Emily L. Sedgwick -- ch. 13 Imaging Analysis: Magnetic Resonance Imaging / Susan Orel Roth -- ch. 14 New Breast Imaging Techniques / Maxine S. Jochelson -- ch. 15 Image-Guided Biopsy of Nonpalpable Breast Lesions / Christopher E. Comstock -- SECTION IV EPIDEMIOLOGY AND ASSESSING AND MANAGING RISK -- ch. 16 Inherited Genetic Factors and Breast Cancer / Alan Ashworth -- ch. 17 Genetic Testing and Management of Patients with Hereditary Breast Cancer / Claudine Isaacs -- ch. 18 Nongenetic Factors in the Causation of Breast Cancer / Graham A. Colditz -- ch. 19 Management of Other High Risk Patients / Seema A. Khan -- ch. 20 Chemoprevention / Powel H. Brown -- SECTION V IN SITU CARCINOMA -- ch. 21 Ductal Carcinoma In Situ and Other Intraductal Lesions: Pathology, Immunohistochemistry, and Molecular Alterations / Edi Brogi -- ch. 22 Lobular Carcinoma In Situ: Biology and Management / Jorge S. Reis-Filho -- ch. 23 Ductal Carcinoma In Situ and Microinvasive Carcinoma / Jay R. Harris -- SECTION VI PATHOLOGY AND BIOLOGICAL MARKERS OF INVASIVE BREAST CANCER -- ch. 24 Genomic Events in Breast Cancer Progression / Matthew J. Ellis -- ch. 25 Pathology of Invasive Breast Cancer / Stuart J. Schnitt -- ch. 26 Estrogen and Progesterone Receptor Testing for Prognosis and Prediction / William Miller -- ch. 27 HER2/ERBB2 Testing: Assessment of Status for Targeted Therapies / Yanling Ma -- ch. 28 Clinical and Pathologic Prognostic and Predictive Factors 6 / Frederick L. Moffat -- ch. 29 Genomics, Prognosis, and Therapeutic Interventions / Charles M. Perou -- ch. 30 Bone Marrow Micrometastases and Circulating Tumor Cells / Daniel F. Hayes -- SECTION VII MANAGEMENT OF PRIMARY INVASIVE BREAST CANCER -- ch. 31 Evaluation of Patients for Metastasis Prior to Primary Therapy / C. Kent Osborne -- ch. 32 Staging of Breast Cancer / Jay R. Harris -- ch. 33 Mastectomy / Mehra Golshan -- ch. 34 Contralateral Prophylactic Mastectomy / Todd M. Tuttle -- ch. 35 Breast-Conserving Therapy / Monica Morrow -- ch. 36 Breast Reconstruction / Alice Y. Ho -- ch. 37 Sentinel Lymph Node Biopsy / Armando E. Giuliano -- ch. 38 Axillary Dissection / George Plitas -- ch. 39 Preserving and Restoring Function after Local Treatment / Andrea L. Cheville -- ch. 40 Lymphedema / Sarah A. Mclaughlin -- ch. 41 Local Management of the Axilla / Jay R. Harris -- ch. 42 Postmastectomy Radiation Therapy / Bruce G. Haffty -- ch. 43 Adjuvant Systemic Therapy: Endocrine Therapy / C. Kent Osborne -- ch. 44 Adjuvant Systemic Chemotherapy in Early Breast Cancer / Clifford A. Hudis -- ch. 45 Adjuvant Chemo Endocrine Therapy / Nancy E. Davidson -- ch. 46 Adjuvant and Preoperative Systemic Therapy for HER2-Positive Breast Cancer / Eric P. Winer -- ch. 47 Adjuvant Systemic Therapy: Bone-Targeted Treatments / Robert E. Coleman -- ch. 48 Pharmacogenomics of Systemic Therapy / James M. Rae -- ch. 49 Implications of Obesity in Breast Cancer / Andrew J. Dannenberg -- ch. 50 Lifestyle Issues in Breast Cancer Survivors / Rowan T. Chlebowski -- ch. 51 Management of Menopausal Symptoms in Breast Cancer Survivors / Charles L. Loprinzi -- ch. 52 Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies / Patricia A. Ganz -- ch. 53 Adjuvant Systemic Therapy Treatment Guidelines / C. Kent Osborne -- SECTION VIII PREOPERATIVE SYSTEMIC THERAPY -- ch. 54 Preoperative Chemotherapy for Operable Breast Cancer / Jose Baselga -- ch. 55 Preoperative Endocrine Therapy for Operable Breast Cancer / Ian E. Smith -- ch. 56 Pathologic Assessment of Treatment Response after Neoadjuvant Therapy / Susan Carole Lester -- ch. 57 Local-Regional Therapy following Systemic Treatment / Kelly K. Hunt -- ch. 58 Locally Advanced Breast Cancer / Eric A. Strom -- ch. 59 Inflammatory Breast Cancer / Lori J. Pierce -- ch. 60 Preoperative Systemic Therapy for Breast Cancer / Marc E. Lippman -- SECTION IX SPECIAL THERAPEUTIC PROBLEMS -- ch. 61 Male Breast Cancer / William J. Gradishar -- ch. 62 Phyllodes Tumors / Benjamin O. Anderson -- ch. 63 Paget's Disease / Nora M. Hansen -- ch. 64 Nonepithelial Malignancies of the Breast / Carolina Gutierrez -- ch. 65 Breast Cancer during Pregnancy and Subsequent Pregnancy in Breast Cancer Survivors / Richard L. Theriault -- ch. 66 Occult Primary Cancer with Axillary Metastases / Youlia M. Kirova -- SECTION X EVALUATION AFTER PRIMARY THERAPY AND MANAGEMENT OF RECURRENT BREAST CANCER -- ch. 67 Surveillance of Patients following Primary Therapy / Robert W. Carlson -- ch. 68 Surgery for the Primary in Patients with Distant Metastases / Tari A. King -- ch. 69 Management of Local Regional Recurrences after Primary Breast Cancer Treatment / Erica L. Mayer -- ch. 70 Treatment of Metastatic Breast Cancer: Endocrine / Gaia Schiavon -- ch. 71 Treatment of Metastatic Breast Cancer: Chemotherapy / Antonio C. Wolff -- ch. 72 Treatment of HER2-overexpressing Metastatic Breast Cancer / Mark D. Pegram -- ch. 73 Palliative Care in Breast Cancer / Thomas J. Smith -- ch. 74 Management Summary for the Care of Patients with Metastatic Breast Cancer / Marc E. Lippman -- SECTION XI NEW BREAST CANCER THERAPEUTIC APPROACHES -- ch. 75 Newer Targeted Therapy / Carlos L. Arteaga -- SECTION XII SITE-SPECIFIC THERAPY OF METASTATIC BREAST CANCER -- ch. 76 Brain Metastases / Ian F. Dunn -- ch. 77 Metastatic Epidural Spinal Cord Compression / Patrick Y. Wen -- ch. 78 Leptomeningeal Metastasis / Lisa M. Deangelis -- ch. 79 Brachial Plexopathy in Patients with Breast Cancer / Pauline T. Truong -- ch. 80 Ophthalmic Metastases / David H. Abramson -- ch. 81 Management of Isolated Liver Metastases / Steven Come -- ch. 82 Medical Treatment for Bone Metastases / Christy A. Russell -- ch. 83 Local Management of Bone Metastases / James A. Hayman -- SECTION XIII BREAST CANCER IN SPECIAL POPULATIONS -- ch. 84 Breast Cancer in Older Women / Hyman B. Muss -- ch. 85 Breast Cancer in Younger Women / Richard D. Gelber -- ch. 86 Breast Cancer in Minority Women / Lisa A. Carey -- SECTION XIV ISSUES IN BREAST CANCER SURVIVORSHIP -- ch. 87 Nursing Care in Patient Management and Quality of Life / Deborah K. Walker -- ch. 88 Overview of Survivorship Issues / Larissa Nekhlyudov -- ch. 89 Psychosocial Adaptation during and after Breast Cancer / Mary Jane Massie -- ch. 90 Reproductive Issues in Breast Cancer Survivors / Elizabeth S. Ginsburg -- ch. 91 Cost and Cost Effectiveness Considerations / Bruce E. Hillner
  • Breast anatomy and development -- Molecular mechanisms regulating breast development -- Stem cells in breast development and carcinogenesis: concepts and clinical perspectives -- Physical examination of the breast -- Management of the palpable breast mass -- Management of disorders of the ductal system and infections -- Management of breast pain -- Abnormalities of the breast in pregnancy and lactation -- Management of gynecomastia -- Pathology of benign breast disorders -- Screening for breast cancer -- Imaging analysis: mammography -- Breast ultrasound -- Imaging analysis: magnetic resonance imaging -- Imaging: new techniques -- Image-guided biopsy of nonpalpable breast lesions -- Management summary on breast imaging -- Inherited genetic factors and breast cancer -- Genetic testing and management of patients with hereditary breast cancer -- Nongenetic factors in the causation of breast cancer -- Management of other high risk patients -- Chemoprevention: clinical aspects -- Pathology and biological features of premalignant breast disease -- Lobular carcinoma in situ: biology and pathology -- Lobular carcinoma in situ: clinical management -- Ductal carcinoma in situ and microinvasive carcinoma -- Breast cancer genomics -- Pathology of invasive breast cancer -- Clinical aspects of estrogen and progesterone receptors -- ERBB2 testing: assessment of status for targeted therapies -- Prognostic and predictive markers -- Gene arrays, prognosis, and therapeutic interventions -- Bone marrow micrometastases and circulating tumor cells -- Evaluation of patients for metastasis prior to primary therapy -- Staging of breast cancer -- Mastectomy -- Breast-conserving therapy: conventional whole breast irradiation -- Breast-conserving therapy: accelerated partial breast irradiation -- Breast reconstruction -- Local therapy for the breast and chest wall -- Sentinel lymph node dissection -- Axillary dissection -- Axillary irradiation -- Preserving and restoring function after local treatment -- Lymphedema -- Treatment of the axilla and other regional nodes -- Postmastectomy radiation therapy -- Adjuvant systemic therapy: endocrine therapy -- Adjuvant systemic therapy: chemotherapy -- Adjuvant systemic therapy: chemoendocrine -- Adjuvant treatment of ERBB2 positive breast cancer -- Adjuvant systemic therapy: bisphosphonates -- Lifestyle issues in breast cancer survivors -- Management of menopausal symptoms in breast cancer survivors -- Side effects of systemic therapy: neurocognitive, cardiac, and secondary malignancies -- Pharmacogenomics of systemic therapy of breast cancer -- Guidelines for adjuvant systemic therapy -- Preoperative therapy for operable breast cancer -- Preoperative endocrine therapy for operable breast cancer -- Local-regional therapy considerations in patients receiving preoperative chemotherapy -- Locally advanced breast cancer -- Inflammatory breast cancer -- Management summary on preoperative systemic therapy -- Male breast cancer -- Phyllodes tumors -- Paget's disease -- Nonepithelial malignancies of the breast -- Breast cancer during pregnancy and subsequent pregnancy in breast cancer survivors -- Occult primary cancer with axillary metastases -- Surveillance of patients following primary therapy -- Surgery for the primary in patients with distant metastases -- Local-regional recurrence after breast-conservation treatment or mastectomy -- Treatment of metastatic breast cancer: endocrine therapy -- Treatment of metastatic breast cancer: chemotherapy -- Treatment of HER2-overexpressing metastatic breast cancer -- End-of-life considerations in patients with breast cancer -- Management summary for metastatic disease for the care of patients with metastatic disease -- Angiogenesis inhibition in breast cancer -- Tyrosine kinase inhibitors -- Newer targeted therapy in breast cancer -- Brain metastases -- Epidural metastases -- Leptomeningeal metastasis -- Brachial plexopathy in patients with breast cancer -- Ocular metastases -- Malignant effusions -- Management of discrete pulmonary nodules -- Management of lsolated liver metastases -- Bone-directed therapy and breast cancer: bisphosphonates, monoclonal anitbody, and radionuclides -- Local management of bone metastases -- Breast cancer in older women -- Breast cancer in younger women -- Breast cancer in minority women -- Nursing care in patient management and quality of life -- Psychosocial adaptation during and after breast cancer -- Reproductive issues in breast cancer survivors -- Medical legal aspects of breast cancer evaluation -- Cost and cost-effectiveness considerations.
  • Also available: Print – 2010
    The HIF-2[alpha]-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization / A. Pietras, A.S. Johnsson and S. Pahlman -- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance / Z. Li and J.N. Rich -- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression / A.J. Giaccia and E. Schipani -- The role of hypoxia regulated microRNAs in cancer / R. McCormick ... [et al.] -- Oxygen sensing: A common crossroad in cancer and neurodegeneration / A. Quaegebeur and P. Carmeliet -- Hypoxia-inducible factors as essential regulators of inflammation / H.Z. Imtiyaz and M.C. Simon -- Hypoxia and metastasis in breast cancer / H. Rundqvist and R.S. Johnson.
  • Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
  • DNA and RNA nanobiotechnologies have currently reached the status of one of the most dynamic research areas in the field of drug delivery in molecular medicine. Scientists and bio-engineers are creating totally new nanometer-scale structures with unique biological properties for a wide range of medical applications. The book, written by world-leading scientists in this new field, gives an overview of various aspects and applications of DNA and RNA nanotechnologies. These include the design and synthesis of DNA and RNA nanostructures with the aim of using them for different kinds of drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, siRNA delivery for cancer treatment, and even analytical and therapeutic applications of aptamer-based nanoparticles. This volume will be of interest not only to graduate students and researchers in the field of molecular medicine and molecular biology, but also to chemists interested in the biological fields. As a matter of fact, the book contains so many new and unique approaches to this area of molecular medicine that it may inspire the interested reader to undertake research into nucleic acid nanotechnologies.
  • DNA Damage Sensing and Signaling / Daniel Durocher -- Signaling at Stalled Replication Forks / Daniel A. Mordes and David Cortez -- An Oncogene-Induced DNA Replication Stress Model for Cancer Development / Thanos D. Halazonetis -- Cellular Responses to Oxidative Stress / Inbal Dar and Ari Barzilai -- Cell Cycle Regulation and DNA Damage / Ryo Sakasai and Randal S. Tibbetts -- Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks / Julia Pagan, Emma Bolderson, Mathew Jones and Kum Kum Khanna -- Telomere Metabolism and DNA Damage Response / Tej K. Pandita -- DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential / Laura M. Williamson, Chris T. Williamson and Susan P. Lees-Miller -- DNA Base Excision Repair: A Recipe for Survival / Rabindra Roy and Sankar Mitra -- DNA Damage Tolerance and Translesion Synthesis / Alan R. Lehmann -- Nucleotide Excision Repair: from DNA Damage Processing to Human Disease / Mischa G. Vrouwe and Leon H.F. Mullenders -- Chromosomal Single-Strand Break Repair / Keith W. Caldecott -- Mouse Models of DNA Double Strand Break Repair Deficiency and Cancer / Sachin Katyal and Peter J. McKinnon -- Cancer Biomarkers Associated with Damage Response Genes / Anne E. Kiltie, Marie Fernet and Janet Hall -- Linking Human RecQ Helicases to DNA Damage Response and Aging / Wen-Hsing Cheng, Byungchan Ahn and Vilhelm A. Bohr -- Single-Stranded DNA Binding Proteins Involved in Genome Maintenance / Derek J. Richard and Kum Kum Khanna -- The Fanconi anemia-BRCA Pathway and Cancer / Toshiyasu Taniguchi -- BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment / Kienan Savage and D. Paul Harkin.
  • DNA methylation : three decades in search of function / Aharon Razin -- Epigenetic mechanisms of gene regulation : relationships between DNA methylation, histone modification, and chromatin structure / Keith D. Robertson -- DNA hypo- vs. hypermethylation in cancer : tumor specificity, tumor progression, and therapeutic implications / Melanie Ehrlich and Guanchao Jiang -- DNA methylation in urological cancers / Wolfgang A. Schulz and Hans-Helge Seifert -- DNA methylation in colorectal cancer / Jeremy R. Jass ... [et al.] -- CpG island hypermethylation of tumor suppressor genes in human cancer : concepts, methodologies and uses / Michel Herranz and Manel Esteller -- The loss of methyl groups in DNA of tumor cells and tissues : the immunochemical approach / Alain Niveleau ... [et al.] -- Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays / Susan H. Wei ... [et al.] -- Methylation analysis in cancer : (epi)genomic fast track from discovery to clinical routine / Carolina Haefliger, Sabine Maier and Alexander Olek -- Regulation of DNA methyltransferases in cancer / Nancy Detich and Moshe Szyf -- Inhibition of poly(ADP-ribosyl)ation allows DNA hypermethylation / Anna Reale ... [et al.] -- The role of active demethylation in cancer and its therapeutic potential / Moshe Szyf ... [et al.] -- Purine analogues and their role in methylation and cancer chemotherapy / Katherine L. Seley and Sylvester L. Mosley -- DNA methyltransferase inhibitors : paving the way for epigenetic cancer therapeutics / Gregory K. Reid and A. Robert MacLeod -- Preclinical and clinical studies on 5-aza-2'-deoxycytidine, a potent inhibitor of DNA methylation, in cancer therapy / Richard L. Momparler -- Anticancer gene therapy by in vivo DNA electrotransfer of MBD2 antisense / Pascal Bigey and Daniel Scherman.
  • Also available: Print – 2006
    Regulation of chromatin and DNA-methylation patterns in blood cell development / C. Bonifer, P. Lefevre, and H. Tagoh -- Methylation dynamics in the early mammalian embryo : implications of genome reprogramming defects for development / T. Haaf -- Epigenetic regulation in drosophila / F. Lyko ... [] -- Epimutations in human disease / B. Horsthemke -- Epigenotypes of latent herpesvirus genomes / J. Minarovits -- Epigenetics of complex diseases : from general theory to laboratory experiments / A. Schumacher and A. Petronis -- MSL proteins and the regulation of gene expression / S. Rea and A. Akhtar -- DNA methylation profiles of female steroid hormone-driven human malignancies / M. Campan, D.J. Weisenberger, and P.W. Laird -- Genome-wide analysis of DNA methylation changes in human malignancies / C. Plass and D.J. Smiraglia -- Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island / N. Watanabe ... [] -- Methylation of endogenous human retroelements in health and disease / W. A. Schulz, C. Steinhoff, and A.R. Florl -- Cancer-linked DNA hypomethylation and its relationship to hypermethylation / M. Ehrlich.
  • 2012 ClinicalKey
    Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
  • The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
  • Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina ... [et al.] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev ... [et al.] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir ... [et al.] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico ... [et al.] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer ... [et al.] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss ... [et al.] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier.
  • General considerations -- Clinical considerations and imaging of bone tumors / Colleen M. Costelloe and John E. Madewell -- Molecular biology of bone tumors -- Benign osteoblastic tumors -- Osteosarcoma -- Benign cartilage lesions -- Malignant cartilage tumors -- Fibroosseous lesions -- Fibrous and fibrohistiocytic lesions -- Giant-cell lesions -- Ewing's sarcoma and related entities -- Hematopoietic tumors / April Ewton -- Vascular lesions -- Neurogenous tumors and neurofibromatosis affecting bone / Gregory N. Fuller -- Cystic lesions -- Miscellaneous mesenchymal tumors -- Adamantinoma of long bone -- Chordoma and related lesions -- Metastic tumors in bone / John D. Reith -- Synovial lesions -- Sclerosing bone lesions -- Tumor-induced osteomalacia and rickets -- Reactive and metabolic conditions simulating neoplasms of bone -- Precancerous conditions.
  • 1. Drug evaluations in pancreatic cancer culture systems -- 2. Mouse xenograft models for drug discovery in pancreatic cancer -- 3. Flourescent metastatic mouse models of pancreatic cancer for drug discovery -- 4. A new preclinical paradigm for pancreas cancer -- 5. Zebrafish as a biological system for identifying and validating therapeutic targets and compounds -- 6. Gene expression arrays in pancreatic cancer drug discovery research -- 7. Using array comparative genomic hybridization of pancreatic cancer samples to map interesting regions for target gene identification -- 8. The application of high-throughput RNAi in pancreatic cancer target discovery and drug development -- 9. MicroRNA a profiling and its application in drug discovery in pancreatic cancer -- 10. Methylation detection and epigenomics in pancreatic cancer -- 11. Tissue microarray applications in drug discovery for pancreatic cancer -- 12. Proteomic analysis of blood and pancreatic juice -- 13. Applications of antibody-lectin sandwich arrays (ALSA) to pancreatic cancer diagnostics and drug discovery -- 14. The development of pharmacodynamic endpoint models for evaluation of therapeutic in pancreatic cancer -- Index.
  • Cell Biology of Prostate Cancer and Molecular Targets / Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang -- Part I. Hormone Therapy. Luteinizing Hormone-Releasing Hormone and its Agonistic, Antagonistic, and Targeted Cytotoxic Analogs in Prostate Cancer / Andrew V. Schally and Norman L. Block ; Nuclear Receptor Coregulators: Promising Therapeutic Targets for the Treatment of Prostate Cancer / Hannelore V. Heemers and Donald J. Tindall ; Androgens and Prostate Cancer / Douglas K. Price and Ann W. Hsing ; Androgen Receptor Biology in Prostate Cancer / Edward P. Gelmann ; Androgen Receptor Antagonists / Howard C. Shen, Mary-Ellen Taplin, and Steven P. Balk ; 5-Alpha Reductase Inhibitors in Prostate Cancer / Zoran Culig ; Adrenal Androgen Synthesis Inhibitor Therapies in Castration-Resistant Prostate Cancer / Terence W. Friedlander and Charles J. Ryan ; Androgen Deprivation Therapy / Nima Sharifi ; Pharmacogenetics of the Androgen Metabolic Pathway / Francine Zanchetta Coelho Marques, and Juergen K.V. Reichardt -- Part II. Chemotherapy. Mitoxantrone / Patricia Halterman, Nicholas J. Vogelzang, Alireza Farabishahadel, and Oscar B. Goodman Jr. ; Docetaxel / Courtney K. Phillips and Daniel P. Petrylak ; Beyond Docetaxel: Emerging Agents in the Treatment of Advanced Prostate Cancer / Jonathan Rosenberg ; Platinum Agents in Prostate Cancer / Ashley Brick, Junyang Niu, Jiaoti Huang, and William K. Oh ; Clinical Pharmacology and Pharmacogenetics of Chemotherapy in Prostate Cancer / Tristan M. Sissung and William D. Figg ; Microtubule Targeting Agents / Antonio Tito Fojo and David E. Adelberg -- Part III. Angiogenesis. Principles of Antiangiogenic Therapy / Cindy H. Chau and William D. Figg ; Bevacizumab in Advanced Prostate Cancer / Aymen A. Elfiky and William Kevin Kelly ; Thalidomide and Analogs / Erin R. Gardner, Giuseppe Di Lorenzo, and William D. Figg ; Investigational Angiogenesis Inhibitors / Jeanny B. Aragon-Ching and William Dahut ; Pharmacogenetics of Angiogenesis / Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Francesco Crea, Mario Del Tacca, and Romano Danesi -- Part IV. Bone Metastasis. Pathophysiology of Prostate Cancer Bone Metastasis / Evan T. Keller and Christopher L. Hall ; Radiopharmaceuticals / Oliver Sartor and Damerla R. Venugopal ; Bisphosphonates for Prevention and Treatment of Bone Metastases / Philip J. Saylor and Matthew R. Smith ; Endothelin Receptors as Therapeutic Targets in Castration-Resistant Prostate Cancer / Joel B. Nelson ; Calcitriol and Vitamin D Analogs / Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, and Edwin M. Posadas -- Part V. Immunotherapy. Cancer Immunology, Immunotherapeutics, and Vaccine Approaches / Ravi A. Madan, James L. Gulley, Jackie Celestin, Philip M. Arlen, and Jeffrey Schlom ; Sipuleucel-T (APC8015): Active Cellular Immunotherapy for Advanced Metastatic Castration-Resistant Prostate Cancer / Celestia S. Higano and Mark W. Frohlich ; GM-CSF Gene-Transduced Prostate Cancer Vaccines: GVAX / Lalit R. Patel and Jonathan W. Simons ; CTLA-4 Blockade for Prostate Cancer Treatment / Andrea L. Harzstark and Lawrence Fong -- Part VI. Prevention. Prostate Cancer Chemoprevention Strategies / Howard L. Parnes, Margaret G. House, and Joseph A. Tangrea ; Diet and Prostate Cancer Incidence, Recurrence, and Progression Risk / June M. Chan and Erin L. Richman ; Inflammation as a Target in Prostate Cancer / Marshall Scott Lucia, James R. Lambert, Elizabeth A. Platz, and Angelo M. De Marzo -- Part VII. Drug Development. Challenges for the Development of New Agents in Prostate Cancer / Ajjai S. Alva, Deborah A. Bradley, and Maha Hussain ; FDA Approval of Prostate Cancer Treatments / Yang-Min Ning, Ramzi N. Dagher, and Richard Pazdur ; Applications of Proteomics in Prostate Cancer / Mitchell Gross, Edward Macrohon Nepomuceno, and David B. Agus.
  • Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakács ... [et al.] -- Metastasis and Drug Resistance / Dominic Fan ... [et al.] -- The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama ... [et al.] -- Mechanisms of Resistance to targeted Tyrosine Kinase Inhibitors / Stacey J.Baker, E. Premkumar Reddy -- Targeting Transglutaminase-2 to overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- Extracellular Matrix-Mediated Drug Resistance / P.S. Hodkinson, Tariq Sethi -- Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- Nuclear Factor-kB and Chemoresistance / Ajaikumar B.Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- Drug Resistance and the Tumor Suppressor p53 : The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- Resistance to Differentiation Therapy / Bulent Ozpolat -- MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong.
  • "Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting."
  • The aim of this book is fourfold: to describe the basic principles of Dual Energy CT (DECT) imaging, to explain how post-processing is utilized, to critically appraise the strengths and weaknesses of the technique in oncologic imaging, and above all, to demonstrate the contribution of DECT in the management of oncologic patients. Information is provided on the practice and interpretation of DECT and its impact on clinical decision making in a variety of oncological settings, including tumors of the head and neck, lung, liver, pancreas, gastrointestinal system, kidney, and musculoskeletal system. DECT is an innovative imaging technique in which the application of two distinct energy settings provides a transition from density-based image to spectral imaging. As detailed in this book, DECT acquisition allows the simultaneous generation of multiple datasets which enable the radiologist to address varied diagnostic problems in oncologic imaging using a multiparametric approach, having clear advantages in tumor detection, lesion characterization and evaluation of treatment response.
  • This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.
  • Age of cancer incidence -- Multistage progression -- History of theories -- Progression dynamics -- Theory I -- Theory II -- Genetics of progression -- Carcinogens -- Aging -- Inheritance -- Stem cells : tissue renewal -- Stem cells : population genetics -- Cell lineage history.
  • Clinically relevant study end points in rectal cancer -- Neoadjuvant treatment in rectal cancer : do we always need radiotherapy or can we risk assess locally advanced rectal cancer better? -- Treatment dilemmas in patients with synchronous colorectal liver metastases -- Pancreatic surgery : beyond the traditional limits -- Adjuvant therapy for pancreatic cancer -- Radiotherapy of the pancreas : state of the art in 2012 -- Adenocarcinoma of the GEJ : gastric or oesophageal cancer? -- Why is there a change in patterns of GE cancer? -- Endoscopic treatment for esophageal squamous cell carcinoma -- Open or minimally invasive resection for oesophageal cancer? -- Choosing the best treatment for esophageal cancer -- Multimodal therapy of GEJ cancer : when is the definitive radiochemotherapy the treatment of choice? -- Radiotherapy of gastroesophageal junction cancer -- Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography -- Optimal surgery for gastric cancer : is more always better? -- Can adjuvant chemoratiotherapy replace extended lymph node dissection in gastric cancer? -- Predicting the response to chemotherapy in gastric adenocarcinoma : who benefits from neoadjuvant chemotherapy? -- Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients -- Adjuvant chemotherapy : an option for Asian patients only? -- Selecting the best treatment for an individual patient.
  • "This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world's leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy, and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful."--Publisher's description.
  • Endoscopic Screening and Surveillance-Indications and Standards -- Histopathology of Early Mucosal Neoplasias-Morphologic Carcinogenesis in the GI Tract -- Principles of Endoscopic Resection-Diagnostic and Curative Resection of Mucosal Neoplasias -- Endoscopic Detection and Analysis of Mucosal Neoplastic Lesions -- Enhanced Imaging and Tumor Morphology -- High-resolution Endoscopic Ultrasound -Clinical T-staging of Mucosal Neoplasms -- Squamous Cell-lined Esophagus and Hypopharynx -- Mucosal Neoplasias -- Columnar Epithelium-lined (Barrettś) Esophagus -- Mucosal Neoplasias -- Stomach-Mucosal Neoplasias -- Duodenum and Small Bowel -- Mucosal Neoplasias -- Colorectum-Mucosal Neoplasias -- Chronic Inflammatory Bowel Disease in Remission -Mucosal Neoplasias.
  • Introduction -- Roles of EBNA1 at EBV Episomes -- EBNA1-DNA Interactions -- EBNA1 Contributions to EBV-Associated Tumours -- Cellular Effects of EBNA1 -- Conclusion.
  • "ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
  • EGFR inhibitors in cancer treatment / Fortunato Ciardiello -- Mechanisms of action of EGFR inhibitors / Nicola Normanno, Maria Pergameno, Alessia Iannaccone & Antonella De Luca -- Selection of NSCLC patients to treat with EGFR inhibitors in the era of personalized medicine / Rafael Rosell, Laura Bonanno & Miquel Taron -- Clinical results with EGFR inhibitors in NSCLC and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- Clinical results with EGFR inhibitors in colorectal cancer / Erika Martinelli, Teresa Troiani, Floriana Morgillo & Fortunato Ciardiello -- EGFR-directed therapies in squamous cell carcinoma of the head and neck / Pol Specenier & Jan B. Vermorken -- Optimal use of EGFR inhibitors : challenges, new drugs and future directions / Sara De Dosso, Rodrigo Dienstmann & Josep Tabernero.
  • Electric Cell-Substrate Impedance Sensing Concept to Commercialization / Ivar Giaever and Charles R. Keese -- Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance / Havovi Chichger, Katie L. Grinnell and Elizabeth O. Harrington -- ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN) / Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason and Wen G. Jiang -- Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening / Bryan Plunger, Chang Kyoung Choi and Tim E. Sparer -- Epithelial-Mesenchymal Transition and the Use of ECIS / Jane Lane and Wen G. Jiang -- Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing / Judith Anthea Stolwijk, Stefanie Michaelis and Joachim Wegener -- Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing) / Tracey A. Martin and Wen G. Jiang -- Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS: Electric Cell-Substrate Impedance Sensing in Epithelial Research / Katalin Szaszi, Matthew Vandermeer and Yasaman Amoozadeh -- Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses / Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan and Nicholas Topley, et al. -- Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells / Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest and Wen G. Jiang -- Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents / Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang and Chun Hay Ko, et al. -- ECIS, Cellular Adhesion and Migration in Keratinocytes / David C. Bosanquet, Keith G. Harding and Wen G. Jiang -- Current and Future Applications of ECIS Models to Study Bone Metastasis / Lin Ye, Sivan M. Bokobza, Howard G. Kynaston and Wen G. Jiang.
  • Rick's Big Adventure -- All My Trials -- Fish Ate My Cancer -- Smoker's Cough -- Conference With Counsel -- Coming Through -- Here's Henry -- Why Me? -- How Do They Know What I've Got? -- Doctors and Cancer: Firewall.
  • Emerging applications of colloidal noble metals in cancer nanomedicine / Jian Zhang & Joseph R. Lakowicz -- Particle characterizations and synthesis methods / Jian Zhang & Joseph R. Lakowicz -- Diagnostics and treatments / Anna M. Sitarski, Jeremy L. Grant, Sanjeev Kumar Kandpal & Michael D. Mason -- Photothermal agents for cell theranostics / Dmitri O. Lapotko -- Drug delivery carriers / Marie-Christine Daniel -- Other applications and future directions / Ismail Ocsoy, Tao Chen & Weihong Tan -- Applications of noble metal nanoparticles in fluorescence sensing / Yi Fu -- Index.
  • Ch. 1. Quantitative radiology: applications to oncology -- Ch. 2. The intricate role of CXCR4 in cancer -- Ch. 3. Recent advances in nanoparticle-based nuclear imaging of cancers -- Ch. 4. Molecular-genetic imaging of cancer -- Ch. 5. Real-time fluorescence image-guided oncologic surgery -- Ch. 6. Cerenkov Imaging -- Ch. 7. Molecular imaging of the tumor microenvironment for precision medicine and theranostics -- Ch. 8. Tracking cellular and immune therapies in cancer -- Ch. 9. Developing MR probes for molecular imaging -- Ch. 10. Clinical translation of molecular imaging agents used in PET studies in cancer -- Index.
  • Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies. In this environment it is essential to facilitate communication and understanding of new ideas and concepts. Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research. This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.
  • Systemic Therapy for Ovarian Cancer, Current Treatment, Recent Advances, and Unmet Needs / Susana Banerjee, Michael A. Bookman, and Martin Gore -- Discovery of Novel Targets / John Farley and Michael J. Birrer -- Novel Anti-angiogenic Therapies in Ovarian Cancer / Jurjees Hasan and Gordon Jayson -- Targeting the AKT Pathway in Ovarian Cancer / Euan A. Stronach ... [et al.] -- Inhibition of the Src Oncogene : Therapeutic Potential in Ovarian Carcinoma / Liz Y. Han and Anil K. Sood -- Tumour-Specific Synthetic Lethality : Targeting BRCA Dysfunction in Ovarian Cancer / Timothy A. Yap ... [et al.] -- Targeting Inflammatory Pathways in Epithelial Ovarian Cancer / Jermaine Coward and Frances Balkwill -- Epithelial-to-Mesenchymal Transition and Cellular Membrane Receptors in Ovarian Cancer : Moving Forward in the Era of Molecularly Targeted Therapy / Lainie P. Martin, Julia J. Perkins, and Russell J. Schilder -- Epigenetic Therapies / Robert Brown, Nadine Chapman-Rothe, and Ros Glasspool -- Ovarian Cancer Immunology and Immunotherapy / Sadaf Ghaem-Maghami and Martin Gore -- Ovarian Cancer Progenitor/Stem Cells: Therapeutic Potential / Susan K. Murphy and Andrew Berchuck -- Potential for α-Folate Receptor-Targeted Treatment for Ovarian Cancer / Chau H.M. Ng and Ann L. Jackman -- New Insights into Tubulin Binders / Carles Escriu and James D. Brenton.
  • Emerging therapeutics for melanoma / Francesco M. Marincola, Paolo Ascierto & John M. Kirkwood -- Melanoma pathophysiology and drug targets / Giuseppe Palmieri, Carla Rozzo, Giusy Gentilcore & Paolo Antonio Ascierto -- Melanoma classification, diagnosis and staging / Mohammed Kashani-Sabet -- Melanoma prevention / Pamela B. Cassidy, Douglas Grossman & Sancy A. Leachman -- Surgical treatment of melanoma : from excision to sentinel node biopsy / Nicola Mozzillo & Corrado Caracò -- Adjuvant therapy in melanoma / Diwakar Davar, Ahmad A. Tarhini & John M. Kirkwood -- Immunostimulatory monoclonal antibodies for melanoma treatment / Miguel Fernandez de Sanmamed, Jose L. Perez-Gracia, Salvador Martín-Algarra & Ignacio Melero -- New signal transduction inhibitors / Keith T. Flaherty -- Melanoma vaccines in development / Ruggero Ridolfi, Laura Ridolfi, Stefania V.L. Nicoletti & Massimo Guidoboni -- Melanoma and biomarkers of immunoresponsiveness : predicting the clinical outcome of immunotherapy / Davide Bedognetti, Ena Wang, Mario Roberto Sertoli & Francesco M. Marincola -- Uveal melanoma / Paola Queirolo, Graziano Caltabiano & Francesco Spagnolo -- Management of melanoma brain metastases in the era of targeted therapies / Daniela Gonsalves Shapiro, Michael T. Shapiro & Wolfram E. Samlowski -- Which therapy for which patient? / Antoni Ribas -- Index.
  • V. 1. A-B -- v. 2. C -- v. 3. D-G -- v. 4. H-L -- v. 5. M-O -- v. 6. P-R -- v. 7. S-Z.
  • SECTION I: SCIENTIFIC FOUNDATIONS OF RADIATION ONCOLOGY -- Part A: Radiobiology -- Part B: Physics -- SECTION II: Techniques and Modalities -- SECTION III: DISEASE SITES -- Part A: Central Nervous System Tumors Overview -- Part B: Head and Neck Tumors Overview -- Part C: Thoracic Neoplams Overview -- Part D: Gastrointestinal Tumors Overview -- Part E: Genitourinary Tumors Overview -- Part F: Gynecologic Tumors Overview -- Part G: Breast Cancer Overview -- Part H: Sarcoma and Benign Disease -- Part I: Childhood Cancers Overview -- Part J: Lymphoma & Hematologic Malignancies Overview.
  • Endocrine neoplasia 2010
    Also available: Print – 2010
    Part. I Thyroid.-- Biology of thyroid oncogenesis / Insoo Suh, Electron Kebebew.-- Evaliation of the thyroid nodule / Dina M. Elaraj.-- Differentiated thyroid cancers of follicular cell origin / Linwah Yip, Sally E. Carty.-- Sporadic medullary thyroid cancer / Adrian Harvey, Janice L. Pasieka.-- Anaplastic thyroid cancer / Alan P.B. Dackiw.-- Part II. Parathyroid.-- Primary hyperparathyroidism / Kaitlyn J. Kelly, Herbert Chen, Rebecca S. Sippel.-- Parathyromatosis and parathyroid cancer / Wen T. Shen.-- Part III. Incidentaloma / Jacob Malem, Insoo Suh, Quan-Yang Duh.-- Pheochromocytoma and paraganglioma / Goswin Y. Meyer-Rochow, Stan B. Sidhu.-- Functional cortical neoplasms / Ali Zarrinpar, Michael W. Yeh.-- Adrenocortical carcinoma / Patsy S.H. Soon, Stan B. Sidhu.-- Part IV. Pnacreatic neuroendocrine tumors.-- Gastrinoma / Anthony J. Chambers, Janice L. Pasieka.-- Insulinoma / Kimberly Vanderveen, Clive Grant.-- Rare neuroendocrine tumors of the pancreas / Shih-Ping Cheng, Gerard M. Doherty.-- Part V. Multiple endocrine neoplasia.-- Menin gene / Hsin-Chieh Jennifer Shen, Steven K. Libutti.-- Multiple endocrine neoplasia type I: clinical manifestations and management / Anathea C. Powell, Steven K. Libutti.-- RET protooncogene / Amber L. Traugott, Jeffrey F. Moley.-- Multiple endocrine neoplasia type 2: clinical manifestations and management / Amber L. Traugott, Jeffrey F. Moely.
  • Multiple endocrine neoplasia type 1 / Agarwal, S.K. -- Multiple endocrine neoplasia type 2 / Lodish, M. -- Von Hippel-Lindau syndrome / Chou, A. ... [et al.] -- Carney complex -- Espiard, S., Bertherat, J. -- Multiple endocrine neoplasia type 4 / Lee, M., Pellegata, N.S. -- Novel hereditary forms of pheochromocytomas and paragangliomas / Dahia, P.L.M. -- Carney triad / Carney, J.A. -- Genetics of pituitary adenomas / Gadelha, M.R. ... [et al.] -- Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer / Bauer, A.J. -- Genetic defects associated with familial and sporadic hyperparathyroidism / Hendy, G.N., Cole, D.E.C. -- Endocrine tumors associated with neurofibromatosis type 1, Peutz-Jeghers syndrome, and other familial neoplasia syndromes / Kalkan, E., Waguespack, S.G.
  • Hypopituitarism following radiotherapy revisited / Darzy, K.H., Shalet, S.M. -- Alterations in pubertal timing following therapy for childhood malignancies / Armstrong, G.T., Chow, E.J., Sklar, C.A. -- Obesity during and after treatment for childhood cancer / Reilly, J.J. -- Metabolic disorders / Gregory, J.W. -- Bone and bone turnover / Crofton, P.M. -- Male fertility and strategies for fertility preservation following childhood cancer treatment / Mitchell, R.T. ... [et al.] -- Fertility in female childhood cancer survivors / De Bruin, M.L. ... [et al.] -- Long-term follow-up of survivors of childhood cancer / Edgar, A.B. ... [et al.].
  • Also available: Print – 2008
    Current status of the prevention and early diagnosis of endometrial adenocarcinoma -- The value of endometrial cytology -- Techniques of endometrial cytology -- Techniques of endometrial histopathology -- New techniques for the diagnosis of endometrial pathology -- Cytology of the normal endometrium - cycling and postmenopausal -- Benign endometrial lesions -- Cytopathology of endometrial hyperplasias -- Cytopathology of endometrial adenocarcinoma -- Cytopathology of the non-epithelial malignant tumors of the uterine corpus.
  • Barrett's esophagus : screening, diagnosis, and management / Glenn M. Eisen -- Endoscopic screening for squamous cell carcinoma of the esophagus / Brian C. Jacobson -- Image enhancement endoscopy / Stephan M. Wildi and Michael B. Wallace -- Staging of esophageal cancer / Jason Vollweiler and Gregory Zuccaro, Jr. -- Endoscopic therapy for early esophageal cancer and premalignant lesions in Barrett's esophagus / Granapathy A. Prasad and Kenneth K. Wang -- Endoscopic therapy for advanced esophageal cancer / Sanjay Jagannath and Marcia I. Canto -- Radiological imaging of the upper gastrointestinal tract / Marc S. Levine -- Esophageal cancer therapy : surgery, radiation, and chemotherapy / John M. Holland and Christopher A. Canning -- Premalignant lesions of the stomach / Omid A. Shaye and Andrew Ippoliti -- Gastric polyps / George A. Makar and Gregory G. Ginsberg -- Endoscopic ultrasound for staging gastric cancer / Gregory Olds and Amitabh Chak -- Endoscopic treatment for gastric cancer / Takuji Gotoda and Roy M. Soetikno -- Diagnosis and management of gastrointestinal lymphoma / John G. Kuldau, Peter R. Holman, and Thomas J. Savides -- Gastrointestinal stromal tumors / Raquel E. Davila -- Carcinoid tumors / Wilscott E. Naugler and Gordon C. Hunt -- Medical and surgical therapy for gastric cancer / Diane Hershock -- Colorectal cancer screening / Jason A. Dominitz and William M. Grady -- Polyposis and familial cancer syndromes / Fernando S. Velayos, Madhulika G. Varma, and Jonathan P. Terdiman -- Endoscopic colon surveillance : post-polypectomy, post-colorectal cancer resection, and inflammatory bowel disease / Douglas B. Nelson and Mandeep S. Sawhney -- Endoscopic ultrasound for staging rectal and anal cancer / Deepak V. Gopal -- Endoscopic therapy of colorectal carcinoma / Vaman Jakribettuu and Yang K. Chen -- Radiological imaging of the lower gastrointestinal tract / Steven E. Rubesin -- Current status of colorectal cancer therapy / John Strother ... [et al.] -- Cystic neoplasms of the pancreas / William R. Brugge -- Diagnosis and evaluation of pancreatic ductal adenocarcinoma / Kenneth H. Yu and Nuzhat A. Ahmad -- Adenocarcinoma of the pancreas : endoscopic palliation / Georgios I. Papachristou, Kevin McGrath, and Adam Slivka -- Pancreatic neuroendocrine tumors / Erik-Jan Wamsteker and James M. Scheiman -- Endoscopic diagnosis and management of cholangiocarcinoma / Vanessa M. Shami and Irving Waxman -- Ampullary neoplasia / Ian D. Norton -- Magnetic resonance imaging of neoplasms of the pancreatobiliary system / Evan S. Siegelman and Wendy C. Hsu -- Medical and surgical therapy of pancreatic cancer / Weijing Sun, Jon Morris, and Jeffrey Drebin -- Endoscopic ultrasound for thoracic disease / Timothy Woodward, Massimo Raimondo, and Michael B. Wallace.
  • Merging of endourology and oncology: endourooncology / A. El-Hakim, B.R. Lee, and A.D. Smith -- Surgical robots and three-dimensional displays for computer-aided surgery / T. Dohi -- Robot-assisted (Da Vinci) urologic surgery: an emerging frontier / A.K. Hemal and M. Menon -- Robotic surgery assisted by the ZEUS system / M. Eto and S. Naito -- Telesurgery: remote monitoring and assistance laparoscopy / T. Inagaki, S.B. Bhayani, and L.R. Kavoussi -- Remote percutaneous renal access using a telesurgical robotic system / B. Challacombe, L. Kavoussi, and D. Stoianovici -- Radiofrequency ablation for percutaneous treatment of malignant renal tumors / S. Kanazawa, T. Iguchi, K. Yasui, H. Mimura, T. Tsushima, and H. Kumon -- High-intensity focused ultrasound for noninvasive renal tumor thermoablation / A. Häckr, M.S. Michel, and K.U. Köhrmann -- High-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer / T. Uchida, H. Ohkusa, H. Yamashita, and Y. Nagata -- Renal cryoablation / K. Nakagawa and M. Murai -- Prostate cryoablation / B.J. Donnelly and J.C. Rewcastle -- Tumor control outcome and tolerance of permanent interstitial implanation for patients with clinically localized prostate cancer / Y. Nasu, F. Abarzua, and H. Kumon.
  • Energy balance and cancer v. 1-, 2011-
  • The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
  • The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and fat metabolism. This volume on Energy Balance in Hematologic Malignancies will provide an important volume in this series and a basis for better understanding etiology, mechanisms, therapeutics implications and experimental approaches. This volume of energy balance and cancer will focus on the relation of obesity to hematologic malignancies, the epidemiology, potential mechanisms, and thereapeutic considerations including effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance.
  • Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
  • The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.
  • Part 1. General Principles -- Introduction / Deodutta Roy and M. Tevfik Dorak -- Gene-Environment Interactions, Phenotypic Changes, and Human Health / Rosemarie G. Ramos and Kenneth Olden -- Statistics for Testing Gene-Environment Interaction / Momiao Xiong and Xuesen Wu -- Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers / Richard J.Q. McNally -- Discovering Gene-Gene and Gene-Environment Causal Interactions Using Bioinformatics Approaches / Changwon Yoo -- Gene Environment Interactions and Vascular Lesions / Quentin Felty -- Epigenetic Changes in Cancer: Role of Environment / Zdenko Herceg and Paolo Boffetta -- Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility / Alok Deoraj and Deodutta Roy -- Part 2. Environment and Specific Types of Cancer -- Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors / Brian Kunkle, David Sandberg, Prasanna Jayakar, Quentin Felty and Deodutta Roy -- Genetic Polymorphisms Predisposing Individuals to Breast Cancer Via Gene-Environment Interaction / Keun-Young Yoo, Sue K. Park and Aesun Shin -- Environment, Genetic Immunology and Childhood Cancer / Esma Ucisik-Akkaya and M. Tevfik Dorak -- Exposure to Environmental Mutagens: APC and Colorectal Carcinogenesis / Aruna S. Jaiswal, Melissa L. Armas, Shahnjayla K. Connors, Harekrushna Panda and Satya Narayan -- Gene-Environmental Interactions and Susceptibility to Liver Cancer / John B. Colerangle -- Genetic Epidemiology of Mismatch Repair Deficiency in Ovarian Cancer / Tuya Pal, Jenny Permuth Wey and Thomas A. Sellers -- Part 3. Case Studies -- Betel Nut and Susceptibility to Cancer / Rajesh N. Sharan and Yashmin Choudhury -- Birth Weight and Cancer Associations / Nadia Barahmani and M. Fatih Okcu -- Iron Excess and Cancer / Charronne F. Davis and M. Tevfik Dorak.
  • Also available: Print – 2014
    Enzinger and Weiss's Soft Tissue Tumors is a medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
  • Benign melanocytic proliferations -- Essential criteria for diagnosing melanoma -- Histologic mimics of malignant melanoma -- Epidermal neoplasms -- Pilosebaceous neoplasms -- Tumors with eccrine differentiation -- Merkel cell carcinoma.
  • Also available: Print – 2013
  • The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chimeric, leukemia-specific transcription factors. This book first presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
  • Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.
  • Systems and Network Biology to Investigate Epigenetic De-regulatory Mechanisms of MicroRNAs in Pancreatic Cancer / Irfana Muqbil, Fazlul H. Sarkar, Ramzi M. Mohammad -- Role of MicroRNAs in Cancer Epigenetics / Kishore B. Challagundla, Petra Wise, Muller Fabbri -- Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs / Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong -- Epigenetics and MicroRNAs in Renal Cancer / Shahana Majid ... [et al.] -- Epigenetic Regulation of MicroRNA in Colon Cancer / Qiong Zhang, Mukesh Verma, Sharad Khare -- Epigenetic Regulation of miRNAs in Breast Cancer Formation and Progression / Zhiqian Zhang ... [et al.] -- Epigenetic Variations of Stem Cell Markers in Cancer / Sripathi M. Sureban, Dongfeng Qu, Courtney W. Houchen -- Recent Updates on Epigenetic Biomarkers for Prostate Cancer / Karen Chiam, Tanya Kate Day, Tina Bianco-Miotto -- Epigenetics and Racial Disparities in Prostate Cancer / Benjamin A. Rybicki -- Epigenetic Signatures of Breast Cancer Genes / Shrikant Anant, Animesh Dhar, Satish Ramalingam -- Exploiting Epigenetic Modifiers to Circumvent Melanoma Dual Resistance to TCR-Engineered Immunotherapy- and BRAF V⁶⁰⁰E-Kinase Inhibitor / Ali R. Jazirehi CLS, -- The Role of Epigenetics in Radiation Therapy and the DNA Damage Response / Steven P. Zielske -- Plant Polyphenols as Epigenetic Modulators of Glutathione S-Transferase P1 Activity / Vijay S. Thakur, Sanjay Gupta -- Epigenetic Regulations of mRNAs and miRNAs by Nutraceuticals / Yiwei Li ... [et al.] -- Towards Curative Cancer Therapy with Maspin: A Unique Window of Opportunity to Target Cancer Dormancy / Alexander Kaplun, M. Margarida Bernardo, Sijana Dzinic.
  • Esophageal cancer causes an estimated 386,000 deaths worldwide and is the sixth most common cause of death for men. The background characteristics of esophageal cancer treatment are markedly different between Asian and Western countries, however. In tumor histology, squamous cell carcinoma associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barrett?s metaplasia is markedly prevalent in the West. In Asia, especially in Japan, the key persons who play important roles in the management of esophageal cancer patients are surgeons; in the West those roles are filled by medical and radiation oncologists as well as surgeons. The philosophy of surgeons regarding cancer surgery varies from locoregional to local tumor control, particularly in focusing on lymph node dissection. Physicians? approach to surgical adjuvant therapy differs, therefore, between Asia and the West. Considering these East?West differences in esophageal cancer treatment, the currently available results of Western evidence should not be considered directly applicable to esophageal cancer in Asia. In this book, the authors discuss the knowledge base in Japan in terms of treatment of esophageal squamous cell carcinoma. Since this volume contains a wide spectrum of current information and addresses topics surrounding the treatment of patients with esophageal squamous cell carcinoma, it is highly relevant to Asian physicians and researchers as well as to their counterparts in the West.
  • The Normal Breast -- Specimen Processing -- Fibrocystic Change and Duct Ectasia -- Adenosis -- Intraductal Proliferative Lesions -- Intraductal Papillary Neoplasms -- Lobular Intraepithelial Neoplasia (LIN) -- Infiltrating Ductal Carcinoma (NOS Type) -- Invasive Lobular Carcinoma (ILC) -- Special Types of Breast Carcinomas -- Biphasic Tumors -- Disease of the Nipple -- Male Breast Lesions -- Mesenchymal Lesions/Tumors -- Myoepithelial Lesions/Neoplasms -- Miscellaneous Lesions -- Cytopathology of Benign and Malignant Lesions (Selected Topics) -- Immunohistochemistry (Selected Topics).
  • Also available: Print – 2005
  • Also available: Print – 2008
  • Part 1. Cover Stories -- Martine Piccart: Medic and Musician ... / Helen Saul, p. 5-11 -- Gordon McVie: Making Waves / Helen Saul, p. 13-20 -- Agnes Glaus: Softly Softly / Helen Saul, p. 21-27 -- Mariano Barbacid: The Homecoming / Helen Saul, p. 29-36 -- Liisa Elovainio: Tough on Tobacco / Helen Saul, p. 37-45 -- Franco Cavalli: Rebel with (Several) Rauses / Helen Saul, p. 47-54 -- Françoise Meunier: Chameleon Chief / Helen Saul, p. 55-63 -- Jean-Pierre Armand: Sifting Sand / Helen Saul, p. 65-73 -- Silvia Marsoni: The Go-Between / Helen Saul, p. 75-85 -- Harry Bartelink: Putting Europe First / Helen Saul, p. 87-94 -- Nora Kearney: Shaking Up the Big House / Jim McGuigan, p. 95-104 -- Paris and Helen Kosmidis: A Legend in their Own Time / Jim McGuigan, p. 105-115 -- Jacek Jassem: Reaching out From Gdansk / Marc Beishon, p. 117-127 -- Part 2. Masterpieces -- Interview with Umberto Veronesi / Maurice Schneider, p. 131-135 -- Maurice Tubiana: The Fighting Spirit Behind Cancerology / Maurice Schneider and Raphaël Brenner, p. 137-140 -- Michael Baum: Shooting Sacred Cows / Helen Saul, p. 141-149 -- Hans-Jörg Senn: Championing Consensus / Anna Wagstaff, p. 151-158 -- Gianni Bonnadona: Fighting for Every Life / Anna Wagstaff, p. 159-165.
  • This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.
  • Historical Introduction -- Descriptive Biostatistics -- Inferential Biostatistics (I): Estimating Values of Biomedical Magnitudes -- Inferential Biostatistics (II): Estimating Biomedical Behaviors -- Equations: Formulating Biomedical Laws and Biomedical Magnitudes -- Systems of Equations: The Explanation of Biomedical Phenomena (I). Basic Questions -- Systems of Equations: The Explanation of Biomedical Phenomena (II). Dynamic Interdependencies -- Optimal Control Theory: From Knowledge to Control (I). Basic Concepts -- Optimal Control Theory: From Knowledge to Control (II). Biomedical Applications -- Game Theory.
  • pt. I. Introduction -- pt. II. Combined modularized therapies for metastic tumors : pointing to central problems of communication among 'systems participators' in tumors -- pt. III. Social engineering : biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions -- pt. IV. The tumors' normativity : reconstructing and operationalizing starting points for an evolution theory -- pt. V. Evolution theory -- pt. VI. From genome- or organ-centric to rationalization-centric systematization of tumors -- pt. VII. Reconstruction of tumor-immanent normative functions, structures and decision maxims (hubs) -- pt. VIII. The tool of rationalizations constituting tumor-associated normative notions : the non-genomic counterpart of the tumor genome and therefore, an important therapeutic target for diversifying palliative care -- pt. IX. Novel clinical and pharmaceutical technology for bioengineering tumor response -- pt. X. Objectifying the systems objects' subjectivity in biological systems : a novel reification of the scientific picture about the 'objective' world.
  • Although it is well established that the worldwide pandemic of overweight and obesity has profound effects on promoting cancer, it is now recognized that alternative aspects of energy balance, namely physical activity and exercise have significant beneficial effects on all aspects of cancer across the spectrum from prevention through treatment and extending through survivorship. While the effect of physical activity and exercise on cancer may be partially mediated through obesity control, it is clear that considerable research is required and is ongoing at both the molecular and clinical levels to better understand the associated mechanisms and to develop optimal exercise strategies. This volume presents the effects of exercise on biological pathways in tumor growth, state of the art exercise strategies and cutting edge research focused on different cancers and patient groups. This important text will provide a basis for ongoing research, experimental approaches and application of evidence based practices to clinical care for patients with cancer.
  • T cell therapy: state-of-the-art -- Extending the use of adoptive T cell immunotherapy for infections and cancer -- Non-T cell therapeutic approaches -- B lymphocytes in cancer immunology -- Monoclonal antibody therapy for cancer -- Natural killer cells for cancer immunotherapy -- Dendritic cell-based cancer vaccines: practical considerations -- Mesenchymal stromal cells: an emerging cell-based pharmaceutical -- T cell therapeutic approaches -- Tumor-specific mutations as targets for cancer immunotherapy -- Counteracting subversion of MHC class II antigen presentation by tumors -- Mechanisms and implications of immunodominance in CD8⁺ T-cell responses -- T regulatory cells and cancer immunotherapy -- Negative regulators in cancer immunology and immunotherapy -- Genetically engineered antigen specificity in T cells for adoptive immunotherapy -- Non-cellular aspects of cancer immunotherapy -- Cytokine immunotherapy -- Transcriptional modulation using histone deacetylase inhibitors for cancer immunotherapy -- Combining cancer vaccines with conventional therapies -- Combining oncolytic viruses with cancer immunotherapy -- Radiation therapy and cancer treatment: from the basics to combination therapies that ignite immunity -- Assessing immunotherapy through cellular and molecular imaging -- Transplantation -- Allogeneic and autologous transplantation therapy of cancer: converging themes.
  • The primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well established and usually results in local control, treating metastatic disease is a much more daunting task. At diagnosis, few patients present with clinically detectable metastatic lesions regardless of the clinical prognostic factor. Clinical trials assessing potential therapeutic agents are important in order to define the best specific treatment for a particular patient, which are the basis for patient-oriented research that eventually lead to personalized medicine.This volume aims to comprehensively present the latest research and information about metastasis. Understanding the mechanisms underlying the metastatic phenomenon could have vast implications for the large number of patients who are at a high risk for the development of metastasis.
  • Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination.
  • Advances in genomic technologies have allowed investigators to survey diverse molecular properties of cancer cells including DNA copy number alterations, RNA transcript abundance, and protein-DNA binding events. While each data type offers a unique snapshot of the tumor cell, an integrated analysis of two or more complementary data types can reveal much more than the sum of its parts. In this dissertation, I describe new integrative genomic methodologies and novel biologic insights gleaned from their application. In one such analysis of 52 breast cancer cell lines, we identify genomic alterations and gene-expression profiles that largely resemble those identified in primary breast tumors, therefore defining relevant tumor models of breast cancer subtypes. Additionally, we identify 80 high-level DNA amplifications and 13 multi-copy deletions, harboring known and novel cancer genes, thereby providing a rich resource for new breast cancer gene discovery and characterization. In an integrative analysis of colorectal cancers, we unveil a region of amplification highly specific to colorectal-derived tumors. We identify and characterize caudal type homeobox transcription factor 2 (CDX2), a master regulator of intestinal cell survival and differentiation, as the target gene of this amplification, and show a CDX2 amplification-specific dependency for tumor cell survival, proliferation, and anchorage-independent growth. Moreover, by integrating protein-DNA binding and gene expression data, we uncover a novel relationship between CDX2 and Wnt/[beta]-catenin signaling. Taken together, these data show that for a subset of colorectal-derived tumors, cell survival and proliferation are dependent on the abnormal amplification and overexpression of CDX2, thereby characterizing CDX2 as a novel lineage-survival oncogene in colorectal cancer. In the last portion of the dissertation, I reflect on how the rapidly growing knowledgebase of genetic associations with disease and drug response will help usher in a new era of personalized medicine. To help prepare for a future that includes an array of available genomic laboratory tests, I discuss the necessity to reform medical school curricula to educate students about the interpretation, limitations, and impact of genomic testing in clinical medicine. I describe the challenges and considerations relevant to the development of a novel educational curriculum that includes personal genomic testing.
  • Extranodal lymphomas 2011
    2011 ClinicalKey
    Introduction to extranodal lymphomas / Judith A. Ferry -- Lymphomas of the nervous system and the meninges / Judith A. Ferry -- Lymphomas of the head and neck / Judith A. Ferry -- Lymphomas of the thorax / Judith A. Ferry -- Lymphomas of the esophagus, gastrointestinal tract, hepatobiliary tract, and pancreas / Judith A. Ferry -- Lymphomas of the spleen / Aliyah R. Sohani and Lawrence R. Zukerberg -- Adrenal lymphomas / Judith A. Ferry -- Lymphomas of the urinary tract / Judith A. Ferry -- Lymphomas of the male genital tract / Judith A. Ferry -- Lymphomas of the female genital tract / Judith A. Ferry -- Cutaneous lymphomas / Lyn M. Duncan, Johanna l. Baran, and Judith A. Ferry -- Lymphomas of bone / Judith A. Ferry -- Lymphomas of the bone marrow / Robert P. Hasserjian -- Intravascular lymphomas / Judith A. Ferry.
  • Eyelid tumors are commonly encountered by oculoplastic as well as plastic surgeons. The challenge of managing these cases lies not only in performing the surgery in a precise manner in small area, but also in ensuring a visually-appealing cosmetic outcome. This is an innovative and concise portable handbook that guides the surgeons on how to approach and manage these cases in a step-by-step manner. Each chapter of this practical guidebook has outstanding illustrations drawn in full color clearly showing each incision line, flap management, suture placement and its technique, and the expected cosmetic outcome. When a lid tumor is excised, there is a tissue defect that needs to be corrected. Ophthalmologists and plastic surgeons will find this work an excellent reference material to solve the jigsaw puzzle of tissue defects in and around the periorbital region. Importantly, they can quickly refer to the images just before starting a procedure. The author has first explained the anatomical aspects and anesthetic techniques for eyelid surgery, followed by review of the benign and malignant tumors, finally describing the flap creation and reconstruction techniques that are currently used in various lid tumors in an organized fashion.
  • FDG PET/CT has rapidly emerged as an invaluable combined imaging modality that can identify tumors on the basis of not only anatomical alterations but also metabolic activity, thus allowing the detection of lesions that would otherwise be too small to distinguish. This book, comprising a collection of images from oncology cases, is organized according to the role of FDG PET/CT in the evaluation and management of oncology patients, and only secondarily by organ or tumor entity. In this way, it reflects the issues that clinicians actually address in their daily practice, namely: identification of an unknown or unsuspected primary; determination of the extent of disease; evaluation of response to therapy; and surveillance after response, i.e., detection of recurrent disease. In total, 100 cases involving different primary tumors are presented to illustrate findings in these different circumstances. FDG PET/CT in Clinical Oncology will be of great value to all newcomers to this field, whether medical students, radiology, nuclear medicine, or oncology fellows, or practicing physicians.
  • This book provides a detailed update on all aspects of fine-needle aspiration cytology of breast lesions. It will serve readers as an up-to-date reference and atlas on both new entities in breast pathology, including borderline lesions such as flat epithelial atypia, and the classic benign and malignant lesions. Throughout, emphasis is placed on the characteristic diagnostic features as well as the common pitfalls faced by cytologists. As cytologic features can be highly variable, corresponding cytology and histology images are displayed together, enabling readers to gain a good understanding of the morphologic features of various lesions. Core-needle biopsy and fine-needle aspiration cytology are compared in depth, with attention to their relative strengths and weaknesses and indications. In addition, the impact of molecular classification of breast cancers on cytologic diagnosis is explored, and the use of molecular techniques in diagnostic cytology is discussed.
  • Epidemiology of bone tumours -- Radiological investigation of bone tumours -- Morphological diagnosis of bone tumours -- Cytology of normal constituents in bone aspirates and of reactive changes -- Cytological features of bone tumours in FNA smears I : osteogenic tumours -- Cytological features of bone tumours in FNA smears II : cartilaginous tumours -- Cytological features of bone tumours in FNA smears III : Ewing family tumours -- Cytological features of bone tumours in FNA smears IV : notochordal tumours -- Cytological features of bone tumours in FNA smears V : giant-cell lesions -- Rare targets for FNAC and diagnostic problems with benign tumours/lesions with variable numbers of osteoclast-like giant cells -- Lymphohaematopoetic and histiocytic tumours -- Inflammatory lesions -- Bone metastases -- Fine needle aspiration as the first diagnostic modality for spinal and sacral lesions.
  • This volume presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters cover the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging, including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.
  • Also available: Print – 2009
    Historical aspects -- Techniques -- Flow cytometry in fine-needle aspiration diagnosis of lymphomas / in collaboration with Anna Porwit-MacDonald -- B cell neoplasms -- T cell neoplasms -- Hodgkin lymphoma -- Lymphadenopathy in HIV-infected patients -- Histiocytic and dendritic neoplasms -- Extranodal lymphomas -- Lymphoma look-alike.
  • History, indications, technique and limitations / Singh, A.D. ... [et al.] -- Cytological preparation / Brainard, J.A., Biscotti, C.V. -- Uveal metastases / Biscotti, C.V., Singh, A.D. -- Uveal lymphoma / Chute, D.J., Biscotti, C.V., Singh, A.D. -- Uveal melanoma : diagnostic features / Biscotti, C.V., Singh, A.D. -- Uveal melanoma : prognostication / Turell, M.E. ... [et al.] -- Vitreous biopsy : specimen preparation and interpretation / Coupland, S.E. -- Fine needle aspiration biopsy of retinal tumors / Ali, M.J. ... [et al.] -- Fine needle aspiration cytology in orbital tumors / Seregard, S., Tani, E. -- Future of ophthalmic fine needle aspiration biopsy / Singh, A.D., Dolan, B., Biscotti , C.V.
  • Also available: Print – 2006
  • Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method.
  • Cancer survivors -- The medical and psychological concerns of cancer survivors after treatment -- Delivering cancer survivorship care -- Providers of survivorship care: their supply and education and training -- Employment, insurance, and economic issues -- Research.
  • Also available: Print – 2006
    The origin and development of neural crest-derived melanocytes / Debra L. Silver and William J. Pavan -- MITF : a matter of life and death for the developing melanocytes / Heinz Arnheiter ... [et al.] -- MITF : critical regulator of the melanocyte lineage / Erez Feige, Laura L. Poling, and David E. Fisher -- Melanocytes and the transcription factor Sox10 / Michael Wegner -- Human cutaneous pigmentation : a collaborative act in the skin, directed by paracrine, autocrine, and endocrine factors and the environment / Zalfa A. Abdel-Malek and Ana Luisa Kadekaro -- Melanocyte distribution and function in human skin : effects of ultraviolet radiation / Yuji Yamaguchi and Vincent J. Hearing -- Altered signal transduction in melanoma / Pablo López Bergami, Anindita Bhoumik, and Ze'ev Ronai -- BRN2 in melanocytic cell development, differentiation, and transformation / Anthony L. Cook ... [et al.] -- The dynamic roles of cell-surface receptors in melanoma development / Dong Fang and Meenhard Herlyn -- Familial melanoma genes, melanocyte immortalization, and melanoma initiation / Dorothy C. Bennett -- Genetic progression from melanocyte to malignant melanoma / Boris C. Bastian -- The multiple roles of the oncogenic protein SKI in human malignant melanoma / Dahu Chen ... [et al.] -- RB/E2F regulation and dual activity in the melanocytic system / Ruth Halaban -- Melanoma development and pigment cell transformation / Claudia Wellbrock -- The biology and genetics of melanoma / Norman E. Sharpless and Lynda Chin -- The biology of xeroderma pigmentosum : insights into the role of ultraviolet light in the development of melanoma / James E. Cleaver -- Divergent pathways to cutaneous melanoma / David C. Whiteman and Adéle C. Green -- Pigmentation, DNA repair, and candidate genes : the risk of cutaneous malignant melanoma in a mediterranean population / Maria Teresa Landi -- Low-penetrance genotypes, pigmentation phenotypes, and melanoma etiology / Peter A. Kanetsky and Timothy R. Rebbeck -- The biology of melanoma progression : from melanocyte to metastatic seeds / A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. -- Optical imaging analysis of atypical nevi and melanoma / Amanda Pfaff Smith and Dorothea Becker -- Proteomics analysis of melanoma cell lines and cultured melanocytes / Katheryn A. Resing and Natalie G. Ahn -- Paradigm of metastasis for malignant melanoma / Stanley P.L. Leong -- Repair of UV-induced DNA damage and melanoma risk / Qingyi Wei -- High risk factors for melanoma metastasis / Neil A. Accortt and Seng-jaw Soong -- Role of melanoma inhibitory activity in early development of malignant melanoma / Anja-Katrin Bosserhoff -- Role and regulation of PAR-1 in melanoma progression / Carmen Tellez and Menashe Bar-Eli -- Molecular mechanisms of melanoma metastasis / Mohammed Kashani-Sabet -- Overview of tumor progression in melanoma / David E. Elder -- The plasticity of melanoma cells and associated clinical implications / Mary J. C. Hendrix ... [et al.] -- The clinical use of molecular markers as predictors of disease outcome and response to therapy in malignant melanoma / Steve R. Martinez, Hiroya Takeuchi, Dave S.B. Hoon -- The role of DCT/TYRP2 in resistance of melanoma cells to drugs and radiation / Brian J. Pak and Yaacov Ben-David -- How melanoma cells evade chemotherapy : role of transporter-dependent and -independent resistance mechanisms / Kevin G. Chen and Michael M. Gottesman -- Apoptosis in melanoma: approaches to therapy / Heicke Röckmann and Dirk Schadendorf -- Role of melanoma-associated antigens / Rishab K. Gupta, Ana M. McElrath-Garza, and Donald L. Morton -- Host responses to melanoma : implications for immunotherapy / Julian A. Kim and Ernest Borden -- Future perspectives / Vincent J. Hearing and Stanley P.L. Leong.
  • "The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away-in a scientifically accessible manner-from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions)"--Back cover.
  • Intraoperative evaluation of colorectal specimens containing cancer -- Intraoperative evaluation for extracolonic disease in colon cancer patients -- Metastases and mimics of colorectal carcinoma -- Non-epithelial tumors of the colorectum -- Frozen section assessment of the colorectum in the pediatric population -- Frozen section evaluation of the appendix -- Frozen section evaluation of anal disease.
  • Introduction -- Bone/Osteoid Producing Lesions -- Cartilage-Producing Lesions -- Fibrous and Fibrohistiocytic Lesions -- Giant Cell-Rich Lesions -- Small/Round Cell Lesions -- Cystic and Vascular Lesions -- Epithelial Lesions.
  • 1. Sentinel Lymph Nodes -- 2. Assessment of the Surgical Margins -- 3. Diagnostic Evaluation of a Breast Mass -- 4. Handling of Specimens with a Nonpalpable Lesion -- 5. Core Needle Biopsies -- 6. Regulatory Requirements for Breast Specimens.
  • General considerations -- Nasal cavity and paranasal sinuses -- Salivary glands -- Oral cavity, pharynx, and larynx -- Neck -- Head and neck presentations of intracranial lesions.
  • Ch. 1. Introduction -- Ch. 2. Potential to reduce the cancer burden through cancer prevention and early detection -- Ch. 3. Lifestyle behaviors contributing to the burden of cancer -- Ch. 4. Modifying health risk behaviors -- Ch. 5. Potential of screening to reduce the burden of cancer -- Ch. 6. Improving participation in cancer screening programs -- Ch. 7. Adopting new technology in the face of uncertain science: the case of screening for lung cancer -- Ch. 8. Professional education and training -- Ch. 9. Federal programs that support cancer prevention and early detection -- Ch. 10. Research trends and opportunities -- Ch. 11. Findings, policy implications, and recommendations.
  • This book presents a comprehensive overview of current state-of-the-art clinical physiological imaging of brain tumors.? It focuses on the clinical applications of various modalities as they relate to brain tumor imaging, including techniques such as blood oxygen level dependent functional magnetic resonance imaging, diffusion tensor imaging, magnetic source imaging/magnetoencephalography, magnetic resonance perfusion imaging, magnetic resonance spectroscopic imaging, amide proton transfer imaging, high angular resolution diffusion imaging, sodium imaging, and molecular imaging. Featuring contributions from renowned experts in functional imaging, this book examines the diagnosis and characterization of brain tumors, details the application of functional imaging to treatment planning and monitoring of therapeutic intervention, and explores future directions in physiologic brain tumor imaging. Intended for neuro-oncologists, neurosurgeons, neuroradiologists, residents, and medical students, Functional Brain Tumor Imaging is a unique resource that serves to advance patient care and research in this rapidly developing field.
  • Part I. Clinical and therapeutic approach to functional oncological imaging -- part II. Imaging of cancer hallmarks -- part III. Functional imaging techniques in clinical use -- part IV. Molecular imaging techniques in clinical use and in research.
  • Tumors of the CNS and Spinal Cord -- Functional Magnetic Resonance Techniques in CNS Tumors -- MR Imaging Evaluation of Posttreatment Changes in Brain Neoplasms -- Metastasis and Other Tumors of the CNS -- Spinal Cord Tumors: Anatomic and Advanced Imaging -- Head and Neck Cancer -- Chest Malignancies -- Lung Cancer: PET, Perfusion CT, and Functional MR Imaging -- Functional Imaging of Malignant Pleural Mesothelioma and other Pleural and Chest Wall Lesions -- Functional Imaging of Malignant Pleural Mesothelioma and other Pleural and Chest Wall Lesions -- Thymomas and Other Thymic Primary Malignancies of the Chest -- Functional Imaging in Cardiac Tumors -- Women's Cancers -- Breast Cancer -- PET-CT of Gynecological Malignancies and Ovarian Cancer -- Functional MRI of Uterine (Endometrial and Cervical) Cancer -- Functional Imaging of Ovarian Cancer and Peritoneal Carcinomatosis -- Malignancies of the Gastrointestinal System -- Esophagus, Stomach, and Small Bowel Malignancies -- Colorectal Cancer -- Hepatobiliary and Pancreatic Malignancies -- Overview of Functional Imaging Techniques for Liver Malignancies in Current Clinical Practice or in a Very Near Future -- Hepatocellular Carcinoma -- Role of Functional MRI in the Management of Liver Metastases -- Other Malignant Lesions of the Liver -- Functional Imaging of Gallbladder and Biliary Malignancies -- Splenic Lesions -- Genitourinary Tract Tumors -- Functional Imaging of Renal Cell Carcinoma -- Functional CT and MRI of the Urinary System and Adrenal Glands -- Prostate Cancer -- Scrotum -- Functional Imaging of Tumors of the Mesenterium and Retroperitoneum -- Malignancies of the Endocrine System -- Functional Oncological Imaging of the Endocrine System -- Hematological Malignancies -- Functional Imaging in Clinical Use for the Assessment of Lymph Nodes in Oncological Patients -- Functional Imaging in Lymphoma -- Multiple Myeloma and Other Hematological Malignancies -- Malignant Tumors of the Musculoskeletal System -- Advanced MRI Techniques of Soft Tissue Tumors -- Bone Malignancies -- Bone Metastasis -- Functional Imaging of Pediatric Malignancies -- Malignant Melanoma.
  • Introduction of cancer prevention -- Assessing human and economic benefits of cancer prevention -- The role of diet, physical activity and body composition in cancer prevention -- Hereditary risk for cancer -- Human categories and health: the power of the concept of ethnicity -- Complementary and alternative approaches to cancer prevention -- The drug development process -- Developing topical prodrugs for skin cancer prevention -- Skin cancer prevention -- Colorectal cancer prevention -- Lung cancer prevention -- Breast cancer prevention -- Prostate cancer prevention -- Cervical and endometrial cancer prevention -- Ovarian cancer prevention -- Cancer survivorship.
  • Introduction to cancer prevention -- Assessing human and economic benefits of cancer prevention -- The role of diet, physical activity, and body composition in cancer prevention -- Innate and adaptive immune responses to cancer -- Hereditary risk for cancer -- Cancer health disparties -- Human categories and health : the power of the concept of ethnicity -- Complementary and alternative approaches to cancer prevention -- Telemedicine, telehealth, and e-health technologies in cancer prevention -- Global cancer prevention -- Sunscreen-based skin protection against solar insult : molecular mechanisms and opportunities -- Skin cancer prevention -- Prevention of colorectal cancer -- Lung cancer prevention -- Breast cancer prevention -- Prevention of prostate cancer -- Cervical cancer prevention -- Ovarian cancer prevention -- Endometrial cancer prevention -- Cancer survivorship.
  • Introduction and the nature of radiosurgery -- Principles of stereotaxy -- Ionizing radiation and its effects on living tissue -- Biological effects of ionizing radiation -- Ionizing radiation and clinical practice -- Gamma knife development from 1967 to 2010 -- Radiophysics, radiobiology and the gamma knife -- Preparation for treatment planning -- Dose plan indices -- Gamma knife surgery and computer networks -- Aims of gamma knife surgery -- Principles of information and follow up -- Vestibular schwannomas -- Meningiomas -- Gamma knife for cerebral metastases -- Intraparenchymal intrinsic brain tumors -- Tumors of the pituitary region -- Less common skull base tumors -- Gamma knife for cerebral vascular anomalies -- Trigeminal neuralgia -- Diverse functional indications -- Rare tumors and other lesions -- Orbital indications -- Conclusion and possible future trends.
  • The Historical Perspective of Gastric Cancer -- Epidemiology of Gastric Cancer -- Molecular Mechanisms in Gastric Carcinogenesis -- Pathology of Gastric Cancer -- Role of HER2 in Gastric Cancers -- Pathophysiology of Hereditary Diffuse Gastric Cancer -- Western Perspective and Epidemiology of Gastric Cancer -- Diagnosis, Staging and Workup of Gastric Cancer -- Endoscopy and Endoscopic Ultrasound Examination of the Stomach -- The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer -- Endoscopic Resection for Gastric Cancer -- Methods of Reconstruction -- BI, BII, Roux-en-Y, Jejunal Interposition, Proximal Gastrectomy and Pouch Reconstruction -- Lymphadenectomy -- D1, D2 and D3 -- Open Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy -- Laparoscopic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Robotic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Managing Early and Late Postoperative Complications Following Gastric Surgery -- Hereditary Diffuse Gastric Cancer -- Surveillance after Gastric Resection -- Surgical Trials for Gastric Cancer -- Neoadjuvant and Adjuvant Treatment -- Strategies and Clinical Trials -- Western Perspective -- Adjuvant and Neoadjuvant Treatment: Standard Treatment and Clinical Trials in the East -- Radiation Treatment for Gastric Cancer -- Targeted Therapy and Novel Agents for the Treatment of Gastric Cancer: A View towards the Future.
  • Also available: Print – 2005
  • PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Bénard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
  • Also available: Print – 2007
    Adenovector-mediated cancer gene therapy / Bingliang Fang and Jack A. Roth -- Efficacy, toxicity, and immunogenicity of adenoviral vectors / Dmitry M. Shayakhmetov -- Lentiviral and retroviral vector systems / Renata Stripecke and Noriyuki Kasahara -- Vaccinia and pox-virus / Sricharan Chalikonda and David L. Bartlett -- Herpes simplex virus as a therapy for cancer / Ian J. Mohr -- Alphavirus vectors for gene therapy applications / Kenneth Lundstrom -- Vesicular stomatitis virus and RNA viruses as gene therapy vectors / Glen N. Barber -- Parvovirus vectors / Selvarangan Ponnazhagan -- Nonviral vector systems / Pui-yan Lee and Leaf Huang -- Oncogenes, tumor suppressor genes, and apoptosis-inducing genes utilized in cancer gene therapy / Lidong Zhang and Bingliang Fang -- Gene silencing therapy against cancer / Chao-Zhong Song -- Tumor targeting-retargeted adenovirus / Masato Yamamoto and David T. Curiel -- Oncolytic herpes simplex for gene therapy in preclinical and clinical trials / Richard H. Pin ... [et al.] -- Cytokine gene therapy for genitourinary cancer / Terry L. Timme ... [et al.] -- Combination of gene therapy with radiation / Anupama Munshi and Raymond E. Meyn -- Gene transfer for chemoprotection and enrichment of hematopoietic stem cells / Justin C. Roth and Stanton L. Gerson -- Nonviral genetic vaccines for cancer / Steven R. Little, Daniel G. Anderson, and Robert Langer -- Gene therapy targeted at angiogenesis and lymphangiogenesis for cancer treatment / Anita T. Tandle and Steven K. Libutti -- Tumor-specific replicating adenoviruses : delta 24 for human gliomas / Giacomo G. Vecil, Juan Fueyo, and Frederick F. Lang -- Problems, side effects, and disappointments in clinical cancer gene therapy / Ta-Chiang Liu and David H. Kirn -- Trials and tribulations in developing clinical trials of gene therapy : E1A for breast or ovarian cancer / Naoto T. Ueno ... [et al.] -- Phase I clinical experience with intravenous administration of PV701, an oncolytic virus / Andrew L. Pecora and Robert M. Lorence -- MDA-7/IL-24 as a multi-modality therapy for cancer / Sunil Chada ... [et al.] -- Development of therapeutic genes for breast cancer treatment / Mien-Chie Hung and Duen-Hwa Yan -- Steps in a translational cancer gene therapy trial / Urs W. von Holzen and Stephen G. Swisher.
  • Ex Vivo Gene Therapy: Utilization of Genetic Vectors for the Generation of Genetically Modified Cell Products for Therapy -- Targeting Tumor Vasculature Using Adeno-Associated Virus Phage Vectors Coding Tumor Necrosis Factor-a -- Viral Insertion Site Detection and Analysis in Cancer Gene Therapy -- Targeted Systemic Delivery of Therapeutic siRNA -- Bacterial Delivery of RNAi Effectors -- Gene-Directed Enzyme Prodrug Cancer Therapy -- Electroporation Gene Therapy -- Toxin-Based Cancer Gene Therapy: Under the Control of Oncofetal H19 Regulatory Sequences -- Gene Therapy in Radiotherapy of Cancer -- Advances in Oncolytic Virotherapy for Brain Tumors -- Oncolytic Adenoviruses in the Treatment of Cancer in Humans -- Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers -- Reoviral Therapy for Cancer: Strategies for Improving Antitumor Efficacy Using Radio- and Chemotherapy -- Selectively Replicating Herpes Simplex Viral Vectors -- Modified Oncolytic Herpesviruses for Gene Therapy of Cancer -- The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent -- Poxvirus-Based Strategies for Combined Vaccine and Tumor Microenvironment Manipulation -- Genetically Engineered (T Cell Receptor) T Cells for AdoptiveTherapy -- Genetically Modified Dendritic Cell Vaccines for Solid Tumors -- Dendritic Cell Vaccination -- Chemokine Gene-Modified Dendritic Cells for Cancer Therapy -- The Use of T Cell Costimulation to Enhance the Immunogenicity of Tumors -- Clinical Application of Plasmid-Based Cancer Vaccines -- Lentivector Vaccines -- Therapeutic Efficacy and Systemic Antitumor T Cell Immunity Induced by RheoSwitch-Regulated IL-12 Expression after Intratumoral Injection of Adenovirus Vector or Vector-Transduced Dendritic Cells -- Clinical Trials Using LV-P₁₄₀K-MGMT for Gliomas -- RNA Interference Therapeutics for Tumor Therapy: Promising Work in Progress -- MGMT Stem Cell Selection and Protection: Preclinical Large Animal and Clinical Studies -- Cytidine Deaminase in Myeloprotective Gene Therapy -- Genetically Engineered Salmonella typhimurium for Targeted Cancer Therapy -- Imaging of Oncolytic Virus Gene Expression -- Lentiviral-Encoded Sodium Iodide Symporter-Mediated Cancer Gene Therapy -- Bacteriophage: From Bacteria to a Successful Targeted Systemic Gene Delivery for Cancer -- Issues in Moving Gene Therapy Approaches to Early Clinical Trials -- The FDA Review Process for Cancer Gene Therapy -- Ethics in Translational Gene Transfer Research.
  • General principles of tumor immunology -- A perspective on cancer immunology and immunotherapy -- Tumor antigens -- T cells and antigen recognition -- The role of natural killer T cells in tumor immunity -- Immunomodulatory molecules of the immune system -- HLA class I antigen abnormalities in tumors -- The local tumor microenvironment -- Tumor vaccines -- Peptide and protein vaccines for cancer -- DNA vaccines against cancer -- Recombinant viral and bacterial vaccines -- Dendritic cell vaccines -- Whole cell vaccines -- Carbohydrate vaccines against cancer -- Passive immunotherapy approaches -- Monoclonal antibody therapy of cancer -- Adoptive cellular therapy for the treatment of cancer -- Checkpoint blockade and combinatorial immunotherapies -- Clinical tumor immunotherapy -- General approaches to measuring immune responses -- Interferon therapy -- High dose interleuken-2 therapy -- Monoclonal antibodies in cancer therapy -- Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy.
  • This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
  • Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
  • Also available: Print – 2008
  • Genetics for surgeons 2005
    NCBI Bookshelf
  • Also available: Print – 2005
  • Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist?s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
  • Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
  • Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.
  • Aging and cancer, what oncologists need to know / Arti Hurria, Lodovico Balducci -- Assessing the older cancer patient / Melissa Cohen, David Reuben, Arash Naeim -- Cancer screening in older adults / Louise C. Walter -- Physiological consequences of aging / Bindu Kanapuru, William B. Ershler -- Assessment and impact of comorbidity in older adults with cancer / Athanasios Karampeasiz, Martine Extermann -- Geriatric syndromes defined and explained for oncology practice / Miriam B. Rodin -- Family caregivers / Betty R. Ferrell, Polly Mazanec -- Surgical management of the older patient with cancer / David M. Heimann, M. Margaret Kemeny -- Chemotherapy for the older adult with cancer / Supriya Mohile, Nail Nagovskiy, Lodovico Balducci -- Radiation therapy in geriatric oncology / Sarah E. Hoffe, Mark S. Russell -- Palliative care, special considerations for older adults with cancer / Genevieve N. Thompson, Harvey M. Chochinov.
  • This volume provides a compact, concise and up-to-date resource for pathologists and clinicians who are involved in women's health. The book summarizes the incidence, epidemiology and risk factors for cervical adenocarcinoma, while reviewing the normal histology of the cervix and glandular lesions of the cervix. The cytological appearance of glandular lesions of the cervix and their mimics is amply illustrated and discussed. Management of glandular lesions is also outlined. Written by authorities in the field, Glandular Lesions of the Uterine Cervix: Cytopathology with Histologic Correlates is of great value to cytopathologists, surgical pathologists, gynecologic oncologists and surgeons.
  • Also available: Print – 2012
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
  • Glioma signaling 2013
    Also available: Print – 2013
  • Gliomas 2009
    Also available: Print – 2009
    Part I. Gliomas -- Astrocytic tumors / Markus J. Riemenschneider and Guido Reifenberger -- Molecular pathology of oligodendroglial tumors / Christian Hartmann and Andreas von Deimling -- Ependymal tumors / Martin Hasselblatt -- Pediatric gliomas / Stefan Pfister and Olaf Witt -- Hereditary tumor syndromes and gliomas / David Reuss and Andreas von Deimling -- Part II. Management of gliomas -- Surgical management of intracranial gliomas / Matthias Simon and Johannes Schramm -- Radiation therapy / Stephanie E. Combs -- Adjuvant therapy / Wolfgang Wick and Michael Weller -- Other experimental therapies for glioma / Manfred Westphal and Katrin Lamszus -- Neurotoxicity of treatment / Pasquale Calabrese and Uwe Schlegel -- Neuroimaging / R. Klingebiel and G. Bohner -- Part III. Angiogenesis in gliomas / Marcia Machein and Lourdes Sánchez de Miguel -- Gene regulation by methylation / Wolf C. Mueller and Andreas von Deimling -- Brain tumor stem cells / Christian Nern, Daniel Sommerlad, Till Acker and Karl H. Plate.
  • Glycosylation and cancer 2015
  • Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes. Aids the development of therapeutic treatments for cancer. Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research.
  • Regulation of tumor initiation and metastatic progression by eph receptor tyrosine kinases / Jin Chen -- Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis / Ombretta Salvucci, Giovanna Tosato -- Semaphorin signals tweaking the tumor microenvironment / Claudia Muratori, Luca Tamagnone -- Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors / Christian Gespach -- Roundabout way to cancer / Mimmi S. Ballard, Lindsay Hinck -- Role of the VEGF/VEGFR axis in cancer biology and therapy.
  • Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.
  • This study (EGF104911) is designed to evaluate the efficacy and safety of lapatinib in patients with advanced or metastatic breast cancer. Eligible subjects must have ErbB2 overexpressing tumors and are refractory to treatment with anthracycline, taxanes and trastuzumab containing regimens. The study data obtained from EGF104911 will be combined with the data from EGF100642 and integrated analysis will be carried out in order to enhance the credibility of the study results.
  • Gynecologic cancer 2006
    Multidisciplinary care of patients with gynecologic cancers / David M. Gershenson ... [et al.] -- Prevention and early detection of endometrial and ovarian cancers / Karen H. Lu -- Preinvasive disease of the lower genital tract / Andrea Milbourne -- Selected topics in gynecologic pathology / Anais Malpica, Michael T. Deavers, and Elvio G. Silva -- Imaging of gynecologic malignancies / Revathy Iyer -- Contemporary treatment of vaginal and vulvar cancers / Patricia J. Eifel and Thomas W. Burke -- Treatment of early cervical cancer / Charles F. Levenback -- Treatment of locally advanced cervical cancer / Anuja Jhingran, Patricia J. Eifel, and Pedro T. Ramirez -- Uterine sarcomas / Lois M. Ramondetta ... [et al.] -- Treatment of endometrial cancer / Lois M. Ramondetta ... [et al.] -- Surgery for ovarian cancer / Judith K. Wolf and J. Taylor Wharton -- Chemotherapy for epithelial ovarian cancer / Michele L. Donato ... [et al.] -- Treatment of rare ovarian malignancies / Jubilee Brown and David M. Gershenson -- Gestational trophoblastic disease / Hui T. See ... [et al.] -- Fertility-sparing options for treatment of women with gynecologic cancers / Pedro T. Ramirez -- Quality of life and sexual functioning / Diane C. Bodurka and Charlotte C. Sun -- Palliative care for gynecologic malignancies / Florian Strasser, Michael W. Bevers, and Eduardo Bruera.
  • During this age of advanced technology, there is an incredible amount of dynamic literature surrounding the diagnosis and treatment of gynecologic cancers. Despite this information surplus, house officers and junior faculty studying gynecologic oncology indicate a need for a reliable, easily accessible, streamlined resource for everyday use. Gynecologic Oncology: A Pocketbook is a collaborative effort that combines the perspectives of expert faculty and fellows in training in the field of gynecologic oncology. Not only is it incredibly portable, but the format in which the information is presented (bullet point, outline, tables and diagrams) allows for rapid access to valuable information and is unique amongst existing texts. This distinct pocketbook will provide the information needed to care for patients with gynecologic malignancies appropriately and will promote critical thinking throughout treatment.
  • Imaging of gynecologic malignancies -- The use of sectional imaging with CT and MRI for image-guided therapy -- The physics of CT and MR imaging -- The use of positron emission tomographic imaging for image-guided therapy -- Image-guidance in external beam planning for locally advanced cervical cancer -- Physics perspectives on the role of 3D imaging -- Image-guided treatment planning and therapy in postoperative gynecologic malignancies -- The integrating of 3D imaging with conformal radiotherapy for vulvar and vaginal cancer -- Adaptive contouring of the target volume and organs at risk -- Clinical aspects of treatment planning -- Radiobiological aspects of brachytherapy in the era of 3D imaging -- Physics for image-guided brachytherapy -- Australia: Peter Maccullum Cancer Center, Melbourne -- Austria: Medical University of Vienna, Vienna -- Belgium: University Hospital, Leuven -- Denmark: Aarhus University Hospital, Aarhus -- France: Institut Gustave-Roussy, Paris -- Great Britain: Mount Vernon Cancer Center, Middlesex -- India: Tata Memorial Hospital, Mumbai -- The Netherlands: University Medical Center, Utrecht -- USA: Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston -- USA: Medical College of Wisconsin, Milwaukee -- Postoperative vaginal cylinder brachytherapy in an era of 3D imaging -- Image-based approaches to interstitial brachytherapy -- Outcomes related to the disease and the use of 3D-based external beam radiation and image-guided brachytherapy -- Morbidity related to the use of 3D-based external beam radiation and image-guided brachytherapy.
  • This book provides a detailed guide to the use and interpretation of color Doppler ultrasound, CT, and MR imaging in patients with gynecological disorders. The advantages and limitations of each modality in imaging different pathologies are clearly presented, and advice is provided on the most appropriate option when ultrasound does not permit a definite diagnosis or fails to determine the precise extension of a lesion. Throughout, emphasis is placed on the importance of microscopic and macroscopic findings for a full understanding of the radiological appearances, and relevant points from the basic sciences are also highlighted. Special attention is paid to issues of differential diagnosis and imaging results that are characteristic of a particular type of lesion. The authors are recognized experts in the field who draw upon their considerable experience to provide an up-to-date reference book highly relevant to everyday clinical practice.
  • There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.
  • SECTION I: BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY AND MOLECULAR THERAPY -- 1. Biologic and pharmacologic basis of cancer chemotherapy / Roland T. Skeel -- 2. Biologic basis of molecular targeted therapy / Osama E. Rahma, Samir N. Khleif -- 3. Systemic assessment of the patient with cancer and consequences of treatment / Roland T. Skeel -- 4. Selection of treatment with the patient with cancer / Roland T. Skeel -- SECTION II: CHEMOTHERAPY AND MOLECULAR THERAPY OF HUMAN CANCER -- 5. Carcinonas of the head and neck / Barbara A. Murphy -- 6. Carcinomas of the lung / David E. Gerber, Joan H. Schiller -- 7. Carcinomas of the gastrointestinal tract / Maxwell Vergo, AI B. Benson III -- 8. Carcinomas of the pancreas, liver, gallbladder, and bile ducts / Timothy J. Kennedy, Steven K. Libutti -- 9. Carcinomas of the breast / Patrick Glyn Morris, Clifford A. Hudis -- 10. Gynecologic cancer / Thomas McNally, Richard T. Penson, Chau Tran, Michael J. Birrer -- 11. Urologic and male genital cancers / Brendan D. Curti, Craig R. Nichols -- 12. Kidney cancer / Mark T. Andolina, Colleen Darnell, Olivier Rixe -- 13. Thyroid and adrenal cancinomas / Haitham S. Abu-Lebdeh, Michael E. Menefee, Keith C. Bible -- 14. Melanomas and other cutaneous malignancies / Ragini Kudchadkar, Jeffrey S. Weber -- 15. Primary and metastatic brain tumors / April Fitzsimmons Eichler, Tracy T. Batchelor -- 16. Soft tissue sarcomas / Robert S. Benjamin -- 17. Bone sarcomas / Robert S. Benjamin -- 18. Acute leukemias / Olga Frankfurt, Martin S. Tallman -- 19. Chronic leukemias / Khaled el-Shami, Bruce D. Cheson -- 20. Myeloproliferative neoplasms and myledysplastic syndromes / Elias Jabbour, Hagop Kantarjian -- 21. Hodgkin lymphoma / Richard S. Stein, David S. Morgan -- 22. Non-Hodgkin lymphoma / Mark Roschewski, Wyndham H. Wilson -- 23. Multiple myeloma, other plasma cell disorders, and primary amyloidosis / Rachid Baz, Mohamad A. Hussein -- 24. Metastatic cancer of unknown origin / James M. Leonardo -- 25. HIV-associated malignancies / Thomas S. Uldrick, Mark N. Polizzotto, Robert Yarchoan -- SECTION III: SUPPORTIVE CARE OF PATIENTS WITH CANCER -- 26. Side effects of chemotherapy and molecular targeted therapy / Janelle M. Tipton -- 27. Infections: etiology, treatment, and prevention / Thomas J. Walsh, Joan M. Duggan -- 28. Transfusion therapy, bleeding, and clotting / Mary R. Smith, NurJehan Quraishy -- 29. Oncology emergencies and critical care issues: spinal cord compression, cerebral edema, Superior Vena Cava Syndrome, anaphylaxis, respiratory failure, Tumor Lysis Syndrome, hypercalcemia, and bone metastasis / Roland T. Skeel -- 30. Malignant pleural, peritoneal, and pericardial effusions and meningeal infiltrates / Rekha T. Chaudhary -- 31. Cancer pain / Richard T. Lee, Michael J. Fisch -- 32. Emotional and psychiatric problems in patients with cancer / Kristi Skeel Williams, Kathleen S.N. Franco-Bronson -- SECTION IV: CHEMOTHERAPEUTIC AND MOLECULAR TARGETED AGENTS AND THEIR USE -- 33. Classification, use, and toxicity of clinically useful chemocherapy and molecular targeted therapy / Roland T. Skeel -- Appendix A: Nomogram for determining body surface area of adults from height and mass -- Appendix B: Nomogram for determining boy surface area of children from height and mass.
  • Biologic and pharmacologic basis of cancer chemotherapy and biotherapy / Roland T. Skeel and Samir N. Khleif -- Systemic assessment of the patient with cancer and long-term consequences of treatment / Roland T. Skeel -- Selection of treatment for the patient with cancer / Roland T. Skeel -- Antineoplastic drugs and biologic response modifiers : classification, use, and toxicity of clinically useful agents / Roland T. Skeel -- High-dose chemotherapy and hematopoietic stem cell transplantation in hematologic malignancies / Roberto Rodriguez and Chatchada Karanes -- Carcinomas of the head and neck / Harlan A. Pinto -- Carcinoma of the lung / Sophie Sun and Joan H. Schiller -- Carcinomas of the gastrointestinal tract / Al B. Benson, III -- Carcinomas of the pancreas, liver, gallbladder, and bile ducts / Rekha T. Chaudhary -- Carcinoma of the breast / Iman Mohamed -- Gynecologic cancer / Stephen Andrews -- Urologic and male genital cancers / Joseph S. Chan, Scott B. Saxman, and Craig R. Nichols -- Kidney cancer / Walter D. Y. Quan, Jr. and Mikhail Vinogradov -- Thyroid and adrenal carcinomas / Haitham S. Abu-Lebdeh and Samir N. Khleif -- Melanomas and other skin malignancies / Karen S. Milligan and Walter D. Y. Quan, Jr. -- Primary and metastatic brain tumors / April F. Eichler and Tracy T. Batchelor -- Soft tissue sarcomas / Robert S. Benjamin -- Bone sarcomas / Robert S. Benjamin -- Acute leukemias / Olga Frankfurt and Martin S. Tallman -- Chronic leukemias / Peter White and Paul R. Walker -- Myeloproliferative diseases and myelodysplastic syndromes / Peter White and Paul R. Walker -- Hodgkin's lymphoma / Richard S. Stein and David S. Morgan -- Non-Hodgkin's lymphoma / Richard S. Stein and John P. Greer -- Multiple myeloma, other plasma cell disorders , and primary amyloidosis / Rachid Baz and Mohamad A. Hussein -- Metastatic cancer of unknown origin / James M. Leonardo -- Human immunodeficiency virus / Mary E. Cianfrocca -- Side effects of cancer chemotherapy / Janelle M. Tipton -- Infections : etiology, treatment, and prevention / Joan M. Duggan -- Transfusion therapy, bleeding, and clotting / Mary R. Smith and NurJehan Quraishy -- Oncology emergencies and critical care issues, anaphylaxis, spinal cord compression, cerebral edema, superior vena cava syndrome, hypercalcemia, tumor lysis syndrome, and respiratory failure / Roland T. Skeel -- Malignant pleural, peritoneal, and pericardial effusions and meningeal infiltrates / Rekha T. Chaudhary -- Cancer pain / Michael J. Fisch and Charles S. Cleeland -- Emotional and psychiatric problems in patients with cancer / Kathleen S. N. Franco-Bronson and Kristi S. Williams.
  • Part I: -- Burden -- Cancer survivorship: a bird's eye view from an insider / Michael Feuerstein -- The burden of cancer survivorship: a pandemic of treatment success / Steven N. Wolff -- Quality of care / Craig C. Earle -- Quality of life in long-term cancer survivors / Joan Bloom, Soo H. Kang, Dana M. Petersen, and Susan L. Stewart -- Health care disparities / Salewa Oseni and Ismail Jatoi -- Measuring quality of life in cancer survivors / David Victorson, David Cella, Lynne Wagner, Laura Kramer, and Mary Lou Smith -- Part II: -- Common problems -- Exercise motivation and behavior change / Kerry S. Corneya, Kristina H. Karvinen, and Jeffrey K.H. Vallance -- Fatigue / Alexander V. Ng, Carlynn A. Alt, and Elizabeth M. Gore -- Pain / Victor T. Chang and Ryuichi Sekine -- Depression / Peter C. Trask and Timothy Pearman -- Interpersonal relationships / Andrea A. Thorton and Martin A. Perez -- Adaptation in the face of advanced cancer / Carissa A. Low, Tammy Beran, and Annette L. Stanton -- Part III: -- Secondary prevention -- Restoring emotional well-being: a model / Robert W. Lent -- Physical activity for cancer survivors: potential benefits and guidelines / Clare Stevinson, Kristin L. Campbell, Christopher M. Sellar, and Kerry S. Courneya -- Nutrition and weight management in cancer survivors / Virginia Uhley and K. L. Catherine Jen -- Management of chemotherapy related cognitive dysfunction / Robert J. Ferguson, Raine Riggs, Tim Ahles, and Andrew J. Saykin -- Smoking cessation and cancer survivors / Jamie S. Ostroff and Lara K. Dhingra -- Psychological distress, depression, and anxiety / Arthur M. Nezu and Christine Maguth Nezu -- Managing daily and long-term stress / Linda E. Carlson and Michael Speca -- Pain and function: a psychosocial perspective / Michael J.L. Sullivan, Pascal Thibault, Andre Savard, and Ana Velly -- Work / Jos Vebeek and Evelien Spelten -- Comprehensive long-term follow-up: cancer survivorship centers / Linda A. Jacobs, Jane Alavi, Angela DeMichele, Steven Palmer, Carrie Stricher, and David Vaughn -- Part IV: -- Survivor and provider perspectives -- Survivor perspectives on quality care / Kathryn McPherson and Rod MacLeod -- Living with advanced cancer / Sheila Payne -- Part V: -- International perspective -- Global considerations / Patricia A. Findley -- Part VI: -- Future directions -- Cancer survivorship: research, practice, and policy / Michael Feuerstein.
  • This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1?2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.
  • Introduction to Cutaneous Melanoma -- Clinical Features and Classification -- Diagnosis, Staging, and Follow-up -- Treatment of Primary Tumor and Locoregional Disease -- Treatment of Distant and Irresectable Metastatic Disease -- Emerging Therapies and Combination Approaches.
  • Skin cancer -- Central nervous system -- Malignant and benign diseases of the eye and orbit -- Cancer of the ear -- Nasopharyngeal cancer -- Nasal cavity and paranasal sinus cancer -- Oropharyngeal cancer -- Cancer of the lip and oral cavity -- Larynx and hypopharynx cancer -- Salivary gland tumors -- Thyroid cancer -- Unusual neoplasms of the head and neck -- Management of the neck and unknown primary of the head and neck -- Small cell lung cancer -- Non-small cell lung cancer -- Mesothelioma and thymic tumors -- Breast cancer -- Esophageal cancer -- Gastric cancer -- Pancreatic cancer -- Hepatobiliary cancer -- Colorectal cancer -- Anal cancer -- Renal call carcinoma -- Bladder cancer -- Prostate cancer -- Cancer of the penis -- Testicular cancer -- Cervical cancer -- Endometrial cancer -- Ovarian cancer -- Vaginal cancer -- Vulvar cancer -- Urethral cancer -- Hodgkin's lymphoma -- Non-Hodgkin's lymphoma -- Cutaneous lymphomas -- Multiple myeloma and plasmacytoma -- Bone tumors -- Soft-tissue sarcoma -- Pediatric (Non-CNS) tumors -- Palliation and benign conditions -- Clinical radiobiology and physics.
  • v. 1. Molecular genetics; Lung and breast carcinomas -- v. 2. Molecular pathology; Colorectal carcinoma and prostate carcinoma -- v. 3. Molecular genetics; Liver carcinoma and pancreatic carcinoma -- v. 4. Molecular genetics; Gastrointestinal carcinoma and ovarian carcinoma.
  • This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma. The Handbook was commissioned to address an unmet need for a book of this kind in the myeloma field and to provide busy healthcare professionals with an informative and educational review of the current and emerging treatment recommendations for multiple myeloma. Myeloma is a type of bone marrow cancer arising from plasma cells and is the second most common form of bone marrow cancer, but represents just 1% of all cancers. The causes of myeloma are not fully understood but it is thought to be caused by an interaction of both genetic and environmental factors. This Handbook discusses these issues as well the latest developments in the field and will be an invaluable source of topical information for all healthcare professionals with an interest in multiple myeloma.
  • 1. Approach to the Anemic Child -- 2. Hemolytic Anemia -- 3. Sickle Cell Disease -- 4. Thalassemia -- 5. Transfusion Medicine -- 6. Chelation Therapy -- 7. Approach to the Bleeding Child -- 8. Von Willebrand Disease -- 9. Hemophilia -- 10. The Child with Thrombosis -- 11. The Neutropenic Child -- 12. Thrombocytopenia -- 13. Evaluation of the Child with a Suspected Malignancy -- 14. Oncologic Emergencies -- 15. Acute Leukemias -- 16. Central Nervous System Tumors -- 17. Hodgkin and Non-Hodgkin Lymphoma -- 18. Wilms Tumor -- 19. Neuroblastoma -- 20. Sarcomas of the Soft Tissues and Bone -- 21. Germ Cell Tumors -- 22. Rare Tumors of Childhood -- 23. Histiocytic Disorders -- 24. Hematopoietic Stem Cell Transplantation -- 25. Supportive Care of the Child with Cancer -- 26. Central Venous Catheters -- 27. Management of Fever in the Child with Cancer -- 28. Acute Pain Management in the Inpatient Setting -- 29. Palliative Care -- 30. Chemotherapy Basics -- 31. Guide to Procedures -- 32. Treatment of Chemotherapy Extravasations.
  • Pt. 1. Phase I trials -- pt. 2. Phase II trials -- pt. 3. Phase III trials -- pt. 4. Exploratory and high -dimensional data analyses.
  • 1. Overview : therapeutic biomarkers in cancer / Sherry X. Yang and Janet E. Dancey -- 2. Statistical considerations in the development and evaluation of therapeutic biomarkers in cancer / Lisa M. McShane, Edward L. Korn, and Boris Freidlin -- 3. Role of biomarkers in clinical development of cancer therapies / Helen X. Chen -- 4. HER-2 as a prognostic and predictive biomarker in cancer / Suparna B. Wedam and Stanley Lipkowitz -- 5. Hormone receptors and endocrine therapy in breast cancer / Sherry X. Yang -- 6. Predictive biomarkers for epidermal growth factor receptor agents in non-small cell lung cancer / John Hilton, Penelope A. Bradbury, and Janet Dancey -- 7. Markers of sensitivity and resistance to EGFR inhibitors in colorectal cancer / Jose G. Monzon and Janet Dancey -- 8. Targeting BCR-ABL for molecular therapy of chronic myelogenous leukemia / Shamudheen Rafiyath, Guoqing Wei, and Delong Liu -- 9. Gastrointestinal stromal tumors : from molecular pathogenesis to therapy / Joaquina Baranda, Rashna Madan, and Andrew K. Godwin -- 10. PML/RARa fusion gene and response to retinoic acid and arsenic trioxide treatment / Alicja M. Gruszka and Myriam Alcalay -- 11. Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity -- 12. UGT1A1 polymorphisms and mutations lead to irinotecan-induced toxicity / K.M. Reece and W.D. Figg -- 13. The 21-gene recurrence score and benefit of chemotherapy in estrogen receptor-positive breast cancer / Petra Rietschel and Joseph A. Sparano -- 14. Mammaprint for individualized recurrence risk assessment and treatment recommendations for early-stage breast cancer patients / Sonal J. Desai and Tianhong Li -- 15. BRCA mutation and PARP inhibitors / Marcie K. Weil ... [et al.] -- 16. EML4-ALK fusion gene and therapy with ALK-targeted agents in non-small cell lung cancer / Vimal Patel and Biren Saraiya -- 17. BRAF-targeted therapy in metastatic melanoma / Noori Kim and April Deng.
  • This book is a collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals, and is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book. This volume covers Head and Neck cancer in such a way that it covers the ancient history of these tumors to modern diagnostic methods. It covers the various aspects of treatment and the healing of the these patients. Various aspects of molecular biology, the histology, and diagnostic methods are also discussed. Links are made between subject matter that will give readers new insight to these tumors. This volume will give a broad understanding to the various aspects related to Head and Neck cancer in general, and will provide the foundation for anyone to explore the subject matter in greater detail.
  • Head and neck cancer 2010
    Each volume in the Early Diagnosis and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You"ll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Diagnosis and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for head and neck cancers. Apply expert advice on the best next-step plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered.
  • General principles of head and neck pathology -- Clinical evaluation of the head and neck cancer patient -- Prognostic factors in patients with head and neck cancer -- Radiologic evaluation of the head and neck cancer patient -- Novel radiation therapy techniques in the management of head and neck cancer -- New approaches: robotics and endoscopic head and neck surgery -- Targeted agents in squamous cell carcinoma of the head and neck -- Multidisciplinary reconstruction of the head and neck: general principles -- Dental oncology and maxillofacial prosthetics -- Interdisciplinary symptom management -- Evaluation and rehabilitation of speech, voice, and swallowing functions after treatment of head and neck cancer -- Human papillomavirus -- associated head and neck carcinoma -- Chemoprevention -- Management of the neck -- Metastatic cancer to the neck from an unknown primary site -- Cancer of the oral cavity -- Cancer of the oropharynx -- Cancer of the larynx -- Cancers of the hypopharynx and cervical esophagus -- Cancer of the nasal vestibule, nasal cavity paranasal sinuses, anterior skull base, and orbit: surgical management -- Cancer of the nasal cavity and paranasal sinus: radiation therapy and chemotherapy management -- Cancer of the nasopharynx -- Basal and squamous cell skin cancers -- Melanoma of the head and neck -- Management of salivary gland tumors -- Primary and recurrent disease of the lateral skull base -- Paragangliomas of the head and neck -- Cancer of the thyroid and parathyroid -- Soft tissue and bone sarcomas of the head and neck -- Systemic targeted therapy for recurrent and metastatic head and neck squamous cell cancer.
  • Also available: Print – 2009
    General principles of management of head and neck cancer -- General principles of head and neck pathology / Bruce M. Wenig and Jean-Marc Cohen -- Prognostic factors in patients with head and neck cancer / Benjamin D. Smith and Bruce G. Haffty -- General clinical evaluation of the head and neck patient / Douglas K. Frank and Roy B. Sessions -- Special radiologic imaging considerations in the evaluation of squamous cell cancer of the head and neck / Suresh K. Mukherji -- Novel radiation therapy techniques in the management of head and neck cancer / Avraham Eisbruch -- Dental oncology and maxillofacial prosthetics / Jack W. Martin, James C. Lemon, and Mark C. Chambers -- Total supportive care: nutrition, symptom management, pain, and psychosocial support / Elise Carper, Stewart B. Fleishman, and David Seres -- General principles of rehabilitation of speech, voice, and swallowing function after treatment of head and neck cancer / Jan S. Lewin and Katherine A. Hutcheson -- Site-specific principles of management of head and neck cancer -- Management of the Neck-Surgery -- Management of the neck: radiation therapy and chemotherapy / Kenneth S. Hu, Harry Quon, and Louis B. Harrison -- Metastatic cancer to the neck from an unknown primary site -- Cancer of the oral cavity -- Cancer of the oropharynx -- Early-stage cancer of the larynx -- Advanced stage cancer of the larynx -- Cancer of the hypopharynx and cervical esophagus -- Cancer of the nasal vestibule, nasal cavity, and paranasal sinus: surgical management / Mark S. Persky and Abtin Tabaee -- Cancer of the nasal cavity and paranasal sinus: radiation therapy and chemotherapy management -- Cancer of the nasopharynx -- Basal and squamous cell skin cancers -- Melanoma of the head and neck -- Malignant salivary gland tumors -- Cancers involving the skull base and temporal bone / Ivo P. Janecka, et. al. -- Pargangliomas of the head and neck -- Cancer of the thyroid and parathyroid -- Soft tissue and bone sarcomas of the head and neck -- Cancer of the orbit: surgical management -- Cancer of the orbit and ocular structures: radiation therapy and management / Jorge E. Freire, -- Systemic targeted therapy for recurrent and metastatic head and neck cancer / Syed M. Ahmed, Victoria Villaflor, and Ezra E. W. Cohen -- Basic science and epidemiology of head and neck cancer -- Molecular biology of head and neck cancer / Patrick K. Ha, Joseph A. Califano, and David Sidransky -- Molecular and genetic predisposition for the squamous cell carcinoma of the head and neck / Qingyi Wei, Kathryn L. Patterson, Erich M. Sturgis, and Margaret R. Spitz -- Angiogenesis and metastases in head and neck cancer / Chad E. Galer and Jeffrey N. Myers -- Human papillomavirus and prevention and therapy of head and neck cancer / Maura L. Gillison -- Chemoprevention of head and neck cancer / Anne Tsao and Vassiliki A. Papadimitrakopoulou.
  • Epidemiology and Aetiology of Head and Neck Cancers -- Head and Neck Cancer Prevention -- Cellular and Molecular Pathology of Head and Neck Tumors -- Oncogenomics/Proteomics of Head and Neck Cancers -- Genetics and Epigenetics of Head and Neck Cancer -- Immunology of Head and Neck Cancer -- HPV and EBV in Head and Neck Cancer -- Head and Neck Cancer Staging and Prognosis: Perspectives of the UICC and the AJCC -- Biomarkers in Head and Neck Cancer -- Hypoxia in Head and Neck Cancers: Clinical Relevance and Treatment -- Translational Research in Head and Neck Oncology -- Preclinical Models of Head and Neck Squamous Cell Carcinoma -- Morphologic Investigations in Head and Neck Cancer -- Ultrasound Investigations in Head and Neck Cancer Patients -- Functional Imaging -- Sentinel Node Biopsy for Head and Neck Cancer -- Approaches to Supportive Care -- Intensity-Modulated Radiation Therapy for Head and Neck Cancer -- Principles of Systemic Chemotherapy for Squamous Cell Head and Neck Cancer -- Molecular Targeted Therapies in Head and Neck Cancer -- Phase I Study Methodology in Head and Neck Oncology -- Evidence-Based Head and Neck Oncology: Principles and Pitfalls -- Programs of Organ and Function Preservation -- Multidisciplinary Approach of Unresectable Head and Neck Cancer -- Laser Endoscopic Treatment -- Multidisciplinary Management of Skull Base and Superstructure Tumors. Multidisciplinary Management of Oral Cavity and Maxillary Sinus Cancers -- Cancers of the Larynx: Tis, T1, T2 Evaluation and Management -- Multidisciplinary Management of Oropharynx Carcinomas -- Multidisciplinary Management of Hypopharyngeal Carcinoma -- Cancers of the Larynx: Tis, T1, T2 Evaluation and Management -- Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers -- Principles and New Approaches in Surgical Reconstruction -- Multidisciplinary Treatment of the Neck -- Postoperative Management of High-Risk Resectable Head and Neck Cancer -- Management of Salivary Gland Cancer -- Head and Neck Melanoma -- Cervical Lymph Node Metastases of Squamous Cell Carcinoma from an Unknown Primary Site -- Management of Thyroid and Parathyroid Cancers -- Head and Neck Paragangliomas --Treatment of the Elderly Head and Neck Cancer Patient -- Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity -- Proton Beam Therapy for Head and Neck Cancer -- Normal Tissue Complications and Protection in Head and Neck Cancer Patients -- Rehabilitation of Heavily Treated Head and Neck Cancer Patients -- Salvage Therapy in Head and Neck Cancer Patients -- Systemic Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck -- Best Supportive Care for Palliative Treatment -- Quality of Life in Head and Neck Cancer Patients -- Quality Assurance of Clinical Trials in the Management of Cancer in the Head and Neck.
  • 2013 ClinicalKey
    "Part of the popular Foundations in Diagnostic Pathology Series, Head and Neck Pathology delivers vital diagnostic guidance in a compact, high-yield format. Concise and easy to use, this pathology reference offers a practical, well-organized approach to evaluating a wide range of specimens in both head and neck and related endocrine pathology. Easily review normal histology before examining abnormal findings so you can avoid false positives. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Apply the latest diagnostic criteria for all of the most commonly seen neoplastic and non-neoplastic conditions of the larynx, hypopharynx, and trachea; nasal cavity, paranasal sinuses, and nasopharynx; oral cavity and oropharynx; salivary glands; ear; and temporal bone. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Quickly reference key information with convenient, at-a-glance clinical and pathologic boxes throughout."--Summary of the editor.
  • Specific Challenges in Optimizing Health Care for Cancer Survivors -- What Is Quality Health Care for Cancer Survivors? -- Managing Symptoms over Time -- Health Behaviors and Wellness -- Rehabilitation in the Context of Cancer Survivorship -- Long-Term Psychological Well-Being: Strategies for Assessment and Intervention -- Disparities in Care for Cancer Survivors -- Cancer Survivorship Plans: A Paradigm Shift in the Delivery of Quality Cancer Care -- Optimizing Health: Primary Care -- Optimizing Health: Oncology Care -- Optimizing Survivorship Care: Academic and Community Clinic Models -- The Final Phase of Cancer Survivorship: End-of-Life Care -- Building a Critical Mass of Health-Care Providers, Administrators, and Services for Cancer Survivors -- Epidemiology of Cancer Recurrence, Second Primary Cancer, and Comorbidity Among Cancer Survivors -- Health Economics and Cancer Survivorship -- Human Factors Engineering: Targeting Systems for Change -- Cancer Survivorship and National Health Reform -- Quality Health Care for Cancer Survivors.
  • The Nature of cancer and its psychosocial challenges -- Why work with couples? -- Assessing the couple's adjustment to cancer -- Integrating tasks of illness into the couple's daily routine -- Building cognitive coping skills -- Communicating support -- Expanding the couple's coping skills -- Enhancing sexuality and body image -- Helping children to cope when a mother has cancer -- Living with cancer after treatment ends.
  • B Cell Growth, Differentiation and Malignancies / Jianguo Tao and Chih-Chi Andrew Hu -- Follicular Lymphoma: Recent Advances / Alyssa Bouska, SharathKumar Bagvati, Javeed Iqbal, Basem M. William and Wing C. Chan -- Chronic Lymphocytic Leukemia: From Pathobiology to Targeted Therapy / Javier Pinilla-Ibarz and Chih-Chi Andrew Hu -- Genetic and Environmental Determinants in Multiple Myeloma: Implications for Therapy / Kenneth H. Shain and William S. Dalton -- EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly / Jorge J. Castillo -- HIV and Lymphoma / Lubomir Sokol and Brady E. Betran -- Molecular Biology of Mantle Cell Lymphoma / Bijal Shah, Peter Martin, Jianguo Tao and Eduardo M. Sotomayor -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Inflammatory, Autoimmune or Immunologic Disorders / Ling Zhang and Jianguo Tao -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Infection Diseases / Ling Zhang and Roger Klein -- Hodgkin Lymphoma: From Molecular Pathogenesis to Targeted Therapy / Ádám Jóna, Árpád Illés and Anas Younes -- Myelodysplastic Syndromes / Grant E. Nybakken and Adam Bagg -- Chronic Myeloproliferative Disorders:From Molecular Pathogenesis to Targeted Therapy / Richard A. Walgren and Josef Prchal -- Chronic Myeloid Leukemia / Kapil Bhalla, Celalettin Ustun and Warren Fiskus -- Novel Targeted Therapeutics for Acute Myeloid Leukemia / Vu Duong and Jeffrey Lancet -- Novel Targeted Therapeutics for Peripheral T-Cell Lymphoma / Owen O. Connor, Salvia Jain and Jasmine Zain -- Large Granular Lymphocyte Leukemia - From Molecular Pathogenesis to Targeted Therapy / Mithun Vinod Shah and Thomas P. Loughran Jr. -- Epigenetic Regulation and Therapy in Lymphoid Malignancies / Yizhuo Zhang, Shanqi Guo and Haifeng Zhao.
  • Also available: Print – 2006
  • Also available: Print – 2011
    Part 1. Background: Biology, Physiology and Pharmacology -- Part 2. The Colony-Stimulating Factors -- Part 3. The Erythroid-Stimulating Agents -- Part 4. The Thrombopoietic Agents -- Part 5. Special Considerations.
  • Anatomy -- Surgical instrument and dissection technique -- Surgical procedures -- Approaches to the caudate lobe -- Classification of caudate lobe resection -- Retrograde resection of caudate lobe -- Measures for safe resection of caudate lobe -- Laparoscopic resection of the caudate lobe.
  • Etilology and epidemiology of hepatocellular carcinoma / Jawad Ahmad and Mordechai Rabinovitz -- Molecular mechanisms of hepatocellular carcinoma: insights to therapy / Marie C. DeFrances and George K. Michalopoulos -- Clinical features and diagnostic evaluation of hepatocellular carcinoma / David A. Sass and Kapil B. Chopra -- Pathologic aspects of hepatocellular tumors / Hale Kirimlioglu, Anthony J. Demetris, and Michael A. Nalesnik -- Use of imaging techniques to screen for hepatocellular carcinoma / Michael P. Federle -- Radiologic evaluation of hepatocellular carcinoma / Michael P. Federle and Michael J. Payne -- Percutaneous ethanol and acetic acid ablation of hepatocellular carcinoma / Vibhu Kapoor and F. Leland Thaete -- Radiofrequency ablation of hepatocellular carcinoma / Martin Goodman and David A. Geller -- Hepatic resection for hepatocellular carcinoma -- Katsuhiko Yanaga ... [et al.] -- Liver transplantation for hepatocellular carcinoma / Andrew Bonham ... [et al.] -- Interventional radiology techniques for intra-arterial chemo-embolization / Nikhil B. Amesur, Albert B. Zajko, and Philip D. Orons -- Medical therapy of hepatocellular carcinoma / Brian I. Carr -- Radiation therapy for hepatocellular carcinoma / Andrew S. Kennedy -- Putting it all together: practical guidelines and considerations for physicians / Brian I. Carr, J. Wallis Marsh, and David A. Geller.
  • Epidemiology of hepatocellular carcinoma -- Environmental carcinogens and risk for human liver cancer -- Primary liver cancer: chemical carcinogenesis -- Molecular mechanisms of hepatocellular carcinoma: insights to therapy -- Genomic profiling of human hepatocellular carcinoma -- Pathologic aspects of hepatocellular tumors -- Hepatocellular carcinoma associated with hepatitis B virus -- Hepatitis C and hepatocellular carcinoma -- Metabolic disease and hepatocellular carcinoma -- Clinical features and a clinician's diagnostic approach to hepatocellular carcinoma -- Screening and biomarkers for hepatocellular carcinoma -- Use of imaging techniques to screen for hepatocellular carcinoma -- MRI for detection and evaluation of hepatocellular carcinoma -- Ultrasound of hepatocellular carcinoma: the important contribution of contrast enhancement -- Percutaneous ethanol injection -- Radiofrequency ablation of hepatocellular carcinoma -- Resection of hepatocellular carcinoma -- Liver transplantation for hepatocellular carcinoma -- Living donor liver transplantation for hepatocellular carcinoma -- Medical therapy of HCC -- Percutaneous interventional technique for intra-arterial chemoembolization -- Molecular targeted therapies for HCC -- Radiation therapy for hepatocellular carcinoma -- Psychosocial issues in hepatocellular carcinoma -- Putting it all together.
  • Epidemiology and pathogenesis of hepatocellular carcinoma -- Biology of hepatocellular carcinoma -- Hepatocellular cancer: pathologic considerations -- Screening program in high-risk populations -- Staging of hepatocellular carcinoma -- Multidisciplinary care of the hepatocellular carcinoma patient -- Evidence-based guidelines for treatment of hepatocellular carcinoma in Japan -- Hepatocellular carcinoma arising in the non-viral, non-alcoholic liver -- Liver resection for hepatocellular carcinoma -- Ultrasound-guided liver resection for hepatocellular carcinoma -- Portal vein embolization prior to resection -- Laparoscopic liver resection for HCC: a European perspective -- Laparoscopic liver surgery for the management of hepatocellular carcinoma: the American perspective -- Liver transplant for hepatocellular carcinoma -- Vascular resection for hepatocellular carcinoma -- Radiofrequency ablation for hepatocellular carcinoma -- Microwave ablation and hepatocellular carcinoma -- Transarterial chemoembolization -- Chemoembolization with drug-eluting beads -- Yttrium-90 radioembolotherapy for hepatocellular carcinoma -- Cytotoxic chemotherapy and endocrine therapy for hepatocellular carcinoma -- Targeted therapies for hepatocellular carcinoma -- The future: combination systemic therapy for hepatocellular carcinoma -- Follow-up and salvage therapy for recurrent hepatocellular carcinoma.
  • Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6percent, however patients with a familial risk (with two or more first or second degree relatives) make up 20percent of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
  • Histologic classification of high-grade gliomas / Richard A. Prayson -- Molecular classifications / Gregory N. Fuller-- Pediatric high-grade glioma / Bruce H. Cohen -- Adult high-grade glioma / Nicholas Butowski, Susan Chang -- Computerized tomography / Manzoor Ahmed, Thomas J. Masaryk -- Magnetic resonance imaging / Paul M. Ruggieri -- Magnetic resonance spectroscopy / G. Evren Keles, Soonmee Cha, Mitchell S. Berger -- Imaging tumor biology: physiological and molecular insights / Timothy P. L. Roberts, Andrea Kassner -- Nuclear imaging of gliomas / Alexander M. Spence ... [et al.] -- Magnetoencephalography / Michael P. Steinmetz, Jurgen Luders, Edward C. Benzel -- General considerations / Glen H. J. Stevens -- Surgical techniques / Gene H. Barnett -- Radiation therapy / Hiral K. Shah, Minesh P. Mehta -- Brachytherapy / Marcus L. Ware, P. K. Sneed, Michael W. McDermot -- Radiosurgery / John H. Suh, Gene H. Barnett -- Chemotherapy / Manmeet Singh Ahluwalia, David M. Peereboom -- Nursing considerations / Kathleen Lupica, Gail Ditz -- Convection-enhanced delivery / Andrew A. Kanner -- Immunotoxins for glioma therapy / Syed Rafat Husain, Raj K. Puri -- Small molecule agents / Michael Vogelbaum, Tina Thomas -- Cytokine immuno-gene therapy for malignant brain tumors / Roberta P. Glick ... [et al.] -- Monoclonal antibodies / Abraham Boskovitz ... [et al.] -- Clinical trials of oncolytic viruses for gliomas / E. Antonio Chiocca, M. L. Lamfers -- Biological modifiers / Alexander Mason, Steven Toms, Aleck Hercbergs -- Gene therapy / Maciej S. Lesniak, Alessandro Olivi -- Boron neutron capture therapy of brain tumors: current status and future prospects / Rolf F. Barth ... [et al.] -- Photodynamic therapy / Bhadrakant Kavar, Andrew H. Kaye.
  • This is a multi-author book on hilar cholangiocarcinoma, written by an international team of world-renowned experts covering topics in their respective areas of expertise. There are altogether 71 authors from 14 countries/regions, mainly Argentina, Australia, China, Germany, Italy, Japan, Korea, Malaysia, Thailand, the Netherlands, the United Kingdom and the United States of America.This book aims to provide an up-to-date, fully referenced text that is as succinct as possible, but as comprehensive as necessary, addressing all topics in hilar cholangiocarcinoma.
  • The histopathologic interpretation of melanocytic neoplasms is probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions that histopathologists might encounter. Each case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist both general pathologists and dermatopathologists in making an accurate diagnosis applicable to their daily practice, and one that can be understood by clinicians. They achieve this by providing criteria that can serve as a sound basis for an unequivocal diagnosis in most cases. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
  • K-acetylation and its enzymes: overview and new developments / Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang.-- Biology of HDAC in cancer: the nuclear and epigenetic components / Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayer, Christian Seiser.-- Deacetylation of nonhistone proteins by HDACs and the implications in cancer / Lirong Peng, Edward Seto.-- Biology and therapeutic implications of HDACs in the heart / Timothy A. McKinsey.-- HDACs in skeletal muscle remodeling and neuromuscular disease / Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao.-- Rationale for HDAC inhibitor therapy in autoimmunity and trasplantation / Wayne W. Hancock.-- Role of mammalian sirtuins in the regulation of metabolism, aging, and longevity / Akiko Satoh, Liana Stein, Shin Imai.-- Mictochondrial sirtuins in the regulation of mictochondrial activity and metabolic adaption / David B. Lombard, Daniel X. Tishkoff, Jianjun Bao.-- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance / Debra Toiber, Carlos Sebastian, Raul Mostoslavsky.-- Structural biology of human netal-dependent histone deacetylases / Matthieu Schapira.-- Sirtuin modulators / Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov.
  • Histone deacetylase 1 / Dominique Meunier and Christian Seiser -- Biochemistry of multiprotein HDAC complexes / Alejandro Vaquero, Michael Scher, and Danny Reinberg -- The biology of HDAC3 / Edward Seto -- The biology of HDAC8, a unique class I histone deacetylase / David Waltregny and Vincent Castronovo -- Regulation of muscle gene expression by histone deacetylases / Timothy A. McKinsey and Eric N. Olson -- The class IIA histone deacetylases: functions and regulation / Herbert G. Kasler and Eric Verdin -- Histone deacetylases in the response to misfolded proteins / J. Andrew McKee and Tso-Pang Yao -- Evolution of sirtuins from archaea to vertebrates / Roy A. Frye -- Structure of the Sir2 family of NAD+-dependent histone/protein deacetylases / Kehao Zhao and Ronen Marmorstein -- The enzymology of Sir2 proteins / Margie T. Borra and John M. Denu -- The class III protein deacetylases: homologs of yeast Sir2P / Bjoern Schwer ... [et al.] -- HDAC inhibitors: discovery, development, and clinical impacts / Akihiro Ito, Norikazu Nishino, and Mitsuaki Yoshida -- Cell cycle targets of histone deacetylase inhibitors / Brian Gabrielli -- HDAC inhibitors: an emerging anticancer therapeutic strategy / Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja.
  • This bookprovides an easily comprehensible and practicable framework for standardised histopathology reports in surgical cancer. It details the gross description, histological classification, tumor differentiation, extent of local tumor spread, involvement of lymphovascular channels, lymph nodes and excision margins of the common carcinomas and also summarises non-carcinomatous malignancies. The 7th edition TNM and WHO classifications of cancers are incorporated, with comments on any associated pathology, diagnostic clues and prognostic criteria. Staging information is supplemented visually by line diagrams. Each chapter has a more formal introductory paragraph than in the previous edition,giving epidemiological, clinical, investigative and treatment summary details, and chapter references are updated; specimen type notes new clinical procedures. Other pathology includes updated immunophenotypic expression with use of newantibodies and molecular techniques. The impact of these ancillary investigations on diagnosis, and as biomarkers of prognosis and prediction of response to treatment is summarised. The effect of adjuvant treatments on cancers is also noted. Experience based clues are given throughout as aids to tumor typing, grading, staging and gauging prognosis and response to treatment. The key information in this book equips the pathologist to produce high quality, clinically appropriate histopathology reports, and to participate in contemporary multidisciplinary team management of patients with surgical cancer. Histopathology Reporting: Guidelines for Surgical Cancer, Third Edition is invaluable for trainee and consultant diagnostic histopathologists all over the world.
  • This book examines in detail the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the management appropriate in special clinical circumstances, including in the elderly, pregnant women, and those with lymphocyte-predominant disease. Careful attention is devoted to the emerging individually tailored treatment strategies that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The second edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by the key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma. .
  • Also available: Print – 2007
  • Also available: Print – 2006
  • Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.
  • Also available: Print – 2008
  • Also available: Print – 2009
  • Also available: Print – 2010
    Household Use of Solid Fuels -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- High-temperature Frying -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • HPV and cancer 2012
    "HPV and Cancer" is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes.
  • Infection and Cervical Cancer: An Old Fact with a Recent Solution / Lutz Gissman -- Human Papillomavirus: Natural History of a Viral Infection in the Genesis of a Cancer / Franco Borruto and Ciro Comparetto -- The Immunobiology of Human Papillomavirus Associated Oncogenesis / Peter L. Stern and Mark H. Einstein -- The Epidemiology of Cervical Cancer / Xavier Castellsagué, Laia Bruni, Laia Alemany, Mireia Diaz and Silvia de Sanjosé, et al. -- The Basic Elements of a Correct Diagnosis: From Cytohistopathology to Screening / Franco Borruto and Ciro Comparetto -- Human Papillomavirus DNA Testing: What, How, and When / Ciro Comparetto and Franco Borruto -- Colposcopic Appearance of HPV Infection / Santiago Dexeus, Montserrat Cararach and Damian Dexeus -- Multiple Aspects of Human Papillomavirus Infections / Franco Borruto and Ciro Comparetto -- Prevention of HPV-Associated Diseases in the United States / Diane M. Harper -- Immunogenicity, Efficacy, Effectiveness and Overall Impact of HPV Vaccines / Matti Lehtinen, Pekka Nieminen, Dan Apter, Proscowa Namujju and Kari Natunen, et al. -- Treatment, Follow-up, and Prevention of Papillomavirus Infection and Cervical Cancer / Franco Borruto and Ciro Comparetto -- Therapeutic Vaccines for HPV Infection / Margaret Stanley -- Perspectives on Therapeutic HPV Vaccines: Where Are We Now? / Connie Wang, Barbara Ma, Alexander Chen, Chien-Fu Hung and T. C. Wu.
  • Anatomical sites and subsites of head and neck cancer -- Epidemiology of oral HPV infection and HPV-associated head and neck cancer -- Frequent behavioural questions with an HPV-positive malignancy of the head and neck -- The molecular biology of HPV-related head and neck cancer -- The diagnosis of HPV-related head and neck squamous cell carcinoma: Recognition of its microscopic appearance and the use of ancillary detection assays -- Clinical management of HPV-related oropharyngeal cancer -- The role of vaccines for HPV-related head and neck cancers -- The care of the HPV-negative head and neck cancer patient: Presentation, prognosis, treatment. .
  • Molecular epidemiology of human papillomavirus infection -- / Gillison, M.L -- Molecular pathogenesis of the human papillomavirus / Mao, C.-P., Wu, T.-C -- Human papillomavirus vaccines / Roden, R., Hung, C.-F., Monie, A., Wu, T.-C -- Hepatitis C virus genetics and the discovery of mechanism based inhibitors of the Ns3/4A protease and NS5B polymerase / LaFemina, R.L -- Role of the hepatitis B virus in hepatocellular carcinoma / Toh, S.-T., Lee, C.G -- Carcinogenesis induced by hepatitis B virus / Cougot, D., Buendia, M.-A., Neuveut, C -- Disease and pathogenesis associated with Epstein-Barr virus / Ambinder, R.F -- The biology and molecular biology underlying Epstein-Barr virus oncogenesis / Martin, H.J., Hayward, S.D -- Kaposi-sarcoma-associated herpesvirus clinical diseases and viral pathogenesis / Damania, B., Dittmer, D.P. -- Molecular biology of human herpesvirus 8 neoplasia / Chaudhary, P.M., Nicholas, J -- Human cancer viruses. Human T cell leukemia virus type 1 and 2: mechanisms of pathogenesis / Arnold, J., Green, P.L -- Chromosomal instability and human T cell leukemia virus 1 transformation / Chi, Y.-H., Jeang, K.-T.
  • Also available: Print – 2011
    Pt. 1. Multistep models -- pt. 2. Prostate cancer/stem cells -- pt. 3. Breast cancer/stem cells -- pt. 4. Multistep/genes.
  • 1. Human Papillomavirus (HPV) infection -- 2. Studies of cancer in humans -- 3. Studies of animal papillomaviruses -- 4. Molecular mchanisms of HPV-induced carcinogenesis -- 5. Summary of data reported and evaluation -- 6. References
  • Association between cancer and "acid mucopolysaccharides" : an old concept comes of age, finally -- Hyaluronan-CD44 interactions and chemoresistance in cancer cells -- Growth factor regulation of hyaluronan deposition in malignancies -- Hyaluronan binding protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development -- CD44 meets Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of Merlin -- Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression -- Adhesion and penetration : two sides of CD44 signal transduction cascades in the context of cancer cell metastasis -- Involvement of CD44, a molecule with a thousand faces, in cancer dissemination -- RHAMM/HMMR : an itinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation -- Altered hyaluronan biosynthesis in cancer progression -- Hyaluronidase : both a tumor promoter and suppressor -- The hyaluronidases in cancer biology -- Hyaluronan fragments : informational polymers commandeered by cancers -- Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan -- The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression -- Hyaluronan synthesis and turnover in prostate cancer -- Role of hyaluronan in melanoma progression -- Role of hyaluronan metabolism in the initiation, invasion, and metastasis of breast cancer -- Clinical use of hyaluronidase in combination cancer chemotherapy : a historic perspective -- Exploring the hyaluronan:CD44 interaction for cancer therapy -- Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that cause contagious respiratory tract cancers.
  • Ch. 1. Emerging roles for hyaluronidase in cancer metastasis and therapy -- Ch. 2. Targeting hyaluronic acid family for cancer chemoprevention and therapy -- Ch. 3. Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression -- Ch. 4. Hyaluronan synthases posttranslational regulation in cancer -- Ch.4. Hyaluronan synthases posttranslational regulation in cancer -- Ch. 5. Hyaluronan-coated extraellular vesicles, a novel link between hyaluronan and cancer -- Ch.6.Hyaluronan in the healthy and malignant hematopoietic microenvironment -- Ch. 7. Hyaluronan regulation of endothelial barrier function in cancer -- Ch. 8. HAS2 and CD44 in breast tumorigenesis -- Ch. 9. CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals -- Ch. 10. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression -- Ch. 11. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer -- Ch.12. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors -- Ch. 13. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance -- Index.
  • Hypoxia and breast cancer metastasis / Luana Schito and Gregg L. Semenza -- Hypoxia and DNA damage response / Monica M. Olcina and Ester M. Hammond -- Emerging roles of non-coding RNAs in the hypoxic response / Mircea Ivan ... [et al.] -- Hypoxia and reactive oxygen species / Agnes Gorlach -- Hypoxia and gene expression / Maria Carla Bosco and Luigi Varesio -- Carbonic anhydrase IX : from biology to therapy / Silvia Pastorekova and Claudiu T. Supuran -- Imaging the hypoxic tumor microenvironment in preclinical models / Mary-Keara Boss, Gregory M. Palmer and Mark W. Dewhirst -- Clinical imaging of hypoxia / Michael R. Horsman ... [et al.] -- Hypoxia, metastasis, and antiangiogenic therapies / Dietmar W. Siemann, Yao Dai and Michael R. Horsman -- Unfolded protein response and therapeutic opportunities / Carly M. Sayers ... [et al.] -- Small molecules targeting the VHL/hypoxic phenotype / Raymond J. Louie ... [et al.] -- Hypoxia and radiation therapy / Marianne Nordsmark ... [et al.] -- Prodrug strategies for targeting tumour hypoxia / William R. Wilson ... [et al.] -- Exploiting "Hif addiction" for cancer therapy / Nicole D. Fer and Annamaria Rapisarda -- Clinical exploitation of hypoxia / Geoff S. Higgins and Adrian L. Harris.
  • The epidermal growth factor receptor (EGFR) is essential to multiple physiologic and neoplastic processes via signaling by its tyrosine kinase domain and subsequent activation of transcription factors. We identified a novel splice variant of the EGFR called mini-LEEK (mLEEK) which represents a deletion of exons 2-22 but maintains the open reading frame and generates a novel glycine codon at the junction. This variant deletes the extracytoplasmic domain, transmembrane region, and most of the tyrosine kinase domain of the EGFR. mLEEK is localized to the nucleus in most cells and since it contains a previously characterized strong transactivation domain, we hypothesized that mLEEK functions to regulate transcription. Microarray studies revealed upregulation of several molecular chaperone proteins, including GRP78 (also known as BiP) and GRP94, in response to mLEEK expression. Overexpression of mLEEK resulted in increased transcription from GRP78 and GRP94 luciferase reporter plasmids as well as an increase in endogenous GRP78 and GRP94 protein levels, suggesting a direct effect on transcription. Furthermore, mLEEK utilizes the cis-regulatory ER stress response element (ERSE) found in both the GRP78 and GRP94 promoters to activate transcription as mutation of the ERSE elements in the GRP78 promoter abolishes the activation of transcription by mLEEK. Chromatin immunoprecipitation experiments demonstrate that mLEEK physically interacts in a complex with the ERSE-containing region of the GRP78 promoter. Additionally, mLEEK co-precipitates with ATF6, a transcription factor known to be part of the ERSE-mediated activation of chaperones. Molecular chaperone transcription is induced as a downstream effector of the unfolded protein response (UPR). The UPR is a mechanism that increases the cellular capacity for protein folding. Cellular demands for protein folding increase upon physiological conditions that create endoplasmic reticulum (ER) stress. Interestingly, mLEEK specifically upregulates molecular chaperones required for the UPR and does not activate other arms of the UPR. Splicing of XBP1 precursor mRNA, which is uniquely triggered upon ER stress, was reduced in cells overexpressing mLEEK. Another molecular readout for UPR induction is the activation of CHOP transcription. Cells overexpressing mLEEK demonstrated reduced activation of CHOP transcription in the presence of ER stress inducing agents. Moreover, knockdown of mLEEK results in enhanced sensitivity to ER stress. Collectively, these data suggest that expression of mLEEK and the subsequent upregulation molecular chaperones primes cells to accommodate the increased need for protein folding upon ER stress and prevents induction of the UPR. mLEEK is also essential for cell viability, as mLEEK knockdown lead to reduced viability and increased activation of caspases. We found that mLEEK is present at the RNA and protein level in a high percentage of tumors relative to normal tissue. Preliminary data suggest that mLEEK expression does not lead to transformation of NIH3T3 cells. The potential contribution of mLEEK to tumorigenesis will be revisited in the future using knockdown strategies that were subsequently developed. Other preliminary data have shown that mLEEK is secreted into the media and taken up by neighboring cells, leading to increased GRP94 transcription in recipient cells. Collectively, our work describes the discovery and characterization of a novel EGFR variant. These findings reveal an unexpected function for an EGFR variant and represent a new mechanism for the upregulation of molecular chaperones required for the UPR that could be exploited for therapeutic purposes. Our findings also suggest a potential role for mLEEK in cancer and a novel method of cell communication mediated by a secreted protein. These possibilities await future studies.
  • "Advances in computed tomography have made it possible to detect small lung cancers, which has changed lung cancer surgery from lobectomy to a lesser lobar resection such as a segmentectomy or wedge resection. Although wedge resection is a simple procedure, it has a higher risk of hilar lymph node or surgical margin recurrence than does a lobectomy. On the other hand, segmentectomy is a well-known curative surgery for small lung cancers. It is difficult to perform accurately, however, because of its anatomical complexity, which makes surgeons hesitant to use it. Illustrated Anatomical Segmentectomy for Lung Cancer provides readers a detailed explanation of segmentectomy with numerous easy-to-understand color illustrations showing the precise segmental anatomies for each pattern of the procedure. To better illustrate an accurate anatomical segmentectomy, the text shows details of anatomy during the procedure. Up to 25 patterns can be involved, each of which is shown in approximately 10 illustrations."--publisher's website
  • Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation.
  • "This book provides complete descriptions of the techniques involved in medical image processing, using sufficient descriptions and practical references. Chapters cover topics of deformable registration, segmentation, image reconstruction, and integration of these practices into the radiation therapy environment. The four sections provide an overview of the image segmentation and reconstruction techniques using image processing across all modalities, and applications of these approaches in radiation therapy. The book also addresses the applications of registration, segmentation, and image reconstruction for radiation therapy, including adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results"--Provided by publisher.
  • Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few), and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the books Foreword: The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics. This book is an outstanding contribution to the literature and will become a must read for all physicians who are interested in Interventional Oncology.
  • "Preface This book presents key image-guided radiation treatment (IGRT) technologies for external beam radiotherapy and caps a multidecade phase of technology development in the realm of conformal, customized radiation treatment. This development phase has been somewhat brief and vigorous, with new IGRT innovations such as increased image fidelity and adaptive radiotherapy continuing through the present day. IGRT had been in development in earnest since the early 1990s as a desired companion to intensity-modulated radiation treatment (IMRT). It was known at the time that beam-intensity modulation would be proven to enable beamlets of radiation dose to be formed and delivered to give highly conformal treatment to target volumes, while at the same time providing avoidance of even nearby normal structures. IMRT was being developed with pathways that were based on particular technological features of each vendor's designs for their multileaf collimators (MLCs) and linear accelerators, e.g., leaf design (width, height, focus, speed, etc.), dose rate control, error checking, and gantry motion control. In a previous decade, the 1980s into the mid-1990s, three-dimensional conformal radiation treatment (3D-CRT) had been developed such that for the first time, using static pretreatment 3D images from computed tomography (CT), anatomical volumes could be identified and segmented for the target, normal structures, and the external contour. As 3D-CRT and IMRT technologies developed, it was recognized that confirming "correct" treatment geometry for every individual fraction might be important, since daily variations in treatment position and the locations of internal structures would lead to blurring (degradation) of the cumulative dose distribution"--Provided by publisher.
  • Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.
  • Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized on US, CT or MR images. This atlas, which encompasses both the imaging and the pathology of pancreatic neoplasms, will therefore be invaluable in enabling radiologists and sonographers to understand the underlying pathology and in allowing pancreatic pathologists to understand the imaging translation. The emphasis in the atlas is very much on the pathological and imaging appearances, with most of the text concentrated at the beginning of the chapters. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and uncommon pancreatic neoplasms, including ductal adenocarcinoma, neuroendocrine neoplasms, intraductal papillary mucinous neoplasms, cystic neoplasms, metastases and lymphoma.
  • This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy, and chemotherapy. Normal and pathological findings are displayed in detailed MR images that illustrate the potential modifications due to treatment. Particular emphasis is placed on characteristic appearances on the newer functional MR imaging techniques, including MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. These techniques are revolutionizing neuroradiology by going beyond the demonstration of macroscopic alterations to the depiction of preceding metabolic changes at the cellular and subcellular level, thereby allowing earlier and more specific diagnosis. A key section comprising some 40 clinical cases and more than 500 illustrations offers an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, radiotherapists, and medical oncologists.
  • Part I. Introduction to oncologic imaging -- Part II. Bone and soft tissue tumors -- Part III. CNS tumors -- Part IV. Lung cancer -- Part V. Head and neck cancer -- Part VI. Lymphomas -- Part VII. Gynecologic cancer -- Part VIII. Breast cancer -- Part IX. Gastrointestinal cancer -- Part X. Neuroendocrine tumors -- Part XI. Urogenital cancer -- Part XII. Melanoma.
  • Imaging in oncology 2008
    Also available: Print – 2008
    Anatomic, physiologic and metabolic imaging in neuro-oncology / Sanjeev Chawla, Harish Poptani, and Elias R. Melhem -- Imaging of spinal tumors / Izlem Izbudak ... [et al.] -- PET imaging of brain tumors / Alan J. Fischman -- Extracranial head and neck neoplasms: role of imaging / Myria Petrou and Suresh K. Mukherji -- Imaging of thoracic malignancies / Subba R. Digumarthy and Suzanne L. Aquino -- Imaging of mediastinal tumors / Scott Moore, Hetal Dave-Verma, and Ajay Singh -- Imaging cardiac tumors / Mannudeep K. Kalra and Suhny Abbara -- Diagnostic imaging and image-guided interventions of hepatobiliary malignancies / Unni Udayasankar ... [et al.] -- Recent advances in imaging of pancreatic neoplasms / Chad B. Rabinowitz, Hima B. Prabhakar, and Dushyant V. Sahani -- Imaging of colorectal carcinoma / Jorge A. Soto -- Imaging of primary malignant tumors of peritoneal and retroperitoneal origin / J. Louis Hinshaw and Perry J. Pickhardt -- Imaging of urinary tract tumors / Michael A. Blake and Mannudeep K. Kalra -- Current status of imaging for adrenal malignant involvement / Michael A. Blake and Mannudeep K. Kalra -- Recent advances in imaging of male reproductive tract malignancies / Jurgen J. Fütterer and J. Roan Spermon -- Imaging of malignant skeletal tumors / Jay Pahade, Aarti Sekhar, and Sanjay K. Shetty -- Radiology of soft tissue tumors including melanoma / M.J. Shelly, P.J. MacMahon, and S. Eustace -- Reticuloendothelium malignancy: current role of imaging / Sunit Sebastian and Brian C. Lucey -- Pediatric malignancies: synopsis of current imaging techniques / Sabah Servaes ... [et al.] -- Interventional radiology in oncology / O.J. O'Connor, J. M. Buckley, and M. M. Maher -- Breast tumor imaging / Deirdre Coll
  • Epidemiology, histologic classification, and clinical course of brain tumors -- Imaging modalities in brain tumors -- Molecular abnormalities in gliomas -- The clinical applicability of fMRI and DTI in patients with brain tumors -- Low-grade gliomas -- High-grade gliomas -- Pineal tumors -- Embryonal tumors -- Tumors of the cranial nerves -- Meningeal tumors -- Central nervous lymphomas and hemopoietic neoplasms -- Masses of the sellar and junxtasellar region -- Brain metastasis -- Scintigraphy for brain tumors.
  • This book is devoted to the diagnosis and treatment of male breast pathology. It provides a comprehensive overview of current strategies for the diagnosis of breast malignancies in men, with a focus on imaging modalities. Ultrasound of male breast abnormalities is discussed in particular depth, but the roles of other imaging techniques, genetic tests, and interventional diagnostic modalities are also carefully covered. Special attention is paid to differential diagnosis of malignant and benign lesions, and the most important benign breast diseases are described and illustrated with high-quality images. A special chapter analyzes treatment strategy in men with breast malignancies and principles of follow-up after breast surgery. Individual chapters are also devoted to the diagnosis of recurrent cancer and cancer metastases. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.
  • Also available: Print – 2006
    Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Benign fibrous and fibrohistiocytic tumors -- Malignant fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic lesions -- Synovial tumors -- Extraskeletal osseous and cartilaginous lesions -- Tumors of uncertain histogenesis -- Masses which may mimic soft tissue tumors -- Compartmental anatomy.
  • Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic tumors -- Synovial tumors -- Extraskeletal osseous and cartilagenous tumors -- Tumors of uncertain histogenesis -- Superficial soft tissues masses -- Mass which may mimic soft tissue tumors -- Compartmental anatomy.
  • Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • Immuno-Oncology 2015
    Immunotherapies in early and advanced renal cell cancer / Kasenda, B., Larkin, J., Gore, M. -- Immunotherapy of brain tumors / Dutoit, V., Migliorini, D., Walker, P.R., Dietrich, P.-Y. -- Immunotherapy of melanoma / Snyder, A., Zamarin, D., Wolchok, J.D. -- Immunotherapy of breast cancer / Criscitiello, C., Curigliano, G. -- Current developments in actively personalized cancer vaccination with a focus on RNA as the drug format / Diken, M., Kreiter, S., Kloke, B., Sahin, U. -- Immune checkpoint inhibitors / Haanen, J.B.A.G., Robert, C. -- Radiotherapy and immunotherapy : improving cancer treatment through synergy / Reynders, K., De Ruysscher, D. -- Combinations therapies / Reinmuth, N., Reck, M. -- Promise of immunotherapy in lung cancer / Shanker, A., Dikov, M.M., Carbone, D.P. -- T cell engineering / Pircher, M., Schirrmann, T., Petrausch, U.
  • Immunotherapy of cancer 2015
  • Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • Obesity and Cancer in Appalachia -- Disparities in Cancer Outcomes A UK Perspective -- Behavioral Differences Leading to Disparities in Energy Balance and Cancer -- Impact of obesity, race, and ethnicity on cancer survivorship -- The biology of aging: Role in cancer, metabolic dysfunction and health disparities -- Energy Balance and Multiple Myeloma in African Americans -- Single Nucleotide Polymorphisms in Obesity and Inflammatory Genes in African Americans with Colorectal Cancer -- Ethnic Differences in Insulin Resistance as a mediator of Cancer Disparities -- Role of ethnic differences in mediators of energy balance -- Community-Based Strategies to Alter Energy Balance in Underserved Breast Cancer Survivors -- The role of policy in reducing inflammation -- Cancer Prevention through Policy Interventions that Alter Childhood Disparities in Energy.
  • Also available: Print – 2013
    Novel antineoplastics targeting genetic changes in colorectal cancer / Jamal Joudeh...[et al.] -- Update on clinical trials: genetic targets in breast cancer / Bora Lim, Leah V. Cream, Harold A. Harvey -- Impace of genetic targets on cancer therapy in esophagogastric cancer / Yixing Jiang -- Impact of genetic targets on cancer therapy: hapatocellular cancer / Osama Hamed...[et al.] -- Toward the goal of personalizaed therapy in pancreatic cancer by targeting the molecular phenotype / Nelson S. Yee -- Impact of genetic markers on treatment of non-small cell lung cancer / Nicholas Lamparella, Amit Barochia, Salah Almokadem -- Impact of genetic targets on therapy in head and neck squamous cell carcinoma / Irina Chaikhoutdinov, David Goldenberg -- Tyrosine kinase targeted treatment of chronic myelogenous leukemia and other myeloproliferative neoplasms / Ajit Bisen, David F. Claxton -- Targeted tehrapy of multiple myeloma / Nathan G. Dolloff, Giampaolo Talamo -- Current and future trials of targeted therapies and cutaneous melanoma / Matthew S. Evans...[et al.] -- Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma / Vikas Ghai...[et al.] -- Impact of genetic targets on primary brain tumor therapy: what's ready for prime time / O. Zalatimo...[et al.] -- Rational therapy for renal cell carcinoma based on its genetic targets / Jaime Messer, Joseph Drabick, Matthew Kang -- Molecular and genetic markers of follicular-cell thyroid cancer : etiology and diagnostic and therapeutic opportunities / Neerav Goyal...[et al.] -- Genetic targets in pediatric acute lymphoblastic leukemia / Chandrika Gowda, Sinisa Dovat -- Emerging molecular therapies for the treatment of acute lymphoblastic leukemia / Monali Vasekar...[et al.] -- Impact of genetic targets on prostate cancer therapy / Hassan Sheikh...[et al.] -- Small-cell lung cancer : an update on targeted therapues / Monika Joshi, Ayodele Ayoola, Chandra P. Belani -- Impact of genetic targets on cancer therapy in acute myelogenous leukemia / Mithun Vinod Shah, Amit Barochia, Thomas P. Loughran.
  • This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. ?These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.
  • Also available: Print – 2015
    In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development. The range of topics covered include the biology and management of fatigue and cognitive dysfunction on breast cancer survivorship, the biology and management of Neuropathy and Arthralgias, the ongoing research on the biology of diet and lifestyle interventions in survivors, and more. With the tremendous growth in the number of breast cancer survivors, researchers have moved beyond describing the outcomes of breast cancer treatments and are focusing their research on understanding the mechanisms underlying the development of the late effects of breast cancer treatment, as well as the development and evaluation of interventions to mitigate some of the persistent symptoms--topics which are also explored in this volume. In addition, current research on how to improve survivorship and reduce recurrence of breast cancer through behavioral and lifestyle modifications is also discussed.
  • Over the last 4 years, IMRT, IGRT, SBRT: Advances in the Treatment Planning and Delivery of Radiotherapy has become a standard reference in the field. During this time, however, significant progress in high-precision technologies for the planning and delivery of radiotherapy in cancer treatment has called for a second edition to include these new developments. Thoroughly updated and extended, this new edition offers a comprehensive guide and overview of these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity-modulated radiothera.
  • Also available: Print – 2006
    In remembrance of Rudolf Virchow (1821-1902) / Schmidt, A. -- In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia / Schmidt, A., Weber, O.F. -- Aneuploidy and cancer: from correlation to causation / Duesberg, P. ... [et al.] -- Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells / Trosko, J.E., Tai, M.-H. -- Helicobacter pylori and gastric neoplasia / Leung, W.K. -- Schistosomiasis and neoplasia / Yosry, A. -- Relevant oncogenic viruses in veterinary medicine: original pathogens and animal models for human disease / Truyen, U., L"chelt, M. -- The inflammatory tumor microenvironment and its impact on cancer development / de Visser, K.E., Coussens, L.M. -- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? / Pawelek, J. ... [et al.] -- Carcinogenesis driven by bone marrow-derived stem cells / Dittmar, T. ... [et al.] -- Chemokine-directed metastasis / Gomperts, B.N., Strieter, R.M. -- Involvement of chemokine receptors in organ-specific metastasis / Zlotnik, A. -- Visualization of tumor cell extravasation / Heyder, C. ... [et al.] -- Options for visualizing metastatic disease in the living body / Helms, M.W., Brandt, B.H., Contag, C. -- Infection, inflammation and neoplasia: an interdisciplinary challenge / Zaenker, K.S.
  • The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
  • Also available: Print – 2014
    While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neoplastic disease. In this patient population, infection risk results from a complex interplay between the host's underlying immunodeficiencies, local tumor effects, and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book, is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach, and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management, and prevention of infection and optimization of the overall care of patients with malignancies.
  • Also available: Print – 2014
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
  • v. 2, 2009 Springer Protocols
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • Basic concepts of inflammation and its role in carcinogenesis -- Inherited syndromes predisposing to inflammation and GI cancer -- Stem cells and inflammation in the intestine -- Acid reflux and oesophageal cancer -- Helicobacter pylori and gastric cancer -- Inflammatory bowel disease and colon cancer -- Primary sclerosing cholangitis -- Chronic inflammation and hepatocellular carcinoma -- Gastrointestinal cancer: current screening strategies -- Targeted drug therapies and cancer -- Genetics of inflammation in the gastrointestinal tract and how it can cause cancer -- Endoscopic methods.
  • Section I. Inflammation, oxidative stress, nutritional phytochemicals, and cancer -- section II. Signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals -- section III. In vivo absorption and pharmacokinetics of nutritional phytochemicals -- section IV. Vitamins A, D, and E cancer prevention and clinical perspective -- section V. Omega-3 and omega-6 fatty acids -- section VI. Flavonoids and polyphenols -- section VII. Garlic organosulfur compounds and crucifer glucusinolates -- section VIII. Selenium, herbal medicines, alpha lipoic acid, and cancer prevention -- section IX. Epigenetics and chronic inflammation.
  • Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs in women of all ages, and, rarely, in men. Variable disease presentation means that this disease is often undetected and patients with this diagnosis have a poor prognosis.Inflammatory Breast Cancer brings together the existing clinical information on inflammatory breast cancer. The content covers epidemiology, risk factors, diagnosis, histopathology and staging, therapy and management of patients with this disease. Recent advances in therapy have improved the prognosis of this type of cancer considerably, making this text a timely addition to the literature.This book is an essential tool for medical, surgical and clinical oncologists specialising in breast cancer, who will inevitably encounter this rare but pernicious disease.
  • Introduction: Why IBC Now? / Naoto T. Ueno and Massimo Cristofanilli -- Epidemiology of Inflammatory Breast Cancer / Shannon Wiggins, Sarah Taylor and Melissa Bondy -- Clinical Aspect of Inflammatory Breast Cancer: Diagnosis, Criteria, Controversy / Shaheenah Dawood and Vicente Valero -- Inflammatory Breast Cancer Registry / Jie S. Willey and Naoto T. Ueno -- Pathology: Histomorphometrical Features of IBC - Angiogenesis, Lymphangiogenesis, and Tumor Emboli / Sanford H. Barsky and Fredika M. Robertson -- Imaging for the Diagnosis and Staging of IBC / Wei Tse Yang -- Surgical Therapy for Inflammatory Breast Cancer / Sarah M. Gainer, Hideko Yamauchi and Anthony Lucci -- Radiation Therapy for Inflammatory Breast Cancer / Thomas A. Buchholz, Ian Bristol and Wendy Woodward -- Systemic and Targeted Therapy / Hideko Yamauchi, Teruo Yamauchi, Naoto T. Ueno and Vicente Valero -- Inflammatory Breast Cancer: Chemotherapy of Metastatic Disease / Anthony Gonçalves and Patrice Viens -- The Role of the Multidisciplinary Team in Inflammatory Breast Cancer / Nabila Chowdhury and Sandra M. Swain -- High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Inflammatory Breast Cancer / Yee Chung Cheng and Naoto T. Ueno -- Models of Inflammatory Breast Cancer / Lara Lacerda and Wendy A. Woodward -- Signaling Pathways in Inflammatory Breast Cancer / Dongwei Zhang and Naoto T. Ueno -- Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer / Madhura Joglekar and Kenneth L. van Golen -- Inflammatory Mediators as Therapeutic Targets for Inflammatory Breast Cancer / Fredika M. Robertson, Khoi Chu, Rita Circo, Julia Wulfkuhle and Lance Liotta, et al. -- Immunology of Inflammatory Breast Cancer / James M. Reuben and Bang-Ning Lee -- Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study / Peter B. Vermeulen, Gert Van den Eynden, Pascal Finetti, Daniel Birnbaum and Naoto T. Ueno, et al. -- Microarray Analysis Identifies an Expression Signature for Inflammatory Breast Cancer / François Bertucci, Pascal Finetti, Max Chaffanet, Patrice Viens and Daniel Birnbaum -- Cell Gene Expression Signatures in Inflammatory Breast Cancer / Wendy A. Woodward -- The Effect of Systemic Chemotherapy on Minimal Residual Disease in the Blood and Bone Marrow of Patients with Inflammatory Breast Cancer / Luc Y. Dirix, Dieter Peeters, Steven Van Laere and Peter B. Vermeulen -- Perspective of Patient Advocacy / Michelle Esteban and Patti Bradfield.
  • "A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
  • Preface -- Introduction -- The Digital Patient Model and Model Guided Therapy -- Hepatocellular Carcinoma and Patient Assessment -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- Imaging in Hepatocellular Carcinoma: PET/CT -- Personalized Chemotherapy for Hepatocellular Carcinoma -- Surgical Treatment for Hepatocellular Carcinoma.- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- Chapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- Minimally Invasive Therapies for Hepatocellular Cancer:Catheter-Directed Therapies -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- Design of an IT System for Hepatocellular Carcinoma -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.
  • Also available: Print – 2010
    Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • Obtaining and using genetic information -- Cancer and genetic counseling -- An ethos of genetic testing -- Hereditary breast cancer syndromes -- Gastrointestinal polyposis syndromes -- Familial colorectal cancer type X -- The familial atypical multiple mole melanoma (FAMMM)-pancreatic carcinoma (PC) syndrome -- Desmoid disease -- Hereditary nonpolyposis colorectal cancer -- Hereditary ovarian cancer and other gynecologic malignancies.
  • 1. VEGF inhibition increases hematocrit by hepatic Hif-2[Alpha]-dependent erythrocytosis and Hif-2[Alpha]--independent plasma volume contraction. Vascular Endothelial Growth Factor (VEGF) is an essential regulator of angiogenesis whose pharmacological inhibition represents a promising cancer therapeutic modality. We have previously reported that high-grade inhibition of VEGF by adenoviral expression of soluble VEGF receptor (VEGFR) ectodomains and recombinant VEGF Trap protein induce hepatic Epo-dependent erythrocytosis and polycythemia. Here, we demonstrate that VEGF inhibition induces erythrocytosis in a hepatic Hif-2[Alpha]-dependent manner. Conditional inactivation of hepatic Hif-2[Alpha] in Hif2[Alpha] flox/flox mice by either adenovirus Cre injection or albumin-Cre genetic cross suppressed VEGF inhibition-induced hepatic Epo production and blunted hematocrit elevation. Interestingly, a modest rise in hematocrit (5-10%) persisted in VEGF inhibitor-treated Hif-2[Alpha] liver knockout mice despite the absence of hepatic Epo elevation or reticulocytosis. Analysis of red blood cell mass and plasma volume indicate that, in addition to erythrocytosis, VEGF inhibition significantly reduces blood plasma volume (PV) (10-30% decrease) in a EPO- and Hif-2[Alpha]-independent manner. Thus, VEGF inhibition-induced hematocrit elevation in mice is attributable to both hepatic Hif-2[Alpha]-dependent erythrocytosis and Hif-2[Alpha] --independent plasma volume contraction, with accompanying implications for human patients exhibiting elevated haemoglobin levels in response to pharmacologic VEGF inhibition. 2. VEGF Inhibitors Enhance Hepatic insulin Signaling and Ameliorates Diabetes through Activation of Hepatic HIF-2[Alpha]. In the United States, over 18 million people have diabetes and approximately 90% of these cases are the type 2 form of the disease. The central pathophysiologic defect of T2DM is insulin resistance, where tissues such as muscle, fat and liver exhibit reduced responsiveness to insulin, despite normal to elevated levels of production of the hormone. During our studies on the role of vascular endothelial growth factor (VEGF) in erythropoeisis, we made a surprising observation that VEGF inhibition reduces blood glucose in normal lean mice and significantly corrects hyperglycemia in diabetic and insulin-resistant db/db mice. Metabolic profiling of VEGF inhibitor-treated mice revealed enhanced insulin sensitivity at the liver but not at the periphery. In the liver of these mice, expression of insulin receptor substrate-2 (IRS-2) was elevated, accompanied by enhanced Akt activation and suppression of gluconeogenic genes. Hepatic insulin sensitization by VEGF inhibitors requires hypoxia-inducible factor 2-alpha (Hif-2[Alpha]) as genetic deletion of hepatic Hif-2[Alpha] abrogated insulin sensitization and normalizes blood glucose in VEGF inhbitor-treated mice. Conversely, overexpression of a constitutively active allele of Hif-2[Alpha] in liver hepatocytes reduces blood glucose and activates hepatic insulin signaling in vitro and in vivo. Analysis of the human Irs-2 sequence revealed the presence of several potential Hypoxia-Responsive-Elements (HREs) within its 5' promoter. Using a Irs-2 promoter reporter construct, we found that overexpression of Hif-2[Alpha] or addition of a hypoxia-mimetic drug deferoxamine (DFO) resulted in increased Irs-2 transcription. These data suggest Irs-2 is a hypoxia-inducible gene. In this study, we show that VEGF inhibitors improve hepatic insulin action through activation of hepatic HIF-2[Alpha]. Our results suggest Hif-2[Alpha] positively regulates insulin signaling by promoting Irs-2 expression. These data suggest a previously unsuspected link between hypoxia and insulin signaling in the liver and indicate VEGF inhibitors may be useful for the treatment of diabetes.
  • "There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity. Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty. With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers."--Publisher's website.
  • Also available: Print – 2008
  • Also available: Print – 2006
  • 1. Insertional Mutagenesis: A Powerful Tool in Cancer Research -- 2. Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma -- 3. Gene Discovery by MMTV Mediated Insertional Mutagenesis -- 4. Chicken Models of Retroviral Insertional Mutagenesis -- 5. Sleeping Beauty Models of Cancer -- 6. Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials -- 7. Bioinformatics of High-Throughput Insertional Mutagenesis -- Index.
  • Insulin and the Physiology of Carbohydrate Metabolism -- Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis -- The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence -- Obesity and Cancer: Epidemiology -- Insulin, Insulin Resistance, and Cancer Associations -- Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer -- Potential Mechanisms Linking Insulin to Cancer -- Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation -- AMP-Activated Protein Kinase and Cancer Cell Metabolism -- The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analysis -- IGF-I and Insulin Receptor Families in Cancer -- Insulin Resistance: Clinical Implications for Cancer Treatment and Prevention.
  • Epidemiology of IGF-1 and cancer / Katharina Nimptsch and Eward Giovannucci -- Aging and cancer : the IGF- I connection / Kalina Biernacka, Claire Perks, and Jeff Holly -- Obesity, type 2 diabetes and cancer / Rosalyn D. Ferguson and Derek LeRoith -- IGF system and breast cancer / Marc A. Becker and Douglas Yee -- The role of insulin-like growth factor signaling in prostate cancer development and progression / Bruce Montgomery, James Dean, and Stephen Plymate -- IGF-1 cellular action and its relationship to cancer : evidence from in vitro and in vivo studies / Rosalyn D. Ferguson ... [et al.] -- Insulin-like growth factor signaling in pediatric sarcomas / Xiaolin Wan, Su Young Kim, and Lee J. Helman -- Cancer genes, tumor suppressors, and regulation of IGF1-R gene expression in cancer / Haim Werner ... [et al.] -- Mouse models of IGF-1R and cancer / Craig I. Campbell, James J. Petrik, and Roger A. Moorehead -- Targeting the insulin-like growth factor-I receptor in cancer therapy / David R. Clemmons -- Targeting insulin-like growth factor receptor 1 (IGF-1R) and insulin receptor signaling by tyrosine kinase inhibitors in cancer / Joan M. Carboni, Mark Wittman, and Fei Huang -- Calories and cancer : the role of insulin-like growth factor-1 / Stephen D. Hursting ... [et al.] -- Cancer cell metabolism / Akash Patnaik, Jason W. Locasale, and Lewis C. Cantley -- Overlaps between the insulin and IGF-I receptor and cancer / Antonino Belfiore and Roberta Malaguarnera.
  • Microenvironmental effects on tumour progression and metastasis -- Role of microenvironment on gene expression, angiogenesis and microvascular function in tumors -- Imaging of angiogenesis in vivo with fluorescent proteins -- The epigenetic influence of the tumor microenvironment on melanoma plasticity -- Dynamics of cell adhesion interactions during melanoma development -- Matrix metalloproteinases: mediators of tumour-host cell interactions -- Role of brain microenvironments in brain metastases -- Influence of the bone microenvironment on breast cancer metastasis to bone -- Interaction of tumour with host stroma in hepatocellular carcinoma -- Dynamic nature of tumour-host interactions within the tumor microenvironment -- Breast cancer progression: a "vicious cycle" of pro-malignancy activities is mediated by inflammatory cells, chemokines and cytokines -- Tumor and host endothelial cell selective interactions and modulation by microenvironmental chemokines: tumor-endothelial cell cross talk specificity -- The role of chemokine receptors, in particular CXCR4, in lymphoma and carcinoma metastasis -- Energy homeostasis and the tumor/host interaction: the role of the brain -- Anti-angiogenic and pro-apoptotic effects of dietary restriction in experimental brain cancer: role of glucose and ketone bodies -- Dietary restriction of specific amino acids modulates tumor and host interactions -- Role of tumour microenvironment in chemoresistance -- Integrin-mediated resistance to chemotherapy-induced apoptosis in cancer cells -- Bone metastasis microenvironment participates in the development of androgen ablation refractoriness and chemotherapy resistance of prostate cancer cells residing in the skeleton: clinical implications -- Current and future therapeutic targets of the tumour-host microenvironment -- Bone stromal cells as therapeutic targets in osseous metastasis -- Organtropism of lung cancer metastasis and its molecular targeted therapy -- Maspin: a novel serine protease inhibitor -- Metastasis suppressor genes: a brief review of an expanding field -- Tumor-host interactions at the metastatic site: MKK4, signal transduction and the stress response.
  • Introduction -- A word of caution: risk of harm associated with alternative complementary/integrative approaches in cancer management and the critical need for quality research to understand and decrease that risk -- Using legal and ethical principles to guide clinical decision making in complementary/integrative cancer medicine -- Communicating with patients about the use of complementary and integrative medicine in cancer care -- The integrative medicine program at The University of Texas M. D. Anderson Cancer Center -- The integrative medicine service at Memorial Sloan-Kettering Cancer Center -- Integrative oncology-Leonard P. Zakim Center: the Dana-Farber Cancer Institute experience -- The Johns Hopkins complementary and integrative medicine service -- Integrative oncology at Mayo Clinic: research informing practice -- Mind-body research in cancer -- Herbs and other botanicals: interactions with pharmaceuticals -- Acupuncture in cancer care at Dana-Farber Cancer Institute: an integrative medical practice -- Acupuncture for the side effects of cancer treatments.
  • This practice-oriented handbook covers complementary and alternative medicine (CAM) practices in pediatric oncology worldwide, with a focus on methods used in Western countries. Provides a road map for establishing integrative pediatric oncology worldwide.
  • Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.
  • The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
  • Prostate brachytherapy has been the subject of heated debate among surgeons and the proponents of the various brachytherapy methods. This very first interdisciplinary book on the subject provides a comprehensive overview of innovations in low dose rate (LDR), high dose rate (HDR), and pulsed dose rate (PDR) interstitial brachytherapy for the management of local or locally advanced prostate cancer. In addition to detailed chapters on patient selection and the use of imaging in diagnostics, treatment guidance, and implantation control, background chapters are included on related medical physics issues such as treatment planning and quality assurance. The results obtained with the different treatment options and the difficult task of salvage treatment are fully discussed. All chapters have been written by internationally recognized experts in their fields who for more than a decade have formed the teaching staff responsible for the successful GEC-ESTRO/EAU Prostate Brachytherapy Teaching Course. This book will be invaluable in informing residents and others of the scientific background and potential of modern prostate brachytherapy. It will also prove a useful source of up-to-date information for those who specialize in prostate brachytherapy or intend to start an interstitial brachytherapy service.
  • Interventional Oncology is a fast-growing new field, as well as an emerging specialty. Many minimally-invasive, imaging-guided procedures seem set to replace more traditional open surgical techniques of treating solid tumors in a variety of organs. The aim of this book is to describe new interventional radiological methods in a succinct and practical form. Diagnostic radiological considerations relevant to the selection and follow-up of patients are also covered. The book begins with an overview of the basic principles of current interventional techniques, including thermal ablation, high intensity focused ultrasound, and embolization. Later chapters focus on tumors of the liver, kidney, lung, and bone, placing new interventional techniques in context by referring to the surgical and oncologic methods of treating the same conditions. With an emphasis on best practices, Interventional Oncology: A Practical Guide for the Interventional Radiologist will serve as a definitive guide to practicing physicians involved in this rapidly evolving field.
  • The Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice.The series comprises a number of titles, which cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, ablation, pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice.Interventional Radiology Techniques in Ablation is a practical and concise guide to contemporary techniques in image-guided tumor ablation. This handbook is intended to serve as a quick reference for physicians in interventional radiology training as well as a resource for IR technologists, nurses, nurse practitioners and physician assistants.
  • Interventions in Pulmonary Medicine is an important new volume that addresses all areas of interventional pulmonology, a minimally invasive endoscopic way to diagnose and treat lung disorders. This volume contains dedicated chapters that outline the many issues related to lung cancer, both in early and advanced stages, from diagnosis to personalized treatment. It also covers bronchoscopic therapeutic options to benign conditions that are highly prevalent, such as COPD and asthma. Techniques described in this volume are: laser therapy, argon plasma coagulation therapy, cryotherapy, brachytherapy, placement of intrapleural drainage systems, endoscopic treatment of emphysema, stents in the airway, and thermoplasty for bronchial asthma. Diagnostic procedures that are covered are: medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, electromagnetical navigation, and trends in personalized treatment for lung cancer and other benign lung conditions. Chapters are written by experts and the developers of the techniques that are currently considered gold standard. Evidence-based reviews are presented for all topics and indications, and contraindications are discussed. Interventions in Pulmonary Medicine is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.
  • Intraductal papillary mucinous neoplasms (IPMNs) represent an opportunity to treat pancreatic tumors before they develop into aggressive, hard-to-treat cancers. Beginning with morphological classification and its clinical significance, natural history, and malignant change of both main duct and branch duct IPMNs, this book covers the whole field of IPMNs of the pancreas. It reviews the various methods of investigation: imaging, diagnostic investigation of cyst fluid, and those using pancreatic juice; and also examines aspects ranging from the development of malignancy to the timing and method of resection, focusing on both main duct and branch duct IPMNs. Aimed at residents, clinical fellows, and pancreatologists who treat patients with this common disease of the pancreas, this book is a landmark in the current understanding and future perspectives of IPMNs of the pancreas.
  • General rationale and historical perspective -- Rationale and historical perspective of intraoperative irradiation -- Biology of large dose per fraction irradiation -- Methods and techniques of treatment -- Intraoperative electron beam irradiation: physics and techniques -- HDR-IORT: physics and techniques -- Electronic brachytherapy/low KV-IORT: physics and techniques -- IORT with electron-beam, high-dose-rate brachytherapy or low-KV/electronic brachytherapy: methodological comparisons -- Normal tissue tolerance: IORT -- Normal-tissue tolerance to IOERT, EBRT, or both: animal and clinical studies -- Results of IORT alone or plus EBRT by disease site -- Central nervous system tumors -- Head and neck cancer -- Breast cancer -- Lung cancer -- Gastric cancer -- Pancreas cancer -- Bile duct and gallbladder cancer -- Primary colorectal cancer -- Recurrent colorectal cancer -- Retroperitoneal sarcomas -- Extremity and trunk soft-tissue sarcomas -- Bone sarcomas -- Gynecologic malignancies -- Genitourinary cancer -- Pediatric malignancies -- Conclusions and future possibilities -- Conclusions and future possibilities: IORT.
  • "Intraoperative MR-Guided Neurosurgery contains detailed coverage of this state-of-the-art technology from the pioneers who developed it. World-renowned neurosurgeons and neuroradiologists combine their collective wisdom and experience to demonstrate how MR-guided neuronavigation can be used to view real-time images of a patient's brain during surgery to help remove tumors with greater precision. The authors provide step-by-step descriptions of how to perform procedures, including advice based on their clinical results. Readers will learn about the advantages and drawbacks of the various MR imaging systems, clinical indications for MR-guidance, anesthesia considerations, safety concerns related to working in a magnetic environment, and much more"--Provided by publisher.
  • This volume acquaints the non-neuropathologist with the advantages of clinical-radiologic-pathologic correlation in neuropathology specimens, particularly in the intra-operative environment. This volume covers the enormous and sometimes insurmountable artifacts involed with freezing tissue, especially central nervous system tissue and how a good cytology preparation can add to, or even supply in isolation, a diagnosis. The text presents how to perform, and stain the cytologic preparations, and how to interpret them. The advantages and disadvantages of both frozen sections and cytologic preparations of various kinds are discussed. The presentation and format is very visual with diagrams, tables (including pearls and pitfalls), and many figures (therefore easy reading).An introductory chapter presents the pros and cons of supplemental cytology, the advantages and disadvantages of frozen sections, and the artifacts in both. Also included is an argument for knowing what the scans reveal and the impact of relevant patient history. The volume uses a case-based approach to show correlation between scan, history, frozen section and cytologic preparations.With the combination of extensive correlation of scans, cytology and frozen section with differential diagnosis, and analysis of the information crucial to the neurosurgeon in a case-based approach and with a special chapter written by a neuroradiologist, this volume is unique in presentation and utility and will be of great value to the trainee in pathology (residents/fellows), and practicing pathologists who include neuropathology in their practice, but do not have formal fellowship training in neuropathology.
  • Management of ovarian cancer : the theory / Maurie Markman -- Management of ovarian cancer : clinical trials / Maurie Markman -- A systematic review and meta-analysis of randomized trials / Kenneth Jaaback -- Immunobiology and intraperitoneal immunobiologics in ovarian cancer / Ralph S. Freedman -- Intraperitoneal chemotherapy : technique and complications / Joan L. Walker -- Hyperthermia and chemotherapy : the science / Roger A. Vertrees, Jeffrey M. Jordan, and Joseph B. Zwischenberger -- Hyperthermic intraperitoneal chemotherapy in nongynecologic cancers / Bing Yi, Jason M. Foster, and Brian W. Loggie -- Peritoneal carcinomatosis of colorectal origin / Frans A.N. Zoetmulder -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : experience in France / Olivier Glehen and Francois-Noel Gilly -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : world experience / C. William Helm -- Techniques of delivering hyperthermic intraperitoneal chemotherapy / Jesus Esquivel, Paul H. Sugarbaker, and C. William Helm -- Future directions in the delivery of hyperthermic intraperitoneal chemotherapy / Scott Richard and Robert P. Edwards.
  • Current chemotherapy of ovarian cancer -- Principles of intraperitoneal chemotherapy -- Intraperitoneal chemotherapy: phase III trials -- Criteria for using intraperitoneal (IP) chemotherapy for advanced ovarian cancer -- Selection and placement of intraperitoneal catheters for IP chemotherapy for ovarian cancer -- Selection of drugs for intraperitoneal chemotherapy for ovarian cancer -- Administration guidelines for intraperitoneal chemotherapy for ovarian cancer -- Novel drugs for intraperitoneal therapy for ovarian cancer -- Cytoreductive surgery and perioperative intraperitoneal chemotherapy: an ongoing research effort -- Health-related quality of life and patient-reported outcomes.
  • Chapter 1. Ultrasound, general considerations -- Chapter 2. The interventional cytopathologist -- Chapter 3. The thyroid gland -- Chapter 4. The parathyroid gland -- Chapter 5. The salivary glands -- Chapter 6. The head and neck, miscellaneous lesions -- Chapter 7. The lymph nodes -- Chapter 8. The breast -- Index.
  • Also available: Print – 2007
    The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
  • Basic principles of head and neck surgery -- Scalp and skin -- Eyelids and orbit -- Nasal cavity and paranasal sinuses -- Skull base -- Lips -- Oral cavity -- Pharynx and esophagus -- Larynx and trachea -- Cervical lymph nodes -- Thyroid and parathyroid glands -- Salivary glands -- Neurogenic tumors and paragangliomas -- Soft tissue tumors -- Bone tumors, including odontogenic lesions -- Reconstructive surgery -- Oncologic dentistry, maxillofacial prosthetics, and implants -- Radiation therapy -- Chemotherapy.
  • Part 1: Epidemiology and Biology Epidemiology of Kidney Cancer -- Pathological Classification -- Molecular Biology of Kidney Cancer -- Biomarkers for Kidney Cancer -- Genetic Heterogeneity of Kidney Cancer -- Metabolic Basis of Kidney Cancer. Part 2: Clinical Considerations Clinical Presentation and Staging.- Hereditary Kidney Cancer. Part 3: Surgical and Local Control Modalities Surgical Approaches to Early Stage Kidney Cancer -- Cytoreductive Nephrectomy -- Metastasectomy -- Energy Ablative Techniques in Kidney Cancer -- The Role of Radiation Therapy in Kidney Cancer. Part 4: Systemic Therapy Considerations Adjuvant Systemic Therapy -- Cytokines and Vaccine Therapy -- PD1 and PDL1 Targeted Therapy -- Angiogenesis Inhibitor Therapy -- The Role of mTOR inhibitors and PI3K Pathway Blockade -- Sequential versus Combination Strategies -- Presurgical Therapy in Kidney Cancer -- Toxicity Management for Patients on Targeted Therapies -- Emerging Agents in Kidney Cancer.
  • "Kidney Cancer: Principles and Practice is an interdisciplinary textbook that encompasses all clinically relevant aspects of the disease and is designed to be as user-friendly as possible in order to meet the needs of the busy practitioner. To this end, the informative text is complemented by helpful boxed sections that present essential 'take home' points and patient-oriented cases demonstrating the clinical application of elements discussed in the chapter in question. Original high-quality images, some in color, are included whenever necessary to simplify particularly complex material. The authors are an international group of acknowledged experts in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others. This clinically oriented volume will be of great interest to clinicians, researchers, residents, and fellows, as well as to students and knowledgeable lay people."--Publisher's website.
  • Killer lymphocytes 2005
    Also available: Print – 2005
  • Centromeres and kinetochores : an historical perspective / Kerry S. Bloom -- The basics of chromosome segregation / Mitsuhiro Yanagida -- The centromere / Beth A. Sullivan -- Neocentromeres / Owen J. Marshall and K.H. Andy Choo -- Human artificial centromeres : de novo assembly of functional centromeres on human artificial chromosomes / Hiroshi Masumoto, Teruaki Okada, and Yasuhide Okamoto -- Kinetochore composition, formation, and organization / Tatsuo Fukagawa and Peter De Wulf -- Evolution of centromeres and kinetochores : a two-part fugue / Paul B. Talbert, Joshua J. Bayes, and Steven Henikoff -- Mitotic spindle assembly mechanisms / Rebecca Heald and Claire E. Walczak -- Kinetochore-microtubule interactions / Lesley Clayton and Tomoyuki U. Tanaka -- Post-translational modifications that regulate kinetochore activity / Chitra V. Kotwaliwale and Sue Biggins -- The role of the kinetochore in spindle checkpoint signaling / P. Todd Stukenberg and Daniel J. Burke -- Kinetochore regulation of anaphase and cytokinesis / Scott Thomas and Kenneth B. Kaplan -- Roles of centromeres and kinetochores in meiosis / Adele L. Marston -- The kinetochore-cancer connection / Takeshi Tomonaga -- The kinetochore as target for cancer drug development / Song-tao Liu and Tim J. Yen.
  • Indication, Collection, and Laboratory Processing of Cytologic Samples -- The Cellular and Acellular Components of the Urinary Sediment -- The Cytologic Makeup of the Urinary Sediment According to the Collection Technique -- Cytologic Manifestations of Benign Disorders Affecting Cells of the Lower Urinary Tract -- Tumors and Related Conditions of the Bladder and Lower Urinary Tract -- Urine-Based Assays Complementing Cytologic Examination in the Detection of Urothelial Neoplasm.
  • "Written by an internationally recognized multidisciplinary team of authors, Kuerer's Breast Surgical Oncology is the first text specifically dedicated to breast surgical oncology. ... Kuerer's examines all clinically relevant knowledge in the field, from the pathology of the breast and clinical management, to follow-up and complications following diagnosis and therapy. The book also focuses on the next wave of molecular studies that represent the future of the discipline."--BOOK JACKET.
  • Also available: Print – 2009
    Part I. Overview of brain tumor survivorship -- Introduction to brain tumor survivorship and historical perspective / Stewart Goldman and Christopher D. Turner -- Late effects of neurosurgery / Arthur J. DiPatri, Martin Pham, and Kenji Muro -- Late effects of CNS radiation therapy / Helen A. Shih, Jay S. Loeffler, and Nancy J. Tarbell -- Late effects of chemotherapy / Sridharan Gururangan -- Late effects of stem cell transplantation in brain tumor survivors / Karina Danner-Koptik, David A. Jacobsohn, and Kimberley J. Dilley -- Effect of cancer treatment on neural stem and progenitor cells / Jörg Dietrich and Santosh Kesari -- The pediatric brain tumor late effects clinic / Kimberly J. Dilley and Barbara Lockart -- Part II. Medical late effects of brain tumor treatment -- Neurological complications in adults / Michelle Monje and Patrick Y. Wen -- Neurological complications in children / Sonia Partap and Paul Graham Fisher -- Strokes among childhood brain tumor survivors / Daniel C. Bowers -- Endocrine late effects: manifestations and treatments / Jason R. Fangusaro and Elizabeth Eaumann Littlejohn -- Ocular consequences and late effects of brain tumor treatments / María E. Echevarría and Joanna L. Weinstein -- Auditory late effects of chemotherapy / Anna K. Meyer and Nancy M. Young -- Reproductive health issues in survivors of childhood and adult brain tumors / Tress Goodwin, B. Elizabeth Delasobera, and Paul Graham Fisher -- Cancer predisposition syndromes / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral -- Secondary neoplasms following treatment for brain tumors / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral.
  • Also available: Print – 2010
    Section I. Radiation biology and physics -- Section II. Imaging -- Section III. Radiation oncology -- Part 1. Central nervous system -- Part 2. Head and neck tumors -- Part 3. Tumors of the thorax -- Part 4. Gastrointestinal tumors -- Part 5. Urologic tumors -- Part 6. Gynecologic tumors -- Part 7. Pediatric tumors -- Part 8. Cancer of the breast -- Part 9. Adult sarcomas -- Part 10. Lymphomas -- Part 11. Ocular cancer -- Part 12. Skin cancer -- Part 13. Benign disease -- Section IV. Emerging radiation modalities.
  • Also available: Print – 2005
    Anatomy and physiology of the leptomeninges and CSF space / Neil Barshes, Alexis Demopoulos and Herbert H. Engelhard -- Leptomeningeal neoplasia: epidemiology, clinical presentation, CSF analysis and diagnostic imaging / Roelien H. Enting -- Leptomeningeal metastases from solid tumors (Meningeal carcinomatosis) / Michiko Kimura Bruno and Jeffrey Raizer -- Leptomeningeal metastases from leukemias and lymphomas / Craig P. Nolan and Lauren E. Abrey -- Leptomeningeal metastasis of primary central nervous system (CNS) neoplasms / Herbert H. Engelhard and Luke A. Corsten -- Leptomeningeal cancer in the pediatric patient / Kathleen A. Neville and Susan M. Blaney -- Neurosurgical interventions for leptomeningeal tumor / Jeffrey P. Greenfield and Mark H. Bilsky -- Current treatment of leptomeningeal metastases: systemic chemotherapy, intrathecal chemotherapy and symptom management / Stacey L. Berg and Marc C. Chamberlain -- Radiation therapy for leptomeningeal cancer / Minesh Mehta and Kristin Bradley -- Animal models of leptomeningeal cancer / Ali Raja and Herbert H. Engelhard -- Improving the outcome of patients with leptomeningeal cancer: new clinical trials and experimental therapies / Kurt Jaeckle.
  • Leukaemia 2003
    Wellcome Trust
  • Leukemia : methods and protocols 2009
    Springer Protocols
    An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia / C.W. So -- Backtracking of leukemic clones to birth / J. Wiemels, M. Kang and M. Greaves -- Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia / Z.J. Konn ... [et al.] -- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research / L. Kearney and S. Colman -- LDI-PCR: identification of known and unknown gene fusions of the human MLL gene / C. Meyer and R. Marschalek -- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences / B.W. Robinson and C.A. Felix -- MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR / V.H. van der Velden and J.J. van Dongen -- Array-based comparative genomic hybridization as a tool for analyzing the leukemia genome / J.C. Strefford and H. Parker -- Application of SNP genotype arrays to determine somatic changes in cancer / M. Gupta and B.D. Young -- Retroviral/Lentiviral transduction and transformation assay / B.B. Zeisig and C.W. So -- Gene expression profiling of leukemia stem cells / A.V. Krivtsov ... [et al.] -- Humanized model to study leukemic stem cells / D. Bonnet -- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction / M. Wunderlich and J.C. Mulloy -- Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells / J.J. Schuringa and H. Schepers -- Identification and characterization of hematopoietic stem and progenitor cell populations in mouse bone marrow by flow cytometry / J. Yeung and A.C. Wai Eric So -- In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development / P. Sroczynska ... [et al.] -- Analysis of the mouse placenta as a hematopoietic stem cell niche / K. Ottersbach and E. Dzierzak -- Identification of protein interaction partners by the yeast two-hybrid system / M.P. Garcia-Cuellar, D. Mederer and R.K. Slany -- Complete array of HOX gene expression by RQ-PCR / G.J. Dickson, T.R. Lappin and A. Thompson -- Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias / M.E. Figueroa, A. Melnick and J.M. Greally -- Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins / T.A. Milne, K. Zhao and J.L. Hess.
  • Artificial light and human temporal organization. Artificial light and its physiochemical properties -- Light and dark cycles as a basis of temporal organization -- Biological clock and its entrainment by photoperiod -- Light at night (LAN) exposure and its potential effects on daily rhythms and seasonal disruptions -- Melatonin : "hormone of darkness" and a "Jack of all traits" -- Light pollution, its known health effects and impact on energy conservation. Introduction and spread of artificial illumination : a human history retrospective -- Biological definition of light pollution -- Light-at-night (LAN) as a general stressor -- Effects of light pollution on animal daily rhythms and seaonality : ecological consequences -- Light polluiton and hormone-dependent cancers : a summary of accumulated empirical evidence -- Light pollution and its potential links to breast and prostate cancers. Geographic patterns of breast and prostate cancers (BC&PC) worldwide -- Light pollution and its associations with BC&PC in population-level studies -- Selected methodological issues of LAN-BC&PC reserach -- Dark-less world : what is next? (conclusions and prospects for future research).
  • Also available: Print – 2006
    Inflammation and cancer: the role of the immune response and angiogenesis / Angus G. Dalgleish and Ken O'Byrne -- Chronic inflammation and pathogenesis of GI and pancreatic cancers / Lindsey N. Jackson and B. Mark Evers -- Cytokines, NF-[kappa]B, microenvironment, intestinal inflammation and cancer / Arndt J. Schottelius and Harald Dinter -- Regulation of NF-[kappa]B transcriptional activity / Linda Vermeulen, Wim Vanden Berghe and Guy Haegeman -- The role of immune cells in the tumor microenvironment / Theresa L. Whiteside -- Tumor-microenvironment interactions: the seletcin-selectin ligand axis in tumor-endothelium cross talk / Isaac P. Witz -- CD95L/FasL and trail in tumour surveillance and cancer therapy / Harald Wajant -- Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer / Jessica Berout and Andrei Thomas-Tikhonenko -- Cytokines as mediators and targets for cancer cachexia / Josep M. Argilés, Sílvia Busquets and Francisco J. López-Soriano -- Targeting NF-[kappa]B in anticancer adjunctive chemotherapy / Burkhard Haefner.
  • The lip is the most common site of malignancy in the head and neck region. Although high cure rates can be achieved by early treatment, a significant percentage of lip cancers demonstrate aggressive behaviour, posing management difficulties. Given the aesthetic and functional significance of the lip, reconstruction post surgery is also extremely important, yet this, too, can be challenging. This textbook is intended as a comprehensive reference that will provide easy-to-follow and well-organized guidance on the management of lip cancer, from diagnosis to treatment and reconstruction. After discussion of anatomy and premalignant conditions, detailed attention is paid to squamous cell carcinoma of the lip. Surgical management is explained, and the roles of radiation therapy and chemotherapy, discussed. Reconstruction techniques following ablative surgery are then described in depth, with reference to defect size and complexity. In addition, the potential complications of treatment and reconstruction are presented, with advice on their management. The closing chapter considers other malignant lesions of the lip. The informative text is complemented by high-quality illustrations and clinical and radiographic material. The contributors all have extensive experience and in-depth knowledge of the topics they address.
  • Also available: Print – 2009
    Structure and synthesis of lipid A / Shoichi Kusumoto, Masahito Hashimoto and Kazuyoshi Kawahara -- Conformation and supramolecular structure of lipid A / Klaus Brandenburg and Ulrich Seydel -- Interactions between lipid A and serum proteins / Jèorg Andrèa ... [et al.] -- The lipid A receptor / Kiyoshi Takeda -- Lipid A receptor TLR4-mediated signaling pathways / Masahiro Yamamoto and Shizuo Akira -- Lipid A-induced responses in vivo / Néjia Sassi ... [et al.] -- Lipid A-mediated tolerance and cancer therapy / Cheryl E. Rockwell, David C. Morrison and Nilofer Qureshi -- Lipid A in cancer therapies : preclinical results / Daniele Reisser and Jean-François Jeannin -- Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines : clinical results / Christopher W. Cluff -- Antitumoral effects of lipids A : clinical studies / Marc Bardou and Danièle Reisser.
  • Also available: Print – 2001
  • Liver cancer 2009
  • Liver metastases 2009
  • Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
  • OBJECTIVES: We prepared this report on the comparative effectiveness and harms of lung-directed nonsurgical therapies for non-small-cell lung cancer (NSCLC) in three distinct patient populations: (1) patients with stage I NSCLC who are not surgical candidates (Key Question 1), (2) patients with stage I NSCLC who are deemed operable but decline surgery (Key Question 2), and (3) patients with endoluminal NSCLC causing obstruction (Key Question 3). For stage I NSCLC, the local nonsurgical interventions could include conformal radiotherapy modalities and radiofrequency ablation (RFA). For patients with airway obstruction due to an endoluminal NSCLC, local nonsurgical interventions could include those for the stage I setting, as well as conventional wide-field radiotherapy, brachytherapy, laser and mechanical debridement, endoluminal stents, cryoablation, and photodynamic therapy. Surgical resection of any type is not considered as a comparator for any of the Key Questions. DATA SOURCES: MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry were searched from January 1, 1995, to July 25, 2012. A search of the gray literature included databases with regulatory information, clinical trial registries, abstracts and conference papers, and information from manufacturers. REVIEW METHODS: We sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverse events, and quality of life among our populations of interest. Data were abstracted for each Key Question by a team of reviewers, with independent data verification. Study quality and the risk of bias of randomized controlled trials (RCTs) were assessed using the United States Preventive Services Task Force criteria. The quality and risk of bias of single-arm studies were assessed using the Carey and Boden criteria. The strength of the body of evidence was assessed according to the Agency for Healthcare Research and Quality Methods Guide. RESULTS: In our searches, we identified 4,648 unique titles and screened 1,178 in full text. Of the latter, 55 met the inclusion criteria. Thirty-five studies were relevant to Key Question 1, considering medically inoperable patients with stage I NSCLC; 6 were relevant to Key Question 2, considering medically operable patients with stage I NSCLC who decline surgery; and 17 were relevant to Key Question 3, considering patients with inoperable endoluminal NSCLC causing symptoms of obstruction. Three studies addressed both Key Questions 1 and 2. All studies relevant to Key Questions 1 and 2 were single-arm design, prospective (n=15), retrospective (n=21), or not specified (n=2). Among 17 papers included for Key Question 3, 5 were RCTs, 1 was a nonrandomized comparative study, and 11 were single-arm studies. Because comparative study evidence on RFA and debridement and stenting was unavailable for Key Question 3, we included evidence from two single-arm studies involving stents and one on RFA. All RCTs were of poor quality. Only one comparison was available per study, with no two studies examining the same set of interventions. Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of life. CONCLUSIONS: Evidence on localized nonsurgical therapies for patients with stage I NSCLC who are not surgical candidates or who decline surgery consists only of single-arm studies, with no direct comparisons among interventions. The best evidence for NSCLC patients with endoluminal obstruction consists of poor-quality single RCTs for each comparison; we did not identify evidence that permitted us to draw conclusions based on indirect comparisons. Overall, evidence is insufficient to permit conclusions on the comparative effectiveness of local nonsurgical therapies for inoperable or operable patients with stage I NSCLC or inoperable NSCLC patients with endoluminal tumor causing pulmonary symptoms.
  • Basics of Regional Tumor therapies: Locoregional Tumor Therapies, Evidence and Future -- Pharmacokinetic of Locoregional Tumor Therapies -- Embolization Materials, Catheter, IA-port systems Indications for locoregional tumor therapies ? Liver: HCC -- Liver Metastases of CRC- Liver Metastases of Neuroendocrine Tumors and CCC -- Liver metastases of other indications: Pancreas Carcinoma -- Melanoma -- Breast Carcinoma. Indications for locoregional tumortherapies ? Lung: Basics -- Primary Lung Tumors -- Lung metastases Thermoablation: Liver -- Lung. Head and Neck.
  • Lung cancer 2003
    Springer Protocols
    v. 2 Springer Protocols
    v. 1. Molecular pathology methods and reviews -- v. 2. Diagnostic and therapeutic methods and reviews.
  • Also available: Print – 2005
    Etiology and epidemiology -- Lung cancer biology -- Screening/early detection/prevention -- Pathology and molecular classification -- Clinical presentation, diagnosis, staging, and prognosis -- Surgery -- Radiation therapy -- Chemotherapy -- Multimodality therapy of NSCLC -- Treatment of small cell lung cancer -- Novel therapeutic strategies -- Palliation and special considerations -- Other thoracic tumors.
  • Also available: Print – 2015
    Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.
  • Lung cancer imaging 2013
    While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their.
  • Lung Cancer: Overview / Shirish M. Gadgeel and Gregory P. Kalemkerian -- Hallmarks of Metastasis / M. Roshni Ray and David M. Jablons -- Tumor Stem Cells and Metastasis / Jaclyn Y. Hung -- Epithelial-Mesenchymal Transition as a Mechanism of Metastasis / Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni and Aristidis Moustakas -- Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis / Charles Kumar Thodeti and Kaustabh Ghosh -- Immunologic Mechanisms in Lung Carcinogenesis and Metastasis / Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma and Tonya Walser, et al. -- Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis / Douglas A. Arenberg -- Chemokines in Lung Cancer Metastasis / Borna Mehrad, Ellen C. Keeley and Robert M. Strieter -- Molecular Control of Lymphatic Metastasis in Lung Cancer / Mark M. Fuster and Judith A. Varner -- Carcinoma-Associated Fibroblasts in Lung Cancer / Roya Navab, Bizhan Bandarchi and Ming-Sound Tsao -- The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer / Zvi G. Fridlender, M. Cecilia Crisanti and Steven M. Albelda -- Experimental Animal Models for Studying Lung Cancer / Jiang Liu and Michael R. Johnston -- Molecular Imaging in Lung Cancer Metastases / Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross and Alnawaz Rehemtulla -- Biomarker Discovery for Metastatic Disease / Gilbert S. Omenn and James D. Cavalcoli -- Current Clinical Management of Metastatic Lung Cancer / Bryan J. Schneider and Suresh S. Ramalingam -- Site-Directed Therapy for Lung Cancer Metastases / Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens and Malini Venkatram, et al. -- Systems Approach for Understanding Metastasis / Peter J. Woolf, Angel Alvarez and Venkateshwar G. Keshamouni.
  • "Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology, namely, needle biopsy and bronchoscopy, fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation, Nodule segmentation, Vessels segmentation, Airways segmentation, Lung registration, Detection of lung nodules, Diagnosis of detected lung nodules, Shape and appearance analysis of lung nodules. Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging"--Provided by publisher.
  • Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.
  • Lymphoma : methods and protocols 2005
    Springer Protocols
    Also available: Print – 2005
  • Pt. 1. Introduction -- pt. 2. Central nervous system lymphomas -- pt. 3. Primary CNS lymphoma -- pt. 4. Variants of CNS lymphoma -- pt. 5. Neurological complications of lymphomas and leukemias -- pt. 6. Neurological complications of therapy for lymphomas and leukemias.
  • Lymphoma-- methods and protocols 2013
    Springer Protocols
    Origin and pathogenesis of B cell lymphomas / Marc Seifert, René Scholtysik, and Ralf Küppers -- Flow cytometry for non-Hodgkin and classical Hodgkin lymphoma / David Wu, Brent L. Wood, and Jonathan R. Fromm -- Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells / Ralf Küppers, Markus Schneider, and Martin-Leo Hansmann -- PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by genescan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics / Elke Boone, Brenda Verhaaf, and Anton W. Langerak -- Expression cloning of human B cell immunoglobulins / Hedda Wardemann and Juliane Kofer -- Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR / Menno C. van Zelm, Magdalena A. Berkowska, and Jacques J.M. van Dongen -- Detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies / Martin J.S. Dyer -- Stereotyped B cell receptors in B cell leukemias and lymphomas / Nikos Darzentas and Kostas Stamatopoulos -- Flow cytometric MRD detection in selected mature B-cell malignancies / Sebastian Böttcher, Matthias Ritgen, and Michael Kneba -- MRD Detection in B-cell non-hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR / Christiane Pott [and others] -- Enrichment of methylated DNA by methyl-CpG immunoprecipitation / Miriam Sonnet [and others] -- Gene expression profile analysis of lymphomas / Katia Basso and Ulf Klein -- FISH and FICTION to detect chromosomal aberrations in lymphomas / Maciej Giefing and Reiner Siebert -- Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens / Vu N. Ngo -- Studying microRNAs in lymphoma / Joost Kluiver, Izabella Slezak-Prochazka, and Anke van den Berg -- Molecular methods of virus detection in lymphoma / Ruth F. Jarrett, Alice Gallagher, and Derek Gatherer -- High-throughput RNA sequencing in B-cell lymphomas / Wenming Xiao [and others].
  • Part 1. Classification, Opportunities and Challenges -- Classification of Anticancer Drugs Based on Therapeutic Targets -- Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy -- Part 2. Polymer-Based Anticancer Prodrugs -- HPMA-Anticancer Drug Conjugates -- Poly-l-Glutamic Acid Anti-cancer Drug Conjugates -- Polysaccharide-Based Anticancer Prodrugs -- PEG-Anticancer Drugs -- Poly(ethylene glycol)-Protein, Peptide, and Enzyme Conjugates -- Part 3. Lipid-Based -- Anticancer Prodrugs -- Lipid-Based Anticancer Prodrugs -- Part 4. Antibody-Directed Cancer Therapy -- Antibody-Cytotoxic Compound Conjugates for Oncology -- Immunoconjugate Anticancer Therapeutics -- Antibody-Directed Enzyme Prodrug Therapy (ADEPT) for Cancer -- EGFR-Directed Monoclonal Antibodies -- The Biology of the HER Family and Her2/neu Directed-Antibody Therapy -- Anti-Vascular Endothelial Growth Factor Monoclonal Antibodies -- Monoclonal Antibody Therapy for Hematologic Malignancies -- Part 5. Anticancer Oligonucleotide Therapeutics -- Anticancer Oligonucleotides -- Part 6. Miscellaneous -- New Molecular Therapeutic Interventions: The Case of Breast Cancers.
  • The first question -- Physics facts that will improve your images -- Screening mammography 101 and beyond -- The recalled patient : now what? findings on mammography -- Breast anatomy and physiology : knowing what's normal -- Calcifications made easy -- Management of masses : BI-RADS 2, 3, or 4? -- Multiple circumscribed masses -- Architectural distortion -- Mammographic asymmetries -- Expanding the differential diagnosis : going beyond IDC-NOS screening detection -- Finding cancers in dense tissue -- Measuring and managing breast cancer risk diagnostic exams/management -- The painful and the palpable -- Evaluation of nipple discharge -- The male breast -- Imaging the patient with breast cancer postoperative studies -- The postoperative breast -- Evaluating women with implants interventions -- Breast needle biopsy : tips for challenging cases.
  • Morphological and Functional Characteristics of Serous Cavities / Olga V. Lebedinskaya, Irina Zh Shubina, Natalia Yu Anisimova, Alexey N. Kopylov and Mikhail V. Kiselevsky -- Pathogenesis of Malignant Effusions / Irina O. Chikileva, Natalia Yu Anisimova, Irina Zh Shubina and Mikhail V. Kiselevsky -- Diagnosis and Treatment of Malignant Pleural Effusion / Sergi Call, David Sánchez and Ramón Rami-Porta -- Malignant Ascites: Diagnosis and Treatment / Fausto Petrelli and Sandro Barni -- Malignant Pericardial Disease / Caroline Chiles and Girish Shroff -- Adoptive Immunotherapy of Malignant Effusions / Irina Zh Shubina, Konstantin S. Titov, Irina O. Chikileva, Lev V. Demidov and Mikhail V. Kiselevsky -- Hyperthermia and Intracavitary Chemotherapy in Prevention and Treatment of Malignant Effusions / Gianfranco Baronzio, Giammaria Fiorentini, Marco Ballerini, Valter Cassuti and Giorgio Forzenigo, et al.
  • Mineralogy of Asbestos -- Epidemiology of Mesothelioma and Historical Background -- Imaging of Mesothelioma -- Biopsy Techniques for the Diagnosis of Mesothelioma -- Pathohistological Diagnosis and Differential Diagnosis -- Mesothelioma and Analysis of Tissue Fiber Content -- Surgical Therapy of Mesothelioma -- Chemotherapy and Radiotherapy for Mesothelioma -- Genetics and Molecular Biology of Mesothelioma -- Early Stages of Mesothelioma, Screening and Biomarkers.
  • Also available: Print – 2005
  • Signs and symptoms -- Diagnostic Studies of Pediatric Bone Tumors: Pathology and Imaging -- Basic Principles of Biopsy -- The evaluation of lung nodules in pediatric bone tumors -- Fertility Preservation and Reproductive Health in Pediatric Bone Tumor Patients -- Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors -- Radiation Management -- Histologic Response and Biologic Markers -- Surgical Approach: Limb Salvage Versus Amputation -- Rehabilitation following Orthopaedic Surgery in Children with Bone Tumors -- Patient Navigation of the Pediatric Bone Tumor Patient Across the Continuum of Care -- Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care -- Post-therapy surveillance of bone tumors -- Recurrent Bone Tumors -- Novel Therapies on the Horizon -- Survivorship.
  • Gastroesophageal cancers : providing an update / Jaffer A. Ajani -- Epidemiology and etiology of gastric cancer / Amitesh Roy, David Cunningham & Ian Chau -- Surgery of esophagogastric cancer : standards and challenges / Markus Moehler, Anne Palmqvist, Hauke Lang, Hans-Joachim Meyer & Ines Gockel -- Chemotherapy / Vincenzo Catalano & Francesco Graziano -- Targeted therapies / David H. Ilson & Elizabeth C. Smyth -- Guidelines for managing gastric cancer / Vikas Ghai & Yixing Jiang.
  • This book provides a single, comprehensive reference source that incorporates the epidemiology, natural history, and the latest genetic and molecular biological findings of bladder cancer. This book discusses the diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer and incorporates the new findings on markers for the diagnosis of bladder cancer. Risk stratified treatment of non-muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline-based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. This book covers the application of chemotherapy for muscle invasive and advanced disease. The evidence-based application of multimodality therapy is highlighted. Gaps in current knowledge and important areas for clinical research are highlighted. Authored by experts in their respective fields, Management of Bladder Cancer: A Comprehensive Text with Clinical Scenarios serves as an easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.
  • 1. Background and Epidemiology -- Basic Science of Breast Cancer in Older Patients / Irmgard Irminger-Finger -- Tumor Biology and Pathology / Virginie Durbecq and Denis Larsimont Clinical Epidemiology and the Impact of Co-Morbidity on Survival / Adri C. Voogd, Marieke J. Louwman and Jan Willem W. Coebergh -- 2. Special Considerations in the Management of Older Women -- Comprehensive Geriatric Assessment / Margot A. Gosney -- A Practical Mini-Guide to Comprehensive Geriatric Assessment / Siri Rostoft Kristjansson -- Impact of the Physiological Effects of Aging on the Pharmacokinetics and Pharmacodynamics of Systemic Breast Cancer Treatment / Paul Hamberg, Maja J. A. de Jonge and Caroline M. Seynaeve -- Impact of Hormone Replacement Therapy on Breast Cancer / Toral Gathani and Valerie Beral -- Experiences of a Multidisciplinary Elderly Breast Cancer Clinic: Using the Right Specialists, in the Same Place, with Time / Anne Stotter, Mohammad Tahir, Robert S. Pretorius and Thompson Robinson -- 3. Therapeutics -- Mammographic Breast Screening in Elderly Women / Lynda Wyld -- Primary Endocrine Therapy for the Treatment of Early Breast Cancer in Older Women / Lynda Wyld and Daniel Hind -- Peroperative Radiotherapy / Roberto Orecchia, Giovanni Battista Ivaldi and Maria Cristina Leonardi -- General and Local Anesthetics / Bernadette Th. Veering -- The Surgical Management of Breast Cancer in Elderly Women / Malcolm W. R. Reed, Lynda Wyld and Riccardo A. Audisio -- Breast Reconstruction / Marcus J. D. Wagstaff, Malcolm W. R. Reed and Christopher M. Caddy -- Adjuvant Endocrine Therapy / Laura Biganzoli -- Adjuvant Chemotherapy / Sumanta Kumar Pal, Nilesh Vora and Arti Hurria -- Adjuvant Radiotherapy / Pierre G. M. Scalliet -- Prevention and Treatment of Skeletal Complications / Matthew C. Winter, Helen L. Neville-Webbe and Robert E. Coleman -- Medical Management of Advanced Disease / Hans P. M. W. Wildiers -- The Use of Chemotherapy in Elderly Cancer Patients: Dose Adjusting, Drug Interactions, and Polypharmacy / Lazzaro Repetto and Claudia Di Bartolomeo -- 4. Psychosocial Considerations -- Delayed Presentation of Breast Cancer in Older Women / Lindsay J. L. Forbes and Amanda J. Ramirez -- Patient Decision Making / Martine Extermann -- Culture, Ethnicity, and Race: Persistent Disparities in Older Women with Breast Cancer / Antonella Surbone and Marjorie Kagawa-Singer -- Supportive, Palliative and End-of-Life Care for Older Breast Cancer Patients / Elaine Cachia, Ruth Broadhurst and Sam H. Ahmedzai.
  • Anatomy and Physiology of the Breast -- Congenital and Developmental Abnormalities of the Breast -- Nipple Discharge -- Mastalgia -- Management of Common Lactation and Breastfeeding Problems -- Evaluation of a Breast Mass -- Breast Cancer Epidemiology -- Breast Cancer Screening -- Breast Imaging -- Premalignant and Malignant Breast Pathology -- Lobular Carcinoma in Situ -- Ductal Carcinoma in Situ -- Surgical Considerations in the Management of Primary Invasive Breast Cancer -- Sentinel Node Concept -- Breast Reconstructive Surgery -- The Role of Radiotherapy in Breast Cancer Management -- Adjuvant Systemic Therapy for Breast Cancer: An Overview -- Endocrine Therapy -- Chemotherapeutic Agents -- HER2-Targeted Therapy -- Inflammatory and Locally Advanced Breast Cancer -- Preoperative (Neoadjuvant) Systemic Therapy -- Metastatic Breast Cancer -- Hormone Replacement Therapy: A Critical Review -- Breast Diseases in Males -- Breast Cancer in the Elderly -- Breast Cancer in Younger Women -- Psychological Support for the Breast Cancer Patient -- Management of the Patient with a Genetic Predisposition for Breast Cancer -- Chemoprevention of Breast Cancer -- Design, Implementation, and Interpretation of Clinical Trials -- Structure of Breast Care Center -- Medicolegal Pitfalls in Breast Cancer Diagnosis and Management.