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Oncology

  • 2012 Springer
    Alfred Längler, Patrick J. Mansky, Georg Seifert, editors.
    This practice-oriented handbook covers complementary and alternative medicine (CAM) practices in pediatric oncology worldwide, with a focus on methods used in Western countries. Provides a road map for establishing integrative pediatric oncology worldwide.
  • 2015 Springer
    Yasumasa Nishimura, Ritsuko Komaki, editors.
    Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.
  • 2014 Springer
    Magdalena Klink, editor.
    The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
  • 2014 ScienceDirect
    Arseniy E. Yuzhalin, Anton G. Kutikhin.
    Introduction : basic concepts -- Interleukin-1 superfamily and cancer -- Interleukin-2 superfamily and cancer -- Interleukin-3, Interleukin-5, and cancer -- IL-6 family and cancer -- Interleukin-10 superfamily and cancer -- Interleukin-12 superfamily and cancer -- Interleukin-17 superfamily and cancer -- The rest of interleukins -- Concluding remarks.
  • 2013 Springer
    György Kovács, Peter Hoskin, editors.
    Prostate brachytherapy has been the subject of heated debate among surgeons and the proponents of the various brachytherapy methods. This very first interdisciplinary book on the subject provides a comprehensive overview of innovations in low dose rate (LDR), high dose rate (HDR), and pulsed dose rate (PDR) interstitial brachytherapy for the management of local or locally advanced prostate cancer. In addition to detailed chapters on patient selection and the use of imaging in diagnostics, treatment guidance, and implantation control, background chapters are included on related medical physics issues such as treatment planning and quality assurance. The results obtained with the different treatment options and the difficult task of salvage treatment are fully discussed. All chapters have been written by internationally recognized experts in their fields who for more than a decade have formed the teaching staff responsible for the successful GEC-ESTRO/EAU Prostate Brachytherapy Teaching Course. This book will be invaluable in informing residents and others of the scientific background and potential of modern prostate brachytherapy. It will also prove a useful source of up-to-date information for those who specialize in prostate brachytherapy or intend to start an interstitial brachytherapy service.
  • 2010 Thieme Book
    Uwe Fischer, Friedemann Baum ; with contributions by Friedemann Baum [and others].
  • 2015 Thieme-Connect
    [edited by] Ripal T. Gandhi, Suvranu Ganguli.
    Percutaneous ablation of renal cell carcinoma / Raul Uppot, Debra A. Gervais, and Shawn Ahmed -- Adrenal malignancy : ablation / Aradhana M. Venkatesan and Bradford J. Wood -- Ablation of lung cancer, pulmonary metastatic disease, and chest wall malignancy / Charles McGraw, Scott Genshaft, Fereidoun Abtin, Antonio Gutierrez and Robert Suh -- Hepatocellular carcinoma : ablation / Riccardo Lencioni -- Hepatocellular carcinoma : chemoembolization / Siddharth A. Padia and Matthew J. Kogut -- Hepatocellular carcinoma : radioembolization / Avnesh Thakor, Arash, Eftekhari, Ed Lee, Darren Klass, and David Liu -- Colorectal hepatic metastatic disease : ablation / Muneeb Ahmed -- Colorectal hepatic metastatic disease : intraarterial therapies / Govindanrajan Narayanan and Prasoon Mohan -- Carcinoid and neuroendocrine tumors : intraarterial therapies / Elena N. Petre, Karen T. Brown, and Constantinos T. Sofocleous -- Cholangiocarcinoma : ablation and intraarterial therapies / Paul J. Rochon, Charles E. Ray Jr., Rajan K. Gupta, and Matthew Brown -- Bone tumors : ablation / Matthew R. Callstrom and A Nicholas Kurup -- Portal vein embolization / Sanjeeva Kalva -- Emerging technologies (navigational systems, immunoembolization, percutaneous -- Hepatic perfusion/chemosaturation, ire) / Rahmi Oklu.
  • 2012 Springer
    Peter R. Mueller, Andreas Adam, editors.
    Interventional Oncology is a fast-growing new field, as well as an emerging specialty. Many minimally-invasive, imaging-guided procedures seem set to replace more traditional open surgical techniques of treating solid tumors in a variety of organs. The aim of this book is to describe new interventional radiological methods in a succinct and practical form. Diagnostic radiological considerations relevant to the selection and follow-up of patients are also covered. The book begins with an overview of the basic principles of current interventional techniques, including thermal ablation, high intensity focused ultrasound, and embolization. Later chapters focus on tumors of the liver, kidney, lung, and bone, placing new interventional techniques in context by referring to the surgical and oncologic methods of treating the same conditions. With an emphasis on best practices, Interventional Oncology: A Practical Guide for the Interventional Radiologist will serve as a definitive guide to practicing physicians involved in this rapidly evolving field.
  • 2013 Springer
    Timothy Clark, Tarun Sabharwal editors.
    The Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice.The series comprises a number of titles, which cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, ablation, pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice.Interventional Radiology Techniques in Ablation is a practical and concise guide to contemporary techniques in image-guided tumor ablation. This handbook is intended to serve as a quick reference for physicians in interventional radiology training as well as a resource for IR technologists, nurses, nurse practitioners and physician assistants.
  • 2013 Springer
    Jose Pablo Díaz-Jimenez, Alicia N. Rodriguez, editors.
    Interventions in Pulmonary Medicine is an important new volume that addresses all areas of interventional pulmonology, a minimally invasive endoscopic way to diagnose and treat lung disorders. This volume contains dedicated chapters that outline the many issues related to lung cancer, both in early and advanced stages, from diagnosis to personalized treatment. It also covers bronchoscopic therapeutic options to benign conditions that are highly prevalent, such as COPD and asthma. Techniques described in this volume are: laser therapy, argon plasma coagulation therapy, cryotherapy, brachytherapy, placement of intrapleural drainage systems, endoscopic treatment of emphysema, stents in the airway, and thermoplasty for bronchial asthma. Diagnostic procedures that are covered are: medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, electromagnetical navigation, and trends in personalized treatment for lung cancer and other benign lung conditions. Chapters are written by experts and the developers of the techniques that are currently considered gold standard. Evidence-based reviews are presented for all topics and indications, and contraindications are discussed. Interventions in Pulmonary Medicine is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.
  • 2014 Springer
    Masao Tanaka, editor.
    Intraductal papillary mucinous neoplasms (IPMNs) represent an opportunity to treat pancreatic tumors before they develop into aggressive, hard-to-treat cancers. Beginning with morphological classification and its clinical significance, natural history, and malignant change of both main duct and branch duct IPMNs, this book covers the whole field of IPMNs of the pancreas. It reviews the various methods of investigation: imaging, diagnostic investigation of cyst fluid, and those using pancreatic juice; and also examines aspects ranging from the development of malignancy to the timing and method of resection, focusing on both main duct and branch duct IPMNs. Aimed at residents, clinical fellows, and pancreatologists who treat patients with this common disease of the pancreas, this book is a landmark in the current understanding and future perspectives of IPMNs of the pancreas.
  • 2009 Springer
    Maode Lai, editor.
  • 2011 Springer
    edited by Leonard L. Gunderson, Christopher G. Willett, Felipe A. Calvo, Louis B. Harrison.
    General rationale and historical perspective -- Rationale and historical perspective of intraoperative irradiation -- Biology of large dose per fraction irradiation -- Methods and techniques of treatment -- Intraoperative electron beam irradiation: physics and techniques -- HDR-IORT: physics and techniques -- Electronic brachytherapy/low KV-IORT: physics and techniques -- IORT with electron-beam, high-dose-rate brachytherapy or low-KV/electronic brachytherapy: methodological comparisons -- Normal tissue tolerance: IORT -- Normal-tissue tolerance to IOERT, EBRT, or both: animal and clinical studies -- Results of IORT alone or plus EBRT by disease site -- Central nervous system tumors -- Head and neck cancer -- Breast cancer -- Lung cancer -- Gastric cancer -- Pancreas cancer -- Bile duct and gallbladder cancer -- Primary colorectal cancer -- Recurrent colorectal cancer -- Retroperitoneal sarcomas -- Extremity and trunk soft-tissue sarcomas -- Bone sarcomas -- Gynecologic malignancies -- Genitourinary cancer -- Pediatric malignancies -- Conclusions and future possibilities -- Conclusions and future possibilities: IORT.
  • 2011 Thieme eNeurosurgery
    [edited by] Walter A. Hall, Christopher Nimsky, Charles L. Truwit.
    "Intraoperative MR-Guided Neurosurgery contains detailed coverage of this state-of-the-art technology from the pioneers who developed it. World-renowned neurosurgeons and neuroradiologists combine their collective wisdom and experience to demonstrate how MR-guided neuronavigation can be used to view real-time images of a patient's brain during surgery to help remove tumors with greater precision. The authors provide step-by-step descriptions of how to perform procedures, including advice based on their clinical results. Readers will learn about the advantages and drawbacks of the various MR imaging systems, clinical indications for MR-guidance, anesthesia considerations, safety concerns related to working in a magnetic environment, and much more"--Provided by publisher.
  • 2012 Springer
    Cynthia T. Welsh, editor.
    This volume acquaints the non-neuropathologist with the advantages of clinical-radiologic-pathologic correlation in neuropathology specimens, particularly in the intra-operative environment. This volume covers the enormous and sometimes insurmountable artifacts involed with freezing tissue, especially central nervous system tissue and how a good cytology preparation can add to, or even supply in isolation, a diagnosis. The text presents how to perform, and stain the cytologic preparations, and how to interpret them. The advantages and disadvantages of both frozen sections and cytologic preparations of various kinds are discussed. The presentation and format is very visual with diagrams, tables (including pearls and pitfalls), and many figures (therefore easy reading).An introductory chapter presents the pros and cons of supplemental cytology, the advantages and disadvantages of frozen sections, and the artifacts in both. Also included is an argument for knowing what the scans reveal and the impact of relevant patient history. The volume uses a case-based approach to show correlation between scan, history, frozen section and cytologic preparations.With the combination of extensive correlation of scans, cytology and frozen section with differential diagnosis, and analysis of the information crucial to the neurosurgeon in a case-based approach and with a special chapter written by a neuroradiologist, this volume is unique in presentation and utility and will be of great value to the trainee in pathology (residents/fellows), and practicing pathologists who include neuropathology in their practice, but do not have formal fellowship training in neuropathology.
  • 2007 Springer
    edited by C. William Helm and Robert P. Edwards.
    Management of ovarian cancer : the theory / Maurie Markman -- Management of ovarian cancer : clinical trials / Maurie Markman -- A systematic review and meta-analysis of randomized trials / Kenneth Jaaback -- Immunobiology and intraperitoneal immunobiologics in ovarian cancer / Ralph S. Freedman -- Intraperitoneal chemotherapy : technique and complications / Joan L. Walker -- Hyperthermia and chemotherapy : the science / Roger A. Vertrees, Jeffrey M. Jordan, and Joseph B. Zwischenberger -- Hyperthermic intraperitoneal chemotherapy in nongynecologic cancers / Bing Yi, Jason M. Foster, and Brian W. Loggie -- Peritoneal carcinomatosis of colorectal origin / Frans A.N. Zoetmulder -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : experience in France / Olivier Glehen and Francois-Noel Gilly -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : world experience / C. William Helm -- Techniques of delivering hyperthermic intraperitoneal chemotherapy / Jesus Esquivel, Paul H. Sugarbaker, and C. William Helm -- Future directions in the delivery of hyperthermic intraperitoneal chemotherapy / Scott Richard and Robert P. Edwards.
  • 2010 Springer
    David S. Alberts, Mary C. Clouser, Lisa M. Hess (editors).
    Current chemotherapy of ovarian cancer -- Principles of intraperitoneal chemotherapy -- Intraperitoneal chemotherapy: phase III trials -- Criteria for using intraperitoneal (IP) chemotherapy for advanced ovarian cancer -- Selection and placement of intraperitoneal catheters for IP chemotherapy for ovarian cancer -- Selection of drugs for intraperitoneal chemotherapy for ovarian cancer -- Administration guidelines for intraperitoneal chemotherapy for ovarian cancer -- Novel drugs for intraperitoneal therapy for ovarian cancer -- Cytoreductive surgery and perioperative intraperitoneal chemotherapy: an ongoing research effort -- Health-related quality of life and patient-reported outcomes.
  • 2007 Springer
    PierFrancesco Bassi, Francesco Pagano, editors.
  • 2014 Springer
    Ricardo H. Bardales, editor.
    Chapter 1. Ultrasound, general considerations -- Chapter 2. The interventional cytopathologist -- Chapter 3. The thyroid gland -- Chapter 4. The parathyroid gland -- Chapter 5. The salivary glands -- Chapter 6. The head and neck, miscellaneous lesions -- Chapter 7. The lymph nodes -- Chapter 8. The breast -- Index.
  • 2007 WHO
    IPCS.
    The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
    Also available: Print – 2007
  • 2012 ClinicalKey
    Jatin P. Shah, Snehal G. Patel, Bhuvanesh Singh.
    Basic principles of head and neck surgery -- Scalp and skin -- Eyelids and orbit -- Nasal cavity and paranasal sinuses -- Skull base -- Lips -- Oral cavity -- Pharynx and esophagus -- Larynx and trachea -- Cervical lymph nodes -- Thyroid and parathyroid glands -- Salivary glands -- Neurogenic tumors and paragangliomas -- Soft tissue tumors -- Bone tumors, including odontogenic lesions -- Reconstructive surgery -- Oncologic dentistry, maxillofacial prosthetics, and implants -- Radiation therapy -- Chemotherapy.
  • 2016 Ovid
    editors, Faiz M. Khan, John P. Gibbons, Paul W. Sperduto.
  • 2015 Springer
    Primo N. Lara, Jr., Eric Jonasch, editors.
    Part 1: Epidemiology and Biology Epidemiology of Kidney Cancer -- Pathological Classification -- Molecular Biology of Kidney Cancer -- Biomarkers for Kidney Cancer -- Genetic Heterogeneity of Kidney Cancer -- Metabolic Basis of Kidney Cancer. Part 2: Clinical Considerations Clinical Presentation and Staging.- Hereditary Kidney Cancer. Part 3: Surgical and Local Control Modalities Surgical Approaches to Early Stage Kidney Cancer -- Cytoreductive Nephrectomy -- Metastasectomy -- Energy Ablative Techniques in Kidney Cancer -- The Role of Radiation Therapy in Kidney Cancer. Part 4: Systemic Therapy Considerations Adjuvant Systemic Therapy -- Cytokines and Vaccine Therapy -- PD1 and PDL1 Targeted Therapy -- Angiogenesis Inhibitor Therapy -- The Role of mTOR inhibitors and PI3K Pathway Blockade -- Sequential versus Combination Strategies -- Presurgical Therapy in Kidney Cancer -- Toxicity Management for Patients on Targeted Therapies -- Emerging Agents in Kidney Cancer.
  • 2012 Springer
    Primo N. Lara, Jr., Eric Jonasch, editors.
    "Kidney Cancer: Principles and Practice is an interdisciplinary textbook that encompasses all clinically relevant aspects of the disease and is designed to be as user-friendly as possible in order to meet the needs of the busy practitioner. To this end, the informative text is complemented by helpful boxed sections that present essential 'take home' points and patient-oriented cases demonstrating the clinical application of elements discussed in the chapter in question. Original high-quality images, some in color, are included whenever necessary to simplify particularly complex material. The authors are an international group of acknowledged experts in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others. This clinically oriented volume will be of great interest to clinicians, researchers, residents, and fellows, as well as to students and knowledgeable lay people."--Publisher's website.
  • 2005 Springer
    by Gideon Berke and William R. Clark.
    Also available: Print – 2005
  • 2009 Springer
    Peter De Wulf, William C. Earnshaw, editors.
    Centromeres and kinetochores : an historical perspective / Kerry S. Bloom -- The basics of chromosome segregation / Mitsuhiro Yanagida -- The centromere / Beth A. Sullivan -- Neocentromeres / Owen J. Marshall and K.H. Andy Choo -- Human artificial centromeres : de novo assembly of functional centromeres on human artificial chromosomes / Hiroshi Masumoto, Teruaki Okada, and Yasuhide Okamoto -- Kinetochore composition, formation, and organization / Tatsuo Fukagawa and Peter De Wulf -- Evolution of centromeres and kinetochores : a two-part fugue / Paul B. Talbert, Joshua J. Bayes, and Steven Henikoff -- Mitotic spindle assembly mechanisms / Rebecca Heald and Claire E. Walczak -- Kinetochore-microtubule interactions / Lesley Clayton and Tomoyuki U. Tanaka -- Post-translational modifications that regulate kinetochore activity / Chitra V. Kotwaliwale and Sue Biggins -- The role of the kinetochore in spindle checkpoint signaling / P. Todd Stukenberg and Daniel J. Burke -- Kinetochore regulation of anaphase and cytokinesis / Scott Thomas and Kenneth B. Kaplan -- Roles of centromeres and kinetochores in meiosis / Adele L. Marston -- The kinetochore-cancer connection / Takeshi Tomonaga -- The kinetochore as target for cancer drug development / Song-tao Liu and Tim J. Yen.
  • 2012 Springer
    Leopold G Koss, Rana S. Hoda.
    Indication, Collection, and Laboratory Processing of Cytologic Samples -- The Cellular and Acellular Components of the Urinary Sediment -- The Cytologic Makeup of the Urinary Sediment According to the Collection Technique -- Cytologic Manifestations of Benign Disorders Affecting Cells of the Lower Urinary Tract -- Tumors and Related Conditions of the Bladder and Lower Urinary Tract -- Urine-Based Assays Complementing Cytologic Examination in the Detection of Urothelial Neoplasm.
  • 2010 AccessSurgery
    editor, Henry M. Kuerer.
    "Written by an internationally recognized multidisciplinary team of authors, Kuerer's Breast Surgical Oncology is the first text specifically dedicated to breast surgical oncology. ... Kuerer's examines all clinically relevant knowledge in the field, from the pathology of the breast and clinical management, to follow-up and complications following diagnosis and therapy. The book also focuses on the next wave of molecular studies that represent the future of the discipline."--BOOK JACKET.
  • 2015 Springer
    Chang-Ming Huang, Chao-Hui Zheng, editors.
  • 2009 Springer
    by Bertrand Guillonneau, Inderbir S. Gill, Günter Janetschek, Ingolf A. Tuerk.
  • 2005 Springer
    Jean J.M.C.H. de la Rosette, Inderbir S. Gill, editors.
  • 2008 Springer
    P. Rubin, L.S. Constine, L.B. Marks, P. Okunieff, (eds.).
  • 2009 Springer
    edited by Stewart Goldman, Christopher Turner.
    Part I. Overview of brain tumor survivorship -- Introduction to brain tumor survivorship and historical perspective / Stewart Goldman and Christopher D. Turner -- Late effects of neurosurgery / Arthur J. DiPatri, Martin Pham, and Kenji Muro -- Late effects of CNS radiation therapy / Helen A. Shih, Jay S. Loeffler, and Nancy J. Tarbell -- Late effects of chemotherapy / Sridharan Gururangan -- Late effects of stem cell transplantation in brain tumor survivors / Karina Danner-Koptik, David A. Jacobsohn, and Kimberley J. Dilley -- Effect of cancer treatment on neural stem and progenitor cells / Jörg Dietrich and Santosh Kesari -- The pediatric brain tumor late effects clinic / Kimberly J. Dilley and Barbara Lockart -- Part II. Medical late effects of brain tumor treatment -- Neurological complications in adults / Michelle Monje and Patrick Y. Wen -- Neurological complications in children / Sonia Partap and Paul Graham Fisher -- Strokes among childhood brain tumor survivors / Daniel C. Bowers -- Endocrine late effects: manifestations and treatments / Jason R. Fangusaro and Elizabeth Eaumann Littlejohn -- Ocular consequences and late effects of brain tumor treatments / María E. Echevarría and Joanna L. Weinstein -- Auditory late effects of chemotherapy / Anna K. Meyer and Nancy M. Young -- Reproductive health issues in survivors of childhood and adult brain tumors / Tress Goodwin, B. Elizabeth Delasobera, and Paul Graham Fisher -- Cancer predisposition syndromes / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral -- Secondary neoplasms following treatment for brain tumors / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral.
    Also available: Print – 2009
  • 2010 ClinicalKey
    [edited by] Richard T. Hoppe, Theodore Locke Phillips, Mack Roach, III.
    Section I. Radiation biology and physics -- Section II. Imaging -- Section III. Radiation oncology -- Part 1. Central nervous system -- Part 2. Head and neck tumors -- Part 3. Tumors of the thorax -- Part 4. Gastrointestinal tumors -- Part 5. Urologic tumors -- Part 6. Gynecologic tumors -- Part 7. Pediatric tumors -- Part 8. Cancer of the breast -- Part 9. Adult sarcomas -- Part 10. Lymphomas -- Part 11. Ocular cancer -- Part 12. Skin cancer -- Part 13. Benign disease -- Section IV. Emerging radiation modalities.
    Also available: Print – 2010
  • 2005 Springer
    edited by Lauren E. Abrey, Marc C. Chamberlain, and Herbert H. Engelhard.
    Anatomy and physiology of the leptomeninges and CSF space / Neil Barshes, Alexis Demopoulos and Herbert H. Engelhard -- Leptomeningeal neoplasia: epidemiology, clinical presentation, CSF analysis and diagnostic imaging / Roelien H. Enting -- Leptomeningeal metastases from solid tumors (Meningeal carcinomatosis) / Michiko Kimura Bruno and Jeffrey Raizer -- Leptomeningeal metastases from leukemias and lymphomas / Craig P. Nolan and Lauren E. Abrey -- Leptomeningeal metastasis of primary central nervous system (CNS) neoplasms / Herbert H. Engelhard and Luke A. Corsten -- Leptomeningeal cancer in the pediatric patient / Kathleen A. Neville and Susan M. Blaney -- Neurosurgical interventions for leptomeningeal tumor / Jeffrey P. Greenfield and Mark H. Bilsky -- Current treatment of leptomeningeal metastases: systemic chemotherapy, intrathecal chemotherapy and symptom management / Stacey L. Berg and Marc C. Chamberlain -- Radiation therapy for leptomeningeal cancer / Minesh Mehta and Kristin Bradley -- Animal models of leptomeningeal cancer / Ali Raja and Herbert H. Engelhard -- Improving the outcome of patients with leptomeningeal cancer: new clinical trials and experimental therapies / Kurt Jaeckle.
    Also available: Print – 2005
  • 2003 Wellcome Trust
    edited by D.A. Christie and E.M. Tansey.
  • 2009 Springer Protocols
    edited by Chi Wai Eric So.
    An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia / C.W. So -- Backtracking of leukemic clones to birth / J. Wiemels, M. Kang and M. Greaves -- Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia / Z.J. Konn ... [et al.] -- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research / L. Kearney and S. Colman -- LDI-PCR: identification of known and unknown gene fusions of the human MLL gene / C. Meyer and R. Marschalek -- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences / B.W. Robinson and C.A. Felix -- MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR / V.H. van der Velden and J.J. van Dongen -- Array-based comparative genomic hybridization as a tool for analyzing the leukemia genome / J.C. Strefford and H. Parker -- Application of SNP genotype arrays to determine somatic changes in cancer / M. Gupta and B.D. Young -- Retroviral/Lentiviral transduction and transformation assay / B.B. Zeisig and C.W. So -- Gene expression profiling of leukemia stem cells / A.V. Krivtsov ... [et al.] -- Humanized model to study leukemic stem cells / D. Bonnet -- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction / M. Wunderlich and J.C. Mulloy -- Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells / J.J. Schuringa and H. Schepers -- Identification and characterization of hematopoietic stem and progenitor cell populations in mouse bone marrow by flow cytometry / J. Yeung and A.C. Wai Eric So -- In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development / P. Sroczynska ... [et al.] -- Analysis of the mouse placenta as a hematopoietic stem cell niche / K. Ottersbach and E. Dzierzak -- Identification of protein interaction partners by the yeast two-hybrid system / M.P. Garcia-Cuellar, D. Mederer and R.K. Slany -- Complete array of HOX gene expression by RQ-PCR / G.J. Dickson, T.R. Lappin and A. Thompson -- Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias / M.E. Figueroa, A. Melnick and J.M. Greally -- Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins / T.A. Milne, K. Zhao and J.L. Hess.
  • 2013 Springer
    Abraham Haim, Boris A. Portnov.
    Artificial light and human temporal organization. Artificial light and its physiochemical properties -- Light and dark cycles as a basis of temporal organization -- Biological clock and its entrainment by photoperiod -- Light at night (LAN) exposure and its potential effects on daily rhythms and seasonal disruptions -- Melatonin : "hormone of darkness" and a "Jack of all traits" -- Light pollution, its known health effects and impact on energy conservation. Introduction and spread of artificial illumination : a human history retrospective -- Biological definition of light pollution -- Light-at-night (LAN) as a general stressor -- Effects of light pollution on animal daily rhythms and seaonality : ecological consequences -- Light polluiton and hormone-dependent cancers : a summary of accumulated empirical evidence -- Light pollution and its potential links to breast and prostate cancers. Geographic patterns of breast and prostate cancers (BC&PC) worldwide -- Light pollution and its associations with BC&PC in population-level studies -- Selected methodological issues of LAN-BC&PC reserach -- Dark-less world : what is next? (conclusions and prospects for future research).
  • 2006 Springer
    edited by Angus G. Dalgleish, Burkhard Haefner.
    Inflammation and cancer: the role of the immune response and angiogenesis / Angus G. Dalgleish and Ken O'Byrne -- Chronic inflammation and pathogenesis of GI and pancreatic cancers / Lindsey N. Jackson and B. Mark Evers -- Cytokines, NF-[kappa]B, microenvironment, intestinal inflammation and cancer / Arndt J. Schottelius and Harald Dinter -- Regulation of NF-[kappa]B transcriptional activity / Linda Vermeulen, Wim Vanden Berghe and Guy Haegeman -- The role of immune cells in the tumor microenvironment / Theresa L. Whiteside -- Tumor-microenvironment interactions: the seletcin-selectin ligand axis in tumor-endothelium cross talk / Isaac P. Witz -- CD95L/FasL and trail in tumour surveillance and cancer therapy / Harald Wajant -- Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer / Jessica Berout and Andrei Thomas-Tikhonenko -- Cytokines as mediators and targets for cancer cachexia / Josep M. Argilés, Sílvia Busquets and Francisco J. López-Soriano -- Targeting NF-[kappa]B in anticancer adjunctive chemotherapy / Burkhard Haefner.
    Also available: Print – 2006
  • 2014 Springer
    edited by Antonia Kolokythas.
    The lip is the most common site of malignancy in the head and neck region. Although high cure rates can be achieved by early treatment, a significant percentage of lip cancers demonstrate aggressive behaviour, posing management difficulties. Given the aesthetic and functional significance of the lip, reconstruction post surgery is also extremely important, yet this, too, can be challenging. This textbook is intended as a comprehensive reference that will provide easy-to-follow and well-organized guidance on the management of lip cancer, from diagnosis to treatment and reconstruction. After discussion of anatomy and premalignant conditions, detailed attention is paid to squamous cell carcinoma of the lip. Surgical management is explained, and the roles of radiation therapy and chemotherapy, discussed. Reconstruction techniques following ablative surgery are then described in depth, with reference to defect size and complexity. In addition, the potential complications of treatment and reconstruction are presented, with advice on their management. The closing chapter considers other malignant lesions of the lip. The informative text is complemented by high-quality illustrations and clinical and radiographic material. The contributors all have extensive experience and in-depth knowledge of the topics they address.
  • 2009 Springer
    edited by Jean-François Jeannin.
    Structure and synthesis of lipid A / Shoichi Kusumoto, Masahito Hashimoto and Kazuyoshi Kawahara -- Conformation and supramolecular structure of lipid A / Klaus Brandenburg and Ulrich Seydel -- Interactions between lipid A and serum proteins / Jèorg Andrèa ... [et al.] -- The lipid A receptor / Kiyoshi Takeda -- Lipid A receptor TLR4-mediated signaling pathways / Masahiro Yamamoto and Shizuo Akira -- Lipid A-induced responses in vivo / Néjia Sassi ... [et al.] -- Lipid A-mediated tolerance and cancer therapy / Cheryl E. Rockwell, David C. Morrison and Nilofer Qureshi -- Lipid A in cancer therapies : preclinical results / Daniele Reisser and Jean-François Jeannin -- Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines : clinical results / Christopher W. Cluff -- Antitumoral effects of lipids A : clinical studies / Marc Bardou and Danièle Reisser.
    Also available: Print – 2009
  • 2001 Ovid
    Delia C. Baquiran.
    Also available: Print – 2001
  • 2009 Springer
    edited by M.A. Hayat.
  • 2009 Springer
    Jean-Nicolas Vauthey ... [et al.], editors.
  • 2011 Springer
    edited by Pnina Brodt.
    Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
  • 2013
    investigators, Thomas A. Ratko, Vikrant Vats, Jennifer Brock, B.W. Ruffner, Jr., Naomi Aronson.
    OBJECTIVES: We prepared this report on the comparative effectiveness and harms of lung-directed nonsurgical therapies for non-small-cell lung cancer (NSCLC) in three distinct patient populations: (1) patients with stage I NSCLC who are not surgical candidates (Key Question 1), (2) patients with stage I NSCLC who are deemed operable but decline surgery (Key Question 2), and (3) patients with endoluminal NSCLC causing obstruction (Key Question 3). For stage I NSCLC, the local nonsurgical interventions could include conformal radiotherapy modalities and radiofrequency ablation (RFA). For patients with airway obstruction due to an endoluminal NSCLC, local nonsurgical interventions could include those for the stage I setting, as well as conventional wide-field radiotherapy, brachytherapy, laser and mechanical debridement, endoluminal stents, cryoablation, and photodynamic therapy. Surgical resection of any type is not considered as a comparator for any of the Key Questions. DATA SOURCES: MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry were searched from January 1, 1995, to July 25, 2012. A search of the gray literature included databases with regulatory information, clinical trial registries, abstracts and conference papers, and information from manufacturers. REVIEW METHODS: We sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverse events, and quality of life among our populations of interest. Data were abstracted for each Key Question by a team of reviewers, with independent data verification. Study quality and the risk of bias of randomized controlled trials (RCTs) were assessed using the United States Preventive Services Task Force criteria. The quality and risk of bias of single-arm studies were assessed using the Carey and Boden criteria. The strength of the body of evidence was assessed according to the Agency for Healthcare Research and Quality Methods Guide. RESULTS: In our searches, we identified 4,648 unique titles and screened 1,178 in full text. Of the latter, 55 met the inclusion criteria. Thirty-five studies were relevant to Key Question 1, considering medically inoperable patients with stage I NSCLC; 6 were relevant to Key Question 2, considering medically operable patients with stage I NSCLC who decline surgery; and 17 were relevant to Key Question 3, considering patients with inoperable endoluminal NSCLC causing symptoms of obstruction. Three studies addressed both Key Questions 1 and 2. All studies relevant to Key Questions 1 and 2 were single-arm design, prospective (n=15), retrospective (n=21), or not specified (n=2). Among 17 papers included for Key Question 3, 5 were RCTs, 1 was a nonrandomized comparative study, and 11 were single-arm studies. Because comparative study evidence on RFA and debridement and stenting was unavailable for Key Question 3, we included evidence from two single-arm studies involving stents and one on RFA. All RCTs were of poor quality. Only one comparison was available per study, with no two studies examining the same set of interventions. Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of life. CONCLUSIONS: Evidence on localized nonsurgical therapies for patients with stage I NSCLC who are not surgical candidates or who decline surgery consists only of single-arm studies, with no direct comparisons among interventions. The best evidence for NSCLC patients with endoluminal obstruction consists of poor-quality single RCTs for each comparison; we did not identify evidence that permitted us to draw conclusions based on indirect comparisons. Overall, evidence is insufficient to permit conclusions on the comparative effectiveness of local nonsurgical therapies for inoperable or operable patients with stage I NSCLC or inoperable NSCLC patients with endoluminal tumor causing pulmonary symptoms.
  • 2015 Springer
    Eric Van Cutsem, Thomas J. Vogl, Vranco Orsi, Alberto Sobrero, editors.
    Basics of Regional Tumor therapies: Locoregional Tumor Therapies, Evidence and Future -- Pharmacokinetic of Locoregional Tumor Therapies -- Embolization Materials, Catheter, IA-port systems Indications for locoregional tumor therapies ? Liver: HCC -- Liver Metastases of CRC- Liver Metastases of Neuroendocrine Tumors and CCC -- Liver metastases of other indications: Pancreas Carcinoma -- Melanoma -- Breast Carcinoma. Indications for locoregional tumortherapies ? Lung: Basics -- Primary Lung Tumors -- Lung metastases Thermoablation: Liver -- Lung. Head and Neck.
  • 2003 Springer Protocols
    v. 2 Springer Protocols
    edited by Barbara Driscoll.
    v. 1. Molecular pathology methods and reviews: Characteristic genetic alterations in lung cancer / Wistuba, II and A.F. Gazdar -- Clinical and biological relevance of recently defined categories of pulmonary neoplasia / E. Gabrielson -- Molecular epidemiology of human cancer risk. Gene-environment interactions and p53 mutation spectrum in human lung cancer / K. Vahakangas -- Neuroendocrine phenotype of small cell lung cancer / J.M. Coulson, M. Ocejo-Garcia and P.J. Woll -- Aids-associated pulmonary cancers / K. Katariya and R.J. Thurer-Abrogation of the rb-p16 tumor suppressor pathway in human lung cancer / J. Geradts -- Sensitive detection of hypermethylated p16ink4a alleles in exfoliative tissue material / M. Schuermann and M. Kersting -- Role of receptor tyrosine kinases in lung cancer / G. Maulik, T. Kijima and R. Salgia -- Relationship of egfr signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines / W. Lei, P.P. Koty and M.L. Levitt -- Detection of the transcripts and proteins for the transforming growth factor-beta isoforms and receptors in mouse lung tumorigenesis using in situ hybridization and immunohistochemistry in paraffin-embedded tissue sections / S.B. Jakowlew and J. Mariano -- Alterations in the expression of insulin-like growth factors and their binding proteins in lung cancer / C.M. Coleman and A. Grimberg -- Screening of mutations in the ras family of oncogenes by polymerase chain reaction-based ligase chain reaction / A. Martinez [and others] -- Assays for raf-1 kinase phosphorylation and activity in human small cell lung cancer cells / R.K. Ravi and B.D. Nelkin -- Gamma-glutamylcysteine synthetase in lung cancer. Effect on cell viability / K. Jarvinen, Y. Soini and V.L. Kinnula -- Localization of cyclooxygenase-2 protein expression in lung cancer specimens by immunohistochemical analysis / S.A. Wardlaw and T.H. March -- Non-ri protocols for l-myc allelotyping and deletion mapping of chromosome 1p in primary lung cancers / K. Hiyama, C. Mendoza and E. Hiyama -- Intercellular adhesion molecules (icam-1, vcam-1, and lfa-1) in adenocarcinoma of lung. Technical aspects / A.E. Fraire [and others] -- Muc1 expression in lung cancer / E. Szabo -- Altered surface markers in lung cancer. Lack of cell-surface fas/apo-1 expression in pulmonary adenocarcinoma may allow escape from immune surveillance / Y. Nambu and D.G. Beer -- Prognostic relevance of angiogenic, proliferative, and apoptotic factors in lung carcinomas. A case review / M. Volm and R. Koomagi -- Morphological assessment of apoptosis in human lung cells / L.D. Dwyer-Nield [and others] -- [d-arg6, d-trp7,9, nmephe8]-substance p (6-11) activates jnk and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism / A. MacKinnon and T. Sethi -- Isolation of cells entering different programmed cell death pathways using a discontinuous percoll gradient / P.P. Koty [and others] -- Angiogenesis, metastasis, and lung cancer. An overview / A. Onn and R.S. Herbst -- Matrix metalloproteinase expression in lung cancer / M. Lim and D.M. Jablons -- Vascular endothelial growth factor expression in non-small cell lung cancer / K.J. O'Byrne [and others] -- Regulation of angiostatin mobilization by tumor-derived matrix metalloproteinase-2 / M.A. Moses and M.S. O'Reilly -- In vitro and in vivo assays for the proliferative and vascular permeabilization activities of vascular endothelial growth factor (vegf) and its receptor / S. Yano, R.S. Herbst and S. Sone -- Detection of telomerase activity in lung cancer tissues / K. Hiyama and E. Hiyama -- Analysis of alterations in a base-excision repair gene in lung cancer / N. Bhattacharyya and S. Banerjee -- Induction of lung cancer by passive smoking in an animal model system / H. Witschi -- Metastatic orthotopic mouse models of lung cancer / R.M. Hoffman -- Lung-specific expression of mutant p53 as mouse model for lung cancer / K.M. Tchou-Wong and W.N. Rom -- Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer / D.L. Cheo and E.C. Friedberg -- Nude mouse lung metastases models of osteosarcoma and Ewing's sarcoma for evaluating new therapeutic strategies / S.F. Jia, R.R. Zhou and E.S. Kleinerman -- Tumor-specific metastasis to lung using reporter gene-tagged tumor cells / L.A. Culp [and others] -- Cultures of surgical material from lung cancers. A kinetic approach / B.C. Baguley, E.S. Marshall and T.I. Christmas -- The hollow fiber assay / L.A. Hall [and others]. v. 2. Diagnostic and therapeutic methods and reviews: Molecular and genetic aspects of lung cancer / W.N. Rom and K.M. Tchou-Wong -- Molecular alterations in lung cancer. Impact on prognosis / T. Kijima, G. Maulik and R. Salgia -- Cellular predictive factors of drug resistance in non-small cell lung carcinomas / M. Volm, R. Koomagi and W. Rittgen -- Clinical implications of p53 mutations in lung cancer / B.G. Campling and W.S. el-Deiry -- An epidemiologic and clinicopathologic overview of aids-associated pulmonary Kaposi's sarcoma / D.M. Aboulafia -- Myeloperoxidase promoter region polymorphism and lung cancer risk / X. Wu, M.B. Schabath and M.R. Spitz -- Clinical utility of tumor markers in the management of non-small cell lung cancer / D.E. Niewoehner and J.B. Rubins -- Detection of chromosomal aberrations in lung tissue and peripheral blood lymphocytes using interphase fluorescence in situ hybridization (fish) / R.A. el-Zein and S.Z. Abdel-Rahman -- In situ analysis of telomerase rna gene expression as a marker for tumor progression / W.N. Keith -- A high-throughput methodology for identifying molecular targets overexpressed in lung cancers / T. Wang and S.G. Reed -- Expression profiling of lung cancer based on suppression subtraction hybridization (ssh) / S. Petersen and I. Petersen -- Comparative genomic hybridization of human lung cancer / I. Petersen -- Sensitive assays for detection of lung cancer. Molecular markers in blood samples / M.V. Fournier [and others] -- Fluorescent microsatellite analysis in bronchial lavage as a potential diagnostic tool for lung cancer / J.K. Field and T. Liloglou -- Southern blotting of genomic DNA from lung and its tumors. Application to analysis of allele loss on chromosome 11p15.5 / D.M. Pitterle and G. Bepler -- Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk / X. Wu [and others] -- Comparative multiplex pcr and allele-specific expression analysis in human lung cancer. Tools to facilitate target identification / J. Heighway [and others] -- Detection of k-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-exacct / V.A. Somers and F.B. Thunnissen -- Detection of k-ras and p53 mutations by "mutant-enriched" pcr-rflp / M. Schuermann -- Detection of small cell lung cancer by rt-pcr for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factor / J.M. Coulson [and others] -- Utilization of thyroid transcription factor-1 immunostaining in the diagnosis of lung tumors / N.G. Ordonez -- Molecular biologic substaging of stage i nsclc through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue / M.B. Joshi, T.A. D'Amico and D.H. Harpole, Jr. -- A sensitive immunofluorescence assay for detection of p53 protein in the sputum / Z. Feng, D. Tian and R. Goldman -- Spr1. An early molecular marker for bronchial carcinogenesis / D. Lau [and others] -- Determination of biological parameters on fine-needle aspirates from non-small cell lung cancer / C. Bozzetti [and others] -- Detection and analysis of lung cancer cells from body fluids using a rare event imaging system / S.K. Kraeft, R. Salgia and L.B. Chen -- Reconstruction of geno-phenotypic evolutionary sequences from intracellular patterns of molecular abnormalities in human solid tumors / S.E. Shackney [and others] -- Surgical treatment of lung cancer. Past and present / C.F. Mountain and K.E. Hermes -- Recent advances and dilemmas in the radiotherapeutic management of locally advanced non-small cell lung cancer / B. Movsas -- Photodynamic therapy in lung cancer. A review / D. Ost -- Gene therapy for lung cancer. An introduction / E.B. Haura, E. Sotomayor and S.J. Antonia -- Identifying obstacles to viral gene therapy for lung cancer. Malignant pleural effusions as a paradigm / R.K. Batra, R.M. Bernal and S. Sharma -- Topical gene therapy for pulmonary diseases with pei-DNA aerosol complexes / A. Gautam [and others] -- Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates / F.M. Orson [and others] -- Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer / P.P. Claudio and A. Giordano -- Aerosol gene therapy for metastatic lung cancer using pei-p53 complexes / A. Gautam [and others] -- Clinical development of antisense oligonucleotides as anti-cancer therapeutics / H.X. Chen -- Antisense oligonucleotides targeting ri alpha subunit of protein kinase a. In vitro and in vivo anti-tumor activity and pharmacokinetics / R. Zhang and H. Wang -- Use of antisense oligonucleotides for therapy. Manipulation of apoptosis inhibitors for destruction of lung cancer cells / S.H. Leech, R.A. Olie and U. Zangemeister-Wittke -- Induction of programmed cell death with an antisense bcl-2 oligonucleotide / P.P. Koty, W. Lei and M.L. Levitt -- Tumor vaccination with cytokine-encapsulated microspheres / N.K. Egilmez [and others] -- Adoptive immunotherapy / J.A. Kim and S. Shu -- Intratumoral therapy with cytokine gene-modified dendritic cells in murine lung cancer models / S. Sharma [and others] -- Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer / S. Sharma [and others] -- Chemoprevention of lung cancer / H. Witschi-Assessing the interaction of particulate delivery systems with lung surfactant / T.S. Wiedmann -- Chemopreventive therapeutics. Inhalation therapies for lung cancer and bronchial premalignancy / M. Haigentz, Jr. and R. Perez-Soler.
  • 2010 Springer
    edited by David J. Stewart.
  • 2005 Ovid
    editors, Harvey I. Pass, David, P. Carbone, David H. Johnson ... [et al.].
    Etiology and epidemiology -- Lung cancer biology -- Screening/early detection/prevention -- Pathology and molecular classification -- Clinical presentation, diagnosis, staging, and prognosis -- Surgery -- Radiation therapy -- Chemotherapy -- Multimodality therapy of NSCLC -- Treatment of small cell lung cancer -- Novel therapeutic strategies -- Palliation and special considerations -- Other thoracic tumors.
    Also available: Print – 2005
  • 2015 Springer
    Mieczyslaw Pokorski, editor.
    Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.
    Also available: Print – 2015
  • 2016 Springer
    Aamir Ahmad, Shirish Gadgeel, editors.
    1. Lung Cancer Statistics -- 2. Epidemiology of Lung Cancer -- 3. Lung Cancer In Never Smokers -- 4. Immune Therapy -- 5. Anti-angiogenesis in personalized therapy of lung cancer -- 6. Target therapy in Lung Cancer -- 7. Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: an update -- 8. KRAS-Mutant Lung Cancers in the Era of Targeted Therapy -- 9. Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer -- 10. Chemotherapy Resistance in Lung Cancer -- 11. Current state of metal-based drugs for the efficient therapy of lung cancers and lung metastases.
    Also available: Print – 2016
  • 2016 Springer
    Aamir Ahmad, Shirish M. Gadgeel, editors.
    Lung cancer genomics in the era of accelerated targeted drug development / Priyanga Wijesinghe and Aliccia Bollig-Fischer -- Emerging biomarkers in personalized therapy of lung cancer / Philip T. Cagle, Kirtee Raparia, and Bryce P. Portier -- Epithelial mesenchymal transition in aggressive lung cancers / Vivek Mittal -- The role of cancer stem cells in recurrent and drug-resistant lung cancer / Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip A. Philip -- The microenvironment of lung cancer and therapeutic implications / Vivek Mittal, Tina El Rayes, Navneet Narula, Timothy E. McGraw, Nasser K. Altorki, and Mary Helen Barcellos-Hoff -- Epigenetics in personalized management of lung cancer / Aamir Ahmad -- Next-generation sequencing and applications to the diagnosis and treatment of lung cancer / Kristina M. Kruglyak, Erick Lin, and Frank S. Ong -- Nanomedicine for treatment of lung cancer / Sajid Hussain -- Personalized therapy of small cell lung cancer / Bryan J. Schneider and Gregory P. Kalemkerian -- Personalized radiation therapy (PRT) for lung cancer / Jian-Yue Jin and Feng-Ming (Spring) Kong -- Personalized therapy of non-small cell lung cancers (NSCLC) / Shirish M. Gadgeel.
    Also available: Print – 2016
  • 2013 Springer
    James G. Ravenel, editor.
    While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their.
  • 2009 Springer
    Venkateshwar Keshamouni, Douglas Arenberg, Gregory Kalemkerian, editors.
    Lung Cancer: Overview / Shirish M. Gadgeel and Gregory P. Kalemkerian -- Hallmarks of Metastasis / M. Roshni Ray and David M. Jablons -- Tumor Stem Cells and Metastasis / Jaclyn Y. Hung -- Epithelial-Mesenchymal Transition as a Mechanism of Metastasis / Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni and Aristidis Moustakas -- Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis / Charles Kumar Thodeti and Kaustabh Ghosh -- Immunologic Mechanisms in Lung Carcinogenesis and Metastasis / Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma and Tonya Walser, et al. -- Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis / Douglas A. Arenberg -- Chemokines in Lung Cancer Metastasis / Borna Mehrad, Ellen C. Keeley and Robert M. Strieter -- Molecular Control of Lymphatic Metastasis in Lung Cancer / Mark M. Fuster and Judith A. Varner -- Carcinoma-Associated Fibroblasts in Lung Cancer / Roya Navab, Bizhan Bandarchi and Ming-Sound Tsao -- The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer / Zvi G. Fridlender, M. Cecilia Crisanti and Steven M. Albelda -- Experimental Animal Models for Studying Lung Cancer / Jiang Liu and Michael R. Johnston -- Molecular Imaging in Lung Cancer Metastases / Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross and Alnawaz Rehemtulla -- Biomarker Discovery for Metastatic Disease / Gilbert S. Omenn and James D. Cavalcoli -- Current Clinical Management of Metastatic Lung Cancer / Bryan J. Schneider and Suresh S. Ramalingam -- Site-Directed Therapy for Lung Cancer Metastases / Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens and Malini Venkatram, et al. -- Systems Approach for Understanding Metastasis / Peter J. Woolf, Angel Alvarez and Venkateshwar G. Keshamouni.
  • 2012 CRCnetBASE
    edited by Ayman El-Baz, Jasjit S. Suri.
    "Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology, namely, needle biopsy and bronchoscopy, fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation, Nodule segmentation, Vessels segmentation, Airways segmentation, Lung registration, Detection of lung nodules, Diagnosis of detected lung nodules, Shape and appearance analysis of lung nodules. Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging"--Provided by publisher.
  • 2009 Springer
    edited by Steven A. Stacker and Marc G. Achen.
  • 2013 Springer
    Anas Younes, Bertrand Coiffier, editors.
    Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.
  • 2005 Springer Protocols
    edited by Tim Illidge, Peter W.M. Johnson.
    Also available: Print – 2005
  • 2012 Springer
    Tracy Batchelor, Lisa M. DeAngelis, editors ; foreword by James O. Armitage and Franco Cavalli.
    Pt. 1. Introduction -- pt. 2. Central nervous system lymphomas -- pt. 3. Primary CNS lymphoma -- pt. 4. Variants of CNS lymphoma -- pt. 5. Neurological complications of lymphomas and leukemias -- pt. 6. Neurological complications of therapy for lymphomas and leukemias.
  • 2013 Springer Protocols
    edited by Ralf Küppers.
    Origin and pathogenesis of B cell lymphomas / Marc Seifert, René Scholtysik, and Ralf Küppers -- Flow cytometry for non-Hodgkin and classical Hodgkin lymphoma / David Wu, Brent L. Wood, and Jonathan R. Fromm -- Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells / Ralf Küppers, Markus Schneider, and Martin-Leo Hansmann -- PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by genescan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics / Elke Boone, Brenda Verhaaf, and Anton W. Langerak -- Expression cloning of human B cell immunoglobulins / Hedda Wardemann and Juliane Kofer -- Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR / Menno C. van Zelm, Magdalena A. Berkowska, and Jacques J.M. van Dongen -- Detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies / Martin J.S. Dyer -- Stereotyped B cell receptors in B cell leukemias and lymphomas / Nikos Darzentas and Kostas Stamatopoulos -- Flow cytometric MRD detection in selected mature B-cell malignancies / Sebastian Böttcher, Matthias Ritgen, and Michael Kneba -- MRD Detection in B-cell non-hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR / Christiane Pott [and others] -- Enrichment of methylated DNA by methyl-CpG immunoprecipitation / Miriam Sonnet [and others] -- Gene expression profile analysis of lymphomas / Katia Basso and Ulf Klein -- FISH and FICTION to detect chromosomal aberrations in lymphomas / Maciej Giefing and Reiner Siebert -- Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens / Vu N. Ngo -- Studying microRNAs in lymphoma / Joost Kluiver, Izabella Slezak-Prochazka, and Anke van den Berg -- Molecular methods of virus detection in lymphoma / Ruth F. Jarrett, Alice Gallagher, and Derek Gatherer -- High-throughput RNA sequencing in B-cell lymphomas / Wenming Xiao [and others].
  • 2014 Cambridge
    edited by Robert Marcus, John W. Sweetenham, Michael E. Williams.
    Epidemiology / Eve Roman and Alexandra G. Smith -- Prognostic factors for lymphomas / Guillaume Cartron and Philippe Solal-Celigny -- Imaging / Heok K. Cheow and Ashley S. Shaw -- Clinical trials in lymphoma / Thomas M. Habermann and Matthew Maurer -- Hodgkin lymphoma / Stephanie Sasse and Andreas Engert -- Follicular lymphoma / Kristian Bowles, Daniel Hodson, and Robert Marcus -- MALT and other marginal zone lymphomas / Emanuele Zucca and Francesco Bertoni -- Small lymphocytic lymphoma/chronic lymphocytic leukemia / Peter Hillmen -- Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma / Steven P. Treon and Giampaolo Merlini -- Mantle cell lymphoma / Martin Dreyling and Michael E. Williams -- Burkitt and lymphoblastic lymphoma : clinical therapy and outcome / Nirali N. Shah, Alan S. Wayne, and Wyndham H. Wilson -- Therapy of diffuse large B-cell lymphoma / John W. Sweetenham -- Central nervous system lymphomas / Andres J.M. Ferreri and Lisa M. DeAngelis -- T-cell non-Hodgkin lymphoma / Sheetal M. Kircher [and others] -- Primary cutaneous lymphoma / Sean Whittaker -- Lymphoma in the immunosuppressed / Michele Spina [and others] -- Atypical lymphoproliferative, histiocytic, and dentritic cell disorders / Matthew S. Davids and Jennifer R. Brown.
  • 2010 Springer
    L. Harivardhan Reddy, Patrick Couvreur, editors ; foreword by Rakesh K. Jain.
    Part 1. Classification, Opportunities and Challenges -- Classification of Anticancer Drugs Based on Therapeutic Targets -- Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy -- Part 2. Polymer-Based Anticancer Prodrugs -- HPMA-Anticancer Drug Conjugates -- Poly-l-Glutamic Acid Anti-cancer Drug Conjugates -- Polysaccharide-Based Anticancer Prodrugs -- PEG-Anticancer Drugs -- Poly(ethylene glycol)-Protein, Peptide, and Enzyme Conjugates -- Part 3. Lipid-Based -- Anticancer Prodrugs -- Lipid-Based Anticancer Prodrugs -- Part 4. Antibody-Directed Cancer Therapy -- Antibody-Cytotoxic Compound Conjugates for Oncology -- Immunoconjugate Anticancer Therapeutics -- Antibody-Directed Enzyme Prodrug Therapy (ADEPT) for Cancer -- EGFR-Directed Monoclonal Antibodies -- The Biology of the HER Family and Her2/neu Directed-Antibody Therapy -- Anti-Vascular Endothelial Growth Factor Monoclonal Antibodies -- Monoclonal Antibody Therapy for Hematologic Malignancies -- Part 5. Anticancer Oligonucleotide Therapeutics -- Anticancer Oligonucleotides -- Part 6. Miscellaneous -- New Molecular Therapeutic Interventions: The Case of Breast Cancers.
  • 2005 NAP
    Committee on Shortening the Time Line for New Cancer Treatments, National Cancer Policy Board ; Peter C. Adamson, Susan L. Weiner, Joseph V. Simone, and Hellen Gelband, editors ; Institute of Medicine and National Research Council.
  • 2013 AACR
    American Association for Cancer Research.
  • 2013 ClinicalKey
    Jennifer A. Harvey, David E. March.
    The first question -- Physics facts that will improve your images -- Screening mammography 101 and beyond -- The recalled patient : now what? findings on mammography -- Breast anatomy and physiology : knowing what's normal -- Calcifications made easy -- Management of masses : BI-RADS 2, 3, or 4? -- Multiple circumscribed masses -- Architectural distortion -- Mammographic asymmetries -- Expanding the differential diagnosis : going beyond IDC-NOS screening detection -- Finding cancers in dense tissue -- Measuring and managing breast cancer risk diagnostic exams/management -- The painful and the palpable -- Evaluation of nipple discharge -- The male breast -- Imaging the patient with breast cancer postoperative studies -- The postoperative breast -- Evaluating women with implants interventions -- Breast needle biopsy : tips for challenging cases.
  • 2010 Springer
    William D. Foulkes, Kathleen A. Cooney, editors.
  • 2012 Springer
    Mikhail V. Kiselevsky, editor.
    Morphological and Functional Characteristics of Serous Cavities / Olga V. Lebedinskaya, Irina Zh Shubina, Natalia Yu Anisimova, Alexey N. Kopylov and Mikhail V. Kiselevsky -- Pathogenesis of Malignant Effusions / Irina O. Chikileva, Natalia Yu Anisimova, Irina Zh Shubina and Mikhail V. Kiselevsky -- Diagnosis and Treatment of Malignant Pleural Effusion / Sergi Call, David Sánchez and Ramón Rami-Porta -- Malignant Ascites: Diagnosis and Treatment / Fausto Petrelli and Sandro Barni -- Malignant Pericardial Disease / Caroline Chiles and Girish Shroff -- Adoptive Immunotherapy of Malignant Effusions / Irina Zh Shubina, Konstantin S. Titov, Irina O. Chikileva, Lev V. Demidov and Mikhail V. Kiselevsky -- Hyperthermia and Intracavitary Chemotherapy in Prevention and Treatment of Malignant Effusions / Gianfranco Baronzio, Giammaria Fiorentini, Marco Ballerini, Valter Cassuti and Giorgio Forzenigo, et al.
  • 2011 Springer
    Andrea Tannapfel (editor).
    Mineralogy of Asbestos -- Epidemiology of Mesothelioma and Historical Background -- Imaging of Mesothelioma -- Biopsy Techniques for the Diagnosis of Mesothelioma -- Pathohistological Diagnosis and Differential Diagnosis -- Mesothelioma and Analysis of Tissue Fiber Content -- Surgical Therapy of Mesothelioma -- Chemotherapy and Radiotherapy for Mesothelioma -- Genetics and Molecular Biology of Mesothelioma -- Early Stages of Mesothelioma, Screening and Biomarkers.
  • 2005 Springer
    Harvey I. Pass, Nicholas J. Vogelzang, Michele Carbone, editors.
    Also available: Print – 2005
  • 2015 Springer
    Timothy P. Cripe, Nicholas D. Yeager, editors.
    Signs and symptoms -- Diagnostic Studies of Pediatric Bone Tumors: Pathology and Imaging -- Basic Principles of Biopsy -- The evaluation of lung nodules in pediatric bone tumors -- Fertility Preservation and Reproductive Health in Pediatric Bone Tumor Patients -- Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors -- Radiation Management -- Histologic Response and Biologic Markers -- Surgical Approach: Limb Salvage Versus Amputation -- Rehabilitation following Orthopaedic Surgery in Children with Bone Tumors -- Patient Navigation of the Pediatric Bone Tumor Patient Across the Continuum of Care -- Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care -- Post-therapy surveillance of bone tumors -- Recurrent Bone Tumors -- Novel Therapies on the Horizon -- Survivorship.
  • 2005 Thieme Book
    Uwe Fischer, Friedemann Baum ; with contributions by Laszlo Fuezesi and Dorit von Heyden.
    Adenoma -- Adenoma, tubular -- Adenomyoepithelioma -- Adenosis -- Angiosarcoma -- Arteriosclerosis -- Artifact, cream -- Atheroma -- Burn trauma -- Carcinoma -- Carcinosarcoma -- Cysts -- DCIS -- Fat necrosis -- Fibroadenoma -- Galactography -- Gel bleeding -- Gout -- Gynecomastia -- Hamartoma -- Hematoma -- Insect bite -- Lipoma -- Local relapse -- Lymphadenitis -- Mastitis, focal -- Mastitis, postoperative -- Mastopathy, fibrocystic -- Mucinous carcinoma -- Paget disease -- Papilloma, intraductal -- Papillomatosis, intraductal -- Prosthesis rupture -- Radial scars.
    Also available: Print – 2006
  • 2011 Future Med
    editor, Jaffer A. Ajani.
    Gastroesophageal cancers : providing an update / Jaffer A. Ajani -- Epidemiology and etiology of gastric cancer / Amitesh Roy, David Cunningham & Ian Chau -- Surgery of esophagogastric cancer : standards and challenges / Markus Moehler, Anne Palmqvist, Hauke Lang, Hans-Joachim Meyer & Ines Gockel -- Chemotherapy / Vincenzo Catalano & Francesco Graziano -- Targeted therapies / David H. Ilson & Elizabeth C. Smyth -- Guidelines for managing gastric cancer / Vikas Ghai & Yixing Jiang.
  • 2015 Springer
    Badrinath R. Konety, Sam S. Chang, editors.
    This book provides a single, comprehensive reference source that incorporates the epidemiology, natural history, and the latest genetic and molecular biological findings of bladder cancer. This book discusses the diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer and incorporates the new findings on markers for the diagnosis of bladder cancer. Risk stratified treatment of non-muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline-based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. This book covers the application of chemotherapy for muscle invasive and advanced disease. The evidence-based application of multimodality therapy is highlighted. Gaps in current knowledge and important areas for clinical research are highlighted. Authored by experts in their respective fields, Management of Bladder Cancer: A Comprehensive Text with Clinical Scenarios serves as an easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.
  • 2010 Springer
    Malcolm W.R. Reed, Riccardo A. Audisio, editors.
    1. Background and Epidemiology -- Basic Science of Breast Cancer in Older Patients / Irmgard Irminger-Finger -- Tumor Biology and Pathology / Virginie Durbecq and Denis Larsimont Clinical Epidemiology and the Impact of Co-Morbidity on Survival / Adri C. Voogd, Marieke J. Louwman and Jan Willem W. Coebergh -- 2. Special Considerations in the Management of Older Women -- Comprehensive Geriatric Assessment / Margot A. Gosney -- A Practical Mini-Guide to Comprehensive Geriatric Assessment / Siri Rostoft Kristjansson -- Impact of the Physiological Effects of Aging on the Pharmacokinetics and Pharmacodynamics of Systemic Breast Cancer Treatment / Paul Hamberg, Maja J. A. de Jonge and Caroline M. Seynaeve -- Impact of Hormone Replacement Therapy on Breast Cancer / Toral Gathani and Valerie Beral -- Experiences of a Multidisciplinary Elderly Breast Cancer Clinic: Using the Right Specialists, in the Same Place, with Time / Anne Stotter, Mohammad Tahir, Robert S. Pretorius and Thompson Robinson -- 3. Therapeutics -- Mammographic Breast Screening in Elderly Women / Lynda Wyld -- Primary Endocrine Therapy for the Treatment of Early Breast Cancer in Older Women / Lynda Wyld and Daniel Hind -- Peroperative Radiotherapy / Roberto Orecchia, Giovanni Battista Ivaldi and Maria Cristina Leonardi -- General and Local Anesthetics / Bernadette Th. Veering -- The Surgical Management of Breast Cancer in Elderly Women / Malcolm W. R. Reed, Lynda Wyld and Riccardo A. Audisio -- Breast Reconstruction / Marcus J. D. Wagstaff, Malcolm W. R. Reed and Christopher M. Caddy -- Adjuvant Endocrine Therapy / Laura Biganzoli -- Adjuvant Chemotherapy / Sumanta Kumar Pal, Nilesh Vora and Arti Hurria -- Adjuvant Radiotherapy / Pierre G. M. Scalliet -- Prevention and Treatment of Skeletal Complications / Matthew C. Winter, Helen L. Neville-Webbe and Robert E. Coleman -- Medical Management of Advanced Disease / Hans P. M. W. Wildiers -- The Use of Chemotherapy in Elderly Cancer Patients: Dose Adjusting, Drug Interactions, and Polypharmacy / Lazzaro Repetto and Claudia Di Bartolomeo -- 4. Psychosocial Considerations -- Delayed Presentation of Breast Cancer in Older Women / Lindsay J. L. Forbes and Amanda J. Ramirez -- Patient Decision Making / Martine Extermann -- Culture, Ethnicity, and Race: Persistent Disparities in Older Women with Breast Cancer / Antonella Surbone and Marjorie Kagawa-Singer -- Supportive, Palliative and End-of-Life Care for Older Breast Cancer Patients / Elaine Cachia, Ruth Broadhurst and Sam H. Ahmedzai.
  • 2010 Springer
    Ismail Jatoi, Manfred Kaufmann (eds.).
    Anatomy and Physiology of the Breast -- Congenital and Developmental Abnormalities of the Breast -- Nipple Discharge -- Mastalgia -- Management of Common Lactation and Breastfeeding Problems -- Evaluation of a Breast Mass -- Breast Cancer Epidemiology -- Breast Cancer Screening -- Breast Imaging -- Premalignant and Malignant Breast Pathology -- Lobular Carcinoma in Situ -- Ductal Carcinoma in Situ -- Surgical Considerations in the Management of Primary Invasive Breast Cancer -- Sentinel Node Concept -- Breast Reconstructive Surgery -- The Role of Radiotherapy in Breast Cancer Management -- Adjuvant Systemic Therapy for Breast Cancer: An Overview -- Endocrine Therapy -- Chemotherapeutic Agents -- HER2-Targeted Therapy -- Inflammatory and Locally Advanced Breast Cancer -- Preoperative (Neoadjuvant) Systemic Therapy -- Metastatic Breast Cancer -- Hormone Replacement Therapy: A Critical Review -- Breast Diseases in Males -- Breast Cancer in the Elderly -- Breast Cancer in Younger Women -- Psychological Support for the Breast Cancer Patient -- Management of the Patient with a Genetic Predisposition for Breast Cancer -- Chemoprevention of Breast Cancer -- Design, Implementation, and Interpretation of Clinical Trials -- Structure of Breast Care Center -- Medicolegal Pitfalls in Breast Cancer Diagnosis and Management.
  • v. 1-, 2013- Springer
    v. 2 Springer
    v. 3 Springer
    v. 4 Springer
  • 2012 ScienceDirect
    2012 ClinicalKey
    [edited by] Arash Naeim, David B. Reuben, Patricia A. Ganz.
    Section 1. Screening/prevention -- section 2. Diagnosis/assessment -- section 3. Treatment -- section 4. Supportive care -- section 5. Rehabilitation/survivorship -- section 6. Special issues.
  • 2014 Springer
    Fred Saad, Mario A. Eisenberger, editors.
    This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.
  • 2013 Springer
    edited by Demetris Papamichael, Riccardo A. Audisio.
    The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Management of Colorectal Cancers in Older People focuses on treatment strategies of colorectal cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older colorectal cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research. The third volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical and radiation oncologists, gerontologists, proctologists and other members of the multidisciplinary team involved in the care of elderly colorectal cancer patients.
  • 2013 Springer
    Stuart M. Lichman, Riccardo A. Audisio, editors.
    The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Gynecological Cancers in Older Women focuses on treatment strategies of gynecological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older women, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older gynecological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.The second volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical oncologists, gerontologists, gynecologists and other members of the multidisciplinary team involved in the care of elderly gynecological cancer patients.
  • 2015 Springer
    Ulrich Wedding, Riccardo A. Audisio, editors.
    This book focuses on the management of hematological cancer and provides guidance on the management issues specific to older patients, spanning background and epidemiology, special considerations in the management of older people, therapeutics and psychosocial considerations. Management of Hematological Cancers in Older People aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older hematological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance. Management of Hematological Cancers in Older People will appeal to surgical oncologists, medical oncologists and other members of the multidisciplinary team.
  • 2013 Springer
    Cesare Gridelli, Riccardo A. Audisio, editors.
    This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.
  • 2014 Springer
    Eric Raymond, Sandrine Faivre, Philippe Ruszniewski editors.
    This book pursues a multidisciplinary approach, presenting chapters with updated information on various aspects of treatment for patients with neuroendocrine tumors. Authors have been selected from expert centers in Europe and the United States. The goal of this book is to comprehensively summarize recent data and provide inspiring ideas to optimize the care of patients with neuroendocrine tumors. Neuroendocrine tumors are fascinating multifaceted diseases that can primarily localize in many organs with various presentations. These tumors are rare but their increasing incidence renders likely that physicians caring for cancers may have either already faced or may be certainly exposed to diagnose and/or treat a patient with neuroendocrine tumors. Over the last years, novel therapeutic options have emerged for neuroendocrine tumors, profoundly challenging practices that had previously been the standards for decades. These include - but are not limited to - somatostatin analogues, targeted therapies such as tyrosine kinase and mTOR inhibitors, antiangiogenic compounds, but also peptide-receptor targeted therapy or radioembolization. This changing field has generated novel treatment algorithms to guide medical decisions. To better understand and handle the multidisciplinary approaches that are required for optimizing the care of neuroendocrine tumor patients, physicians are now looking for references from experts and comprehensive reviews summarizing current knowledge on treatments for patients with neuroendocrine tumors.
  • 2015 Springer
    Joseph R. Pisegna, editor.
    This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.
  • 2014 Springer
    Daniel J. Culkin, editor.
    Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches, and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology, and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.
  • 2012 Springer
    Michel Bolla, Hendrik van Poppel, editors.
    Epidemiology of Prostate Cancer in Europe / Ruben G. Cremers and Lambertus A. Kiemeney -- Chemoprevention of Prostate Cancer / Bertrand Tombal -- Individual and Mass Screening / Chris H. Bangma, Pim J. van Leeuwen and Monique J. Roobol -- Anatomo-Pathology / Theodorus H. Van der Kwast -- Biomarkers for Prostate Cancer / Gisele H. J. M. Leyten, Peter F. A. Mulders and Jack A. Schalken -- Diagnosis, Clinical Work Up, TNM Classification, Markers / Jean-Luc Descotes and Anne-Sophie Gauchez -- Active Surveillance for Favorable Risk Prostate Cancer: Background, Patient Selection, Triggers for Intervention, and Outcomes / Laurence Klotz -- Open Radical Prostatectomy / Hein van Poppel and Steven Joniau -- Robot-Assisted Radical Prostatectomy / Stefan Carlsson and Nils Peter Wiklund -- Permanent Prostate Brachytherapy / Jan J. Battermann -- High-Dose-Rate Brachytherapy: Indications, Technique, and Results / Alberto Bossi, Rodolfe Verstraet, Lucie Calmels and Pierre Blanchard -- Intensity Modulated Radiotherapy for Prostate Cancer / Olivier Chapet, Corina Udrescu and Ciprian Enachescu -- Combination of Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced and Localized Prostate Cancer / Michel Bolla and Camille Verry -- Postoperative Irradiation: Immediate or Early Delayed? / Dirk Bottke and Thomas Wiegel -- High-Intensity Focused Ultrasound (HIFU) for Prostate Cancer / Albert Gelet, Sebastien Crouzet, Olivier Rouviere and Jean-Yves Chapelon -- Cryotherapy / Matvey Tsivian and Thomas J. Polascik -- Follow-up After Radical Treatments and Relapse / Nicolas Mottet -- First-Line Hormonal Manipulation of Prostate Cancer / Suresh Venugopal and John Anderson -- Resistance to Chemical Castration: Second-Line Hormonal Treatment / Yohann Loriot, Christophe Massard and Karim Fizazi -- Targeted Therapies and Vaccination / Guru Sonpavde and Cora N. Sternberg -- How to Interpret Results? / Laurence Collette -- Management of Prostate Cancer: EAU Guidelines on Screening, Diagnosis and Treatment / Axel Heidenreich -- Better Patients' Perspective / Louis J. Denis.
  • 2013 Springer
    Eric A. Klein, J. Stephen Jones, editors.
    Epidemiology and risk factors / Ranko Miocinovic -- Twenty years and counting : is PSA still useful in 2010? / Haluk Ozen and Sertac Yazici -- Prostate cancer screening : a review of the evidence with clinical practice implications / Timothy J. Wilt -- Beyond PSA : promising new markers for prostate cancer / Leonard Marks -- Hereditary prostate cancer and genetic risk / Adam C. Reese, Graham Casey, and John S. Witte -- Prostate inflammation and prostate cancer / William G. Nelson ... [et al.] -- Molecular progression of prostate cancer : androgens and estrogens / Stephen A. Boorjian and Donald J. Tindall -- The role of obesity and diet in prostate cancer / Jean-Alfred Thomas II and Stephen J. Freedland -- Prostate cancer risk reduction by chemoprevention / Kenneth G. Nepple, Adam S. Kibel, and Gerald L. Andriole -- Current issues in pathologic evaluation / Sara M. Falzarano, Howard S. Levin, and Cristina Magi-Galluzzi -- Optimum prostate biopsy : techniques and strategies / Osama M. Zaytoun and J. Stephen Jones -- The utility of nomograms in routine clinical practice / Carvell T. Nguyen and Michael W. Kattan -- Active surveillance comes of age / Laurence Klotz -- Focal therapy : prostate hemiablation as the first historical treatment model for focal therapy of early stage prostate cancer / Vladimir Mouraviev and Thomas J. Polascik -- Contemporary external beam radiotherapy / Rahul Tendulkar and Kevin Stephans -- Surgery, brachytherapy, or external beam radiation for low- and intermediate-risk disease? / Jay P. Ciezki and Eric A. Klein -- The role for radical prostatectomy in advanced prostate cancer / R. Jeffrey Karnes and Michael L. Blute -- Radiation therapy in the management of locally advanced prostate cancer / Joseph D. Mancias and Anthony L. Zietman -- Clinical implications of measuring quality-of-life in early stage prostate cancer / Peter Chang, Mehrdad Alemozaffar, and Martin G. Sanda -- Treatment modalities of post-prostatectomy incontinence : a historical perspective as well as current therapy options / Christina Ching and Drogo K. Montague -- Management of biochemical recurrence after localized treatment for prostate cancer / Stephen B. Williams and Toni K. Choueiri -- Management of newly diagnosed metastatic disease / C. Lance Cowey and Thomas E. Hutson -- Pitfalls of androgen deprivation therapy / Alicia K. Morgans and Matthew R. Smith -- Current management of castration-resistant prostate cancer (CRPC) / Jorge A. Garcia and Robert Dreicer -- Beta-emitting radiopharmaceuticals and bone metastasis / Oliver Sartor.
  • 2009 Springer
    editors, Yazid Belkacémi, René-Olivier Mirimanoff, Mahmut Ozsahin.
    Section 1 CNS tumors -- Germinal tumours of the central nervous system in adult patients -- Atypical and malignant meningiomas -- Primary central nervous system lymphoma -- Treatment of Medulloblastoma in adults -- Cerebellar glioblastoma multiforme -- Chordoma and chondrosarcoma of the skull base -- Primary spinal epidural lymphoma -- Section 2 Heads and neck tumors -- Esthesioneuroblastoma -- Extranodal NK/T-cell lymphoma, nasal-type -- Uncomon tumours of the nasopharynx -- Rare malignant tumours of the larynx and hypopharynx -- Primary orbital lymphoma -- Primary MALT lymphoma of the salivary glands -- Section 3 Gastro-intestinal tumors -- Mucosal melanoma of the upper aero-digestive tract -- Gastrointestinal stromal tumours -- Small cell carcinomas of the gastrointestinal tract -- Small cell carcinomas of the gastrointestinal tract -- Anorectal Melanoma -- Uncommon Hepatobiliary Tumours -- Unusual pancreatic tumours -- Section 4 Genitourinary -- Rare tumours of the renal pelvis and ureter -- Rare tumours of the urethra -- Uncommon bladder cancers -- Neuroendocrine small cell carcinoma of the prostate: A brief review of pathology, clinical characteristics and treatment guidelines -- Uncommon tumours of the testis -- Primary Testicular lymphoma -- Human chorionic gonadotropin-producing seminoma -- Section 5 Gynecological -- Rare ovarian cancers -- Extraovarian primary peritoneal carcinoma -- Uterine papillary serous carcinoma -- Uterine sarcomas and rare endometrial carcinomas -- Uterine sarcomas and rare endometrial carcinomas -- Rare tumours of the uterine cervix -- Tumours of the vagina and tumours of the vulva -- Section 6 Breast -- Invasive breast cancer and ductal carcinoma in situ in young women -- Tubular carcinoma of the breast -- Adenoid cystic carcinoma of the breast -- Primary squamous cell carcinoma of the breast -- Primary breast lymphoma -- Phyllodes tumours of the breast -- Primary breast sarcomas -- Angiosarcoma of the breast -- Male breast cancer -- Section 7 Lung and intrathoracic malignancies -- Primary uncommon tumours of the lung: lymphomas, sarcomas and melanomas -- Thymoma and thymic carcinoma -- Large cell neuroendocrine carcinoma of the lung -- Neuroendocrine tumours of the lung -- Pleural mesothelioma -- Bronchioloalveolar carcinoma and adenocarcinoma with bronchioloalveolar carcinoma features: a clinico-pathological spectrum -- Primary adenoid cystic carcinoma of the trachea and bronchus -- Tracheal cancers -- Section 8 Malignancies of the skin -- Unusual cutaneous malignancies: cutaneous adnexal tumours -- Kaposi's sarcoma -- Dermatofibrosarcoma protuberans (DFSP) -- Merkel cell carcinoma: A challenge in cancer management -- Langerhans cell histiocytosis (LCH) -- Section 9 Other malignancies -- Primary bone lymphoma (osteolymphoma) -- Erdheim-Chester disease -- Solitary plasmacytoma -- Neuroendocrine tumours.
  • 2013 Springer
    Murray F. Brennan, Cristina R. Antonescu, Robert G. Maki.
    Management of Soft Tissue Sarcoma addresses the diagnosis and best current management of adult soft tissue sarcomas. Edited by world renonwed experts, this book dileneates and discusses each different sarcoma subtype individually -- source other than Library of Congress.
  • 2002 NLM
    prepared by Mary Conway, Hema Padmanabhan.
  • 2013 Springer
    Nora M. Hansen, editor.
    Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies.
  • 2015 Springer
    K. Alok Pathak, Richard W. Nason, Janice L. Pasieka, editors.
    Molecular risk stratification of well-differentiated thyroid cancer -- The significance of cervical lymph nodes in well-differentiated thyroid cancer -- Management of the central compartment in well-differentiated thyroid carcinoma -- Management of the lateral neck in well-differentiated thyroid cancer -- The management of recurrent/persistent well-differentiated thyroid cancer in the central compartment -- Management of distant metastases in differentiated thyroid cancer -- Risk-adjusted strategies in post-treatment surveillance of well-differentiated thyroid carcinoma -- Medullary thyroid cancer -- Anaplastic thyroid cancer: Current concepts -- External beam radiotherapy for thyroid cancer -- Targeted therapies in thyroid cancer.
  • 2006 Springer
    I. Ross McDougall ; with contribution by Gerald J. Berry.
    Also available: Print – 2006
  • 2013 Springer
    Jean-Pierre Droz, Riccardo A. Audisio, editors.
    The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Urological Cancers in Older People focuses on treatment strategies of urological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older urological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.This first volume in the Management of Cancer in Older People series will be of interest to all surgical oncologists, medical oncologists, gerontologists, urologists and other members of the multidisciplinary team involved in the care of elderly urological cancer patients.
  • 2013 Springer
    Donald R. Taylor, MD, Comprehensive Pain Care, PC, Taylor Research, LLC, Marietta, GA.
    Managing Cancer Breakthrough Pain is a comprehensive review of cancer breakthrough pain (cBTP) and rapid-onset opioids (ROO), the only treatment approved for cBTP episodes. The book was originally commissioned due to the current rapid growth of the ROO market and the epidemic of ROO abuse. This book will review the historical background and definitions of cBTP and ROOs, assessment methods to determine types of cBTP, US- and EU-approved ROOs, case studies (which will provide practical applications of ROO treatment options), ROO abuse and screening methods, and the FDA-mandated TIRF REMS Access program (Transmucosal Immediate Release Fentanyl Risk Evaluation and Mitigation Strategies Access program). Busy healthcare professionals who have a basic understanding of cancer pain but want to learn more about cBTP and ROOs will benefit from this concise guide that will help them quickly understand the complexities of cBTP episodes and ROOs.
  • 2016 Springer
    edited by Hatem A. Azim Jr.
    Overview -- 1.Epidemiology of cancer in pregnancy -- 2.Staging workup in pregnant cancer patients -- 3.General concepts on surgical management of cancer during pregnancy -- 4.Role and consequences of radiotherapy in managing cancer during pregnancy -- 5.Pharmacokinetics of systemic anti-cancer therapies during pregnancy -- 6.Obstetrical care of a pregnant woman with cancer -- 7.Psychological and psychosocial care of a pregnant woman with cancer -- 8.Supportive care during pregnancy -- 10.Neonatal care and long-term consequences of in-utero exposure to systemic anticancer therapy -- Disease-specific chapters -- 11.Managing breast cancer during pregnancy -- 12.Managing melanoma during pregnancy -- 13.Managing cervical cancer during pregnancy -- 14.Managing ovarian tumors during pregnancy -- 14.Managing lymphoma during pregnancy -- 15.Managing leukemia during pregnancy -- 16.Managing thoracic cancers during pregnancy.
  • 2010 Springer
    edited by Michael Kleinberg.
  • 2016 Cambridge
    edited by Ruben A. Mesa, Claire Harrison.
    Initial assessment of the undiagnosed patient who has an erythrocytosis, leucocytosis, or thrombocytosis / Mary Frances McMullin -- Practical approaches to molecular testing and diagnosis of mastocytosis, hypereosinophilia, and MDS/MPN overlap syndromes / Nicholas C.P. Cross, Dimitra Koumaki, Georgia Metzgeroth, and Andreas Reiter -- Incidental splenomegaly : an approach to diagnosis / Craig B. Reeder -- When to do a bone marrow biopsy and how to interpret it in the diagnosis of myeloproliferative neoplams / Hans Michael Kvasnicka -- Accurately assessing risk in your myeloproliferative neoplasm patient / Francisco Cervantes and Arturo Pereira -- Incorporating symptomatic assessment in therapy choice for patients with myeloproliferative neoplasms / Robyn M. Scherber, Holly L. Geyer, and Ruben A. Mesa -- The newly diagnosed patient with essential thrombocythemia / Guido Finazzi -- The newly diagnosed patient with polycythemia vera / Alessandro M. Vannucchi and Paola Guglielmelli -- Longstanding polycythemia vera and essential thrombocythemia : monitoring and management goals / Loula Papageorgiou and Claire Harrison -- Management of myelofibrosis which patients are candidates for JAK inhibitors and how to manage patients on JAK inhibitor treatment / Lorenzo Falchi and Srdan Verstovsek -- Hematopoietic cell transplantation for myelofibrosis : who and when? / Veena Fauble and Vikas Gupta -- Systemic mast cell disease, diagnosis and management / Deepti Radia -- Hypereosinophilia an illustrated approach to diagnosis and management / Jason Gotlib -- Myelodysplastic/myeloproliferative neoplasm overlap syndromes / Aaron T. Gerds, Ramon V. Tiu, and Mikkael A. Sekeres -- Atypical chronic myeloid leukemia and chronic neutrophilic leukemia / Daniel A. Pollyea and Jeffrey T. Schowinsky -- Women and children with myeloproliferative neoplasms : special considerations / Robert Schneidewend and Laura C. Michaelis -- Conception and pregnancy in myeloproliferative neoplasms / Susan Robinson -- Managing acute vascular events in patients with myeloproliferative neoplasms / David A. Garcia and Bethany T. Samuelson -- Challenging thrombotic scenarios in the myeloproliferative neoplasms : splanchnic vein thrombosis and others / Brady L. Stein -- Familial myeloproliferative neoplasms : implications for patients and their families / Sabina Swierczek and Josef Prchal -- Management of acute leukemia following myeloproliferative neoplasms / Raoul Tibes.
  • 2010 Springer
    Eggert Stockfleth, Ted Rosen, Stephen Schumack (eds.).
    Diagnosis of Skin Cancer -- Histopathology of Skin Cancer -- Basal Cell Carcinoma -- Squamous Cell Carcinoma In Situ -- Invasive Squamous Cell Carcinoma of the Skin -- Cutaneous Malignant Melanoma -- Merkel Cell Carcinoma -- Cutaneous Lymphomas -- Kaposi Sarcoma -- Other Skin Cancers. Fibrohistiocytic Skin Cancers and Extramammary Paget's Disease -- Skin Cancer Under Special Circumstances -- Skin Cancer Prevention.
  • 2012
    editor, Dennis A. Casciato ; associate editor, Mary C. Territo.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    edited by Nader Francis, Robin H. Kennedy, Olle Ljungqvist, Monty G. Mythen.
    This textbook explores the latest trends in enhanced recovery from colorectal surgery, covering post-surgical fluid management and more, with examples of enhanced recovery pathways and tips on pain control, feeding, mobilisation and criteria for discharge.
  • 2011 ScienceDirect
    2011 ClinicalKey
    Philip Lanzkowsky.
    Chapter 1. Classification and Diagnosis of Anemia in Children -- Chapter 2. Anemia During the Neonatal Period -- Chapter 3. Iron-Deficiency Anemia -- Chapter 4. Megaloblastic Anemia -- Chapter 5. Hematologic Manifestations of Systemic Illness -- Chapter 6. Bone Marrow Failure -- Chapter 7. Red Cell Membrane and Enzyme Defects -- Chapter 8. Hemoglobinopathies -- Chapter 9. Extracorpuscular Hemolytic Anemia -- Chapter 10. Polycythemia -- Chapter 11. Disorders of White Blood Cells -- Chapter 12. Disorders of Platelets -- Chapter 13. Hemostatic Disorders -- Chapter 14. Thrombotic Disorders -- Chapter 15. Lymphadenopathy and Splenomegaly -- Chapter 16. Lymphoproliferative Disorders, Myelodysplastic Syndromes and Myeloproliferative Disorders -- Chapter 17. Leukemias -- Chapter 18. Histiocytosis Syndromes -- Chapter 19. Hodgkin Lymphoma -- Chapter 20. Non-Hodgkin Lymphoma -- Chapter 21. Central Nervous System Malignancies -- Chapter 22. Neuroblastoma -- Chapter 23. Renal Tumors -- Chapter 24. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas -- Chapter 25. Malignant Bone Tumors -- Chapter 26. Retinoblastoma -- Chapter 27. Germ Cell Tumors -- Chapter 28. Hepatic Tumors -- Chapter 29. Hematopoietic Stem Cell Transplantation -- Chapter 30. Management of Oncologic Emergencies -- Chapter 31. Supportive Care of Patients with Cancer -- Chapter 32. Evaluation, Investigations and Management of Late Effects of Childhood Cancer -- Chapter 33. Psychosocial Aspects of Cancer for Children and their Families.
  • 2011 Springer
    Ian N. Olver, editor.
    Cancer symptoms and side effects of treatment -- Cancer pain -- Cancer-related fatigue -- Palliative care: end-of-life symptoms -- Supportive care in elderly cancer patients -- Supportive care in pediatric oncology -- Quality-of-life assessment: the challenge of incorporating quality-of-life and patient-reported outcomes into investigative trials and clinical practice -- Cardiac toxicities of cancer therapies: challenges for patients and survivors of cancer -- Malignant pericardial effusion and cardiac tamponade (cardiac and pericardial symptoms) -- The vena cava syndrome -- Pulmonary toxicity of therapy -- Management of respiratory symptoms in people with cancer -- Endocrine and metabolic symptoms of cancer and its treatment -- Sexual problems in patients with cancer -- Sterility, infertility, and teratogenicity -- Menopause symptoms -- Preserving cardiac health in the breast cancer patient treated with anthracyclines -- Thrombosis and bleeding in cancer patients -- Lymphedema care -- Infections and cancer -- Cancer cachexia and anorexia -- Xerostomia and dental problems in the head and neck radiation patient -- Dysphagia, reflux, and hiccups -- Nausea and vomiting -- Mucositis (oral and gastrointestinal) -- Diarrhea, constipation, and obstruction in cancer management -- Ascites -- Hepatotoxicity and hepatic dysfunction -- Urological symptoms and side effects of treatment -- Gynecological symptoms -- Central nervous system symptoms: headache, seizures, encephalopathy, and memory impairment -- Neuromuscular disease and spinal cord compression -- Eye symptoms and toxicities of systemic chemotherapy -- Extravasation -- Dermatologic toxicities -- Chemotherapy-induced alopecia: overview and methodology for characterizing hair changes and regrowth -- Rehabilitation in cancer -- Oral health and survivorship: late effects of cancer and cancer therapy -- Survivorship: psychosocial, physical issues, and insomnia -- Spiritual issues in supportive cancer care.
  • 2002 CRCnetBASE
    John Roboz.
  • 2011 Springer
    Domenico Ribatti, Enrico Crivellato.
    Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
  • 2012 Springer
    William C.S. Cho, editor.
    1. Evidence-based Anticancer Materia Medica for Lung Cancer / Constance L.L. Saw, Lita S.J. Chew, and Xiaofeng G. Cai -- 2. Evidence-based Anticancer Materia Medica for Colorectal Cancer / Minsig Choi, Ramzi Mohammad, M. Wasif Saif, and Richard Kim -- 3. An Overview of the Current Development of Phytoremedies for Breast Cancer / Chun-Hung Lin, Wai-Leng Lee, and Lie-Fen Shyur -- 4. Evidence-based Anticancer Kampo Medicine for Gastric Cancer / Koji Tanaka, Takeshi Omori, and Toshiro Nishida -- 5. Evidence-based Anticancer Materia Medica for Hepatocellular Carcinoma / Lei Wan -- 6. Evidence-based Anticancer Materia Medica for Prostate Cancer / Yi-Ren Chen, Pei-Wen Hsiao, Feng-Ming Lin, Guan-James Wu, and Chin-Hsien Tsai -- 7. Evidence-based Anticancer Materia Medica for Cervical Cancer / Tatjana Stanojković, Aleksandra Konić-Ristić, Teodora Janković, Gordana Zdunić, and Katarina Šavikin -- 8. Evidence-based Anticancer Materia Medica for Esophageal Cancer / Taixiang Wu, Minawaer Abudou, and Shou Chen -- 9. Evidence-based Anticancer Materia Medica for Lymphoma / Eran Ben-Arye, Tamar Tadmor, Aaron Polliack, and Elad Schiff -- 10. Evidence-based Anticancer Materia Medica for Bladder Cancer / Dawei Ye, Pingping Gu, Hongyu Zhao, Michelle Chow, Xiaoqing Guo, and Jianyu Rao -- 11. Evidence-based Anticancer Materia Medica for Pancreatic Cancer / Shwu-Huey Liu and M. Wasif Saif -- 12. Evidence-based Anticancer Materia Medica for Leukemia / Min Li-Weber -- 13. Evidence-based Anticancer Materia Medica for Nasopharyngeal Carcinoma / Guangcun Deng, Jihui Yang, and Yujiong Wang -- 14. Evidence-based Anticancer Materia Medica for Brain Tumors / Prabha Balaram and Faizah Harun -- 15. Evidence-based Materia Medica for Cancer Chemoprevention / Sunil Prabhu, Ying Huang, and Jeffrey Wang -- 16. Pharmacokinetics of Anticancer Materia Medica in Humans / Shu-Feng Zhou.
  • 2012 Springer
    György Berencsi, editor.
  • 2011 AccessMedicine
    [edited by] Hagop M. Kantarjian, Robert A. Wolff, Charles A. Koller.
    Part I. Leukemia -- Chapter 1. Acute Lymphoblastic Leukemia -- Chapter 2. Adult Acute Myeloid Leukemia -- Chapter 3. Chronic Lymphocytic Leukemia and Associated Disorders -- Chapter 4. Chronic Myeloid Leukemia -- Chapter 5. Myelodysplastic Syndromes: The MD Anderson Cancer Center Approach -- Chapter 6. Philadelphia Chromosome-Negative Myeloproliferative Neoplasms -- Part II. Lymphoma and Myeloma -- Chapter 7. The Indolent Lymphomas -- Chapter 8. Aggressive and Highly Aggressive B-Cell Lymphomas -- Chapter 9. T-Cell Lymphomas -- Chapter 10. Hodgkin Lymphoma -- Chapter 11. Multiple Myeloma and Other Plasma Cell Dyscrasias -- Part III. Stem Cell Transplantation -- Chapter 12. Allogeneic Transplantation -- Chapter 13. Autologous Stem Cell Transplantation -- Part IV. Lung Cancer -- Chapter 14. Small Cell Carcinoma of the Lungs -- Chapter 15. Non-Small Cell Lung Cancer -- Part V. Head and Neck Cancer -- Chapter 16. Head and Neck Cancer -- Part VI. Gastrointestinal Carcinomas -- Chapter 17. Gastric and Esophageal Cancer -- Chapter 18. Pancreatic Cancer -- Chapter 19. Hepatobiliary Malignancies -- Chapter 20. Small Bowel Cancer and Appendiceal Tumors -- Chapter 21. Colorectal Cancer -- Chapter 22. Anal Cancer -- Chapter 23. Neuroendocrine Tumors -- Part VII. Breast Cancer -- Chapter 24. Early-Stage and Locally Advanced Breast Cancer -- Chapter 25. Metastatic Breast Cancer -- Chapter 26. Inflammatory Breast Cancer -- Chapter 27. Special Situations in Breast Cancer -- Part VIII. Gynecologic Malignancies -- Chapter 28. Ovarian Cancer -- Chapter 29. Tumors of the Uterine Corpus -- Chapter 30. Tumors of the Uterine Cervix -- Chapter 31. Gestational Trophoblastic Tumors -- Part IX. Genitourinary Carcinoma -- Chapter 32. Renal Cell Carcinoma -- Chapter 33. Bladder Cancer -- Chapter 34. Prostate Cancer -- Chapter 35. Penile Cancer -- Chapter 36. Germ Cell Tumors -- Part X. Miscellaneous Tumors -- Chapter 37. Tumors of the Central Nervous System -- Chapter 38. Endocrine Malignancies -- Chapter 39. Malignant Melanoma -- Chapter 40. Soft Tissue and Bone Sarcomas -- Chapter 41. The AIDS-Related Cancers -- Chapter 42. Carcinoma of Unknown Primary -- Part XI. Supportive Care -- Chapter 43. Infection in the Neutropenic Patient -- Chapter 44. Fungal and Viral Infections in Cancer Patients -- Chapter 45. Endocrine and Metabolic Complications of Cancer Therapy -- Chapter 46. Oncologic Emergencies -- Part XII. Palliative Care and Symptom Management -- Chapter 47. Defining Palliative Care in Oncology -- Chapter 48. Pain Management and Symptom Control -- Part XIII. Long-Term Survival -- Chapter 49. Pediatric Long-Term Follow-Up -- Chapter 50. Adult Long-Term Follow-Up -- Chapter 51. Rehabilitation.
  • 2012 Ovid
    editors, Barry W. Feig, C. Denise Ching.
    "The current edition of The Handbook provides an overview of current care of patients with cancer diagnoses commonly evaluated and treated by surgical oncologists, and in doing so continues to align such care with the underlying philosophy of the Department of Surgical Oncology at M.D. Anderson: multidisciplinary, cooperative care is the ideal way to manage patients with cancer. Such care begins with an understanding of the underlying tumor biology and natural history of the disease and includes technical excellence in the delivery of indicated surgical treatment. It also demands integration of essential information from the available literature on currently preferred treatment modalities, and emphasizes appropriate inclusion of adjunctive specialty care, including medical oncology, radiation oncology, interventional radiology, palliative care, pain management, physical therapy, nutritional support, social services and nursing"--Provided by publisher.
  • 2006 Ovid
    editors, Barry W. Feig, David H. Berger, George M. Fuhrman.
    1. Noninvasive Breast Cancer / Robert H. I. Andtbacka ... [et al.] -- 2. Invasive Breast Cancer / Jonathan S. Zager ... [et al.] -- 3. Melanoma / Timothy M. Pawlik and Jeffrey E. Gershenwald -- 4. Nonmelanoma Skin Cancer / Nestor F. Esnaola and Keith M. Heaton -- 5. Soft Tissue and Bone Sarcoma / Keith A. Delman and Janice N. Cormier -- 6. Cancer in the Head and Neck / Kenneth A. Newkirk and F. Christopher Holsinger -- 7. Thoracic Malignancies / Shanda H. Blackmon and Ara A. Vaporciyan -- 8. Esophageal Carcinoma / Alexander A. Parikh, Ara A. Vaporciyan, and Wayne L. Hofstetter -- 9. Gastric Cancer / Waddah B. Al-Refaie and Paul F. Mansfield -- 10. Small-Bowel Malignancies and Carcinoid Tumors / Keith D. Amos and Rosa F. Hwang -- 11. Cancer of the Colon, Rectum, and Anus / George J. Chang and Barry W. Feig -- 12. Hepatobiliary Cancers / Eugene A. Choi, Steven E. Rodgers, Syed A. Ahmad, and Eddie K. Abdalla -- 13. Pancreatic Adenocarcinoma / Rosa F. Hwang ... [et al.] -- 14. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia / Jeffrey T. Lenert ... [et al.] -- 15. Adrenal Tumors / Ricardo J. Gonzalez and Jeffrey E. Lee -- 16. Carcinoma of the Thyroid and Parathyroid Glands / Keith D. Amos, Mouhammed A. Habra, and Nancy D. Perrier -- 17. Hematologic Malignancies and Splenic Tumors / Wayne A. I. Frederick ... [et al.] -- 18. Cancer of Unknown Primary Site / Gauri R. Varadhachary -- 19. Genitourinary Cancer / Christopher G. Wood and Colin P.N. Dinney -- 20. Gynecologic Cancers / Brian M. Slomovitz, Pamela T. Soliman, Judith K. Wolf -- 21. Oncologic Emergencies / Jeffrey D. Wayne and Richard J. Bold -- 22. Biologic Cancer Therapy / Daniel Albo, Thomas N. Wang, and George P. Tuszynski -- 23. Pharmacotherapy of Cancer / Judy L. Chase and Chad M. Barnett -- 24. Reconstructive Surgery in the Cancer Patient / Jules A. Feledy, Jr. Matthew M. Hanasono, and Geoffrey L. Robb -- Index.
  • 2013
    prepared for California HealthCare Foundation by Dartmouth Atlas Project and Lown Institute ; author, Shannon Brownlee.
  • 2010 Springer
    edited by Domenico Coppola.
    1. Cytokines and Stressors: Implications for Cancer Immunotherapy -- 2. The Role of Oncogene Activation in Tumor Progression -- 3. Carcinogenic Effects of Ionising Radiation -- 4. Chemical Carcinogenesis Role of Chloroform Further Studies -- 5. Use of Organ Explant and Cell Culture in Cancer Research -- 6. Chromosomal Abnormalities in Selected Hematopoietic Malignancies Detected by Conventional and Molecular Cytogenetics: Diagnostic and Prognostic Significance -- 7. Mechanisms of Cancer Growth and Progression in Lymphoma -- 8. Pediatric Cancer Mechanisms of Cancer Growth and Progression -- 9. Carcinogenetic Pathway of Malignant Melanoma -- 10. Ewing Sarcoma: Molecular Characterization and Potential Molecular Therapeutic Targets -- 11. Molecular Mechanisms of Central Nervous System Metastasis -- 12. Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma -- 13. Postmenopausal Hormone Replacement Therapy and Breast Cancer Clinicopathologic Associations and Molecular Mechanisms -- 14. Carcinogenesis of Lung Cancer -- 15. Genesis of Barretts Neoplasia: Current Concepts -- 16. Genesis of Pancreatic Ductal Neoplasia -- 17. Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms -- 18. Mechanisms of Carcinogenesis in Colorectal Cancer -- 19. Carcinogenetic Pathway of Superficial Low-Grade Urothelial Carcinoma -- 20. Carcinogenetic Pathway of Urothelial Carcinoma -- 21. Mechanisms of Carcinogenesis in Prostate Cancer -- 22. HPV in Cervical Carcinoma -- Index.
  • 2015 Springer
    Sven Otto, editor.
    Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs. This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.
  • 2015 Springer
    Friedhelm Raue, editor.
  • 2014 Springer
    Mai P. Hoang, Martin C. Mihm Jr., editors.
    Melanocytic Lesions: A Case Based Approachprovides a concise yet comprehensive guidelineon how to diagnose common as well as problematic and challenging melanocytic lesions.In the first 11 chapters, each entityis illustrated by an actual case; followed by discussion of how the diagnosis is reached, of the histologic differential diagnoses, and of diagnostic pitfalls; and ends with bulleted teaching points.Pertinent and up to date referencesare included at the end of each chapter. The latter chapterscover current microstaging and classification of melanoma, ancillary techniques including immunohistochemistry as well as available molecular assays and molecular targeted therapy. Melanocytic Lesions: A Case Based Approach serves as a useful resource for pathologists, dermatologists and researchers dealing with melanocytic lesions.
  • 2016 Springer
    Howard L. Kaufman, Janice M. Mehnert, editors.
    Heterogeneity in Melanoma -- Melanoma Epidemiology and Prevention -- Methods Of Melanoma Detection -- Melanoma: Clinical Presentations -- Principles Of Melanoma Stagin -- Surgical Management of Melanoma -- Adjuvant Therapy of Melanoma -- Chemotherapy for Melanoma -- Checkpoint Blockade for the Treatment of Advanced Melanoma -- Targeted Therapy for Melanoma -- Treatment of Melanoma CNS Metastases -- Treatment of Melanoma CNS Metastases -- Mucosal Melanoma: Epidemiology, Biology and Treatment -- Acral Lentiginous Melanoma -- Pediatric Melanoma and Atypical Melanocytic Neoplasms -- Novel Treatments in Development for Melanoma.
    Also available: Print – 2016
  • 2015
    National Collaborating Centre for Cancer ; commissioned by the National Institute for Health and Care Excellence.
  • 2011 Springer
    Anja Bosserhoff (editor).
    The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.
  • 2010 ClinicalKey
    [edited by] M. Necmettin Pamir, Peter M. Black, Rudolf Fahlbusch.
    "Meningiomas, by M. Necmettin Pamir, MD, Peter M. Black, MD, PhD, and Rudolf Fahlbusch, MD, presents current and comprehensive guidance on this most common, yet clinically challenging type of brain tumor. Written and edited by the world's most prominent brain tumor neurosurgeons, it helps you to not only determine the type and location of the tumor, but also the most ideal surgical approach to provide your patients with the best outcomes. An extensive collection of surgical photographs covers unique and original cases, while discussions of pre-surgical techniques and approaches emphasize decision making with the help of all imaging modalities and analysis of symptoms and patient history. Expert Consult functionality enhances your reference power with convenient online access to the complete text and illustrations from the book, along with videos that depict surgical techniques in real time."--Publisher's website.
  • 2013 Springer
    Murad Alam, Jeremy S. Bordeaux, Siegrid S. Yu, editors.
    Part I: Basic Science and Epidemiology -- Basic Science of the Merkel Cell -- Epidemiology and Genetics (Including High Risk Patients, Polyomavirus, Prognostic Factors) -- Part II: Diagnosis -- Clinical Diagnosis -- Staging -- Histopathologic Diagnosis -- Part III: Therapy -- Local Excision (Primary, Recurrent Disease) -- Lymph Node Procedures of the Head and Neck -- Lymph Node Procedures of the Trunk and Extremities -- Radiation Therapy (Primary and Recurrent Disease) -- Chemotherapy (Primary and Recurrent Disease) -- Treatment Algorithm -- Part IV: Expert Opinions and Future Directions -- Case Study A: Multiply Recurrent Merkel Cell Carcinoma -- Case Study B: Radiation Monotherapy for Extensive Local and In-Transit Merkel Cell Carcinoma -- Case Study C: Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver -- Case Study D: Evaluation of Multiple Merkel Cell Carcinomas in a Single Patient -- Case Study E: Multidisciplinary Management of Merkel Cell Carcinoma -- Track and Attack: Emerging Prognostic and Therapeutic Approaches.
  • 2016 Springer
    Piotr Dziegiel, Bartosz Pula, Christopher Kobierzycki, Mariusz Stasiolek, Marzenna Podhorska-Okolow.
    Introduction -- Metallothioneins : structure and functions -- Metallothionein-3 -- The role of metallothioneins in carcinogenesis -- Metallothioneins and immune function.
  • 2007 Springer
    edited by Robert E. Mansel, Oystein Fodstad, and Wen G. Jiang.
  • 2010 Springer
    edited by Nicole Beauchemin, Jacques Huot.
    1. The metastatic process: an overview -- 2. Physiopathology of colorectal metastasis -- 3. The genetics of colorectal cancer -- 4. Epigenetics of colorectal cancer -- 5. Cancer-initiating cells in colorectal cancer -- 6. Epithelial-mesenchymal transition in colorectal cancer -- 7. Cell adhesion molecules in colon cancer metastasis -- 8. Epithelial cell signalling in colorectal cancer metastasis -- 9. Angiogenesis and lymphangiogenesis in colon cancer metastasis -- 10. Role of the host inflammaory response in colon carcinoma initiation, progression, and liver metastasis -- 11. Molecular prognostic markers in colon cancer -- 12. The sentinel lymph node and staging of colorectal cancer -- 13. Treatment of colorectal cancer -- 14. Diagnosis and treatment of rectal cancer -- 15. Future directions -- Index.
  • 2007 Springer
    edited by Richard J. Ablin and Malcolm D. Mason.
  • v.1-2, 2012-2014 Springer Protocols
    v.2 (2014) Springer Protocols
    edited by Miriam Dwek, Susan A. Brooks, Udo Schumacher.
  • 2016 Springer
    R. Lor Randall, editor.
    Part One: The Problem -- Bone Metastases: Epidemiology and Societal Effect -- Part Two: Biology of Metastases and Tissue of Origin Considerations -- Pathobiology of Osteolytic and Osteoblastic Bone Metastases -- Biology of Bone Cancer Pain -- Breast Cancer Bone Metastases -- Prostate Cancer Bone Metastasis -- Lung -- Kidney Metastatic Bone Disease -- Thyroid -- Myeloma -- Part Three: Work-Up for Patients with Suspected Metastatic Bone Disease -- Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone -- Biopsy Considerations -- Part Four: Medical Therapy -- Bisphosphonates, Denosumab and Anabolic Agents in the Treatment of Metastatic Bone Disease -- Biotargeting in Metastatic Bone Disease -- Part Five: Supportive Oncology -- Psychosocial Considerations for Patients with Metastatic Bone Disease -- Pain Management in Metastatic Bone Disease -- When is Hospice Appropriate? The Role for Hospice in Palliating Patients with Bone Metastases -- Part Six: Radiation Oncology -- Current and Emerging Modalities -- Part Seven: Interventional Oncology -- Ablation and Cementation Technologies -- Part Eight: Principles of Orthopaedic Surgical Oncology -- Issues Facing the Established Metastatic Bone Disease Patient, Timing/Indications for Surgery -- Questions to Ask Your Medical Oncology Colleagues -- Consideration of the Temporal Relationship between Surgery and Radiation Therapy -- Role of Surgery in Oligometastatic Disease -- Part Nine: Specific Anatomic Considerations for Surgery -- Metastatic Bone Disease: Pelvis -- Metastatic Bone Disease: Femur -- Metastatic Bone Disease: Femur: Tibia -- Metastatic Bone Disease: Foot -- Metastatic Bone Disease: Femur: Humerus, Scapula -- Metastatic Bone Disease: Forearm, Hand -- Metastatic Bone Disease: Spine -- Part Ten: Emerging Surgical Technologies -- Intraoperative Imaging and Navigation -- Part Eleven: Putting It All Together -- Integrative Approach with the Patient in Mind: A Glance Forward.
  • 2010 ClinicalKey
    edited by Jeffrey K. Aronson.
    Drugs Used in Cancer Chemotherpy -- Corticosteroids and Prostaglandins -- Cytokines and Cytokine Modulators Interferons -- Monoclonal Antibodies -- Immune Modulators.
  • 2013 Springer
    Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
    Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • 2006 Springer
    edited by Simone Mocellin.
    Manufacturing of microarrays -- Technological platforms for microarray gene expression profiling -- Principles of gene microarray data analysis -- Gaining weights ... and feeling good about it! -- Complementary techniques -- Microarrays for cancer diagnosis and classification -- Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy -- Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs -- SNP and mutation analysis -- Cancer development and progression -- Gene expression profiling in malignant lymphomas -- Tumor immunology.
    Also available: Print – 2006
  • 2010
    Christopher Michael Earhart.
    Nanoscience and nanotechnology have been applied in recent years to cancer research, with the goal of bringing about a revolutionary change in the ways in which cancer is diagnosed and treated. Magnetic nanotechnologies, in particular, have shown significant potential in several areas, such as imaging, therapeutics, early detection, and point-of-care therapy monitoring. Most applications of magnetic nanotechnology in cancer research involve the use of nanoscale magnetic carriers. Depending on the properties of the particular carrier and the manner in which they are employed, magnetic carriers can act as MRI contrast enhancing agents, drug delivery vehicles, bio-labels for detection with magnetic biosensors, or selection agents in immunomagnetic separation platforms. The small sizes (10-100 nm), functional surface chemistries, and controllable magnetic responses of nanoscale magnetic carriers allows for interaction with and control of biological entities in both novel and powerful ways. The focus of this thesis is on a specific application of magnetic carriers -- magnetic separation of biomolecules and rare cells. After an introduction and an overview of magnetic separation principles are given in Chapters 1 and 2, Chapters 3-6 discuss the design, fabrication, and use of a novel magnetic separation device, the magnetic sifter. The magnetic sifter is a microfabricated, 7 x 7 mm planar die containing a dense array of pores (~200-5000/mm^2) in a magnetically soft membrane. When magnetized by an external field, the sifter pores generate large magnetic field gradients (~10^6 T/m) near the pore edges, which can capture nanoscale magnetic carriers with high efficiency and throughput. The gradients can be turned off by removing the external field, and the magnetic carriers can be released. The magnetic sifter is a microfluidic device, in the sense that it contains microfabricated, micron-scale pores which generate large field gradients. It is also a macrofluidic device, in that high volume throughput is achieved by parallel flow through the dense array of pores. Magnetic modeling of the magnetic sifter and a method for its fabrication are presented in Chapters 3 and 4. When paired with magnetic carriers functionalized with recognition moieties, the magnetic sifter can be used in both protein and cell enrichment schemes. The focus of Chapter 5 is on using the magnetic sifter to capture individual magnetic nanoparticles. The intended application is for enrichment of cancer protein markers prior to detection with a magnetic spin-valve biosensor. High capture efficiencies (80-100%) of magnetic nanoparticles have been achieved for a single pass through the magnetic sifter. Magnetic nanoparticles can also be released from the magnetic sifter with nearly 100% efficiency. The focus of Chapter 6 is the use of the magnetic sifter for rare cell enrichment, for applications in enumeration and enrichment of circulating tumor cells. It is shown that the magnetic sifter can capture tumor cells from whole blood with high efficiency and throughput (~60% at 5 ml/hr). Furthermore, with its planar structure and presentation of captured cells, the magnetic sifter doubles as a cell imaging platform, allowing for identification and quantification with optical microscopy. In addition to its high capture efficiency and gentle release of captured cells, the small size and scalable fabrication of the magnetic sifter are attractive for applications in point-of-care cancer diagnostics for early detection and monitoring of metastatic disease. In Chapter 7, a method for high-throughput fabrication of novel magnetic carriers, synthetic antiferromagnetic (SAF) nanoparticles is presented. The method has enabled production of large quantities of SAF nanoparticles, which have desirable properties for applications in magnetic separation. The capture and release behavior of SAF nanoparticles with the magnetic sifter has been demonstrated. High capture efficiencies are achieved at flow rates 10-20x higher than what was previously possible with commercially available magnetic carriers. Both the magnetic sifter and physically fabricated SAF nanoparticles offer unique advantages over traditional technologies. They are each, in their own right, promising new technologies for applications in cancer detection and therapy monitoring.
  • 2011 Springer Protocols
    edited by Wei Wu.
    MicroRNA Biogenesis and Cancer / Julia Winter, Sven Diederichs -- Computational Identification of miRNAs Involved in Cancer / Anastasis Oulas, Nestoras Karathanasis, Panayiota Poirazi -- The Principles of MiRNA-Masking Antisense Oligonucleotides Technology / Zhiguo Wang -- The Concept of Multiple-Target Anti-miRNA Antisense Oligonucleotide Technology / Zhiguo Wang -- Modulation of MicroRNAs for Potential Cancer Therapeutics / Wei Wu -- Detection of MicroRNAs in Cultured Cells and Paraffin-Embedded Tissue Specimens by In Situ Hybridization / Ashim Gupta, Yin-Yuan Mo -- MicroRNA Northern Blotting, Precursor Cloning, and Ago2-Improved RNA Interference / Julia Winter, Sven Diederichs -- miRNA Profiling on High-Throughput OpenArray System / Elena V. Grigorenko, Elen Ortenberg, James Hurley, Andrew Bond, Kevin Munnelly -- Silicon Nanowire Biosensor for Ultrasensitive and Label-Free Direct Detection of miRNAs / Guo-Jun Zhang -- High-Throughput and Reliable Protocols for Animal MicroRNA Library Cloning / Caide Xiao -- MicroRNA Regulation of Growth Factor Receptor Signaling in Human Cancer Cells / Keith M. Giles, Andrew Barker, Priscilla M. Zhang, Michael R. Epis, Peter J. Leedman -- Epigenetic Regulation of MicroRNA Expression in Cancer / Hani Choudhry, James W. Catto -- In Vitro Functional Study of miR-126 in Leukemia / Zejuan Li, Jianjun Chen -- Prediction of the Biological Effect of Polymorphisms Within MicroRNA Binding Sites / Debora Landi, Roberto Barale, Federica Gemignani, Stefano Landi -- The Guideline of the Design and Validation of MiRNA Mimics / Zhiguo Wang -- Analysis of Targets and Functions Coregulated by MicroRNAs / Shu-Jen Chen, Hua-Chien Chen -- Utilization of SSCprofiler to Predict a New miRNA Gene / Anastasis Oulas, Panayiota Poirazi -- MicroRNA Profiling Using Fluorescence-Labeled Beads: Data Acquisition and Processing / Thomas Streichert, Benjamin Otto, Ulrich Lehmann.
  • 2015 Springer
    Gaetano Santulli, editor.
    microRNAs in the malignant transformation process / Anne E. Sarver, Lihua Li, Reena V. Kartha, Subbaya Subramanian -- microRNA and chronic lymphocytic leukemia / Dana Elena Giza, George A. Calin -- microRNA in malignant lymphoma / Hiroyuki Tagawa -- MicroRNAs and gastrointestinal stromal tumor / Pinar Akçakaya, Weng-Onn Lui -- Insights into the role of microRNAs in pancreatic cancer pathogenesis: potential for diagnosis, prognosis, and therapy / Mohammad Aslam Khan [and others] -- microRNAs and colorectal cancer / Anna Lena Ress, Samantha Perakis, Martin Pichler -- microRNAs and prostate cancer / Sajni Josson, Leland W. K. Chung, Murali Gururajan -- microRNA and ovarian cancer / Ream Langhe -- microRNA and lung cancer / Valerio Del Vescovo, Michela A. Denti -- microRNAs and soft tissue sarcomas / Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Toshifumi Ozaki -- microRNA and bone cancer / Mary Nugent.
    Also available: Print – 2015
  • 2013 Springer
    Suresh Alahari, editor.
    The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
  • 2010 CRCnetBASE
    edited by Yuriy Gusev.
    Measurement and interpretation of microRNA expression profiles / Bo Curry and Robert Ach -- MicroRNA expression analysis by LNA enhanced microarrays / Rolf Sokilde ... [et al.] -- Analysis and QC for real-time OPCR arrays of human microRNAs / Dirk P. Ditmer ... [et al.] -- Massively parallel microRNA profiling in the haematologic malignancies / Ryan D. Morin ... [et al.] -- Who dunit? microRNAs involved in prostate cancer / Chang Hee Kim -- Intronic microRNA : creation, evolution and regulation / Sailen Barik and Titus Barik -- miRome architechture and genomic instability / Konrad Huppi ... [et al.] -- Interconnection of microRNA and transcription factor-mediated regulatory networks / Yiming Zhou -- Analysis of microRNA profiling data with systems biology tools / Yuriy Gusev ... [et al.] -- Mathematical and computational modeling of post-transriptional gene regulation by microRNAs / Raya Khanin and Desmond J. Higham.
  • 2011 Springer
    William C.S. Cho, editor.
    1 -- MicroRNAs in Cancer (An Overview) -- 2. The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis -- 3. MicroRNAs in Breast Cancer -- 4. MicroRNAs in Colorectal Cancer -- 5. MicroRNAs in Gastric Cancer -- 6. MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets?- 7. MicroRNAs in Hepatocellular Carcinoma -- 8. MicroRNAs in Cervical Carcinoma -- 9. MicroRNAs in Esophageal Cancer -- 10. MicroRNAs in Bladder Cancer -- 11. MicroRNAs in Lymphoma -- 12. MicroRNAs in Leukemia -- 13. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools -- 14. MicroRNAs in Epithelial Ovarian Cancer -- 15. MicroRNAs in Brain Tumors -- 16. MicroRNAs and Cancer Stem Cells -- 17. MicroRNAs in Cancer Invasion and Metastasis -- 18. MicroRNAs in Predicting Radiotherapy and Chemotherapy Response -- 19. Role of MicroRNAs in Anti-cancer Drug Resistance -- 20. MicroRNAs and Cancer Metabolism -- 21. MicroRNAs as Blood-based Biomarkers of Cancer -- 22. RNAi-based Approaches to the Treatment of Brain Tumors.
  • 2016 Springer
    Michael Sand.
  • 2015 Springer
    edited by Ping Liang, Xiao-ling Yu, Jie Yu.
    Microwave ablation is a simple, affordable, and highly precise technique. After its successful application in treating liver tumors, it is now widely used to combat renal tumors, adrenal tumors, thyroid nodes, uterine fibroids and other solid tumors. This book presents 40 successful cases of treating these diseases. A series of picture before treatment, after treatment and from different angles is provided for each kind of tumor treatment. In each chapter, step by step operative techniques and illustrations are included. This book also examines CT, NMR and ultrasonography to evaluate the effect of microwave ablation. Editor Ping Liang, is the Director and Professor at Dept. of Interventional Ultrasound, General Hospital of PLA, Beijing, China. Editor Xiaoling Yu is Professor and Chief physician, Editor Jie Yu is Associate Chief physician at the same department.
  • 2012 Springer
    Michail Ignatiadis, Christos Sotiriou, Klaus Pantel, editors.
    Part 1. Introduction -- Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer: Open Questions for Research / Michail Ignatiadis, Christos Sotiriou and Klaus Pantel -- Part 2. Minimal residual disease and breast cancer metastasis -- Self-Seeding in Cancer / Elizabeth Comen and Larry Norton -- Microenvironments Dictating Tumor Cell Dormancy / Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso -- Part 3. Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization -- Immunomagnetic Separation Technologies / Astrid E. L. M. Hoeppener, Joost F. Swennenhuis and Leon W. M. M. Terstappen -- Microfluidic Technologies / Ali Asgar. S. Bhagat and Chwee Teck Lim -- EPISPOT Assay: Detection of Viable DTCs/CTCs in Solid Tumor Patients / Catherine Alix-Panabières -- Advances in Optical Technologies for Rare Cell Detection and Characterization / Lou Dietz and Richard Bruce -- Size-Based Enrichment Technologies for CTC Detection and Characterization / Anthony Williams, Marija Balic, Ram Datar and Richard Cote -- Emerging Technologies for CTC Detection Based on Depletion of Normal Cells / Maryam Lustberg, Kris R. Jatana, Maciej Zborowski and Jeffrey J. Chalmers -- Molecular Assays for the Detection and Characterization of CTCs / Evi S. Lianidou and Athina Markou -- Multiplex Molecular Analysis of CTCs / Anieta M. Sieuwerts and Stefanie S. Jeffrey -- Part 4. Other blood-based biomarkers / Circulating DNA and Next-Generation Sequencing -- Susanna Cooke and Peter Campbell -- Circulating MicroRNAs as Noninvasive Biomarkers in Breast Cancer / Maria Angelica Cortez, James William Welsh and George Adrian Calin -- Circulating Endothelial Cells and Circulating Endothelial Progenitors / Patrizia Mancuso, Angelica Calleri and Francesco Bertolini -- Part 5. Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in breast cancer clinical research and practice -- DTCs in Breast Cancer: Clinical Research and Practice / W. Janni, Brigitte Rack, N. Kasprowicz, C. Scholz and P. Hepp -- CTCs in Primary Breast Cancer (I) / Brigitte Rack, Ulrich Andergassen, Wolfgang Janni and Julia Neugebauer -- CTCs in Primary Breast Cancer (II) / E. Saloustros and D. Mavroudis -- CTCs in Metastatic Breast Cancer / Antonio Giordano and Massimo Cristofanilli -- HER2-Positive DTCs/CTCs in Breast Cancer / Andreas D. Hartkopf, Malgorzata Banys and Tanja Fehm -- DTCs/CTCs in Breast Cancer: Five Decades Later / Susan Alsamarai, Maysa M. Abu-Khalaf and Lyndsay N. Harris -- Part 6. Drug and circulating tumor cell co-development -- Challenges in Drug and Biomarker Co-Development / Sheila E. Taube and Tracy Lively -- Challenges and Opportunities in the Use of CTCs for Companion Diagnostic Development / Elizabeth A. Punnoose and Mark R. Lackner.
  • 2009 Springer
    Renzo Brun del Re (ed.).
  • 2010 Springer
    F.L. Greene, B.T. Heniford (eds.).
    As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.
  • 2015 Springer
    Steven N. Hochwald, editor ; Moshim Kukar, associate editor.
    This book provides detailed, comprehensive and illustrative content to the surgical community in the areas of foregut oncologic surgery. The text contains an in-depth review of all surgical aspects of oncologic diseases involving the stomach and esophagus. The main focus is on the minimally invasive techniques including potential complications and their management. The text also includes an online link to the videos for all minimally invasive foregut surgical procedures, including animation content which provide a more comprehensive learning experience. Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice is structured in a way that makes it useful at every level of training and will be of great utility to practicing surgeons, fellows in surgical subspecialty training and surgical residents.
  • 2011 Springer
    Ronald Matteotti, Stanley W. Ashley (editors).
    The past 20 years have witnessed an extraordinarily rapid adoption of minimally invasive surgical techniques, and increasingly these techniques are being employed in the diagnosis and treatment of a wide range of malignancies. This book is designed to serve as a unique and comprehensive overview of the current status of minimally invasive surgery in oncology patients and in addition offers valuable insights into the future of this constantly evolving field. The first section of the book is devoted to essential background information and to explaining what is physiologically distinctive in the cancer patient undergoing laparoscopic surgery. The second section then examines in detail a wide range of clinical aspects and issues across different disciplines, with clear instruction on the use of minimally invasive procedures. The aim is to enable the reader to make treatment decisions appropriate to the individual patient, to carry them out effectively, and to institute suitable postoperative care. Summaries of the latest knowledge in traditional therapies such as chemotherapy are also provided when appropriate. Each chapter is written by a recognized expert, and numerous high-quality illustrations are included to assist understanding. This book will serve both as a clinical reference guide and as an operative atlas, and is certain to prove invaluable in daily clinical practice.
  • 2006 Springer
    C. Stroszczynski (ed.).
    Also available: Print – 2006
  • 2009 Springer
    Keshav K. Singh, Leslie C. Costello, editors.
  • 2013 Springer
    Dhyan Chandra, editor.
    This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer.
  • 2010 Springer
    Gabriel D. Dakubo.
    1. Basic mitochondrial genetics, bioenergetics, and biogenesis -- 2. The Warburg phenomenon and other metabolic alterations of cancer cells -- 3. Mitochondrial control of apoptosis and cancer -- 4. Mitochondrial-to-nuclear communications in cancer -- 5. Types of mitochondrial genetic alterations in cancer -- 6. Mitochondrial genetic alterations in cancer I: skin, head and neck, salivary glands, thyroid, breast, lung, esophageal, gastric, colorectal, pancreatic, liver and gallbladder cancers -- 7. Mitochondrial genetic alterations in cancer II: renal, urinary bladder, prostate, ovarian, endometrial, cervical, nervous system, hemoatologic and connective tissue cancers -- 8. Mitochondrial genome rearrangement and copy number changes in cancer -- 9. Functional importance of mitochondrial genetic alterations in cancer -- 10. The role of mitochondrial reactive oxygen species in cancer -- 11. Mitochondrial DNA measurement in exfoliated cells for cancer detection and monitoring: the copy number advantage -- 12. Early cancer detection and monitoring using changes in the mitochondrial genome as biosensors -- 13. Analysis of mitochondrial genome alterations in cancer -- 14. "Mitocans": agents targeting mitochondria to kill cancer cells -- Index.
  • Pt. A: v. 1-6; Pt. B: v. 7-12, 2012.
    American College of Physicians ; editor-in-chief, Patrick C. Alguire.
    Status: Not Checked OutLane Catalog Record
    Part A -- [v. 1] Cardiovascular medicine -- [v. 2] Dermatology -- [v. 3] Gastroenterology and hepatology -- [v. 4] Hematology and oncology -- [v. 5] Neurology -- [v. 6] Rheumatology -- [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative index.
  • 2011 Atypon
    Denise Guliato, Rangaraj M. Rangayyan.
    Malignant tumors due to breast cancer and masses due to benign disease appear in mammograms with different shape characteristics: the former usually have rough, spiculated, or microlobulated contours, whereas the latter commonly have smooth, round, oval, or macrolobulated contours. Features that characterize shape roughness and complexity can assist in distinguishing between malignant tumors and benign masses. In spite of the established importance of shape factors in the analysis of breast tumors and masses, difficulties exist in obtaining accurate and artifact-free boundaries of the related regions from mammograms. Whereas manually drawn contours could contain artifacts related to hand tremor and are subject to intra-observer and inter-observer variations, automatically detected contours could contain noise and inaccuracies due to limitations or errors in the procedures for the detection and segmentation of the related regions. Modeling procedures are desired to eliminate the artifacts in a given contour, while preserving the important and significant details present in the contour.
  • 2012 Springer
    Trachette L. Jackson, editor ; foreword by Luisa Iruela-Arispe.
  • 2013 Springer
    Wan Tang, Xin Tu, editors.
    This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens. The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.
  • 2015 Springer
    Riccardo A. Audisio, James G. Geraghty, and Walter E. Longo, editors.
  • 2010 Springer
    Srinivasan Yegnasubramanian, William B. Isaacs, editors.
    Genome-Scale Analysis of Data from High-Throughput Technologies / Sarah J. Wheelan -- Analysis of Inherited and Acquired Genetic Variation / Srinivasan Yegnasubramanian and William B. Isaacs -- Examining DNA-Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis / Esteban Ballestar and Manel Esteller -- Genome-Wide DNA Methylation Analysis in Cancer Research / Srinivasan Yegnasubramanian and William G. Nelson -- Use of Expression Microarrays in Cancer Research / Jun Luo and Yidong Chen -- Signal Sequencing for Gene Expression Profiling / Biaoyang Lin, Jeremy Wechsler and Leroy Hood -- Mass Spectrometry Based Proteomics in Cancer Research / Mohamad A. Abbani, Parag Mallick and Maryann S. Vogelsang -- Tissue Microarrays in Cancer Research / Toby C. Cornish and Angelo M. De Marzo.
  • 2010
    Mark Ping Chao.
    Growing evidence indicates that cancers are composed of functionally heterogeneous cells that are organized by a cellular hierarchy and are maintained by a stem cell-like population. Given their unique ability to initiate tumor growth, eradication of these cancer stem cells (CSC) is necessary for cure. Thus, the development of CSC targeted therapies is necessary to improve current clinical outcomes. This body of work identifies CD47 as a therapeutic target on CSC and bulk cells in several human malignancies. CD47 is a cell surface protein that functions to inhibit phagocytosis through binding its ligand SIRP[Alpha], expressed on phagocytes. Compared to normal cell counterparts, CD47 was highly expressed on several human tumors including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and non-Hodgkin lymphoma (NHL), suggesting that higher CD47 levels on tumors allow evasion of immune phagocytosis. Higher CD47 expression in these tumors correlated with a worse clinical prognosis and was an independent prognostic factor. Furthermore, a monoclonal blocking antibody against CD47 enabled phagocytosis of human AML, ALL, and NHL in vitro and eliminated disease in vivo. When combined with the Fc receptor-activating antibody, rituximab, anti-CD47 antibody therapy achieved high cure rates in pre-clinical models of NHL in contrast to partial responses with either agent alone. Lastly, anti-CD47 antibody treatment specifically targeted tumor but not normal cells, resulting in minimal toxicity in vitro and in vivo. The selective targeting of tumor cells by anti-CD47 antibody was due to the selective expression of the pro-phagocytic signal, calreticulin on tumor but not normal cells. In summary, this body of work identifies CD47 as a therapeutic target on several human cancers and that a monoclonal blocking antibody against CD47 has pre-clinical efficacy in eliminating these tumors through the promotion of phagocytosis.
  • 2009 Springer
    Kathleen Sakamoto, Eric Rubin, editors.
  • 2012 Springer
    Keyvan Nouri, editor.
    An Introduction to Mohs Micrographic Surgery -- Indications for Mohs Micrographic Surgery -- Preoperative Evaluation -- Mohs Micrographic Surgery Operative Room Setup -- Anesthetic Considerations: Local Versus Regional -- Cutaneous Anatomy in Mohs Micrographic Surgery -- Mohs Surgery: Fixed Tissue Technique -- Fresh Tissue Technique -- Special Considerations for Mohs Micrographic Surgery in Organ Transplant Recipients -- Mohs Micrographic Surgery in Ethnic Skin -- Histopathology Laboratory Setup and Necessary Instrumentation -- Tissue Transport and Initial Processing Cryostat Preparation of Slides -- Histopathologic Interpretation of Mohs Slides -- Tissue Specimen Documentation, Record Keeping, and Sample Storage -- Immunostains -- Basal Cell Carcinoma -- Squamous Cell Carcinoma -- Mohs Micrographic Surgery for the Treatment of Cutaneous Melanoma -- Dermatofibrosarcoma Protuberans -- Microcystic Adnexal Carcinoma -- Atypical Fibroxanthoma -- Extramammary Paget Disease -- Leiomyosarcoma -- Merkel Cell Carcinoma -- Selected Sweat Gland Carcinomas -- Sebaceous Carcinoma -- Mohs Micrographic Surgery for the Eyelid -- Mohs Surgery for Periungual and Subungual Skin Cancer -- Genitalia -- Deep Structures of the Head and Neck -- Complications of Mohs Micrographic Surgery -- Eyelid Reconstruction After Mohs Micrographic Surgery -- Flaps -- Skin Grafting -- Side to Side Closure After Mohs Surgery -- Prosthetic Rehabilitation -- Combination Therapy for the Nonsurgical Treatment of Skin Cancers: Latest Research at Mount Sinai -- Training and Regulation in Mohs Surgery -- Establishing a Mohs Practice -- International Perspective of Mohs Micrographic Surgery: South America -- International Perspective of Mohs Micrographic Surgery: Europe -- International Perspective of Mohs Micrographic Surgery: East Asia -- International Perspective of Mohs Micrographic Surgery: Australia and New Zealand -- Information for Patients and Safety Considerations -- Ethical Issues Related to Mohs Skin Cancer Surgery -- Medicolegal Issues Regarding Mohs Micrographic Surgery -- Psychological Issues Regarding Mohs Micrographic Surgery.
  • 2005 Cold Spring Harb Lab Press
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    meeting organized by Bruce Stillman and David Stewart.
    Cancer genetics and genomes -- DNA damage response -- Cancer biology and stem cells -- Telomeres, senescence, and aging -- Animal models for cancer -- Gene expression and cancer -- Tumor responses to microenvironment -- Angiogenesis -- Discovering cancer targets -- Therapeutic approaches.
  • 2012 Springer
    Michał Witt, Małgorzata Dawidowska, Tomasz Szczepánski, editors.
    Part 1. Molecular Biology of Selected Hemato-oncologic Diseases -- Molecular Biology of Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich and Tomasz Szczepański -- Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia / Agata A. Filip, Marta Libura, Sebastian Giebel and Olga Haus -- Molecular Pathogenesis of Aggressive B-cell Lymphomas / Przemysław Juszczyński and Krzysztof Warzocha -- Molecular Biology and Classification of Multiple Myeloma / Anna Dmoszyńska and Norbert Grząśko -- Chronic Lymphocytic Leukemia / Anton W. Langerak and Yorick Sandberg -- Molecular Biology of Chronic Myeloid Leukemia / Tomasz Sacha, Kajetana Foryciarz and Aleksander B. Skotnicki -- Molecular Biology of Myelodysplastic Syndromes / Francesc Solé -- Myeloproliferative Neoplasms / Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner and Aleksandra Leszczyńska -- Part 2. Diagnostics and Monitoring of Therapy of Hemato-oncologic Deseases -- Flow Cytometric Immunophenotyping as Diagnostic Tool of Hematopoietic Malignancies / Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena and Julia Almeida, et al. -- Cytogenetics in Hematology / Olga Haus, Anna Poluha and Katarzyna Skonieczka -- Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Tomasz Szczepański, Małgorzata Dawidowska and Katarzyna Derwich -- Gene Expression Profiling in Hematologic Malignancies / Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak and Krzysztof Warzocha -- Part 3. Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation -- Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Wachowiak -- Genetic Basis of Donor-Recipient Matching in Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Nowak and Jacek Wachowiak -- Chimerism Following Allogeneic Transplantation of Hematopoietic Stem Cells / Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak and Michał Witt -- Peritransplantation Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Katarzyna Derwich and Tomasz Szczepański -- Biobanks of Cellular Material / Wiesław Wiktor-Jędrzejczak and Elżbieta Urbanowska -- Part 4. Molecular Diagnostic Protocols -- Biobanking of Cellular Material / Anna Poluha and Elżbieta Urbanowska -- Isolation of Mononuclear Cells from Human Blood and Bone Marrow by Density Gradient Centrifugation / Małgorzata Dawidowska -- Molecular Techniques Commonly Used in Hemato-oncology / Monika D. Kraszewska and Ewa Ziętkiewicz -- Genetic Methods of HLA Typing / Jacek Nowak, Renata Mika-Witkowska and Elżbieta Graczyk-Pol -- Post-Transplant Chimerism Analysis Through STR-PCR and RQ-PCR / Małgorzata Dawidowska, Katarzyna Guz, Agnieszka Orzińska, Justyna Smolarczyk-Wodzyńska and Monika D. Kraszewska, et al. -- Analysis of Minimal Residual Disease with the Use of Rearrangements of Ig/TCR Genes Through RQ-PCR / Małgorzata Dawidowska, Vincent H. J. van der Velden, Michał Witt and Tomasz Szczepański -- Molecular Diagnostics of Acute Myeloblastic Leukemia / Marta Libura, Agata A. Filip and Olga Haus -- Assessment of the Presence and the Level of BCR-ABL Fusion Gene Expression and Mutational Status in ABL Kinase Domain / Sylwia Czekalska, Magdalena Zawada and Izabela Florek -- Studies of Rearrangements and Somatic Hypermutation of IGHV Genes in Chronic Lymphocytic Leukemia / Anton W. Langerak, Richard Rosenquist, Paolo Ghia, Chrysoula Belessi and Kostas Stamatopoulos, et al. -- Molecular Biology Methods in the Diagnosis of Multiple Myeloma / Anna Dmoszyńska and Sylwia Chocholska -- Molecular Methods in Myeloproliferative Neoplasms / Aleksandra Leszczyńska, Witold Prejzner, Maria Bieniaszewska and Andrzej Hellmann -- Informed Consent for Participation in Research Project / Małgorzata Dawidowska and Michał Witt.
  • 2010 Springer
    Dirk P. Dittmer, Susan E. Krown, editors.
    Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well. Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.
  • 2015 ClinicalKey
    [edited by] John Mendelsohn, Joe W. Gray, Peter M. Howley, Mark A. Israel, Craig B. Thompson.
    Cancer : a genetic disorder / William C. Hahn, Robert A. Weinberg -- Oncogenes and signal transduction / Luca Grumolato, Stuart A. Aaronson -- Tumor suppressor genes / Nelson E. Brown, Philip W. Hinds -- DNA repair pathways and human cancer / Alan D. D'Andrea -- Epigenetics and cancer / Stephen B. Baylin -- Infectious agents and cancer / Peter M. Howley -- Environmental carcinogenesis / Erika L. Abel, John DiGiovanni -- Animal models : flies, fish, and yeast / Elspeth Payne, A. Thomas Look -- Genetic mouse models of cancer / Monte M. Winslow, Tyler Jacks -- Cancer stem cells and the microenvironment / Hasan Korkaya, April Davis, Max S. Wicha -- Regulation of the cell cycle / Yan Li, Olena Barbash, J. Alan Diehl -- Cell growth / David A. Guertin, David M. Sabatini -- Metabolism of cell growth and proliferation / Lydia W.S. Finley, Craig B. Thompson -- Apoptosis, necrosis, and autophagy / Eileen White, Douglas R. Green, Anthony G. Letai -- Cellular senescence / Jessica E. Bolden, Scott W. Lowe -- Role of the microenvironment in tumor initiation, progression, and metastasis / Cyrus M. Ghajar, Ana Luísa Correia, Mina J. Bissell -- Tumor angiogenesis / Brian Keith, M. Celeste Simon -- Invasion and metastasis / Swarnali Acharyya, Lynn Matrisian, Danny R. Welch, Joan Massagué -- Inflammation and cancer / Daniela F. Quail, Johanna A. Joyce -- Cancer systems biology : the future / Andrea Califano -- Biomarkers for assessing risk of cancer / Xifeng Wu, Jian Gu -- Protein biomarkers for detecting cancer : molecular screening / Susan Fisher, H. Ewa Witkowska -- Technology of analyzing nucleic acids in Cancer / Elaine R. Mardis -- Understanding and using information about cancer genomes / Paul T. Spellman, Josh Stuart, Joe W. Gray -- High-content analysis with cellular and tissue systems biology : a bridge between cancer cell biology and tissue-based diagnostics / Albert Gough, Timothy Lezon, James R. Faeder, Chakra Chennubhotla, Robert F. Murphy, Rebecca Critchley-Thorne, D. Lansing Taylor -- Molecular genetics of acute lymphoblastic leukemia / Eric S. Schafer, Judith Margolin, David G. Poplack, Karen R. Rabin -- Molecular biology of childhood neoplasms / David Malkin -- Biology of adult myelocytic leukemia and myelodysplasia / Sean M. Post, Hagop Kantarjian, Alfonso Quintás-Cardama -- Lymphoma / Owen A. O'Connor, Jennifer Amengual, Changchun Deng, Ahmed Sawas, Bachir Alobeid, Daniela Hoehn, Govind Bhagat -- Multiple myeloma / Giovanni Tonon, Kenneth C. Anderson -- Molecular mechanisms of esophageal cancer / Mario D. Terán, Ronan Kelly, Malcolm V. Brock -- Molecular basis of lung cancer / Jill E. Larsen, Ramaswamy Govindan, John D. Minna -- Molecular pathogenesis of head and neck cancer / Matthew L. Hedberg, Jennifer R. Grandis -- Colon and rectal cancer / Eric R. Fearon -- Molecular pathogenesis of pancreatic adenocarcinoma / Rachna T. Shroff, James L. Abbruzzese -- Molecular biology of breast cancer / Adrian V. Lee, Steffi Oesterreich, Nancy E. Davidson -- Molecular pathogenesis of ovarian cancer / Robert C. Bast Jr., Ignacio Romero, Gordon B. Mills -- Molecular basis of prostate cancer / Long-Cheng Li, Andrew C. Hsieh, Davide Ruggero, Kirsten L. Greene, Peter R. Carroll -- Molecular abnormalities in kidney cancer / Sabina Signoretti, Toni K. Choueiri, William G. Kaelin Jr. -- Biology of primary brain tumors / Matthew C. Havrda, Mark A. Israel -- Epithelial skin cancer / Adam B. Glick, Stuart H. Yuspa -- Molecular basis for treating cutaneous molecular / Marc S. Ernstoff -- Thyroid cancer / Steven I. Sherman -- Soft tissue sarcomas / Julie D.R. Reimann, Christopher D.M. Fletcher -- From bench to bedside with targeted therapies / John Mendelsohn -- Cancer therapeutics / William N. Hait, Eric Rubin, Joseph R. Bertino -- Natural and acquired resistance to cancer therapies / Branimir I. Sikic -- Phase I trials today / Daniel Morgensztern, Patricia M. LoRusso, Scott A. Boerner, Roy S. Herbst, Joseph Paul Eder -- Pharmacogenomics / Peter H. O'Donnell, Mark J. Ratain -- Monoclonal antibodies for the treatment of cancer / Louis M. Weiner, Rishi Surana -- Cancer and the cellular immune response / Patrick Hwu, Gregory Lizée, Yong-Jun Liu -- Cancer immunotherapy with vaccines and checkpoint blockade / Drew Pardoll -- Interferons / Ernest C. Borden -- Gene therapy and oncolytic viruses / Tanja Meyer Tamguney, W. Michael Korn, Frank McCormick -- RNA as a therapeutic molecule / George Adrian Calin, Carlo Maria Croce -- Heat shock protein 90 and the proteasome : housekeeping proteins that are also molecular targets for cancer therapy / Len Neckers, Mehdi Mollapour -- Hematopoietic growth factors and cytokines / Suhendan Ekmekcioglu, Razelle Kurzrock, Elizabeth A. Grimm -- Cancer chemoprevention / Scott M. Lippman, J. Jack Lee -- Molecular pathology / Christopher L. Corless.
  • 2005 Springer
    by Wolfgang Arthur Schulz.
  • 2006 CRCnetBASE
    edited by David Warshawsky, Joseph R. Landolph, Jr.
    Carcinogens and mutagens -- Whole animal carcinogenicity bioassays -- Molecular mechanisms of action of selected organic carcinogens -- Binding of carinogens to DNA and covalent adducts and DNA damage - PAH, aromatic amines, nitro-aromatic compounds, and halogenated compounds -- Cellular oncogenes and carcinogenesis -- Tumor suppressor genes -- Hepatitis B, Hepatitis C, and hepatocellular carcinoma -- Oncongenesis in transgenic and knockout mice -- Chemically induced morphological and neoplastic transformation in C3H/10T1/2 C1 8 mouse embryo cells -- Radiation carcinogenesis -- DNA microarrays and computational analysis of DNA microarray data in cancer research -- Application of proteomics in basic biological sciences and cancer -- Overview of human cancer induction and human exposure to carcinogens -- Complex mixtures of chemical carcinogens: principles of action and human cancer -- Lung cancer -- Breast cancer -- Cancer of the prostate - Mechanisms of molecular carcinogenesis -- Skin cancer: epidemiology, clinical manifestations, and genetic and molecular aspects -- Cell and molecular biology of cancer of the brain --Thyroid cancer: molecular biology and clinical aspects -- Chemoprevention of chemical carcinogenesis and human cancer -- Carcinogen biomarkers and exposure assessment -- Risk assessment for chemical carcinogens -- Prevention and regulation approaches to carcinogens.
    Also available: Print – 2006
  • 2014 Springer
    Barbara Burtness, Erica Golemis, editors.
    Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
  • 2011 Springer
    Theodore L. DeWeese, Marikki Laiho, editors.
    H2AX in DNA Damage Response -- DNA Damage Signaling Downstream of ATM -- Checkpoint Control Following Radiation Exposure -- Chromatin Responses to DNA Damage -- Caenorhabditis elegans Radiation Responses -- Hypoxia and Modulation of Cellular Radiation Response -- Inhibitors of DNA Repair and Response to Ionising Radiation -- Gene Therapy and Radiation -- Molecular Targeted Drug Delivery Radiotherapy -- EGFR Signaling and Radiation -- Thermal Modulation of Radiation-Induced DNA Damage Responses -- Radiation-Induced Immune Modulation.
  • 2010 CRCnetBASE
    editors, Jan Trøst Jørgensen, Henrik Winther.
    This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.The book is the first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine. The different chapters of the book are authored by key opinion leaders, each representing their specialized areas, which provide the reader with expertise knowledge in the field.
  • 2014 ClinicalKey
    edited by Asfar S. Azmi.
    Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
  • 2014 Springer Protocols
    edited by Magdalena Thurin, Francesco M. Marincola.
    Novel insights/translational implication from the emerging biology of melanoma / Antoni Ribas -- Emerging clinical issues in melanoma in the molecularly targeted era / Ryan J. Sullivan and Michael B. Atkins -- Integrating molecular biomarkers into current clinical management in melanoma / Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak -- Advances in adjuvant therapy : potential for prognostic and predictive biomarkers / Diwakar Davar [and three others] -- Immunologic monitoring of cancer vaccine trials using the ELISPOT assay / Lisa H. Butterfield and Mary Jo Buffo -- Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma / Michael A. Postow [and four others] -- Marker utility for combination therapy / Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto -- Assaying for BRAF V600E in tissue and blood in melanoma / David J. Panka, James W. Mier, and Ryan J. Sullivan -- Selecting patients for KIT inhibition in melanoma / Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu -- Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma / Roger S. Lo and Hubing Shi -- Current status of diagnostic and prognostic markers in melanoma / Danielle Levine and David E. Fisher -- Chromosomal copy number analysis in melanoma diagnostics / Jeffrey P. North, Swapna S. Vemula, and Boris C. Bastian -- Construction and analysis of multiparameter prognostic models for melanoma outcome / Bonnie E. Gould Rothberg and David L. Rimm -- Immunohistochemical diagnostic and prognostic markers for melanoma / Mehdi Nosrati and Mohammed Kashani-Sabet -- Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma / Xiaowei Xu [and four others] -- Tumor-infiltrating lymphocytes and their significance in melanoma prognosis / Tobias Schatton [and three others] -- Pathological staging of melanoma / David E. Elder -- Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis / Lisa Villabona [and three others] -- B7-H abnormalities in melanoma and clinical relevance / Barbara Seliger -- Melanoma susceptibility genes and risk assessment / Alexander Marzuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao -- Clinical, pathologic, and imaging features and biological markers of uveal melanoma / Alia B. Rashid and Hans E. Grossniklaus -- Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile / J. William Harbour -- Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma / Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens -- ERBB4 mutation analysis : emerging molecular target for melanoma treatment / Christopher Lau [and three others] -- Epigenetic markers of prognosis in melanoma / Luca Sigalotti [and four others] -- Isolation of melanoma cell subpopulations using negative selection / Ana Slipicevic [and three others] -- Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients / Eiji Kiyohara [and three others] -- Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma / Yangyang Wang [and three others] -- Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma / Brian A. Boone and Michael T. Lotze -- The clinical use of PET/CT in the evaluation of melanoma / Khun Visith Keu and Andrei H. Iagaru -- Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy / Alessandra Cesano and David Spellmeyer -- Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to prdict metastasis / Kim R.M. Blenman and Peter P. Lee -- COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing / Elena Castellanos-Rizaldos [and seven others] -- Isolation of circulating microRNAs from microvesicles found in human plasma / John F. Quackenbush [and seven others] -- Detection of circulating tumor cells by photoacoustic flowmetry / Ryan M. Weight and John A. Viator -- Statistical design and evaluation of biomarker studies / Kevin K. Dobbin -- Tissue resources for clinical use and marker studies in melanoma / Jonathan L. Curry [and five others].
  • 2011 Springer
    Xin Wei Wang, Joe W. Grisham, Snorri S. Thorgeirsson, editors.
    Part I. Introduction -- Ch. 1. Biology of heptocellular carcinoma: past, present and beyond -- Ch. 2. Overview of cholangiocarcinoma and evidence for a primary liver carcinoma spectrum -- Part II. Liver cancer development and pathogenesis -- Ch. 3. Pathology of hepatocellular carcinoma -- Part III. Genetics and epidemiology of liver cancer -- Ch. 4. Epidemiology of heptocellular carcinoma -- Ch. 5. Genetics and epidemiology of cholangiocarcinoma -- Part IV. Molecular basis of cancer susceptibility -- Ch. 6. Signaling pathways in viral related pre-neoplastic liver disease and heptocellular carcinoma -- Ch. 7. Epigenetic effects of persistent Hepatitis C virus infection and hepatocellular carcinoma -- Ch. 8. DNA methylation status in chronic liver disease and hepatocellular carcinoma -- Part V. Animal modes -- Ch. 9. Transgenic and knockout mouse models of liver cancer -- Ch. 10. Mosaic cancer mouse models and functional oncogenomics in hepatocellular carcinoma -- Ch. 11. The zebrafish model for liver carcinogenesis -- Part Vi. Global gene expression profiling of human liver cancer -- Ch. 12. Integrative and functional genomics of HCC -- Ch. 13. Molecular signatures of heptocellular carcinoma metastasis -- Ch. 14. Gene mutations and transcriptomic profiles associated to specific subtypes of hepatocellular tumors -- Part VII. Cancer stem cells -- Ch. 15. Cancer stem cells and liver cancer -- Ch. 16. Heterogeneity of liver cancer stem cells -- Ch. 17. Cancer stem cells in liver carcinoma -- Part VIII. Liver cancer genetics in the clinic -- Ch. 18. Moleuclar signaling in hepatocellular carcinoma -- Ch. 19. Molecular events on metastasis of hepatocellular carcinoma -- Ch. 20. Molecular pathogenesis of hepatocellular carcinoma -- Subject Index.
  • 2013 Springer
    Diane M. Simeone, Anirban Maitra, editors.
    Genomic Alterations in Sporadic Pancreatic Cancer / Marco Dal Molin, Anirban Maitra -- Molecular Pathology of Pancreatic Cancer Precursor Lesions / Lodewijk A. A. Brosens, G. Johan Offerhaus -- Genetic Epidemiology and Pancreatic Cancer / Li Jiao, Donghui Li -- Translational Implications of Molecular Genetics for Early Diagnosis of Pancreatic Cancer / Michael A. Hollingsworth -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer / Helen Court, Mark R. Philips, Dafna Bar-Sagi -- Molecular Targeted Therapies in Pancreatic Cancer / Edward Kim, Ethan V. Abel, Arunima Ghosh -- Mouse Models of Pancreatic Ductal Adenocarcinoma / Filip Bednar, Marina Pasca di Magliano -- The Genetics of Pancreatic Cancer Progression / Christine A. Iacobuzio-Donahue, -- Epigenetic Alterations in Pancreatic Cancer / Michael Ayars, Michael Goggins -- Innovative Technologies in the Molecular Characterization of Pancreatic Cancer / Iris H. Wei, Chandan Kumar-Sinha.
  • 2013 Springer
    Ottmar Schober, Burkhard Riemann, editors.
    The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing significantly. The process of molecular imaging includes key biotarget identification, design of specific molecular imaging probes, and their preclinical evaluation, e.g., in vivo using small animal studies. A multitude of such innovative molecular imaging probes have already entered clinical diagnostics in oncology. There is no doubt that in future the emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation that will optimize diagnostic processes.This handbook addresses all aspects of molecular imaging in oncology, ranging from basic research to clinical applications in the era of evidence-based medicine. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
  • 2006 Springer
    [edited by] Jörg Reichrath.
    The epidemiology of basal cell and squamous cell carcinoma / Hao Wang and Thomas L. Diepgen -- Histology of epithelial skin tumors / Jörg Reichrath and Kerstin Querings -- UV damage and DNA repair in basal cell and squamous cell carcinomas / Knuth Rass -- Papillomavirus infections and cancerogenesis of squamous cell and basal cell carcinomas / Guido Bens -- The immune system and nonmelanoma skin cancers / Elma D. Baron -- Cytogenetics of basal cell carcinoma and squamous cell carcinomas / Melanie A. Carless, Kevin J. Ashton and Lyn R. Griffiths -- The hedgehog signaling pathway and epithelial skin cancer / Julia Reifenberger -- p53 protein and nonmelanoma skin cancer / Vladislava O. Melnikova and Honnavara N. Ananthaswamy -- TGF-[beta] pathway and cancerogenesis of epithelial skin tumors / Miguel Quintanilla ... [et al.] -- PDGF pathways and growth of basal cell and squamous cell carcinomas / Jingwu Xie -- Apoptosis and cancerogenesis of basal cell and squamous cell carcinoma / Peter Erb ... [et al.] -- The role of telomerase for cancerogenesis of basal cell and squamous cell carcinomas / Eva-Maria Fabricius.
  • 2007 Springer
    Georg F. Weber.
    Theories of carcinogenesis -- Physioloigic correlates of malignancy -- Cell division and survival -- Cellular senescence -- Invasiveness -- DNA repair -- Epigenetic regulation of cancer-associated gene products -- Interaction of the groups of cancer-related gene products -- Structural growth control -- The organ preference of metastasis formation -- Angiogenesis -- Interactions with the immune system -- Endocrine dysregulation -- Dormancy and minimal residual disease -- Epithelial tumors -- Hematologic malignancies -- Mesenchymal tumors -- Neurologic tumors -- Tumors of serous cavities -- Embryonic tumors.
  • 2013 Springer
    Benjamin Bonavida, editor.
    Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
  • 2011
    Kartik Viswanathan.
    Pancreatic [Beta]-cells secrete insulin to maintain systemic glucose balance. In response to physiological or pathological stresses that increase insulin demand, [Beta]-cells proliferate and enhance insulin secretion to increase insulin output. However, the mechanisms that govern these facultative changes are unclear. In this thesis, I investigate two potential factors in achieving these essential adaptive changes -- hypoxia inducible factor 1 alpha (Hif1a) and prolactin receptor (Prlr). During pregnancy, a common acquire state with increased insulin demand, Hif1a and Hif1a target gene expression, including Vegfa, Glut1, Gck were increased in maternal islets. Using mouse genetics, conditional deletion of Hif1a in [Beta]-cells ([Beta]Hif1a KO) resulted in glucose intolerance in pregnant, but not virgin, mice. Pregnant [Beta]Hif1a KO mice had impaired target gene expression, defective islet insulin secretion, and reduced vascularity. Pregnant mice develop transient hyperlipidemia, and recapitulation of the hyperlipidemia with fat-challenge or lipid treament induced Hif1a, Vegfa, and Pgk1 expression. Similar to pregnant [Beta]Hif1a KO mice, fat-challenged [Beta]Hif1a KO developed hyperglycemia, hypoinsulinemia, and glucose intolerance. All three hyperlipidemic states show ER stress, and treatment of unstressed mouse or human islets with thapsigargin was sufficient to increase Hif1a and downstream targets. To assess the significance of prolactin signaling in [Beta]-cell function and proliferation in adaptive settings, I created a novel conditional Prlr mouse model. In non-pregnant mice with [Beta]-cell-specific deletion of Prlr ([Beta]Prlr KO), glucose homeostasis is normal. However, pregnant [Beta]Prlr KO mice developed significant glucose intolerance. Given the widespread effects of lactogens on [Beta]-cell physiology, I anticipate altered [Beta]-cell proliferation and secretion in [Beta]Prlr KO islets, and current studies are underway to address this hypothesis. Collectively, our work has revealed that in settings of insulin resistance, both Hif1a and Prlr signaling play important roles in regulating the physiological changes required for proper [Beta]-cell function.
  • 2015 Springer
    Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett, editors.
    Part I. Overview of Basic Cellular Biology -- 1. Normal molecular biology and definition of terms -- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins -- 3. Standard nomenclature -- introduction and brief overview -- Part II. Molecular Oncology Methodology -- 4. General principles of Oncology testing -- 5. Molecular methodologies -- 6. General principles of validating a molecular test -- Part III. Molecular testing in Solid Tumors -- 7. Lung and mediastinum -- 8. Breast -- 9. Head and neck (salivary glands) -- 10. Thyroid and parathyroid (endocrine) -- 11. Gastrointestinal and Pancreatobiliary -- 12. Soft tissue -- 13. Genitourinary system -- 14. Central Nervous System -- 15. Skin and adnexa -- 16. Common Hereditary Cancer Syndromes -- Part IV. The future is here -- 17. Application of next generation sequencing -- Part V. Quality Assurance and Regulatory affairs -- 18. Quality Assurance -- pre-analytic, analytic and post-analytic -- 19. Regulatory affairs (including accreditation) -- 20. Coding and re-imbursement.
  • 2013 Springer
    Kevin M. Maigis, editor.
    Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
  • 2014 Springer
    edited by Domenico Coppola.
    Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
  • 2007 Springer
    edited by Antonio Giordano, Alessandro Bovicelli, Robert J. Kurman.
  • 2010 Springer
    edited by Cherie H. Dunphy.
    Section I. Molecular Pathology of Hematolymphoid Neoplasms: General Principles -- Molecular Oncogenesis / Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, and Falko Fend -- Genetic Predispositions for Hematologic and Lymphoid Disorders / Frederick G. Behm -- Prognostic Markers / David Bahler -- Cancer Stem Cells: Potential Targets for Molecular Medicine / Isabel G. Newton and Catriona H.M. Jamieson -- Gene Therapy for Leukemia and Lymphoma / Xiaopei Huang and Yiping Yang -- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression) / Richard J.Q. McNally -- Viral Oncogenesis / Alexander A. Benders and Margaret L. Gulley -- Section II. Specific Techniques and Their Applications in Molecular Hematopathology -- Techniques to Determine Clonality in Hematolymphoid Malignancies / Daniel E. Sabath -- Techniques to Detect Defining Chromosomal Translocations/Abnormalities / Jennifer J.D. Morrissette, Karen Weck, and Cherie H. Dunphy -- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease / Marie E. Beckner and Jeffrey A. Kant -- Detection of Resistance to Therapy in Hematolymphoid Neoplasms / Karen Weck -- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting / Jessica K. Booker -- Gene Expression Profiling / Cherie H. Dunphy -- Proteomics of Human Malignant Lymphoma / Megan S. Lim, Rodney R. Miles, and Kojo S.J. Elenitoba-Johnson -- Mouse Models of Hematolymphoid Malignancies / Krista M.D. La Perle and Suzana S. Couto -- Section III. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes -- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Patricia Aoun -- Marginal Zone B-Cell Lymphoma / Lynne V. Abruzzo and Rachel L. Sargent -- Lymphoplasmacytic Lymphoma / Pei Lin -- Molecular Pathology of Plasma Cell Neoplasms / James R. Cook -- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma / W. Richard Burack -- Mantle Cell Lymphoma / Kai Fu and Qinglong Hu -- Diffuse Large B-Cell Lymphomas / Cherie H. Dunphy -- The Molecular Pathology of Burkitt Lymphoma / Claudio Mosse and Karen Weck -- Precursor B-Cell Acute Lymphoblastic Leukemia / Julie M. Gastier-Foster -- Molecular Genetics of Mature T/NK Neoplasms / John P. Greer, Utpal P. Davé, Nishitha Reddy, Christine M. Lovly, and Claudio A. Mosse -- Precursor T-Cell Neoplasms / Kim De Keersmaecker and Adolfo Ferrando -- Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma / Michele Roullet and Adam Bagg -- Posttransplant Lymphoproliferative Disorder / Margaret L. Gulley -- AIDS-Related Lymphomas / Amy Chadburn and Ethel Cesarman -- Chronic Myelogenous Leukemia / Dan Jones -- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms / Mike Perez and Chung-Che (Jeff) Chang -- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid, and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis / Robert P. Hasserjian -- Molecular Pathogenesis of Myelodysplastic Syndromes / Jesalyn J. Taylor and Chung-Che "Jeff" Chang -- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemias with Normal Cytogenetics / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia / Sergej N. Konoplev and Carlos E. Bueso-Ramos -- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders / Murat O. Arcasoy and Patrick G. Gallagher -- White Blood Cell and Immunodeficiency Disorders / John F. Bastian and Michelle Hernandez -- Molecular Basis of Disorders of Hemostasis and Thrombosis / Alice Ma -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Castleman's Disease / Richard Flavin, Cara M. Martin, Orla Sheils, and John James O'Leary -- Molecular Pathology of Histiocytic Disorders / Mihaela Onciu -- Reactive Lymphadenopathies: Molecular Analysis / Dennis P. O'Malley -- Molecular Pathology of Infectious Lymphadenitides / Kristin Fiebelkorn -- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders / Kareem N. Washington, John F. Tisdale, and Matthew M. Hsieh.
  • 2012 Springer
    Philip T. Cagle...[et al.], editors.
    Part 1. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient / Philip T. Cagle -- Etiology of Lung Cancer / Philip T. Cagle -- Genetic Susceptibility to Lung Cancer / Timothy Craig Allen -- Lung Cancer Stem Cells / Timothy Craig Allen -- The Classification of Pre-invasive Lesions / Keith M. Kerr -- Molecular Pathology of Precursor and Pre-invasive Lesions / Keith M. Kerr -- Revised Classification for Adenocarcinoma / Philip T. Cagle and Keith M. Kerr -- Molecular Basis for the Current Lung Cancer Classification / Alain C. Borczuk -- Molecular Diagnosis of Lung Cancer / Lucian R. Chirieac and Philip T. Cagle -- Molecular Targeted Therapy of Lung Cancer / Sanja Dacic -- Molecular Prognostic Markers of Lung Cancer / Sanja Dacic -- New Techniques for Optical and Molecular Visualization of Lung Cancer / Philip T. Cagle -- Part 2. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma / Keith M. Kerr -- Squamous Cell Carcinoma / Timothy Craig Allen -- Molecular Pathology of Large Cell Carcinoma / Alain C. Borczuk -- Molecular Pathology of Small Cell Carcinomas / Mary Beth Beasley -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma / Mary Beth Beasley -- Molecular Pathology of Uncommon Carcinomas / Alain C. Borczuk -- Biology of Lung Cancer Metastases / Lucian R. Chirieac.
  • 2013 Springer
    Antonia R. Sepulveda, John P. Lynch, editors.
    Introduction -- Mechanisms of Gastrointestinal Carcinogenesis /Frank I. Scott, John P. Lynch -- Epithelial Neoplastic Disease -- Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers /Davendra Sohal, Antonia R. Sepulveda, Weijing Sun -- Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma /Mamoun Younes -- Molecular Pathology of Squamous Carcinomas of the Esophagus /Rohinton S. Tarapore, Jonathan P. Katz -- Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers /Shuko Harada, Antonia R. Sepulveda -- Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes /Fátima Carneiro, Carla Oliveira, Raquel Seruca -- Cancer Predisposition Syndromes of the Gastrointestinal Tract /Ian S. Hagemann, Antonia R. Sepulveda -- Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type /Asif Rashid -- Cancers of the Rectum and Anal Canal /Jenia Jenab-Wolcott, Bruce Giantonio -- Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia /Takeshi Uehara, Deqin Ma, Antonia R. Sepulveda -- Non-Epithelial Neoplastic Tumors -- Molecular Biology and Pathology of Gastrointestinal Stromal Tumors /Paul J. Zhang -- Neuroendocrine Tumors /Joseph R. Pisegna -- Metastatic Disease and Tumor Markers -- Molecular Mechanisms of Tumor Metastasis /Andrew D. Rhim, Davendra Sohal, Hiroshi Nakagawa -- Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis /Loren Joseph -- Serological Markers of Digestive Tract Cancers /Jorge L. Sepulveda.
  • 2015 Springer
    Matthias A. Karajannis, David Zagzag, editor.
    This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
  • 2012 ScienceDirect
    Cristiana Pistol Tanase, Irina Ogrezeanu, Corin Badiu.
    Pituitary tumor classification : functionality, invasiveness, and aggressiveness -- Immunohistochemistry and electron microscopy as evaluation criteria in tumor classification in the deciphering of pituitary adenomas -- Proliferation -- Angiogenesis -- Apoptosis -- Signal transduction -- Stem cell markers in pituitary adenomas -- MicroRNAs -- New generic tools for diagnosis: genomics and proteomics -- Therapeutic approaches: drug, surgical, and radiotherapy.
  • 2012 Springer Protocols
    edited by Virginia Espina and Lance A. Liotta.
    Tumor staging and grading: A primer -- Clinical trial design in the age of molecular profiling -- Personalized medicine: ethics for clinical trials -- Reduction of preanalytical variability in specimen procurement for molecular profiling -- The human side of cancer biobanking -- Introduction to genomics -- Genomic profiling: cDNA arrays and oligoarrays -- Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples -- An overview of microRNA methods: expression profiling and target identification -- Antibody validation by western blotting -- Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods -- Antibody microarrays: Analysis of cystic fibrosis -- Tissue microarrays as a tool in the discovery and validation of predictive biomarkers -- Reverse-phase protein microarrays -- Serum low-molecular-weight protein fractionation for biomarker discovery -- Mass spectrometry-based biomarker discovery -- Mitochondrial proteome: toward the detection and profiling of disease associated alterations -- Adult neural stem cells: Isolation and propagation -- Evanescent-wave field imaging: An introduction to total internal reflection fluorescence microscopy -- Construction and hyperspectral imaging of quantum dot lysate arrays -- Microarray data analysis: Comparing two population means -- Bioinformatics/biostatistics: microarray analysis -- Structure-based functional design of drugs: From target to lead compound -- Personalized medicine: Changing the paradigm of drug development -- Grant writing tips for translational research -- Inventions and patents: a practical tutorial -- Regulatory approval pathways for molecular diagnostic technology -- Small business development for molecular diagnostics.
  • 2013 Springer
    Liang Cheng, John N. Eble, editors.
    Molecular Pathology of Colorectal Cancer / Fred T. Bosman -- Molecular Pathology of Pancreatic Cancer / Laura D. Wood, N. Volkan Adsay and Ralph H. Hruban -- Molecular Pathology of Liver Tumors / Thomas Longerich, Kai Breuhahn and Peter Schirmacher -- Molecular Pathology of Gallbladder Cancer / Juan Carlos Roa and N. Volkan Adsay -- Molecular Pathology of Lung Cancers / Lynette M. Sholl and Neal I. Lindeman -- Molecular Pathology of Breast Cancer / Alejandro Ariel Gru and Donald Craig Allred -- Molecular Pathology of Ovarian Cancer / Kruti P. Maniar, Ie-Ming Shih and Robert J. Kurman -- Molecular Pathology of Endometrial Cancer / Xavier Matias-Guiu and Jaime Prat -- Molecular Pathology of Kidney Tumors / Sean R. Williamson, John N. Eble and Liang Cheng -- Molecular Pathology of Prostate Cancer / Bora Gurel, Riley E. Alexander, Liang Cheng and Angelo M. De Marzo -- Molecular Pathology of Urinary Bladder Cancer / George J. Netto and Liang Cheng -- Molecular Pathology of Testicular Cancer / Katharina Biermann and Leendert H. J. Looijenga -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer / Andrea Saggini and Boris Bastian -- Molecular Pathology of Head and Neck Cancer / Audrey P. Calzada, Maie A. St. John, Elliot Abemayor and David T. W. Wong -- Molecular Pathology of Soft Tissue and Bone Tumors / Neal I. Lindeman and Paola Dal Cin -- Molecular Pathology of the Central Nervous System / Brent T. Harris and Eyas M. Hattab -- Molecular Pathology of Endocrine Cancer / Ricardo V. Lloyd, Long Jin, Darya Buehler, Heather Hardin and Weihua Shan.
  • 2008 Springer
    edited by Howard L. Kaufman, Scott Wadler, Karen Antman.
  • 2014 Springer
    George M. Yousef, Serge Jothy, editors.
    Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.
  • 2012 Future Med
    editor, Rafael Rosell.
    Integrating molecular knowledge in clinical decision-making for personalized cancer management -- Gastrointestinal stromal tumors -- Metastatic melanoma -- Ovarian cancer -- Triple-negative breast cancer -- Gastric cancer -- Pleural mesothelioma -- Lung adenocarcinoma.
  • 2010 Springer
    Peter J. Houghton, Robert J. Arceci, editors.
    Part 1. Hematologic Malignancies -- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia / William L. Carroll and Rob Pieters -- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia / Alejandro Gutierrez and A. Thomas Look -- Molecularly Targeted Therapy for Infant ALL / Patrick A. Brown and Carolyn A. Felix -- Targeted Therapeutic Approaches for AML / Robert J. Arceci and Donald Small -- Acute Promyelocytic Leukaemia / Andrea Biondi, Anna Maria Testi and Brenda E. S. Gibson -- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy / Jeffrey W. Taub, Yubin Ge and Yaddanapudi Ravindranath -- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML) / Jennifer O'Hara Lauchle and Benjamin S. Braun -- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics / Seth J. Corey and Jorge Cortes -- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes / Lia Gore -- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma / Megan S. Lim and Mitchell S. Cairo -- Molecular Targeting of Post-transplant Lymphoproliferative Disorders / Michael Wang and Thomas G. Gross -- Part 2. Solid Tumors -- Molecularly Targeted Therapies for Astrocytomas / Ian F. Pollack -- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer / Yoon-Jae Cho and Scott L. Pomeroy -- Future Treatments of Ependymoma / Richard J. Gilbertson -- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor / Ganjam V. Kalpana and Melissa E. Smith -- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors / Brigitte Widemann -- Molecular Therapy for Neuroblastoma / Yaël P. Mossé and John M. Maris -- Ewing's Sarcoma Family of Tumors: Molecular Targets Need Arrows / Jeffrey A. Toretsky and Aykut Üren -- Molecular Targeted Therapy for Wilms' Tumor / James I. Geller and Jeffrey S. Dome -- Molecular Therapy for Rhabdomyosarcoma / Raushan T. Kurmasheva, Hajime Hosoi, Ken Kikuchi and Peter J. Houghton -- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here? / Rosanna Ricafort and Richard Gorlick -- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology / Stephen X. Skapek.
  • 2013 Future Med
    editor, Fatih M. Uckun.
    Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • 2013 Future Med
    editor, Jan B. Vermorken.
    Monoclonal antibodies targeting EGFR/HER2 and clinical outcomes in cancer treatment / Jan B. Vermorken -- Colorectal cancer / Christian Rolfo, Giuseppe Bronte, Antonio Russo & Marc Peeters -- Breast cancer / Sevilay Altintas -- Lung cancer and genitourinary cancers / Dirk Schrijvers -- Tumors of the skin, the CNS and the head and neck / Pol Specenier -- Gynecologic cancers / Jan B. Vermorken -- Index.
  • 2013 Springer
    Marie-Odile Parat, editor.
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • 2012 Springer
    Domenico Ribatti.
    Introduction -- Morphological aspects of tumor vasculature -- Mechanisms of control of angiogenesis in tumor vasculature -- Anti-Angiogenesis and vascular targeting in tumor vasculature.
  • 2012 Springer
    Sunil C. Kaul, Renu Wadhwa, editors.
    Part 1. Structure and Function of Mortalin / Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer / Renu Wadhwa and Sunil C. Kaul -- Mortalin's Machinery / Custer C. Deocaris, Sunil C. Kaul and Renu Wadhwa -- The Role of Mortalin in Iron Homeostasis / Wen-I Luo and James A. Cowan -- Functional Characteristics of Mortalin / Walter A. Baseler, Tara L. Croston and John M. Hollander -- Part 2. Mortalin in Evolution2 Deocaris / Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis / Marie Le Pécheur, Geneviève Morrow and Robert M. Tanguay -- Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes / Charles W. Walker, Ben Low and S. Anne Böttger -- Mortalin and Stem Cells: A Study from Planarians / Renata Batistoni -- Part 3. Mortalin in Health and Disease / Mortalin in Cell Protection from Immune Attack / Moran Saar, Oren Moskovich and Zvi Fishelson -- Mortalin in Neurological Diseases / Jinghua Jin, Jing Zhang, Travis J. Cook and Jake G. Hoekstra -- Loss of Mortalin Function in Parkinson's Disease-Supporting the Mitochondrial Pathway of Neurodegeneration / Lena F. Burbulla and Rejko Krüger -- Hsp75/mortalin and Protection from Ischemic Brain Injury / Robin E. White, Yi-Bing Ouyang and Rona G. Giffard -- Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders / Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa and Ram K. Mishra -- Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis / Alberto J. L. Macario, Francesco Cappello and Everly Conway de Macario -- Part 4. Mortalin and Cancer / Many Faces of Mortalin and Tid1 / Ohad Iosefson and Abdussalam Azem -- Mortalin: A Positive Regulator of Centrosome Duplication and Amplification / Masayuki Kanai and Kenji Fukasawa -- Mortalin Expression in Normal and Neoplastic Tissues / Angheliki Nomikos, Sinclair R. Dundas and Graeme I. Murray -- Mortalin-p53 Interaction as a Target for Liver Cancer Therapy / Wen-Jing Lu, Nikki P. Lee, Renu Wadhwa and John M. Luk -- Mortalin Targeting Gadgets for Cancer Therapy / Chae-Ok Yun and Renu Wadhwa -- Part 5. Mortalin Based Technologies / Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term In vitro and In vivo Tracking / Toshimasa Uemura, Masanori Nishi, Sunil C. Kaul and Renu Wadhwa -- Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening / Ran Gao, Zeenia Kaul, Tomoko Yaguchi and Renu Wadhwa -- Cell Internalizing Anti-mortalin Antibody as a Nanocarrier / Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa and Sunil C. Kaul.
  • 2014 Springer
    by Rudolf Happle.
    Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedto the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
  • 2015 Springer Protocols
    edited by Robert Eferl, Emilio Casanova.
    Modeling cancer using genetically engineered mice / Patricia Stiedl ... [and 4 others] -- Lung adenocarcinomas : comparison between mice and men / Helmut H. Popper -- Mouse models of breast cancer / Kazuhito Sakamoto, Jeffrey W. Schmidt, and Kay-Uwe Wagner -- Genetically engineered mouse models to study prostate cancer / Elspeth A. Brzezinska ... [and 3 others] -- Practical use of advanced mouse models for lung cancer / Roghaiyeh Safari and Ralph Meuwissen -- Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations / Johan H. van Es and Hans Clevers -- Induction of colorectal cancer in mice and histomorphometric evaluation of tumors / Ilija Crncec ... [and 3 others] -- Mouse models of liver cancer / Jorge Matias Caviglia and Robert F. Schwabe -- Current methods in mouse models of pancreatic cancer / Pawel K. Mazur ... [and 3 others] -- Mouse models of nonmelanoma skin cancer / Nicole Amberg ... [and 5 others] -- Clinicopathological characterization of mouse models of melanoma / Blake Ferguson, H. Peter Soyer, and Graeme J. Walker -- Modeling BCR/ABL-driven malignancies in the mouse / Christine Schneckenleithner, Andrea Hoelbl-Kovacic, and Veronika Sexl -- Methods to generate genetically engineered mouse models of soft tissue sarcoma / Rebecca D. Dodd ... [and 5 others] -- Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo / Özge Uluçkan, Latifa Bakiri, and Erwin F. Wagner -- Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma / Claudia A. Benavente and Michael A. Dyer -- Tumor imaging technologies in mouse models / Michael Bouvet and Robert M. Hoffman -- Tumor angiogenesis : methods to analyze tumor vasculature and vessel normalization in mouse models of cancer / Federica Maione and Enrico Giraudo -- Transplantable mouse tumor models of breast cancer metastasis / Rumela Chakrabarti and Yibin Kang -- Methods to study primary tumor cells and residual tumor cells in mouse models of oncogene dependence / Caroline Botta ... [and 3 others] -- Generation of transgenic mouse model using PTTG as an oncogene / Sham S. Kakar and Cohin Kakar -- Modeling the study of DNA damage responses in mice / Julia Specks ... [and 3 others] -- Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice / Eva Bauer ... [and 3 others].
  • 2008 Springer
    Shaoguang Li, editor.
  • 2008 Thieme Book
    Steven P. Meyers.
    This book on radiology of musculoskeletal diseases is an aid for the radiologist evaluating problems of the bones, joints, and muscles. Comprehensive differential diagnostic tables are juxtaposed with excellent illustrations from all radiologic modalities. Along with the differential diagnoses, helpful hints for further evaluation or narrowing the diagnosis are provided.
  • 2010 Springer
    Arnd-Oliver Schäfer, Mathias Langer.
  • 2016 Springer
    edited by Monica Mita, Alain Mita, Eric K. Rowinsky.
    This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.
  • 2011 Future Med
    editor, Leonidas C. Platanias.
    mTOR inhibitors in cancer treatment / Leonidas C. Platanias -- Overview and mechanism of action of mTOR inhibitors / Stéphane Oudard -- mTOR inhibitors in renal cell carcinoma / Piotr J. Wysocki -- mTOR inhibitors in hepatocellular carcinoma / Gerhard Treiber & Thomas Wex -- mTOR inhibitors in ovarian cancer / Susana M. Campos -- mTOR inhibitors in breast cancer / Ingrid A. Mayer -- mTOR inhibitors in Hodgkin's and non-Hodgkin's lymphomas / Sonali M. Smith.
  • 2010 Springer
    Vitaly A. Polunovsky, Peter J. Houghton, editors.
    mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
  • 2013 Future Med
    editors, Joyce Taylor-Papadimitriou, Joy M. Burchell.
    Mucins and cancer / Joyce Taylor-Papadimitriou & Joy M. Burchell -- Introduction to mucins in cancer / Michael A. McGuckin -- Changes in mucin-type O-linked glycosylation in cancer / Joy M. Burchell & Joyce Taylor-Papadimitriou -- Mucins as biomarkers in cancer / Kowa Chen, Ola Blixt & Hans H. Wandall -- Signaling from membrane mucins / Tze Wei Poh & Sandra J. Gendler -- MUC4 and membrane receptors in cancer / Kermit L. Carraway & Coralie A. Carothers Carraway -- MUC16, alias CA125 and ovarian cancer / Evangelia-Ourania Fourkala, Aleksandra Gentry-Maharaj & Usha Menon -- Mucins in metastasis / Sylvain Julien -- How mucins shape antigen-presenting cells to modify immune responses / Sandra J. van Vliet & Yvette van Kooyk -- MUC1 as a therapeutic target in cancer / Jean-Marc Limacher & Bruce Acres -- Index.
  • 2014 Springer
    Vincenzo Gentile, Valeria Panebianco, Alessandro Sciarra, editors.
    Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.
  • 2015 Springer
    edited by Gunnar Baatrup.
    This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer (CRC) multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients. Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork. The authors include leading European doctors and scientists who have influenced the development of the multidisciplinary team concept as well as other aspects of high-quality, individualized treatment of CRC patients.
  • 2013 Springer
    Jean-Nicolas Vauthey, Antoine Brouquet, editors.
    It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.
  • 2006 Springer
    J.M. Brown, M.P. Mehta, C. Nieder (eds.) ; with contributions by G-One Ahn ... [et al.].
    Also available: Print – 2006
  • 2016 Springer
    Matthew H.G. Katz, Syed A. Ahmad, editors.
    Anatomic Definitions of Borderline Resectable Pancreatic Cancer -- Imaging Evaluation of Borderline Pancreatic Cancer -- Endoscopic Ultrasonography: Staging and Therapeutic Intervention -- Endoscopic and Percutaneous Biliary Drainage Procedures: Role in Preoperative Management, Diagnosis, and Palliation -- Overview of Multimodality Therapy -- Role of Systemic Therapy -- Role of Radiation Therapy -- Stereotactic Body Radiation Therapy as an Emerging Option for Localized Pancreatic Cancer -- Assessment of Response to Preoperative Therapy -- Emerging Systemic and Targeted Therapies -- Operative Principles in Managing Patients with Borderline Resectable Pancreas Cancer -- Is There a Role for Laparoscopic and/or Robotic Techniques for Borderline Resectable Tumors?. Role and Techniques Of Vascular Resection -- Artery-First Approaches to Pancreaticoduodenectomy -- Venous Shunting Procedures for Borderline Resectable Pancreatic Cancer -- The Role of the Appleby Operation and Arterial Resection in the Multimodality Management of Borderline Resectable Pancreatic Cancer -- Surgery for Borderline Resectable Pancreatic Cancer: The Japanese Experience -- The Role of Irreversible Electroporation and Other Ablative Techniques in Patients with Borderline Resectable Pancreatic Cancer -- Surgical Approach to Borderline Resectable tumors of the Left Pancreas -- Palliative Operations for Unresectable Pancreatic Cancer.
  • 2011 Springer
    Thomas Moehler, Hartmut Goldschmidt, (editors).
    Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
  • 2005 Springer Protocols
    edited by Ross D. Brown, P. Joy Ho.
    Identification of malignant plasma cells by mRNA in situ hybridization / Ross D. Brown and P. Joy Ho -- The SCID-hu myeloma model / Joshua Epstein and Shmuel Yaccoby -- The 5T2MM murine model of multiple myeloma: maintenance and analysis / Karin Vanderkerken ... [et al.] -- Determination of telomerase activity and telomere length / Kai-da Wu and Malcolm A.S. Moore -- Dendritic cell/myeloma hybrid vaccine / Dajing Xia, Tim Chan, and Jim Xiang -- Genetically engineered myeloma cell vaccine / Siguo Hao, Tim Chan, and Jim Xiang -- An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors / Andrew C.W. Zannettino ... [et al.] -- Clonality detection of the expanded T-cell populations in patients with multiple myeloma / Daniel M-Y. Sze -- Detecting mismatch repair defects in myeloma / Mark Velangi ... [et al.] -- Methylation-specific polymerase chain reaction / Oliver Galm and James G. Herman -- Making sense of DNA microarray data / Wei-min Liu, Sunhee K. Ro, and Walter H. Koch. Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz ...
  • 2014 Springer
    Morie A. Gertz, S. Vincent Rajkumar, editors.
    This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.
  • 2009 Springer
    [edited by] Andrea Renda.
  • 2009 Springer
    M.F. Reiser, C.R. Becker, K. Nikolaou, G. Glazer, eds. ; with contributions by H. Alkadhi ... [et al.].
    Also available: Print – 2009
  • 2015 Springer
    Nathan A. Berger, editor.
    This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
  • 2014 Springer
    Swati Palit Deb, Sumitra Deb, editor.
    This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
  • 2006 Springer
    R.N. Eisenmann (ed.).
    Making Myc / J. Liu and D. Levens -- Transcriptional activation by the Myc oncoprotein / M. D. Cole and M. A. Nikiforov -- Mechanisms of transcriptional repression by Myc / D. Kleine-Kohlbrecher, S. Adhikary and M. Eilers -- The mad side of the Max network : antogonizing the function of Myc and more / S. Rottmann and B. Luscher -- Structural aspects of interactions with the Myc/Max/Mad network / S. K. Nair and S. K. Burley -- Myc target transcriptomes / L. A. Lee and C. V. Dang -- c-Myc, genome instability, and tumorigenesis : the devil is in the details / M. Wade and G. M. Wahl -- Lessons learned from Myc/Max/Mad knockout mice / M. Pirity, J. K. Blanck and N. Schreiber-Agus -- Myc/Max/Mad in invertebrates : the evolution of the Max network / P. Gallant -- The mix network : evidence for a parallel Max-like transcriptional network that regulates energy metabolism / A. N. Billin and D. E. Ayer.
    Also available: Print – 2006
  • 2013 Springer
    [edited by] H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer.
    Part I. Epidemiology and clinical presentation -- Clinical presentation and differential diagnosis -- Epidemiology and etiology -- Part II. Pathology, pathophysiology and staging -- Cytogenetic diagnosis of myelodysplastic syndromes -- MDS stem cell biology -- The biology of myelodysplastic syndrome associated with Isolated del(5q) -- A personalized molecular pathogenesis of MDS -- Myelodysplastic/myeloproliferative neoplasms -- Classification and staging of myelodysplastic syndromes -- Immunophenotyping in myelodysplastic syndromes -- Prognostic models for patients with myelodysplastic syndromes -- Part III. Treatment -- Management of low-risk MIDS -- Management of high-risk myelodysplastic syndrome -- Hematopoietic cell transplantation (HCT) -- Part IV. MIDS in children -- Myelodysplastic syndrome in children.
  • 2005 Springer Protocols
    edited by Harry Iland, Mark Hertzberg, Paula Marlton.
    Diagnosis and monitoring of AML1-MTG8 (ETO)-positive acute myeloid leukemia by qualitative and real-time quantitative RT-PCR / Khalid Tobal and John A. Liu Yin -- Diagnosis and monitoring of CBFB-MYH11-positive acute myeloid leukemia by qualitative and quantitative RT-PCR / Bert A. van der Reijden and Joop H. Jansen -- Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia / Jan Cools, Elizabeth H. Stover, and D. Gary Gilliland -- FLT3 mutations in acute myeloid leukemia / Hitoshi Kiyoi and Tomoki Naoe -- WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes / Daniela Cilloni, Enrico Gottardi, and Giuseppe Saglio -- Classification of AML by DNA-oligonucleotide microarrays / Alexander Kohlmann ... [et al.] -- Classification of AML using a monoclonal antibody microarray / Richard I. Christopherson ... [et al.] -- Isolation of RNA and DNA from leukocytes and cDNA synthesis / Joop H. Jansen and Bert A. van der Reijden -- Cytogenetics and FISH techniques in myeloid malignancies / Lynda J. Campbell -- Overview of real-time RT-PCR strategies for quantification of gene rearrangements in the myeloid malignancies / Christophe Picard, Monique Silvy, and Jean Gabert -- Diagnosis and monitoring of chronic myeloid leukemia by qualtitative and quantitative RT-PCR / Susan Branford and Timothy Hughes -- Detection of BCR-ABL mutations and resistance to imatinib mesylate / Susan Branford and Timothy Hughes -- Deletion of the derivative chromosome 9 in chronic myeloid leukemia / Lynda J. Campbell -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR / Vincenzo Rossi, Laura Levati, and Andrea Biondi -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by quantitative RT-PCR / Elisa Mokany ... [et al.] -- Methods for the detection of the JAK2 V617F mutation in human myeloproliferative disorders / Peter J. Campbell ... [et al.] -- Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia / Maurizio Martini, Luciana Teofili, and Luigi M. Larocca -- Chimerism analysis following nonmyeloablative stem cell transplantation / Thomas Lion and Franz Watzinger.
  • 2010 Springer
    edited by G. David Roodman.
    Clinical Presentation of Myeloma Bone Disease / Rebecca Silbermann and G. David Roodman -- Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias / Ronald C. Walker, Laurie Jones-Jackson, Twyla Bartel, Tracy Brown and Bart Barlogie -- Biochemical Markers of Bone Remodeling in Multiple Myeloma / Evangelos Terpos -- Radiation Therapy in Multiple Myeloma / Joel S. Greenberger -- Surgical Management of Bone Disease / Mohamad A. Hussein -- Bisphosphonates in the Treatment of Myeloma Bone Disease / James R. Berenson -- Osteonecrosis of the Jaw / Ashraf Badros -- Murine Models of Myeloma Bone Disease: The Importance of Choice / Peter I. Croucher, Karin Vanderkerken, Joshua Epstein and Babatunde Oyajobi -- RANK Ligand Is a Therapeutic Target in Multiple Myeloma / William C. Dougall, Michelle Chaisson-Blake, Howard Yeh and Susie Jun -- Osteoclast Activation in Multiple Myeloma / Sonia Vallet and Noopur Raje -- Potential Role of IMiDs and Other Agents as Therapy for Myeloma Bone Disease / Suzanne Lentzsch -- Proteasome Inhibitors and the Wnt Signaling Pathway in Myeloma Bone Disease / Claire M. Edwards and Gregory R. Mundy -- Mechanisms Involved in Osteoblast Suppression in Multiple Myeloma / Nicola Giuliani.
  • 2014 Cambridge
    edited by Stephen A. Schey, Professor of Plasma Cell Dyscrasias, King's College London ; Consultant Haematologist, King's College Hospital NHS Foundation Trust, London, UK, Kwee L. Yong, Professor of Haematology, University College London ; Consultant Haematologist, University College London Hospitals, London, UK, Robert Marcus, Consultant Haematologist, King's College Hospital NHS Foundation Trust, London, UK, Kenneth C. Anderson, Kraft Family Professor of Medicine, Harvard Medical School, Medical Director, Kraft Family Blood Donor Center, Dana-Faber Cancer Institute, Boston, MA, USA.
    Epidemiology of myeloma / Eve Roman and Alexandra G. Smith -- Diagnosis and immunophenotyping of myeloma / Roger Owen -- Imaging of myeloma / Nicola Mulholland and Ming Wan -- Cell cycle regulation and myeloma precursor cells / John Quinn and Kwee L. Yong -- The genetic and epigenetic mechanisms underlying the behaviour of myeloma / Martin F. Kaiser, Kevin D. Boyd, and Gareth J. Morgan -- The myeloma bone marrow environment and survival signaling / Kwee L. Yong, John Quinn, and Asim Khwaja -- Immune dysfunction in multiple myeloma / Guy Pratt and Paul Moss -- Myeloma bone disease : pathogenesis of bone destruction and therapeutic strategies / Andrew Chantry and Neil Rabin -- Principles of pathway directed therapy for myeloma / Yu-Tzu Tai and Kenneth C. Anderson -- Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma / Efstathios Kastritis and Meletios A. Dimopoulos -- Multiple myeloma : management of de novo disease / T. Guglielmelli, P. Sonneveld, A. Broyl, and Antonio Palumbo -- Treatment of relapsed/refractory myeloma / Matthew J. Streetly, Jacob Laubach, Paul Richardson, and Stephen A. Schey -- Solitary bone and extramedullary plasmacytoma / Shirley Sa -- Amyloidosis / Ashutosh D. Wechalekar, Simon W. Dubrey, and Raymond L. Comenzo -- Waldenstrom's macroglobinemia/lymphoplasmocytic lymphoma / Steven P. Treon and Giampaolo Merlini -- Castleman's disease / Karthik Ramasamy -- Poems syndrome and paraproteinaemic syndromes : management and follow-up / Angela Dispenzieri and Suzanne R. Hayman -- Treatment of emergent peripheral neuropathy and plasma cell disorders / Charise Gleason, Melanie Watson, and Sagar Lonial -- Management of renal failure in multiple myeloma / Aneel Paulus, Pooja Advani, Nabeel Aslam, and Asher Alban Chanan-Khan -- The management of infection in myeloma / Christopher P. Conlon.
  • 2012 Springer
    Tiziano Barbui, Ayalew Tefferi, editors.
    Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs. This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
  • 2011 Springer
    edited by Srdan Verstovsek, Ayalew Tefferi.
    Diagnosis and classification of the BCR-ABL1-negative myeloproliferative neoplasms -- Genetics of the myeloproliferative neoplasms -- Cytogenetic findings in classical MPNs -- Prognostic factors in classic myeloproliferative neoplasms -- Therapy of polycythemia vera and essential thrombocythemia -- Conventional and investigational therapy for primary myelofibrosis -- Hematopoietic cell transplantation for myelofibrosis -- JAK2 inhibitors for therapy of myeloproliferative neoplasms -- Blastic transformation of classic myeloproliferative neoplasms -- Eosinophilic disorders: differential diagnosis and management -- Pathogenesis, diagnosis, classification, and management of systemic mastocytosis.
  • 2012 CRCnetBASE
    editors, Rajaventhan Srirajaskanthan, Victor R. Preedy.
    Nanomedicine-based use of sirna in cancer / Guillermo N. Armaiz-Pena ... [et al.] -- Nanocarriers for gene delivery / Conchita Tros de Ilarduya and Gloria Gonzalez-Aseguinolaza -- Cancer cell photothermolysis and gold nanorod surface plasmons / Cheng-Lung Chen and Yang-Yuan Chen -- Tocotrienol loaded lipid nanoparticles in cancer / Sami Nazzal and Paul W. Sylvester -- Utilization of magnetic nanoparticles for cancer therapy / Deryl L. Troyer and Stefan H. Bossmann -- Nanoparticle probes and molecular imaging in cancer / Dongfang Liu and Ning Gu -- Iron and ethylcellulose nanoplatforms for cancer targeting / José L. Arias, Margarita López-Viota, and Ma Adolfina Ruiz -- Matrix scaffolds in cancer cell biology, physiological representation and nanoscale characterisation / Hsin-ya Chien ... [et al.] -- Fluorescence nanoprobe imaging tumor by sensing the acidic microenvironment / Lu Wang and Cong Li -- Magnetic nanorings and nanotubes for cancer detection and therapy / Hai Ming Fan and Malini Olivo -- Silicon nanowire arrays and other silicon nanostructures and their clinical applications to cancer / Murugan Veerapandian and Min-Ho Lee -- Silver nanomedicine and cancer / ... [et al.] -- Nanobubbles and their putative application to cancer medicine / Tianyi M. Krupka and Agata A. Exner -- Nano-strategies in the delivery of antitumor drugs to cancer / José L. Arias -- Gene silencing with sirna encapsulated nanoparticles to overcome tumor multidrug resistance / Mansoor M. Amiji, Francis Hornicek, and Zhenfeng Duan -- Nano-flow liquid chromatography mass spectrometric analysis of glycans in cancer / S. Hunter Walker and David C. Muddiman -- Composite nano-sensor arrays technology in lung cancer / Silvano Dragonieri, Giorgio Pennazza, and Marco Santonico -- Nano arsenic oxide (As2o3)/(Fe2o3) iron oxide complexes for liver cancer / Ziyu Wang and Dongsheng Zhang -- Hepatocellular carcinoma and midkine-antisense oligonucleotide-loaded nanoparticles / Licheng Dai, Yaoxing and Zhongjing -- Nanotechnology and nanostructures applied to head and neck cancer / Erik C. Dreaden, Mostafa A. El-Sayed, and Ivan H. El-Sayed.
  • 2007 CRCnetBASE
    edited by Mansoor M. Amiji.
  • 2015 Springer
    Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh, editors.
    Nanoflares as Probes for Cancer Diagnostics -- Therapeutic Applications of Spherical Nucleic Acids -- Theranostic Magnetic Nanostructures (MNS) for Cancer -- Nanodiamond-Based Chemotherapy and Imaging -- Theranostic Lipid Nanoparticles for Cancer Medicine -- Synthetic High-Density Lipoprotein-Like Nanoparticles as Cancer Therapy -- Radiosensitization and Nanoparticles -- Hybrid Nanoparticles for Cancer Imaging and Therapy -- Exploring Tumor Microenvironment with Nanoparticles -- How nanoparticles interact with cancer cells -- Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics -- Calibration-Quality Cancer Nano-Therapeutics -- Cancer Nano-Therapeutics in Clinical Trials.
    Also available: Print – 2015
  • 2013 Springer
    edited by Pierre Busson.
    Diagnosis and clinical evaluation of nasopharyngeal carcinoma / Alan Soo-Beng Khoo and Kin-Choo Pua -- Histopathological diagnosis of nasopharyngeal carcinoma : looking beyond the blue book / John Nicholls and Gerald Niedobitek -- Descriptive, environmental and genetic epidemiology of nasopharyngeal carcinoma/ -- Bing-jian feng -- Epstein-Barr virus and the pathogenesis of nasopharyngeal carcinomas / Claire Gourzones, Pierre Busson and Nancy Raab-Traub -- Acquired genetic and epigenetic alterations in nasopharyngeal carcinoma / Kwok-Wai Lo, Grace Tin-Yun Chung and Ka-Fai To -- Cellular interactions in nasopharyngeal carcinomas / Claire Gourzones ... [et al.] -- Biological tools for NPC population screening and disease monitoring / Claire Gourzones ... [et al.] -- Medical imaging of nasopharyngeal carcinomas : current tools and applications / François Bidault -- Radiotherapy of NPC : current strategies and perspectives / John Kim -- The evolving role of systemic therapy in nasopharyngeal carcinoma : current strategies and perspectives / Edwin P. Hui and Anthony T.C. Chan -- Nasopharyngeal carcinoma immunotherapy current strategies and perspectives / Corey Smith and Rajiv Khanna -- Therapeutic induction of apoptosis in nasopharyngeal carcinoma / Carlo Bastianutto ... [et al.].
    Also available: Print – 2013
  • 2010 NAP
    Committee on Cancer Clinical Trials and the NCI Cooperative Group Program, Board on Health Care Services.
    Introduction -- The science of developing cancer therapy -- Operations, oversight, and funding of cancer clinical trials -- Physician and patient participation in cancer clinical trials.
  • 2012 Springer
    Masaki Terabe, Jay A. Berzofsky, editors.
    Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi ... [et al.] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes ... [et al.] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders ... [et al.] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
  • 2013 Springer
    Frank E. Koehn, editor.
    Part 1. Natural Product Drugs and Cancer Therapeutics -- The Impact of Natural Products Upon Cancer Chemotherapy / A. Ganesan -- Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth / Andrea T. Hooper, Frank Loganzo, Chad May and Hans-Peter Gerber -- Discodermolide: Past, Present, and Future / Ross E. Longley -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents / Lilibeth A. Salvador and Hendrik Luesch -- Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates / Frank E. Koehn -- Part 2. Advances in Natural Product Cancer Drug Discovery -- Natural Product Scaffolds in Cancer Therapy / Christian P. Mang and Lars Ole Haustedt -- The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery / Claudia Eva-Maria Unsin, Scott R. Rajski and Ben Shen -- Accessing Anti-cancer Natural Products by Plant Cell Culture / Lisa M. Leone and Susan C. Roberts -- Natural Products as Tools for Discovering New Cancer Targets / John A. Beutler.
  • 2014 Future Med
    editors, Mario Campone, Jean-Sébastien Frenel.
    Neoadjuvant therapy in breast cancer / Mario Campone & Jean-Sébastien Frenel -- Ask the experts : neoadjuvant therapy : current options / Mark Beresford -- Evaluation of complete pathologic response / Audrey Mailliez, Géraldine Lauridant-Philippin & Jacques M Bonneterre -- Recommendation and predictors of pathologic response / Vladimir F. Semiglazov & Vladislav V. Semiglazov -- Combination chemotherapy and targeted agents / Victoria Brown & Stephen Chan -- Role of radiation after neoadjuvant chemotherapy / Michelle A. Kraay & Janice A. Lyons -- Monoclonal antibody therapy / Jean-Sébastien Frenel & Mario Campone -- Multiple choice questions : answers.
  • 2013 Springer
    Peter H. Wiernik, Janice P. Dutcher, John M. Goldman, Robert A. Kyle, editors.
    Neoplastic Diseases of the Blood" integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia - Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.
  • 2005 Springer
    Nai-Kong V. Cheung, Susan L. Cohn, (eds).
    Also available: Print – 2005
  • 2012 Springer
    edited by M.A. Hayat.
  • 2011 Springer
    James C. Yao, Paulo M. Hoff, Ana O. Hoff, editors.
    Global epidemiology of neuroendocrine tumors -- Pathology -- Multiple endocrine neoplasia -- Other genetic syndromes -- Imaging of neuroendocrine tumors -- Surgical management of sporadic gastrointestinal neuroendocrine tumors -- Management of neuroendocrine tumor hormonal syndromes -- Management of metastatic carcinoid tumors -- Medical management of islet cell carcinoma -- Poorly differentiated neuroendocrine tumors -- Hereditary and sporadic medullary thyroid carcinoma -- Adrenocortical carcinoma -- Pheochromocytoma -- Merkel cell carcinoma.
  • 2015 Karger
    volume editors, Mauro Papotti, Wouter W. de Herder.
    Epidemiology of neuroendocrine tumors / Fraenkel, M.; Faggiano, A. ; Valk, G.D. -- Biochemical testing in patients with neuroendocrine tumors / Granberg, D. -- Clinical syndromes related to gastrointestinal neuroendocrine neoplasms / Boutzios, G.; Kaltsas, G. -- Radiological imaging : computed tomography, magnetic resonance imaging and ultrasonography / Sundin, A.; Wills, M.; Rockall, A. -- Nuclear medicine imaging of neuroendocrine tumors / Brabander, T.; Kwekkeboom, D.J.; Feelders, R.A.; Brouwers, A.H.; Teunissen, J.J.M. -- Endoscopy and endoscopic ultrasound in assessing and managing neuroendocrine neoplasms / O'Toole, D.; Palazzo, L -- Pathology : classification and immunoprofile / Blank, A.; Schmitt, A.; Perren, A. -- Genetics and epigenetics of pancreatic neuroendocrine tumors and pulmonary carcinoids / Dreijerink, K.M.A.; Derks, J.L.; Cataldo, I.; Scarpa, A.; Valk, G.D.; Speel, E.-J.M. -- Pancreatic surgery / Maurizi, A.; Partelli, S.; Falconi, M. -- Gastrointestinal surgery of neuroendocrine neoplasms / Palns Hansen, C.; Holst Olsen, I.; Knigge, U. -- Transplantation and debulking procedures for neuroendocrine tumors / Frilling, A.; Al-Nahhas, A.; Clift, A.K. -- A 25-year experience of gastroenteropancreatic neuroendocrine tumors and somatostatin (congeners) analogs : from symptom control to antineoplastic therapy / O'Dorisio, T.M. ; Anthony, L.B. -- Medical therapy of pulmonary neuroendocrine neoplasms : targeted, symptomatic and chemotherapy / Ferolla, P. -- Peptide receptor radionuclide therapy of neuroendocrine tumors / Bodei, L.; Kidd, M.; Prasad, V.; Modlin, I.M. -- Hormone and receptor candidates for target and biotherapy of neuroendocrine tumors / Hofland, L.J.; Vandamme, T.; Albertelli, M.; Ferone, D. -- The role of chemotherapy in well-differentiated gastroenteropancreatic neuroendocrine tumors / Strosberg, J.; Goldman, J.; Costa, F.; Pavel, M. -- Other novel therapies : biomarkers, microRNAs and microRNA inhibitors, DNA methylation, epigenetics, immunotherapy and virotherapy / Giandomenico, V.; Thirlwell, C.; Essand, M.
  • 2015 Springer
    Suayib Yalcin, Kjell Öberg, editors.
  • 2008 Karger
    volume editor, Dieter Kaufmann.
    The neurofibromatoses: classification, clinical features, and genetic counselling / S.M. Huson -- Treatment and management of neurofibromatosis 1 / V.F. Mautner, E. Boltshauser -- Neurofibromatosis type 1 and other syndromes of the Ras pathway / D.A. Stevenson, J.J. Swensen, D.H. Viskochil -- NF1 gene structure and NF1 genotype/phenotype correlations / M. Upadhyaya -- NF1 mutational spectrum / L.M. Messiaen, K. Wimmer -- Clinical phenotypes in patients with NF1 microdeletions / S. Tinschert -- Structure of the NF1 gene region and mechanisms underlying gross NF1 deletions / H. Kehrer-Sawatzki -- NF1 gene evolution in mammals / G. Assum, C. Schmegner -- Structure and function of neurofibromin / S. Welti, I. D'Angelo, K. Scheffzek -- Composition of neurofibromas, NF1 expression, and comparison of normal and NF1 haploinsufficient cells / J. Peltonen, S. Peltonen -- Somatic NF1 mutations in tumors and other tissues / T. De Raedt ... [et al.] -- NF2: mutations and management of disease / D.G.R. Evans, A. Wallace -- Function of merlin in genesis of tumours and other symptoms of NF2 / C.O. Hanemann -- Molecular studies on schwannomatosis / L. Kluwe.
  • 2011 Springer
    Rosalie E. Ferner, Susan M. Huson, D. Gareth R. Evans.
    Neurofibromatosis 1 -- Neurofibromatosis Type 2 (NF2) -- The Neurofibromatoses: Differential Diagnosis and Rare Subtypes -- Psychological Impact of the Neurofibromatoses -- Clinical Quiz: Diagnostic and Management Pitfalls of Neurocutaneous Disease.
  • 2012 Springer
    Meena Upadhyaya, David N. Cooper, editors.
    Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.Neurofibromatosis Type 1: Molecular and Cellular Biology will be of great value to medical geneticists, molecular and cellular biologists, oncologists, dermatologists, neurologists, genetic counsellors and general practitioners alike.
  • 2007 Karger
    volume editors, Kurt S. Zänker, Frank Entschladen.
    Neuronal development / K.M. Giehl -- Organization of peripheral nerves in skin, musculoskeletal system, and viscera / M. von Düring, B. Fricke -- Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis / H.M. Schuller -- Neuronal markers in non-neuronal tissues / C. Hagel, D. Stavrou -- Chemotropic axon guidance molecules in tumorigenesis / A. Chédotal -- Neoneurogenesis and the neuro-neoplastic synapse / D. Palm, F. Entschladen -- Neurotransmitter effects on tumor cells and leukocytes / K. Lang, P. Bastian -- Stem cells and neurogenesis in tumors / J.A. Varner -- Potential inhibition of the neuro-neoplastic interactions: the clue of a GPCR-targeted therapy / J.-M. Muller -- The neuro-neoplastic synapse: does it exist? / K.S. Zänker.
  • 2006 Springer
    [edited by] J.-C. Tonn ... [et al.].
  • pt. I-II, 2012. ScienceDirect
    pt. II ScienceDirect
    volume editors, Wolfgang Grisold and Riccardo Soffietti.
  • 2015 Thieme eNeurosurgery
    [edited by] Mark Bernstein, Mitchel S. Berger.
  • 2005 Thieme eNeurosurgery
    editor, Shigeaki Kobayashi ; assistant editor, Keiichi Sakai.
  • 2007 Thieme eNeurosurgery
    [edited by] Behnam Badie.
    Transsphenoidal approaches to the sella and suprasellar region -- Surgical approaches to craniopharyngiomas -- Eyebrow orbitotomy approach to parasellar tumors -- Expanded endonasal approach to the sella and anterior skull base -- Endoscopic approaches for intraventricular brain tumors -- Surgical approaches to tumors of the third ventricle -- Surgical approaches to intraventricular tumors (lateral ventricles) -- Surgical management of spinal meningiomas -- Surgical management of spinal metastatic tumors: the anterior lumbar approach and the lateral retroperitoneal approach to the thoracolumbar spine -- Surgical management of peripheral nerve tumors -- Surgical management of spinal schwannomas -- Balloon-catheter brachytherapy for malignant brain tumors -- Intraoperative magnetic resonance imaging for brain tumor resection -- Stereotactic resection of malignant brain tumors -- Radiosurgery of intracranial lesions -- Surgical management of meningiomas of the sphenoid wing region: operative approaches to medial and lateral sphenoid wing, spheno-orbital, and cavernous sinus meningiomas -- Surgical management of convexity meningiomas -- Surgical technique for removal of clinoidal meningiomas -- Surgical management of olfactory groove meningiomas -- Petrosal approach for resection of petroclival meningiomas -- Surgical management of tentorial meningiomas -- Surgical management of tuberculum sellae meningiomas -- Surgical management of jugular foramen schwannomas -- Surgical approaches to pineal region tumors -- Surgical approaches to pediatric midline posterior fossa tumors -- Surgical approaches to vestibular schwannomas -- Surgical resection of lower clivus-anterior foramen magnum meningiomas -- Surgical management of trigeminal neuroinomas -- Surgical management of intracranial glomus tumors -- Preauricular transzygomatic subtemporal and infratemporal approaches to the skull base -- Combined craniofacial resection of anterior skull base tumors -- Surgical resection of esthesioneuroblastoma -- Transmaxillary approaches to the clivus -- Surgical management of cholesterol granulomas of the petrous apex -- Transbasal approaches to the skull base and extensions -- Transmandibular approaches to the skull base.
  • 2012 Springer
    Wolfgang A.G. Sauerwein [and others], editors.
    Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter. This in principle allows for tumor cell-selective high-LET particle radiotherapy. NCT is exciting scientifically but challenging clinically, and a key factor in success is close collaboration among very different disciplines. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
  • 2012 Springer
    Ashfaq A. Marghoob, editor.
    Nevogenesis: Changing Theories -- Classifying Melanocytic Nevi -- Evolution of Nevi -- The Dual Pathway of Nevogenesis -- Confocal Microscopy: Improving Our Understanding of Nevogenesis -- Nevi In Children And Adults: Dermoscopic Patterns And The Development of New Nevi -- Etiology of Congenital Melanocytic Nevi And Related Conditions -- Molecular Nevogenesis -- Nevogenesis: A Benign Metastatic Process? -- Nevus Senescence -- Gene-Environment Interactions In Nevogenesis -- Malignant Transformation of Melanocytic Nevi -- Disappearance of Melanocytic Nevi.
  • 2013 Springer
    Nikki P. Lee, C.Y. Cheng, John M. Luk, editors.
    Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
  • 2011 Springer
    Vaskar Saha, Pamela Kearns, editors.
  • 2013 Springer
    Antonella Surbone, Matjaž Zwitter, Mirjana Rajer, Richard Stiefel, editors.
    The relationship between oncologists and their cancer patients is rapidly evolving. Oncologists and other cancer professionals master new anticancer and supportive treatment options, while working under increasing economic pressure and time constraints, and are often unprepared to deal with all the challenges of their new position in a therapeutic relationship with cancer patients and families. Good communication is as essential as are modern laboratory tests and sophisticated diagnostics to achieve the best clinical results. This book updates the evolution of truth-telling and communication patterns worldwide and offers insights into the recent trends and emerging challenges in communication with cancer patients and families. New Challenges in Communication with Cancer Patients is an invaluable resource to medical professionals, educators and patients in establishing a strong and effective partnership built on trust and mutual understanding.
  • 2011 Springer
    Andrea Laghi (ed.) ; foreword by Albert L. Baert.
    Epidemiology, clinical aspects and pathology -- Epidemiology, risk factors and clinical presentation -- Pathology and genetics -- Diagnosis -- Ultrasound -- Case for MDCT -- Case for MRI -- Endoscopic ultrasonography in pancreatic tumors: when and why? -- PET/CT in pancreatic cancer -- Cost decision analysis for diagnosing and staging -- Therapy -- Case for surgery -- Locally advanced nonmetastatic cancer -- Metastatic pancreatic cancer: systemic therapy -- Role of interventional endoscopy -- Local ablative techniques in the treatment of locally advanced pancreatic cancer.
  • 2006 Springer
    W. Schlegel, T. Bortfeld, A.-L. Grosu (eds.) ; with contributions by J.R. Adler ... [et al.] ; foreword by L.W. Brady, H.-P. Heilmann, and M. Molls.
    Also available: Print – 2006
  • 2010 Springer
    Antonio Mussa (ed.) ; foreword by Enrico De Antoni.
  • 2015 Springer
    Solange Peters, Benjamin Besse, editor.
    This book provides an up-to-date review of current management techniques for Non-Small Cell Lung Cancer. It addresses all of the latest issues that have been raised by the discovery of oncogenic drivers and the improvement of diagnosis and therapeutic methods, including new radiotherapy techniques and anticancer strategies like immunotherapy. New strategies for patients with molecular alterations and the management of particular types of cases are also highlighted. Written by recognized experts in their field, the book represents a unique and valuable resource in the field of lung cancer, both for those currently in training and for those already in clinical or research practice.
  • 2006 Springer
    edited by Antonio Llombart-Bosch, Vicente Felipo, and José Antonio López-Guerrero.
    Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS) / P. Picci ... [et al.] -- Targeted therapies in Ewing's sarcoma / K. Scotlandi -- The CCN3 protein and cancer / B. Perbal -- EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage / J. Ban ... [et al.] -- Molecular karyotyping in sarcoma diagnostics and research / H. Vauhkonen ... [et al] -- TuBaFrost: European virtual tumor tissue banking / P.H.J. Riegman ... [et al] -- Virtual microscopy in virtual tumor banking / M. Isabelle ... [et al] -- Harmonizing cancer control in Europe / U. Ringborg -- The diagnosis of cancer: from H&E to molecular diagnosis and back / J. Costa -- From morphological to molecular diagnosis of soft tissue tumors / M. Miettinen -- Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract / H. Höfler ... [et al] -- Integrating the diagnosis of childhood malignancies / D. López-Terrada -- Preclinical models for cell cycle-targeted therapies / M. Malumbres -- WWOX, a chromosomal fragile site gene and its role in cancer / D. Ramos and C.M. Aldaz -- From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis / J.K. Habermann ... [et al] -- Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models / L. Holmquist, T. Löfstedt, and S. Påhlman -- Methylation patterns and chemosensitivity in NSCLC / J.L. Ramírez ... [et al] -- Pharmacogenomics and colorectal cancer / H.J. Lenz -- Development of pharmacogenomic predictors for preoperative chemotherapy of breast cancer / L. Pusztai -- Vascular endothelial growth factor inhibitors in colon cancer / E. Díaz-Rubio -- Molecular imaging of cancer using PET and SPECT / A. Kjær -- MRS as endogenous molecular imaging for brain and prostate tumors: FP6 project "eTUMOR" / B. Celda ... [et al] -- From Linac to tomotherapy: new possibilities for cure? / G. Storme ... [et al] -- Targeting mTOR for cancer treatment / B. Rubio-Viqueira and M. Hidalgo -- Dual/pan-her tyrosine kinase inhibitors: focus in breast cancer / J. Albanell -- Antitumor-associated antigens IGGS: dual positive and negative potential effects for cancer therapy / E. Barberá Guillem and J.W. Sampsel -- Synergistic molecular mechanisms in hormone-sensitive breast cancer / A. Llombart Cussac.
    Also available: Print – 2006
  • 2009 Springer
    T. Tachikawa, K. Nose, T. Ohmori, M. Adachi, (eds.).
  • 2013 Springer
    Wei Wu, Hani Choudhry, editors.
    Introduction: next generation sequencing technology and cancer research -- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is dark matter unannotated RNA -- Total RNA-seq of breast cancer in hypoxia -- Altered antisense-to-sense transcript ratios in breast cancer -- Identification of piRNAs in Hela cells by massive parallel sequencing -- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia -- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome -- Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma -- Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing -- Tumour evolution inferred by single-cell sequencing -- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq -- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis -- Whole genome DNA methylation analysis based on high throughput sequencing technology -- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors -- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq -- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action -- Genome-wide identification of polycomb-associated RNAs by RIP-seq -- Single-molecule sequencing: sequence methods to enable accurate quantisation -- Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells -- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA -- The genome information process for cancer research: the challenge and perspective.
  • 2013 Springer
    Alberta Ferrari, Adele Sgarella, Sandro Zonta, Editors ; foreword by Virgilio Sacchini.
    This book describes in detail three different techniques for minimally invasive video-assisted breast surgery: nipple-sparing mastectomy with a hand-held external retractor, with a single-port device, and with robotic assistance. All three techniques can be employed for radical treatment of breast cancer or for risk reduction surgery, and the last two are brand new. The techniques are clearly explained with the aid of numerous high-quality illustrations. All surgical stages are covered in detail, and helpful information is provided on key aspects of surgical anatomy, diagnostic workup, instrumentation, and postoperative management. Nipple Sparing Mastectomy is the first manual to cover these techniques, which are likely to become standard in the field of oncological breast surgery. It will be invaluable for breast surgeons who are skilled in nipple-sparing mastectomy and oncoplastic techniques or are working in breast units that offer genetic counseling to high-risk patients.
  • 2010 Springer
    Benjamin Bonavida, editor.
    Nitric oxide and cancer: an overview -- A role for eNOS in oncogenic Ras-driven cancer -- Dual role of nitric oxide in cancer biology -- Nitric oxide expression in cancer -- S-nitrosylation: how cancer cells say NO to cell death -- Cytotoxic and protective activity of nitric oxide in cancers -- Cytotoxic/protective activity of nitric oxide in cancer -- Nitric oxide and life or death of human leukemia cells -- Inhibition of apoptosis by endogenous nitric oxide in chronic lymphocytic leukaemia -- Nitric oxide: a rate-limiting factor for metastases development -- Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB/Snail/RKIP loop -- Sensitizing effect of nitric oxide to cytotoxic stimuli -- Nitric oxide is a promising enhancer for cancer therapy -- Role of nitric oxide for modulation of cancer therapy resistance -- Breaking resistance: role of nitric oxide in the sensitization of cancer cells to chemo- and immunotherapy -- Prognostic significance of iNOS in human melanoma -- Prognostic significance of iNOS in hepatocellular carcinoma -- Prognostic significance of iNOS in esophageal cancer -- Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis -- Nitric oxide-releasing molecules for cancer therapy and chemoprevention -- Nitric oxide: monotherapy or sensitiser to conventional cancer treatments? -- Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies -- (S, R)-3-Pheynyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO): new dress for nitric oxide mission -- Nitric oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis -- Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of nitric oxide of HIF-1a: potential role of Se-Methylselenocysteine(MSC), an antioxidant multi-targeted small molecule.
  • 2014 Springer
    Muller Fabbri, editor.
    Introduction / Muller Gabbri -- Biogenesis and physiology of microRNAs / Carlos A. Melo and Sonia A. Melo -- Detecting noncoding RNA expression : from arrays to next-generation sequencing / Catalina Perdomo, Joshua Campbell, and Frank Schembri -- MicroRNAs in solid tumors / Jin Wang and Subrata Sen -- MicroRNAs in hematologic malignancies / Johannes Bloehdorn ... [et al.] -- miRNAs as cancer biomarkers / Edward R. Sauter -- Unraveling the complex network of interactions between noncoding RNAs and epigenetics in cancer / Veronica Davalos and Manel Esteller -- MicroRNA SNPs in cancer / Yujing LI and Peng Jin -- Bioinformatics approaches to the study of MircoRNAs / Ravi Gupta and Ramana V. Davuluri -- Beyond miRNAs : role of other noncoding RNAs in cancer / Roxana S. Redis and George A. Calin -- Translational implication for noncoding RNA in cancer / Duaa Dakhallah, Melissa Piper, and S. Patrick Nana-Sinkam.
  • 2015 Springer
    Isidoro Di Carlo, editor ; foreword by Masatoshi Makuuchi.
    This book offers a complete overview on noncolorectal nonneuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history, and diagnosis. NCRNNE metastases to the liver are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy, and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.
  • 2013 Springer
    Peter J. Quesenberry, Jorge J. Castillo, editors.
    Biology -- Cancer Stem Cells: A Matter of Perspective / Peter J. Quesenberry, J. Reagan, B. Ramratnam, L. Goldberg -- B and T Cell Development / Loren D. Fast -- HIV Lymphomagenesis / Liron Pantanowitz, Antonino Carbone -- Epstein-Barr Virus Lymphomagenesis and Therapeutic Targets / Huilan Rao, Roberto N. Miranda -- Antigen-Driven Lymphomagenesis / Reve Shields, James N. Butera -- Preclinical Modeling in Lymphoid Malignancies / Richa Dawar, Francisco J. Hernandez-Ilizaliturri -- Prognostic Factors -- Prognostic Factors in B-Cell Lymphomas / Diana O. Treaba, Diana O. Treaba -- Prognostic Factors in Peripheral T-Cell Lymphomas / Brady E. Beltran, Jorge J. Castillo -- Prognostic Factors in HIV-Associated Lymphoma / Jodi L. Layton, Jorge J. Castillo -- Therapy -- Future Directions in Aggressive Lymphomas / Guilherme F. Perini, Luis E. Fayad -- New Monoclonal Antibodies for Indolent Non-Hodgkin Lymphoma / Tadeusz Robak -- Current Therapies for T-cell Lymphomas / Francine M. Foss -- Overview of Stem Cell Transplantation for Lymphoma / Karen Ballen -- Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas / Natthapol Songdej, Eric S. Winer -- The Role of Hematopoietic Stem Cell Transplantation for HIV-Associated Lymphomas / Pascual Balsalobre, David Serrano, Jorge Gayoso, Juan Berenguer, José L. Díez-Martín -- The Role of Hematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphomas / Jenna D. Goldberg, Carla Casulo, Steven M. Horwitz.
  • 2015 Springer
    Andrew M. Evens, Kristie A. Blum, editors.
    This book provides clinical practitioners and the research community with detailed information on the diagnosis, prognosis, and treatment of non-Hodgkin lymphoma, taking into account the significant growth in knowledge including multiple therapeutic advances that have been achieved over the past 5-10 years. The work is subdivided into epidemiology, pathogenesis, pathology, imaging, and therapy of the non-Hodgkin lymphomas. The full range of therapeutic options are examined according to the major subtypes of non-Hodgkin lymphoma and the most up-to-date information is provided on current standard treatment options, including stem cell transplantation as well as new cutting-edge therapeutics.
    Also available: Print – 2015
  • 2013 Future Med
    editors, Antonino Carbone, Anas Younes.
    Non-Hodgkin lymphomas : advanced diagnostics and personalized therapies / Antonino Carbone & Anas Younes -- Lymphoma classification : past, present and future / Stefano A. Pileri, Claudio Agostinelli, Elena Sabattini, Francesco Bacci, Carlo Sagramoso, Alessandro Pileri Jr., Brunangelo Falini & Pier Paolo Piccaluga -- Immunophenotyping of non-Hodgkin lymphomas / Annunziata Gloghini & Laurence de Leval -- Pathologic diagnosis : molecular genetics / Francesco Bertoni -- Flow cytometry immunophenotyping: minimal residual disease / Pietro Bulian & Cristina Feruglio -- PET imaging / Nicolas Mounier & Nihal Martis -- Staging and prognosis / Matthew Lunning & James O. Armitage -- Which therapies for which patients / Meghan Karuturi & Anas Younes -- Chemotherapy modalities and algorithms / Chaitra Ujjani & Bruce D. Cheson -- Radiation therapy / Mauro G. Trovò & Carlo Furlan -- Cancer vaccines and active immunotherapy / Roberta Zappasodi, Paola Filipazzi, Licia Rivoltini & Massimo Di Nicola -- Stem cell transplantation in non-Hodgkin lymphomas / Jonathan Friedberg & Shahrukh Hashmi -- B-cell chronic lymphocytic leukemia/lymphoma / Piers E.M. Patten, Charles C. Chu & Nicholas Chiorazzi -- Follicular lymphoma / Stefano Luminari, Alessandra Dondi, Irene Biasoli & Massimo Federico -- Mantle cell lymphoma / Kathrin Aprile von Hohenstaufen, Alden Moccia & Emanuele Zucca -- MALT lymphoma : extranodal marginal zone B-cell lymphoma of MALT / Anastasios Stathis, Francesco Bertoni, Emanuele Zucca & Franco Cavalli -- Mycosis fungoides and other cutaneous T-cell lymphomas / Dario Tomasini, Marco Lucioni, Marco Paulli & Emilio Berti -- Peripheral T-cell lymphoma / David Sibon & Christian Gisselbrecht -- Management of elderly patients with diffuse large B-cell lymphomas / Michele Spina, Rosanna Ciancia & Umberto Tirelli -- Virus-associated non-Hodgkin lymphomas / Paolo De Paoli & Antonino Carbone -- Intrafollicular neoplasia/in situ lymphoma / Antonino Carbone & Annunziata Gloghini -- Index.
  • 2015 Springer
    Faruque Riffat, Carsten E. Palme, Michael Veness, editors.
    Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.
  • 2010 Springer
    Gregor B.E. Jemec, Lajos Kemény, Donald Miech (eds).
  • 2002 Karger
    volume editors, Wolfgang Dörr, Rita Engenhart-Cabillic, Jörg S. Zimmermann.
    Also available: Print – 2002
  • 2012 Springer
    edited by Jörg Reichrath, Sandra Reichrath.
    The Molecular Basis of Notch Signaling: A Brief Overview / Sang-Mo Kwon, Cantas Alev, Sang-Hun Lee and Takayuki Asahara -- The Role of Adams in Notch Signaling / Arjan J. Groot and Marc A. Vooijs -- Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch / Tomoko Yamakawa, Tomonori Ayukawa and Kenji Matsuno -- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages / Gerald Udolph -- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex / Tetsuichiro Saito -- Notch Signaling and Development of the Hematopoietic System / Ashley R. Sandy, Morgan Jones and Ivan Maillard -- Notch Signaling in Lung Development and Disease / Keli Xu, Nadeem Moghal and Sean E. Egan -- The Role of Notch Signaling in Kidney Development and Disease / Hila Barak, Kameswaran Surendran and Scott C. Boyle -- Notch Signaling and the Developing Skeleton / Timothy J. Mead and Katherine E. Yutzey -- Notch Signaling and the Developing Skin Epidermis / Daniela Massi and John Panelos -- Notch Signaling and the Developing Hair Follicle / Geneviève Aubin-Houzelstein -- Notch Signaling and the Developing Inner Ear / Junko Murata, Katsuhisa Ikeda and Hideyuki Okano -- Notch Signaling in Cancer Stem Cells / Jialiang Wang, Bruce A. Sullenger and Jeremy N. Rich -- Notch Signaling Pathway and Cancer Metastasis / Yi-Yang Hu, Min-hua Zheng, Rui Zhang, Ying-Min Liang and Hua Han -- Notch, Apoptosis and Cancer / Thao P. Dang -- Ligand-Dependent Notch Signaling in Vascular Formation / Tsutomu Kume -- Notch and the p53 Clan of Transcription Factors / Klaus Roemer -- Notch Signaling and Breast Cancer / Michael Reedijk -- Notch Signaling and Malignant Melanoma / Cornelia S. L. Müller -- Notch-Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited / Jörg Reichrath and Sandra Reichrath -- Notch Signaling and Intestinal Cancer / Sandra Guilmeau -- Notch Signaling and Brain Tumors / Marie-Thérése Stockhausen, Karina Kristoffersen and Hans Skovgaard Poulsen -- Notch Inhibition as a Promising New Approach to Cancer Therapy / Benjamin Purow.
    Also available: Print – 2012
  • 2012 Springer
    George G. Chen, Paul B.S. Lai, editors.
    Apoptosis Inducer from Streblus asper Extracts for Cancer Chemoprevention / Azman Seeni, Nur Ayunie Zulkepli and Ridhwan Abdul Wahab -- Apoptosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Signaling Networks / Nagini Siddavaram and Vidya Priyadarsini Ramamurthi -- Heterocyclics as Inducers of Apoptosis / Ahmed Kamal, Adla Mallareddy and Paidakula Suresh -- Anthocyanins as Apoptotic Regulators / Jairam Vanamala, Sridhar Radhakrishnan, Lavanya Reddivari and Aaron Massey -- Apoptosis as a Mechanism Involved in the Anticancer Effect of Dietary n-3 Polyunsaturated Fatty Acids / Simona Serini, Elena Fasano, Elisabetta Piccioni, Achille Renato Maria Cittadini and Gabriella Calviello -- Apoptotic Pathways upon Arsenite Treatment / Dongyun Zhang and Chuanshu Huang -- Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges / Danielle D. Jandial, Anne R. Simoneau and Xiaolin Zi -- Progesterone Receptor Modulators Induce Apoptosis in Mammary Tumors and Uterine Leiomyomas / Konstantin Christov and Ronald D. Wiehle -- Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma / Subhadeep Das and Malay Chatterjee -- Curcumin Analogs as Inhibitors of the Jak-STAT Signal Transduction Pathway / Jennifer Yang and Gregory B. Lesinski -- Targeting Cancer by Betulin and Betulinic Acid / René Csuk.
  • 2016 Springer
    edited by Vered Stearns.
    1 Genomic Biomarkers for Cancer Risk -- 2 Epigenetic Biomarkers of Breast Cancer Risk: Across the Breast Cancer Prevention Continuum -- 3 Incorporating Biomarkers in Studies of Chemoprevention -- 4 Breast Molecular Profiling and Radiotherapy Considerations -- 5 Prognostic and Predictive Biomarkers of Endocrine Responsiveness For Estrogen Receptor Positive Breast Cancer -- 6 Biomarkers for predicting response to Anti-HER2 Agents -- 7 Intratumor Heterogeneity in Breast Cancer -- 8 Intratumor Heterogeneity in Breast Cancer -- 9 Pharmacogenetic Predictors of Response -- 10 Metabolomics in Breast Cancer: Current Status and Perspectives -- 11 Circulating Tumor Cells -- 12 Circulating Plasma Tumor DNA.
    Also available: Print – 2016
  • 2012 Springer
    Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors.
    Part 1. Basic Science and Experimental Studies on Stem Cell Mobilization -- Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells -- Molecular Pharmacology of CXCR4 Inhibition -- Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors -- Should We Stay or Should We Go Now? -- Cell Adhesion and Mobilization Pathways of Hematopoietic Cells -- Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking -- Part 2. Clinical Studies on Stem Cell Mobilization -- Front matter -- Early Studies of AMD3100/Plerixafor in Healthy Volunteers -- The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation -- Experience with Apheresis Procedures After Plerixafor Mobilisation -- Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation -- Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and Non-Hodgkin's Lymphoma -- Plerixafor: Data from the Compassionate Use Program -- Stem Cell Mobilization with Chemomobilization Plus Plerixafor in Hard-to-Mobilize Patients: The Experience at Kuopio University Hospital, Finland -- Blood Stem Cell Mobilization in Solid Tumors: Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization -- Mobilization with Chemotherapy + G-CSF + Plerixafor in Europe: The Italian Experience -- Experience with Plerixafor in Poor Mobilizers -- CXCR4 Antagonists -- Part 3. CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors -- Front matter -- Application of CXCR4 Inhibitors in Leukemia -- CXCR4 Antagonists for the Treatment of CML -- Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience -- CXCR4-Blockade for Treatment of Breast Cancer -- Molecular Imaging of CXCR4 Receptor Expression in Tumors -- Part 4. Novel applications -- Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells -- Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation -- Mobilization for Gene Therapy.
  • 2005 Springer
    Zofia Zukowska, Giora Z. Feuerstein, editors.
    Also available: Print – 2005
  • 2013 Springer
    H. William Strauss, Giuliano Mariani, Duccio Volterrani, Steven M. Larson, editors.
    Nuclear Oncology: Pathophysiology and Clinical Applications is a comprehensive textbook covering the increasing role of radionuclide-based technologies in the management of oncologic patients, with disease-oriented chapters giving a detailed overview of current indications and developments. Topics covered include instrumentation, physics, radiobiology, radioguided surgery, and radionuclide therapy, which is discussed with useful separate topics describing the importance of organ function assessment after cancer therapies in the heart, lung, kidney and the gastro-intestinal tract. Additionally, significant aspects of cancer biology and molecular imaging are discussed, as well as appropriate tracers for both single- and positron-emitting radionuclides. Individual chapters in the book focus on the most common cancers occurring in adults and children, detailing radionuclide procedures within an integrated framework identifying the information required for effective treatment of specific tumors. These clinical chapters provide a description of the epidemiology, etiology, histologic and pathophysiologic classification, prognosis, treatment, and most common outcome for each type of cancer. With contributions from a group of internationally-distinguished practitioners, Nuclear Oncology: Pathophysiology and Clinical Applications serves as a valuable compendium of knowledge for nuclear medicine physicians and radiologists and other clinicians involved in the care and management of cancer patients.
  • 2012 Springer
    Fazlul H. Sarkar, editor.
    This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
  • 2006 CRCnetBASE
    edited by Sang-Woon Choi, Simonetta Friso.
  • 2006 CRCnetBASE
    edited by Atif B. Awad, Peter G. Bradford.
  • 2005 Karger
    5th International Conference on Nutrition and Fitness, Athens, June 9-12, 2004 ; volume editor, Artemis P. Simopoulos.
    Criteria and classification of obesity in Japan and Asia-Oceania / M. Kanazaw ... [et al.] - Exercise and obesity in China / C. Chang -- Obesity in childhood: the Greek experience / A. Kafatos, C.A. Codrington, M. Linardakis -- Epidemiology of physical activity from adolescence to young adulthood / D.J. Aaron, Y.S. Jekal, R.E. Laporte -- Adolescent obesity and physical activity / N. Hwalla, A.M. Sibai, N. Adra -- Nutrition and physical activity of the population in Serbia / M. Pavlovic, V. Grujic, A. Oshaug -- Physical activity and body composition / D. Andreoli, A. De Lorenzo -- Syndrome X: clinical aspects / D. Labadarios -- Metabolic syndrome: is there a pathophysiological common denominator?: lessons learned from the Pima Indians / P.A. Tataranni -- Lifestyle-gene-drug interactions in relation to the Metabolic syndrome / L. Storlien ... [et al.] -- Coronary heart disease, genetics, nutrition and physical activity / M.B. Donati, I. Iacoviello -- Role of nutrients and physical activity in gene expression / R. De Caterina, R. Madonna -- Physical activity and hypertension: an overview / G.P. Rontoyannis -- Omega-3 fatty acids and ventricular arrhythmias / A. Leaf, J.X. Kang, Y.-F. Xiao -- A method for the direct evaluation of the fatty acid status in a drop of blood from a fingertip in humans: application to population studies and correlations with biological parameters / F. Marangoni, C. Colombo, C. Galli -- Measurement error in the assessment of interaction between dietary and genetic factors in cohort studies of cancer / S.A. Bingham -- Cancer frequency in poor rural communities consuming a very limited diet / M. Muñoz Rivera ... [et al.] -- Omega-6/omega-3 polyunsaturated fatty acids ratio and breast cancer / P. Bougnoux, V. Maillard, V. Chajés -- Fish, [omega]-3 polyunsaturated fat intake and cancer at selected sites / A. Tavani ... [et al.] -- Cancer risk reduction by physical exercise / A. Willer.
  • 2012 Springer
    Sharmila Shankar, Rakesh K. Srivastava, editors.
    Aberrant Signaling Pathways in Cancer: Modulation by the Dietary Flavonoid, Quercetin / Ramamurthi Vidya Priyadarsini and Siddavaram Nagini -- Micronutrients and Cancer: Add Spice to Your Life / Sahdeo Prasad, Subash C. Gupta and Bharat B. Aggarwal -- Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics / Laura M. Beaver, David E. Williams, Roderick H. Dashwood and Emily Ho -- Molecular Insight and Preclinical Perspective of Thymoquinone as Chemopreventive Agent and Therapeutic Adjunct in Cancer / Sanjeev Banerjee, Mansi Parasramka, Fazlul H. Sarkar and Ramzi M. Mohammad -- Dietary Biofactors in the Management of Cancer: Myth or Reality? / Vidushi S. Neergheen-Bhujun, K. S. Kang, O. I. Aruoma and T. Bahorun -- Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition / Kristin Landis-Piwowar, Elizabeth Smerczak, Jian Zuo and Q. Ping Dou -- STAT Signaling in Cancer Prevention / Su-Ni Tang, Sharmila Shankar and Rakesh K. Srivastava -- [gamma][delta] T Cells, Tea and Cancer / Jingwei Lu, Vincent J. Pompili and Hiranmoy Das -- Phytochemical Intakes with a Mediterranean Diet: Levels Achievable with an Exchange List Diet and Potential Biomarkers in Blood / Zora Djuric -- Plant Polyphenols and Their Role in Cancer Prevention and Chemotherapy / Sharmila Shankar, Brahma N. Singh and Rakesh K. Srivastava -- Role of Food Micro-molecules in the Prevention of Cancer / Latha Sabikhi, Alok Jha, Sudhir Kumar Tomer and Ashish Kumar Singh. The Protective Role of Zinc in Cancer: A Potential Chemopreventive Agent / Bin Bao, Amir Ahmad, Azfar S Azmi, Zhiwei Wang and Sanjeev Banerjee, et al. -- Diet-Induced Epigenetic Changes and Cancer Prevention: A Mantra for Healthy Living / Ajay Goel and Gaurav Chaturvedi -- Western Diet-Induced Pancreatic Cancer / M. Mura Assifi and Guido Eibl -- Intracellular Signaling Network as a Prime Chemotherapy Target of Green Tea Catechin, (-)-Epigallocatechin-3-gallate / Brahma N. Singh, Sharmila Shankar and Rakesh K. Srivastava -- Role of Dietary Antioxidants in Cancer / C. M. Ajila and S. K. Brar -- Curcumin: Structure, Biology and Clinical Applications / Sharmila Shankar and Rakesh K. Srivastava -- Obesity, Cancer and Psychopathology: Can Vegetarian Diet Be of Help? / Vikas Kumar, Ajit Kumar Thakur and Shyam Sunder Chatterjee -- Dietary Phytochemicals as Epigenetic Modulators in Cancer / Vijay S. Thakur and Sanjay Gupta -- Modulation of the Nrf2 Signaling Pathway by Chemopreventive Dietary Phytoconstituents / Altaf S. Darvesh and Anupam Bishayee -- Role of Fish Oil from Gene Expression to Pharmacological Effect in Cancer Prevention / Malay Chatterjee, Subhadeep Das, Mary Chatterjee and Kaushik Roy -- Antioxidant Supplements: An Evidence-Based Approach to Health Benefits and Risks / Goran Bjelakovic, Dimitrinka Nikolova and Christian Gluud -- Natural Antioxidants and Their Role in Cancer Prevention / Akanksha Singh, Akansha Jain, Birinchi Kumar Sarma, Alok Jha and H. B. Singh -- Dietary and Non-dietary Phytochemicals in Cancer Control / Dhanir Tailor and Rana P. Singh.
  • 2012 Springer
    Alvaro Luis Ronco, Eduardo De Stéfani [editors].
  • 2012 Springer
    Nagi B. Kumar.
    Assessment of Malnutrition and Nutritional Therapy Approaches in Cancer Patients -- Cancer Anorexia (CA) -- Cancer Cachexia (CC) -- Oral Mucositis -- Nausea and Vomiting in Cancer -- Cancer-Related Fatigue (CRF) -- Treatment-Induced Enteritis (Radiation- or Combination Therapy-Induced Enteropathies) -- Neurocognitive Impairment (NI) -- Dysfunction of the Bowel/Constipation -- Dysphagia.
  • 2006 ScienceDirect
    editor-in-chief, David Heber.
    Also available: Print – 2006
  • 2014 Springer
    Kristy A. Brown, Evan R. Simpson.
    Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.This SpringerBrief will explore all of these issues in depth and the authorsare in a unique position to write about this topic,havingextensive experience in the field of aromatase research.
  • 2013 Springer
    Andrew J. Dannenberg, Nathan A. Berger, editors.
    In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.
  • 2014 Springer
    Sisko L. Anttila, Paolo Boffetta, editors.
    This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed to carcinogens, and strategies for prevention of occupational cancer are also discussed. Occupational Cancers is aimed at oncologists, pathologists, residents in training, clinical researchers, clinicians in occupational health, epidemiologists, pulmonologists, lawyers and public health officials.
  • 2014 Springer
    Arun D. Singh, editor.
    This book a conjoint effort of ocular oncologists, general oncologists, and pathologists is a comprehensive source of authoritative information on the subject of ocular and adnexal lymphoma. It covers all aspects, including clinical features, classification, epidemiology, diagnostic evaluation, biopsy techniques, histology and molecular pathology, staging procedures, and treatment methods. Detailed information is provided on primary vitreoretinal and adnexal lymphomas and chapters are also included on rare variants such as T cell lymphoma and reactive lymphoid hyperplasia of the ocular adnexa. The emphasis throughout is on easy readability, and the layout ensures rapid retrieval of information. In order to convey fundamental concepts, numerous tables, clinical photographs, histopathologic microphotographs, and imaging studies (fluorescein and indocyanine angiograms, ultrasonograms, CT scans, and MR images) are included.
  • 2014 Future Med
    editors, Timothy G. Murray, H. Culver Boldt.
    Ocular melanoma: advances in diagnostic and therapeutic strategies / Timothy G. Murray & H. Culver Boldt -- Laboratory discoveries in uveal melanoma / Aart G. Jochemsen & Martine J. Jager --Incidence, prevalence and epidemiology of ocular melanoma / Tero Kivelä -- Clinical features and diagnosis / Katrina Mears & H. Culver Boldt -- Diagnostic imaging in ocular melanoma / Timothy G. Murray, Fiona J. Ehlies, Andrea Wildner & Aaron S. Gold -- Genetics of ocular melanoma and implications for patient risk / Bertil Damato & Sarah E. Coupland -- Biopsy approaches and testing strategies for genomic prognostication / Carlos A. Medina & Arun D. Singh -- Preoperative clinical evaluation and imaging for uveal melanoma / Sohpie Piperno-Neumann, Vincent Servois, Pascale Mariani & Laurence Desjardins -- Regional anesthesia for surgical management of ocular melanoma / Jacqueline Tutiven & Michael Vigoda -- Enucleation surgery in advanced ocular disease / Daniel Gologorsky & Timothy G. Murray -- Brachytherapy for uveal melanoma / Samuel K. Houston 3rd, H. Culver Boldt & Timothy G. Murray -- Charged particle radiotherapy for ocular melanoma / Ivana K. Kim, Anne Marie Lane, Helen A. Shih & Evangelos S. Gragoudas -- Adjunctive treatment strategies for high-risk ocular melanoma / Sapna P. Patel & Dan S. Gombos -- Treatment strategies for clinically detectable metastatic uveal melanoma / Aakanksha Prasad Asija, Makoto Yoshida & Takami Sato -- Surveillance for early detection of metastatic ocular melanoma following definitive local therapy / Jasmine H. Francis, Tero Kivelä & Richard D. Carvajal -- Ophthalmic screening for postradiotherapy complications: implications for treatment and visual outcomes / Samuel K. Houston 3rd, Nisha Shah & Timothy G. Murray -- Collaborative Ocular Melanoma Study: overview of outcomes / Barbara S. Hawkins -- Surgical management of radiation-related complications / Samuel K. Houstin 3rd & Timothy G. Murray -- Visual rehabilitation for ocular melanoma / Aaron S. Gold, Azeema Latiff & Timothy G. Murray -- Index.
  • 2014 Springer
    Debmalya Barh, editor.
    Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis, and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine, and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology, and pharmacy.
  • 2010 Springer
    William C.S. Cho, editor.
  • 2014 Springer
    Teresa K. Woodruff, Marla L. Clayman, Kate E. Waimey, editors.
    Oncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information. As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably. Oncofertility Communication describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field.
  • 2010 Springer
    Teresa K. Woodruff, Laurie Zoloth, Lisa Campo-Engelstein, Sarah Rodriguez, editors.
    Part I. The Science and Technology of Oncofertility -- Reproductive health after cancer -- Designing follicle-environment interactions with biomaterials -- Gamete preservation -- To transplant or not to transplant: that is the question -- Clinical cases in oncofertility -- Cancer genetics: risks and mechanisms of cancer in women with inherited susceptibility to epithelial ovarian cancer -- Protecting and extending fertility for females of wild and endangered mammals -- -- Part II. Historical and Legal Perspectives -- Placing the history of oncofertility -- Medical hope, legal pitfalls: potential legal issues in the emerging field of oncofertility -- Domestic and international surrogacy laws: implications for cancer survivors -- -- Part III. Clinical and Theoretical Ethics -- Adoption after cancer: adoption agency attitudes and perspectives on the potential to parent post-cancer -- Ovarian tissue cryopreservation and bioethical discourse -- Lessons of oncofertility for assisted reproduction -- Morally justifying oncofertility research -- Ethical dilemmas in oncofertility: an exploration of three clinical scenarios -- Participation in investigational fertility preservation research: a feminist research ethics approach -- Reproductive "choice" and egg freezing -- Impact of infertility: why ART should be a higher priority for women in the global south -- Oncofertility and informed consent: addressing beliefs, values, and future decision making -- -- Part IV. Religious Perspectives -- Bioethics and oncofertility: arguments and insights from religious traditions -- Sacred bodies: considering resistance to oncofertility in Muslim communities -- Unlikely motherhood in the Qur'an: oncofertility as devotion -- Technology and wholeness: oncofertility and Catholic tradition -- Jewish perspectives on oncofertility: the complexities of tradition -- -- Part V. Ramifications for Education and Economics -- Oncofertility Saturday academy: a paradigm to expand the educational opportunities and ambitions of high school girls -- Myoncofertility.org: a web-based patient education resource supporting decision making under severe emotional and cognitive overload -- Anticipating ovarian tissue cryopreservation in the health-care marketplace: a willingness to pay assessment -- Perspectives on oncofertility from demography and economics -- For the sake of consistency and fairness: why insurance companies should cover fertility preservation treatment for iatrogenic infertility -- -- Part VI. Repercussions of Oncofertility for Patients and Their Families -- Health provider perspectives on fertility preservation for cancer patients -- Counseling and consenting women with cancer on their oncofertility options: a clinical perspective -- Fertility-related treatment choices of cancer patients: cancer-related infertility and family dynamics -- Whose future is it?: ethical family decision making about daughters' treatment in the oncofertility context -- -- Part VII. Healthcare Provider Stories and Final Thoughts -- Choosing life when facing death: understanding fertility preservation decision-making for cancer patients -- Discussing fertility preservation with breast cancer patients -- Warning: Google can be hazardous to your health: fertility preservation is an important part of cancer care -- Role of a patient navigator in fertility preservation -- Judaism and reproductive technology -- Reading between the lines of cancer and fertility: a provider's story -- Rewarding experience for a pediatric urologist -- Final thoughts.
    Also available: Print – 2010
  • 2007 Springer
    edited by Teresa K. Woodruff, Karrie Ann Snyder.
    Part I. Introduction -- The emergence of a new discipline: oncofertility / Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Fertility management for women with cancer / Sanjay K. Agarwal and R. Jeffrey Chang -- Fertility preservation in adult male cancer patients / Robert E. Brannigan -- Managing fertility in childhood cancer patients / Kimberley J. Dilley -- Fertility risk in pediatric and adolescent cancers / Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Bioengieneering and the ovarian follicle / Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- The science of cryobiology / Steven F. Muller and John K. Critser -- Ovarian tissue cryopreservation and transplantation: banking reproductive potential for the future / David Lee -- Progress, history and promise of ovarian cryopreservation and transplantation for pediatric cancer patients / Yasmin Gosiengfiao -- Part IV. Health care decision-making -- Oncofertility and the social sciences / Karrie Ann Snyder -- Shared decision making: fertility and pediatric cancers / Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston -- Part V. Ethical and psychosocial impact of cancer-related infertility -- Today's research, tomorrows cures: the ethical implications of oncofertility / Leilah E. Backhus and Laurie Zoloth -- The psychosocial context of cancer-related infertility / Matthew J. Loscalzo and Karen L. Clark -- Childhood cancer: fertility and psychosocial implications / Karen E. Kinahan, Aarati Didwania, and Carrie L. Nieman -- Fertility preservation and adolescent cancer patients: lessons from adult survivors of childhood cancer and their parents / Carrie L. Nieman ... [et al.] -- Part VI. Training in a new medical discipline and medical guidelines -- Oncofertility: a new medical discipline and the emerging scholar / Laxmi A. Kondapalli -- Oncofertility Consortium consensus statement: guidelines for ovarian tissue cryopreservation / Leilah E. Backhus ... [et al.] -- Part VII. Patient stories and oncofertility -- Personal accounts of cancer and infertility / provided by Fertile Hope.
    Also available: Print – 2007
  • 2008 Springer
    volume editor, Guido Kroemer ... [et al.].
  • 2005 Springer
    edited by William J. LaRochelle, Richard A. Shimkets.
    Also available: Print – 2005
  • 2008 Springer
    Wolfgang Mohnike, Gustav Hör, Heinrich R. Schelbert (eds.) ; with contributions by Thomas Beyer, Konrad Mohnike, Stefan Käpplinger.
  • 2014 Springer
    Carlo Mariotti, editor ; forewords by Giorgio De Toma, Umberto Veronesi.
    This book presents the most recent developments in oncologic breast surgery and takes full account of diagnostic, pathologic, and radiologic inputs. It is divided into three parts, the first of which discusses the premises underlying the modern surgical approach to breast cancer. The second part is devoted to what might be termed the conservative program, i.e., breast conservation and oncoplastic surgery, conservative mastectomy, and sentinel node biopsy and axillary dissection. The final part of the book covers different forms of surgery and other treatments in particular settings. Topics include plastic and reconstructive surgery, DCIS surgery, radio-guided surgery, adjuvant systemic therapy, intraoperative radiotherapy, and the role of surgery in locally advanced and metastatic disease. The detailed descriptions of techniques are accompanied by numerous high-quality illustrations. This book will be of value to both experienced practitioners and surgical trainees. .
  • 2016 Springer
    Ellen F. Manzullo, Carmen Esther Gonzalez, Carmen P. Escalante, Sai-Ching J. Yeung, editors.
    Neurologic Emergencies -- Metabolic and Endocrine Oncologic Emergencies -- Cardiac Emergencies in Cancer Patients -- Pulmonary and Airway Emergencies -- Gastrointestinal Emergencies in the Oncology Patient -- Nephro-urologic Emergencies in Patients with Cancer -- Rheumatologic/Orthopedic Emergencies -- Cancer Care Ethics in the Emergency Center -- Emergencies in Infectious Diseases -- Hematologic Emergencies -- Chemotherapy-Related Emergencies -- Palliative Care in the Emergency Center -- Psychiatric Emergencies -- Pediatrics -- Obstetric and Gynecologic Emergencies in Cancer Patients -- Dermatologic Emergencies -- Ophthalmologic Emergencies.
  • 2016 Springer
    Knox H. Todd, Charles R. Thomas, Jr., editors ; associate editors: Steven L. Bernstein, Tammie E. Quest. Sai-Ching Jim Yeung.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Paul M. Silverman, editor-in-chief.
    Here's the multidisciplinary guidance you need for optimal imaging of malignancies. Radiologists, surgeons, medical oncologists, and radiation oncologists offer state-of-the-art guidelines for diagnosis, staging, and surveillance, equipping all members of the cancer team to make the best possible use of today's noninvasive diagnostic tools. Consult with the best. Dr. Paul M. Silverman and more than 100 other experts from MD Anderson Cancer Center provide you with today's most dependable answers on every aspect of the diagnosis, treatment, and management of the cancer patient. Recognize the characteristic presentation of each cancer via current imaging modalities and understand the clinical implications of your findings. Effectively use traditional imaging modalities such as Multidetector CT (MDCT), PET/CT, and MR in conjunction with the latest advances in molecular oncology and targeted therapies. Find information quickly and easily thanks to a consistent, highly templated format complete with "Key Point" summaries, algorithms, drawings, and full-color staging diagrams. Make confident decisions with guidance from comprehensive algorithms for better staging and imaging evaluation. Access the fully searchable text online, along with high-quality downloadable images for use in teaching and lecturing and online-only algorithms, at expertconsult.com. .
  • 2016 Springer
    edited by Juliano Cerci, Stefano Fanti, Dominique Delbeke.
    PART I. Biopsy guided PET/CT: Principle of biopsy guided imaging -- FDG PET/CT to guide biopsy: methods -- FDG PET/CT to guide biopsy: type of acess -- PART II. FDG PET/CT in lymphoma: Need of biopsy in lymphoma -- FDG PET/CT to guide biopsy in lymphoma: results -- PART III. FDG PET/CT in pancreatic lesions:Need of biopsy in pancreatic lesions -- FDG PET/CT to guide biopsy in pancreatic lesions: results -- PART IV. FDG PEM in breast lessions: Need of biopsy in breast lesions -- FDG PEM to guide biopsy in breast lesions: results -- PART V. PET/CT and CNS malignancies: Need of biopsy in CNS malignancies -- FDG PET/CT to guide biopsy in CNS: results -- PART VI. PET/CT and prostate cancer -- Choline PET/CT to guide biopsy in prostate cancer diagnosis -- PART VII. FLT PET/CT in cancer diagnosis: FLT PET/CT in cancer diagnosis: results.
  • 2006 Springer
    edited by Alfred E. Chang ... [et al.].
    Sect. 1. Principles of oncology. Evidence-based approach to oncology -- Principles of chemotherapy -- Principles of radiation oncology -- Principles of surgical therapy in oncology -- Principles of targeted and biological therapies -- Biologic principles of hematopoietic stem cell transplantation -- Evaluation of tumor markers: an evidence-based guide for determination of clinical utility -- Design and analysis of oncology clinical trials -- Ethics of clinical oncology research -- Informatics infrastructure for evidence-based cancer medicine -- Economics of cancer care -- Principles of screening for cancer -- Patient decision making -- Establishing an interdisciplinary oncology team -- Principles of complementary and alternative medicine for cancer -- Sect. 2. Translational basic science. Fundamental aspects of the cell cycle and signal transduction -- Viral carcinogenesis -- Environmental carcinogenesis -- Cancer metastasis -- Tumor immunology and immunotherapy -- Technologies in molecular biology: diagnostic applications -- Sect. 3. Cancer prevention and control. Cancer epidemiology -- Evidence-based cancer prevention research: a multidisciplinary perspective on cancer prevention trials -- Screening -- Genetic screening and counseling for high-risk populations -- Behavior modification -- Sect. 4. Cancer imaging. Central nervous system imaging -- Breast imaging -- Imaging of throacic malignancies -- Imaging of gastrointestinal stromal tumor -- Genitourinary imaging -- Musculoskeletal imaging -- Positron emission tomography and cancer -- Sect. 5. Solid tumors. Central nervous system tumors -- Eye, orbit, and adnexal structures -- Head and neck cancer -- Lung cancer -- Therapy for malignant pleural mesothelioma -- Mediastinum -- Esophageal cancer -- Stomach -- Colon, rectal, and anal cancer management -- Adenocarcinoma and other small intestinal malignancies -- Cancer of the lung and bile ducts -- An evidence-based approach to the management of pancreatic cancer -- Renal cell cancer -- Ureter, bladder, penis, and urethra -- Prostate cancer -- Testis cancer -- Cervix, vulva, and vagina -- Gastational trophoblastic neoplasms -- Ovarian cancer -- Uterine malignancies -- Evidence-based management of breast cancer -- Thyroid and Parathyroid -- Tumors of the endocrine system -- Sarcomas of bone -- Soft tissue sarcoma -- Cutaneous melanoma -- Nonmelanoma cutaneous malignancies -- Cancer of unknown primary site -- Solid tumors of childhood -- Sect. 6. Hematologic malignancies. Acute myeloid leukemia and the myelodysplastic syndromes -- Acute lymphoblastic leukemia -- Chronic lymphocytic leukemia and related chronic leukemias -- Chronic myeloid leukemia -- An evidence-based approach to the management of Hodgkin's lymphoma -- The non-Hodgkin's lymphomas -- Multiple myeloma -- Sect. 7. Practice of oncology. Superior vena cava syndrome -- Central nervous system emergencies -- Metabolic emergencies in oncology -- Surgical emergencies -- Oral complications of cancer therapy -- Alopecia and cutaneous complications of chemotherapy -- Infectious complications of cancer therapy -- Acute toxicities of therapy: pulmonary complications -- Cardiac complications -- Neurologic complications of therapy -- Acute toxicities of therapy: urologic complications -- Issues in vascular access with special emphasis on the cancer patient -- Management of cancer pain -- Nausea and vomiting in the cancer patient -- Nutritional support for the cancer patient -- Paraneoplastic syndromes -- Malignant effusions -- Evidence-based use of hematopoietic growth factors for optimal supportive care of patients with cancer -- Management of the bone marrow transplant patient -- Management of anxiety and depression in adult cancer patients: toward an evidence-based approach -- Reproductive complications and sexual dysfunction in the cancer patient -- Metastatic cancer to the central nervous system -- Metastatic cancer in lung -- Surgical and regional therapy for liver metastases -- Metastatic cancer to bone -- Cancer in the immunosuppressed patient -- Cancer in the older population -- Chemotherapy in patients with organ dysfunction -- Management of the pregnant cancer patient -- Sect. 8. Cancer survivorship. Survivorship research: past, present, and future -- Late effects of cancer treatments -- Medical and psychosocial issues in childhood cancer survivors -- Medical and psychosocial issues in Hodgkin's disease survivors -- Medical and psychosocial issues in testicular cancer survivors -- Medical and psychosocial issues in testicular cancer survivors -- Medical and psychosocial issues in gynecologic cancer survivors -- Medical, psychosocial, and health-related quality of life issues in breast cancer survivors -- Medical and psychosocial issues in prostate cancer survivors -- Physical and psychosocial issues in lung cancer survivors -- Cancer survivorship issues in colorectal cancer -- Medical and psychosocial issues in transplant survivors -- Second malignancies after radiation treatment and chemotherapy for primary cancers -- Psychosocial rehabilitation in cancer care -- Cancer advocacy.
  • 2008 Ovid
    book editor, Timothy A. Damron.
    Section I: Evaluation and management of musculoskeletal oncology problems -- Evaluation of bone tumors / Timothy A. Damron -- Evaluation of soft tissue tumors / Carol D. Morris -- Biopsy of musculoskeletal tumors / Edward A. Athanasian -- Treatment principles -- Surgical margins / Robert Quinn -- Benign tumors of bone / Cynthia M. Kelly -- Malignant bone lesions / Francis R. Patterson, Timoth A. Damron, and Carol D. Morris -- Soft tissue tumors / John Heiner and Jeremy White -- Pathologic fractures / Timothy A. Damron -- Section II: Specific bone neoplasms and simulators -- Benign bone tumors -- Bone lesions / Felasfa M. Wodajo -- Cartilage lesions / Felasfa M. Wodajo -- Cystic lesions / Sung Wook Seo, Young Lae Moon, and Francis Young-In Lee -- Myogenic, lipogenic, and neural tumors / Sean V. McGarry and C. Parker Gibbs -- Fibrous lesions of bone / Sung Wook Seo, Young Lae Moon, and Francis Young-In Lee -- Giant cell tumor of bone / Sean V. McGarry and C. Parker Gibbs -- Vascular lesions / Sean V. McGarry and C. Parker Gibbs -- Other tumors of undefined neoplastic nature / Sean V. McGarry and C. Parker Gibbs -- Bone sarcomas -- Osteosarcoma / Francis R. Patterson -- Ewing sarcoma and primitive neuroectodermal tumor of bone / Bruce Rougraff -- Chondrosarcoma / R. Lor Randall and Kenneth J. Hunt -- Fibrous, fibrohistiocytic, and giant cell tumor malignancies / Hannah D. Morgan -- Notochordal tumors / Hannah D. Morgan -- Vascular sarcomas of bone / Hannah D. Morgan -- Myogenic, lipogenic, and epithelial bone sarcomas / Hannah D. Morgan -- Congenital and inherited bone conditions -- Familial adenomatous polyposis / Kathryn Palomino -- Beckwith-Wiedemann syndrome / Danielle A. Katz -- Skeletal dysplasias / Danielle A. Katz -- Retinoblastoma syndrome / Timothy A. Damron -- Rothmund-Thomson syndrome / Kathryn Palomino -- Werner syndrome / Kathryn Palomino -- Metastatic disease / Timothy A. Damron -- Hematologic malignancies / Valerae O. Lewis -- Metabolic bone diseases / Susan V. Bukata -- Section III: Specific soft tissue neoplasms and simulators -- Benign soft tissue tumors / Timothy A. Damron and Gustavo de la Roza -- Soft tissue sarcomas / Carol D. Morris -- Section IV: Basic science -- Cellular and molecular biology / Matthew J. Allen -- Growth and development of the musculoskeletal system / Donald E. Sweet and Thomas V. Smallman -- Genetic basis of musculoskeletal disorders / Sathappan S. Sathappan, Kirill Ilalov, and Paul E. Di Cesare -- Biomechanics / Frederick W. Werner and Joseph A. Spadaro -- Biomaterials / Joseph A. Spadaro, Michael T. Clarke, and Julie M. Hasenwinkel -- Principles of orthopaedic pharmacology / Carol D. Morris -- Bone form, function, injury, regeneration, and repair / Alexia Hernandez-Soria and Mathias Bostrom -- Articular cartilage structure, composition, and repair / Peter J. Roughley and Thomas V. Smallman -- Diarthrodial joints / Thomas V. Smallman, Kris Shekitka, and Donald Flemming -- Meniscal structure, function, repair, and replacement / Mark C. Drakos and Answorth A. Allen -- Intervertebral disk structure, composition, and mechanical function / Samuel A. Joseph, Jr., and Patrick Boland -- Tendon and ligament anatomy, biology, and biomechanics / Brian J. Harley and Joseph W. Bergman -- Peripheral nerve physiology, anatomy, and pathology / Shikha Sethi ... [et al.] -- Skeletal muscle anatomy, physiology, and mechanics / Bryan T. Kelly and William J. Robertson -- Infectious disorders of bone and joint / Thomas V. Smallman ... [et al.] -- Bacterial infection -- Granulomatous infection -- Infection associated with neuropathy -- Viral disorders -- Neoplasia / Matthew J. Allen.
  • 2015 Ovid
    Barton-Burke, Margaret; Ingwersen, Karen; Wilkes, Gail M.
    Also available: Print – 2007.
  • 2010 Springer
    Jörg-Christian Tonn, Manfred Westphal, James T. Rutka (eds).
  • 2009 ClinicalKey
    Stuart H. Orkin [and others].
    To address the growing complexities of childhood cancer, this book has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients.
  • 2012 Springer Protocols
    edited by David H. Kirn, Ta-Chiang Liu, Steve H. Thorne.
    Oncolytic herpes simplex virus engineering and preparation -- Construction of capsid-modified adenoviruses by recombination in yeast and purification by iodixanol-gradient -- Construction of targeted and armed oncolytic adenoviruses -- Syrian hamster tumor model to study oncolytic Ad5-based vectors -- Adenoviral gene expression and replication in human tumor explant models -- Imaging luciferase-expressing viruses -- In vivo positron emission tomography imaging using the sodium iodide symporter as a reporter gene -- Maintaining and loading neural stem cells for delivery of oncolytic adenovirus to brain tumors -- Targeting brain tumor stem cells with oncolytic adenoviruses -- Propagation, purification, and in vivo testing of oncolytic vesicular stomatitis virus strains -- Oncolytic measles virus retargeting by ligand display -- Exploring host factors that impact reovirus replication, dissemination, and reovirus-induced cell death in cancer versus normal cells in culture -- Analysis of three properties of Newcastle disease virus for fighting cancer: Tumor-selective replication, antitumor cytotoxicity, and immunostimulation -- Next-generation oncolytic vaccinia vectors -- Evaluation of innate immune signaling pathways in transformed cells.
  • 2015 Springer
    Kenar D. Jhaveri, Abdulla K. Salahudeen, editors.
    Introduction: Onconephrology: Caring for the cancer patient with kidney disease -- Ch. 1: Acute Kidney Injury in Cancer Patients -- Ch. 2: Chronic Kidney Disease In Cancer Patients -- Ch. 3: Glomerular Diseases seen with Solid Tumors and Hematological Malignancies -- Ch. 4: Nephrotoxicity of Chemotherapy Agents -- Ch. 5: Biological Cancer Therapies and the Kidney -- Ch. 6: Rational Dosing of Chemotherapy in Patients with Kidney Failure -- Ch. 7: Electrolyte Disorders in Cancer Patients -- Ch. 8: Tumor Lysis Syndrome -- Ch. 9: Surgical and Medical Options in the Management of Renal Cell Carcinoma -- Ch. 10: Renal Cell Carcinoma and Chronic Kidney Disease -- Ch. 11: Renal Disease Following Hematopoetic Stem Cell Transplantation -- Ch. 12: Radiation Nephropathy -- Ch. 13: Dysproteinemias and kidney disease -- Ch. 14: The Amyloidoses -- Ch. 15: Obstructive Renal disease in cancer patients -- Ch. 16: Cancer in the Kidney Transplant Recipient -- Ch. 17: Cancer, Palliative Care and Acute Kidney Injury- The Hard Decisions of Offering or Not Offering Dialysis.
  • 2009 Springer
    A. Fitoussi, M.G. Berry, B. Couturaud, R.J. Salmon.
  • 2015 Springer
    Florian Fitzal, Peter Schrenk, editors.
  • 2010 Springer
    Florian Fitzal, Peter Schrenk (eds.).
    1. General Surgery -- Surgical Anatomy / Elisabeth Würinger -- Breast Cancer Surgery: Standard Principles / Florian Fitzal -- Oncoplastic Breast Surgery / Peter Schrenk -- 2. Oncoplastic Surgery (OPS) -- OPS and Breast Conserving Surgery (BSC) / Peter Schrenk, Elizabeth J. Hall-Findlay, Florian Fitzal, Andrea Grisotti and Donato Casella, et al. -- OPS and Mastectomy / Grant W. Carlson, Francesca De Lorenzi, Mario Rietjens, Andrea Manconi and Daniela Hoch, et al. -- Special Considerations / Florian Fitzal, Rupert Koller, Stefan Gärner, Elisabeth Grafinger-Witt and Mario Rietjens, et al.
  • 2009 ClinicalKey
    [edited by] Maurice Y. Nahabedian.
    Well-recognized, international authorities in breast and plastic surgery contribute their expert advice and guidance on aesthetic closure of the breast. They discuss all key areas from indication and selection of patients, to the techniques and allied issues related to breast tumor surgery, including oncoplastic reduction, mammaplasty, mastectomy with nipple areolar preservation, perfator flaps, effects of radiation therapy, as well as complications and controversies. The DVD of narrated video clips of techniques visually demonstrates procedures described within the book.
  • 2011 Springer
    Andras Szasz, Nora Szasz, Oliver Szasz.
  • 2015 Ovid
    Michael S. Sabel, MD, editor ; Michael W. Mulholland, MD, PhD, editor-in-chief, illustrations by BodyScientific International, LLC.
    Also available: Print – 2015
  • 2009 Springer
    Eben Rosenthal, Kurt R. Zinn, editors.
  • 2015 Springer
    Tadaaki Kirita, Ken Omura, editors.
    Oral cancer is frequently diagnosed late, when the disease has advanced with lesions that are large and deeply invasive and with metastasis to regional lymph nodes, leading to increased mortality. Moreover, late diagnosis and treatment often result in considerable morbidity of oral and maxillofacial structures and poor appearance and function following therapy. This book provides head and neck oncologists, oral oncologists, oral and maxillofacial surgeons, medical oncologists, dentists and other members of dental teams furnishing supportive care with a systematic review of recent diagnostic and therapeutic advances in oral cancer. The various authoritative chapters are prepared by specialists who are active leaders in each basic and clinical field. All chapters address individual and collective issues that arise in managing oral cancer patients with difficult treatment problems and provide insight into the multiple valid management approaches available. The authors offer an extensive source of information about oral cancers and encourage the clinician to be flexible and innovative, giving physicians and medical personnel the background information to make the best, educated, responsible decisions for individual patients.
  • 2010 Springer
    Jeffrey Myers, editor.
  • 2012 Springer
    Stephen T Sonis.
    Treatment tolerance is a challenge for most cancer patients, and it is therefore essential that healthcare professionals (HCP) are quick to recognize adverse events and implement management strategies to address them. This pocket book provides an in-depth guide to the epidemiology, diagnosis and management of oral mucositis, a common adverse event of chemotherapy.
  • 2015 Springer
    Zeynel A. Karcioglu.
    Orbital Tumors, 2nd edition discusses advances in orbital disease and their treatment, offering readers an up-to-date, single volume reference for orbital tumors. Divided into two parts, this book covers everything from advances in oncogenesis and its relationship to orbital tumors, to medical genetics and the role of imaging in diagnosis of orbital tumors. Additionally, new information on incidence and behavior of tumors resulting from environmental and social trends is included. Written and edited by leaders in the fields of ophthalmology and oncology, Orbital Tumors, 2nd edition builds upon the first edition, proving to be a useful reference for orbital specialists and of significant interest to everyone dealing with orbital pathology from a clinical and scientific point of view.
  • 2011
    Daniel James Dickinson.
    A fundamental characteristic of metazoans is the formation of a simple, polarized epithelium. In higher animals, the structural integrity and functional polarization of simple epithelia require a cell-cell adhesion complex containing a classical cadherin, the Wnt-signaling protein [Beta]-catenin and the actin-binding protein [Alpha]-catenin. I have investigated the evolutionary origins of epithelial cell polarity and of the cadherin-catenin complex. I show that the non-metazoan Dictyostelium discoideum forms a polarized epithelium that is essential for multicellular development. Although D. discoideum lacks a cadherin homolog, I have identified and characterized an [Alpha]-catenin ortholog that binds a [Beta]-catenin-related protein. Both proteins are essential for formation of the epithelium, polarized protein secretion and proper multicellular morphogenesis. Thus the organizational principles of metazoan multicellularity may be more ancient than previously recognized, and the role of the catenins in cell polarity predates the evolution of Wnt signaling and classical cadherins.
  • 2010 Springer
    by Shi-Ming Tu.
    Also available: Print – 2010
  • 2014 Springer
    Terrance D. Peabody, Samer Attar, editors.
    Principles of Musculoskeletal Biopsy / Raffi S. Avedian -- Imaging Evaluation of Musculoskeletal Tumors / Nicholas Morley and Imran Omar -- Benign Bone Tumors / Robert Steffner -- Osteosarcoma / Drew D. Moore and Hue H. Luu -- Ewing's Sarcoma of Bone / Drew D. Moore and Rex C. Haydon -- Chondrosarcoma of Bone / Lee R. Leddy and Robert E. Holmes -- Evaluation and Treatment of Spinal Metastatic Disease / Shah-Nawaz M. Dodwad, Jason Savage, Thomas J. Scharschmidt and Alpesh Patel -- Evaluation and Treatment of Extremity Metastatic Disease / Aaron T. Creek, Drew A. Ratner and Scott E. Porter -- Clinical Evaluation and Management of Benign Soft Tissue Tumors of the Extremities / Andrew S. Erwteman and Tessa Balach -- Soft Tissue Sarcomas / Andre Spiguel.
    Also available: Print – 2014
  • 2015 Springer
    editor, Alfonso M. Pluchinotta.
    The Breast Clinic -- The Asymptomatic Woman -- Anatomy, Congenital Aberrations, and Physiological Changes -- Clinical Examination of the Breast -- Imaging in Breast Related Diseases -- Breast Tissue Diagnosis -- Breast Pain -- Inflammatory Diseases of the Breast -- Benign Lesions of the Breast -- Nipple Discharge -- Miscellaneous Minor Disorders of the Breast -- Staging and Work Up of the Non Invasive Breast Cancer -- Staging and Work Up of Invasive Breast Cancer -- Breast Cancer Special Issues -- Breast Cancer in General Population -- The Role of Surgery -- The Role of Adjuvant Radiation Therapy -- The role of Adjuvant Systemic Therapy -- Male Breast Diseases -- Loco-Regional Breast Cancer Recurrences -- Follow Up.
  • 2010 ClinicalKey
    edited by Robert E. Bristow, Deborah K. Armstrong.
    Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for ovarian cancer. Apply expert advice on the best next-step plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered.
  • 2008 Springer
    George Coukos, Andrew Berchuck, Robert Ozols, editors.
    Also available: Print – 2008
  • 2013 Springer Protocols
    edited by Anastasia Malek, Oleg Tchernitsa.
    Ovarian cancer genome / Evgeny N. Imyanitov -- Identifying associations between genomic alterations in tumors / Joshy George ... [et al.] -- Analysis of genome-wide DNA methylation profiles by BeadChip technology / Qiong Lin, Wolfgang Wagner, and Martin Zenke -- Integrative prediction of gene function and platinum-free survival from genomic and epigenetic features in ovarian cancer / Kazimierz O. Wrzeszczynski ... [et al.] -- Survival prediction based on inherited gene variation analysis / Mine S. Cicek, Matthew J. Maurer, and Ellen L. Goode -- Main principles and outcomes of DNA methylation analysis / Susan K. Murphy, Christopher F. Bassil, and Zhiqing Huang -- Methylation-specific PCR / Zhiqing Huang, Christopher F. Bassil, and Susan K. Murphy -- Bisulfite sequencing of cloned alleles / Zhiqing Huang, Christopher F. Bassil, and Susan K. Murphy -- Bisulfite pyrosequencing / Christopher F. Bassil, Zhiqing Huang, and Susan K. Murphy -- RNA networks in ovarian cancer / Anastasia Malek -- Microarray-based transcriptome profiling of ovarian cancer cells / Juan Cui, Ying Xu, and David Puett -- Deep transcriptome profiling of ovarian cancer cells using next-generation sequencing approach / Lisha Li ... [et al.] -- Assessment of mRNA splice variants by qRT-PCR / Ileabett M. Echevarria Vargas and Pablo E. Vivas-Mejía -- MicroRNA profiling in ovarian cancer / Marilena V. Iorio and Carlo M. Croce -- Detailed analysis of promoter-associated RNA / Sara Napoli -- Integrating Multiple Types of Data to Identify MicroRNA-Gene Co-modules / Shihua Zhang -- Energy metabolism and changes in cellular composition in ovarian cancer / Anastasia Malek -- Metabolomic profiling of ovarian carcinomas using mass spectrometry / Miranda Y. Fong, Jonathan McDunn, and Sham S. Kakar -- Choline metabolic profiling by magnetic resonance spectroscopy / Egidio Iorio ... [et al.] -- Proteomic Profiling of ovarian cancer models using TMT-LC- MS/MS / John Sinclair and John F. Timms -- Characterization of signalling pathways by reverse phase protein arrays / Katharina Malinowsky ... [et al.] -- N-glycosylation analysis by HPAEC-PAD and mass spectrometry / Sebastian Kandzia and Júlia Costa -- In vivo and in vitro properties of ovarian cancer cells / Anastasia Malek -- Establishment of primary cultures from ovarian tumor tissue and ascites fluid / Brigitte L. Thériault ... [et al.] -- Ovarian cancer stem cells enrichment / Lijuan Yang and Dongmei Lai -- Assessment of resistance to anoikis in ovarian cancer / Xiaoping He, Jeremy Chien, and Viji Shridhar -- Analysis of EMT by flow cytometry and immunohistochemistry / Robert Strauss, Jiri Bartek, and André Lieber -- Challenges in experimental modeling of ovarian cancerogenesis / Jim J. Petrik -- Transformation of the human ovarian surface epithelium with genetically defined elements / Weiwei Shan and Jinsong Liu -- In vitro model of spontaneous mouse OSE transformation / Paul C. Roberts and Eva M. Schmelz -- Orthotopic, syngeneic mouse model to study the effects of epithelial-stromal interaction / James B. Greenaway and Jim J. Petrik -- Immunocompetent mouse model of ovarian cancer for in vivo imaging / Selene Nunez-Cruz and Nathalie Scholler -- Drug delivery approaches for ovarian cancer therapy / Anastasia Malek -- Polymer-based delivery of RNA-based therapeutics in ovarian cancer / Ulrike Weirauch ... [et al.] -- Ligand-coupled lipoprotein for ovarian cancer-specific drug delivery / Ian R. Corbin -- Mesoporous silicon particles for sustained gene Silencing / Nafis Hasan ... [et al.] -- Exosomes as a potential tool for a specific delivery of functional molecules / Irina Nazarenko, Anne-Kathleen Rupp, and Peter Altevogt.
  • 2009 Springer
    edited by M. Sharon Stack, David A. Fishman.
    Also available: Print – 2009
  • 2010 Springer
    edited by M.A. Hayat.
  • 2014 CRCnetBASE
    edited by Patricia B. Hoyer, The University of Arizona, College of Medicine, Tucson, USA.
    "Today, we are exposed to an ever-growing number of chemicals in the environment and there is an increasing awareness of the effects of these chemicals on the ovaries. As such, the potential for xenobiotic-induced infertility needs to be better understood. Additionally, menopause-associated disorders are of growing health concern in view of the fact that by the year 2025, 19.5% of the population of the U.S. will be menopause-aged women. Exploring research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles, this book is an essential resource for researchers in academia, regulatory agencies, and industry"--Provided by publisher.
  • 2008 Springer
    John C. Stavridis.
  • 2012 Springer
    Douglas R. Spitz, Kenneth J. Dornfeld, Koyamangalath Krishnan, David Guis, editors.
    This volume details how oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications.
  • 2013 Springer
    Pierre Hainaut, Magali Olivier, Klas G. Wiman, editors.
    TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer / Pierre Hainaut -- The Inheritance of p53 / Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson and Ying Cai, et al. -- p53: Guardian of the Metabolome / Masha V. Poyurovsky and Carol Prives -- The p53 Family and Stem Cell Biology / Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola and Gerry Melino, et al. -- Mutant p53-Driven Tumorigenesis / Tamara Terzian and Guillermina Lozano -- Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences / Monica Hollstein and Yang Xu -- p53 Models for Mammary Carcinogenesis / Wolfgang Deppert and Genrich Tolstonog -- TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers / Magali Olivier -- Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer / Anita Langerød, Magali Olivier and Anne-Lise Børresen-Dale -- TP53 Germline Mutations: Genetics of Li-Fraumeni Syndrome / Doua Bakry and David Malkin -- Tp53 Gene Therapy for Cancer Treatment and Prevention / Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang and Zhaohui Peng, et al. -- Upstream Targets in the p53 Pathway / Anna R. McCarthy and Sonia Lain -- p53-Reactivating Molecules as Research Tools and Anticancer Drugs / Vera V. Grinkevich, Andreas Warnecke and Galina Selivanova -- Targeting Mutant p53 for Improved Cancer Therapy / Jinfeng Shen, Vladimir J. N. Bykov and Klas G. Wiman -- p53 Immunotherapy of Cancer / Hakim Echchannaoui and Matthias Theobald -- Designing p53 Trials: A Surgical Oncologists View / Daniela Kandioler, Sonja Kappel and Brigitte Wolf -- p53 in the Clinic: A Pathologist's View / Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet and Sylvie Lantuejoul, et al. -- Genetic Counseling for TP53 Germline Mutations / Maria Isabel Waddington Achatz and Patricia Ashton-Prolla.
  • 2013 Springer Protocols
    edited by Sumitra Deb, Swati Palit Deb.
    Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues / Marie P. Khoury ... [et al.] -- Detecting p53 isoforms at protein level / Virginie Marcel ... [et al.] -- Autophagy, senescence, and apoptosis / Rachel W. Goehe ... [et al.] -- p53 and cell cycle effects after DNA damage / Emir Senturk and James J. Manfredi -- p53 ubiquitination and proteasomal degradation / Ian M. Love, Dingding Shi, and Steven R. Grossman -- Identification of p53 in mitochondria / Angelina V. Vaseva and Ute M. Moll -- Identification of novel mutant p53 interacting proteins by proteomic analysis / Sumitra Deb and Paul R. Graves -- Identification of small molecules affecting p53-MDM2/MDMX interaction by fluorescence polarization / Qi Zhang and Hua Lu -- Determine the effect of p53 on chemosensitivity / Emir Senturk and James J. Manfredi -- Measurement of chemosensitivity and growth rate in p53 expressing cells / Mahesh Ramamoorthy ... [et al.] -- Mutant p53 in cell adhesion and motility / W. Andrew Yeudall, Katharine H. Wrighton, and Sumitra Deb -- Use of the DNA fiber spreading technique to detect the effects of mutant p53 on DNA replication / Rebecca A. Frum, Sumitra Deb, and Swati Palit Deb -- Generation of p53-deficient induced pluripotent stem cells from mouse embryo fibroblasts / Evguenia M. Alexandrova and Ute M. Moll -- p53 actions on microRNA expression and maturation pathway / Hiroshi I. Suzuki and Kohei Miyazono -- Isolation and characterization of murine multipotent lung stem cells / Venkat S. Gadepalli, Catherine Vaughan, and Raj R. Rao -- Generation of p53 knock-down cell lines / Catherine Vaughan, Swati Palit Deb, and Sumitra Deb -- ChIP for identification of p53 responsive DNA promoters / Jun-Ming Liao and Hua Lu -- ChIP-on-chip to identify mutant p53 targets / Frauke Goeman, Giulia Fontemaggi, and Giovanni Blandino -- ChIP sequencing to identify p53 targets / Catherine Vaughan, Brad Windle, and Sumitra Deb.
  • 2011
    Colleen Ann Brady.
    The p53 protein suppresses tumorigenesis by inducing cell cycle arrest, apoptosis, or cellular senescence. At the molecular level p53 plays a central role as a transcriptional activator, and p53 has two amino-terminal transactivation domains important for this role. However, the contribution of each of these domains to p53 activity has not been determined in vivo. To analyze transactivation domain requirements for p53 function, we have generated a series of p53 knock-in mouse models in which we replaced the endogenous p53 gene with transactivation mutants containing point mutations in the first (p53^25,26), second (p53^53,54), or both (p53^25,26,53,54) p53 transactivation domains. These experiments are the first to address the unique contribution of each of the p53 transactivation domains in vivo. By gene expression microarray, we determined that these mutants represent an allelic series of p53 transactivation mutants, whereby p53^53,54 retains wild-type p53 transactivation potential, p53^25,26,53,54 loses nearly all p53-dependent transactivation, and p53^25,26 exhibits a severely compromised transactivation phenotype. Experiments comparing all three transactivation domain mutants in cell culture and mouse models have unveiled important differences in the function of the two transactivation domains. Apoptosis or cell-cycle arrest downstream of acute DNA damage rely on the first transactivation domain and robust p53 transactivation, while senescence and tumor suppression in response to oncogene activation can occur without the full transactivation function of p53. These results implicate unique p53 transcriptional programs in acute DNA damage responses and tumor suppression, and mechanistically distinguish these two p53 response pathways. Further, we have uncovered striking differences in the developmental phenotypes of these different mutant mice, leading to conclusions about the activity of p53 tetramers.
  • 2005 Springer
    edited by Gerard P. Zambetti.
  • 2013 ScienceDirect
    edited by Hiroshi Maruta.
    1. Functional maturation of PAKs from unicellular to multicellular organisms / Masato Okada, Graham Cote, Ramesh K. Jha, and Hiroshi Maruta -- 2. Oncogenicity of PAKs and their substrates / Hong He and Hiroshi Maruta -- 3. Natural or synthetic therapeutics that block PAKs / Hiroshi Maruta, Shanta M. Messerli, and Ramesh K. Jha -- 4. PAK1-3 in infectious diseases / Hiroshi Maruta -- 5. PAK1 in brain diseases or disorders / Hiroshi Maruta and Shanta M. Messerli -- 6. PAK1 in Alzheimer's and Huntington's diseases / Qui-Lan Ma, Fusheng Yang, Sally A. Frautschy, and Greg M. Cole -- 7. PAK1 controls the lifespan / Sumino Yamase and Hiroshi Maruta -- 8. 3D structure and physiological regulation of PAKs / Stefan Knapp.
  • 2015 Springer
    Bernd Alt-Epping, Friedemann Nauck, editors.
    Palliative care provides comprehensive support for severely affected patients with any life-limiting or life-threatening diagnosis. To do this effectively, it requires a disease-specific approach as the patients? needs and clinical context will vary depending on the underlying diagnosis. Experts in the field of palliative care and oncology describe in detail the needs of patients with advanced cancer in comparison to those with non-cancer disease and also identify the requirements of patients with different cancer entities. Basic principles of symptom control are explained, with careful attention to therapy for pain associated with either the cancer or its treatment and to symptom-guided antineoplastic therapy. Complex therapeutic strategies for palliative cancer patients are highlighted that involve both cancer- and symptom-directed options and address a range of therapeutic aims. Issues relating to drug use in palliative cancer care are fully explored, and a separate section is devoted to care in the final phase. A range of organizational and policy issues are also discussed, and the book concludes by considering likely future developments in palliative care for cancer patients. Palliative Care in Oncology will be of particular interest to palliative care physicians who are interested in broadening the scope of their disease-specific knowledge, as well as to oncologists who wish to learn more about modern palliative care concepts relevant to their day-to-day work with cancer patients.
  • 2015 Springer
    Christophe Le Tourneau, Maud Kamal, editors.
    Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers? Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.
  • 2008 Springer
    H. Riess, A. Goerke, H. Oettle (Eds.).
    Also available: Print – 2008
  • 2010 Springer
    John P. Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus W. Büchler (eds.).
    v. 1. Chapters 1-25 -- v. 2. Chapters 26-54.
  • 2013 Springer Protocols
    edited by Gloria H. Su.
    Identification and analysis of precursors to invasive pancreatic cancer / Hanno Matthaei, Marco Dal Molin, and Anirban Maitra -- Tissue microarrays : construction and use / Helen Remotti -- Immunohistochemistry of pancreatic neoplasia / Sukhwinder Kaur ... [et al.] -- Method for conducting highly sensitive MicroRNA in situ hybridization and immunohistochemical analysis in pancreatic cancer / Lorenzo F. Sempere and Murray Korc -- Optimal molecular profiling of tissue and tissue components : defining the best processing and microdissection methods for biomedical applications / Jaime Rodriguez-Canales -- Considerations for sequencing analyses of pancreatic cancer progression and metastasis / Alvin Makohon-Moore and Christine A. Iacobuzio-Donahue -- DNA methylation analysis in human cancer / Eileen O'Sullivan and Michael Goggins -- Quantitative real-time PCR expression analysis of peripheral blood mononuclear cells in pancreatic cancer patients / Michael J. Baine, Kavita Mallya, and Surinder K. Batra -- Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine / Dan Laheru, Barbara Biedrzycki, and Elizabeth M. Jaffee -- Prevention and genetics of pancreatic cancer : a programmatic approach / Aimee L. Lucas ... [et al.] -- Development of orthotopic pancreatic tumor mouse models / Wanglong Qiu and Gloria H. Su -- Evaluating Dietary Compounds in Pancreatic Cancer Modeling Systems / Emman Mascarinas, Guido Eibl, and Paul J. Grippo -- Quantification of murine pancreatic tumors by high-resolution ultrasound / Stephen A. Sastra and Kenneth P. Olive -- Microdissection and culture of murine pancreatic ductal epithelial cells / Yuliya Pylayeva-Gupta, Kyoung Eun Lee, and Dafna Bar-Sagi -- Sphere-forming assays for assessment of benign and malignant pancreatic stem cells / Yue J. Wang ... [et al.] -- Analysis of transplanted bone marrow-derived cells in chronic pancreatitis / Christoph B. Westphalen, Frederic Marrache, and Timothy C. Wang -- Analysis of the potential for pancreatic cancer metastasis in vitro and in vivo / Chen Huang and Keping Xie -- Use of fluorescent probes in the study of reactive oxygen species in pancreatic cancer cells / Richard D. Dinnen, Yuehua Mao, and Robert L. Fine -- Analysis of tumor-associated mucin glycotopes by western transfer methods / Vinayaga S. Gnanapragassam, Maneesh Jain, and Surinder K. Batra -- Evaluating tumor angiogenesis / Minji K. Uh, Jessica Kandel, and Jan Kitajewski -- Pooled shRNA screenings : experimental approach / Ruth Rodriguez-Barrueco, Netonia Marshall, and Jose M. Silva -- Pooled ShRNA screenings : computational analysis / Jiyang Yu ... [et al.].
  • 2015 Springer
    George H. Sakorafas, Vassileios Smyrniotis, Michael G. Sarr, editors.
    This book provides a thorough overview of the detection of PCNs using modern imaging techniques and a clear guide to the recognition of the different subtypes of PCN based on their radiologic and histopathologic features. This volume will serve as an excellent aid to the selection of optimal therapeutic strategies based on preoperative diagnosis. A further important feature is the emphasis placed on radiologic, clinical, and surgical correlations. Pancreatic cystic neoplasms (PCNs) have been increasingly recognized during the past decade, mainly because of the widespread use of modern imaging modalities for the investigation of often unrelated abdominal symptoms. The three most common subtypes of PCN are serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. These subtypes have distinct radiologic and histopathological features, and their biological behavior differs greatly. Accurate preoperative diagnosis is of prime importance in selecting the optimal therapeutic strategy: while serous cystic neoplasms are almost always benign, and may be treated conservatively, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms have malignant potential, warranting an aggressive surgical approach, i.e., pancreatectomy. Pancreatic Cystic Neoplasms will be of great interest to surgeons, gastroenterologists, radiologists, oncologists, and pathologists, and also to internists and residents in these specialties.
  • 2015 Springer
    Stefano La Rosa, Fausto Sessa, editors.
  • 2015 Springer
    Nicola J. Curtin, Ricky A. Sharma, editors.
    History of the discovery of poly (ADP-ribose) -- Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members -- The role of PARPs in DNA Strand Break Repair -- TIPs: Tankyrase Interacting Proteins -- PARP and Carcinogenesis -- Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity -- Overview of PARP Inhibitor Design and Optimization -- Structure Based Design of PARP Inhibitors -- Preclinical chemosensitization by PARP inhibitors -- Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents -- Radiosensitisation by poly(ADP-ribose) polymerase inhibition -- The vasoactivity of PARP inhibitors -- Synthetic lethality with Homologous Recombination Repair defects -- Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality -- Other determinants of sensitivity -- Synthetic sickness with molecularly targeted agents against the EGFR pathway -- Disruption of DNA repair by cell cycle and transcriptional CDK inhibition -- Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations -- PARP inhibitor resistance -- what is beyond BRCA1 or BRCA2 restoration -- Introduction to PARPi clinical trials and future directions -- Clinical trials investigating PARP inhibitors as single agents -- Clinical trials of PARP inhibitors with chemotherapy -- Combination of PARP inhibitors with clinical radiotherapy -- Biomarkers for PARP Inhibitors.
  • 2016 Springer
    Arabinda Kumar Rath, Narayan Sahoo, editors.
    Particle Therapy in the Third Millennium Current Status and Future Outlook -- Development of Cyclotrons for Proton and Particle Therapy -- Development of C-ion Radiotherapy Technologies in Japan -- Physical rationale for protontherapy and elements to build a clinical center -- Radiation Dosimetry of Proton Beams -- Clinical pencil beam scanning: present and future practices -- Treatment planning for protons -- An essay.- Radiation Therapy with Protons and Heavy Ions -- Robustness Quantification and Worst-Case Robust Optimization in Intensity-Modulated Proton Therapy -- Modeling of Biological Effect of Charged Particles for C-Ion RT -- SFUD, IMPT and plan robustness.
  • 2013 Springer
    Stephen T. Sonis, Dorothy M. Keefe, editors.
  • 2014 Springer
    Tim D. Oury, Thomas A. Sporn, Victor L. Roggli, editors.
    The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, and analysis of tissue mineral fiber content. In addition, the medicolegal issues relating to asbestos-associated diseases are analyzed from the point of view of both the plaintiff and the defendant. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.
  • 2015 Springer
    Christopher R. Shea, Jon A. Reed, Victor G. Prieto, editors.
    Part I: Introductory Chapters -- Chapter 1. Gross Prosection of Melanocytic Lesions -- Chapter 2. Histopathologic Staging and Reporting of Melanocytic Lesions -- Chapter 3. Clinicopathologic Correlation in Melanocytic Lesions -- Chapter 4. Anathema or Useful? Application of Immunohistochemistry to the Diagnosis of Melanocytic Lesions -- Chapter 5. Applications of Additional Techniques to Melanocytic Pathology -- Part 2: Diagnostic Challenges -- Chapter 6. Spitz Nevus versus Spitzoid Melanoma -- Chapter 7. Halo Nevus versus Melanoma with Regression -- Chapter 8. Nevoid Malignant Melanoma versus Melanocytic Nevus -- Chapter 9. Dysplastic Nevi versus Melanoma -- Chapter 10. Blue Nevus versus Pigmented Epithelioid Melanocytoma -- Chapter 11. Recurrent Melanocytic Nevus versus Melanoma -- Chapter 12. Neurothekeoma versus Melanoma -- Chapter 13. Melanoma in situ versus Paget?s Disease -- Chapter 14. Desmoplastic Nevus versus Desmoplastic Melanoma -- Chapter 15. Cutaneous Metastatic Melanoma versus Primary Cutaneous Melanoma -- Chapter 16. Acral Nevus versus Acral Melanoma -- Chapter 17. Capsular (Nodal) Nevus versus Metastatic Melanoma -- Index.
  • 2006 Springer
    [edited by] Françoise Galateau-Sallé.
    Epidemiology of Mesothelioma -- Molecular Biology -- Serosal Anatomy and Anatomic Distribution of Mesothelioma -- Clinical Aspects of Mesothelioma -- Management of Malignant Serosal Effusions -- Pathologic Diagnosis and Classification of Mesothelioma -- Macroscopic Features of Mesotheliomas -- Classification and Histologic Features of Mesotheliomas -- Differential Diagnosis: Mesothelial Proliferations -- Differential Diagnosis: Other Mesothelial Lesions -- Differential Diagnosis: Nonmesothelial Lesions -- Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas -- Differential Diagnosis: Other Nonmesothelial Tumors.
  • 2014 Springer
    Raymond L. Barnhill, editor-in-chief ; Michael W. Piepkorn, Klaus J. Busam, co-editors.
    Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated withthe aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.
  • 2016 Springer
    Maurizio Colecchia, editor.
    This user-friendly book is a practical guide to the diagnosis of testicular tumors and rare tumors of the penis. It describes and illustrates pathology findings for each tumor type and provides information on clinical features, differential diagnosis, tumor staging, and prognostic factors. Since an effective dialogue between urologists and pathologists is essential for optimal patient care, due attention is paid to such aspects as the role of frozen section in the management of small testicular nodules and the accurate reporting of testicular and penile neoplasms to ensure that all knowledge required for diagnostic and therapeutic decision-making is available. The key information is presented in straightforward tables for ease of reference. This book, which includes more than 250 full-color photos, is not only a valuable resource for surgical pathologists and pathology residents but also an important reference tool for all clinicians who care for patients with genitourinary tract tumors. .
  • 2014 Springer
    Nafisa Wilkinson, editor.
    As the second volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists, Pathology of the Ovary, Fallopian Tube and Peritoneum is one of the very few dealing wholly with this subject. Pathology of the Ovary, Fallopian Tube and Peritoneum introduces the topic with a discussion of the anatomy, development, histology and normal function of the ovary, followed by chapters on non-neoplastic disorders of the ovary; surgery and medical management of ovarian cancer; and the use of imaging, frozen sections and cytology in ovarian pathology. The book then goes on to describe specific disorders of the ovary, fallopian tube and peritoneum in detail, and finishes with a chapter on specimen cut-up. Pathology of the Ovary, Fallopian Tube and Peritoneum has been written to be useful diagnostically to general as well as specialist gynecological histopathologists and pathologists in training. Gynecologists, oncologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.
  • 2013 Springer
    editors, Frank E. Johnson, Yoshihiko Maehara, George P. Browman, Julie A. Margenthaler, Riccardo A. Audisio, John F. Thompson, David Y. Johnson, Craig C. Earle, Katherine S. Virgo/
    Patient Surveillance After Cancer Treatment covers the history of cancer patient surveillance after curative-intent treatment, the rationale, the methodologies used in the past and at present, the methodologies that will probably emerge in the future, the costs of surveillance, the definitions of various terms used in the field, and how those who are interested in the topic can get more information about it from the internet. The secondary focus of the book is to publicize the need for well-designed, adequately powered randomized clinical trials comparing two (or more) surveillance strategies for each type of cancer.The audience includes all oncologists, cancer researchers, medical economists and policy makers in government and insurance companies, and finally, interested patients.This book is part of the Current Clinical Oncology series, which provides cutting-edge knowledge of cancer diagnosis, management, and treatment. World renowned experts share their insights in all the major fields of clinical oncology. From the fundamentals of pathophysiology to the latest developments in experimental and novel therapies, Current Clinical Oncology is an indispensable resource for today's practicing oncologist.
  • 2009 Springer
    edited by Norman Jaffe, Øyvind S. Bruland, Stefan Bielack.
    Also available: Print – 2009
  • 2006 Springer
    Alberto S. Pappo (ed.).
    Also available: Print – 2006
  • 2009 Springer
    editors, José Cañadell, Mikel San-Julian ; foreword by Franklin H. Slim.
  • v. 1-, 2012- Springer
    Hayat, M. A.
  • v. 3-4, 2012-13. Springer
    v. 4 Springer
    edited by M.A. Hayat.
  • v. 2, 2012 Springer
    edited by M.A. Hayat.
  • 2014 Springer
    Derek S. Wheeler, Hector R. Wong, Thomas P. Shanley, editors.
    The Editors and contributors of this book take seriously the statement that 'For all of the science inherent in the specialty of pediatric critical care medicine, there is still art in providing comfort and solace to our patients and their families. No technology will ever replace the compassion in the touch of a hand or the soothing words of a calm and gentle voice.' The four volumes of Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition detail the continued growth and evolution of the pediatric critical care medicine speciality. They reveal the technological innovations in monitoring and information management and gives witness to the rapid evolution and adoption of novel monitoring techniques, such as continuous venous oximetry and near-infrared spectroscopy. They also cover advances in molecular biology that have led to the era of personalized medicine with the ability to individualize treatment to the unique and specific needs of a patient. As such this volume and its three sister titles will be of immense value to all studying and practicing pediatric critical care medicine or those involved in the management of this group of patients.
  • 2014 Springer
    A. Lindsay Frazier, James F. Amatruda, editors.
    Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.
  • 2014 Springer
    Reza Rahbar, Carlos Rodriguez-Galindo, John G. Meara, Edward R. Smith, Antonio R. Perez-Atayde, editors.
    The pediatric head and neck cancer patient necessitates a multidisciplinary team of specialists to provide an optimal continuum of care. This A-Z guide provides practical, in-depth information for all medical professionals involved in the evaluation and treatment of these patients. Written in an easy to follow format, each entry contains illustrative figures to aid in pathological and radiographical diagnosis, as well as structured discussion of evaluation and multimodality management. The alphabetical layout eliminates redundancy and allows the busy physician to quickly locate relevant information. Pediatric Head and Neck Tumors is ideal for young physicians as well as attending physicians seeking to expand their knowledgebase to the various subspecialties involved in the multidisciplinary care of their patients.
  • 2014 Springer
    Daniela Cristina Stefan, Carlos Rodriguez-Galindo, editors.
    Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.
  • 2007 Springer
    Howard J. Weinstein, Melissa M. Hudson, Michael P. Link (eds.).
    Introduction and historical background: pediatric Hodgkin lymphoma -- Biology and pathology of Hodgkin's disease -- Treatment of pediatric Hodgkin lymphoma -- Treatment of relapsed/refractory Hodgkin lymphoma -- Non-Hodgkin's lymphoma: introduction and historical background -- Biology and pathology of pediatric non-Hodgkin lymphoma -- B-cell lymphoma/ Burkitt lymphoma -- Anaplastic large-cell lymphoma -- Precursor B and precursor T-cell lymphoblastic lymphoma -- Cutaneous T-cell lymphomas and rare T-cell non-Hodgkin lymphomas -- Lymphoproliferative disorders related to immunodeficiencies -- Late effects following lymphoma treatment.
  • 2015 Springer
    David M. Parham, Joseph D. Khoury. M. Beth McCarville, editors.
    Pediatric Malignanies: Pathology and Imaging serves as a state-of-the-art reference for understanding the fundamental biology and diagnostic aspects of pediatric tumors. This volume stands apart from other books covering pediatric neoplasia by providing an in-depth analysis of the pathogenetic and diagnostic aspects of the most commonly encountered tumors. The volume covers the new advances in our understanding of the molecular processes underlying a number of pediatric tumors and the novel, sophisticated diagnostic tools that have now become an integral part of practice standards. Pediatric Malignanies: Pathology and Imaging will be of great value for practicing clinicians, oncologists, radiologists, surgeons, pediatricians and pathologists for characterizing and diagnosing childhood tumors.
  • 2012 Springer
    Alexander Craig Mackinnon, Jr., editor.
    Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
  • 2015 Springer
    Katrin Scheinemann, Eric Bouffet, editors.
    1. Introduction -- 2. Epidemiology of pediatric brain tumors -- 3. Clinical signs and symptoms of pediatric brain tumors -- 4. Neuro-imaging -- 5. Neuro-surgery -- 6. Low grade glioma -- 7. High grade glioma -- 8. Medulloblastoma/ PNET -- 9. Ependymoma -- 10. Germ cell tumors -- 11. ATRT -- 12. Craniopharyngeoma -- 13. Rare brain tumors (CPP, CPC etc.) -- 14. Infant brain tumors -- 15. Radiotherapy -- 16. Chemotherapy -- 17. Targeted treatment -- 18. Long term sequelae -- 19. Neurocognitive outcome -- 20. Quality of life -- 21. Palliative care -- 22. Cancer syndromes -- 23. Brain tumor stem cells -- 24. Pediatric neurooncology in developing countries -- 25. Neuropathology 26. HDCT/ ASCT -- 27. Developmental neurobiology -- 28. Basic science of pediatric brain tumors.
  • 2005 Springer
    Ka Wah Chan and R. Beverly Raney Jr., editors ; foreword by Eugenie S. Kleinerman.
    Acute Leukemia / Michael E. Rytting, Mary S. Choroszy, Demetrios Petropoulos and Ka Wah Chan -- Hodgkin Lymphoma and Non-Hodgkin Lymphoma / Ka Wah Chan, Demetrios Petropoulos, Eric L. Chang and Michael E. Rytting -- Brain Tumors: Diagnosis, Surgery and Radiotherapy, and Supportive Care / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, Bartlett D. Moore and Donna R. Copeland -- Brain Tumors: Chemotherapy and Investigational Therapy / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor and Demetrios Petropoulos -- Wilms' Tumor / Norman Jaffe and Margaret G. Pearson -- Neuroblastoma / Joann L. Ater and Laura L. Worth -- Soft-Tissue Tumors / R. Beverly Raney, Richard J. Andrassy, Martin Blakely, Tina V. Fanning and Moshe H. Maor, et al. -- Osteosarcoma / Norman Jaffe and Margaret G. Pearson -- Ewing's Sarcoma / Cynthia E. Herzog, Anita Mahajan and Valerae O. Lewis -- Retinoblastoma / Misha Faustina, Cynthia E. Herzog and Dan S. Gombos -- Differentiated Thyroid Cancer / Rena Vassilopoulou-Sellin -- Medullary Thyroid Carcinoma / Robert F. Gagel -- Melanoma / Cynthia E. Herzog, Hafeez Diwan, Merrick I. Ross and Victor G. Prieto -- Novel Therapeutic Approaches / Sima S. Jeha and Laura L. Worth -- Supportive Care: Myelosuppression / Nidra I. Rodriguez Cruz, Renee M. Madden and Craig A. Mullen -- Supportive Care: Symptom Control / Renee M. Madden, Susannah E. Koontz-Webb, Donna S. Zhukovsky and Craig A. Mullen -- Behavioral Medicine in Cancer Care / Donna R. Copeland and Martha A. Askins -- The Adolescent and Young Adult Program / Sima S. Jeha and Martha A. Askins.
  • 2011 Springer
    Paul Imbach, Thomas Kühne, Robert Arceci, editors.
  • 2014 Springer
    Paul Imbach, Thomas Kuehne, Robert Arceci, eds.
    General Aspects of Childhood Leukemia -- Acute Lymphoblastic Leukemia -- Acute Myeloid Leukemia -- Myelodysplastic Syndrome -- Myeloproliferative Neoplasms -- Non-Hodgkin Lymphoma -- Hodgkin Disease -- Histiocytoses -- Brain Tumors -- Neuroblastoma -- Renal Tumors -- Soft Tissue Sarcomas -- Osteosarcoma -- Ewing Sarcoma Family of Tumors -- Retinoblastoma -- Germ Cell Tumors -- Hepatic Tumors -- Rare Tumors -- Emergencies in Pediatric Oncology -- Oncological Nursing Care -- Psychology and Psychosocial Issues in Children with Cancer.
  • 2010 Springer
    Deborah Tomlinson, Nancy E. Kline, eds.
  • 2016 Springer
    Anna N. Abrams, Anna C. Muriel, Lori Wiener, editors.
    Overview of Pediatric Oncology -- Communication -- Physical Impact of the Disease -- Assessment/Coping/Quality of Life -- Family Systems -- Psychiatric issues and treatment -- Education -- Adolescents -- Social Media -- Complementary Therapies -- End of Life Care -- Survivorship -- Advocacy.
  • 2011 Ovid
    Edward C. Halperin ... [et al.].
    "Pediatric Radiation Oncology is the definitive text and reference on use of radiation therapy for childhood cancer. The fifth edition reviews all significant recent clinical trials--including, for the first time, significant European clinical trials--and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer"--Provided by publisher.
  • 2005 Ovid
    [edited by] Edward C. Halperin, Louis S. Constine, Nancy J. Tarbell ... [et al.].
    Also available: Print – 2005
  • 2013 CRCnetBASE
    Arthur J. Olch.
    Overview of childhood cancer : incidence, survival, and late effects -- Challenges of treating children with radiation therapy -- Leukemia -- Tumors of the central nervous system -- Hodgkin lymphoma -- Neuroblastoma -- Wilms' tumor -- Soft-tissue tumors : (rhabdomyosarcoma and other soft-tissue sarcomas) -- Bone sarcomas (osteosarcoma and Ewing's sarcoma) -- Retinoblastoma.
  • 2013 Springer
    Philippe E. Spiess, editor ; foreword by Francesco Montorsi.
    Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer. The book also addresses many of the novel diagnostic and therapeutic surgical appro
  • 2011 Thieme Book
    [edited by] Kelvin Hong, Christos S. Georgiades.
    Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology.
  • 2008 Springer
    T.J. Vogl ... [et al.], eds ; with contributions by A. Boss ... [et al.] ; foreword by A.L. Baert.
  • 2013 Ovid
    editors, Edward C. Halperin, David E. Wazer, Carlos A. Perez, Luther W. Brady.
    "Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book's comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with acompletely revamped digital experience, powered by Inkling! NEW to the Sixth Edition ... site-specific chapters include relevant background information on each tumor including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more. Over 1,400 full-color illustrationshighlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy. Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy. Greater emphasis on palliative and supportive carereflects the role of radiation treatment in non-curative roles. New editors and contributors let you benefit from their decades of experience. Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more."
  • 2008 Ovid
    editors, Edward C. Halperin, Carlos A. Perez, Luther W. Brady ; associate editors, David E. Wazer, Carolyn Freeman, Leonard R. Prosnitz.
    The discipline of radiation oncology -- Biologic basis of radiation therapy -- Molecular cancer and radiation biology -- Molecular pathophysiology of tumors -- Principles of radiologic physics, dosimetry, and treatment planning -- Photon external-beam dosimetry and treatment planning -- Electron-beam therapy: dosimetry, planning, and techniques -- Three-dimensional conformal radiation therapy: physics, treatment planning, and clinical aspects -- Intensity-modulated radiation treatment techniques and clinical applications -- Image-guided radiation therapy -- Altered fractionation schedules -- Late effects of cancer treatment on normal tissues -- Methodology of clinical trials -- Total-body and hemibody irradiation -- Stereotactic radiosurgery and radiotherapy -- Sterotatic irradiation of tumors outside the central nervous system -- Intraoperative radiotherapy -- Particle beam radiotherapy -- Physics and biology of brachytherapy -- Clinical applications of brachytherapy: low-dose-rate and pulse-dose-rate -- The physics and dosimetry of high-dose-rate brachytherapy -- Clinical aspects and applications of high-dose-rate brachytherapy -- Radioimmunoglobulins and nonsealed radionuclide therapy -- Photodynamic therapy -- Radiation oncology in the developing world -- Chemical modifiers of radiation response -- Oncologic imaging/oncologic anatomy -- Hyperthermia -- Basic concepts of chemotherapy and irradiation interaction -- Skin -- Malignant neoplasms associated with the acquired immunodeficiency syndrome -- Primary intracranial neoplasms -- Pituitary -- Spinal canal -- Eye and orbit -- Ear -- The role of combined radiotherapy and chemotherapy in the management of locally advanced squamous carcinoma of the head and neck -- Nasopharynx -- Nasal cavity and paranasal sinuses -- Salivary glands -- Oral cavity cancer -- Oropharynx -- Hypopharynx cancer -- Larynx -- Unusual nonepithelial tumors of the head and neck -- Management of the neck including unknwon primary tumor -- Thyroid -- Lung -- Mediastinum and trachea -- Esophageal cancer -- Tumors of the heart and great vessels -- Breast: stage tis -- Early stage breast cancer -- Breast cancer: locally advanced and recurrent disease, postmastectomy radiation, and systemic therapies -- Stomach -- Cancer of the pancreas -- Liver and hepatobiliary tract -- Colon and rectum -- Anal cancer -- Kidney, renal pelvis, and ureter -- Bladder -- Low-risk prostate cancer -- Intermediate- and high-risk prostate cancer -- Testis -- Penis and male urethra -- Uterine cervix -- Endometrium -- Ovary -- Fallopian tube -- Vagina -- Female urethra -- Carcinoma of the vulva -- Retroperitoneum -- Adrenal gland -- Hodgkin lymphoma -- Non-Hodgkin's lymphoma -- Cutaneous T-cell lymphoma -- Leukemia -- Plasma cell myeloma and plasmacytoma -- Osteosarcoma -- Soft tissue sarcomas (excluding retroperitoneum) -- Central nervous system tumors in children -- Wilms' tumor -- Neuroblastoma -- Rhabdomyosarcoma -- Ewing tumor -- Lymphomas in children -- Unusual tumors in childhood -- Radiotherapy of non-malignant diseases -- Endovascular brachytherapy -- Palliation of brain and spinal cord metastases -- Palliation of bone metastases -- Palliation of visceral recurrences and metastases -- Pain management -- Supportive care and quality of life -- Technology assessment, cost benefit, outcome analysis research and evidence-based radiation oncology -- Ethics, professional values, and legal considerations in radiation oncology -- The economics of radiation oncology.
  • 2007 Springer
    edited by Wim P. Ceelen.
    Also available: Print – 2007
  • 2015 Springer
    Emel Canbay, Yutaka Yonemura.
    1. Anatomy of Peritoneum and Preoperative Assessment of Patients with Peritoneal Surface Malignancies -- 2. Surgical Technique for Cytoreductive Surgery -- 3. Intraperitoneal Chemotherapy Applications -- 4. Management of Special Issues -- 5. Molecular Mechanism of Peritoneal Metastases.
  • 2012 Ovid
    editor, Michael C. Perry ; associate editors, Donald C. Doll, Carl E. Freter.
    Scientific basis of cancer chemotherapy -- Norton-Simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Intraarterial chemotherapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of cancer therapeutics -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of chemotherapeutic agents -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Chemotherapy-induced renal and electrolyte dysfunction -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- Chemotherapy of primary brain tumors -- Chemotherapy for head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestional cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancer -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy for childhood leukemia -- Chemotherapy of Hodgkin lymphoma -- Non-Hodgkin lymphoma -- Chronic lymphocytic leukemia -- Acute myeloid leukemia -- Myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma -- Appendics: I: Chemotherapeutic agents -- II: Chemotherapy programs -- III: Common terminology criteria for adverse events (CTCAE) version 4.0.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

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MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

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