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  • PET in oncology 2008
  • PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Ba\0302enard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
  • Provides practical, useful information for utilizing this novel imaging techniquefrom different methods for contouring biological target volumes in various anatomic regions to how different experts use this imaging in targeted treatment. This thorough text helps you make concise, accurate treatment choices based on current evidence and expert authority. The result is an helpful tool for everyone on the radiotherapy treatment team in the era of image-guided radiotherapy. Covers the use of PET-CT with radiotherapy treatment planning, offering practical guidance in how different experts use this relatively new technology. Outlines the advantages and disadvantages of different techniques in contouring PET-CT target volumes for radiotherapy. Features case illustrations in using PET-CT in radiotherapy.
  • Principles of Cancer Treatment / William G. Newman and Fiona H. Blackhall -- Clinical Pharmacology and Anticancer Drugs / Cristina Rodríguez-Antona and Julia Kirchheiner -- Principles of Genetics and Pharmacogenetics / William G. Newman -- Pharmacogenetics in the Management of Breast Cancer / Sacha J. Howell -- Pharmacogenetics in Colorectal Cancer / Roberta Ferraldeschi -- Pharmacogenetics in Lung Cancer / Fiona Blackhall -- Pharmacogenetics and Cancer Treatment in Children / P. Kellie Turner and Gareth J. Veal -- Pharmacogenetics in Palliative Care / Andrew A. Somogyi -- Genetic Predictors of Normal Tissue Response to Radiotherapy / Catharine M.L. West, Gillian C. Barnett, Alison M. Dunning, Rebecca M. Elliott and Neil G. Burnet -- Cancer Pharmacogenetics in Industry / Mireille Cantarini -- Ethical Issues in Pharmacogenetics / Tara Clancy -- Economics of Cancer Pharmacogenetics / Katherine Payne -- Future Advances in Cancer Pharmacogenomics / William G. Newman.
  • What next in colorectal cancer? / James Cassidy -- Pathophysiology and drug targets in metastatic colorectal cancer / Autumn McRee & Howard L. McLeod -- First-line chemotherapy / Yoko Yanagisawa, Rachel Midgley & David Kerr -- Monoclonal antibodies / Giuseppe Tonini, Marco Imperatori, Alice Zoccoli, Michele Iuliani & Francesco Pantano -- Drugs in clinical trials / Irene Braña, Rodrigo Dienstmann, Jaume Capdevila & Josep Tabernero -- Which therapy for which patient? / Patryk Kambakamba, Stefan Breitenstein, Panagiotis Samaras, Paul Magnus Schneider & Georg Lurje.
  • This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors (e.g., medical, social cognitive, environmental) are discussed, and behavior change strategies for increasing physical activity in cancer survivors (e.g., counseling, print materials) are appraised. The final part of the book is devoted to further special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
  • Epidemiology of overweight/obesity and cancer risk -- Epidemiology of physical activity and cancer risk -- Energetics and cancer: exploring a road less traveled -- Calorie restriction, exercise, and colon cancer prevention: a mechanistic perspective -- Mechanisms linking obesity to cancer risk -- Mechanisms underlying the effects of physical activity on cancer -- Physical activity, weight control, and cancer prognosis.
  • Measuring endogenous electric fields / Richard Nuccitelli -- Investigation systems to study the biological effects of weak physiological electric fields / Francis X. Hart -- Endogenous bioelectric signals as morphogenetic controls of development, regeneration, and neoplasm / Michael Levin -- Stem cell physiological responses to noninvasive electrical stimulation / Igor Titushkin ... [et al.] -- Electrical signals control corneal epithelial cell physiology and wound repair / Colin D. McCaig -- Physiological electric fields can direct keratinocyte migration and promote healing in chronic wounds / Christine E. Pullar -- Electrical control of angiogenesis / Entong Wang ... [et al.] -- Inflammatory cell electrotaxis / Francis Lin and Christine E. Pullar -- Effects of DC electric fields on migration of cells of the musculoskeletal system / Najmuddin J. Gunja, Clark T. Hung, and J. Chlöe Bulinski -- Neuronal growth cone guidance by physiological DC electric fields / Ann M. Rajnicek -- Can applied voltages be used to produce spinal cord regeneration and recovery in humans? / Richard Ben Borgens -- Bioelectricty of cancer : voltage-gated ion channels and direct-current electric fields / Mustafa B. A. Djamgoz.
  • Statistical analysis of pineal tumors based on the data of brain tumor registry of Japan / Shibui, S., Nomura, K. -- Pathology of pineal parenchymal tumors / Sato, K., Kubota, T. -- Occipital transtentorial approach and combined treatments for pineal parenchymal tumors / Tsumanuma, I., Tanaka, R., Fujii, Y. -- Role of stereotactic radiosurgery in the management of pineal parenchymal tumors -- Kano, H. ... [et al.] -- Pathology of intracranial germ cell tumors / Sato, K., Takeuchi, H., Kubota, T. -- Pineal germ cell tumors / Matsutani, M. -- Strategy of combined treatment of germ cell tumors / Sawamura, Y. -- Radiation therapy for intracranial germ cell tumors / Aoyama, H. -- Stereotactic radiosurgery for pineal and related tumors / Mori, Y. ... [et al.] -- Management of central nervous system germinoma : proposal for a modern strategy / Shibamoto, Y. -- Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy / Sugiyama, K. ... [et al.].
  • Polyploidy, aneuploidy, and the evolution of cancer / Lauren M.F. Merlo ... [et al.] -- Molecular mechanisms and function of the spindle checkpoint : a guardian of the chromosome stability / Daisuke Ito and Tomohiro Matsumoto -- Understanding cytokinesis failure / Guillaume Normand and Randall W. King -- DNA damage and polyploidization / Jeremy P.H. Chow and Randy Y.C. Poon -- Role of the p53 family in stabilizing the genome and preventing polyploidization / Flaminia Talos and Ute M. Moll -- Centrosomes, polyploidy, and cancer / Anette Duensing and Stefan Duensing -- Polyploidy : mechanisms and cancer promotion in hematopoietic and other cells / Hao G. Nguyen and Katya Ravid -- Polyploidization of liver cells / Séverine Celton-Morizur and Chantal Desdouets -- Analysis of cellular DNA content by flow and laser scanning cytometry / Zbigniew Darzynkiewicz, H. Dorota Halicka, and Hong Zhao.
  • Positron emission tomography 2011
    Springer Protocols
    FDG-PET/CT in lymphoma / Malik E. Juweid -- FDG PET imaging of head and neck cancers / Yusuf Menda and Michael M. Graham -- Pet and PET-CT of lung cancer / Hans C. Steinert -- PET-CT in radiotherapy for lung cancer / Dirk De Ruysscher -- PET and PET-CT in esophageal and gastric cancer / Hinrich A. Wieder, Bernd J. Krause and Ken Herrmann -- FDG PET and PET/CT for colorectal cancer / Dominique Delbeke and William H. Martin -- Functional imaging of neuroendocrine tumors / Sofie Van Binnebeck, Wolfram Karges, and Felix M. Mottaghy -- Melanoma / Esther Bastiaannet, Harald J. Hoekstra, and Otto S. Hoekstra -- Breast cancer / Johannes Czernin, Matthias R. Benz, and Martin S. Allen-Auerbach -- Gynecological cancers / Norbert Avril, Sofia Gourtsoyianni, and Rodney Reznek -- Sarcoma / Sarah Ceyssens and Sigrid Stroobants -- PET and PET/CT in the management of thyroid cancer / Sandip Basu [and others] -- PET in testicular cancer / Alexander Becherer -- Pancreatic and hepatobiliary cancers / Andreas K. Buck [and others] -- Prostate cancer / Hossein Jadvar -- Brain tumors / Serge Goldman and Benoit J.M. Pirotte -- PET and PET/CT for unknown primary tumors / Thomas C. Kwee, Sandip Basu, and Abass Alavi -- Methodological aspects of multicenter studies with quantitative PET / Ronald Boellaard.
  • This handbook, written in a clear and precise style, describes the principles of positron emission tomography (PET) and provides detailed information on its application in clinical practice. The first part of the book explains the physical and biochemical basis for PET and covers such topics as instrumentation, image reconstruction, and the production and diagnostic properties of radiopharmaceuticals. The focus then turns to the use of PET in clinical practice, including its role in hybrid imaging (PET-CT). A wide range of oncological applications are discussed, including for cancers of the head and neck, breast, lung, digestive system, urinary tract, female reproductive system, and prostate, lymphoproliferative disorders, melanoma, and musculoskeletal tumors. Uses of PET in cardiology, neurology, and psychiatry are also addressed. Characteristic findings are described and illustrated by numerous images, many of them in color. This book will be of value not only for nuclear medicine physicians and radiologists but also for all oncologists, surgeons, cardiologists, neurologists, psychiatrists, and residents with an interest in molecular imaging.
  • A Practical Guide to Human Cancer Genetics, 4th edition, is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This fully updated new edition covers risk analysis and genetic counseling for individuals with a family history of cancer, and includes a discussion of predictive testing and the organisation of the cancer genetics service. There is also information about the genes causing Mendelian cancer predisposing conditions and their mechanisms of action. This book is an invaluable reference source for students, general practitioners, geneticists and specialist clinicians in all disciplines.
  • An overview of the management of thyroid cancer -- The UK evidence-based guidelines for the management of thyroid cancer: key recommendations -- Thyroid cancer multidisciplinary team and the organisational paradigm -- Thyroid cancer form the perspective of a patient -- The role of the specialist nurse -- The role of the clinical psychologist -- Thyroid nodules -- Thyroid cancer and the general practitioner -- The role of pathologist -- Thyroid cancer and the endocrinologist -- The specialist endocrine surgeon -- Initial thyroid surery for patient with differentiated thyroid carcinoma -- Management of cervical lymph nodes in differentiated thyroid cancer -- Complications of thyroid surgery -- Non-surgical management of thyroid cancer -- Fertility following treatment with iodine-131 for thyroid cancer -- Recombinant human TSH (rhTSH): use in papillary and follicular thyroid cancer -- Thyroglobulin -- Follow-up of patients with differentiated thyroid carcinoma --- Management of differentiated thyroid carcinoma patients with negative whole-body radioiodine scans and elevated serum thyroglobulin levels -- Medullary thyroid cancer: diagnosis and management -- Nonmedullary thyroid cancer and the role of the geneticist -- Thyroid cancer in childhood -- Radiation-induced thyroid cancer: lessons from Chernobyl -- The use of stable potassium iodide (KI) in the event of a nuclear emergency -- Ultrasound of the thyroid -- Diagnostic nuclear medicine investigations in the management of thyroid cancer -- CT and MRI in thyroid cancer -- Papillary microcarcinoma of the thyroid -- Rare thyroid cancers -- Management of anaplastic thyroid cancer -- Specialist palliative care for anaplastic thyroid carcinoma -- Emerging therapies for thyroid cancer -- Clinical trials for thyroid carcinoma: past, present, and future.
  • "While the first edition of this book was written during my 9 years working at the University of Gt̲tingen in the field of MR mammography, this second edition reflects not only the innovative changes in the performance and analysis of MR mammography but also my new vantage point modified by the shift of my working field. The current edition includes all the experience I have accumulated during the last 7 years of work at the Women's Health Care Center, Gt̲tingen. In this frame of reference, where individualized and optimal diagnostic strategies are implemented for the early detection of breast cancer, MR mammography has increasingly earned a central role. It has also shown itself to be the most reliable diagnostic method for staging and follow-up after breast cancer"--Provided by publisher.
  • Reference dosimetry for ionizing radiation -- Relative dosimetry for MV beams -- In-vivo dosimetry -- Quality assurance and commissioning of new radiotherapy technology -- Quality assurance of radiotherapy dose calculations -- Immobilization techniques in radiotherapy -- Image guidance and localization technologies for radiotherapy -- Brachytherapy -- Proton radiotherapy -- Radiation safety and shielding in radiotherapy -- Information technology in radiation oncology -- Quality and safety improvement in radiation oncology -- Simulation for radiotherapy treatment planning -- Treatment planning and quality metrics -- The use of electrons for external beam radiotherapy -- IMRT and VMAT -- SRS and SBRT -- Clinical aspects of image guidance and localization in radiotherapy -- Respiratory motion management for external beam radiotherapy -- Intracavitary brachytherapy -- Interstitial brachytherapy -- Prostate seed implant -- Intraoperative radiotherapy (IORT) -- Special procedures -- Resource documents.
  • Introduction : tumor classification and biologic potential / Jason L. Hornick -- Grading and reporting of soft tissue sarcomas / Jason L. Hornick -- Spindle cell tumors / Adrian Marino-Enriquez, Louis Guillou, and Jason L. Hornick -- Pediatric spindle cell tumors / Cheryl M. Coffin -- Tumors with myxoid stroma / Alessandra F. Nascimento and Jason L. Hornick -- Epithelioid and epithelial-like tumors / Essia Saiji, Louis Guillou, and Jason L. Hornick -- Pleomorphic sarcomas / J. Frans Graadt Van Roggen and Pancras C.W. Hogendoorn -- Round cell tumors / Enrique De Alava -- Biphasic tumors and tumors with mixed patterns / Alessandra F. Nascimento and Jason L. Hornick -- Tumors associated with prominent inflammatory cells / Jason L. Hornick -- Giant cell-rich tumors / Bernadette Liegl-Atzwanger and Jason L. Hornick -- Adipocytic tumors / Licia Laurino and Angelo Paolo Dei Tos -- Vascular tumors / Briana C. Gleason and Jason L. Hornick -- Cartilaginous and osseous soft tissue tumors / Andre M. Oliveira -- Cutaneous mesenchymal tumors / Thomas Brenn and Jason L. Hornick -- Mesenchymal tumors of the gastrointestinal tract / Brian P. Rubin and Jason L. Hornick -- Lower genital soft tissue tumors / Marisa R. Nucci -- Applications of molecular testing to differential diagnosis / Alexander J. Lazar.
  • This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase ? the period from surgical removal of tissue to the start of pathological processing ? have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
  • 5050 pt. 1. Pathogenesis -- pt. 2. Model systems and clinical approaches -- pt. 3. Disease specific examples -- pt. 4. Common threads.
  • Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma. -Molecular Pathology of Lobular Carcinoma Ali Sakhdari, Lloyd Hutchinson, Ediz Cosar -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.
  • Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject.
  • Treatment tolerance is a challenge for most cancer patients, and it is therefore essential that healthcare professionals (HCPs) are quick to recognize adverse events and implement management strategies to address them. Prevention of Nausea and Vomiting in Cancer Patients provides comprehensive guidance on managing nausea and vomiting, which are common and often severe adverse events experienced by patients receiving chemotherapy and radiotherapy. The book refers to the latest American Society of Clinical Oncology (ASCO), European Society of Medical Oncology (ESMO), and Multinational Association for Supportive Care in Cancer (MASCC) guidelines and will be a useful resource for oncologists, oncology fellows, general physicians, and other HCPs wishing to learn more about the effective management of chemotherapy-and radiotherapy-induced nausea and vomiting in cancer patients.
  • Overview of the topic -- Meaning of SPC -- Importance of SPC -- Framework and methodology -- Lymphomas -- Leukemias -- Breast cancer (female) -- Lung cancer -- Cancers of the head and neck -- Gastrointestinal cancers -- Genitourinary cancers -- Gynecologic cancers -- Skin cancers -- Pediatric cancers -- Summary of significant SPC associations -- Population health priorities.
  • Epidemiology and risk factors -- Molecular pathogenesis -- Cellular origins of malignant glioma: the cancer stem cell polemic -- Principles of supportive care -- Principles of clinical trial design and response assessment -- Complications of therapy -- Neuropsychological function and quality of life -- Low-grade gliomas -- High-grade astrocytomas -- Anaplastic oligodendrogliomas and mixed gliomas -- Ependymomas -- Uncommon gliomas in adults: brainstem gliomas, pilocytic astrocytomas, and pleomorphic xanthastrocytomas -- Pediatric tumors -- Primary central nervous system lymphoma -- Meningiomas -- Pituitary adenomas -- Vestibular schwannomas -- Medulloblastomas -- Pineal region tumors -- Genetic syndromes -- Rare tumors -- Spinal tumors.
  • Concepts, Challenges and Perspectives in Cancer Research / Jianren Gu, Wenxin Qin, Zhigang Zhang -- Systemic Dysregulation in the Development of Hepatocellular Carcinoma / Jianren Gu, Xianghuo He, Zhenfeng Zhang, Weijie Guo, Zhiao Chen -- Genomics of Hepatocellular Carcinoma / Chunming Wong, Irene Oi Lin Ng -- Biomarkers of Hepatocellular Carcinoma / Hongyang Wang, Wen Wen -- Metabonomics of Hepatocellular Carcinoma / Peiyuan Yin, Guowang Xu -- Signal Transduction of Hepatocellular Carcinoma / Hongyang Wang, Yaqin He, Wen Yang -- Cancer Stem Cells of Hepatocellular Carcinoma / Gangming Zou, Jinjun Li, Jianren Gu -- Immunology of Liver / Zhigang Tian, Yongyan Chen -- Immunosuppresssion and Immune Escape in Liver Cancer / Qingqing Wang, Xuetao Cao -- Immunotherapy of Hepatocellular Carcinoma / Zhinan Chen, Huijie Bian, Jinliang Xing, Jianli Jiang, Yu Li -- Chemoprevention of Hepatic Cancer in Aflatoxin Endemic Areas / Thomas W. Kensler, John D. Groopman, Patricia A. Egner -- Metastasis of Hepatic Cancer / Zhaoyou Tang -- Integrated Treatment of Hepatic Cancer / Mengchao Wu, Feng Shen, Jiamei Yang, Weiping Zhou, Yiqun Yan -- Liver Transplantation for Hepatocellular Carcinoma / Shusen Zheng.
  • Hepatocellular Carcinoma: Etiology and Natural History / Tinsay A. Woreta and James P. Hamilton -- Surveillance for Hepatocellular Carcinoma / Reezwana Chowdhury and Rohit Satoskar -- Radiologic Diagnosis of Hepatocellular Carcinoma / Stephen Thomas and Aytekin Oto -- Pathology of Hepatocellular Carcinoma / Shriram Jakate and Deborah Giusto -- Differential Diagnosis of Focal Hepatic Lesions / Russell N. Wesson and Andrew M. Cameron -- Paraneoplastic Syndromes / Po-Hung Chen and Ayman Koteish -- Hepatocellular Carcinoma in Children / Christiane Sokollik, Abha Gupta and Simon C. Ling -- Staging of Hepatocellular Carcinoma / Chalermrat Bunchorntavakul, Maarouf Hoteit and K. Rajender Reddy -- Liver Anatomy and Function in the Planning of Hepatic Interventions / Nicholas N. Nissen and Alagappan Annamalai -- Treatment of HCC: Resection, Local-Regional Therapy, Systemic Therapy, and Liver Transplantation / Nate Susnow, Talia B. Baker and Laura Kulik -- Recurrence: Prevention and Management / Natasha Chandok and Paul Marotta -- The Impact of Treating Chronic Liver Diseases on Hepatocellular Carcinoma Prevention / Narayan Dharel and Daryl T. Lau -- Emerging Serum Biomarkers of HCC / Anjana A. Pillai and Claus J. Fimmel -- Emerging Therapies for Hepatocellular Carcinoma / Renumathy Dhanasekaran and Roniel Cabrera.
  • pt. 1. Past, present and future of primo vascular system research -- pt. 2. Primo vascular system in various organs -- pt. 3. Primo microcell (sanAI) and stem cells -- pt. 4. Cancer -- pt. 5. Imaging, oxygen, physiology and others -- pt. 6. Acupuncture.
  • Infections in patients with cancer : overview / Amar Safdar, Gerald Bodey, and Donald Armstrong -- Infections in hematopoietic stem cell transplant recipients / Georg Maschmeyer and Per Ljungman -- Infections in patients with hematologic malignancies / Genovefa Papanicolaou and Jayesh Mehta -- Infections in solid tumor patients / Alison G. Freifeld -- Infections in patients with hematologic malignancies treated with monoclonal antineoplastic therapy / André Goy and Susan O'Brien -- Postsurgery infections in cancer patients / Emilio Bouza ... [et. al] -- Management of infections in critically ill cancer patients / Henry Masur -- Management of the neutropenic patient with fever / Kenneth V. I. Rolston and Gerald P. Bodey -- Controversies in empiric therapy of febrile neutropenia / John R. Wingard -- Catheter-related infections in cancer patients / Iba Al Wohoush, Anne-Marie Chaftari, and Issam Raad -- Intravascular device-related infections : catheter salvage strategies and prevention of device-related infection / Nasia Safdar and Dennis G. Maki -- Pneumonia in the cancer patient / Scott E. Evans and Amar Safdar -- Noninfectious lung infiltrates that may be confused with pneumonia in the cancer patient / Rana Kaplan ... [et. al] -- Mucosal barrier injury and infections / Nicole M. A. Blijlevens and J. Peter Donnelly -- Bacterial colonization and host immunity / Coralia N. Mihu, Karen J. Vigil, and Javier A. Adachi -- Neutropenic enterocolitis and clostridium difficile infections / Amar Safdar ... [et. al] -- Management of reactivation of hepatitis B and hepatitis C during antineoplastic therapy / Marta Davila and Harrys A. Torres -- Management of genitourinary tract infections / Amar Safdar and Maurie Markman -- Central nervous system infections in cancer patients / Victor Mulanovich and Amar Safdar -- Endocarditis in oncology patients / Sara E. Cosgrove and Aruna Subramanian -- Skin disorders difficult to distinguish from infections / Sharone Hymes, Susan Chon, and Ana Ciurea -- Overview of invasive fungal disease in oncology patients / Amar Safdar -- Diagnosis of invasive fungal disease / Dionissios Neofytos and Kieren Marr -- Invasive candidiasis in management of infections in cancer patients / Matteo Bassetti ... [et. al] -- Management of aspergillosis, zygomycosis, and other clinically relevant mold infections / Konstantinos Leventakos and Dimitrios P. Kontoyiannis -- Cryptococcal disease and endemic mycosis / Johan A. Maertens and Hélène Schoemans -- Current controversies in the treatment of fungal infections / Christopher D. Pfeiffer, John R. Perfect, and Barbra D. Alexander -- Fungal drug resistance and pharmacologic considerations of dosing newer antifungal therapies / Russell E. Lewis and David S. Perlin -- Immunotherapy for difficult-to-treat invasive fungal diseases / Brahm H. Segal, Amar Safdar, and David A. Stevens -- Cytomegalovirus in patients with cancer / Morgan Hakki, Per Ljungman, and Michael Boeckh -- Epstein-Barr virus, varicella zoster virus, and human herpes viruses-6 and -8 / Mini Kamboj and David M. Weinstock -- Respiratory viruses / Roy F. Chemaly, Dhanesh B. Rathod, and Robert Couch -- BK, JC and parvovirus infections in patients with hematologic malignancies / Véronique Erard and Michael Boeckh -- Antiviral resistance and implications for prophylaxis / Robin K. Avery -- Management of gram-positive bacterial disease : staphylococcus aureus, streptococcal, pneumococcal, and enterococcal infections / Samuel Shelburne and Daniel M. Musher -- Infections caused by aerobic and anaerobic gram-negative bacilli / Kenneth V. I. Rolston, David E.Greenberg, and Amar Safdar -- Listeriosis and nocardiosis / Heather E. Clauss and Bennett Lorber -- Antibacterial distribution and drug-drug interactions in cancer patients / Ursula Theuretzbacher and Markus Zeitlinger -- Mycobacterium tuberculosis infection / Michael Glickman -- Nontuberculous mycobacterial infections / Amar Safdar -- Parasitic infections in cancer patients : toxoplasmosis, strongyloidiasis and other parasites / Brian G. Blackburn and José G. Montoya -- Zoonoses in cancer patients / Donald Armstrong -- Antibiotic stewardship : considerations for a cancer Center / Coralia N. Mihu, Alla Paskovaty, and Susan K. Seo -- Controversies in antimicrobial stewardship / Graeme N. Forrest -- Prevention of antimicrobial resistance : current and future strategies / Cesar A. Arias and Adolf W. Karchmer -- Antibacterial, antifungal, and antiviral prophylaxis / Marcio Nucci and John R. Wingard -- Controversies in antimicrobial prophylaxis / Ben de Pauw and Marta Stanzani -- Infection prevention : protected environment and infection control / J. Peter Donnelly -- Prevention of tropical and parasitic infections : the immunocompromised traveler / Francesca F. Norman and Rogelio López-Vélez -- Prophylactic vaccination of cancer patients and hematopoietic stem cell transplant recipients / William Decker and Amar Safdar.
  • Gastrointestinal cancer: epidemioloy -- Gastrointestinal cancer: pathology and molecular pathology -- Gastrointestinal cancer: cancer genetics -- Gastrointestinal cancer: screening and surveillance -- Gastrointestinal cancer: surgical oncology -- Gastrointestional cancer management: biological aspects of radiation therapy -- Gastrointestinal cancer: medical oncology -- Gastrointestinal cancer: nutritional support -- Imaging of gastrointestinal malignancies -- Endoscopic diagnosis, staging, and management of gastrointestinal cancers -- An overview of outcomes research in gastrointestinal cancer -- Integrative oncology: complementary therapies in gastrointestinal cancer care -- Pain and symptom control -- Esophageal cancer: epidemiology, screening, and prevention -- The molecular genetics of esophageal cancer -- Esophageal cancer: pathology -- Esophageal cancer: anatomy and staging -- Esophageal cancer: clinical management -- Gastric cancer: epidemiology, screening, surveillance, and prevention -- Gastric cancer: molecular biology and genetics -- Gastric cancer: pathology -- Gastric cancer: staging systems and techniques -- Gastric cancer: clinical management -- Pancreas cancer: epidemiology and risk factors -- Pancreatic cancer: molecular biology and genetics -- Pancreas cancer: anatomy, staging systems, and techniques -- Pathology of pancreatic cancer -- Pancreas cancer: clinical management -- Hepatocellular carcinoma: epidemiology, screening and prevention -- Hepatocellular carcinoma: molecular biology and genetics -- Hepatocellular cancer: pathology -- Hepatocellular cancer: anatomy and staging -- Hepatocellular cancer: clinical management -- Cancer of the gallbladder and biliary tree: epidemiology -- Pathology of biliary tract cancer -- Cancers of the biliary tree: anatomy and staging -- Cancers of the biliary tree: clinical management -- Environmental and lifestyle issues in colorectal cancer -- Colorectal cancer: screening and surveillance -- Colorectal cancer: molecular biology and genetics -- Colorectal cancer: pathology -- Colorectal cancer: anatomy and staging -- Colon cancer: management of locoregional disease -- Rectal cancer: management of locoreginal disease -- Systemic therapy for metastatic colorectal cancer -- Colorectal cancer: surgery and local ablation of liver metasteses -- Anal canal cancer -- Neuroendocrine tumors of the gastrointestinal tract -- Lymphomas of the gastrointestinal tract -- Gastrointestinal stromal tumors -- Small bowel cancers -- Cancer of unknown primary site -- Malignant peritoneal mesothelioma.
  • Pt. I. General information -- Epidemiology and etiology of breast cancer -- Staging of breast cancer -- Molecular classification -- Prognostic and predictive factors -- Mechanisms of resistance to radiation -- Interaction of chemotherapy, radiotherapy, and timing -- Interactions of radiotherapy with hormonotherapy -- pt. II. Therapeutic results of radiotherapy in breast cancer -- Ductal carcinoma in situ -- Early stage breast cancer -- Locally advanced breast cancer -- Metastatic breast cancer -- pt. III. Radiotherapy atlas in breast cancer -- The organs at risk and radiation tolerance doses -- Chest wall and regional lymphatics -- Breast and tumor bed -- pt. IV. Modern radiotherapy techniques in breast cancer -- Simulation and patient fixation methods -- Three-dimensional planning techniques -- Inverse planning, intensity modulated radiation therapy, and image-guided radiation therapy -- Forward planning intensity modulated radiation therapy techniques -- Boost techniques -- Quality assurance -- Partial breast irradiation -- Hypofractionation -- Application of tomotherapy in breast cancer patients -- pt. V. Radiotherapy complications in breast cancer -- Radiotherapy complications.
  • Difficult pain syndromes: neuropathic pain, bone pain, and visceral pain -- Opioid pharmacotherapy -- Nonpharmacologic management of pain -- Interventional approaches to pain -- Pathology of bone metastases-implications for treatment -- Pathophysiology of chemotherapy-induced peripheral neuropathy -- Cancer-related fatigue -- Fever and sweats -- Hot flashes -- Anorexia/weight loss -- Dysphagia/speech rehabilitation in palliative care -- Chemotherapy-related nausea and vomiting and treatment-related nausea and vomiting -- Assessment of management of chronic nausea and vomiting -- Diarrhea, malabsorption, and constipation -- Bowel obstruction -- Diagnosis and management of effusions -- Hiccups and other gastrointestinal symptoms -- Biology of treatment-induced mucositis -- Oral manifestations and complications of cancer therapy -- Approach to liver metastases in palliative oncology -- Palliative endoscope procedures -- Palliative interventional radiologic procedures -- Pruritus -- Treatment of tumor-related skin disorders -- Dermatologic adverse events during treatment -- Management of pressure ulcers and fungating wounds -- Lymphedema -- Principles of fistula and stoma management -- Dyspnea in the cancer patient -- Hemoptysis, airway obstruction, bronchospasm, cough, and pulmonary complications/symptoms of cancer and its treatment -- Prevention, assessment, and management of treatment-induced cardiac disease in cancer patients -- Management of hypercoagulable states and coagulopathy -- Urologic issues in palliative care -- Impact of hepatic and renal dysfunction on pharmacology of palliative care drugs -- Hypercalcemia -- Metabolic disorders in the cancer patient -- Infectious complications/management -- Management of intracranial metastases -- Management of spinal cord and cauda equina compression -- Recognizing and managing delirium -- Treating depression at the end of life -- Anxiety -- Cognitive decline following cancer treatment -- Substance-abuse issues in palliative care -- Epidemiology and prognostication in advanced cancer -- Hospice -- Cultural issues -- Communication during transitions of care -- The family meetings -- Psychosocial consequences of advanced cancer -- Disorders of sexuality and reproduction -- Caregiving in the home -- Management of symptoms in the actively dying patient -- Spirituality -- Bereavement care -- Staff stress and burnout -- Advance directives, decision making, and withholding and withdrawing treatment -- Palliative care: ethics and the law -- Hematologic support of the cancer patient -- Issues in nutrition and hydration -- Complementary, alternative, and integrative therapies in oncology -- Geriatric palliative care -- Palliative care in pediatrics -- Hematopoietic stem cell transplantation and supportive care -- Long-term survivorship: late effects -- Survivorship issues in adults -- Outcomes assessment in palliative care -- Measurement of quality of life outcomes -- Research issues: ethics and study design.
  • Basic biostatistics for the clinical trialist / Elizabeth G. Hill and Elizabeth Garrett-Mayer -- Fundamental concepts in clinical pharmacology / Daniel L. Gustafson and Erica L. Bradshaw-Pierce -- Bioanalycial methods in clinical drug development / Walter J. Loos, Peter de Bruijn and Alex Sparreboom -- Preclinical models for anticancer drug development / Edward A. Sausville -- Phase I clinical trials with anticancer agents / Stephen Leong ... [et al.] -- Phase II trials with anticancer agents / Hui K. Gan, J. Jack Lee and Lillian L. Siu -- Phase III clinical trials with anticancer agents / Wendy R. Parulekar and Daniel J. Sargent -- Pharmacokinetic studies in early anticancer drug development / Alex Sparreboom and Sharyn D. Baker -- Pharmacodynamic studies in early phase drug development / D. Ross Camidge, Robert C. Doebele and Antonio Jimeno -- Prediction of antitumor response / Fred R. Hirsch and Yu Shyr -- Imaging studies in anticancer drug development / David A. Mankoff -- Role of the U.S. Food and Drug Administration in cancer drug development / Ann T. Farrell, Ramzi N. Dagher and Richard Pazdur -- Early clinical trials with cytotoxic agents / M.J.A. de Jonge and Jaap Verweij -- Challenges and successes in developing effective anti-angiogenic agents / Laura Q.M. Chow and S. Gail Eckhardt -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Cancer chemoprevention / Christopher H. Lieu, William N. William Jr. and Scott Lippman -- Combined modality therapy in cancer management / David Raben and Kyle Rusthoven -- Cancer vaccines / Daniel Laheru -- Optimising the development of antibodies as treatment for cancer / Craig P. Carden, Hendrik-Tobias Arkenau and Johann S. de Bono -- Oligonucleotide therapeutics / Cy A. Stein, Britta Hoehn and John Rossi -- Anticancer drug development in pediatric patients / Lia Gore and Margaret Macy -- Clinical trials in special populations / S. Percy Ivy ... [et al.] -- NCI-sponsored clinical trials / Andriana Papaconstantinou and Janet E. Dancey.
  • Cancer biotherapy : general principles / Robert K. Oldham -- The pathogenesis of cancer metastasis : relevance to therapy / Sun-Jin Kim ... [et al.] -- Developmental therapeutics and the design of clinical trials / Robert K. Oldham -- Recombinant proteins and gnomics in cancer therapy / Kapil Mehta ... [et al.] -- Current concepts in immunology / Robert K. Oldham -- Therapeutic approaches to cancer-associated immune suppression / Robert K. Oldham -- Cancer vaccines / Kenneth A. Foon and Malek M. Safa -- Cytokines / Walter M. Lewko and Robert K. Oldham -- Interferons : therapy for cancer / David Goldstein ... [et al.] -- Monoclonal antibody therapy / Robert O. Dillman -- Immunotoxins / Arthur E. Frankel, Jung-Hee Woo, and David M. Neville -- Drug immunoconjugates / Malek Safa, Kenneth A. Foon, and Robert K. Oldham -- Targeted radionuclide therpy of cancer / John M. Pagel ... [et al.] -- Stem cell/bone marrow transplantation as biotherapy / Robert K. Oldham -- Cellular immunotherapy (CI), where have we been and where are we going? / John R.Yanelli -- Growth and differentiation factors as cancer therapeutics / Kapil Mehta, Robert K. Oldham, and Bulent Ozpolat -- Granulocyte colony-stimulating factor : biology and clinical potential / MaryAnn Foote and George Morstyn -- Granulocyte-macrophage colony-stimulating factor / MaryAnn Foote and George Morstyn -- Cancer gene therapy / Donald J. Buchsbaum ... [et al.] -- Regulatory process for approval of biologicals for cancer therapy / Antonio J. Grillo-López -- Cancer biotherapy : 2009 disease-related activity / Robert K. Oldham and Robert O. Dillman -- Biological therapy of melanoma / Robert K. Oldham -- Biological therapy of genitourinary cancer / Robert K. Oldham -- Biological therapy of colon cancer / Robert O. Dillman -- Biological therapy of breast cancer / Robert O. Dillman -- Biological therapy of lung cancer / Robert O. Dillman -- Biological therapy of B and T cell lymphoproliferative disorders / Robert O. Dillman -- Biological therapy of multiple myeloma / Robert K. Oldham -- Biological therapy of squamous cell cancers of the head and neck / Robert O. Dillman -- Biological therapy of glioblastoma / Robert O. Dillman -- Speculations for 2009 and beyond / Robert K. Oldham.
  • Plastic surgery: a component in the comprehensive care of cancer patients -- The principles of cancer reconstruction -- Breast reconstruction: timing and coordination with adjuvant therapy -- Breast reconstruction: autogenous tissue -- Breast reconstruction: implant and nipple reconstruction -- Skin cancer and reconstruction -- Lip, cheek, and scalp reconstruction -- Reconstruction of mandible, maxilla, and skull base -- Pharynx, cervical esophagus, and oral cavity reconstruction -- Concepts in nasal reconstruction -- Extremity reconstruction -- Abdominal wall tumors and their reconstruction -- Reconstruction of the intra-abdominal pelvis and the perineum -- Management of chemotherapeutic agent extravasation and radiation therapy adverse effects.
  • Basic Principles of Cancer Genetics / Leif W. Ellisen and Daniel A. Haber -- Principles of Cancer Genetic Counseling and Genetic Testing / Kristen M. Shannon and Devanshi Patel -- Genetics of Hereditary Breast Cancer / Paula D. Ryan -- Surgical Management of Hereditary Breast and Ovarian Cancer / Michelle C. Specht, Marcela G. del Carmen and Barbara L. Smith -- Hereditary Colon Cancer: Colonic Polyposis Syndromes / Andrew T. Chan and Daniel C. Chung -- Hereditary Colon Cancer: Lynch Syndrome / Eunice L. Kwak and Daniel C. Chung -- Hereditary Pancreatic Cancer / Janivette Alsina and Sarah P. Thayer -- Hereditary Diffuse Gastric Cancer / Prakash K. Pandalai and Sam S. Yoon -- Familial Renal Cell Cancers and Pheochromocytomas / Gayun Chan-Smutko and Othon Iliopoulos -- Familial Atypical Mole Melanoma (FAMM) Syndrome / Elizabeth D. Chao, Michele J. Gabree and Hensin Tsao -- Multiple Endocrine Neoplasia / Yariv J. Houvras and Gilbert H. Daniels -- Pediatric Malignancies: Retinoblastoma and Wilms' Tumor / David A. Sweetser and Eric F. Grabowski -- Neurofibromatosis and Schwannomatosis / Miriam J. Smith and Scott R. Plotkin -- The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles / Edwin Choy and David Altshuler -- Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer) / Alice T. Shaw, Eyal C. Attar, Edwin Choy and Jeffrey Engelman.
  • Section I. Introduction of cancer biology and cancer genetics -- Section II. Molecular techniques -- Section III. Molecular tests and cancer management -- Section IV. Molecular diagnostics of common malignancies -- Section V. Molecular basis of cancer therapeutics -- Section VI. Personalized medicine and targeted therapy of cancer -- Section VII. Future of molecular diagnostics and personalized cancer medicine.
  • Selecting the right targets for cancer therapy / Miguel H. Bronchud -- Clinical importance of prognostic factors: moving from scientifically interesting to clinically useful / N. Lynn Henry and Daniel F. Hayes -- Genetic markers in sporadic tumors / Elena Tamborini ... [et al.] -- Genetic markers in breast tumors with hereditary predisposition / Tatyana A. Grushko and Olufunmilayo I. Olopade -- Circulating tumor markers / Alan Horwich and Gill Ross -- Antibody-based proteomics analysis of tumor cell signaling pathways / Steven Pelech and Hong Zhang -- Gene expression arrays for pathway analysis in cancer research / Xiang Sean Yu ... [et al.] -- Signaling pathways in cancer / Daniel Kalderon -- Estrogen receptor pathways and breast cancer / Jing Peng and V. Craig Jordan -- Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics / Marcos Malumbres -- Angiogenesis switch pathways / Jaume Piulats and Francesc Mitjans -- Apoptosis pathways and new anticancer agents / Frank A.E. Kruyt, Jose A. Rodriguez, and Giuseppe Giaccone -- Genomic instability, DNA repair pathways and cancer / Gabriel Capellá, Josep Balart, and Miquel Angel Peinado -- Epigenomics and cancer / Isabel Lopéz de Silanes and Manel Esteller -- Harnessing the power of immunity to battle cancer: Much ado about nothing or All's well that ends well? / Angelo A. Cardoso -- Aurora Kinases: a new target for anticancer drug development / Teresa Macarulla, Francisco Javier Ramos, and Josep Tabernero -- Emerging molecular therapies: drugs interfering with signal transduction pathways / Alison H.M. Reid, Richard Baird, and Paul Workman -- Suicide gene therapy / Silke Schepelmann, Ion Niculescu-Duvaz, and Caroline J. Springer -- Genotypes that predict toxicity and genotypes that predict efficacy of anticancer drugs / Rosario García-Campelo ... [et al.] -- A personal account of the chemoprevention of breast cancer: possible or not possible? / V. Craig Jordan.
  • Cell death : history and future / Zahra Zakeri and Richard A. Lockshin -- Caspase mechanisms / Guy S. Salvesen and Stefan J. Riedl -- The mitochondrial death pathway / Anas Chalah and Roya Khosravi-Far -- Apoptotic pathways in tumor progression and therapy / Armelle Melet ... [et al.] -- Therapeutic targeting of death pathways in cancer : mechanisms for activating cell death in cancer cells / Ting-Ting Tan and Eileen White -- Overcoming resistance to apoptosis in cnacer therapy / Peter Hersey, Xu Dong Zhang, and Nizar Mhaidat -- Trail receptors : targets for cancer therapy / Robin C. Humphreys and Wendy Halpern -- Rational design of therapeutics targeting the BCL-2 family : are some cancer cells primed for death but waiting for a final push? / Victoria Del Gaizo Moore and Anthony Letai -- Autophagy and tumor suppression : recent advancesin understanding the link between autophagic cell death pathways and tumor development / Shani Bialik and Adi Kimchi -- Regulation of programmed cell death by the P53 pathway / Kageaki Kuribayashi and Wafik S. El-Deiry -- Regulation of programmed cell death by NF-[kappa]B and its role in tumorigenesis and therapy / Yongjun Fan ... [et al.] -- Targeting proteasomes as therapy in multiple myeloma / Dharminer Chauhan, Teru Hideshima, and Kenneth C. Anderson -- Histone deacetylase inhibitors : mechanisms and clinical significance in cancer : HDAC inhibitor-induced apoptosis / Sharmila Shankar and Rakesh K. Srivastava -- RNA interference and cancer : endogenous pathways and therapeutic approaches / Derek M. Dykxhoorn, Dipanjan Chowdhury, and Judy Lieberman -- Cancer stem cells and impaired apoptosis / Zainab Jagani and Roya Khosravi-Far.
  • Progress in tumor research v. 41-, 2014-
  • Clinical features of progressive neuroblastoma / Simon, T. -- DNA copy number changes and beyond / Fieuw, A.; Schulte, J.; De Preter, K.; Speleman, F. -- Genomic alterations and abnormal cell cycle in high-risk neuroblastoma / Capasso, M.; Sidarovich, V.; Quattrone, A.; Tonini, G.P. -- MYCN and microRNAs / Althoff, K.; Schulte, J.H. -- MYCN and its posttranslational regulation in neuroblastoma / Otto, T. -- Neuroblastoma and the P53 pathway / Chen, L.; Tweddle, D.A. -- Targeting cell death pathways in neuroblastoma / Fulda, S. -- Neuroblastoma and angiogenesis / Russler, J. -- The role of the anaplastic lymphoma kinase receptor in neuroblastoma / Yeung, C.M.; George, R.E. -- Molecular-targeted therapy in refractory or relapsed neuroblastoma / Corbacioglu, S. -- Immune regulation in neuroblastoma / Fest, S.; Starke, S. -- Approaches to passive and active vaccination against neuroblastoma / Lode, H.N. -- Role of cell therapy in neuroblastoma / Bremm, M.; Brehm, C.; Huenecke, S.; Rettinger, E.; Bader, P. -- Minimal residual disease in neuroblastoma / Weber, A.
  • Virology and pathogenesis / Pfister, H. -- Epidemiology of mucosotropic papillomaviruses / Gissmann, L. -- Condylomata acuminata / Gross, G. -- Recurrent respiratory papillomatosis / Wittekindt, C.; Wagner, S.; Klussmann, J.P. -- Cervical cancer and intraepithelial neoplasia / Schneider, A. ... [et al.] -- Cancer and intraepithelial neoplasia of the vulva and vagina / Petry, K.U. -- Penile cancer and penile intraepithelial neoplasia / Gross, G. -- Anal cancer and intraepithelial neoplasia / Wieland, U. ; Kreuter, A. -- Tonsillar cancer / Klussmann, J.P.; Wagner, S.; Wittekindt, C. -- Cytology / Ikenberg, H. -- Concepts of biomarker development / von Knebel Doeberitz, M.; Vinokurova, S.; Reuschenbach, M. -- Detection of human papillomavirus DNA and RNA / Ikenberg, H. -- Human papillomavirus testing in primary screening for cervical cancer / Petry, K.U. -- Primary prevention by vaccination / Kaufmann, A.M.; Gissmann, L.
  • Mechanistic aspects of COX-2 expression in colorectal neoplasia -- Mode of action of aspirin as a chemopreventive agent -- Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials -- COX-2 active agents in the chemoprevention of colorectal cancer -- New NSAID targets and derivatives for colorectal cancer chemoprevention -- Aspirin in prevention of sporadic colorectal cancer: current clinical evidence and overall balance of risks and benefits -- Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia -- Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC).
  • Defining the problem : from subclinical disease to clinically insignificant prostate cancer / Wael Sakr -- What every patient should know about prostate cancer before he submits to biopsy of his prostate / Thomas A. Stamey, Rosalie Nolley, and Dorothea Torti -- Prostate-specific antigen and prostate cancer screening / Stacy Loeb, Misop Han, and William J. Catalona -- The role of complexed prostate-specific antigen in prostate cancer screening / Matthew E. Nielsen and Alan W. Partin -- Newly recognized forms of prostate-specific antigen and emerging molecular markers / Eduardo I. Canto and Kevin M. Slawin -- The role of prostate-specific antigen velocity in the diagnosis and management of prostate cancer / H. Ballentine Carter -- Prostate cancer screening : navigating the controversy / Timothy C. Brand and Ian M. Thompson -- Prostate cancer nomograms and how they measure up to neural networks / Pierre I. Karakiewicz and Michael W. Kattan -- Preparation for prostate biopsy / Alan M. Nieder and Mark S. Soloway -- Principles of prostate ultrasound / Martha K. Terris -- Minimizing pain and optimizing patient experience during prostate biopsy / J. Stephen Jones -- Prostate biopsy techniques / Katsuto Shinohara -- Biopsy strategies-how many and where? / Joseph C. Presti, Jr. -- Transperineal prostate biopsy / Paolo Emiliozzi and Vito Pansadoro -- Repeat prostate biopsies and the Vienna nomograms / Bob Djavan and Sibylle Marihart -- Saturation biopsy for detection and characterization of prostate cancer / J. Stephen Jones -- Pathologic implications of prostate biopsy / Ming Zhou and Cristina Magi-Galluzzi -- Complications of transrectal ultrasound-guided prostate biopsy / Sam S. Chang and Michael S. Cookson -- Management and controversies of high-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation on prostate biopsy / Alon Z. Weizer ... [et al.] -- Future directions in prostate cancer diagnosis / Nicholas J. Fitzsimons ... [et al.]
  • Anatomy and Normal Histology of the Prostate Pertinent to Biopsy Practice -- Prostate Needle Biopsy Sampling Techniques: Impact on Pathological Diagnosis -- Diagnosis of Limited Cancer in Prostate Biopsy -- Immunohistochemistry in Prostate Biopsy Evaluation -- Contemporary Approach to Gleason Grading of Prostate Cancer -- Histologic Variants of Prostate Carcinoma -- Benign Mimics of Prostate Carcinoma -- Atypical Cribriform Lesions of the Prostate Gland: Emerging Concepts of Intraductal Carcinoma of the Prostate (IDC-P) -- High-Grade Prostatic Intraepithelial Neoplasia -- Atypical Glands Suspicious for Cancer -- Spindle Cell Lesions of the Prostate Gland -- Treatment Effect in Benign and Malignant Prostate Tissue -- Molecular Biology of Prostate Cancer and Emerging Diagnostic and Prognostic Biomarkers -- Biopsy Specimen Handling, Processing, Quality Assurance Program -- Reporting of Prostate Biopsy.
  • Prostate cancer 2010
    Each volume in the Early Detection and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You'll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for prostate cancer. Apply expert advice on the best "next-step" plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered.
  • Prostate cancer 2007
  • Cell biology. Stem cells in the normal and malignant prostate / Norman J. Maitland -- Role of reactive stroma in prostate cancer / Rebeca San Martin, David R. Rowley -- The role of cholesterol in prostate cancer / Keith R. Solomon, Kristine Pelton, Michael R. Freeman -- Genetics. PTEN in prostate cancer / Marcus A. Ruscetti, Hong Wu -- ETS fusion genes in prostate cancer / J. Chad Brenner, Arul M. Chinnaiyan, Scott A. Tomlins -- Cell signaling. Signaling mechanisms of Vav3, a guanine nucleotide exchange factor and androgen receptor coactivator, in physiology and prostate cancer progression / Leah S. Lyons, Kerry L. Burnstein -- Transforming growth factor-beta in prostate cancer / David Danielpour -- The p38 MAPK pathway in prostate cancer / Daniel Djakiew -- NF-kappaB2/p52 in prostate cancer / Nagalakshmi Nadiminty, Ramakumar Tummala, Yezi Zhu -- The functional role of DAB2IP, a homeostatic factor, in prostate cancer / Eun-Jin Yun, Kaijie Wu, Yuh-Shyan Tsai -- Tyrosine kinases in prostate cancer / Yun Qiu, Dhanraj Deshmukh -- Human prostatic acid phosphatase in prostate carcinogenesis / Sakthivel Muniyan, Yu-Wei Chou, Shou-Qiang Ou-Yang -- Hormonal. Truncated androgen receptor splice variants in prostate cancer / Peter E. Lonergan, Donald J. Tindall -- Biology and clinical relevance of estrogen receptors in prostate cancer / Shuk-Mei Ho, Pheruza Tarapore, Ming-Tsung Lee, and Yuet-Kin Leung -- Vitamin D and prostate cancer / Jung-Sun Kim, Justin M. Roberts, Nancy L. Weigel -- HDAC6 regulation of androgen signaling in prostate cancer / Junkui Ai, Zhou Wang -- Beyond the cell cycle : implications of D-type cyclin deregulation in prostate cancer / Michael A. Augello, William F. Ostrander Jr., Karen E. Knudsen -- Cell death. Role of par-4 in prostate cancer / Nidhi Shukla, Nikhil K. Hebbar, Vivek M. Rangnekar -- Autophagy and prostate cancer therapeutics / Hsing-Jien Kung, Chun Changou, Hao G. Nguyen, Joy C. Yang, Christopher P. Evans, Richard J. Bold, and Frank Chuang.
  • Xenograft models of human prostate cancer -- The pathology of human prostatic atrophy and inflammation -- Tissue microarrays in prostate cancer research -- Prostate (cancer) stem cells -- Cancer-host interactions: a paradigm shift brings new understanding and new opportunities -- Androgen receptor function in prostate cancer progression -- Hedgehog signaling in development and cancer -- Cholesterol, cell signaling, and prostate cancer -- Gene therapy for advanced prostate cancer -- Role of transforming growth factor-ss in immunotherapy of prostate cancer -- Biology and therapeutic basis of prostate cancer bone metastasis -- Molecular imaging: noninvasive strategies to visualize gene expression in living subjects -- Quantum dot nanotechnology for prostate cancer research -- Expression profiling of prostate cancer progression -- Somatic alterations in prostate cancer progression -- Linkage studies of prostate cancer families to identify susceptibility genes -- Somatic DNA methylation changes and prostatic carcinogenesis -- Telomeres, telomerase, chromosome stability, and prostate cancer -- Racial differences in prostate cancer mortality -- Radiotherapy for the treatment of locally advanced prostate cancer -- Recombinant antibody candidates for treatment of prostate cancer -- Differentiation agents and epigenomic therapies: an overview and potential use for prostate cancer -- Taxane-based chemotherapy for prostate cancer -- Co-targeting therapeutics for hormone refractory prostate cancer -- Intercellular targets of prostate cancer -- Novel and efficient translational clinical trial designs in advanced prostate cancer.
  • Based on the highly successful first edition of Prostate Biopsy: Indications, Techniques, and Complications, this new volume presents new concepts that have emerged in answer to current questions from its audience. Many new perspectives and technologies are presented, many from the authors' internationally recognized work on the topic. Substantial developments in techniques and complications are explored in detail. The chapter authors comprise a complete spectrum of specialists in their respective subject areas. All authors are internationally accepted as the premier authorities on their chosen topics. Prostate Cancer Diagnosis: PSA, Biopsy, and Beyond presents new data on the controversial issue of PSA screening and thresholds as indication to perform biopsy. Office based transrectal saturation biopsy is covered in detail. Other topics explored include template guided biopsy and image-guided biopsy as well as a completely new paradigm for prevention of complications.Prostate Cancer Diagnosis: PSA, Biopsy, and Beyond will be of great value and utility to all practicing urologists.
  • Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals, and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely. A wide range of topics are covered by leading authorities in the field. The biology and natural history of prostate cancer are reviewed, and the role of lifestyle and dietary factors, assessed. Detailed attention is paid to risk prediction biomarkers and to the role of novel high-throughput nucleic acid-based technologies in improving risk prediction and thereby allowing tailored approaches to cancer prevention. Potential means of chemoprevention of prostate cancer are also reviewed in depth, covering the very positive new data on the impact of aspirin as well as evidence regarding 5-reductase inhibitors, DFMO, and lycopene. Guidance is provided on the differentiation of aggressive from indolent disease, and the policy and research implications of recent findings are examined. This book will be of interest to both clinicians and researchers.
  • Histopathology and molecular biology of prostate atrophy: a lesion associated with inflammation, prostate intraepithelial neoplasia, and prostate cancer -- Epigenetic gene silencing in prostate cancer -- Inherited genetic changes in prostate cancer -- Prostate molecular oncogenesis: gene deletions and somatic mutations -- Somatic genetic changes in prostate cancer: androgen receptor alterations -- Androgen receptor in prostate cancer progression -- Epigenetic modification and aceylation of androgen receptor regulate prostate cellular growth -- Estrogen receptor a [alpha] and b [beta] in the regulation of normal and malignant prostate epithelium -- Estrogen action in normal prostate epithelium and in prostate cancer -- Hypoxia-inducible factor 1 in the angiogenesis of prostate cancer -- Signal transduction by the Ras-MAP kinase pathway in prostate cancer progression -- Transcription factors STAT5 and STAT3: survival factors for prostate cancer cells -- Role of P13K-Akt and PTEN in the growth and progression of prostate cancer -- New perspectives in prediction of clinical outcome of prostate cancer; TMPRSS2-ETS gene fusion in prostate cancer -- New directions in radiation therapy of prostate cancer: brachytherapy and intensity-modulated radiation therapy -- The current knowledge of hormonal therapy in the treatment of prostate cancer -- Advances in surgical intervention of porstate cancer: comparison of the benefits and pitfalls of retropubic, perineal, and laparoscopic radical prostatectormy -- Targeted therapy trials for prostate cancer -- New perspectives on chemotherapy in prostate cancer -- Concluding remarks: the future of prostate cancer.
  • Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which neatly resolves this problem. It covers relevant literature by leading experts in basic science, molecular biology, epidemiology, cancer prevention, cellular imaging, staging, treatment, targeted therapeutics and innovative technologies. Prostate Cancer: A Comprehensive Perspective, is a valuable and timely resource for urologists and oncologists.
  • 1. Introduction -- 2. An Appointment with the Urologist -- 3. Prostate-Specific Antigen (PSA) -- 4. Prostate Biopsy -- 5. Prostatitis- Pelvic Pain -- 6. Benign Prostatic Hyperplasia -- 7. Prostate Cancer -- 8. How to Get a Second Opinion.
  • The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance. The volume will cover the latest innovative researches in prostate cancer, with particular emphasis to the state-of-the-art analysis technologies that are essential for the accurate identification of molecular targets for disease diagnosis, molecular mechanisms of tumorigenesis, markers for susceptibility, molecular-based prognostic prevision, characterization of biomarkers of drug efficacy and drug resistance, validation of new therapeutics and diagnostics. Current advancements on the intersecting data concerning transcriptomes, proteomes, and the molecular techniques referred as "omes, will be reported and discussed.
  • Introduction -- History of Prostate Ultrasound -- Applied Anatomy of the Male Pelvis -- Basic Physics of Diagnostic Ultrasound -- Advanced Prostate Imaging: Correlating Prostate Anatomy with MRI and MRI/Ultrasound Fusion -- Prostate Ultrasound Artifacts and How to Fix Them -- Male Infertility And Prostate Ultrasound -- Application of Prostate Ultrasound for Benign Prostate Hyperplasia and Male Urinary Stress Incontinence -- Application of Prostate Ultrasound for Prostate Biopsy -- Prostate Ultrasound Complications and Patient Safety -- Imaging the Prostate with Quantitative Ultrasound: Implications for Guiding Biopsies, Targeting Focal Treatment, and Monitoring Therapy -- Prostate Elastography.
  • 1. Delineating protease functions during cancer development / Nesrine I. Affara, Pauline Andreu, and Lisa M. Coussens -- 2. Proteolytic systems: constructing degradomes / Gonzalo R. Ordóñez ... [et al.] -- 3. Microarrays for protease detection in tissues and cells / Kamiar Moin ... [et al.] -- 4. Positional scanning synthetic combinatorial libraries for substrate profiling / Eric L. Schneider and Charles S. Craik -- 5. Mixture-based peptide libraries for identifying protease cleavage motifs / Benjamin E. Turk -- 6. High throughput substrate phage display for protease profiling / Boris Ratnikov, Piotr Cieplak, and Jeffrey W. Smith -- 7. Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins / John P. Hobson ... [et al.] -- 8. Cell-based identification of natural substrates and cleavage-sites for extracellular proteases by SILAC proteomics / Magda Gioia, Leonard J. Foster, and Christopher M. Overall -- 9. Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activity -- J. Oliver McIntyre and Lynn M. Matrisian -- 10. Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin / Shihui Liu ... [et al.] -- 11. On-demand cleavable linkers for radioimmunotherapy / Pappanaicken R. Kumaresan, Juntao Luo, and Kit S. Lam.
  • Protein kinase C in cancer signaling and therapy: introduction and historical perspective -- Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids -- Phorbol esters and diacylglycerol: the PKC activators -- Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals -- Regulation of PKC by protein-protein interaction in cancer -- Introduction: PKC isozymes in the control of cell function -- Regulation and function of protein kinase C signaling -- PKC and control of the cell cycle -- PKC and the control of apoptosis -- Atypical PKC's, NF-kB and inflammation -- Introduction: PKC and cancer -- Protein kinase C, p53, and DNA damage -- PKCs as mediators of the hedgehog and Wnt signaling pathways -- PKC-PKD interplay in cancer -- Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the development of squamous cell carcinoma, a nonmelanoma human skin cancer -- PKC isozymes and skin cancer -- PKC and breast cancer -- PKC and prostate cancer -- Protein kinase C and lung cancer -- Introduction [PKC isozymes as targets for cancer therapy] -- PKC and resistance to chemotherapeutic agents -- PKCd as a target for chemotherapeutic drugs -- Atypical PKCs as targets for cancer therapy.
  • Protein tyrosine kinases as targets for cancer and other indications / Mark Pearson, Carlos Garcia-Echeverria, Doriano Fabbro -- Inhibitors of signaling interfaces: targeting Src homology 2 domains in drug discovery / Carlos Garcia-Echeverria -- PI 3-kinase inhibition: a target for therapeutic intervention / Peter M. Finan, Stephen G. Ward -- Src as a target for pharmaceutical intervention: potential and limitations / Mira Susa ... [et al.] -- Activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia / Blanca Scheijen, James D. Griffin -- JAK kinases in leukemias/lymphomas and multiple myeloma / Renate Burger, Martin Gramatzki -- Glivec (Gleevec, Imatinib, STI571): a targeted therapy for CML / Elisabeth Buchdunger, Renaud Capedeville -- Platelet-derived growth factor: normal function, role in disease, and applications of PDGF antagonists / Tobias Sjoblom ... [et al.] -- Structural biology of protein tyrosine kinases / Sandra W. Cowan-Jacob ... [et al.] -- Testing of signal transduction inhibitors in animal models of cancer / Terence O'Reilly, Robert Cozens -- Phosphoproteomics in drug discovery and development / Michel F. Moran.
  • While radiation therapy is a mainstay of cancer treatment, traditional linear accelerators mainly use photons to irradiate cancerous tissue. Photons deposit much more energy in the surrounding normal tissue than protons. Proton beam therapy is a revolutionary alternative that deposits most of its cancer-killing energy within the area of the tumor, thereby potentially improving cure rates and reducing side effects in properly selected patients. This book guides the reader through existing evidence supporting proton beam therapy for an increasing number of patients and conditions, including pediatric, prostate, and lung cancer, mediastinal tumors, skull base tumors, conditions of the eye, and sarcomas.
  • Psycho-oncology 2014
    Psycho-oncology is a thriving discipline in cancer care, and numerous research activities have been undertaken in the endeavor to improve treatment outcomes and to gain a better understanding of the psychological consequences of cancer. This book presents and discusses the latest findings from science and practice for a broad range of psychological and social issues related to cancer and its treatments. Not only are general psychosocial impacts of cancer described, but the very common fear of progression is elucidated. The relevance of psychooncology at different stages of disease (during oncological treatment, in rehabilitation, and during palliative care) is explained, and various psychooncological interventions are illustrated. Other important topics are the experience of being a cancer survivor, who may be cured but not be healthy, the psychological burden on relatives, and gender differences in coping with cancer. Quality of life and patient-reported outcomes are also commented on since they are among the key benchmarks for successful coping with the diagnosis of cancer, its treatment, and its late effects.
  • Psychoneuroimmunology and cancer : incidence, progression, and quality of life -- Inflammation, chronic disease, and cancer : is psychological distress the common thread? -- Psychological aspects of hereditary cancer risk counseling and genetic testing -- Mastectomy to prevent breast cancer : psychosocial aspects of women's decision-making -- Decision aids in advanced cancer -- Cancer fatalism : attitudes toward screening and care -- Positive psychology perspectives across the cancer continuum : meaning, spirituality, and growth -- Stress, coping, and hope -- Religiousness and spirituality in coping with cancer -- Controversies in psycho-oncology -- Psychosocial interventions for couples coping with cancer : a systematic review -- The impact of cancer and its therapies on body image and sexuality -- Cancer caregivership -- Psychosocial interventions in cancer -- Quality of life -- Exercise for cancer patients : treatment of side effects and quality of life -- Use of the classic hallucinogen Psilocybin for treatment of existential distress associated with cancer -- The placebo and nocebo effects in cancer treatment -- Psychological factors and survivorship : a focus on post-treatment cancer survivors -- Complementary mind-body therapies in cancer -- End-of-life communication in cancer care -- The intersection between cancer and caregiver survivorship -- Resources for cancer patients -- Bringing it all together.
  • This practical manual presents the main drugs and protocols currently used in the psychopharmacological treatment of psychiatric disorders in cancer and palliative care settings and explores the principal issues involved in such treatment. Significant clinical challenges encountered in the psychopharmacological management of various psychiatric conditions are discussed, covering aspects such as side-effects and drug-drug interactions. Attention is also paid to the emerging theme of adjuvant use of psychotropic drugs for the treatment of symptoms or syndromes not primarily related to psychiatric disorders (e.g. pain, hot flashes). In addition, practical suggestions are provided for dealing with special populations, including children, the elderly, and people affected by severe mental illness. The book is designed to be easy to read and to reference: information is clearly displayed in concise tables and boxes, accompanied by further detail within the text and clinical vignettes. The authors include some of the most renowned clinicians working in the field of psycho-oncology.
  • Part I. Preamble and Introduction -- 1. Managing Patients with Hematological Malignancies for 25 Years / Benoit Schlemmer -- 2. Pulmonary Involvement in Patients with Hematological Malignancies / Élie Azoulay -- 3. Respiratory Infections in Patients with Hematological Malignancies / Ayman O. Soubani -- Part II. Epidemiology -- 4. Epidemiology of Respiratory Events in Patients with HM (Not Including ICU) / Georg Maschmeyer -- 5. Epidemiology of Acute Respiratory Failure in Patients with HM (ICU Only) / Carlos Agustí, Carmen Lucena, and Antoni Torres -- 6. Noninfectious Lung Involvement in Patients with Hematological Malignancies (Excluding BMT) / Bernard Maitre -- 7. Noninfectious Pulmonary Involvement in Hematopoietic Stem Cell or Bone Marrow Transplant Recipients / Bekele Afessa -- 8. Are There Any Pulmonary Issues Specifically Related to Cord Blood Transplants? / Jonathan Gutman -- 9. Cardiovascular Complications of Cancer Therapeutics / Aarif Y. Khakoo and Callie S. Kwartler -- 10. Prophylaxis: Peace of Mind? / Benoit Guery and Karine Faure -- Part III. Diagnostic Strategy in HM Patients -- 11. How Type of Malignancy and Treatment Assist in the Etiological Diagnosis / Alexandre Boyer and Didier Gruson -- 12. Contribution of Radiology in Patients with Hematological Malignancies and Pulmonary Involvement / Claus Peter Heussel -- 13. Is There Still a Place for Transbronchial Lung Biopsy or Other Lung Biopsy Techniques? / Christophe Dooms and Vincent Ninane -- 14. The Increasing Role for Core Needle Biopsy of Pulmonary Lesions in Immunocompromised Patients / Cédric de Bazelaire, Raphael Calmon, Marion Chapelier, Amélie Pluvinage, and Eric de Kerviler -- 15. Minimally Invasive Diagnostic Strategy in Immunocompromised Patients with Pulmonary Infiltrates / Laurent Camous, Virginie Lemiale, Achille Kouatchet, David Schnell, Sandra de Miranda, and Élie Azoulay -- 16. Pleural Effusions and Thoracentesis in Patients with Hematological Malignancies / Michael G. Alexandrakis, Paschalis Steiropoulos, and Demosthenes Bouros -- 17. Diagnostic Yield of BAL Fluid Cytology in Hematologic Malignancies / Jean-François Bernaudin and Jocelyne Fleury-Feith -- 18. New Methods for Bacterial Diagnosis in Patients with Hematological Malignancies / Agnès Ferroni and Jean-Ralph Zahar -- 19. FDG-PET Imaging in Haematological Patients with Pulmonary Infiltrates / Tomohiko Yamane -- 20. What Has Been Learned from Postmortem Studies? / Stephen M. Pastores, Alina O. Dulu, and Shilpa A. DeSouza -- Part IV. Lung Infections in Patients with HM --21. Common Viral Pneumonia / David Schnell, Jérôme Legoff, and Élie Azoulay -- 22. Emerging Viral Infections / Oliver Schildgen -- 23. Cytomegalovirus Pneumonia in Patients with Hematologic Malignancies / Karen J. Vigil and Roy F. Chemaly -- 24. Herpes Simplex Virus Pneumonia in Patients with Hematologic Malignancies / Jharna N. Shah and Roy F. Chemaly -- 25. Pneumocystis Pneumonia in Non-AIDS Immunocompromised Patients / Élie Azoulay, Virginie Lemiale, Achille Kouatchet, François Vincent, Antoine Roux, Guillaume Bollée, and Patricia Roux -- 26. Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases / Marie-Elisabeth Bougnoux, Fanny Lanternier, Emilie Catherinot, Felipe Suarez, and Olivier Lortholary -- 27. Emerging Fungal Infections / Marcia Garnica and Marcio Nucci -- 28. Candida Pneumonia in Patients with Hematological Neoplasia / Carlos Carvajal, Jordi Rello, and Jeffrey Lipman -- 29. Parasitic Lung Infections / Jean-François Timsit, Jean-Paul Brion, and Hervé Pelloux -- 30. Pulmonary Mycobacterial Infections in Patients with Hematological Malignancies / Khalid A. Al-Anazi and Asma M. Al-Jasser -- Part V. Noninfectious Pulmonary Involvement in Patients with HM -- 31. Pleuropulmonary Changes Induced by Drugs in Patients with Hematologic Diseases / Philippe Camus -- 32. Cardiovascular Complications of Cancer and Radiation Therapy / Callie S. Kwartler and Aarif Y. Khakoo -- 33. Diffuse Alveolar Hemorrhage in Hematopoietic Stem Cell Transplant Recipients and Patients with Hematologic Malignancy / Bekele Afessa -- 34. Venous Thromboembolism in Patients with Hematologic Malignancies / Tarek Sousou and Alok A. Khorana -- 35. Transfusion-Related Acute Lung Injury in Children with Hematological Malignancies / Rachel S. Bercovitz, J. Bradley Ball, Marguerite R. Kelher, and Christopher C. Silliman -- 36. Acute Respiratory Distress Syndrome (ARDS) in Neutropenic Patients / Mokart Djamel, Textoris Julien, Ettori Florence, Bruno Chetaille, and Blache Jean-Louis -- 37. Pulmonary Venoocclusive Disease Following Hematopoietic Stem Cell Transplantation / Matthew C. Bunte and Linda J. Burns -- 38. Radiation Pneumonitis / Miguel Gallego Díaz and Jordi Rello Condomines -- 39. Leukostasis, Infiltration and Pulmonary Lysis Syndrome Are the Three Patterns of Leukemic Pulmonary Infiltrates / François Vincent -- 40. Pulmonary MALT Lymphoma: Clinical, Molecular and Therapeutic Aspects / Marie Wislez, Raphael Borie, Catherine Thieblemont, Marie-France Carette, Martine Antoine, and Jacques Cadranel -- 41. ARDS During Neutropenia Recovery / Élie Azoulay, Eric Ezingeard, Choupi-Salomon Berckowski, and Michael Darmon -- 42. Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation / Huda Salman, Kenneth R. Cooke, and Hillard M. Lazarus -- Part VI. Treatment and Difficult Decisions in Patients with HM and ARF -- 43. Antibiotic Therapy in Neutropenic Patients / Matthieu Legrand, Adeline Max, and Bertrand Gachot -- 44. Antifungal Therapy in Patients with Hematological Malignancies / Raoul Herbrecht and Yasmine Nivoix -- 45. Antiviral Agents in Patients with Hematological Malignancies and Acute Respiratory Failure / Michael Sandherr -- 46. Mechanical Ventilation in Patients with Hematological Malignancies / Márcio Soares, Jorge I.F. Salluh, and Pieter O. Depuydt -- 47. Optimizing Noninvasive Ventilation in Hematological Patients with Acute Respiratory Failure / Gilles Hilbert -- 48. Noninvasive Ventilation to Ensure the Safety of Fiberoptic Bronchoscopy / Massimo Antonelli, Giuseppe Bello, and Riccardo Maviglia -- 49. NIV Outside the ICU / Stefano Nava and Sebastiano Mercadante -- 50. Palliative Noninvasive Mechanical Ventilation in Patients with Hematological Malignancies / Anne-Pascale Meert, Thierry Berghmans, and Jean-Paul Sculier -- 51. Acute Kidney Injury in Cancer Patients / Michael Darmon, Laurent Camous, Camille Devanlay, Emmanuel Canet, Benoit Schlemmer, and Fabrice Zeni -- 52. Septic Shock / David Grimaldi and Frédéric Pène -- 53. Prognostic Factors for Mortality in the Critically Ill Cancer Patient / Kathleen N.S. Cathcart and Jeffrey S. Groeger -- 54. Managing Critically Ill Cancer Patients: Another Medical Success Story / Élie Azoulay, Marcio Soares, Michael Darmon, Dominique Benoit, Stephen Pastores, and Bekele Afessa -- 55. Palliative Care and Dyspnea Management in Patients with Hematological Malignancies and Acute Respiratory Failure / Amy P. Abernethy, Jane L. Wheeler, and David C. Currow -- 56. End-of-Life Decisions in Cancer Patients / Lieve Van den Block, Agnes van der Heide, and Luc Deliens -- Part VII. Pearls That You Should be Aware Of -- 57. An Unexpected Diagnosis of Pulmonary Tuberculosis / Virginie Lemiale, A. Seguin, and Élie Azoulay -- 58. Respiratory Symptoms Occurring 4 Months After Allogeneic Hematopoietic Stem Cell Transplantation / Anne Bergeron, Séverine Feuillet, Véronique Meignin, Patricia Ribaud, and Abdellatif Tazi -- 59. Pulmonary Complications of Chronic Lymphocytic Leukemia / Melhem Solh and Punit Wadhwa -- 60. Clinical Pearls: Pulmonary Veno-occlusive Disease / Jonathan Gutman -- 61. Cytarabine-Induced Pulmonary Toxicity in Leukemic Patients / Fabio Forghieri, Leonardo Potenza, Monica Morselli, Monica Maccaferri, Giuseppe Torelli, and Mario Luppi -- 62. Histoplasmosis in a Patient with Chronic Myelogenous Leukemia / Vincent Peigne, Benoît Schlemmer, and Olivier Lortholary -- 63. Pulmonary Toxicity of Imatinib and Other BCR-ABL Tyrosine Kinase Inhibitors / François Vincent -- 64. Rituximab-Related Pulmonary Toxicity / Yair Herishanu, Chava Perry, and Aaron Polliack -- 65. Cardiogenic Causes of Respiratory Failure in Patients with Hematological Malignancies / Julien Maizel, Berengere Gruson, Jean-Pierre Marolleau, and Michel Slama -- 66. Pulmonary Alveolar Proteinosis / François Vincent, H. Tandjaoui, and P.Y. Brillet -- 67. Pneumocystis jiroveci Pneumonia in a Patient with Diffuse Large B-Cell Lymphoma / Hung Chang and Lee-Yung Shih -- 68. Pulmonary Infiltration in Anaplastic T-Cell Lymphoma / Christophe Cracco, Julien Mayaux, Sylvain Choquet, Catherine Beigelman, and Frédéric Charlotte -- 69. A Rapidly Reversible Cause of Pulmonary Embolism / Sophie Georgin-Lavialle, Élie Azoulay, Fabrice Zeni, and Michael Darmon -- 70. Hairy Cell Leukemia with Pulmonary Infiltrates / Virginie Lemiale, Véronique Meignin, and Élie Azoulay -- 71. Trichosporon asahii Infection in a Neutropenic Patient / Djamel Mokart, Antoine Sannini, Jean-Paul Brun, Laurent Chow-chine, and Jean-Louis Blache -- Part VIII. Post Face -- 72. Who Is This Book for? Reserved to Highly Specialized Teams? / Laurent Brochard -- 73. Pulmonary Involvement in Patients with Hematological Malignancies: And Now? / Patricia Ribaud and Gérard Socié.
  • This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a well-established cancer center in Texas, who pursued the goal of cure for breast cancer. The evolution of improved outcomes in the treatment of microscopic metastatic breast cancer is also the story of the development of adjuvant chemotherapy for post-operative breast disease. The adjuvant therapy of breast cancer came about with the realization that this malignancy, when diagnosed in most patients, had spread beyond the confines of the primary cancer.
  • Central Nervous System Tumors: Adult and Pediatric -- Skin Cancer -- Head and Neck Cancer -- Lung Cancer -- Tumors of the Mediastinum -- Breast Cancer -- Upper Gastrointestinal Cancers -- Lower Gastrointestinal Cancers -- Urinary System Cancers -- Male Genitourinary Cancer -- Gynecologic Malignancies -- Hematologic Malignancies -- Sarcoma -- Pediatric Non-central Nervous System Cancers -- Benign and Metastatic Disease.
  • Radiation Physics -- Radiobiology -- Clinical Radiation Oncology -- Central Nervous System Tumors -- Head and Neck Cancers -- Lung Cancer -- Breast Cancer -- Genitourinary System Cancers -- Gynecological Cancers -- Gastrointestinal System Cancers -- Soft Tissue Sarcoma -- Skin Cancer -- Lymphomas and Total Body Irradiation -- Pediatric Tumors -- Rare Tumors and Benign Diseases.
  • Ideal for on-the-spot consultation, this pocket manual, Radiation Oncology: Management Decisions, provides easily accessible information for residents and practitioners in radiation oncology. It presents the most essential information that is immediately required in the clinical setting. The first eight chapters of the book focus on key basic concepts; the remaining 46 chapters describe treatment regimens for all cancer sites and tumor types. Includes coverage of pain and palliation, and covers all latest therapeutic techniques. This edition includes expanded information on image-guided therapy, 3D techniques, and 4D protocols. The updated cancer staging guidelines have been used throughout the manual. In addition, there is a brand-new chapter devoted to QUANTEC dosage recommendations.
  • Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference.
  • This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. ℗ℓ Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.
  • History of radiation therapy in dermatology -- Radiobiology -- Physical aspects of dermatological radiotherapy -- Radiation protection -- Staging of squamous cell carcinoma and basal cell carcinoma -- Acute and chronic cutaneous reactions to radiotherapy -- Efficacy of superficial radiotherapy -- Treatment selection for superficial radiotherapy -- Superficial radiation therapy treatment planning -- Current use of dermatologic radiotherapy in the United States -- Grenz ray therapy -- Radiotherapy for cutaneous squamous and basal cell carcinomas -- Brachytherapy -- Cutaneous merkel cell carcinoma -- Radiotherapy for cutaneous angiosarcoma -- Radiotherapy for dermatofibrosarcoma protuberans -- Squamous and basal cell carcinomas with perineural invasion -- Getting started in superficial radiation for the dermatology practice.
  • Radical Prostatectomy: Surgical Perspectives provides surgeons with a comprehensive overview of the anatomical approach to radical prostatectomy, whether done through an open (retropubic) or robotic-assisted laparoscopic approach. All chapters are structured to provide a step-by-step approach to the most technically demanding and most common oncologic procedure in urology surgery. The book includes highly practical presentations of typical surgical patients seen in the clinical practice of urology and relies heavily on illustrations and intraoperative photographs to clearly complement the text. In addition, the book ?includes a detailed description of the management of uncommon but potentially serious intraoperative complications, including major vascular injury, ureteral transaction, and rectotomy. Written by authors from a variety of integrated disciplines, including anesthesia, cardiology, and nursing Radical Prostatectomy: Surgical Perspectives is a unique and valuable resource in the field of urology both for those currently in training and for those already in surgical practices.
  • Part I. Chemistry and Physics -- Radiopharmaceuticals for Radioguided Surgery / Esteban Obenaus, Paola A. Erba, Marco Chinol, Christophe Van de Wiele and Gyozo A. Janoki, et al. -- Physical Performance Parameters of Intraoperative Probes / Carlo Chiesa, Francesca Toscano, Mario Mariani and Emilio Bombardieri -- Positron-Sensitive Probes / Schlomo Schneebaum, Richard Essner and Einat Even-Sapir -- Gamma Ray Imaging Probes for Radioguided Surgery and Site-Directed Biopsy / Francesco Scopinaro and Alessandro Soluri -- Radiation Protection in Radioguided Surgery / Edwin C. Glass and Wendy A. Waddington -- Training and Credentialing for Radioguided Surgery / Eric D. Whitman -- Part II. Sentinel Lymph Nodes -- The Anatomy and Physiology of Lymphatic Circulation / Preya Ananthakrishnan, Giuliano Mariani, Luciano Moresco and Armando E. Giuliano -- The Role of Lymph Node Staging for Clinical Decision Making in Patients with Solid Cancers / Fausto Badellino, Ilaria Pastina, Elisa Borsò, Sergio Ricci and H. William Strauss, et al. -- Sentinel Lymph Node Biopsy in Patients with Breast Cancer / Charles E. Cox, John M. Cox, Giuliano Mariani, Caren E.G. Wilkie and Laura B. White, et al. -- Sentinel Lymph Node Biopsy in Cutaneous Melanoma / Jeffrey E. Gershenwald, Roger F. Uren, Giuliano Mariani and John F. Thompson -- Dynamic Sentinel Lymph Node Biopsy in Penile Carcinoma / Simon Horenblas, Bin K. Kroon, Renato A. Valdés Olmos and Omgo E. Nieweg -- Sentinel Lymph Node Biopsy in Cancer of the Head and Neck / Luca Calabrese, David Soutar, Jochen Werner, Roberto Bruschini and Concetta De Cicco, et al. -- Sentinel Lymph Node Biopsy in Gynecologic Malignancies / Emilio Bombardieri, Marco Maccauro, Rosanna Fontanelli, Francesco Raspagliesi and Giovanni Paganelli -- Sentinel Lymph Node Biopsy in Cancers of the Gastrointestinal Tract / Yuko Kitagawa, Sukamal Saha and Masaki Kitajima -- Sentinel Lymph Node Biopsy in Prostatic Cancer / Alexander Winter, Harry Vogt, Dorothea Weckermann, Rolf Harzmann and Friedhelm Wawroschek -- Radioguided Biopsy of the Sentinel Lymph Node in Patients with Non-Small Cell Lung Cancer / Giuseppe Boni, Gianpiero Manca, Franca M. A. Melfi, Marco Lucchi and Alfredo Mussi, et al. -- Sentinel Lymph Node Biopsy in Thyroid Cancer / Massimo Salvatori, Domenico Rubello, Michael J. O'Doherty, Maria Rosa Pelizzo and Giuliano Mariani -- Histopathology of Sentinel Lymph Nodes / Giuseppe Viale, Giovanni Mazzarol and Eugenio Maiorano -- Frozen Section and Imprint Cytology in Sentinel Lymph Node Biopsy for Breast Cancer / Santo V. Nicosia and Charles E. Cox -- Molecular Assessment of Sentinel Lymph Nodes / Farin Amersi, Armando E. Giuliano and Dave S.B. Hoon -- Part III. Occult Lesion Localization -- Where It All Began: The Heritage of Radioimmunoguided Surgery / Fausto Badellino, Mario Roselli, Marzio Perri, Fiorella Guadagni and Giuliano Mariani -- Radioguided Occult Lesion Localization in the Breast / Giovanni Paganelli, Concetta De Cicco, Giovanna Gatti and Alberto Luini -- Minimally Invasive Radioguided Parathyroidectomy in Primary Hyperparathyroidism / James Norman, Domenico Rubello, Armando E. Giuliano and Giuliano Mariani -- Radioguided Surgery of Neuroendocrine Tumors / Richard P. Baum, Sergio Sandrucci and Stefan Adams -- Radioguided Surgery of Solitary Pulmonary Nodules / Giuseppe Boni, Franca M. A. Melfi, Gianpiero Manca, Marco Lucchi and Alfredo Mussi, et al. -- Radioguided Surgery of Occult Lesions in Patients with Thyroid Cancer / Domenico Rubello, Massimo Salvatori, Maria Rosa Pelizzo, Giuseppe Boni and Giuliano Mariani -- Radioguided Bone Lesion Localization / Gianpiero Manca, Giuliano Mariani and Lary A. Robinson.
  • "This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It examines the relative benefits of various radiopharmaceuticals and provides guidance on dose estimation and agent selection. Utilizing figures of merit for quantitative assessment, it covers standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, vivo methods for obtaining activity data, errors of activity estimation techniques, phantom-based and patient-based dose estimates and their associated uncertainties, and options available to clinical physicists. Supported by numerous examples from clinical trials, it discusses two and three dimensional estimation processes, including modern hybrid scanners such as SPECT/CT and PET/CT"--Provided by publisher.
  • Imaging, delineation and immobilization: MRI and MR-spectroscopy -- PET imaging in prostate cancer -- Phase contrast X-ray imaging- next generation CT imaging -- Organ contouring for IMRT -- General aspects of patient immobilization -- Internal immobilization: From rectal balloon to hyaluronic acid -- Clinical endpoints: Biochemical recurrence? a valuable endpoint? -- Overall and disease-free survival ? too long to wait? -- Late toxicity ? current scoring concepts -- Quality of life: Assessment and Correlates -- Dose escalation and new radiation techniques: Dose escalation ? an update on randomized clinical trials -- IMRT for prostate cancer -- IGRT- how and when -- Tracking in prostate cancer -- Locally advanced disease: Techniques of pelvic lymphatic irradiation -- Prophylactic treatment of the pelvic lymphatics: pro -- Prophylactic treatment of the pelvic lymphatics: contra -- Hormonal therapy and radiation therapy -- randomized and prospective trials -- Treatment of clinically involved lymph nodes -- Hypofractionation: Hypofractionation in prostate cancer- biological aspects -- Hypofractionation: Clinical data -- Simultaneous integrated boost techniques -- Brachytherapy: Principals of 3D, highly conformal brachytherapy -- Seed implantation -- HDR brachytherapy -- Adjuvant treatment and salvage treatment: Target volume definition in postoperative radiotherapy -- Randomized trials for adjuvant radiotherapy -- Salvage radiotherapy after radical prostatectomy -- Salvage prostatectomy after radiotherapy -- Use of protons and heavy ions: Proton therapy for prostate cancer: technological and clinical aspects -- There is evidence for the superiority of protons or heavy ions, pro -- There is evidence for the superiority of protons or heavy ions, contra. .
  • In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy.
  • Epidemiology and databases -- Rare and uncommon gynecological cancers: a clinical guide -- The contribution of diagnostic imaging in rare gynecological malignancies -- Mucinous cancers: ovary -- Pseudomyxoma peritonei -- Ovarian clear cell carcinoma -- Clear cell carcinoma of the ovary -- The continuum of serious ovarian tumors of low malignant potential and low-grade serous carcinoma of the ovary -- Sex cord-stromal tumors -- Squamous cell carcinomas arising from dermoids -- Ovarian carcinosarcomas -- Small cell and neuroendocrine cancers of the ovary -- Primary ovarian carcinoids and neuro-endocrine tumors including struma ovarii -- Reed uterine carcinosarcomas -- Leiomyosarcomas of uterus -- Mucinous tumors of the uterine corpus -- Clear cell cancers of uterus -- Small cell and neuroendocrine cancers of the cervix -- Primary malignant melanoma of the vulva and vagina -- Gynecologic cancers in pregnancy: guidelines of an international consensus meeting.
  • Rare lymphomas 2014
    The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.
  • This book provides practitioners with a single volume that reviews the clinical and pathologic features of rarely encountered cutaneous neoplasms. The text includes an in-depth discussion of the clinical findings, as well as the histologic and immunologic features of these diseases that are rarely encountered, reported, or recognized. Additional laboratory data used to make and support the diagnoses with some therapeutic and prognostic hints are discussed for each entity. The volume is organized into general categories correlating with the cell(s) of origin. An atlas of clinical manifestations is presented for each entity that will serve as a bedside clinical reference, followed by a series of photomicrographs depicting the histologic changes. In all cases, recent updates on molecular tools helpful in attaining the diagnosis are added to the sections on histology and immunohistochemistry. Rare Malignant Skin Tumors is a valuable bedside reference for the practicing dermatopathologist, general pathologist reviewing skin biopsies, general dermatologists, cutaneous oncologists and Mohs? surgeons.
  • This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section of the book addresses general issues including epidemiology, risk factors/etiology, biology and genetics, prevention, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms, thus providing the reader with access to the developing clinical network for rare tumors in children. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, survival outcome, follow-up, and adverse effects. These chapters are organized by site according to the clinician{u2019}s approach to the patient. Each chapter includes an introduction to the differential diagnostic assessment of tumors at the site in question, encompassing both frequent and rare tumor types. This approach should enable the clinician to take rare entities into account during the diagnostic assessment, so that the initial diagnostic steps are performed optimally. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. This well-illustrated book will prove an invaluable source of information for all pediatricians and oncologists faced with the often difficult task of diagnosing and treating rare tumors in the pediatric age group.
  • "Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer's disease could be stabilized by one or both these drugs."--P. [4] of cover.
  • Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super.
  • This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
  • Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz -- Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki -- Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan -- Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend -- A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper -- Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik -- Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang -- Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.
  • Epidemiology, Screening, and Clinical Staging / Michael J. Lipsky, Christopher M. Deibert -- Molecular Biology and Genetics / Jeff Klomp, Karl Dykema, Bin Tean Teh, Kyle Furge -- Familial and Hereditary Syndromes / Brian Shuch, Peter Pinto -- Pathology of Renal Cell Carcinoma / Fang-Ming Deng, Jonathan Melamed, Ming Zhou -- Imaging of Renal Cancer / Jalil Afnan, Christoph Wald -- Molecular Imaging for Renal Cell Carcinoma / Jian Q. Yu, Yamin Dou -- History of Renal Surgery for Cancer / Kamal Nagpal, Karim Hamawy -- Natural History, Role of Biopsy, and Active Surveillance of Renal Masses / Anthony T. Corcoran, Marc C. Smaldone, Robert G. Uzzo -- Interventional Radiology and Angioinfarction: Transcatheter Embolization of Renal Tumors / Sebastian Flacke, Shams Iqbal -- Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma / Patrick A. Kenney, Christopher G. Wood -- Rationale for Partial Nephrectomy / Nicholas Donin, William Huang -- Objectifying Complexity of Kidney Cancers: Relationships of Tumor Anatomy and Outcomes / Serge Ginzburg, Alexander Kutikov, Robert G. Uzzo -- Open Partial Nephrectomy / Patrick A. Kenney, Matthew F. Wszolek, John A. Libertino -- Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses / Casey G. Kowalik, David Canes, Ali Moinzadeh -- Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava / Chad Wotkowicz, John A. Libertino -- Role of Lymphadenectomy / Prof. Dr. Hein Van Poppel -- Postoperative Surveillance Protocols for Renal Cell Carcinoma / Megan M. Merrill., Jose A. Karam -- Role of Surgery in Locally Recurrent and Metastatic Renal Cancer / Paul Russo -- Outcomes: Prognostic Factors, Models, and Algorithms / Brandon K. Isariyawongse, Michael W. Kattan -- Adjuvant Systemic Therapy, Immunotherapy, and Targeted Treatment / Linda Cerbone, Cora N. Sternberg -- Role for Radiation Therapy in Renal Cancer / Andrea McKee, Arul Mahadevan, Timothy Walsh -- Surgical Management for Transitional Cell Carcinoma of the Upper Tract / Jason R. Gee -- Management of Non-clear Cell Renal Cell Carcinoma / Henry J. Conter, Jose A. Karam, Nizar M. Tannir.
  • Part 1. Localized Disease -- Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors / Frédéric D. Birkhäuser, Nils Kroeger and Allan J. Pantuck -- Pathology of Renal Cell Carcinoma / Ming Zhou and Huiying He -- Familial Renal Cell Carcinoma / Simon P. Kim and Bradley C. Leibovich -- Imaging of Renal Cell Carcinoma / Andrei S. Purysko, Erick M. Remer and Brian R. Herts -- Prognostic Factors for Localized Renal Cell Carcinoma / Brian R. Lane -- Part 2. Management of Localized RCC -- Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass Biopsy / Matthew N. Simmons and Steven C. Campbell -- Radical Nephrectomy for Localized Renal Tumors: Optimum Oncological and Renal Functional Considerations / Paul Russo -- Nephron-Sparing Surgery for Renal Cancer / Alon Z. Weizer, Jeffery S. Montgomery and Khaled S. Hafez -- Thermal Ablation / Surena F. Matin and Kamran Ahrar -- Active Surveillance of the Small Renal Mass / Marc C. Smaldone, Daniel Canter, Alexander Kutikov and Robert G. Uzzo -- Part 3. Locally Advanced Disease -- Locally Advanced Renal Cell Carcinoma / Stephen H. Culp and Christopher G. Wood -- Neoadjuvant Targeted Therapy and Consolidative Surgery / Sean P. Stroup and Ithaar H. Derweesh -- Part 4. Advanced Disease -- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects) / Alexandra Arreola and W. Kimryn Rathmell -- Prognostic Factors in Advanced Renal Cell Carcinoma / Michael M. Vickers and Daniel Y. C. Heng -- Integration of Surgery in Metastatic Renal Cancer / Tom Powles and Axel Bex -- Immunotherapy for Renal Cell Carcinoma / Diwakar Davar, Moon Fenton and Leonard J. Appleman -- Targeted Therapy: Vascular Endothelial Growth Factor / Linda Cerbone and Cora N. Sternberg -- Mammalian Target of Rapamycin in Renal Cell Carcinoma / Eric Jonasch and Michel Choueiri -- Palliative and Supportive Care for Renal Cancer / Armida Parala-Metz and Mellar Davis.
  • Pt. 1. Biology of renal cell carcinoma -- pt. 2. Current and future molecular targets for RCC.
  • Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.
  • Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
  • This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
  • Principles of cancer treatment: impact on reproduction -- Fertility preservation options for females -- Options for fertility preservation in men and boys with cancer -- Contraception and cancer treatment in young persons -- Sexual health during cancer treatment -- Unique reproductive concerns of young women with breast cancer -- Pregnancy and cancer -- Preimplantation genetic diagnosis for hereditary cancers -- Non-traditional family building planning -- Parenting with cancer I: developmental perspective, communication, and coping -- Parenting with cancer II: parenting at different stages of illness -- Pediatric oncology and reproductive health -- Institutional approaches to implementing fertility preservation for cancer patients -- Patient provider communication and reproductive health -- Fertility preservation in cancer patients: ethical considerations -- Legal issue and of assisted reproductive technologies.
  • Introduction and generation of chimeric and humanized mAbs -- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment -- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs -- Mechanisms of antibodies-mediated responses, in vitro and in vivo -- Molecular Pathways -- Molecular Signatures -- Identification of resistance targets for intervention -- Various chemicals that can sensitize resistant tumor cells -- Other mAbs -- Proteasome inhibitors -- Divalent mAbs -- Antibodies coupled to chemical inhibitors -- Antibodies coupled to cytokines -- Nanoparticles with mAbs.
  • The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.
  • Retinoblastoma 2010
  • Clinical advances and emerging treatment strategies / Timothy G. Murray -- Laboratory discoveries in retinoblastoma / Samuel K. Houston & Timothy G. Murray -- Incidence, prevalence and epidemiology / Ricardo Garza & Dan S. Gombos -- Clinical features and diagnosis of retinoblastoma / Matthew A. Cunningham & H. Culver Boldt -- Genetics of retinoblastoma and genetic counseling / Jessica Moline & Arun D. Singh -- Anesthetic considerations for children with retinoblastoma / Jacqueline Tutiven & Michael M. Vigoda -- Radiation therapy in retinoblastoma / Shiv C. Desai, Derek M. Isrow & Arnold M. Markoe -- Chemotherapy in the management of retinoblastoma / Ziad A. Khatib & Wenliang Geng -- Retinoblastoma treatment / Samuel K. Houston & Timothy G. Murray -- Treatment of extraocular and metastatic retinoblastoma / Ira J. Dunkel & Guillermo L. Chantada -- Second malignancies and other long-term effects in retinoblastoma survivors / Annette C. Moll, Jennifer van Dijk, Machteld I. Bosscha, Charlotte J. Dommering, Pim de Graaf, W. Arjenne Kors & Flora E. van Leeuwen -- Visual rehabilitation for retinoblastoma / D/ Wilkin Parke & Aaron Gold -- Retinoblastoma in the developing world / Vikas Khetan, Sabyasachi Sengupta, Fariooz P. Manjandavida & Santosh G. Honavar -- Index.
  • Chapter 1: Overview of Retrovirology -- Chapter 2: Mechanisms of Oncogenesis by Retroviruses -- Chapter 3: Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses -- Chapter 4: Genetics of Host Resistance to Retroviruses and Cancer -- Chapter 5: Endogenous Retroviruses and Cancer -- Chapter 6: Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer -- Chapter 7: Cancers Induced by Piscine Retroviruses -- Chapter 8: The Immune Response to Oncogenic Retroviruses -- Chapter 9: Retrovirus-induced Immunodeficiency and Cancer.
  • RNA and cancer 2013
    Coupling Between Transcription and Alternative Splicing / Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt -- Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray / Marieta Gencheva ... [et al.] -- Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing / Lulzim Shkreta ... [et al.] -- Alternative Splicing of Tumor Suppressors and Oncogenes / Claudia Ghigna, Silvano Riva, Giuseppe Biamonti -- MicroRNAs in Cancer / Jianzhong Jeff Xi -- The Perinucleolar Compartment: RNA Metabolism and Cancer / John T. Norton, Sui Huang -- Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer / Christian Kroun Damgaard, Jens Lykke-Andersen -- Alternative Pre-mRNA Splicing, Cell Death, and Cancer / Kong Ruirui ... [et al.] -- Oligonucleotide Therapeutics in Cancer / Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani -- Clinical Perspective on Chemo-Resistance and the Role of RNA Processing / Nancy L. Krett, Shuo Ma, Steven T. Rosen.
  • Role of Capsaicin in Cancer Prevention -- Role of Death Receptors Belonging to the TNF Family in Capsaicin-Induced Apoptosis of Tumor Cells -- Role of Capsaicin in Prostate Cancer -- Capsaicin and the Urinary Bladder -- Inhibition of Pancreatitis and Carcinogenesis by Capsaicin -- Cytochrome P450-Dependent Modification of Capsaicinoids: Pharmacological Inactivation and Bioactivation Mechanisms -- The Cancer-Suppressing and -Promoting Actions of Capsaicin -- Oxidative Stress by Capsaicin in Cancer.
  • Interdiction of sphingolipid metabolism to improve standard cancer therapies -- Diverse functions of ceramide in cancer cell death and proliferation -- Cermaide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance -- Use of acid sphingomyelinase for cancer therapy -- Hypoxia therapeuric resistance and sphingosine 1-phosphate -- Therapeutic potential of targeting SK1 in human cancers -- Sphinogosine kinase 1 in cancer -- Natural products as platforms for the design of sphingolipid-related anticancer agents.
  • This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Ch. 1. Anatomy and physiologic morphology -- Ch. 2. Abnormalities of mammary growth and development -- Ch. 3. Inflammatory and reactive tumors -- Ch. 4. Specific infections -- Ch. 5. Papilloma and related benign tumors -- Ch. 6. Myoepithelial neoplasms -- Ch. 7. Adenosis and microglandular adenosis -- Ch. 8. Fibroepithelial neoplasms -- Ch. 9. Ductal hyperplasia: ordinary and atypical -- Ch. 10. Precancerous breast disease: epidemiologic, pathologic, and clinical considerations -- Ch. 11. In Situ (intraepithelial) carcinoma: an overview -- Ch. 12. Staging of breast carcinoma -- Ch. 13. Intraductal carcinoma -- Ch. 14. Invasive duct carcinoma: assessment of prognosis, morphologic prognostic markers, and tumor growth rate -- Ch. 15. Tubular carcinoma -- Ch. 16. Papillary carcinoma -- Ch. 17. Medullary carcinoma -- Ch. 18. Carcinoma with metaplasia -- Ch. 19. Squamous carcinoma -- Ch. 20. Mucinous carcinoma -- Ch. 21. Apocrine carcinoma -- Ch. 22. Mammary carcinoma with endocrine features -- Ch. 23. Small cell (oat cell) carcinoma -- Ch. 24. Secretory carcinoma -- Ch. 25. Mammary carcinoma with osteoclast-like. giant cells -- Ch. 26. Cystic hypersecretory carcinoma and cystic hypersecretory hyperplasia -- Ch. 27. Adenoid cystic carcinoma -- Ch. 28. Cribriform carcinoma -- Ch. 29. Lipid-rich carcinoma -- Ch. 30. Gylcogen-rich carcinoma -- Ch. 31. Invasive micropapillary carcinoma -- Ch. 32. Paget's disease of the nipple -- Ch. 33. Lobular carcinoma In Situ and atypical lobular hyperplasia -- Ch. 34. Invasive lobular carcinoma -- Ch. 35. Unusual clinical presentations of carcinoma -- Ch. 36. Metastases in the breast from nonmammary malignant neoplasms -- Ch. 37. Benign proliferative lesions of the male breast -- Ch. 38. Carcinoma of the male breast -- Ch. 39. Breast tumors in children -- Ch. 40. Benign mesenchymal neoplasms -- Ch. 41. Sarcoma -- Ch. 42. Lymphoid and hematopoietic tumors -- Ch. 43. Pathologic effects of therapy -- Ch. 44. Cutaneous neoplasms -- Ch. 45. The pathology of axillary and intramammary lymph nodes -- Ch. 46. Pathologic examination of breast and lymph node specimens.
  • Anatomy and physiologic morphology -- Abnormalities of mammary development and growth -- Inflammatory and reactive tumors -- Specific infections -- Papilloma and related benign lesions -- Myoepithelial neoplasms -- Adenosis and microglandular adenosis -- Fibroepithelial neoplasms -- Ductal hyperplasia: usual and atypical -- Precarcinomatous breast disease: epidemiologic, pathologic, and clinical considerations -- Ductal carcinoma In Situ -- Invasive ductal carcinoma: assessment of prognosis with morphologic and biologic markers -- Tubular carcinoma -- Papillary carcinoma -- Medullary carcinoma -- Carcinoma with metaplasia and low-grade adenosquamous carcinoma -- Squamous carcinoma -- Mucinous carcinoma -- Apocrine carcinoma -- Mammary carcinomas with endocrine features -- Small cell carcinoma -- Secretory carcinoma -- Mammary carcinoma with osteoclast-like giant cells -- Cystic hypersecretory carcinoma and cystic hypersecretory hyperplasia -- Adenoid cystic carcinoma -- Invasive cribriform carcinoma -- Lipid-rich carcinoma -- Glycogen-rich carcinoma -- Invasive micropapillary carcinoma -- Paget disease of the nipple -- Lobular carcinoma In Situ and atypical lobular hyperplasia -- Invasive lobular carcinoma -- Unusual clinical presentation of carcinoma -- Metastases in the breast from nonmammary neoplasms -- Benign proliferative lesions of the male breast -- Carcinoma of the male breast -- Breast tumors in children -- Benign mesenchymal neoplasms -- Sarcoma -- Lymphoid and hematopoietic neoplasms of the breast -- Pathologic effects of therapy -- Cutaneous neoplasms -- The pathology of axillary and intramammary lymph nodes -- Pathologic examination of breast and lymph node specimens, including sentinel lymph nodes -- Molecular classification and testing of breast carcinoma.
  • "Edward Laws and Jason Sheehan have edited the first comprehensive guide to the management of the large varieties of pathologies that arise in the sellar and parasellar area. Over the past two decades change in management practices have been underpinned by a better understanding of the nature of the pathology, improved imaging and a refinement of both surgical and radiation therapy techniques. The location of the sellar and parasellar region has challenged neurosurgeons (and radiotherapists) to develop innovative refined approaches to the region, often using the best of skull base, endoscopic and microsurgical techniques. These have been utilized within the context of an improved understanding of the pathology, with the imperative that the treatment (or therapy) must optimize control of the pathology, whilst minimizing morbidity"--Provided by publisher.
  • Sexual dysfunction presents a major challenge to physicians who take on the task of treating men with prostate cancer. While curing the disease and saving a life is paramount, improving technologies and therapies offer skilled surgeons and clinical oncologists the opportunity to eradicate the disease without compromising sexual function. In Sexual Function of the Prostate Cancer Patient, John Mulhall and a panel of internationally recognized experts on prostate cancer and sexual function assess in detail the current state of prostate cancer treatment. The authors offer a broad overview of the pathophysiology and treatment of erectile dysfunction in men with prostate cancer, reviewing the latest findings regarding erection-sparing radiation therapy and sexual function outcomes after laparascopic and robotic prostatectomy. Additional chapters discuss intra-operative maneuvers to minimize post-operative erectile dysfunction and pharmacologic penile preservation and rehabilitation. Timely and authoritative, Sexual Function in the Prostate Cancer Patient is a highly readable guide to preserving post-prostate cancer sexual function that no urologist or radiation and medical oncologist should be without.
  • Novalis® Shaped Beam Radiosurgery has set new standards by delivering highly precise radiation treatments to tumors anywhere in the body through the use of a proprietary multileaf collimator. By shaping the radiation beam to the exact contours of the tumor or lesion, Novalis permits maximum dose delivery to the entire tumor while protecting healthy tissue; this makes it eminently suitable for the treatment of irregularly shaped tumors. Novalis features 360° gantry rotation, stereoscopic kV X-ray imaging, and 6D robotic patient positioning. Dose delivery is typically achieved through fixed conformal beams, dynamic conformal arcs, and IMRT, and most brain treatments do not require an invasive head frame. This book provides a complete guide to radiosurgery treatments with Novalis. After a thorough discussion of the clinical and technical basis for Shaped Beam Radiosurgery, current clinical applications are considered in detail, including brain, body, skull base, and spinal tumors as well as arteriovenous malformations. Careful consideration is also given to future developments and applications, including new technologies that promise to offer even more accurate treatments. This state-of-the-art book will appeal to a wide audience of physicians and their multidisciplinary clinical and technical collaborators.
  • "The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blockade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study."--Back cover
  • This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
  • This text describes research suggesting that abnormal activation of signaling pathways is a critical event in cancer pathogenesis, and describes the emerging ability to design small molecules, protein therapeutics, and other forms of targeted cancer therapies.
  • Biopsy techniques and interpretation / Deborah F. MacFarlane and Ronald P. Rapini -- Topical therapies for nonmelanoma skin cancers / Abel Torres and Tejas Desai -- Chemical peels for precancerous skin lesions / Gary D. Monheit and Chad L. Prather -- Photodynamic therapy / Nathalie C. Zeitouni, Allan Oseroff, and David J. Najarian -- Intralesional and perilesional treatment of skin cancers / Christopher J. Arpey, Nicole M. Annest, Stephen B. Tucker, Ronald P. Rapini, and Deborah F. MacFarlane -- Electrodesiccation and curettage / Gloria F. Graham -- Cryosurgery / Gloria F. Graham -- Optimizing surgical outcomes / Thomas Stasko and Amy Ross -- Anesthesia / Susannah L. Collier and George J. Hruza -- Excision techniques, staples, and sutures / Mollie A. MacCormack -- Mohs surgery / Desiree Ratner and Jennifer L. MacGregor -- Cutaneous flaps / Tatyana Humphreys -- Techniques in skin grafting / Deborah F. MacFarlane -- Nail surgery and malignant tumors of the nail unit / Deborah F. MacFarlane and Richard K. Scher -- Practical management of melanoma / Mark F. Naylor -- Skin cancer in skin of color / Brooke A. Jackson -- Management of skin cancers in solid organ transplant recipients / John Carucci and Dariush Moussai -- Imaging of head and neck skin cancer / Komal Shah, Jane Onufer, and Deborah F. MacFarlane -- Radiation oncology in skin cancer treatment / Susan L. McGovern and Matthew T. Ballo -- When to refer out / Daniel M. Siegel, Laura T. Cepeda, and Deborah F. MacFarlane -- Chemoprevention of skin cancer / Fiona Zwald and David Lambert.
  • Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, dermatologists, general surgeons, and veterinary oncologists.
  • The dramatic increase in the incidence of skin cancers is a major concern worldwide and relates not only to melanoma but also to other cancers, including Merkel cell and basal cell carcinomas. Recently, the WHO has summarized the genetic and pathologic features of skin cancers in its book series. However, the WHO's proposed classification of certain disease entities, such as basal cell carcinomas, is still novel for many dermatologists. This book covers the entire spectrum of cutaneous malignancies in accordance with the new WHO classification. Epidemiology, pathogenesis, diagnosis, and therapy are all reviewed in detail, and care is taken to link the diagnostic and genetic features to optimized therapeutic strategies.-- Provided by publisher.
  • Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
  • Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • Presents authorataive coverage of state-of-the-art techniques for diagnosing and managing tumors of the spine and spinal cord. Covers fundamentals of spinal cord anatomy and the pathology of spinal tumors to evaluation, diagnosis, and treatment techniques for specific spinal tumors.
  • Radiobiology of radiosurgery / Jae Ho Kim and Stephen Brown -- Clinical spinal cord tolerance to radiosurgery / Simon S. Lo [and 10 others] -- Management of spinal cord toxicity / Samuel Ryu, Steve Brown, and Jae Ho Kim -- Histopathologic examination of spinal lesions after radiosurgery / Nathan T. Zwagerman [and 6 others] -- Stereotactic spine radiotherapy : image guidance and patient immobilization / Max Dahele and Ben Slotman -- Treatment planning for spine radiosurgery / David Schlesinger, K. Martin Richardson, Kelly M. Spencer, Brian Winey, and Jason Sheehan -- Quality assurance and treatment delivery / Fang-fang Yin, Zheng Chang, and Justus Adamson -- Contemporary devices for spinal radiosurgery / Christoph Fürweger [and 5 others] -- Imaging, target delineation, and dose prescription / Eric Chang, Omar Ragab, Sukhjeet Batth, Shelly Bian, and Lydia Nng -- Radiosurgery for the re-treatment of progressive spine metastases / Andrew A. Kanner and Benjamin W. Corn -- Clinical outcomes after spinal radiosurgery / Peter C. Gerszten and John C. Flickinger -- Clinical outcomes of pain and quality of life after spinal radiosurgery / Lily Angelov, Sam Chao, and John Suh -- Radiosurgery for spinal canal compromise and spinal cord compression / Richard A. Rammo, Ian Y. Lee, Jack P. Rock, and Samuel Ryu -- Postoperative radiosurgery and minimally invasive surgical techniques / Tobias A. Mattei [and 7 others] -- Radiosurgery and percutaneous cement augmentation / Michael Decuypere and Jason A. Weaver -- Treatment failure, complications, and their management / Nicolaus Andratschke and Matthias Guckenberger -- Patient evaluation and treatment selection for spinal canal compromise / Samuel Ryu and Mark Bilsky -- Radiosurgery for benign extramedullary tumors of the spine / Iris C. Gibbs, Navjot Chaudhary, Steven D. Chang, Robert L. Dodd, and John R. Adler, Jr -- Radiosurgical treatment of spinal chordomas / James P. Caruso, Mark H. Bilsky, Josh Yamada, and Ilya Laufer -- The role of radiosurgery in the treatment of primary malignant spine and spinal cord tumors / Moon-Jun Sohn, Dong-Joon Lee, and Hye-Ran Lee -- Radiosurgery for spinal cord arteriovenous malformations / Maziyar A. Kalani, Iris C. Gibbs, John R. Adler, Jr., and Steven D. Chang -- Multidisciplinary approach for the evaluation and treatment of metastatic spinal tumors / Ganesh M. Shankar, Kevin Oh, Kristina Shultz, and John H. Shin.
  • Georg Stuebinger verifies each of the 24 most common and deadliest cancer diseases worldwide including well-established and potential risk factors resp. important symptoms by using current literature and comprehensive scientific studies with a direct relation to the impact of various parameters of sports and exercise training such as training type, intensity, volume, duration and frequency complete with the corresponding effects. The impact of sports and exercise training as a potential therapy on reduced risk of cancer has been widely discussed in many scientific articles over the last few years, but is still widely unknown. In 2012, about 14 m cancer cases and 8.2 m cancer deaths appeared worldwide whereby cancer represents one of the most frequent causes of death accounting for approximately 13% with a continuously rising number.
  • General Issues. Historical Overview of Familial Gastric Cancer / Giovanni Corso -- Frequency of Familial Gastric Cancer / Giovanni Corso, Daniele Marrelli -- The Family Cancer Database / Giovanni Corso, Daniele Marrelli, Franco Roviello -- Genetics and Epigenetics. The E-Cadherin Gene, Structure and Function / Francesco Graziano -- E-Cadherin Germline Mutations / Joana Carvalho, Hugo Pinheiro, Carla Oliveira -- Molecular Mechanisms of Hereditary Diffuse Gastric Cancer Initiation and Progression / Parry Guilford, Bostjan Humar -- Germline Missense Mutants in Hereditary Diffuse Gastric Cancer / Joana Figueiredo, Raquel Seruca -- Alternative Mechanisms to Germline CDH1 Mutations in Hereditary Diffuse Gastric Cancer / Hugo Pinheiro, Joana Carvalho, Carla Oliveira -- Beyond CDH1 Mutations: Causes of Hereditary Diffuse Gastric Cancer / Samantha Hansford B.Sc., David Huntsman, FRCPC -- Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors / Marina Leite, Giovanni Corso, Sónia Sousa, Joana Carvalho -- Pathology. Hereditary Diffuse Gastric Cancer and Lobular Breast Carcinoma / Gisela Keller -- Pathology of Hereditary Gastric Cancer / Fátima Carneiro -- Management. Clinical Criteria for Familial Gastric Cancer Definition / Giulia De Falco, Alessandro Davide Videtta -- Prophylactic Total Gastrectomy in CDH1 Germline Mutation Carriers / Francesco Ferrara, Giovanni Corso, Franco Roviello -- Gastric Cancer in Other Inherited Syndromes / Giovanni Corso, Sérgia Velho -- Clinical Management of Familial Gastric Cancer / Giovanni Corso, Daniele Marrelli, Franco Roviello -- Appendix / Giovanni Corso
  • Part 1. Bone marrow-derived stem cells -- Part 2. Embryonic stem cells -- Part 3. Cancer stem cells.
  • "This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control"--Publisher's description.
  • The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.
  • Introduction / Simon S. Lo, Bin S. Teh, Jiade J. Lu and Tracey E. Schefter -- Historical Development of Stereotactic Ablative Radiotherapy / Timothy D. Solberg, Robert L. Siddon and Brian Kavanagh -- CyberKnife System / Jun Yang, John P. Lamond, Jing Feng, Xiaodong Wu and Rachelle Lanciano, et al. -- Novalis and Varian Systems / Isaac I. Rosen and Ramiro Pino -- Helical TomoTherapy System / Whitney Warren, Walter H. Grant III and Bin S. Teh -- Elekta System / Julian R. Perks, Megan E. Daly, David Schlesinger and Stanley H. Benedict -- Treatment Planning for Stereotactic Body Radiation Therapy / Moyed Miften, Shiva K. Das, Indrin J. Chetty and David Westerly -- Launching a Stereotactic Body Radiation Therapy Program / Michael Lamba -- Radiobiology of Stereotactic Body Radiation Therapy/Stereotactic Ablative Radiotherapy / Michael D. Story, Chaitanya Nirodi and Clinton Park -- Primary Lung Cancer / Joe Y. Chang, Shervin M. Shirvani, Billy W. Loo Jr., John P. Lamond and Ben J. Slotman, et al. -- Primary Liver Cancer / Higinia R. Cárdenes and Foster Lasley -- Prostate Cancer / Hiromichi Ishiyama, Alan Katz, Angel I. Blanco, Jose Hinojosa and Simon S. Lo, et al. -- Renal Cell Carcinoma / Bin S. Teh, Hiromichi Ishiyama, Angel I. Blanco, Lee E. Ponsky and Simon S. Lo, et al. -- Gynecologic Cancer / Charles A. Kunos, Jeffrey Fabien, Yuxia Zhang, James Brindle and Nina A. Mayr -- Pancreatic Cancer / A. Yuriko Minn, Daniel T. Chang and Albert C. Koong -- Benign and Malignant Primary Spinal Tumors / Brett Cox, Iris C. Gibbs and Yoshiya Yamada -- Non-Skull Base Head and Neck Cancer / Farzan Siddiqui, David Raben, Sue S. Yom, Jiade J. Lu and Min Yao -- Skull Base Head and Neck Cancer / Sue S. Yom, David Raben, Farzan Siddiqui, Jiade J. Lu and Min Yao -- Lung Metastasis / Neha Amin, Tracey E. Schefter, Paul Okunieff, Brian Kavanagh and Michael T. Milano -- Liver Metastasis / Michelle Stinauer, Rachelle Lanciano, Tracey E. Schefter, Brian Kavanagh and Julie A. Carlson, et al. -- Adrenal Metastasis / Mirna Abboud, Simon S. Lo, Arnold C. Paulino, Daniel E. Lehane and Bin S. Teh -- Histology-Specific Metastasis / Michael T. Milano and Joseph K. Salama -- Bone Metastasis / Mirna Abboud, Arnold C. Paulino, B. S. Teh, Simon S. Lo and Rex Marco -- Spinal Metastasis / Simon S. Lo, Andrew E. Sloan, Mitchell Machtay, Bin S. Teh and Arjun Sahgal, et al. -- Reported Toxicities Associated with Stereotactic Body Radiation Therapy / Simon S. Lo, Arjun Sahgal, Charles A. Kunos, Bin S. Teh and Min Yao, et al. -- Normal Tissue Constraints / Simon S. Lo, Arjun Sahgal, Lijun Ma, Ben J. Slotman and Zhibin Huang, et al. -- Erratum: Primary Liver Cancer / Higinia R. Cárdenes and Foster Lasley -- Erratum: Bone Metastasis / Mirna Abboud, Arnold C. Paulino, B. S. Teh, Simon S. Lo and Rex Marco.
  • Stereotactic body radiation therapy : lung cancer / Simon S. Lo, Bin S. Teh, Nina A. Mayr & Mitchell Machtay -- Stereotactic body radiation therapy and lung cancer / Gregory M.M. Videtic -- Radiobiology of stereotactic body radiation therapy / Zhibin Huang, Nina A. Mayr, Simon S. Lo & William Yuh -- SBRT : frame-based and image-guided strategies / Meredith Elana Giuliani & Andrea Bezjak -- CyberKnife®-based SBRT for lung cancer / Martina Descovich, Danita Kannarunimit & Sue S. Yom -- SBRT : evolving standards in tumor response evaluation / W. Alexander Wilson & Ronald C. McGarry -- Radiation pneumonitis prediction and management / Robert Bryan Barriger -- Chest wall toxicities : prediction and management / Robert Bryan Barriger -- Surgery versus SBRT for early-stage lung cancer : a new treatment option? / W. Alexander Wilson & Ronald C. McGarry -- Target contouring & treatment planning in lung SBRT / Meredith Elana Giuliani & Jean-Pierre Bissonnette -- Ask the experts : strategies to minimize complications from SBRT for lung cancer / Simon S. Lo, Bin S. Teh, Nina A. Mayr & Mitchell Machtay -- Multiple choice questions : answers.
  • This practical guide covers the basic aspects of stereotactic radiotherapy systems and treatment. As an emerging field, stereotactic body radiotherapy (SBRT) offers image-guided radiation that is directed at extremely well-defined tumor targets within the body, delivering very high doses of radiation. Indications for SBRT have expanded extensively in recent years from intracranial treatment to extracranial, leading to the development of a thriving subspecialty within radiation oncology. The expertise on these methods is concentrated across a few centres, mainly in the USA. However, as the technique is increasingly being adopted worldwide, specialists require further training in using it. Stereotactic Body Radiotherapy ? A Practical Guide provides a valuable aid for this purpose and is of particular interest to clinical oncologists and their trainees.
  • Targeting oncogenic drivers / Zhao, Y.; Adjei, A.A. (Buffalo, N.Y.) -- Successes and limitations of targeted cancer therapy in breast cancer / Curigliano, G.; Criscitiello, C. (Milan) -- Successes and limitations of targeted cancer therapy in colon cancer / Khne, C.-H. (Oldenburg) -- Successes and limitations of targeted cancer therapy in gastrointestinal stromal tumors / Casali, P.G. (Milano) -- Successes and limitations of targeted cancer therapy in lung cancer / Suda, K. (Osaka-Sayama/Fukuoka); Mitsudomi, T. (Osaka-Sayama) -- Successes and limitations of targeted cancer therapy in melanoma / Romano, R.; Michielin, O. (Lausanne) -- / successes and limitations of targeted cancer therapy in ovarian cancer / Damia, G. (Milan); Sessa, C. (Bellinzona) -- Successes and limitations of targeted therapies in renal cell carcinoma / Pracht, M.; Berthold, D. (Lausanne).
  • 1. Febrile neutropenia -- 2. Transfusion support -- 3. Tumor lysis syndrome -- 4. Cardiopulmonary emergencies -- 5. Neurologic emergencies -- 6. Hyperleukocytosis -- 7. The acute abdomen -- 8. Thrombotic disorders -- 9. Pain management -- 10. Nausea and vomiting -- 11. Oral mouth care and mucositis -- 12. Nutrition -- 13. Management of acute radiation side effects -- 14. Prevention of infection -- 15. Hematopoietic growth factors -- 16. Immunization practice in pediatric oncology -- 17. Central venous catheters: care and complications -- 18. Knowledge gaps and opportunities for research.
  • Supportive oncology 2011
    2011 ClinicalKey
  • This book provides an educational resource of modern and advanced operative techniques for patients with GI cancers. The textbook is designed to provide a step-by-step surgical approach, highlighting key learning points and potential operative pitfalls. When appropriate, two or more different approaches on an operative procedure are presented to provide additional perspective on surgical techniques. Written descriptions of laparoscopic and robotic cancer operations are paired with online video presentations of the same cancer operation. Written by experts in the field, Surgery for Cancers of the Gastrointestinal Tract: A Step-by-Step Approach provides a concise summary of the current management of each GI cancer and is of great utility to not only surgeons at all levels of training, but also for surgeons in practice who seek to reinforce or learn new surgical techniques.
  • Although there has been a slow but steady decrease in incidence, gastric cancer remains the second leading cause of cancer death worldwide. Several aspects of the oncological and surgical management are still controversial and so gastric cancer represents a challenge for the surgeon. This book aims to delineate the state of the art in the surgical and oncological treatment of gastric cancer, describing the new TNM staging system, the extent of visceral resection and lymphadenectomy focusing on the different open and minimally invasive surgical techniques and discussing intraoperative chemohyperthermia and neoadjuvant and adjuvant treatment. Operative endoscopy and endoscopic ultrasonography are also discussed, as these now have an important role in both diagnostic work-up and palliative care of gastric cancer patients. Only a multidisciplinary approach involving the surgeon, gastroenterologist, and oncologist can produce the comprehensive and integrated overview that today constitutes a winning strategy for the optimization of results.What we hope we have achieved is a flexible, up-to-date, exhaustive publication, rich in illustrations and consistent with evidence-based medicine.
  • History of cerebellopontine angle surgery -- Microsurgical anatomy of the cerebellopontine angle by the retrosigmoid approach -- Neuropathology of the cerebellopontine angle and its surroundings -- Approaches to the cerebellopontine angle -- Vestibular schwannomas -- Neurofibromatosis Type 2 and other bilateral cerebellopontine angle tumors -- Meningiomas -- Cerebellopontine angle epidermoids -- Nonvestibular schwannomas -- Jugular foramen tumors -- Other cerebellopontine angle tumors -- Management of facial palsy.
  • History -- Anatomy -- Intramedullary tumors -- Extramedullary tumors -- Epidural tumors.
  • Historical Background or De quibusdam Renum glandulis: The History of Adrenals / Donatella Lippi -- Surgical Anatomy / Celestino Pio Lombardi, Carmela De Crea, Francesco Pennestri and Marco Raffaelli -- Pathology / Gabriella Nesi and Raffaella Santi -- Diagnosis and Clinical Pictures / Gabriele Parenti and Massimo Mannelli -- Imaging / Massimo Falchini and Vittoria Rufini -- Perioperative Management / Tommaso Borracci, Luca Vitali, Lorenzo Antonuzzo, Liliana Sollazzi and Valter Perilli, et al. -- General Principles of Adrenal Surgery / Robin M. Cisco and Quan-Yang Duh -- Instrumentation and High-Technology / Francesco Corcione, Valentina Brancato and Michele Giuseppe Iovino -- Right Flank Trans-Abdominal Laparoscopic Adrenalectomy / Carlo Bergamini and Andrea Valeri -- Left Flank Trans-Abdominal Laparoscopic Adrenalectomy / Celestino Pio Lombardi, Marco Raffaelli, Carmela De Crea, Francesco Pennestri and Rocco Bellantone -- Posterior Retroperitoneoscopic Adrenalectomy / Rocco Bellantone, Marco Raffaelli, Carmela De Crea, Luigi Oragano and Celestino Pio Lombardi -- Open Adrenalectomy / Giorgio De Toma, Andrea Polistena and Giuseppe Cavallaro -- Other Techniques of Video-Assisted and Open Adrenalectomies / Rocco Bellantone, Francesco Corcione, Celestino Pio Lombardi, Marco Raffaelli and Carmela De Crea, et al. -- Outcome of Adrenal Surgery / Andrea Valeri and Carlo Bergamini.
  • Presents coverage that encompasses anatomy and physiology, and evaluation of breast discussions of breast cancer risk and management of breast cancer... equipping you to confidently face any challenge. Addresses hot topics including gynecomastia, neoadjuvant therapy, management of ductal carcinoma in situ, Paget's disease, risk assessment and genetic testing, breast MRI, partial breast irradiation, microarray analysis, and targeted therapies...providing you with a current perspective of this fact changing field. Begins each chapter with a bulleted list of key points, and presents crucial facts in boxes, to help facilitate review. Features abundant illustrations, photographs, and tables that clarify complex concepts. Follows a concise, logical, and consistent organization that makes the material easy to review. Whether studying for the boards or reviewing key material in preparation for a procedure.
  • This volume provides a comprehensive perspective on surgical oncologic diseases that are relevant to those who have an interest in surgical oncology. Its purpose is to distill a voluminous amount of information to readers so they will have the opportunity to apply relevant information and knowledge to their particular needs. Each chapter is written by experts in their field who provide concise and in-depth information on their topic and supply references to key articles. Illustrations, diagrams, and photographs are included to assist the visual learners. Each chapter begins with bulleted key points to focus the readers on the material that will be covered and concludes with an appendix that summarizes the salient points. This unique set-up can be used as a tool to quickly review the topic at hand. The text also includes a set of short questions and answers at the end of each chapter to reinforce the salient points. Surgical Oncology: A Practical and Comprehensive Approach is a valuable resource for Medical students, surgical oncology fellows, general surgeons, and educators.
  • Imaging of endocrine and neuroendocrine tumors -- Fine needle aspiration cytology of endocrine tumors -- Fine needle aspiration cytology of neuroendocrine tumors arising in non-endocrine organs -- Tumors of the pituitary gland -- Tumors of thyroid gland : non-C cell tumors -- Tumors of the thyroid gland (C-cells) -- Tumors of parathyroid gland -- Tumors of the adrenal cortex -- Tumors of the adrenal medulla and extra-adrenal paraganglia -- Endocrine tumors of the lung and upper airways -- Neuroendocrine tumors of the pancreas -- Neuroendocrine tumors of the gastrointestinal tract -- Neuroendocrine tumours of the breast -- Neuroendocrine tumors of female genital tract -- Neuroendocrine tumors of prostate, urinary bladder, and kidney -- Neuroendocrine tumors of other miscellaneous sites : thymus and skin -- Endocrine tumors and tumor-like lesions of infancy, childhood, and adolescents and inherited tumor syndromes -- Application of molecular diagnosis techniques in the diagnosis and management of endocrine tumors.
  • Pseudotumors -- Benign Vascular Tumors -- Benign Mesenchymal Tumors and Miscellaneous Tumors -- Benign Hepatocellular Tumors -- Benign Biliary Tumors -- Hepatocellular Carcinoma Precursor Lesions -- Hepatocellular Carcinoma -- Fibrolamellar Carcinoma -- Cholangiocarcinoma Precancerous Lesions -- Cholangiocarcinoma -- Malignant Mesenchymal Tumors -- Hematolymphoid Lesions -- Benign Pediatric Hepatic Tumors -- Malignant Pediatric Liver Tumors -- Metastatic Tumors. .
  • This volume provides a comprehensive review and detailed description of surgical techniques for prostate cancer surgery. All aspects are covered, including surgical anatomy and methods of transrectal ultrasound guided prostate biopsies, step-by-step approach techniques for radical prostatectomy, and the latest data on outcomes. Furthermore, limitations as well as tips and tricks are detailed in addition to management of common complications. Lastly, with the increasing use of ablative therapy and brachytherapy, the mechanism of action as well as the keys to obtaining optimal outcomes are illustrated. Surgical Techniques for Prostate Cancer is a concise and valuable resource to surgeons that documents the different approaches to prostate cancer surgery.
  • Epidemiology and Natural History -- Diagnosis and Staging -- Evolution of Resectability Criteria -- Surgical Strategy -- Results of Surgery and Prognostic Factors -- Preoperation Chemotherapy -- Synchronous Colorectal Liver Metastases -- Therapeutic Strategies in Unresectable Colorectal Liver Metastases -- Extrahepatic Disease -- Adjuvant Chemotherapy and Follow-Up -- LiverMetSurvey Registry: the Italian Experience.
  • Overview / Cindy L. Schwartz ... [et al.] -- Algorithms of late effects by disease / Cindy L. Schwartz, Wendy L. Hobbie, Louis S. constine -- Facilitating assessment of late effects by organ system / Cindy L. Schwartz, Wendy L. Hobbie, Louis S. Constine -- Central nervous system effects / Nina S. Kadan-Lottick, Joseph P. Neglia -- Neuroendocrine complications of cancer therapy / Wing Leung, Susan R. Rose, Thomas E. Merchant -- Ocular complications due to cancer treatment / Michael Ober, Camille A. Servodidio, David Abramson -- Head and neck / Arnold C. Paulino, Mary Koshy, Della Howell -- Adverse effects of cancer treatment on hearing / Wendy Landier, Thomas E. Merchant -- The thyroid gland / Tithi Biswas, Louis S. constine, Cindy L. Schwartz -- Cardiovascular effects of cancer therapy / M. Jacob Adams ... [et al.] -- Pulmonary effects of antineoplastic therapy / Andrea S. Hinkle, Cindy Proukou, Yuhchyau Chen -- Late gastrointestinal and hepatic effects / M.M. Hudson -- The ovary / Debra L. Friedman -- The testes / Jill P. Ginsberg, Amit Maity -- Genitourinary / Lawrence Marks, Nicole Larrier -- Musculoskeletal, integument, breast / Robert B. Marcus, Jr. ... [et al.] -- Hematopoietic stem cell transplantation / Nancy Bunin, constance DiDomenico, Virginia Guzikowski -- Second malignancies following treatment for childhood cancer / Barbara Anne Hieb, Susan K. Ogle, Anna T. Meadows -- Psychological aspects of long-term survivorship / Mary T. Rourke, Anne E. Kazak -- Legal issues / Barbara Hoffman -- Methodological issues in the study of survivors of childhood cancer / Ann C. Mertens, Yutaka Yasui -- Transition issues / Kevin C. Oeffinger, Debra A. Eshelman.
  • Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned on or off and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
  • Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • T-cell lymphomas 2013
    The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
  • Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
  • v. 2 Springer Protocols
    v. 1. Emerging strategies for targets and biomarker discovery -- v. 2. Emerging molecular targets and treatment options.
  • The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.
  • This handbook is designed to enable radiation oncologists to appropriately and confidently delineate tumor volumes/fields for conformal radiation therapy, including intensity-modulated radiation therapy (IMRT), in patients with commonly encountered cancers.The orientation of this handbook is entirely practical, in that the focus is on the illustration of clinical target volume (CTV) delineation for each major malignancy. Each chapter provides guidelines and concise knowledge on CTV selection for a particular disease, explains how the anatomy of lymphatic drainage shapes the selection of the target volume, and presents detailed illustrations of volumes, slice by slice, on planning CT images. While the emphasis is on target volume delineation for three-dimensional conformal therapy and IMRT, information is also provided on conventional radiation therapy field setup and planning for certain malignancies for which IMRT is not currently suitable.
  • Perspectives : bench to bedside and back / Jennifer Wheler and Razelle Kurzrock -- Targeted therapy in acute myelogenous leukemia / Elihu Estey -- Targeted therapy in breast cancer / Barbara S. Craft and Stacy Moulder -- Targeted therapy in chronic lymphocytic leukemia / Apostolia-Maria Tsimberidou and Michael J. Keating -- Targeted therapy in chronic myeloid leukemia / Elias Jabbour, Jorge Cortes, and Hagop Kantarjian -- Targeted therapy in colorectal cancer / Scott Kopetz -- Targeted therapy in non-small cell lung cancer / David J. Stewart -- Targeted therapy in lymphoma / Amanda Wedgwood and Anas Younes -- Targeted therapy in melanoma / Michael Davies, Sunil Patel, and Kevin B. Kim -- Targeted therapy in multiple myeloma / Yuhong Zhou, Raymond Alexanian, and Micael Wang -- Targeted therapy in myelodysplastic syndrome / Alfonso Quintás-Cardama ... [et al.] -- Targeted therapy in epithelial ovarian cancer / Maurie Markman -- Targeted drug therapy in pancreatic cancer / Don L. Gibbons, Robert A. Wolff, and Gauri Varadhachary -- Targeted therapy in prostate cancer / Amado J. Zurita, John F. Ward, and Jeri Kim -- Targeted therapy in renal cell carcinoma / Eric Jonasch and Nizar Tannir -- Targeted therapy of Sarcoma / Joseph Ludwig and Jonathan C. Trent -- Targeted and functional imaging / Vikas Kundra, Dawid Schellingerhout, and Edward F. Jackson -- Combining targeted therapies / David Hong and Lakshmi Chintala -- Drug development in cancer medicine : challenges for targeted approaches / Luis H. Camacho -- Toward personalized therapy for cancer / Sarah J. Welsh and Garth Powis.
  • Introduction: the rationale for the development of targeted drugs in cancer therapy -- Identifying critical signaling molecules for the treatment of cancer -- Tyrosine kinase inhibitors and cancer therapy -- Targeting ERBB receptors in cancer -- Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal anitbodies as alternative approaches -- Inhibition of the TGF-B signaling pathway in tumor cells -- The mammalian target of rapamycin kinase and tumor growth inhibtition -- The ras signalling pathway as a target in cancer therapy -- The mitogen-activated protein kinase pathway for molecular-targeted cancer treatment -- Clinical relevance of tareted interference with Src-mediated signal transduction events.
  • Targeted intraoperative radiotherapy is a major advance in the management of cancer patients and has been attracting massive interest worldwide following publication of the results of an important randomized controlled trial in The Lancet. This textbook is designed to introduce this innovative technology in a comprehensive manner to clinicians dealing with cancer patients. Throughout, the emphasis is on practical aspects, and the text is supported by many excellent illustrations. The editors of the book have extensive experience in targeted intraoperative radiotherapy and include co-directors of the TARGIT Academy, which runs international training courses on the technology in the United Kingdom and Germany. They have brought together multidisciplinary contributors from different centers across the world who have wide experience in the field and whose work has been recognized internationally. It is the editors' hope that this book will succeed in ensuring that targeted intraoperative radiotherapy is used effectively worldwide.
  • Targeted therapies for hepatocellular carcinoma / Luigi Bolondi -- Overview of HCC pathophysiology and drug targets / Liliana Montella & Raffaele Addeo -- Antiangiogenic strategies for the treatment of hepatocellular carcinoma / Chiun Hsu, Ying-Chun Shen & Ann-Lii Cheng -- EGF receptor inhibitors for hepatocellular carcinoma / George Papatsimbas, Christina Chatedaki & Dimitris Zacharoulis -- mTOR inhibitors / Gerhard Treiber & Thomas Wex -- Histone deacetylase inhibitors (epigenetic alterations) / Sergio Valente & Antonello Mai -- Hepatocellular carcinoma therapy : combination is the future / Jean-François Dufour -- Other new targeted therapies / Jairo A. Garcia & Lewis R. Roberts.
  • Targeted therapy for non-small-cell lung cancer / Arun Rajan & Giuseppe Giaccone -- Overview of pathophysiology and drug targets for non-small-cell lung cancer / Anish Thomas, Arun Rajan & Giuseppe Giaccone -- EGFR inhibitors and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- VEGF receptor inhibitors / Ariel Lopez-Chavez & Alan Sandler -- CTLA-4 inhibitor : ipilimumab for the treatment of NSCLC / Julie R. Brahmer -- VEGF receptor inhibitors / Kavitha Ramchandran, Millie Das & Heather Wakelee -- HGFR/MET and ALK inhibitors / Eunice L. Kwak -- Vaccines for lung cancer / Ronan J. Kelly -- Index.
  • Targeted therapy for renal cell carcinoma / Ronald M. Bukowski -- Overview of renal cell carcinoma pathways and drug targets / Bernard Escudier -- mTOR in renal cell cancer: modulator of tumor biology and therapeutic target / Piotr J. Wysocki -- VEGF inhibitors / Toni K. Choueiri & Ali R. Golshayan -- VEGFR/PDGFR inhibitors in RCC / Jean S.Z. Lee & Tim Eisen -- Next-generation immunotherapy: CTLA-4 and PD-1 inhibitors / Daniel Y.C. Heng -- EGF receptor inhibitors / Marine Gross-Goupil & Alain Ravaud -- Cytokines / Alexandra Leary, James M.G. Larkin & Lisa M. Pickering -- Vaccination / Robert J Amato -- Evidence-based therapy of non-clear-cell and sarcomatoid renal cell carcinoma / Elan Diamond, Naveed H. Akhtar, Scott T. Tagawa & David M. Nanus -- Bisphosphonates in renal cell carcinoma: palliation versus antitumor effects / Saby George & Roberto Pili -- Combination therapy and future directions in renal cell carcinoma / Bernard Escudier & Camillo Porta.
  • This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
  • Resistance to Targeted Therapies As a Result of Mutation(s) in the Target / Alexis B. Cortot and Pasi A. Jänne -- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies / Daniel Gioeli -- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry / Jason R. Neil and Forest M. White -- Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications / Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta and Emanuel F. Petricoin -- Using Phosphoflow® to Study Signaling Events of Subpopulations Resistant to Current Therapies / Omar D. Perez -- Mathematical and Computational Models in Cancer / Sudhir Chowbina, Kevin A. Janes, Shayn M. Peirce and Jason A. Papin -- Somatic Evolution of Acquired Drug Resistance in Cancer / John W. Pepper -- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer / Edward Gunther -- microRNA: A Potential Therapy Able to Target Multiple Cancer Pathways / Benjamin Kefas and Benjamin W. Purow -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance / Yun Dai and Steven Grant.
  • This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia.
  • "The thoroughly revised and expanded 4th edition of the bestselling "Teaching Atlas of Mammography" contains a significant number of new cases. Based on 40 years of experience, the superbly illustrated cases often show long-term follow-up of patients over a period of up to 25 years. Rather than starting with the diagnosis and demonstrating typical findings, the approach of this atlas is to teach the reader and allow him to practice through 154 paradigm cases: how to systematically review mammograms for even the most subtle hints of malignancy, and how to carefully analyze and evaluate the mammographic signs to reach the correct diagnosis. Still unique to this book is the correlation of imaging findings with the corresponding large thin-section and subgross, large thick-section (3D) histology to facilitate an understanding of the pathological processes leading to the mammographic appearances. This approach is the basis for a profound understanding of breast imaging because it is a direct and effective method of teaching differential diagnosis of benign and malignant breast diseases"--Provided by publisher.
  • Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.
  • Tele-oncology 2015
    1 Introduction -- 2 Overview and Background -- PART I -- Fields of application 3 The community: Early diagnosis and prevention -- 4 The hospital: Improving hospital care for people with cancer -- 5 Home-based care for a better quality of life: Treatment, monitoring and follow-up -- PART II -- Technical Issues 6 New technologies and new frontiers -- 7 The social web -- PART III -- Complex Scenarios and Special Settings -- 8 Rural and extreme rural settings -- 9 Tele-oncology in developing countries -- PART IV -- eLearning 10 Education and distant learning -- 11 Health education to improve prevention -- 12 Conclusions.
  • Methods of telomerase inhibition -- Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines -- hTERT knockdown in human embryonic kidney cells using double-stranded RNA -- RNA interference using a plasmid construct expressing a short-hairpin RNA -- Retrovirus-mediated RNA interference -- Telomerase inhibition and telomere targeting in hematopoietic cancer cell lines with small non-nucleosidic synthetic compounds (BIBR1532) -- Uses of telomerase peptides in anti-tumor immune therapy -- Establishing cell-based reporter systems for the analysis of hTERT expression -- Telomerase RNA inhibition using antisense oligonucleotide against human telomerase RNA linked to a 2',5'-oligoadenylate -- Knockdown of telomerase RNA using hammerhead ribozymes and RNA interference -- Evaluation of tankyrase inhibition in whole cells -- Inhibition of telomerase by targeting MAP kinase signaling -- Screening of telomerase inhibitors -- Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect.
  • "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. 4 of cover.
  • The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.
  • Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination.
  • Cancer Overview -- Introduction to Therapy Dogs -- Dogs as Cancer Detectors -- Dog Therapy with Cancer Treatment -- Adding Therapy Dogs to Your Cancer Treatment Team -- Incorporating Companion Dogs into Cancer Rehab: Emotional Support -- Incorporating Companion Dogs into Cancer Rehab: Benefits from Physical Exercise for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Dog-Themed Exercise Program for Cancer Patients -- Incorporating Companion Dogs into Cancer Rehab: Practical Tips for Adding a Dog into the Home During Cancer Treatment and Recovery -- Resources.
  • Thyroid cancer 2012
    The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.
  • "Thyroid cancer evaluation and treatment has enjoyed very little evolution in comparison with other disease management strategies. The standard treatment algorithms for thyroid cancer have varied only in response to major, though infrequent, biotechnological innovations. These resultant algorithm node insertions produced paradigm changes, but there has been little to advance the care of the patient with advanced thyroid cancer--until very recently. Perhaps the reasons for a relative lack of interest and scientific progress are the overwhelming likelihood of benignity among thyroid nodules, the overwhelmingly favorable clinical outcome even if a patient has thyroid cancer, and the overwhelming long time required for clinical follow-up of these cancer patients. Unfortunately, the problem now is that we may be overmanaging low-risk patients, and we have not achieved the clinical responses we would have liked with high-risk patients"--Provided by publisher.
  • Thyroid neoplasms 2005
    Gene rearrangements in thryoid cancer -- Molecular markers of thyroid nodules -- Ultrasound in the diagnosis and management of thyroid cancer -- Controversies in the use of radioiodine for remnant ablation and therapy of thyroid carcinoma -- Thyroglobulin measurements in thryoid cancer evaluation and surveillance -- The role of fluoro-deoxy glucose (FDG) positron emission tomorgraphy (PET) in the management of differentiated thyroid cancer -- Preclinical studies of chemotherapy for undifferentiated thyroid carcinoma -- Medullary thyroid carcinoma -- Thyroid neoplasms in children and adolescents.
  • There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells.
  • Phylogeny of the TRAF/math domain / Juan M. Zapata, Vanesa Martínez-García, and Sophie Lefebvre -- TRAF1 and its biological functions / Soo Young Lee and Yongwon Choi -- Physiological roles and mechanisms of signaling by TRAF2 and TRAF5 / Ping-Yee Billie Au and Wen-Chen Yeh -- TRAF3 and its biological function / Jeannie Q. He ... [et al.] -- TRAF4, the unique family member / Valérie Kedinger and Marie-Christine Rio -- Characteristics and biological functions of TRAF6 / Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama -- Ubiquitination and TRAF signaling / Gabriel Pineda, Chee-Kwee Ea and Zhijian J. Chen -- Structural revelations of TRAF2 function in TNF receptor signaling pathway / Jee Y. Chung ... [et al.] -- Protein-protein interactions in TRAF3 / Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu -- Molecular basis for the unique specificity of TRAF6 / Jee Y. Chung ... [et al.] -- TRAF proteins in CD40 signaling / Gail A. Bishop ... [et al.] -- TRAFs in rank signaling / Bryant G. Darnay ... [et al.] -- The LT[beta]R signaling pathway / Paula S. Norris and Carl F. Ware -- LMP1 trafficking activates growth and survival pathways / Vishal Soni, Ellen Cahir-McFarland and Elliott Kieff -- Targeting TRAFs for therapeutic intervention / Juan M. Zapata, Sophie Lefebvre and John C. Reed.
  • Preface -- 1 Position of the patient -- 2 Steps shared by Total and Subtotal Gastrectomy -- 3 Total Gastrectomy -- 4 Manual Subtotal Gastrectomy.- 5 Stapled Subtotal Gastrectomy -- 6 Proximal Gastrectomy -- 7 Total and Subtotal D2 Laparoscopic Gastrectomy.- 8 Lymphadenectomy -- 9 Special Cases.
  • Use of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors' experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea, and esophagus, and miscellaneous items including the role of robotic surgery.
  • This book discusses in depth the transdisciplinary integration of different components of care in colorectal surgery. Pertinent background information on the complexities of current management in colorectal surgery is first provided, followed by discussion of the role of design thinking in care integration. Subsequent chapters focus on a range of issues associated with surgical and perioperative care in patients undergoing colorectal surgery, with emphasis on how the multiple facets of care can be integrated through a transdisciplinary approach. Each chapter provides helpful take-home messages in bullet point form and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, oncologists, nurses, and allied health professionals with extensive experience in the field.
  • v. 2 2008 Springer
    v. 1. Basic and clinical biology -- v. 2. Cancer treatment and therapy.
  • Lung cancer is the leading cause of cancer death in both men and women in the United States, and male Veterans seeking care at VA hospitals have a much higher age-specific incidence of lung cancer than males in the general population. The personal and economic significance of lung cancer has led to a vast research endeavor to try and identify new and more effective treatments. Most patients with lung cancer are diagnosed when the cancer is already advanced (stage IIIB or IV), and they are no longer candidates for surgical resection. Small cell lung cancer and non-small cell lung cancer (NSCLC) are different diseases in terms of treatment. Until recently, all therapies for advanced NSCLC were based on their cytotoxic properties. In the last few years, several novel agents aimed at specific molecular targets have been developed. This review was requested to evaluate the current evidence on the effectiveness and cost-effectiveness of treatments for advanced lung cancer.
  • This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authorsℓ́ℓ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.
  • Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.
  • "With the advent of computer technology and medical imaging, treatment planning in radiation oncology has evolved from a way of devising beam arrangements to a sophisticated process whereby imaging scanners are used to define target volume, simulators are used to outline treatment volume, and computers are used to select optimal beam arrangements for treatment. As such, this book is designed to provide a comprehensive discussion of the clinical, physical, and technical aspects of treatment planning. The intent of Treatment Planning in Radiation Oncology is to review these methodologies and present a contemporary version of the treatment planning process"--Provided by publisher.
  • Part I. Molecular bases for stem and cancer cells proliferation -- An introduction to proliferation and migration of stem cells and cancer -- the role of cell adhesions, cell junctions and extracellular matrix in normal development and carcinogenesis -- The embryonic rest hypothesis of cancer development: 150 years later -- Are calcium channels more important than calcium influx for cell proliferation?- Role of calcium signaling in stem cells and cancer cells proliferation -- Formation and function of lipid droplets in inflammation and cancer -- The role of sphingolipids in modulating pluripotency of stem cells -- Part II. Signaling pathways to cancer cells fate -- Signaling pathways of cbl-b and its role on peripheral t cell tolerance -- Bh3-only proteins in cancer and apoptosis -- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis -- Signalling pathways of [beta]-catenin/jnk on carcinogenesis -- The regulation of the jnk cascade and programmed cell death by nf- b: mechanisms and functions -- Part III. Uncontrolled physiology process guiding to cancer cells -- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors -- Autophagy, cell death, and cancer -- The duality of stem cells: double edged sword in tumour evolution and treatment -- Glioblastoma stem cells and implications for chemoresistance -- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions -- Tumor-associated neutrophils (tans) -- Microrna control of apoptotic programs in cancer -- Part IV. Therapeutic strategies for anticancer treatment -- Markers of cancer stem cells and their functions -- Cancer cell dormancy: potential therapeutic targets to eradicate cancer cells within the niche -- Modulating apoptosis in cancer therapy with ultrasound and high intensity nanosecond electric pulses -- Targeting cell cycle for anticancer treatment and neuroprotection.
  • PUBLIC HEALTH ASPECTS -- Geography and socioeconomics of the tropical areas -- Epidemiology of cancer in the tropical areas -- Management of cancers in countries with limited resources -- Access to Expensive drugs and Ethical considerations -- Precarity, social organization and outcome on cancer management in the tropical areas -- Cancer screening and prevention in the tropical areas -- Pathology and cancer research -- Cancer perception in different cultures of the tropical areas ; Cross-cultural mediation -- Cancer clinical trials in the tropical area -- BASIC SCIENCE BACKGROUND -- Spectrum of cancers due to micro-organisms (virus, bacteria, parasites) -- HIV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HIV -- HTLV1 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HTLV1 -- Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HBV -- Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HCV -- EBV and cancer; scientific background: Epidemiology of EBV and mechanisms of carcinogenesis -- HPV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HPV -- HHV8 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HHV8 -- Parasites and cancer: Epidemiology and mechanism of carcinogenesis of schitosoma -- Helicobacter and cancer: Epidemiology of Helicobacter Pylori and mechanisms of carcinogenesis -- HEMOPATHIES -- ATL (lymphoma et leukemia) -- Extranodal NK/T-cell lymphoma, nasal type -- High-grade lymphomas: Diffuse large B-cells lymphomas (with a special paragraph on CNS lymphomas) -- High-grade lymphomas: Burkitt lymphoma; Physiopathology and treatment of EBV associated lymphomas -- Mantle cell lymphoma -- Indolent lymphomas, follicular lymphomas, HVC associated marginal zone B-cell lymphomas and Waldenström disease -- Chronic myeloproliferative syndroms -- Myelodysplasic syndroms -- Acute leukemias -- CANCERS -- Breast cancer -- Cervix cancer -- Oesophageal cancer -- Gastric cancer -- Colorectal cancer -- Hepatocarcinoma -- Cholangiocarcinoma -- Pancreas cancer -- Lung cancer -- Head and neck cancers -- Bladder cancer -- Prostate cancer -- Renal cancer -- Cutaneous cancers (including melanoma) -- Ovarian cancer -- Endometrial cancer -- Cancer of the penis, anus and vulva -- Gestational trophoblastic tumors -- CNS tumors -- Thyroid cancer -- Uncommon cancers -- CANCER TREATMENT IN TROPICAL AREAS -- Pediatric oncology -- Geriatric oncology -- Surgery -- Radiotherapy -- Medical treatments (chemotherapy, hormone therapy, targeted drugs) -- HIV and cancer treatments -- Supportive cares -- Palliative cares.
  • Ptie 1. Contexte général des tumeurs rares -- ptie 2. Formes rares de tumeurs ubiquitaires et contextes rares de cancers -- ptie 3. Autres tumeurs rares par site.
  • Effect of Chemotherapy on the Tumor Microenvironment and Anti-tumor Immunity / Tarek M. Meniawy, Anna K. Nowak and Richard A. Lake -- Hyperthermia, the Tumor Microenvironment and Immunity / Stuart K. Calderwood -- Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ Tumor Vaccines / Stefan Nierkens, Martijn H. den Brok, Theo J. Ruers and Gosse J. Adema -- High Intensity Focused Ultrasound (HIFU) Ablation / Feng Wu -- The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects / Michael S. Sabel -- In situ Tumor Ablation with Radiation Therapy: Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / William H. McBride and Dörthe Schaue -- Tumor-Localized Insult Delivered by Photodynamic Therapy and the Breakdown of Tumor Immunotolerance / Mladen Korbelik -- In situ Ablation of Solid Tumors by Electric Forces and Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / Yona Keisari and Rafi Korenstein.
  • v.2, 2014 Springer
  • Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
  • Tumor microenvironment v. 1-, 2008-
  • This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe the influence of infiltrating cells of the immune system on tumor growth.
  • The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
  • Perspectives on the history and evolution of tumor models -- Murine L1210 and P388 leukemias -- Transplantable syngeneic rodent tumors: solid tumors in mice -- B16 murine melanoma: historical perspective on the development of a solid tumor model -- Human tumor xenograft efficacy models -- Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time -- Patient-derived tumor models and explants -- The pediatric preclinical testing program -- Imaging efficacy in tumor models -- Mammary cancer in rats -- Animal models of melanoma -- Experimental animal models for investigating renal cell carcinoma pathogenesis and preclinical therapeutic approaches -- Animal models of mesothelioma -- The use of mouse models to study leukemia/lymphoma and assess therapeutic approaches -- Spontaneous companion animal (pet) cancers -- Genetically engineered mouse models of pancreatic ductal adenocarcinoma -- Transgenic adenocarcinoma of the mouse prostate: a validated model for the identification and characterization of molecular targets and the evaluation of therapeutic agents -- The utility of transgenic mouse models for cancer prevention research -- Models for evaluation of targeted therapies of invasive and metastatic disease -- Animal models of toxicities caused by anti-neoplastic therapy -- Bone marrow as a critical normal tissue that limits drug dose/exposure in preclinical models and the clinic -- Anesthetic considerations for the study of murine tumor models -- Preclinical tumor response end points -- Tumor cell survival -- Apoptosis in vivo -- Transparent window models and intravital microscopy: imaging gene expression, physiological function and therapeutic effects in tumors.
  • I. Investigations -- Neurophysiology / Allen E. Waziri, Derek A. Taggard and Vincent C. Traynelis -- Neuroradiology and Ultrasound / David G. Hughes and Roger A. Chisholm -- Neuropathology / Cheng-Mei Shaw and Ellsworth C. Alvord -- II. Perioperative Care -- Neuroanesthesia / Maryke A. Kraayenbrink and Gregory R. McAnulty -- Neurosurgical Intensive Care / Tessa L. Whitton and Arthur M. Lam -- III. Techniques -- Neuroendoscopy / Jonathan Punt -- Principles and Practice of Image-guided Neurosurgery / Kristian Aquilina, Philip Edwards and Anthony Strong -- Stereotactic Radiosurgery / Andras A. Kemeny, Matthias W. R. Radatz and Jeremy G. Rowe -- IV. Tumors -- Low-grade Gliomasin Adults / Henry Marsh -- Neurosurgical Management of High-grade Gliomas / Robert C. Rostomily, Alexander M. Spence and Daniel L. Silbergeld -- Sellar and Parasellar Tumors / Richard J. Stacey and Michael P. Powell -- Meningiomas / James J. Evans, Joung H. Lee, John Suh and Mladen Golubic -- Intraventricular and Pineal Region Tumors / Sandeep Kunwar, G. Evren Keles and Mitchell S. Berger -- Cerebello-pontine Angle Tumors / Peter C. Whitfield and David G. Hardy -- Skull Base Tumors / Richard S. C. Kerr and Christopher A. Milford -- Tumors: Cerebral Metastases and Lymphoma / Sepideh Amin-Hanjani and Griffith R. Harsh -- Pediatric Neuro-oncology / Kevin L. Stevenson, J. Russell Geyer and Richard G. Ellenbogen -- Management of Spinal Tumors / Karl F. Kothbauer, George I. Jallo and Fred J. Epstein -- Management of Extradural Spinal Tumors / David A. Lundin, Charlie Kuntz and Christopher I. Shaffrey.
  • Lifestyle and Medical Approaches to Cancer Prevention / Peter Greenwald, p. 1-15 -- Application of Genetics to the Prevention of Colorectal Cancer / John Hopper, p. 17-33 -- Genetics and Prevention of Oesophageal Adenocarcinoma / Rebecca Fitzgerald, p. 35-46 -- Preclinical Models Relevant to Diet, Exercise, and Cancer Risk R. James Barnard and William Aronson, p. 47-62 -- Individualizing Interventions for Cancer Prevention / Michael Pollak, p. 63-70 -- Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials? / Ernest Hawk, Asad Umar, Ronald Lubet, Levy Kopelovich and Jaye Viner, p. 71-88 -- Problems with Using Biomarkers as Surrogate End Points for Cancer: A Cautionary Tale / Arthur Schatzkin, p. 89-98 -- Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists? / William Armstrong, Thomas Taylor and Frank Meyskens, p. 99-112 -- How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner? / Frank Meyskens and Eva Szabo, p. 113-124 -- The Problems with Risk Selection; Scientific and Psychosocial Aspects / Anne-Renée Hartman, p. 125-144 -- Chemoprevention of Lung Cancer / Stéphane Vignot, Jean-Philippe Spano, Sylvie Lantuejoul, Fabrice André, Thierry Le Chevalier and Jean-Charles Soria, p. 145-165 -- Anti-nicotine Vaccination: Where Are We? / T. Cerny, p. 167-175 -- Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise / María Martínez, p. 177-211 -- Chemoprevention of Colorectal Cancer: Ready for Routine Use? / Nadir Arber and Bernard Levin, p. 213-230 -- Screening of Colorectal Cancer: Progress and Problems Sidney Winawer, p. 231-244 -- The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence / Paola Muti, p. 245-256 -- Innovative Agents in Cancer Prevention / Margaret Manson, Peter Farmer, Andreas Gescher and William Steward, p. 257-275 -- The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer / Silvia Franceschi, p. 277-297 -- Health Economics in the Genomic Age / Thomas Szucs, p. 299-313 -- Screening for Cancer: Are Resources Being Used Wisely? / Robert Kaplan, p. 315-334.
  • Tumor suppressor genes
    Springer Protocols
    v. 2 Springer Protocols
    v. 1 Pathways and isolation strategies -- v. 2 Regulation, function, and medicinal application.
  • During the last 20 years, it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on 'Tumor-associated fibroblasts and their matrix' as part of the series on "Tumor-Microenvironment" is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor developmen.
  • Cesar A. Moran and Saul Suster are internationally recognized experts in pulmonary pathology who present a coherent and consistent approach to interpretation and diagnosis. Through more than 900 stunning photographs and a consistent, user-friendly format, this resource provides quality guidance on the diagnostic problems you face in everyday practice. You'll get a host of innovative, practice-oriented features unavailable in any other text that streamline and facilitate diagnostic decision-making. Written by practitioners for practitioners, this visual resource is designed for quick and easy use.
  • Includes bibliographical references and index. Introduction -- Bone-forming tumors -- Cartilage-forming tumors -- Giant cell tumor -- Round cell tumor -- Fibrous tumors -- Fibrohistiocytic tumors -- Vascular Tumors -- Adamantinoma -- Notochordal tumors -- Leiomyosarcoma -- Adipocytic tumors -- Neurogenic tumors -- Phosphaturic mesenchymal tumor -- Metastatic carcinoma involving bone -- Tumor-like lesions and other conditions that simulate primary tumors.
  • Vol. 1. Gliomas: Glioblastoma (part 1) -- Vol. 2. Gliomas: Glioblastoma (part 2) -- Vol. 3. Brain tumors (part 1) -- Vol. 4. Brain tumors (part 2) -- Vol. 5. Astrocytomas, hemangioblastomas, and gangliomas -- Vol. 6. Spinal Tumors (Part 1) -- Vol. 7. Meningiomas and Schwannomas -- Vol. 8. Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma --Vol. 9. Lymphoma, supratentorial tumors, glioneuronal tumors, gangliogliomas, neuroblastoma in adults, astrocytomas, ependymomas, hemangiomas, and craniopharygiomas -- Vol. 10. Pineal, pituitary, and spinal tumors -- Vol. 11. Pineal, pituitary and, spinal tumors -- Vol. 12. Molecular mechanisms, children's cancer, treatments, and radiosurgery -- Vol. 13. Types of tumors, diagnosis, ultrasonography, surgery, brain metastasis, and general CNS diseases -- Vol. 14. Glioma, meningioma, neuroblastoma, and spinal tumors
  • Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research--the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.
  • Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.
  • Classification/Diagnosis of Brain Tumors Using Discriminant Function Analysis -- Neuronal Differentiation in the Adult Brain: CDK6 as the Molecular Regulator -- Prolactinomas: Role of VEGF, FGF-2 and CD31 -- Human Brain Tumor Growth: Role of Aquaporins -- Molecular and Functional Characterization of Human Adipocytes -- Inhibition of Neuroblastoma Progression by Targeting Lymphangiogenesis: Role of an Endogenous Soluble Splice-Variant of VEGFR-2 -- Hyperinsulinemia Tends to Induce Growth Without Growth Hormone in Children with Brain Tumors After Neurosurgery -- Childhood Brain Tumours: Proton Beam Therapy -- Pathogenesis of Medulloblastoma: Role of Molecular Genetic Alterations -- Medulloblastomas: Survival Differences Between Children and Adults -- Survivors of Childhood Cancer: Risk of Glioma and Meningioma Following Radiotherapy -- Survivors of Childhood Cancer: Risk of New Primary Neoplasms of the CNS -- Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics -- Atlas-Based Segmentation of Tumor-Bearing Brain Images -- Nonthermal Irreversible Electroporation as a Focal Ablation Treatment for Brain Cancer -- The Role of Whole Brain Radiation Therapy for Metastatic Brain Tumors -- Craniotomy for Intracranial Tumors: Role of Postoperative Hematoma in Surgical Mortality -- Pituitary Adenomas: Treatment Using the Endonasal Approach -- Intracranial Tumors: Treatment with Endoscopic Neurosurgery -- Incidence of Recraniotomy for Postoperative Infections After Surgery for Intracranial Tumors -- Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function -- Treatment of Brain Tumors: Electrochemotherapy -- Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection -- The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance -- Drugs for Primary Brain Tumors: An Update -- Neurosurgical Treatment for Brain Metastases: Clinical Features, Operative Strategies, Recurrence and Survival -- Image-Guided Radiosurgery for Hypothalamic Hamartomas -- Image-Guided Stereotactic Radiosurgery for Spinal Pathology -- Image-Guided Stereotactic Radiosurgery for Optic Nerve Sheath Meningiomas -- Brain Metastases: The Application of Stereotactic Radiosurgery and Technological Advances -- Treatment of Chordomas by Stereotactic Radiosurgery with a Linear Accelerator: Comparison with Other Modes.
  • Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.
  • v. 2, 2012 Springer
  • v. 4 Springer
  • Pt. 1. Astrocytomas : diagnosis and biomarkers -- pt. 2. Astrocytomas : therapy -- pt. 3. Astrocytomas : prognosis -- pt. 4. Hemangioblastoma -- pt. 5. Ganglioglioma.
  • This volume contains information on the diagnosis, therapy, and prognosis of spinal tumors. Various aspects of different major types of spinal tumors (astrocytomas, ependymomas, and oligodendroglioma) are discussed. Insights into the understanding of molecular pathways involved in tumor biology are explained. Classification of intradural spinal tumors, including the percentages of each of the three major types, is detailed. Symptoms, radiological features, and clinicopathological parameters of spinal cord tumors are explained. Diagnosis, outcome, and prognosis of primary spinal cord and oligodendroglioma are discussed. Diagnosis of some other spinal tumors (e.g., pilomyxoid and chordomas) is also explained. The useful role of neuroimaging in diagnosing spinal teratoid/rhabdoid and gangliogliomas is included. A wide variety of treatments of a number of spinal cord tumor types are presented in detail. Therapies discussed include chemotherapy, surgery, radiosurgery, stereotactic radiosurgery, Cyberknife stereotactic radiotherapy, standard radiation alone, and rhenium-186 intracavity radiation. Also are duiscussed embolozation and spondylectomy. The usefulness of transplantation of human embryonic stem cells-derived oligodendrocyte progenitors and motoneuron progenitors in the repair of injured spinal cord is emphasized. Symptoms of the advent of spinal tumors are pointed out. Introduction to new technologies and their applications to spinal cord tumor diagnosis, treatment, and therapy assessment are explained
  • This volume offers in-depth discussion of two types of brain tumors - meningioma and schwannoma - covering diagnosis, therapy, and prognosis. It covers molecular genetics, and such therapeutic methods as neurosurgery, gamma knife radiosurgery, and adjuvant radiation
  • With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective.
  • The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and glioneuronal tumors, gangliogliomas, neuroblastoma in adults, hemangioma, and ependymoma.The content introduces new technologies and their applications
  • Print Material
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    Specimen evaluation -- Nonmalignant fibroblastic and myofibroblastic tumors and tumor-like lesions -- Fibroblastic/myofibroblastic neoplasms with variable biologic potential -- Lipomatous tumors -- Smooth muscle tumors -- Tumors with skeletal muscle differentiation -- Vascular tumors -- Soft tissue tumors with cartilaginous or osseous differentiation -- Soft tissue tumors with epithelial differentiation -- Miscellaneous translocation sarcomas -- Miscellaneous tumors -- Cytopathology of soft tissue tumors and tumor-like lesions.
  • Tumors of the spine 2008
    Achieve optimal outcomes for your patients with this new multimedia reference. Organized by tumor then by region, this resource details diagnostic and therapeutic options for primary and malignant spinal tumors. Over 25 key procedures--including minimally invasive surgery--are presented in a concise, stepwise fashion, putting the key information you need right at your fingertips! Over 600 illustrations round out this exhaustive new reference. Keep up to date on the latest advances in diagnosis and therapy with discussions of the latest surgical techniques, including minimally invasive spine surgery. Chapter templating helps you understand the entire procedure as well as key aspects, pearls and pitfalls, before heading into the OR. Have all the information you need to make a diagnosis and plan patient management with oversized, full color clinical photos and line drawings that illustrate key diagnoses and surgical procedures.
  • Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. ...--Foreword.
  • Tyrosine kinase inhibitors for gastrointestinal stromal tumor / Peter Reichardt -- Gastrointestinal stromal tumor pathophysiology & drug targets / Eva Wardelmann -- Imatinib / Sebastian Bauer & Michael Montemurro -- Sunitinib / Wen Wen Shan & Charles D. Blanke -- Other tyrosine kinase inhibitors in clinical trials / Maria Debiec-Rychter & Sebastian Bauer -- Other tyrosine kinase inhibitors in development and future directions / Uwe Knippschild, Christian Peifer, Joachim Bischof & Klaus Kramer -- Index.
  • Cystic Pancreatic Neoplasms -- Classification / Giuseppe Zamboni -- Serous Cystic Neoplasms / Giuseppe Malleo, Giuseppe Zamboni, Marina Paini, Giovanni Marchegiani -- Mucinous Cystic Neoplasms / Giovanni Marchegiani, Riccardo Manfredi, Giuseppe Malleo, Isabella Frigerio -- Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms / Marina Paini, Giuseppe Zamboni, Riccardo Manfredi, Salvatore Paiella, Giuseppe Malleo -- Intraductal Papillary Mucinous Neoplasms / Isabella Frigerio, Giuseppe Zamboni, Riccardo Manfredi, Antonio Pea, Silvia Pennacchio -- The Role of the Oncologist in the Diagnosis and Management of Malignant Cystic Neoplasms / Alessandra Auriemma, Davide Melisi, Giampaolo Tortora -- Neuroendocrine Pancreatic Neoplasms -- Epidemiology and Clinical Presentation / Maria Vittoria Davì, Marco Toaiari, Giuseppe Francia -- Pathology and Genetics / Aldo Scarpa, Vincenzo Corbo -- Imaging / Roberto Pozzi Mucelli, Giovanni Foti, Luigi Romano -- Surgical Therapy / Rossella Bettini, Stefano Partelli, Stefano Crippa, Letizia Boninsegna, Massimo Falconi -- Functional Imaging and Peptide Receptor Radionuclide Therapy / Maria Chiara Ambrosetti, Duccio Volterrani, Federica Guidoccio, Lisa Bodei -- Targeted and Other Non-receptor-mediated Therapies / Sara Cingarlini, Chiara Trentin, Elisabetta Grego, Giampaolo Tortora -- Uncommon Pancreatic Solid Neoplasms -- Rare Variants of Ductal Adenocarcinoma of the Pancreas / Paolo Regi, Marco Dal Molin, Federica Pedica, Paola Capelli, Mirko D'Onofrio -- Rare Primary Tumors of the Pancreas / Marco Dal Molin, Paola Capelli, Mirko D'Onofrio, Ivana Cataldo, Giovanni Marchegiani -- Rare Secondary Tumors of the Pancreas / Giovanni Butturini, Marco Inama, Marco Dal Molin, Mirko D'Onofrio, Davide Melisi -- Primary Non-epithelial Tumors of the Pancreas / Marco Dal Molin, Paola Capelli -- Tumor-like Lesions of the Pancreas / Luca Frulloni, Antonio Amodio, Italo Vantini, Marco Dal Molin, Marco Inama.
  • Understanding Liver Cancer is a concise and up-to-date review, which discusses diagnosis, management, patient care, current and emerging therapies, and useful resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of liver cancer as well as a summary of current therapies will benefit from this succinct text.
  • Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. Its aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage andpatient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy are covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists, and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
  • Upper tract urothelial carcinoma : ureteroscopic biopsy and specimen preparation / Demetrius H. Bagley, Ryuta Tanimoto, and Kelly A. Healy -- Imaging of upper tract transitional cell carcinoma / Sarah L. Steenbergen and Gary Israel -- Cytopathology and management of ureteroscopic biopsy samples / Shuye Ren and Marluce Bibbo -- Ureteroscopic treatment of upper urinary tract urothelial malignancy / Michael Grasso III, Bobby S. Alexander, Lynn J. Paik, and Andrew I. Fishman -- Surgical management of upper tract urothelial carcinoma- open, laparoscopic, and robotic approaches to nephroureterectomy and outcomes / Marc J. Mann, Costas D. Lallas, and Edouard J. Trabulsi -- Surveillance after treatment for upper tract transitional cell carcinoma / Michael J. Conlin and Brian D. Duty -- Topical chemotherapy / John Michael Henderson and Francis X. Keeley Jr. -- Systemic chemotherapy for upper tract urothelial cancer / Jean Hoffman-Censits -- Hereditary upper tract urothelial carcinoma : Lynch syndrome, hereditary nonpolyposis colorectal cancer syndrome (HNPCC) / Scott G. Hubosky and Bruce M. Boman -- Bladder tumors : association with upper tract neoplasms / Christopher B. Anderson, John E. Musser, John P. Sfakianos, and Harry W. Herr -- Enhanced imaging : NBI, PDD, SPIES / Luca Villa, Jonathan Cloutier, and Olivier Traxer -- Beyond endoscopy- ultrasound, optical coherence tomography and confocal laser endomicroscopy / Mieke T.J. Bus, Daniel Martin de Bruin, Guido M. Kamphuis, Theo M. de Reijke, and Jean J.M.C.H de la Rosette -- Diagnostic and treatment algorithm of upper tract urothelial carcinoma / Andrew I. Fishman, Lynn J. Paik, and Michael Grasso III.
  • Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.
  • Part 1. Prostate Cancer -- 1. Epidemiology, Etiological factors, Prevention -- 2. PSA Biology and Prostate Cancer Screening -- 3. Symptoms, Signs, Clinical Examination, Primary Diagnostic Methods and Disease Extention Investigations -- 4. Prostate Cancer Treatment.- Part 2. Bladder tumour -- 5. Epidemiology, Pathology, Etiological factors, Prevention, Screening, Symptoms and Signs -- 6. Investigations (Lab and Radiology) -- 7. Bladder Tumour Treatment -- 8. Non-Urothelial Bladder Cancers -- Part 3. Upper Tract Urothelial Carcinomas -- 9. Epidemiology, Risk Factors, Pathology, Tumour Staging -- 10. Diagnosis of UTUC -- 11. Treatment of UTUC, Prognosis and Follow-Up -- Part 4. Renal Cell Carcinomas -- 12. Epidemiology, Etiology -- 13. Pathology, Genetic Profile, Hereditary Syndromes -- 14. Clinical Features -- 15. Physical Examination, Laboratory and Radiological Investigations -- 16. Treatment of Renal Cell Carcinomas.- Part 5. Male Genital Cancer -- 17. Epidemiology and Etiology of Testicular Cancer -- 18. Histological Classification of Testicular Cancer -- 19. Clinical Presentation of Testicular Tumours and Spreading Patterns.- 20. Diagnostic Approaches of Testicular Cancer -- 21. Staging and Risk Categories of Testicular Cancer -- 22. Treatment of Testicular Cancer -- 23. Extra-Gonadal Germ Cell Tumours -- 24. Penile Cancer.- Part 6. Adrenal Gland Cancer -- 25. Epidemiology, Aetiological Factors, Symptoms and Signs of Adrenocortical Carcinomas (ACC) -- 26. Investigations of ACC -- 27. Treatment of Adrenal Gland Cancer -- 28. Malignant Pheochromocytoma -- Part 7. Clinical Scenarios -- 29. Scenarios and Questions -- 30. Proposed Answers.
  • Urological cancers 2005
  • With a fully updated look at urological cancers and a comprehensive approach to the basic principles behind chemotherapy, radiotherapy and gene therapy, Urological Oncology, 2nd Edition addresses the advances in MRI, hormone therapy, anesthesia for minimally invasive surgery, drug trials, new therapeutic techniques as well as the new histological types of renal cancer, bringing this second edition fully up-to-date with current practices. Through investigations and multidisciplinary management, Urological Oncology, 2nd Edition reflects the editors? vast experience in treating all urological cancers, and the broad international contributions reflect the urological oncology practice in other developed countries including the United States. Urological Oncology, 2nd Edition will be a valuable tool for residents, specialists, nurse practitioners and other medical personnel in Urology, Radiotherapy, Oncology and Palliative Medicine involved in the treatment of urological cancers.
  • Nonneoplastic disease of the prostate -- Neoplastic disease of the prostate -- Seminal vesicles -- Nonneoplastic disease of the urinary bladder -- Neoplastic disease of the urinary bladder -- Nonneoplastic disease of the kidney -- Neoplastic disease of the kidney -- Renal pelvis and ureter -- Nonneoplastic disease of the testis -- Neoplastic disease of the testis -- Spermatic cord and testicular adnexa -- Disease of the penis, urethra, and scrotum -- Soft tissue tumors and lymphomas.
  • Essential epidemiology of cancer of the endometrium -- Endometrial cancer: screening, diagnosis, and surgical staging -- Imaging in the diagnosis and treatment of endometrial cancer -- Uterine cancer: pathology -- Molecular pathology and cytogenetics of endometrial carcinoma, carcinosarcoma, and uterine sarcomas -- Prognostic factors in uterine cancer -- Primary hormonal therapy of endometrial cancer -- Early-stage endometrial cancer: surgery -- Early-stage endometrial cancer: radiation -- Therapeutic modalities in early-stage uterine papillary serous carcinomas, carcinosarcomas, clear-cell and mixed histology carcinomas: building a case for combined chemotherapy and radiation -- Treatment of advanced and recurrent carcinoma: hormonal therapy -- Treatment of advanced and recurrent carcinoma: chemotherapy -- Treatment for advanced and recurrent carcinoma: combined modalities -- Management of uterine sarcomas -- Future directions: new targets.
  • Part 1. Pre-clinical development -- The Discovery and Characterisation of Tumour Endothelial Markers / Dario Neri and Roy Bicknell -- The Use of Animal Models in the Assessment of Tumour Vascular Disrupting Agents (VDAs) / R. Barbara Pedley and Gillian M. Tozer -- Combination Therapy with Chemotherapy and VDAs / Giulia Taraboletti, Katiuscia Bonezzi and Raffaella Giavazzi -- Lessons from Animal Imaging in Preclinical Models / Lesley D. McPhail and Simon P. Robinson -- Combining Antiangiogenic Drugs with Vascular Disrupting Agents Rationale and Mechanisms of Action / Yuval Shaked, Paul Nathan, Laura G. M. Daenen and Robert S. Kerbel -- Development of Vascular Disrupting Agents / Graeme J. Dougherty and David J. Chaplin -- Part 2. Imaging in the development of vascular disruptive agents -- MRI to Assess Vascular Disruptive Agents / Martin Zweifel and Anwar R. Padhani -- Contrast Ultrasound in Imaging Tumor Angiogenesis / Grzegorz Korpanty and Rolf A. Brekken -- Part 3. Clinical development -- The Clinical Development of Tubulin Binding Vascular Disrupting Agents / Martin Zweifel and Gordon Rustin -- ASA404 (DMXAA): New Concepts in Tumour Vascular Targeting Therapy / Bruce C. Baguley -- Vascular Disruptive Agents in Combination with Radiotherapy / Henry C. Mandeville and Peter J. Hoskin.
  • Cruciferous vegetables and biological activity of isothiocyanates and indoles -- Green leafy vegetables in cancer prevention -- The role of tomato lycopene in cancer prevention -- [Beta]-carotene and other carotenoids in cancer prevention -- The role of alliums and their sulfur and selenium constituents in cancer prevention -- Molecular mechanisms of chemoprevention with capsaicinoids for chili peppers -- Influence of dietary soy isoflavones genistein and daidzein on genotoxicity and mammary carcinogenicity in rats exposed to the model carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA) -- The potential roles of seeds and seed bioactives on the prevention and treatment of breast and prostate cancer -- Nuts as part of a whole diet approach to cancer prevention -- Whole grains and their constituents in the prevention of colon cancer.
  • pt. 1. History and anatomy -- pt. 2. Preoperative assessment -- pt. 3. Embolization techniques -- pt. 4. Clinical outcomes -- pt. 5. Additional strategies for resection and embolization -- pt. 6. Evidence and the future.
  • Clathrin-Mediated Endocytosis / Alexander Sorkin, Manojkumar A. Puthenveedu -- Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton / Tal Hirschhorn, Marcelo Ehrlich -- Oncogenic Signaling from the Plasma Membrane / Eli Zamir, Nachiket Vartak, Philippe I. H. Bastiaens -- Endocytosis in the Spatial Control of Polarised Cell Functions / Giorgio Scita, Andrea Disanza, Emanuela Frittoli -- Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer / Shreya Mitra, Gordon B. Mills -- Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer / Crislyn D'Souza-Schorey, Guangpu Li -- Efficient Enhancement of Signaling Capacity: Signaling Endosomes / Iwona Pilecka, Marta Miaczynska -- Nuclear Functions and Trafficking of Receptor Tyrosine Kinases / Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung -- Efficient Enhancement of Signalling Capacity: The Ubiquitin System / Daniela Hoeller, Ivan Dikic -- Molecular Mechanism of Ubiquitin-Dependent Traffic / Elena Maspero, Hans-Peter Wollscheid, Simona Polo -- Cbl as a Master Regulator of Receptor Tyrosine Kinase Trafficking / Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz -- Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes / Han Liu, Sylvie Urbé, Michael J. Clague -- RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer--Location Counts / Carine Joffre, Rachel Barrow, Ludovic Ménard -- Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells / Sergio Anastasi, Stefano Alemà, Oreste Segatto MD -- Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress / Tzipora Goldkorn, Simone Filosto, Samuel Chung -- Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion / Elena Rainero, Peter V. E. van den Berghe, Jim C. Norman -- Antibody-Mediated Receptor Endocytosis: Harnessing the Cellular Machinery to Combat Cancer / Gabi Tarcic, Yosef Yarden.
  • "This book presents a variety of vibrational spectroscopic techniques, focusing on Raman and Fourier transform infrared (FTIR) spectroscopy and their use in noninvasive optical tissue diagnosis. It covers the most recent research in this area to create a unique database of different chemical bands and their assignments of spectral bands. The text explores the spectroscopic investigation of different tissues and samples, including breast tissue, lung tissue, and brain tissue. Based on their years of experience with various applications, the authors provide definitions of peak frequencies as well as other aspects of spectroscopy that could be helpful to a wide range of scientists"--Provided by publisher.
  • Why we do CTC : screening for colorectal cancer / Richard M. Mendelson -- The performance of CTC / Didier Bielen -- Starting CT colonography in your department / Darra Murphy, Alan O'Hare, and Helen Fenlon -- The eligible patient : indications and contraindications / M. Raquel Oliva, Ayodale S. Odulate, and Koenraad J. Mortele -- Patient preparation for CT colonography / J. Yee -- The prerequisite : faecal tagging / Philippe Lefere and Stefaan Gryspeerdt -- How to get the colon distended? / David Burling, Stuart Taylor, and Steve Halligan -- Right parameters / Andrea Laghi -- How to interpret CTC data : evaluation of the different lesion morphologies / Beth G. McFarland -- How to avoid pitfalls in imaging : causes and solutions to overcome false-negatives and false-positives / Stefaan Gryspeerdt and Philippe Lefere -- 3D imaging : invaluable for the correct diagnosis? / Ayso H. De Vries and Jaap Stoker -- The challenge : detection of early-stage superficial colorectal lesions -- Gen Iinuma ... [et al.] -- Extracolonic findings / Francesca Turini, Francesca Cerri, and Emanuele Neri -- The future : computer-aided detection / H. Yoshida -- Quality and consistency in reporting CT colonography / Abraham H. Dachman, Piotr R. Obara, and Michael E. Zalis -- Virtual colonoscopy : beyond polyp detection? / T. Mang ... [et al.] -- Pictorial overview of normal anatomy, mimics of disease, and neoplasia using CT colonography / J.G. Fletcher, Fargol Booya, and Luis S. Guimaraes.
  • Human Cancer Virology: An Historical Review -- Epstein-Barr Virus: Pathogenesis and Host Immune Response -- Epstein-Barr Virus: Epidemiology and Clinical Features of Related Cancer -- Hepatitis C Virus: Pathogenesis and Host Immune Response -- Hepatitis C Virus: Epidemiology and Clinical Features of Related Cancer -- Hepatitis B Virus: Pathogenesis and Host Immune Response -- Hepatitis B Virus: Epidemiology and Clinical Features of Related Cancer -- Human Papillomavirus: Pathogenesis and Host Immune Response -- Human Papillomavirus: Epidemiology and Clinical Features of Related Cancer -- Human T-Cell Leukemia Virus Type 1: Pathogenesis and Host Immune Response -- Human T-Cell Leukemia Virus Type 1: Epidemiology and Clinical Features of Related Cancer -- Kaposi's Sarcoma-Associated Herpesvirus: Pathogenesis and Host Immune Response -- Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Clinical Features of Related Cancer -- Merkel Cell Polyomavirus: Pathogenesis and Host Immune Response -- Merkel Cell Polyomavirus: Epidemiology and Clinical Features of Related Cancer.
  • This book uses a pattern-recognition approach to help you diagnose challenging musculoskeletal tumors with confidence. With an easy-to-use format, it is the only resource that correlates histology studies and imaging studies. By comparing images these superb-quality, large-scale images, you can master pattern recognition for the 30 most important musculoskeletal tumors and make informed, effective, and rapid decisions on diagnosis and treatment.
  • 1. Vitamin D: synthesis and catabolism- considerations for cancer causation and therapy -- 2. The molecular cancer biology of the VDR -- 3. Anti-inflammatory activity of calcitriol in cancer -- 4. The epidemiology of Vitamin D and cancer risk -- 5. Vitamin D and angiogenesis -- 6. Vitamin D: cardiovascular function and disease -- 7. Induction to differentiation in cancer cells by Vitamin D: recognition and mechanisms -- 8. Vitamin D and cancer chemoprevention -- 9. Molecular biology of Vitamin D metabolism and skin cancer -- 10. Vitamin D and prostate cancer -- 11. Vitamin D and hematologic malignancies -- 12. The Vitamin D signaling pathway in mammary gland and breast cancer -- 13. Vitamin D and colorectal cancer -- 14. Unique features of the enzyme kinetics for the Vitamin D system, and the implications for cancer prevention and therapeutics -- 15. Assessment of Vitamin D status in the 21st century -- Index.
  • Negotiating personal and political settlements with breast cancer: women finding their own ways to live with human contingency / Rosemarie Tong -- Personalizing the political: negotiating the feminist, medical, scientific and commercial discourses surrounding breast cancer / Susan Sherwin -- Power, gender, and pizzazz: the early years of breast cancer activism / Barron Lerner -- Breast cancer: dueling discourses and the persistence of an outmoded paradigm / Gwynne Gertz -- Doing things with ideas and affects in the illness narratives of Susan Sontag and Eve Kosofsky Sedgwick / Lisa Diedrich -- The breast cancer diaries / Anita Ho -- Breast cancer: the maternal body reflected in a three-way mirror / Debra Gold -- Learn to love what's left: poems on breast cancer / Leatha Kendrick -- Death and the other: rethinking authenticity / Gail Weiss -- Breast cancer research: a political cause and paradigm for scientific inquiry / John S. Kovach -- Clinical trials for breast cancer and informed consent: how women helped make research a cooperative venture / Loretta M. Kopelman -- The role of psychosocial research in understanding and improving the experience of breast cancer and breast cancer risk / Anne Moyer and Marci Lobel -- Teaching about breast cancer and "common health" / Helen Rodnite Lemay -- Theoretical considerations on "reading" the breast / Tanfer Emin-Tunc -- Recent developments in breast cancer research / Sofya Maslyanskaya.
  • This book represents a daring and rarely attempted endeavor to bridge the gap between histopathology and molecular medicine in that cutting-edge molecular findings are seamlessly integrated into the key morphological features. This volume also includes discussions of short lists of organ-based benign lesions with concerning morphological features. Presented in the differential diagnosis section, they will not only serve as useful checklists for the surgical pathologist who is seriously contemplating a diagnosis of malignancy due to the observation of some cytological or histological atypia, but also help hone the key features of each malignant atypia. Well-Differentiated Malignancies: New Perspectives provides an innovative resource on the difficult topic of well-differentiated malignancies for pathology residents, fellows and for those already in clinical practice.
  • The purpose of this book is twofold: First, it provides an up-to-date overview of the field of surgical oncology for surgeons in training. Particular attention is devoted to the principles of surgery, but important aspects of radiation and medical oncology are also discussed. Furthermore, diagnostic, staging, and treatment algorithms are presented that will offer invaluable assistance in management decision making. The second aim of the book is to offer a comprehensive reference source on the role of surgery in curative and palliative management for medical and radiation oncologists (in practice and in training) and other healthcare professionals involved in the care of cancer patients. The full range of cancer types is covered in a practical, multidisciplinary approach, and additional chapters are devoted to pediatric malignancies, the role of new surgical technologies, and surgical emergencies.
  • Astrocytic Tumours -- Oligodendroglial Tumours -- Ependymal Tumours -- Choroid Plexus Tumours -- Other Neuroepithelial Tumours -- Neuronal and Mixed Neuronal- Glial Tumours -- Tumours of the Pineal Region -- Embryonal Tumours -- Tumours of the Cranial and Paraspinal Nerves -- Meningeal Tumours -- Tumours of the Haematopoietic System -- Germ Cell Tumours -- Familial Tumour Syndromes involving the Nervous System -- Tumours of the Sellar Region --Metastatic Tumours of the CNS.
  • This manual presents a large collection of clinical cases in oncology with accompanying whole-body FDG PET-CT scans. The aim is to promote an integrated approach to the use of PET-CT, and detailed attention is therefore paid to the clinical history and diagnostic question. A central aspect of every clinical case described in this manual is the guidance on the clinical report, which is the official tool for communicating with both the referring physician and the person undergoing the diagnostic test; for this reason it needs to be clear, understandable, and written in shared language. The advice regarding report preparation is strongly supported by informative PET, CT, and PET-CT fused images of each disease. The book is broadly structured according to anatomic region, and a wide range of common diseases likely to be imaged using PET-CT is covered. This book will be of value to all those training or working in the field of oncology who wish to ensure that they are best placed to contextualize, interpret, and report the findings obtained with PET-CT, which can have such a dramatic impact on prognosis, therapeutic choice, and quality of life.
  • Epidemiology / David Neary -- Economic burden / Richard J. Butler, William G. Johnson, and Timothy Gubler -- Employers' and survivors' perspectives / Ziv Amir, David R. Strauser, and Fong Chan -- Work disability : it is not just the "lesion" / Patrick Loisel -- The meaning of work / Guy Maytal and John Peteet -- Fatigue, pain, and physical function / Mary E. Sesto and Maureen J. Simmonds -- Cognitive limitations / Tracy Veramonti and Christina Meyers -- Young survivors of childhood cancer / Angela de Boer, Jos Verbeek, and Frank van Dijk -- Primary and occupational health care providers / Jos Verbeek, Angela de Boer, and Taina Taskila -- Rehabilitation / Michael J.L. Sullivan ... [et al.] -- Workplace accomodations / Fong Chan ... [et al.] -- Individuals with cancer in the workforce and their federal rights / Peter Blanck ... [et al.] -- International efforts : perspectives, policies, and programs / Patricia Findley and Catherine P. Wilson -- Future research, practice, and policy -- Michael Feuerstein.
  • From DNA replication to genome instability in schizosaccharomyces pombe: pathways to cancer / Julie M. Bailis and Susan L. Forsburg -- Dissecting layers of mitotic regulation essential for maintaining genomic stability / Jeffiner S. Searle and Yolanda Sanchez -- Yeast as a tool in cancer research: nuclear trafficking / Anita H. Corbett and Adam C. Berger -- Studies of protein farnesylation in yeast / Nitika Thaper and Fuyuhiko Tamanoi -- From bread to bedside: what budding yeast has taught us about the immortalization of cancer cells / Soma S.R. Banik and Christopher M. Counter -- Hsp90 co-chaperones in saccharomyces cerevisiae / Marija Tesiccc and Richard F. Gaber -- Yeast as a model system for studying cell cycle checkpoints / Carmela Palermo and Nancy C. Walworth -- Metabolism and function of sphingolipids in saccharomyces cerevisiae: relevance to cancer research / L. Ashley Cowart, Yusuf A. Hannun, and Lina M. Obeid -- Exploring and restoring the p53 pathway using the p53 dissociator assay in yeast / Rainer K. Brachmann -- Functional analysis of the Human p53 tumor suppressor and its mutants using yeast / Alberto Inga, Francesca Storici and Michael A. Resnick -- ABC transporters in yeast - drug resistance and stress response in a nutshell / Karl Kuchler and Christoph Schüller -- The FHCRC/NCI yeast anticancer drug screen / Susan L. Holbeck and Julian Simon -- Yeast as a model to study the immunosuppressive and chemotherapeutic drug rapamycin / John R. Rohde, Sara A. Zurita-Martinez, and Maria E. Cardenas -- Use of yeast as a model of system for identifying and studying anti-cancer drugs / Jun O. Liu and Julian A. Simon -- Genetic analysis of cisplatin resistance in yeast and mammals / Seiko Ishida and Ira Herskowitz -- Using yeast tools to dissect the action of anti-cancer drugs: mechanisms of enzyme inhibition and cell killing: agents targeting DNA topoisomerases / Anna Rogojina, ... [et al].

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. 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