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OncologyAccess restricted to Stanford unless otherwise noted

  • Epidemiology of IGF-1 and cancer / Katharina Nimptsch and Eward Giovannucci -- Aging and cancer : the IGF- I connection / Kalina Biernacka, Claire Perks, and Jeff Holly -- Obesity, type 2 diabetes and cancer / Rosalyn D. Ferguson and Derek LeRoith -- IGF system and breast cancer / Marc A. Becker and Douglas Yee -- The role of insulin-like growth factor signaling in prostate cancer development and progression / Bruce Montgomery, James Dean, and Stephen Plymate -- IGF-1 cellular action and its relationship to cancer : evidence from in vitro and in vivo studies / Rosalyn D. Ferguson ... [et al.] -- Insulin-like growth factor signaling in pediatric sarcomas / Xiaolin Wan, Su Young Kim, and Lee J. Helman -- Cancer genes, tumor suppressors, and regulation of IGF1-R gene expression in cancer / Haim Werner ... [et al.] -- Mouse models of IGF-1R and cancer / Craig I. Campbell, James J. Petrik, and Roger A. Moorehead -- Targeting the insulin-like growth factor-I receptor in cancer therapy / David R. Clemmons -- Targeting insulin-like growth factor receptor 1 (IGF-1R) and insulin receptor signaling by tyrosine kinase inhibitors in cancer / Joan M. Carboni, Mark Wittman, and Fei Huang -- Calories and cancer : the role of insulin-like growth factor-1 / Stephen D. Hursting ... [et al.] -- Cancer cell metabolism / Akash Patnaik, Jason W. Locasale, and Lewis C. Cantley -- Overlaps between the insulin and IGF-I receptor and cancer / Antonino Belfiore and Roberta Malaguarnera.
  • Microenvironmental effects on tumour progression and metastasis -- Role of microenvironment on gene expression, angiogenesis and microvascular function in tumors -- Imaging of angiogenesis in vivo with fluorescent proteins -- The epigenetic influence of the tumor microenvironment on melanoma plasticity -- Dynamics of cell adhesion interactions during melanoma development -- Matrix metalloproteinases: mediators of tumour-host cell interactions -- Role of brain microenvironments in brain metastases -- Influence of the bone microenvironment on breast cancer metastasis to bone -- Interaction of tumour with host stroma in hepatocellular carcinoma -- Dynamic nature of tumour-host interactions within the tumor microenvironment -- Breast cancer progression: a "vicious cycle" of pro-malignancy activities is mediated by inflammatory cells, chemokines and cytokines -- Tumor and host endothelial cell selective interactions and modulation by microenvironmental chemokines: tumor-endothelial cell cross talk specificity -- The role of chemokine receptors, in particular CXCR4, in lymphoma and carcinoma metastasis --Energy homeostasis and the tumor/host interaction: the role of the brain -- Anti-angiogenic and pro-apoptotic effects of dietary restriction in experimental brain cancer: role of glucose and ketone bodies -- Dietary restriction of specific amino acids modulates tumor and host interactions -- Role of tumour microenvironment in chemoresistance -- Integrin-mediated resistance to chemotherapy-induced apoptosis in cancer cells -- Bone metastasis microenvironment participates in the development of androgen ablation refractoriness and chemotherapy resistance of prostate cancer cells residing in the skeleton: clinical implications -- Current and future therapeutic targets of the tumour-host microenvironment -- Bone stromal cells as therapeutic targets in osseous metastasis -- Organtropism of lung cancer metastasis and its molecular targeted therapy -- Maspin: a novel serine protease inhibitor -- Metastasis suppressor genes: a brief review of an expanding field -- Tumor-host interactions at the metastatic site: MKK4, signal transduction and the stress response.
  • Integrative oncology 2008, Springer
    Introduction -- A word of caution: risk of harm associated with alternative complementary/integrative approaches in cancer management and the critical need for quality research to understand and decrease that risk -- Using legal and ethical principles to guide clinical decision making in complementary/integrative cancer medicine -- Communicating with patients about the use of complementary and integrative medicine in cancer care -- The integrative medicine program at The University of Texas M. D. Anderson Cancer Center -- The integrative medicine service at Memorial Sloan-Kettering Cancer Center -- Integrative oncology-Leonard P. Zakim Center: the Dana-Farber Cancer Institute experience -- The Johns Hopkins complementary and integrative medicine service -- Integrative oncology at Mayo Clinic: research informing practice -- Mind-body research in cancer -- Herbs and other botanicals: interactions with pharmaceuticals -- Acupuncture in cancer care at Dana-Farber Cancer Institute: an integrative medical practice -- Acupuncture for the side effects of cancer treatments.
  • This practice-oriented handbook covers complementary and alternative medicine (CAM) practices in pediatric oncology worldwide, with a focus on methods used in Western countries. Provides a road map for establishing integrative pediatric oncology worldwide.
  • Prostate brachytherapy has been the subject of heated debate among surgeons and the proponents of the various brachytherapy methods. This very first interdisciplinary book on the subject provides a comprehensive overview of innovations in low dose rate (LDR), high dose rate (HDR), and pulsed dose rate (PDR) interstitial brachytherapy for the management of local or locally advanced prostate cancer. In addition to detailed chapters on patient selection and the use of imaging in diagnostics, treatment guidance, and implantation control, background chapters are included on related medical physics issues such as treatment planning and quality assurance. The results obtained with the different treatment options and the difficult task of salvage treatment are fully discussed. All chapters have been written by internationally recognized experts in their fields who for more than a decade have formed the teaching staff responsible for the successful GEC-ESTRO/EAU Prostate Brachytherapy Teaching Course. This book will be invaluable in informing residents and others of the scientific background and potential of modern prostate brachytherapy. It will also prove a useful source of up-to-date information for those who specialize in prostate brachytherapy or intend to start an interstitial brachytherapy service.
  • Interventional oncology 2012, Springer
  • The Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice.The series comprises a number of titles, which cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, ablation, pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice.Interventional Radiology Techniques in Ablation is a practical and concise guide to contemporary techniques in image-guided tumor ablation. This handbook is intended to serve as a quick reference for physicians in interventional radiology training as well as a resource for IR technologists, nurses, nurse practitioners and physician assistants.
  • Interventions in Pulmonary Medicine is an important new volume that addresses all areas of interventional pulmonology, a minimally invasive endoscopic way to diagnose and treat lung disorders. This volume contains dedicated chapters that outline the many issues related to lung cancer, both in early and advanced stages, from diagnosis to personalized treatment. It also covers bronchoscopic therapeutic options to benign conditions that are highly prevalent, such as COPD and asthma. Techniques described in this volume are: laser therapy, argon plasma coagulation therapy, cryotherapy, brachytherapy, placement of intrapleural drainage systems, endoscopic treatment of emphysema, stents in the airway, and thermoplasty for bronchial asthma. Diagnostic procedures that are covered are: medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, electromagnetical navigation, and trends in personalized treatment for lung cancer and other benign lung conditions. Chapters are written by experts and the developers of the techniques that are currently considered gold standard. Evidence-based reviews are presented for all topics and indications, and contraindications are discussed. Interventions in Pulmonary Medicine is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.
  • Intraductal papillary mucinous neoplasms (IPMNs) represent an opportunity to treat pancreatic tumors before they develop into aggressive, hard-to-treat cancers. Beginning with morphological classification and its clinical significance, natural history, and malignant change of both main duct and branch duct IPMNs, this book covers the whole field of IPMNs of the pancreas. It reviews the various methods of investigation: imaging, diagnostic investigation of cyst fluid, and those using pancreatic juice; and also examines aspects ranging from the development of malignancy to the timing and method of resection, focusing on both main duct and branch duct IPMNs. Aimed at residents, clinical fellows, and pancreatologists who treat patients with this common disease of the pancreas, this book is a landmark in the current understanding and future perspectives of IPMNs of the pancreas.
  • Management of ovarian cancer : the theory / Maurie Markman -- Management of ovarian cancer : clinical trials / Maurie Markman -- A systematic review and meta-analysis of randomized trials / Kenneth Jaaback -- Immunobiology and intraperitoneal immunobiologics in ovarian cancer / Ralph S. Freedman -- Intraperitoneal chemotherapy : technique and complications / Joan L. Walker -- Hyperthermia and chemotherapy : the science / Roger A. Vertrees, Jeffrey M. Jordan, and Joseph B. Zwischenberger -- Hyperthermic intraperitoneal chemotherapy in nongynecologic cancers / Bing Yi, Jason M. Foster, and Brian W. Loggie -- Peritoneal carcinomatosis of colorectal origin / Frans A.N. Zoetmulder -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : experience in France / Olivier Glehen and Francois-Noel Gilly -- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian cancer : world experience / C. William Helm -- Techniques of delivering hyperthermic intraperitoneal chemotherapy / Jesus Esquivel, Paul H. Sugarbaker, and C. William Helm -- Future directions in the delivery of hyperthermic intraperitoneal chemotherapy / Scott Richard and Robert P. Edwards.
  • Current chemotherapy of ovarian cancer -- Principles of intraperitoneal chemotherapy -- Intraperitoneal chemotherapy: phase III trials -- Criteria for using intraperitoneal (IP) chemotherapy for advanced ovarian cancer -- Selection and placement of intraperitoneal catheters for IP chemotherapy for ovarian cancer -- Selection of drugs for intraperitoneal chemotherapy for ovarian cancer -- Administration guidelines for intraperitoneal chemotherapy for ovarian cancer -- Novel drugs for intraperitoneal therapy for ovarian cancer -- Cytoreductive surgery and perioperative intraperitoneal chemotherapy: an ongoing research effort -- Health-related quality of life and patient-reported outcomes.
  • Invasive bladder cancer 2007, Springer
  • Invasive cytopathologist 2014, Springer
    Chapter 1. Ultrasound, general considerations -- Chapter 2. The interventional cytopathologist -- Chapter 3. The thyroid gland -- Chapter 4. The parathyroid gland -- Chapter 5. The salivary glands -- Chapter 6. The head and neck, miscellaneous lesions -- Chapter 7. The lymph nodes -- Chapter 8. The breast -- Index.
  • The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical Reviews in Toxicology. Part 1 contains the IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans, along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analyzing the Relevance of a Non-Cancer Mode of Action for Humans. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
  • Kidney cancer 2012, Springer
  • Killer lymphocytes 2005, Springer
  • Kinetochore 2009, Springer
    Centromeres and kinetochores : an historical perspective /Kerry S. Bloom --The basics of chromosome segregation /Mitsuhiro Yanagida --The centromere /Beth A. Sullivan --Neocentromeres /Owen J. Marshall and K.H. Andy Choo --Human artificial centromeres : de novo assembly of functional centromeres on human artificial chromosomes /Hiroshi Masumoto, Teruaki Okada, and Yasuhide Okamoto --Kinetochore composition, formation, and organization /Tatsuo Fukagawa and Peter De Wulf --Evolution of centromeres and kinetochores : a two-part fugue /Paul B. Talbert, Joshua J. Bayes, and Steven Henikoff --Mitotic spindle assembly mechanisms /Rebecca Heald and Claire E. Walczak --Kinetochore-microtubule interactions /Lesley Clayton and Tomoyuki U. Tanaka --Post-translational modifications that regulate kinetochore activity /Chitra V. Kotwaliwale and Sue Biggins --The role of the kinetochore in spindle checkpoint signaling /P. Todd Stukenberg and Daniel J. Burke --Kinetochore regulation of anaphase and cytokinesis /Scott Thomas and Kenneth B. Kaplan --Roles of centromeres and kinetochores in meiosis /Adele L. Marston --The kinetochore-cancer connection /Takeshi Tomonaga --The kinetochore as target for cancer drug development /Song-tao Liu and Tim J. Yen.
  • "Written by an internationally recognized multidisciplinary team of authors, Kuerer's Breast Surgical Oncology is the first text specifically dedicated to breast surgical oncology. ... Kuerer's examines all clinically relevant knowledge in the field, from the pathology of the breast and clinical management, to follow-up and complications following diagnosis and therapy. The book also focuses on the next wave of molecular studies that represent the future of the discipline."--BOOK JACKET.
  • Part I. Overview of brain tumor survivorship -- Introduction to brain tumor survivorship and historical perspective / Stewart Goldman and Christopher D. Turner -- Late effects of neurosurgery / Arthur J. DiPatri, Martin Pham, and Kenji Muro -- Late effects of CNS radiation therapy / Helen A. Shih, Jay S. Loeffler, and Nancy J. Tarbell -- Late effects of chemotherapy / Sridharan Gururangan -- Late effects of stem cell transplantation in brain tumor survivors / Karina Danner-Koptik, David A. Jacobsohn, and Kimberley J. Dilley -- Effect of cancer treatment on neural stem and progenitor cells / Jörg Dietrich and Santosh Kesari -- The pediatric brain tumor late effects clinic / Kimberly J. Dilley and Barbara Lockart -- Part II. Medical late effects of brain tumor treatment -- Neurological complications in adults / Michelle Monje and Patrick Y. Wen -- Neurological complications in children / Sonia Partap and Paul Graham Fisher -- Strokes among childhood brain tumor survivors / Daniel C. Bowers -- Endocrine late effects: manifestations and treatments / Jason R. Fangusaro and Elizabeth Eaumann Littlejohn -- Ocular consequences and late effects of brain tumor treatments / María E. Echevarría and Joanna L. Weinstein -- Auditory late effects of chemotherapy / Anna K. Meyer and Nancy M. Young -- Reproductive health issues in survivors of childhood and adult brain tumors / Tress Goodwin, B. Elizabeth Delasobera, and Paul Graham Fisher -- Cancer predisposition syndromes / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral -- Secondary neoplasms following treatment for brain tumors / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral.
  • Leukaemia 2003, Wellcome Trust
  • Leukemia 2009, Springer Protocols
    An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia / C.W. So -- Backtracking of leukemic clones to birth / J. Wiemels, M. Kang and M. Greaves -- Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia / Z.J. Konn ... [et al.] -- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research / L. Kearney and S. Colman -- LDI-PCR: identification of known and unknown gene fusions of the human MLL gene / C. Meyer and R. Marschalek -- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences / B.W. Robinson and C.A. Felix -- MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR / V.H. van der Velden and J.J. van Dongen -- Array-based comparative genomic hybridization as a tool for analyzing the leukemia genome / J.C. Strefford and H. Parker -- Application of SNP genotype arrays to determine somatic changes in cancer / M. Gupta and B.D. Young -- Retroviral/Lentiviral transduction and transformation assay / B.B. Zeisig and C.W. So -- Gene expression profiling of leukemia stem cells / A.V. Krivtsov ... [et al.] -- Humanized model to study leukemic stem cells / D. Bonnet -- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction / M. Wunderlich and J.C. Mulloy -- Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells / J.J. Schuringa and H. Schepers -- Identification and characterization of hematopoietic stem and progenitor cell populations in mouse bone marrow by flow cytometry / J. Yeung and A.C. Wai Eric So -- In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development / P. Sroczynska ... [et al.] -- Analysis of the mouse placenta as a hematopoietic stem cell niche / K. Ottersbach and E. Dzierzak -- Identification of protein interaction partners by the yeast two-hybrid system / M.P. Garcia-Cuellar, D. Mederer and R.K. Slany -- Complete array of HOX gene expression by RQ-PCR / G.J. Dickson, T.R. Lappin and A. Thompson -- Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias / M.E. Figueroa, A. Melnick and J.M. Greally -- Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins / T.A. Milne, K. Zhao and J.L. Hess.
  • Artificial light and human temporal organization. Artificial light and its physiochemical properties -- Light and dark cycles as a basis of temporal organization -- Biological clock and its entrainment by photoperiod -- Light at night (LAN) exposure and its potential effects on daily rhythms and seasonal disruptions -- Melatonin : "hormone of darkness" and a "Jack of all traits" -- Light pollution, its known health effects and impact on energy conservation. Introduction and spread of artificial illumination : a human history retrospective -- Biological definition of light pollution -- Light-at-night (LAN) as a general stressor -- Effects of light pollution on animal daily rhythms and seaonality : ecological consequences -- Light polluiton and hormone-dependent cancers : a summary of accumulated empirical evidence -- Light pollution and its potential links to breast and prostate cancers. Geographic patterns of breast and prostate cancers (BC&PC) worldwide -- Light pollution and its associations with BC&PC in population-level studies -- Selected methodological issues of LAN-BC&PC reserach -- Dark-less world : what is next? (conclusions and prospects for future research).
  • Inflammation and cancer: the role of the immune response and angiogenesis /Angus G. Dalgleish and Ken O'Byrne --Chronic inflammation and pathogenesis of GI and pancreatic cancers /Lindsey N. Jackson and B. Mark Evers --Cytokines, NF-[kappa]B, microenvironment, intestinal inflammation and cancer /Arndt J. Schottelius and Harald Dinter --Regulation of NF-[kappa]B transcriptional activity /Linda Vermeulen, Wim Vanden Berghe and Guy Haegeman --The role of immune cells in the tumor microenvironment /Theresa L. Whiteside --Tumor-microenvironment interactions: the seletcin-selectin ligand axis in tumor-endothelium cross talk /Isaac P. Witz --CD95L/FasL and trail in tumour surveillance and cancer therapy /Harald Wajant --Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer /Jessica Berout and Andrei Thomas-Tikhonenko --Cytokines as mediators and targets for cancer cachexia /Josep M. Argilés, Sílvia Busquets and Francisco J. López-Soriano --Targeting NF-[kappa]B in anticancer adjunctive chemotherapy /Burkhard Haefner.
  • Lip cancer 2014, Springer
    The lip is the most common site of malignancy in the head and neck region. Although high cure rates can be achieved by early treatment, a significant percentage of lip cancers demonstrate aggressive behaviour, posing management difficulties. Given the aesthetic and functional significance of the lip, reconstruction post surgery is also extremely important, yet this, too, can be challenging. This textbook is intended as a comprehensive reference that will provide easy-to-follow and well-organized guidance on the management of lip cancer, from diagnosis to treatment and reconstruction. After discussion of anatomy and premalignant conditions, detailed attention is paid to squamous cell carcinoma of the lip. Surgical management is explained, and the roles of radiation therapy and chemotherapy, discussed. Reconstruction techniques following ablative surgery are then described in depth, with reference to defect size and complexity. In addition, the potential complications of treatment and reconstruction are presented, with advice on their management. The closing chapter considers other malignant lesions of the lip. The informative text is complemented by high-quality illustrations and clinical and radiographic material. The contributors all have extensive experience and in-depth knowledge of the topics they address.
  • Structure and synthesis of lipid A / Shoichi Kusumoto, Masahito Hashimoto and Kazuyoshi Kawahara -- Conformation and supramolecular structure of lipid A / Klaus Brandenburg and Ulrich Seydel -- Interactions between lipid A and serum proteins / Jèorg Andrèa ... [et al.] -- The lipid A receptor / Kiyoshi Takeda -- Lipid A receptor TLR4-mediated signaling pathways / Masahiro Yamamoto and Shizuo Akira -- Lipid A-induced responses in vivo / Néjia Sassi ... [et al.] -- Lipid A-mediated tolerance and cancer therapy / Cheryl E. Rockwell, David C. Morrison and Nilofer Qureshi -- Lipid A in cancer therapies : preclinical results / Daniele Reisser and Jean-François Jeannin -- Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines : clinical results / Christopher W. Cluff -- Antitumoral effects of lipids A : clinical studies / Marc Bardou and Danièle Reisser.
  • Liver cancer 2009, Springer
  • Liver metastases 2009, Springer
  • Liver metastasis 2011, Springer
    Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
  • OBJECTIVES: We prepared this report on the comparative effectiveness and harms of lung-directed nonsurgical therapies for non-small-cell lung cancer (NSCLC) in three distinct patient populations: (1) patients with stage I NSCLC who are not surgical candidates (Key Question 1), (2) patients with stage I NSCLC who are deemed operable but decline surgery (Key Question 2), and (3) patients with endoluminal NSCLC causing obstruction (Key Question 3). For stage I NSCLC, the local nonsurgical interventions could include conformal radiotherapy modalities and radiofrequency ablation (RFA). For patients with airway obstruction due to an endoluminal NSCLC, local nonsurgical interventions could include those for the stage I setting, as well as conventional wide-field radiotherapy, brachytherapy, laser and mechanical debridement, endoluminal stents, cryoablation, and photodynamic therapy. Surgical resection of any type is not considered as a comparator for any of the Key Questions. DATA SOURCES: MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry were searched from January 1, 1995, to July 25, 2012. A search of the gray literature included databases with regulatory information, clinical trial registries, abstracts and conference papers, and information from manufacturers. REVIEW METHODS: We sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverse events, and quality of life among our populations of interest. Data were abstracted for each Key Question by a team of reviewers, with independent data verification. Study quality and the risk of bias of randomized controlled trials (RCTs) were assessed using the United States Preventive Services Task Force criteria. The quality and risk of bias of single-arm studies were assessed using the Carey and Boden criteria. The strength of the body of evidence was assessed according to the Agency for Healthcare Research and Quality Methods Guide. RESULTS: In our searches, we identified 4,648 unique titles and screened 1,178 in full text. Of the latter, 55 met the inclusion criteria. Thirty-five studies were relevant to Key Question 1, considering medically inoperable patients with stage I NSCLC; 6 were relevant to Key Question 2, considering medically operable patients with stage I NSCLC who decline surgery; and 17 were relevant to Key Question 3, considering patients with inoperable endoluminal NSCLC causing symptoms of obstruction. Three studies addressed both Key Questions 1 and 2. All studies relevant to Key Questions 1 and 2 were single-arm design, prospective (n=15), retrospective (n=21), or not specified (n=2). Among 17 papers included for Key Question 3, 5 were RCTs, 1 was a nonrandomized comparative study, and 11 were single-arm studies. Because comparative study evidence on RFA and debridement and stenting was unavailable for Key Question 3, we included evidence from two single-arm studies involving stents and one on RFA. All RCTs were of poor quality. Only one comparison was available per study, with no two studies examining the same set of interventions. Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of life. CONCLUSIONS: Evidence on localized nonsurgical therapies for patients with stage I NSCLC who are not surgical candidates or who decline surgery consists only of single-arm studies, with no direct comparisons among interventions. The best evidence for NSCLC patients with endoluminal obstruction consists of poor-quality single RCTs for each comparison; we did not identify evidence that permitted us to draw conclusions based on indirect comparisons. Overall, evidence is insufficient to permit conclusions on the comparative effectiveness of local nonsurgical therapies for inoperable or operable patients with stage I NSCLC or inoperable NSCLC patients with endoluminal tumor causing pulmonary symptoms.
  • Lung cancer 2010, Springer
  • Lung cancer 2003, Springer Protocols
    v. 2 Springer Protocols
    v. 1. Molecular pathology methods and reviews -- v. 2. Diagnostic and therapeutic methods and reviews.
  • Lung cancer imaging 2013, Springer
    While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their.
  • Lung cancer metastasis 2009, Springer
    Lung Cancer: Overview / Shirish M. Gadgeel and Gregory P. Kalemkerian -- Hallmarks of Metastasis / M. Roshni Ray and David M. Jablons -- Tumor Stem Cells and Metastasis / Jaclyn Y. Hung -- Epithelial-Mesenchymal Transition as a Mechanism of Metastasis / Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni and Aristidis Moustakas -- Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis / Charles Kumar Thodeti and Kaustabh Ghosh -- Immunologic Mechanisms in Lung Carcinogenesis and Metastasis / Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma and Tonya Walser, et al. -- Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis / Douglas A. Arenberg -- Chemokines in Lung Cancer Metastasis / Borna Mehrad, Ellen C. Keeley and Robert M. Strieter -- Molecular Control of Lymphatic Metastasis in Lung Cancer / Mark M. Fuster and Judith A. Varner -- Carcinoma-Associated Fibroblasts in Lung Cancer / Roya Navab, Bizhan Bandarchi and Ming-Sound Tsao -- The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer / Zvi G. Fridlender, M. Cecilia Crisanti and Steven M. Albelda -- Experimental Animal Models for Studying Lung Cancer / Jiang Liu and Michael R. Johnston -- Molecular Imaging in Lung Cancer Metastases / Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross and Alnawaz Rehemtulla -- Biomarker Discovery for Metastatic Disease / Gilbert S. Omenn and James D. Cavalcoli -- Current Clinical Management of Metastatic Lung Cancer / Bryan J. Schneider and Suresh S. Ramalingam -- Site-Directed Therapy for Lung Cancer Metastases / Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens and Malini Venkatram, et al. -- Systems Approach for Understanding Metastasis / Peter J. Woolf, Angel Alvarez and Venkateshwar G. Keshamouni.
  • Etiology and epidemiology -- Lung cancer biology -- Screening/early detection/prevention -- Pathology and molecular classification -- Clinical presentation, diagnosis, staging, and prognosis -- Surgery -- Radiation therapy -- Chemotherapy -- Multimodality therapy of NSCLC -- Treatment of small cell lung cancer -- Novel therapeutic strategies -- Palliation and special considerations -- Other thoracic tumors.
  • "Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology, namely, needle biopsy and bronchoscopy, fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation, Nodule segmentation, Vessels segmentation, Airways segmentation, Lung registration, Detection of lung nodules, Diagnosis of detected lung nodules, Shape and appearance analysis of lung nodules. Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging"--Provided by publisher.
  • Lymphoma 2013, Springer
    Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.
  • Lymphoma 2005, Springer Protocols
  • 1. Noninvasive Breast Cancer /Robert H. I. Andtbacka ... [et al.] --2. Invasive Breast Cancer /Jonathan S. Zager ... [et al.] --3. Melanoma /Timothy M. Pawlik and Jeffrey E. Gershenwald --4. Nonmelanoma Skin Cancer /Nestor F. Esnaola and Keith M. Heaton --5. Soft Tissue and Bone Sarcoma /Keith A. Delman and Janice N. Cormier --6. Cancer in the Head and Neck /Kenneth A. Newkirk and F. Christopher Holsinger --7. Thoracic Malignancies /Shanda H. Blackmon and Ara A. Vaporciyan --8. Esophageal Carcinoma /Alexander A. Parikh, Ara A. Vaporciyan, and Wayne L. Hofstetter --9. Gastric Cancer /Waddah B. Al-Refaie and Paul F. Mansfield --10. Small-Bowel Malignancies and Carcinoid Tumors /Keith D. Amos and Rosa F. Hwang --11. Cancer of the Colon, Rectum, and Anus /George J. Chang and Barry W. Feig --12. Hepatobiliary Cancers /Eugene A. Choi, Steven E. Rodgers, Syed A. Ahmad, and Eddie K. Abdalla --13. Pancreatic Adenocarcinoma /Rosa F. Hwang ... [et al.] --14. Pancreatic Endocrine Tumors and Multiple Endocrine Neoplasia /Jeffrey T. Lenert ... [et al.] --15. Adrenal Tumors /Ricardo J. Gonzalez and Jeffrey E. Lee --16. Carcinoma of the Thyroid and Parathyroid Glands /Keith D. Amos, Mouhammed A. Habra, and Nancy D. Perrier --17. Hematologic Malignancies and Splenic Tumors /Wayne A. I. Frederick ... [et al.] --18. Cancer of Unknown Primary Site /Gauri R. Varadhachary --19. Genitourinary Cancer /Christopher G. Wood and Colin P.N. Dinney --20. Gynecologic Cancers /Brian M. Slomovitz, Pamela T. Soliman, Judith K. Wolf --21. Oncologic Emergencies /Jeffrey D. Wayne and Richard J. Bold --22. Biologic Cancer Therapy /Daniel Albo, Thomas N. Wang, and George P. Tuszynski --23. Pharmacotherapy of Cancer /Judy L. Chase and Chad M. Barnett --24. Reconstructive Surgery in the Cancer Patient /Jules A. Feledy, Jr. Matthew M. Hanasono, and Geoffrey L. Robb --Index.
  • Malignant effusions 2012, Springer
    Morphological and Functional Characteristics of Serous Cavities /Olga V. Lebedinskaya, Irina Zh Shubina, Natalia Yu Anisimova, Alexey N. Kopylov and Mikhail V. Kiselevsky --Pathogenesis of Malignant Effusions /Irina O. Chikileva, Natalia Yu Anisimova, Irina Zh Shubina and Mikhail V. Kiselevsky --Diagnosis and Treatment of Malignant Pleural Effusion /Sergi Call, David Sánchez and Ramón Rami-Porta --Malignant Ascites: Diagnosis and Treatment /Fausto Petrelli and Sandro Barni --Malignant Pericardial Disease /Caroline Chiles and Girish Shroff --Adoptive Immunotherapy of Malignant Effusions /Irina Zh Shubina, Konstantin S. Titov, Irina O. Chikileva, Lev V. Demidov and Mikhail V. Kiselevsky --Hyperthermia and Intracavitary Chemotherapy in Prevention and Treatment of Malignant Effusions /Gianfranco Baronzio, Giammaria Fiorentini, Marco Ballerini, Valter Cassuti and Giorgio Forzenigo, et al.
  • Malignant mesothelioma 2005, Springer
  • Malignant mesothelioma 2011, Springer
  • Gastroesophageal cancers : providing an update / Jaffer A. Ajani -- Epidemiology and etiology of gastric cancer / Amitesh Roy, David Cunningham & Ian Chau -- Surgery of esophagogastric cancer : standards and challenges / Markus Moehler, Anne Palmqvist, Hauke Lang, Hans-Joachim Meyer & Ines Gockel -- Chemotherapy / Vincenzo Catalano & Francesco Graziano -- Targeted therapies / David H. Ilson & Elizabeth C. Smyth -- Guidelines for managing gastric cancer / Vikas Ghai & Yixing Jiang.
  • 1. Background and Epidemiology -- Basic Science of Breast Cancer in Older Patients / Irmgard Irminger-Finger -- Tumor Biology and Pathology / Virginie Durbecq and Denis Larsimont Clinical Epidemiology and the Impact of Co-Morbidity on Survival / Adri C. Voogd, Marieke J. Louwman and Jan Willem W. Coebergh -- 2. Special Considerations in the Management of Older Women -- Comprehensive Geriatric Assessment / Margot A. Gosney -- A Practical Mini-Guide to Comprehensive Geriatric Assessment / Siri Rostoft Kristjansson -- Impact of the Physiological Effects of Aging on the Pharmacokinetics and Pharmacodynamics of Systemic Breast Cancer Treatment / Paul Hamberg, Maja J. A. de Jonge and Caroline M. Seynaeve -- Impact of Hormone Replacement Therapy on Breast Cancer / Toral Gathani and Valerie Beral -- Experiences of a Multidisciplinary Elderly Breast Cancer Clinic: Using the Right Specialists, in the Same Place, with Time / Anne Stotter, Mohammad Tahir, Robert S. Pretorius and Thompson Robinson -- 3. Therapeutics -- Mammographic Breast Screening in Elderly Women / Lynda Wyld -- Primary Endocrine Therapy for the Treatment of Early Breast Cancer in Older Women / Lynda Wyld and Daniel Hind -- Peroperative Radiotherapy / Roberto Orecchia, Giovanni Battista Ivaldi and Maria Cristina Leonardi -- General and Local Anesthetics / Bernadette Th. Veering -- The Surgical Management of Breast Cancer in Elderly Women / Malcolm W. R. Reed, Lynda Wyld and Riccardo A. Audisio -- Breast Reconstruction / Marcus J. D. Wagstaff, Malcolm W. R. Reed and Christopher M. Caddy -- Adjuvant Endocrine Therapy / Laura Biganzoli -- Adjuvant Chemotherapy / Sumanta Kumar Pal, Nilesh Vora and Arti Hurria -- Adjuvant Radiotherapy / Pierre G. M. Scalliet -- Prevention and Treatment of Skeletal Complications / Matthew C. Winter, Helen L. Neville-Webbe and Robert E. Coleman -- Medical Management of Advanced Disease / Hans P. M. W. Wildiers -- The Use of Chemotherapy in Elderly Cancer Patients: Dose Adjusting, Drug Interactions, and Polypharmacy / Lazzaro Repetto and Claudia Di Bartolomeo -- 4. Psychosocial Considerations -- Delayed Presentation of Breast Cancer in Older Women / Lindsay J. L. Forbes and Amanda J. Ramirez -- Patient Decision Making / Martine Extermann -- Culture, Ethnicity, and Race: Persistent Disparities in Older Women with Breast Cancer / Antonella Surbone and Marjorie Kagawa-Singer -- Supportive, Palliative and End-of-Life Care for Older Breast Cancer Patients / Elaine Cachia, Ruth Broadhurst and Sam H. Ahmedzai.
  • Anatomy and Physiology of the Breast -- Congenital and Developmental Abnormalities of the Breast -- Nipple Discharge -- Mastalgia -- Management of Common Lactation and Breastfeeding Problems -- Evaluation of a Breast Mass -- Breast Cancer Epidemiology -- Breast Cancer Screening -- Breast Imaging -- Premalignant and Malignant Breast Pathology -- Lobular Carcinoma in Situ -- Ductal Carcinoma in Situ -- Surgical Considerations in the Management of Primary Invasive Breast Cancer -- Sentinel Node Concept -- Breast Reconstructive Surgery -- The Role of Radiotherapy in Breast Cancer Management -- Adjuvant Systemic Therapy for Breast Cancer: An Overview -- Endocrine Therapy -- Chemotherapeutic Agents -- HER2-Targeted Therapy -- Inflammatory and Locally Advanced Breast Cancer -- Preoperative (Neoadjuvant) Systemic Therapy -- Metastatic Breast Cancer -- Hormone Replacement Therapy: A Critical Review -- Breast Diseases in Males -- Breast Cancer in the Elderly -- Breast Cancer in Younger Women -- Psychological Support for the Breast Cancer Patient -- Management of the Patient with a Genetic Predisposition for Breast Cancer -- Chemoprevention of Breast Cancer -- Design, Implementation, and Interpretation of Clinical Trials -- Structure of Breast Care Center -- Medicolegal Pitfalls in Breast Cancer Diagnosis and Management.
  • Management of cancer in older people v. 1-, 2013-, Springer
    v. 2 Springer
    v. 3 Springer
    v. 4 Springer
  • Section 1. Screening/prevention -- section 2. Diagnosis/assessment -- section 3. Treatment -- section 4. Supportive care -- section 5. Rehabilitation/survivorship -- section 6. Special issues.
  • The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Management of Colorectal Cancers in Older People focuses on treatment strategies of colorectal cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older colorectal cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research. The third volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical and radiation oncologists, gerontologists, proctologists and other members of the multidisciplinary team involved in the care of elderly colorectal cancer patients.
  • The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Gynecological Cancers in Older Women focuses on treatment strategies of gynecological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older women, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older gynecological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.The second volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical oncologists, gerontologists, gynecologists and other members of the multidisciplinary team involved in the care of elderly gynecological cancer patients.
  • This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.
  • This book pursues a multidisciplinary approach, presenting chapters with updated information on various aspects of treatment for patients with neuroendocrine tumors. Authors have been selected from expert centers in Europe and the United States. The goal of this book is to comprehensively summarize recent data and provide inspiring ideas to optimize the care of patients with neuroendocrine tumors. Neuroendocrine tumors are fascinating multifaceted diseases that can primarily localize in many organs with various presentations. These tumors are rare but their increasing incidence renders likely that physicians caring for cancers may have either already faced or may be certainly exposed to diagnose and/or treat a patient with neuroendocrine tumors. Over the last years, novel therapeutic options have emerged for neuroendocrine tumors, profoundly challenging practices that had previously been the standards for decades. These include - but are not limited to - somatostatin analogues, targeted therapies such as tyrosine kinase and mTOR inhibitors, antiangiogenic compounds, but also peptide-receptor targeted therapy or radioembolization. This changing field has generated novel treatment algorithms to guide medical decisions. To better understand and handle the multidisciplinary approaches that are required for optimizing the care of neuroendocrine tumor patients, physicians are now looking for references from experts and comprehensive reviews summarizing current knowledge on treatments for patients with neuroendocrine tumors.
  • Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches, and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology, and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.
  • Epidemiology of Prostate Cancer in Europe /Ruben G. Cremers and Lambertus A. Kiemeney --Chemoprevention of Prostate Cancer /Bertrand Tombal --Individual and Mass Screening /Chris H. Bangma, Pim J. van Leeuwen and Monique J. Roobol --Anatomo-Pathology /Theodorus H. Van der Kwast --Biomarkers for Prostate Cancer /Gisele H. J. M. Leyten, Peter F. A. Mulders and Jack A. Schalken --Diagnosis, Clinical Work Up, TNM Classification, Markers /Jean-Luc Descotes and Anne-Sophie Gauchez --Active Surveillance for Favorable Risk Prostate Cancer: Background, Patient Selection, Triggers for Intervention, and Outcomes /Laurence Klotz --Open Radical Prostatectomy /Hein van Poppel and Steven Joniau --Robot-Assisted Radical Prostatectomy /Stefan Carlsson and Nils Peter Wiklund --Permanent Prostate Brachytherapy /Jan J. Battermann --High-Dose-Rate Brachytherapy: Indications, Technique, and Results /Alberto Bossi, Rodolfe Verstraet, Lucie Calmels and Pierre Blanchard.Intensity Modulated Radiotherapy for Prostate Cancer /Olivier Chapet, Corina Udrescu and Ciprian Enachescu --Combination of Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced and Localized Prostate Cancer /Michel Bolla and Camille Verry --Postoperative Irradiation: Immediate or Early Delayed? /Dirk Bottke and Thomas Wiegel --High-Intensity Focused Ultrasound (HIFU) for Prostate Cancer /Albert Gelet, Sebastien Crouzet, Olivier Rouviere and Jean-Yves Chapelon --Cryotherapy /Matvey Tsivian and Thomas J. Polascik --Follow-up After Radical Treatments and Relapse /Nicolas Mottet --First-Line Hormonal Manipulation of Prostate Cancer /Suresh Venugopal and John Anderson --Resistance to Chemical Castration: Second-Line Hormonal Treatment /Yohann Loriot, Christophe Massard and Karim Fizazi --Targeted Therapies and Vaccination /Guru Sonpavde and Cora N. Sternberg --How to Interpret Results? /Laurence Collette --Management of Prostate Cancer: EAU Guidelines on Screening, Diagnosis and Treatment /Axel Heidenreich --Better Patients' Perspective /Louis J. Denis.
  • Epidemiology and risk factors / Ranko Miocinovic -- Twenty years and counting : is PSA still useful in 2010? / Haluk Ozen and Sertac Yazici -- Prostate cancer screening : a review of the evidence with clinical practice implications / Timothy J. Wilt -- Beyond PSA : promising new markers for prostate cancer / Leonard Marks -- Hereditary prostate cancer and genetic risk / Adam C. Reese, Graham Casey, and John S. Witte -- Prostate inflammation and prostate cancer / William G. Nelson ... [et al.] -- Molecular progression of prostate cancer : androgens and estrogens / Stephen A. Boorjian and Donald J. Tindall -- The role of obesity and diet in prostate cancer / Jean-Alfred Thomas II and Stephen J. Freedland -- Prostate cancer risk reduction by chemoprevention / Kenneth G. Nepple, Adam S. Kibel, and Gerald L. Andriole -- Current issues in pathologic evaluation / Sara M. Falzarano, Howard S. Levin, and Cristina Magi-Galluzzi -- Optimum prostate biopsy : techniques and strategies / Osama M. Zaytoun and J. Stephen Jones -- The utility of nomograms in routine clinical practice / Carvell T. Nguyen and Michael W. Kattan -- Active surveillance comes of age / Laurence Klotz -- Focal therapy : prostate hemiablation as the first historical treatment model for focal therapy of early stage prostate cancer / Vladimir Mouraviev and Thomas J. Polascik -- Contemporary external beam radiotherapy / Rahul Tendulkar and Kevin Stephans -- Surgery, brachytherapy, or external beam radiation for low- and intermediate-risk disease? / Jay P. Ciezki and Eric A. Klein -- The role for radical prostatectomy in advanced prostate cancer / R. Jeffrey Karnes and Michael L. Blute -- Radiation therapy in the management of locally advanced prostate cancer / Joseph D. Mancias and Anthony L. Zietman -- Clinical implications of measuring quality-of-life in early stage prostate cancer / Peter Chang, Mehrdad Alemozaffar, and Martin G. Sanda -- Treatment modalities of post-prostatectomy incontinence : a historical perspective as well as current therapy options / Christina Ching and Drogo K. Montague -- Management of biochemical recurrence after localized treatment for prostate cancer / Stephen B. Williams and Toni K. Choueiri -- Management of newly diagnosed metastatic disease / C. Lance Cowey and Thomas E. Hutson -- Pitfalls of androgen deprivation therapy / Alicia K. Morgans and Matthew R. Smith -- Current management of castration-resistant prostate cancer (CRPC) / Jorge A. Garcia and Robert Dreicer -- Beta-emitting radiopharmaceuticals and bone metastasis / Oliver Sartor.
  • Section 1 CNS tumors -- Germinal tumours of the central nervous system in adult patients -- Atypical and malignant meningiomas -- Primary central nervous system lymphoma -- Treatment of Medulloblastoma in adults -- Cerebellar glioblastoma multiforme -- Chordoma and chondrosarcoma of the skull base -- Primary spinal epidural lymphoma -- Section 2 Heads and neck tumors -- Esthesioneuroblastoma -- Extranodal NK/T-cell lymphoma, nasal-type -- Uncomon tumours of the nasopharynx -- Rare malignant tumours of the larynx and hypopharynx -- Primary orbital lymphoma -- Primary MALT lymphoma of the salivary glands -- Section 3 Gastro-intestinal tumors -- Mucosal melanoma of the upper aero-digestive tract -- Gastrointestinal stromal tumours -- Small cell carcinomas of the gastrointestinal tract -- Small cell carcinomas of the gastrointestinal tract -- Anorectal Melanoma -- Uncommon Hepatobiliary Tumours -- Unusual pancreatic tumours -- Section 4 Genitourinary -- Rare tumours of the renal pelvis and ureter -- Rare tumours of the urethra -- Uncommon bladder cancers -- Neuroendocrine small cell carcinoma of the prostate: A brief review of pathology, clinical characteristics and treatment guidelines -- Uncommon tumours of the testis -- Primary Testicular lymphoma -- Human chorionic gonadotropin-producing seminoma -- Section 5 Gynecological -- Rare ovarian cancers -- Extraovarian primary peritoneal carcinoma -- Uterine papillary serous carcinoma -- Uterine sarcomas and rare endometrial carcinomas -- Uterine sarcomas and rare endometrial carcinomas -- Rare tumours of the uterine cervix -- Tumours of the vagina and tumours of the vulva -- Section 6 Breast -- Invasive breast cancer and ductal carcinoma in situ in young women -- Tubular carcinoma of the breast -- Adenoid cystic carcinoma of the breast -- Primary squamous cell carcinoma of the breast -- Primary breast lymphoma -- Phyllodes tumours of the breast -- Primary breast sarcomas -- Angiosarcoma of the breast -- Male breast cancer -- Section 7 Lung and intrathoracic malignancies -- Primary uncommon tumours of the lung: lymphomas, sarcomas and melanomas -- Thymoma and thymic carcinoma -- Large cell neuroendocrine carcinoma of the lung -- Neuroendocrine tumours of the lung -- Pleural mesothelioma -- Bronchioloalveolar carcinoma and adenocarcinoma with bronchioloalveolar carcinoma features: a clinico-pathological spectrum -- Primary adenoid cystic carcinoma of the trachea and bronchus -- Tracheal cancers -- Section 8 Malignancies of the skin -- Unusual cutaneous malignancies: cutaneous adnexal tumours -- Kaposi's sarcoma -- Dermatofibrosarcoma protuberans (DFSP) -- Merkel cell carcinoma: A challenge in cancer management -- Langerhans cell histiocytosis (LCH) -- Section 9 Other malignancies -- Primary bone lymphoma (osteolymphoma) -- Erdheim-Chester disease -- Solitary plasmacytoma -- Neuroendocrine tumours.
  • Management of Soft Tissue Sarcoma addresses the diagnosis and best current management of adult soft tissue sarcomas. Edited by world renonwed experts, this book dileneates and discusses each different sarcoma subtype individually --source other than Library of Congress.
  • Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies.
  • The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Urological Cancers in Older People focuses on treatment strategies of urological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older urological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.This first volume in the Management of Cancer in Older People series will be of interest to all surgical oncologists, medical oncologists, gerontologists, urologists and other members of the multidisciplinary team involved in the care of elderly urological cancer patients.
  • Managing Cancer Breakthrough Pain is a comprehensive review of cancer breakthrough pain (cBTP) and rapid-onset opioids (ROO), the only treatment approved for cBTP episodes. The book was originally commissioned due to the current rapid growth of the ROO market and the epidemic of ROO abuse. This book will review the historical background and definitions of cBTP and ROOs, assessment methods to determine types of cBTP, US- and EU-approved ROOs, case studies (which will provide practical applications of ROO treatment options), ROO abuse and screening methods, and the FDA-mandated TIRF REMS Access program (Transmucosal Immediate Release Fentanyl Risk Evaluation and Mitigation Strategies Access program). Busy healthcare professionals who have a basic understanding of cancer pain but want to learn more about cBTP and ROOs will benefit from this concise guide that will help them quickly understand the complexities of cBTP episodes and ROOs.
  • Managing skin cancer 2010, Springer
    Diagnosis of Skin Cancer -- Histopathology of Skin Cancer -- Basal Cell Carcinoma -- Squamous Cell Carcinoma In Situ -- Invasive Squamous Cell Carcinoma of the Skin -- Cutaneous Malignant Melanoma -- Merkel Cell Carcinoma -- Cutaneous Lymphomas -- Kaposi Sarcoma -- Other Skin Cancers. Fibrohistiocytic Skin Cancers and Extramammary Paget's Disease -- Skin Cancer Under Special Circumstances -- Skin Cancer Prevention.
  • Chapter 1. Classification and Diagnosis of Anemia in Children -- Chapter 2. Anemia During the Neonatal Period -- Chapter 3. Iron-Deficiency Anemia -- Chapter 4. Megaloblastic Anemia -- Chapter 5. Hematologic Manifestations of Systemic Illness -- Chapter 6. Bone Marrow Failure -- Chapter 7. Red Cell Membrane and Enzyme Defects -- Chapter 8. Hemoglobinopathies -- Chapter 9. Extracorpuscular Hemolytic Anemia -- Chapter 10. Polycythemia -- Chapter 11. Disorders of White Blood Cells -- Chapter 12. Disorders of Platelets -- Chapter 13. Hemostatic Disorders -- Chapter 14. Thrombotic Disorders -- Chapter 15. Lymphadenopathy and Splenomegaly -- Chapter 16. Lymphoproliferative Disorders, Myelodysplastic Syndromes and Myeloproliferative Disorders -- Chapter 17. Leukemias -- Chapter 18. Histiocytosis Syndromes -- Chapter 19. Hodgkin Lymphoma -- Chapter 20. Non-Hodgkin Lymphoma -- Chapter 21. Central Nervous System Malignancies -- Chapter 22. Neuroblastoma -- Chapter 23. Renal Tumors -- Chapter 24. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas -- Chapter 25. Malignant Bone Tumors -- Chapter 26. Retinoblastoma -- Chapter 27. Germ Cell Tumors -- Chapter 28. Hepatic Tumors -- Chapter 29. Hematopoietic Stem Cell Transplantation -- Chapter 30. Management of Oncologic Emergencies -- Chapter 31. Supportive Care of Patients with Cancer -- Chapter 32. Evaluation, Investigations and Management of Late Effects of Childhood Cancer -- Chapter 33. Psychosocial Aspects of Cancer for Children and their Families.
  • Cancer symptoms and side effects of treatment -- Cancer pain -- Cancer-related fatigue -- Palliative care: end-of-life symptoms -- Supportive care in elderly cancer patients -- Supportive care in pediatric oncology -- Quality-of-life assessment: the challenge of incorporating quality-of-life and patient-reported outcomes into investigative trials and clinical practice -- Cardiac toxicities of cancer therapies: challenges for patients and survivors of cancer -- Malignant pericardial effusion and cardiac tamponade (cardiac and pericardial symptoms) -- The vena cava syndrome -- Pulmonary toxicity of therapy -- Management of respiratory symptoms in people with cancer -- Endocrine and metabolic symptoms of cancer and its treatment -- Sexual problems in patients with cancer -- Sterility, infertility, and teratogenicity -- Menopause symptoms -- Preserving cardiac health in the breast cancer patient treated with anthracyclines -- Thrombosis and bleeding in cancer patients -- Lymphedema care -- Infections and cancer --Cancer cachexia and anorexia -- Xerostomia and dental problems in the head and neck radiation patient -- Dysphagia, reflux, and hiccups -- Nausea and vomiting -- Mucositis (oral and gastrointestinal) -- Diarrhea, constipation, and obstruction in cancer management -- Ascites -- Hepatotoxicity and hepatic dysfunction -- Urological symptoms and side effects of treatment -- Gynecological symptoms -- Central nervous system symptoms: headache, seizures, encephalopathy, and memory impairment -- Neuromuscular disease and spinal cord compression -- Eye symptoms and toxicities of systemic chemotherapy -- Extravasation -- Dermatologic toxicities -- Chemotherapy-induced alopecia: overview and methodology for characterizing hair changes and regrowth -- Rehabilitation in cancer -- Oral health and survivorship: late effects of cancer and cancer therapy -- Survivorship: psychosocial, physical issues, and insomnia -- Spiritual issues in supportive cancer care.
  • Mast cells and tumours 2011, Springer
  • Part I. Leukemia -- Chapter 1. Acute Lymphoblastic Leukemia -- Chapter 2. Adult Acute Myeloid Leukemia -- Chapter 3. Chronic Lymphocytic Leukemia and Associated Disorders -- Chapter 4. Chronic Myeloid Leukemia -- Chapter 5. Myelodysplastic Syndromes: The MD Anderson Cancer Center Approach -- Chapter 6. Philadelphia Chromosome-Negative Myeloproliferative Neoplasms -- Part II. Lymphoma and Myeloma -- Chapter 7. The Indolent Lymphomas -- Chapter 8. Aggressive and Highly Aggressive B-Cell Lymphomas -- Chapter 9. T-Cell Lymphomas -- Chapter 10. Hodgkin Lymphoma -- Chapter 11. Multiple Myeloma and Other Plasma Cell Dyscrasias -- Part III. Stem Cell Transplantation -- Chapter 12. Allogeneic Transplantation -- Chapter 13. Autologous Stem Cell Transplantation -- Part IV. Lung Cancer -- Chapter 14. Small Cell Carcinoma of the Lungs -- Chapter 15. Non-Small Cell Lung Cancer -- Part V. Head and Neck Cancer -- Chapter 16. Head and Neck Cancer -- Part VI. Gastrointestinal Carcinomas -- Chapter 17. Gastric and Esophageal Cancer -- Chapter 18. Pancreatic Cancer -- Chapter 19. Hepatobiliary Malignancies -- Chapter 20. Small Bowel Cancer and Appendiceal Tumors -- Chapter 21. Colorectal Cancer -- Chapter 22. Anal Cancer -- Chapter 23. Neuroendocrine Tumors -- Part VII. Breast Cancer -- Chapter 24. Early-Stage and Locally Advanced Breast Cancer -- Chapter 25. Metastatic Breast Cancer --Chapter 26. Inflammatory Breast Cancer -- Chapter 27. Special Situations in Breast Cancer -- Part VIII. Gynecologic Malignancies -- Chapter 28. Ovarian Cancer -- Chapter 29. Tumors of the Uterine Corpus -- Chapter 30. Tumors of the Uterine Cervix -- Chapter 31. Gestational Trophoblastic Tumors -- Part IX. Genitourinary Carcinoma -- Chapter 32. Renal Cell Carcinoma -- Chapter 33. Bladder Cancer -- Chapter 34. Prostate Cancer -- Chapter 35. Penile Cancer -- Chapter 36. Germ Cell Tumors -- Part X. Miscellaneous Tumors -- Chapter 37. Tumors of the Central Nervous System -- Chapter 38. Endocrine Malignancies -- Chapter 39. Malignant Melanoma -- Chapter 40. Soft Tissue and Bone Sarcomas -- Chapter 41. The AIDS-Related Cancers -- Chapter 42. Carcinoma of Unknown Primary -- Part XI. Supportive Care -- Chapter 43. Infection in the Neutropenic Patient -- Chapter 44. Fungal and Viral Infections in Cancer Patients -- Chapter 45. Endocrine and Metabolic Complications of Cancer Therapy -- Chapter 46. Oncologic Emergencies -- Part XII. Palliative Care and Symptom Management -- Chapter 47. Defining Palliative Care in Oncology -- Chapter 48. Pain Management and Symptom Control -- Part XIII. Long-Term Survival -- Chapter 49. Pediatric Long-Term Follow-Up -- Chapter 50. Adult Long-Term Follow-Up -- Chapter 51. Rehabilitation.
  • "The current edition of The Handbook provides an overview of current care of patients with cancer diagnoses commonly evaluated and treated by surgical oncologists, and in doing so continues to align such care with the underlying philosophy of the Department of Surgical Oncology at M.D. Anderson: multidisciplinary, cooperative care is the ideal way to manage patients with cancer. Such care begins with an understanding of the underlying tumor biology and natural history of the disease and includes technical excellence in the delivery of indicated surgical treatment. It also demands integration of essential information from the available literature on currently preferred treatment modalities, and emphasizes appropriate inclusion of adjunctive specialty care, including medical oncology, radiation oncology, interventional radiology, palliative care, pain management, physical therapy, nutritional support, social services and nursing"--Provided by publisher.
  • 1. Cytokines and Stressors: Implications for Cancer Immunotherapy -- 2. The Role of Oncogene Activation in Tumor Progression -- 3. Carcinogenic Effects of Ionising Radiation -- 4. Chemical Carcinogenesis Role of Chloroform Further Studies -- 5. Use of Organ Explant and Cell Culture in Cancer Research -- 6. Chromosomal Abnormalities in Selected Hematopoietic Malignancies Detected by Conventional and Molecular Cytogenetics: Diagnostic and Prognostic Significance -- 7. Mechanisms of Cancer Growth and Progression in Lymphoma -- 8. Pediatric Cancer Mechanisms of Cancer Growth and Progression -- 9. Carcinogenetic Pathway of Malignant Melanoma -- 10. Ewing Sarcoma: Molecular Characterization and Potential Molecular Therapeutic Targets -- 11. Molecular Mechanisms of Central Nervous System Metastasis -- 12. Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma -- 13. Postmenopausal Hormone Replacement Therapy and Breast Cancer Clinicopathologic Associations and Molecular Mechanisms -- 14. Carcinogenesis of Lung Cancer -- 15. Genesis of Barretts Neoplasia: Current Concepts -- 16. Genesis of Pancreatic Ductal Neoplasia -- 17. Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms -- 18. Mechanisms of Carcinogenesis in Colorectal Cancer -- 19. Carcinogenetic Pathway of Superficial Low-Grade Urothelial Carcinoma -- 20. Carcinogenetic Pathway of Urothelial Carcinoma -- 21. Mechanisms of Carcinogenesis in Prostate Cancer -- 22. HPV in Cervical Carcinoma -- Index.
  • Melanoma development 2011, Springer
  • Merkel cell carcinoma 2013, Springer
    Part I: Basic Science and Epidemiology -- Basic Science of the Merkel Cell -- Epidemiology and Genetics (Including High Risk Patients, Polyomavirus, Prognostic Factors) -- Part II: Diagnosis -- Clinical Diagnosis -- Staging -- Histopathologic Diagnosis -- Part III: Therapy -- Local Excision (Primary, Recurrent Disease) -- Lymph Node Procedures of the Head and Neck -- Lymph Node Procedures of the Trunk and Extremities -- Radiation Therapy (Primary and Recurrent Disease) -- Chemotherapy (Primary and Recurrent Disease) -- Treatment Algorithm -- Part IV: Expert Opinions and Future Directions -- Case Study A: Multiply Recurrent Merkel Cell Carcinoma -- Case Study B: Radiation Monotherapy for Extensive Local and In-Transit Merkel Cell Carcinoma -- Case Study C: Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver -- Case Study D: Evaluation of Multiple Merkel Cell Carcinomas in a Single Patient -- Case Study E: Multidisciplinary Management of Merkel Cell Carcinoma -- Track and Attack: Emerging Prognostic and Therapeutic Approaches.
  • 1. The metastatic process: an overview -- 2. Physiopathology of colorectal metastasis -- 3. The genetics of colorectal cancer -- 4. Epigenetics of colorectal cancer -- 5. Cancer-initiating cells in colorectal cancer -- 6. Epithelial-mesenchymal transition in colorectal cancer -- 7. Cell adhesion molecules in colon cancer metastasis -- 8. Epithelial cell signalling in colorectal cancer metastasis -- 9. Angiogenesis and lymphangiogenesis in colon cancer metastasis -- 10. Role of the host inflammaory response in colon carcinoma initiation, progression, and liver metastasis -- 11. Molecular prognostic markers in colon cancer -- 12. The sentinel lymph node and staging of colorectal cancer -- 13. Treatment of colorectal cancer -- 14. Diagnosis and treatment of rectal cancer -- 15. Future directions -- Index.
  • Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • Manufacturing of microarrays -- Technological platforms for microarray gene expression profiling -- Principles of gene microarray data analysis -- Gaining weights ... and feeling good about it! -- Complementary techniques -- Microarrays for cancer diagnosis and classification -- Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy -- Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs -- SNP and mutation analysis -- Cancer development and progression -- Gene expression profiling in malignant lymphomas -- Tumor immunology.
  • MicroRNA and Cancer 2011, Springer Protocols
    MicroRNA Biogenesis and Cancer / Julia Winter, Sven Diederichs -- Computational Identification of miRNAs Involved in Cancer / Anastasis Oulas, Nestoras Karathanasis, Panayiota Poirazi -- The Principles of MiRNA-Masking Antisense Oligonucleotides Technology / Zhiguo Wang -- The Concept of Multiple-Target Anti-miRNA Antisense Oligonucleotide Technology / Zhiguo Wang -- Modulation of MicroRNAs for Potential Cancer Therapeutics / Wei Wu -- Detection of MicroRNAs in Cultured Cells and Paraffin-Embedded Tissue Specimens by In Situ Hybridization / Ashim Gupta, Yin-Yuan Mo -- MicroRNA Northern Blotting, Precursor Cloning, and Ago2-Improved RNA Interference / Julia Winter, Sven Diederichs -- miRNA Profiling on High-Throughput OpenArray System / Elena V. Grigorenko, Elen Ortenberg, James Hurley, Andrew Bond, Kevin Munnelly -- Silicon Nanowire Biosensor for Ultrasensitive and Label-Free Direct Detection of miRNAs / Guo-Jun Zhang -- High-Throughput and Reliable Protocols for Animal MicroRNA Library Cloning / Caide Xiao -- MicroRNA Regulation of Growth Factor Receptor Signaling in Human Cancer Cells / Keith M. Giles, Andrew Barker, Priscilla M. Zhang, Michael R. Epis, Peter J. Leedman -- Epigenetic Regulation of MicroRNA Expression in Cancer / Hani Choudhry, James W. Catto -- In Vitro Functional Study of miR-126 in Leukemia / Zejuan Li, Jianjun Chen -- Prediction of the Biological Effect of Polymorphisms Within MicroRNA Binding Sites / Debora Landi, Roberto Barale, Federica Gemignani, Stefano Landi -- The Guideline of the Design and Validation of MiRNA Mimics / Zhiguo Wang -- Analysis of Targets and Functions Coregulated by MicroRNAs / Shu-Jen Chen, Hua-Chien Chen -- Utilization of SSCprofiler to Predict a New miRNA Gene / Anastasis Oulas, Panayiota Poirazi -- MicroRNA Profiling Using Fluorescence-Labeled Beads: Data Acquisition and Processing / Thomas Streichert, Benjamin Otto, Ulrich Lehmann.
  • MicroRNA in cancer 2013, Springer
    The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
  • Measurement and interpretation of microRNA expression profiles / Bo Curry and Robert Ach -- MicroRNA expression analysis by LNA enhanced microarrays / Rolf Sokilde ... [et al.] -- Analysis and QC for real-time OPCR arrays of human microRNAs / Dirk P. Ditmer ... [et al.] -- Massively parallel microRNA profiling in the haematologic malignancies / Ryan D. Morin ... [et al.] -- Who dunit? microRNAs involved in prostate cancer / Chang Hee Kim -- Intronic microRNA : creation, evolution and regulation / Sailen Barik and Titus Barik -- miRome architechture and genomic instability / Konrad Huppi ... [et al.] -- Interconnection of microRNA and transcription factor-mediated regulatory networks / Yiming Zhou -- Analysis of microRNA profiling data with systems biology tools / Yuriy Gusev ... [et al.] -- Mathematical and computational modeling of post-transriptional gene regulation by microRNAs / Raya Khanin and Desmond J. Higham.
  • Part 1.Introduction --Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer: Open Questions for Research /Michail Ignatiadis, Christos Sotiriou and Klaus Pantel --Part 2.Minimal residual disease and breast cancer metastasis --Self-Seeding in Cancer /Elizabeth Comen and Larry Norton --Microenvironments Dictating Tumor Cell Dormancy /Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso --Part 3.Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization --Immunomagnetic Separation Technologies /Astrid E. L. M. Hoeppener, Joost F. Swennenhuis and Leon W. M. M. Terstappen --Microfluidic Technologies /Ali Asgar. S. Bhagat and Chwee Teck Lim --EPISPOT Assay: Detection of Viable DTCs/CTCs in Solid Tumor Patients /Catherine Alix-Panabières --Advances in Optical Technologies for Rare Cell Detection and Characterization /Lou Dietz and Richard Bruce --Size-Based Enrichment Technologies for CTC Detection and Characterization /Anthony Williams, Marija Balic, Ram Datar and Richard Cote --Emerging Technologies for CTC Detection Based on Depletion of Normal Cells /Maryam Lustberg, Kris R. Jatana, Maciej Zborowski and Jeffrey J. Chalmers --Molecular Assays for the Detection and Characterization of CTCs /Evi S. Lianidou and Athina Markou --Multiplex Molecular Analysis of CTCs /Anieta M. Sieuwerts and Stefanie S. Jeffrey.Part 4.Other blood-based biomarkers /Circulating DNA and Next-Generation Sequencing --Susanna Cooke and Peter Campbell --Circulating MicroRNAs as Noninvasive Biomarkers in Breast Cancer /Maria Angelica Cortez, James William Welsh and George Adrian Calin --Circulating Endothelial Cells and Circulating Endothelial Progenitors /Patrizia Mancuso, Angelica Calleri and Francesco Bertolini --Part 5.Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in breast cancer clinical research and practice --DTCs in Breast Cancer: Clinical Research and Practice /W. Janni, Brigitte Rack, N. Kasprowicz, C. Scholz and P. Hepp --CTCs in Primary Breast Cancer (I) /Brigitte Rack, Ulrich Andergassen, Wolfgang Janni and Julia Neugebauer --CTCs in Primary Breast Cancer (II) /E. Saloustros and D. Mavroudis --CTCs in Metastatic Breast Cancer /Antonio Giordano and Massimo Cristofanilli --HER2-Positive DTCs/CTCs in Breast Cancer /Andreas D. Hartkopf, Malgorzata Banys and Tanja Fehm --DTCs/CTCs in Breast Cancer: Five Decades Later /Susan Alsamarai, Maysa M. Abu-Khalaf and Lyndsay N. Harris --Part 6.Drug and circulating tumor cell co-development --Challenges in Drug and Biomarker Co-Development /Sheila E. Taube and Tracy Lively --Challenges and Opportunities in the Use of CTCs for Companion Diagnostic Development /Elizabeth A. Punnoose and Mark R. Lackner.
  • As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.
  • Mitochondria and cancer 2009, Springer
  • Malignant tumors due to breast cancer and masses due to benign disease appear in mammograms with different shape characteristics: the former usually have rough, spiculated, or microlobulated contours, whereas the latter commonly have smooth, round, oval, or macrolobulated contours. Features that characterize shape roughness and complexity can assist in distinguishing between malignant tumors and benign masses. In spite of the established importance of shape factors in the analysis of breast tumors and masses, difficulties exist in obtaining accurate and artifact-free boundaries of the related regions from mammograms. Whereas manually drawn contours could contain artifacts related to hand tremor and are subject to intra-observer and inter-observer variations, automatically detected contours could contain noise and inaccuracies due to limitations or errors in the procedures for the detection and segmentation of the related regions. Modeling procedures are desired to eliminate the artifacts in a given contour, while preserving the important and significant details present in the contour.
  • This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens. The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.
  • Modern molecular biology 2010, Springer
    Genome-Scale Analysis of Data from High-Throughput Technologies / Sarah J. Wheelan -- Analysis of Inherited and Acquired Genetic Variation / Srinivasan Yegnasubramanian and William B. Isaacs -- Examining DNA-Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis / Esteban Ballestar and Manel Esteller -- Genome-Wide DNA Methylation Analysis in Cancer Research / Srinivasan Yegnasubramanian and William G. Nelson -- Use of Expression Microarrays in Cancer Research / Jun Luo and Yidong Chen -- Signal Sequencing for Gene Expression Profiling / Biaoyang Lin, Jeremy Wechsler and Leroy Hood -- Mass Spectrometry Based Proteomics in Cancer Research / Mohamad A. Abbani, Parag Mallick and Maryann S. Vogelsang -- Tissue Microarrays in Cancer Research / Toby C. Cornish and Angelo M. De Marzo.
  • An Introduction to Mohs Micrographic Surgery --Indications for Mohs Micrographic Surgery --Preoperative Evaluation --Mohs Micrographic Surgery Operative Room Setup --Anesthetic Considerations: Local Versus Regional --Cutaneous Anatomy in Mohs Micrographic Surgery --Mohs Surgery: Fixed Tissue Technique --Fresh Tissue Technique --Special Considerations for Mohs Micrographic Surgery in Organ Transplant Recipients --Mohs Micrographic Surgery in Ethnic Skin --Histopathology Laboratory Setup and Necessary Instrumentation --Tissue Transport and Initial Processing Cryostat Preparation of Slides --Histopathologic Interpretation of Mohs Slides --Tissue Specimen Documentation, Record Keeping, and Sample Storage --Immunostains --Basal Cell Carcinoma --Squamous Cell Carcinoma --Mohs Micrographic Surgery for the Treatment of Cutaneous Melanoma --Dermatofibrosarcoma Protuberans --Microcystic Adnexal Carcinoma --Atypical Fibroxanthoma --Extramammary Paget Disease --Leiomyosarcoma --Merkel Cell Carcinoma --Selected Sweat Gland Carcinomas --Sebaceous Carcinoma --Mohs Micrographic Surgery for the Eyelid --Mohs Surgery for Periungual and Subungual Skin Cancer --Genitalia --Deep Structures of the Head and Neck --Complications of Mohs Micrographic Surgery --Eyelid Reconstruction After Mohs Micrographic Surgery --Flaps --Skin Grafting --Side to Side Closure After Mohs Surgery --Prosthetic Rehabilitation --Combination Therapy for the Nonsurgical Treatment of Skin Cancers: Latest Research at Mount Sinai --Training and Regulation in Mohs Surgery --Establishing a Mohs Practice --International Perspective of Mohs Micrographic Surgery: South America --International Perspective of Mohs Micrographic Surgery: Europe --International Perspective of Mohs Micrographic Surgery: East Asia --International Perspective of Mohs Micrographic Surgery: Australia and New Zealand --Information for Patients and Safety Considerations --Ethical Issues Related to Mohs Skin Cancer Surgery --Medicolegal Issues Regarding Mohs Micrographic Surgery --Psychological Issues Regarding Mohs Micrographic Surgery.
  • Molecular approaches to controlling cancer 2005, Cold Spring Harb Lab Press
    Cancer genetics and genomes -- DNA damage response -- Cancer biology and stem cells -- Telomeres, senescence, and aging -- Animal models for cancer -- Gene expression and cancer -- Tumor responses to microenvironment -- Angiogenesis -- Discovering cancer targets -- Therapeutic approaches.
  • Part 1.Molecular Biology of Selected Hemato-oncologic Diseases --Molecular Biology of Acute Lymphoblastic Leukemia /Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich and Tomasz Szczepański --Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia /Agata A. Filip, Marta Libura, Sebastian Giebel and Olga Haus --Molecular Pathogenesis of Aggressive B-cell Lymphomas /Przemysław Juszczyński and Krzysztof Warzocha --Molecular Biology and Classification of Multiple Myeloma /Anna Dmoszyńska and Norbert Grząśko --Chronic Lymphocytic Leukemia /Anton W. Langerak and Yorick Sandberg --Molecular Biology of Chronic Myeloid Leukemia /Tomasz Sacha, Kajetana Foryciarz and Aleksander B. Skotnicki --Molecular Biology of Myelodysplastic Syndromes /Francesc Solé --Myeloproliferative Neoplasms /Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner and Aleksandra Leszczyńska --Part 2.Diagnostics and Monitoring of Therapy of Hemato-oncologic Deseases --Flow Cytometric Immunophenotyping as Diagnostic Tool of Hematopoietic Malignancies /Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena and Julia Almeida, et al. --Cytogenetics in Hematology /Olga Haus, Anna Poluha and Katarzyna Skonieczka --Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia /Tomasz Szczepański, Małgorzata Dawidowska and Katarzyna Derwich --Gene Expression Profiling in Hematologic Malignancies /Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak and Krzysztof Warzocha --Part 3.Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation --Allogeneic Transplantation of Hematopoietic Stem Cells /Jacek Wachowiak --Genetic Basis of Donor-Recipient Matching in Allogeneic Transplantation of Hematopoietic Stem Cells /Jacek Nowak and Jacek Wachowiak --Chimerism Following Allogeneic Transplantation of Hematopoietic Stem Cells /Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak and Michał Witt --Peritransplantation Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia /Małgorzata Dawidowska, Katarzyna Derwich and Tomasz Szczepański --Biobanks of Cellular Material /Wiesław Wiktor-Jędrzejczak and Elżbieta Urbanowska --Part 4.Molecular Diagnostic Protocols --Biobanking of Cellular Material /Anna Poluha and Elżbieta Urbanowska --Isolation of Mononuclear Cells from Human Blood and Bone Marrow by Density Gradient Centrifugation /Małgorzata Dawidowska --Molecular Techniques Commonly Used in Hemato-oncology /Monika D. Kraszewska and Ewa Ziętkiewicz --Genetic Methods of HLA Typing /Jacek Nowak, Renata Mika-Witkowska and Elżbieta Graczyk-Pol --Post-Transplant Chimerism Analysis Through STR-PCR and RQ-PCR /Małgorzata Dawidowska, Katarzyna Guz, Agnieszka Orzińska, Justyna Smolarczyk-Wodzyńska and Monika D. Kraszewska, et al. --Analysis of Minimal Residual Disease with the Use of Rearrangements of Ig/TCR Genes Through RQ-PCR /Małgorzata Dawidowska, Vincent H. J. van der Velden, Michał Witt and Tomasz Szczepański --Molecular Diagnostics of Acute Myeloblastic Leukemia /Marta Libura, Agata A. Filip and Olga Haus --Assessment of the Presence and the Level of BCR-ABL Fusion Gene Expression and Mutational Status in ABL Kinase Domain /Sylwia Czekalska, Magdalena Zawada and Izabela Florek --Studies of Rearrangements and Somatic Hypermutation of IGHV Genes in Chronic Lymphocytic Leukemia /Anton W. Langerak, Richard Rosenquist, Paolo Ghia, Chrysoula Belessi and Kostas Stamatopoulos, et al. --Molecular Biology Methods in the Diagnosis of Multiple Myeloma /Anna Dmoszyńska and Sylwia Chocholska --Molecular Methods in Myeloproliferative Neoplasms /Aleksandra Leszczyńska, Witold Prejzner, Maria Bieniaszewska and Andrzej Hellmann --Informed Consent for Participation in Research Project /Małgorzata Dawidowska and Michał Witt.
  • Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well. Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.
  • Carcinogens and mutagens -- Whole animal carcinogenicity bioassays -- Molecular mechanisms of action of selected organic carcinogens -- Binding of carinogens to DNA and covalent adducts and DNA damage - PAH, aromatic amines, nitro-aromatic compounds, and halogenated compounds -- Cellular oncogenes and carcinogenesis -- Tumor suppressor genes -- Hepatitis B, Hepatitis C, and hepatocellular carcinoma -- Oncongenesis in transgenic and knockout mice -- Chemically induced morphological and neoplastic transformation in C3H/10T1/2 C1 8 mouse embryo cells -- Radiation carcinogenesis -- DNA microarrays and computational analysis of DNA microarray data in cancer research -- Application of proteomics in basic biological sciences and cancer -- Overview of human cancer induction and human exposure to carcinogens -- Complex mixtures of chemical carcinogens: principles of action and human cancer -- Lung cancer -- Breast cancer -- Cancer of the prostate - Mechanisms of molecular carcinogenesis -- Skin cancer: epidemiology, clinical manifestations, and genetic and molecular aspects -- Cell and molecular biology of cancer of the brain --Thyroid cancer: molecular biology and clinical aspects -- Chemoprevention of chemical carcinogenesis and human cancer -- Carcinogen biomarkers and exposure assessment -- Risk assessment for chemical carcinogens -- Prevention and regulation approaches to carcinogens.
  • Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
  • Molecular diagnosis of cancer. 2nd ed. 2004, Springer Protocols
  • Molecular diagnostics 2010, CRCnetBASE
    This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.The book is the first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine. The different chapters of the book are authored by key opinion leaders, each representing their specialized areas, which provide the reader with expertise knowledge in the field.
  • Genomic Alterations in Sporadic Pancreatic Cancer /Marco Dal Molin, Anirban Maitra --Molecular Pathology of Pancreatic Cancer Precursor Lesions /Lodewijk A. A. Brosens, G. Johan Offerhaus --Genetic Epidemiology and Pancreatic Cancer /Li Jiao, Donghui Li --Translational Implications of Molecular Genetics for Early Diagnosis of Pancreatic Cancer /Michael A. Hollingsworth --The Biology of K-Ras Signaling Pathways in Pancreatic Cancer /Helen Court, Mark R. Philips, Dafna Bar-Sagi --Molecular Targeted Therapies in Pancreatic Cancer /Edward Kim, Ethan V. Abel, Arunima Ghosh --Mouse Models of Pancreatic Ductal Adenocarcinoma /Filip Bednar, Marina Pasca di Magliano --The Genetics of Pancreatic Cancer Progression /Christine A. Iacobuzio-Donahue, --Epigenetic Alterations in Pancreatic Cancer /Michael Ayars, Michael Goggins --Innovative Technologies in the Molecular Characterization of Pancreatic Cancer /Iris H. Wei, Chandan Kumar-Sinha.
  • The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing significantly. The process of molecular imaging includes key biotarget identification, design of specific molecular imaging probes, and their preclinical evaluation, e.g., in vivo using small animal studies. A multitude of such innovative molecular imaging probes have already entered clinical diagnostics in oncology. There is no doubt that in future the emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation that will optimize diagnostic processes.This handbook addresses all aspects of molecular imaging in oncology, ranging from basic research to clinical applications in the era of evidence-based medicine. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
  • 1. Brain tumors -- 2. Immunophenotypic characterizaton of infiltrating poly- and mononuclear cells in childhood brain tumors -- 3. Experimental therapies in brain tumors -- 4. Biologic anti-neoplastic therapies -- 5. The lymphokine activated killer (LAK) cell phenomenon -- 6. Angiogenesis inhibition in anti-neoplastic therapy -- 7. Antigen presentation by dendritic cells and their significance in anti-neoplastic immunotherapy -- 8. Genetically engineered antibodies for direct anti-neoplastic treatment and systematic delivery of various therapeutic agents to cancer cells -- 9. Cancer-testis antigens: promising targets for antigen directed anti-neoplastic immunotherapy -- 10. Materials and methods -- 11. Index.
  • The epidemiology of basal cell and squamous cell carcinoma / Hao Wang and Thomas L. Diepgen -- Histology of epithelial skin tumors / Jörg Reichrath and Kerstin Querings -- UV damage and DNA repair in basal cell and squamous cell carcinomas / Knuth Rass -- Papillomavirus infections and cancerogenesis of squamous cell and basal cell carcinomas / Guido Bens -- The immune system and nonmelanoma skin cancers / Elma D. Baron -- Cytogenetics of basal cell carcinoma and squamous cell carcinomas / Melanie A. Carless, Kevin J. Ashton and Lyn R. Griffiths -- The hedgehog signaling pathway and epithelial skin cancer / Julia Reifenberger -- p53 protein and nonmelanoma skin cancer / Vladislava O. Melnikova and Honnavara N. Ananthaswamy -- TGF-[beta] pathway and cancerogenesis of epithelial skin tumors / Miguel Quintanilla ... [et al.] -- PDGF pathways and growth of basal cell and squamous cell carcinomas / Jingwu Xie -- Apoptosis and cancerogenesis of basal cell and squamous cell carcinoma / Peter Erb ... [et al.] -- The role of telomerase for cancerogenesis of basal cell and squamous cell carcinomas / Eva-Maria Fabricius.
  • Theories of carcinogenesis -- Physioloigic correlates of malignancy -- Cell division and survival -- Cellular senescence -- Invasiveness -- DNA repair -- Epigenetic regulation of cancer-associated gene products -- Interaction of the groups of cancer-related gene products -- Structural growth control -- The organ preference of metastasis formation -- Angiogenesis -- Interactions with the immune system -- Endocrine dysregulation -- Dormancy and minimal residual disease -- Epithelial tumors -- Hematologic malignancies -- Mesenchymal tumors -- Neurologic tumors -- Tumors of serous cavities -- Embryonic tumors.
  • Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
  • Preface -- Molecular Pathology and Diagnostics of Gliomas.-Molecular Pathology and Diagnostics of Thyroid and Parathyroid Malignancies -- Molecular Pathology and Diagnostics of Breast Cancer -- Molecular Pathology and Diagnostics of Non-Small Cell Lung Carcinoma -- Molecular Pathology and Diagnostics of Colorectal Cancer -- Molecular Pathology and Diagnostics in Esophago-Gastric Cancer -- Molecular-Genetic Testing in Hepatocellular Carcinoma and Its Premalignant Conditions -- Molecular Diagnostics of Pancreatic Cancer -- Molecular Pathology and Diagnostics of Prostate Cancer -- Molecular Diagnosis of Bladder and Kidney Cancer -- Molecular-Genetic Testing in Penile, Scrotal, and Testicular Cancer -- Molecular Pathology and Diagnostics of Gynecologic Malignancies -- Molecular Pathology of Bone and Soft Tissue Neoplasms and Potential Targets for Novel Therapy -- Molecular Pathology and Diagnostics of Pancreatic Endocrine Neoplasms -- Molecular Pathology and Diagnostics of Childhood Tumors -- Molecular Pathology and Diagnostics of Cutaneous Malignancy -- Molecular Diagnostics of Lymphoid Neoplasms -- Molecular Diagnostics of Myeloid Neoplasms.
  • Section I. Molecular Pathology of Hematolymphoid Neoplasms: General Principles -- Molecular Oncogenesis / Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, and Falko Fend -- Genetic Predispositions for Hematologic and Lymphoid Disorders / Frederick G. Behm -- Prognostic Markers / David Bahler -- Cancer Stem Cells: Potential Targets for Molecular Medicine / Isabel G. Newton and Catriona H.M. Jamieson -- Gene Therapy for Leukemia and Lymphoma / Xiaopei Huang and Yiping Yang -- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression) / Richard J.Q. McNally -- Viral Oncogenesis / Alexander A. Benders and Margaret L. Gulley -- Section II. Specific Techniques and Their Applications in Molecular Hematopathology -- Techniques to Determine Clonality in Hematolymphoid Malignancies / Daniel E. Sabath -- Techniques to Detect Defining Chromosomal Translocations/Abnormalities / Jennifer J.D. Morrissette, Karen Weck, and Cherie H. Dunphy -- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease / Marie E. Beckner and Jeffrey A. Kant -- Detection of Resistance to Therapy in Hematolymphoid Neoplasms / Karen Weck -- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting / Jessica K. Booker -- Gene Expression Profiling / Cherie H. Dunphy -- Proteomics of Human Malignant Lymphoma / Megan S. Lim, Rodney R. Miles, and Kojo S.J. Elenitoba-Johnson -- Mouse Models of Hematolymphoid Malignancies / Krista M.D. La Perle and Suzana S. Couto -- Section III. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes -- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Patricia Aoun -- Marginal Zone B-Cell Lymphoma / Lynne V. Abruzzo and Rachel L. Sargent -- Lymphoplasmacytic Lymphoma / Pei Lin -- Molecular Pathology of Plasma Cell Neoplasms / James R. Cook -- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma / W. Richard Burack -- Mantle Cell Lymphoma / Kai Fu and Qinglong Hu -- Diffuse Large B-Cell Lymphomas / Cherie H. Dunphy --The Molecular Pathology of Burkitt Lymphoma / Claudio Mosse and Karen Weck -- Precursor B-Cell Acute Lymphoblastic Leukemia / Julie M. Gastier-Foster -- Molecular Genetics of Mature T/NK Neoplasms / John P. Greer, Utpal P. Davé, Nishitha Reddy, Christine M. Lovly, and Claudio A. Mosse -- Precursor T-Cell Neoplasms / Kim De Keersmaecker and Adolfo Ferrando -- Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma / Michele Roullet and Adam Bagg -- Posttransplant Lymphoproliferative Disorder / Margaret L. Gulley -- AIDS-Related Lymphomas / Amy Chadburn and Ethel Cesarman -- Chronic Myelogenous Leukemia / Dan Jones -- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms / Mike Perez and Chung-Che (Jeff) Chang -- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid, and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis / Robert P. Hasserjian -- Molecular Pathogenesis of Myelodysplastic Syndromes / Jesalyn J. Taylor and Chung-Che "Jeff" Chang -- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemias with Normal Cytogenetics / Sergej Konoplev and Carlos Bueso-Ramos -- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia / Sergej N. Konoplev and Carlos E. Bueso-Ramos -- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders / Murat O. Arcasoy and Patrick G. Gallagher -- White Blood Cell and Immunodeficiency Disorders / John F. Bastian and Michelle Hernandez -- Molecular Basis of Disorders of Hemostasis and Thrombosis / Alice Ma -- Sarcoidosis: Are There Sarcoidosis Genes? / Helmut H. Popper -- Castleman's Disease / Richard Flavin, Cara M. Martin, Orla Sheils, and John James O'Leary -- Molecular Pathology of Histiocytic Disorders / Mihaela Onciu -- Reactive Lymphadenopathies: Molecular Analysis / Dennis P. O'Malley -- Molecular Pathology of Infectious Lymphadenitides / Kristin Fiebelkorn -- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders / Kareem N. Washington, John F. Tisdale, and Matthew M. Hsieh.
  • Introduction -- Mechanisms of Gastrointestinal Carcinogenesis /Frank I. Scott, John P. Lynch -- Epithelial Neoplastic Disease -- Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers /Davendra Sohal, Antonia R. Sepulveda, Weijing Sun -- Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma /Mamoun Younes -- Molecular Pathology of Squamous Carcinomas of the Esophagus /Rohinton S. Tarapore, Jonathan P. Katz -- Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers /Shuko Harada, Antonia R. Sepulveda -- Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes /Fátima Carneiro, Carla Oliveira, Raquel Seruca -- Cancer Predisposition Syndromes of the Gastrointestinal Tract /Ian S. Hagemann, Antonia R. Sepulveda -- Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type /Asif Rashid -- Cancers of the Rectum and Anal Canal /Jenia Jenab-Wolcott, Bruce Giantonio -- Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia /Takeshi Uehara, Deqin Ma, Antonia R. Sepulveda -- Non-Epithelial Neoplastic Tumors -- Molecular Biology and Pathology of Gastrointestinal Stromal Tumors /Paul J. Zhang -- Neuroendocrine Tumors /Joseph R. Pisegna -- Metastatic Disease and Tumor Markers -- Molecular Mechanisms of Tumor Metastasis /Andrew D. Rhim, Davendra Sohal, Hiroshi Nakagawa -- Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis /Loren Joseph -- Serological Markers of Digestive Tract Cancers /Jorge L. Sepulveda.
  • Pituitary tumor classification : functionality, invasiveness, and aggressiveness -- Immunohistochemistry and electron microscopy as evaluation criteria in tumor classification in the deciphering of pituitary adenomas -- Proliferation -- Angiogenesis -- Apoptosis -- Signal transduction -- Stem cell markers in pituitary adenomas -- MicroRNAs -- New generic tools for diagnosis: genomics and proteomics -- Therapeutic approaches: drug, surgical, and radiotherapy.
  • Molecular Pathology of Colorectal Cancer / Fred T. Bosman -- Molecular Pathology of Pancreatic Cancer / Laura D. Wood, N. Volkan Adsay and Ralph H. Hruban -- Molecular Pathology of Liver Tumors / Thomas Longerich, Kai Breuhahn and Peter Schirmacher -- Molecular Pathology of Gallbladder Cancer / Juan Carlos Roa and N. Volkan Adsay -- Molecular Pathology of Lung Cancers / Lynette M. Sholl and Neal I. Lindeman -- Molecular Pathology of Breast Cancer / Alejandro Ariel Gru and Donald Craig Allred -- Molecular Pathology of Ovarian Cancer / Kruti P. Maniar, Ie-Ming Shih and Robert J. Kurman -- Molecular Pathology of Endometrial Cancer / Xavier Matias-Guiu and Jaime Prat -- Molecular Pathology of Kidney Tumors / Sean R. Williamson, John N. Eble and Liang Cheng -- Molecular Pathology of Prostate Cancer / Bora Gurel, Riley E. Alexander, Liang Cheng and Angelo M. De Marzo -- Molecular Pathology of Urinary Bladder Cancer / George J. Netto and Liang Cheng -- Molecular Pathology of Testicular Cancer / Katharina Biermann and Leendert H. J. Looijenga -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer / Andrea Saggini and Boris Bastian -- Molecular Pathology of Head and Neck Cancer / Audrey P. Calzada, Maie A. St. John, Elliot Abemayor and David T. W. Wong -- Molecular Pathology of Soft Tissue and Bone Tumors / Neal I. Lindeman and Paola Dal Cin -- Molecular Pathology of the Central Nervous System / Brent T. Harris and Eyas M. Hattab -- Molecular Pathology of Endocrine Cancer / Ricardo V. Lloyd, Long Jin, Darya Buehler, Heather Hardin and Weihua Shan.
  • Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.
  • Integrating molecular knowledge in clinical decision-making for personalized cancer management -- Gastrointestinal stromal tumors -- Metastatic melanoma -- Ovarian cancer -- Triple-negative breast cancer -- Gastric cancer -- Pleural mesothelioma -- Lung adenocarcinoma.
  • Part 1. Hematologic Malignancies -- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia / William L. Carroll and Rob Pieters -- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia / Alejandro Gutierrez and A. Thomas Look -- Molecularly Targeted Therapy for Infant ALL / Patrick A. Brown and Carolyn A. Felix -- Targeted Therapeutic Approaches for AML / Robert J. Arceci and Donald Small -- Acute Promyelocytic Leukaemia / Andrea Biondi, Anna Maria Testi and Brenda E. S. Gibson -- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy / Jeffrey W. Taub, Yubin Ge and Yaddanapudi Ravindranath -- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML) / Jennifer O'Hara Lauchle and Benjamin S. Braun -- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics / Seth J. Corey and Jorge Cortes -- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes / Lia Gore -- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma / Megan S. Lim and Mitchell S. Cairo -- Molecular Targeting of Post-transplant Lymphoproliferative Disorders / Michael Wang and Thomas G. Gross -- Part 2. Solid Tumors -- Molecularly Targeted Therapies for Astrocytomas / Ian F. Pollack -- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer / Yoon-Jae Cho and Scott L. Pomeroy -- Future Treatments of Ependymoma / Richard J. Gilbertson -- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor / Ganjam V. Kalpana and Melissa E. Smith -- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors / Brigitte Widemann -- Molecular Therapy for Neuroblastoma / Yaël P. Mossé and John M. Maris -- Ewing's Sarcoma Family of Tumors: Molecular Targets Need Arrows / Jeffrey A. Toretsky and Aykut Üren -- Molecular Targeted Therapy for Wilms' Tumor / James I. Geller and Jeffrey S. Dome -- Molecular Therapy for Rhabdomyosarcoma / Raushan T. Kurmasheva, Hajime Hosoi, Ken Kikuchi and Peter J. Houghton -- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here? / Rosanna Ricafort and Richard Gorlick -- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology / Stephen X. Skapek.
  • Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • Monoclonal antibodies targeting EGFR/HER2 and clinical outcomes in cancer treatment / Jan B. Vermorken -- Colorectal cancer / Christian Rolfo, Giuseppe Bronte, Antonio Russo & Marc Peeters -- Breast cancer / Sevilay Altintas -- Lung cancer and genitourinary cancers / Dirk Schrijvers -- Tumors of the skin, the CNS and the head and neck / Pol Specenier -- Gynecologic cancers / Jan B. Vermorken -- Index.
  • Morphine and metastasis 2013, Springer
    This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.
  • Mortalin biology 2012, Springer
    Part 1.Structure and Function of Mortalin /Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer /Renu Wadhwa and Sunil C. Kaul --Mortalin's Machinery /Custer C. Deocaris, Sunil C. Kaul and Renu Wadhwa --The Role of Mortalin in Iron Homeostasis /Wen-I Luo and James A. Cowan --Functional Characteristics of Mortalin /Walter A. Baseler, Tara L. Croston and John M. Hollander --Part 2.Mortalin in Evolution2 Deocaris /Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis /Marie Le Pécheur, Geneviève Morrow and Robert M. Tanguay --Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes /Charles W. Walker, Ben Low and S. Anne Böttger --Mortalin and Stem Cells: A Study from Planarians /Renata Batistoni --Part 3.Mortalin in Health and Disease /Mortalin in Cell Protection from Immune Attack /Moran Saar, Oren Moskovich and Zvi Fishelson --Mortalin in Neurological Diseases /Jinghua Jin, Jing Zhang, Travis J. Cook and Jake G. Hoekstra --Loss of Mortalin Function in Parkinson's Disease-Supporting the Mitochondrial Pathway of Neurodegeneration /Lena F. Burbulla and Rejko Krüger --Hsp75/mortalin and Protection from Ischemic Brain Injury /Robin E. White, Yi-Bing Ouyang and Rona G. Giffard --Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders /Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa and Ram K. Mishra --Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis /Alberto J. L. Macario, Francesco Cappello and Everly Conway de Macario --Part 4.Mortalin and Cancer /Many Faces of Mortalin and Tid1 /Ohad Iosefson and Abdussalam Azem --Mortalin: A Positive Regulator of Centrosome Duplication and Amplification /Masayuki Kanai and Kenji Fukasawa --Mortalin Expression in Normal and Neoplastic Tissues /Angheliki Nomikos, Sinclair R. Dundas and Graeme I. Murray --Mortalin-p53 Interaction as a Target for Liver Cancer Therapy /Wen-Jing Lu, Nikki P. Lee, Renu Wadhwa and John M. Luk --Mortalin Targeting Gadgets for Cancer Therapy /Chae-Ok Yun and Renu Wadhwa --Part 5.Mortalin Based Technologies /Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term In vitro and In vivo Tracking /Toshimasa Uemura, Masanori Nishi, Sunil C. Kaul and Renu Wadhwa --Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening /Ran Gao, Zeenia Kaul, Tomoko Yaguchi and Renu Wadhwa --Cell Internalizing Anti-mortalin Antibody as a Nanocarrier /Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa and Sunil C. Kaul.
  • MRI of rectal cancer 2010, Springer
  • mTOR inhibitors in cancer treatment / Leonidas C. Platanias -- Overview and mechanism of action of mTOR inhibitors / Stéphane Oudard -- mTOR inhibitors in renal cell carcinoma / Piotr J. Wysocki -- mTOR inhibitors in hepatocellular carcinoma / Gerhard Treiber & Thomas Wex -- mTOR inhibitors in ovarian cancer / Susana M. Campos -- mTOR inhibitors in breast cancer / Ingrid A. Mayer -- mTOR inhibitors in Hodgkin's and non-Hodgkin's lymphomas / Sonali M. Smith.
  • mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
  • Mucins and cancer 2013, Future Med
    Mucins and cancer / Joyce Taylor-Papadimitriou & Joy M. Burchell -- Introduction to mucins in cancer / Michael A. McGuckin -- Changes in mucin-type O-linked glycosylation in cancer / Joy M. Burchell & Joyce Taylor-Papadimitriou -- Mucins as biomarkers in cancer / Kowa Chen, Ola Blixt & Hans H. Wandall -- Signaling from membrane mucins / Tze Wei Poh & Sandra J. Gendler -- MUC4 and membrane receptors in cancer / Kermit L. Carraway & Coralie A. Carothers Carraway -- MUC16, alias CA125 and ovarian cancer / Evangelia-Ourania Fourkala, Aleksandra Gentry-Maharaj & Usha Menon -- Mucins in metastasis / Sylvain Julien -- How mucins shape antigen-presenting cells to modify immune responses / Sandra J. van Vliet & Yvette van Kooyk -- MUC1 as a therapeutic target in cancer / Jean-Marc Limacher & Bruce Acres -- Index.
  • Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.
  • It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.
  • Multiple myeloma 2005, Springer Protocols
    Identification of malignant plasma cells by mRNA in situ hybridization / Ross D. Brown and P. Joy Ho -- The SCID-hu myeloma model / Joshua Epstein and Shmuel Yaccoby -- The 5T2MM murine model of multiple myeloma: maintenance and analysis / Karin Vanderkerken ... [et al.] -- Determination of telomerase activity and telomere length / Kai-da Wu and Malcolm A.S. Moore -- Dendritic cell/myeloma hybrid vaccine / Dajing Xia, Tim Chan, and Jim Xiang -- Genetically engineered myeloma cell vaccine / Siguo Hao, Tim Chan, and Jim Xiang -- An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors / Andrew C.W. Zannettino ... [et al.] -- Clonality detection of the expanded T-cell populations in patients with multiple myeloma / Daniel M-Y. Sze -- Detecting mismatch repair defects in myeloma / Mark Velangi ... [et al.] -- Methylation-specific polymerase chain reaction / Oliver Galm and James G. Herman -- Making sense of DNA microarray data / Wei-min Liu, Sunhee K. Ro, and Walter H. Koch.Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz ...
  • Multiple myeloma 2011, Springer
    Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
  • This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.
  • Making Myc / J. Liu and D. Levens -- Transcriptional activation by the Myc oncoprotein / M. D. Cole and M. A. Nikiforov -- Mechanisms of transcriptional repression by Myc / D. Kleine-Kohlbrecher, S. Adhikary and M. Eilers -- The mad side of the Max network : antogonizing the function of Myc and more / S. Rottmann and B. Luscher -- Structural aspects of interactions with the Myc/Max/Mad network / S. K. Nair and S. K. Burley -- Myc target transcriptomes / L. A. Lee and C. V. Dang -- c-Myc, genome instability, and tumorigenesis : the devil is in the details / M. Wade and G. M. Wahl -- Lessons learned from Myc/Max/Mad knockout mice / M. Pirity, J. K. Blanck and N. Schreiber-Agus -- Myc/Max/Mad in invertebrates : the evolution of the Max network / P. Gallant -- The mix network : evidence for a parallel Max-like transcriptional network that regulates energy metabolism / A. N. Billin and D. E. Ayer.
  • Part I. Epidemiology and clinical presentation -- Clinical presentation and differential diagnosis -- Epidemiology and etiology -- Part II. Pathology, pathophysiology and staging -- Cytogenetic diagnosis of myelodysplastic syndromes -- MDS stem cell biology -- The biology of myelodysplastic syndrome associated with Isolated del(5q) -- A personalized molecular pathogenesis of MDS -- Myelodysplastic/myeloproliferative neoplasms -- Classification and staging of myelodysplastic syndromes -- Immunophenotyping in myelodysplastic syndromes -- Prognostic models for patients with myelodysplastic syndromes -- Part III. Treatment -- Management of low-risk MIDS -- Management of high-risk myelodysplastic syndrome -- Hematopoietic cell transplantation (HCT) -- Part IV. MIDS in children -- Myelodysplastic syndrome in children.
  • Myeloid leukemia 2005, Springer Protocols
    Diagnosis and monitoring of AML1-MTG8 (ETO)-positive acute myeloid leukemia by qualitative and real-time quantitative RT-PCR / Khalid Tobal and John A. Liu Yin -- Diagnosis and monitoring of CBFB-MYH11-positive acute myeloid leukemia by qualitative and quantitative RT-PCR / Bert A. van der Reijden and Joop H. Jansen -- Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia / Jan Cools, Elizabeth H. Stover, and D. Gary Gilliland -- FLT3 mutations in acute myeloid leukemia / Hitoshi Kiyoi and Tomoki Naoe -- WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes / Daniela Cilloni, Enrico Gottardi, and Giuseppe Saglio -- Classification of AML by DNA-oligonucleotide microarrays / Alexander Kohlmann ... [et al.] -- Classification of AML using a monoclonal antibody microarray / Richard I. Christopherson ... [et al.] --Isolation of RNA and DNA from leukocytes and cDNA synthesis / Joop H. Jansen and Bert A. van der Reijden -- Cytogenetics and FISH techniques in myeloid malignancies / Lynda J. Campbell -- Overview of real-time RT-PCR strategies for quantification of gene rearrangements in the myeloid malignancies / Christophe Picard, Monique Silvy, and Jean Gabert -- Diagnosis and monitoring of chronic myeloid leukemia by qualtitative and quantitative RT-PCR / Susan Branford and Timothy Hughes -- Detection of BCR-ABL mutations and resistance to imatinib mesylate / Susan Branford and Timothy Hughes -- Deletion of the derivative chromosome 9 in chronic myeloid leukemia / Lynda J. Campbell -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR / Vincenzo Rossi, Laura Levati, and Andrea Biondi -- Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by quantitative RT-PCR / Elisa Mokany ... [et al.] --Methods for the detection of the JAK2 V617F mutation in human myeloproliferative disorders / Peter J. Campbell ... [et al.] -- Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia / Maurizio Martini, Luciana Teofili, and Luigi M. Larocca -- Chimerism analysis following nonmyeloablative stem cell transplantation / Thomas Lion and Franz Watzinger.
  • Myeloma bone disease 2010, Springer
    Clinical Presentation of Myeloma Bone Disease / Rebecca Silbermann and G. David Roodman -- Imaging of Multiple Myeloma, Solitary Plasmacytoma, MGUS, and Other Plasma Cell Dyscrasias / Ronald C. Walker, Laurie Jones-Jackson, Twyla Bartel, Tracy Brown and Bart Barlogie -- Biochemical Markers of Bone Remodeling in Multiple Myeloma / Evangelos Terpos -- Radiation Therapy in Multiple Myeloma / Joel S. Greenberger -- Surgical Management of Bone Disease / Mohamad A. Hussein -- Bisphosphonates in the Treatment of Myeloma Bone Disease / James R. Berenson -- Osteonecrosis of the Jaw / Ashraf Badros -- Murine Models of Myeloma Bone Disease: The Importance of Choice / Peter I. Croucher, Karin Vanderkerken, Joshua Epstein and Babatunde Oyajobi -- RANK Ligand Is a Therapeutic Target in Multiple Myeloma / William C. Dougall, Michelle Chaisson-Blake, Howard Yeh and Susie Jun -- Osteoclast Activation in Multiple Myeloma / Sonia Vallet and Noopur Raje -- Potential Role of IMiDs and Other Agents as Therapy for Myeloma Bone Disease / Suzanne Lentzsch -- Proteasome Inhibitors and the Wnt Signaling Pathway in Myeloma Bone Disease / Claire M. Edwards and Gregory R. Mundy -- Mechanisms Involved in Osteoblast Suppression in Multiple Myeloma / Nicola Giuliani.
  • Diagnosis and classification of the BCR-ABL1-negative myeloproliferative neoplasms -- Genetics of the myeloproliferative neoplasms -- Cytogenetic findings in classical MPNs -- Prognostic factors in classic myeloproliferative neoplasms -- Therapy of polycythemia vera and essential thrombocythemia -- Conventional and investigational therapy for primary myelofibrosis -- Hematopoietic cell transplantation for myelofibrosis -- JAK2 inhibitors for therapy of myeloproliferative neoplasms -- Blastic transformation of classic myeloproliferative neoplasms -- Eosinophilic disorders: differential diagnosis and management -- Pathogenesis, diagnosis, classification, and management of systemic mastocytosis.
  • Nanomedicine and cancer 2012, CRCnetBASE
    Nanomedicine-based use of sirna in cancer / Guillermo N. Armaiz-Pena ... [et al.] -- Nanocarriers for gene delivery / Conchita Tros de Ilarduya and Gloria Gonzalez-Aseguinolaza -- Cancer cell photothermolysis and gold nanorod surface plasmons / Cheng-Lung Chen and Yang-Yuan Chen -- Tocotrienol loaded lipid nanoparticles in cancer / Sami Nazzal and Paul W. Sylvester -- Utilization of magnetic nanoparticles for cancer therapy / Deryl L. Troyer and Stefan H. Bossmann -- Nanoparticle probes and molecular imaging in cancer / Dongfang Liu and Ning Gu -- Iron and ethylcellulose nanoplatforms for cancer targeting / José L. Arias, Margarita López-Viota, and Ma Adolfina Ruiz -- Matrix scaffolds in cancer cell biology, physiological representation and nanoscale characterisation / Hsin-ya Chien ... [et al.] -- Fluorescence nanoprobe imaging tumor by sensing the acidic microenvironment / Lu Wang and Cong Li -- Magnetic nanorings and nanotubes for cancer detection and therapy / Hai Ming Fan and Malini Olivo -- Silicon nanowire arrays and other silicon nanostructures and their clinical applications to cancer / Murugan Veerapandian and Min-Ho Lee -- Silver nanomedicine and cancer / ... [et al.] -- Nanobubbles and their putative application to cancer medicine / Tianyi M. Krupka and Agata A. Exner -- Nano-strategies in the delivery of antitumor drugs to cancer / José L. Arias -- Gene silencing with sirna encapsulated nanoparticles to overcome tumor multidrug resistance / Mansoor M. Amiji, Francis Hornicek, and Zhenfeng Duan -- Nano-flow liquid chromatography mass spectrometric analysis of glycans in cancer / S. Hunter Walker and David C. Muddiman -- Composite nano-sensor arrays technology in lung cancer / Silvano Dragonieri, Giorgio Pennazza, and Marco Santonico -- Nano arsenic oxide (As2o3)/(Fe2o3) iron oxide complexes for liver cancer / Ziyu Wang and Dongsheng Zhang -- Hepatocellular carcinoma and midkine-antisense oligonucleotide-loaded nanoparticles / Licheng Dai, Yaoxing and Zhongjing -- Nanotechnology and nanostructures applied to head and neck cancer / Erik C. Dreaden, Mostafa A. El-Sayed, and Ivan H. El-Sayed.
  • Nasopharyngeal carcinoma 2013, Springer
    Diagnosis and clinical evaluation of nasopharyngeal carcinoma / Alan Soo-Beng Khoo and Kin-Choo Pua -- Histopathological diagnosis of nasopharyngeal carcinoma : looking beyond the blue book / John Nicholls and Gerald Niedobitek -- Descriptive, environmental and genetic epidemiology of nasopharyngeal carcinoma/ -- Bing-jian feng -- Epstein-Barr virus and the pathogenesis of nasopharyngeal carcinomas / Claire Gourzones, Pierre Busson and Nancy Raab-Traub -- Acquired genetic and epigenetic alterations in nasopharyngeal carcinoma / Kwok-Wai Lo, Grace Tin-Yun Chung and Ka-Fai To -- Cellular interactions in nasopharyngeal carcinomas / Claire Gourzones ... [et al.] -- Biological tools for NPC population screening and disease monitoring / Claire Gourzones ... [et al.] -- Medical imaging of nasopharyngeal carcinomas : current tools and applications / François Bidault -- Radiotherapy of NPC : current strategies and perspectives / John Kim -- The evolving role of systemic therapy in nasopharyngeal carcinoma : current strategies and perspectives / Edwin P. Hui and Anthony T.C. Chan -- Nasopharyngeal carcinoma immunotherapy current strategies and perspectives / Corey Smith and Rajiv Khanna -- Therapeutic induction of apoptosis in nasopharyngeal carcinoma / Carlo Bastianutto ... [et al.].
  • Introduction -- The science of developing cancer therapy -- Operations, oversight, and funding of cancer clinical trials -- Physician and patient participation in cancer clinical trials.
  • Natural killer T cells 2012, Springer
    Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi ... [et al.] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes ... [et al.] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders ... [et al.] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
  • Part 1.Natural Product Drugs and Cancer Therapeutics --The Impact of Natural Products Upon Cancer Chemotherapy /A. Ganesan --Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth /Andrea T. Hooper, Frank Loganzo, Chad May and Hans-Peter Gerber --Discodermolide: Past, Present, and Future /Ross E. Longley --HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents /Lilibeth A. Salvador and Hendrik Luesch --Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates /Frank E. Koehn --Part 2.Advances in Natural Product Cancer Drug Discovery --Natural Product Scaffolds in Cancer Therapy /Christian P. Mang and Lars Ole Haustedt --The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery /Claudia Eva-Maria Unsin, Scott R. Rajski and Ben Shen --Accessing Anti-cancer Natural Products by Plant Cell Culture /Lisa M. Leone and Susan C. Roberts --Natural Products as Tools for Discovering New Cancer Targets /John A. Beutler.
  • Neoadjuvant therapy in breast cancer / Mario Campone & Jean-Sébastien Frenel -- Ask the experts : neoadjuvant therapy : current options / Mark Beresford -- Evaluation of complete pathologic response / Audrey Mailliez, Géraldine Lauridant-Philippin & Jacques M Bonneterre -- Recommendation and predictors of pathologic response / Vladimir F. Semiglazov & Vladislav V. Semiglazov -- Combination chemotherapy and targeted agents / Victoria Brown & Stephen Chan -- Role of radiation after neoadjuvant chemotherapy / Michelle A. Kraay & Janice A. Lyons -- Monoclonal antibody therapy / Jean-Sébastien Frenel & Mario Campone -- Multiple choice questions : answers.
  • Neoplastic Diseases of the Blood" integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia - Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.
  • Neuro-oncology Part I-II pt. I-II, 2012., ScienceDirect
    pt. II ScienceDirect
  • Neuroblastoma 2012, Springer
  • Neuroblastoma 2005, Springer
  • Neuroendocrine tumors 2011, Springer
    Global epidemiology of neuroendocrine tumors -- Pathology -- Multiple endocrine neoplasia -- Other genetic syndromes -- Imaging of neuroendocrine tumors -- Surgical management of sporadic gastrointestinal neuroendocrine tumors -- Management of neuroendocrine tumor hormonal syndromes -- Management of metastatic carcinoid tumors -- Medical management of islet cell carcinoma -- Poorly differentiated neuroendocrine tumors -- Hereditary and sporadic medullary thyroid carcinoma -- Adrenocortical carcinoma -- Pheochromocytoma -- Merkel cell carcinoma.
  • Neurofibromatoses 2008, Karger
    The neurofibromatoses: classification, clinical features, and genetic counselling / S.M. Huson -- Treatment and management of neurofibromatosis 1 / V.F. Mautner, E. Boltshauser -- Neurofibromatosis type 1 and other syndromes of the Ras pathway / D.A. Stevenson, J.J. Swensen, D.H. Viskochil -- NF1 gene structure and NF1 genotype/phenotype correlations / M. Upadhyaya -- NF1 mutational spectrum / L.M. Messiaen, K. Wimmer -- Clinical phenotypes in patients with NF1 microdeletions / S. Tinschert --Structure of the NF1 gene region and mechanisms underlying gross NF1 deletions / H. Kehrer-Sawatzki -- NF1 gene evolution in mammals / G. Assum, C. Schmegner -- Structure and function of neurofibromin / S. Welti, I. D'Angelo, K. Scheffzek -- Composition of neurofibromas, NF1 expression, and comparison of normal and NF1 haploinsufficient cells / J. Peltonen, S. Peltonen -- Somatic NF1 mutations in tumors and other tissues / T. De Raedt ... [et al.] -- NF2: mutations and management of disease / D.G.R. Evans, A. Wallace -- Function of merlin in genesis of tumours and other symptoms of NF2 / C.O. Hanemann -- Molecular studies on schwannomatosis / L. Kluwe.
  • Neurofibromatosis 1 -- Neurofibromatosis Type 2 (NF2) -- The Neurofibromatoses: Differential Diagnosis and Rare Subtypes -- Psychological Impact of the Neurofibromatoses -- Clinical Quiz: Diagnostic and Management Pitfalls of Neurocutaneous Disease.
  • Neurofibromatosis type 1 2012, Springer
    Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.Neurofibromatosis Type 1: Molecular and Cellular Biology will be of great value to medical geneticists, molecular and cellular biologists, oncologists, dermatologists, neurologists, genetic counsellors and general practitioners alike.
  • Neuronal development / K.M. Giehl -- Organization of peripheral nerves in skin, musculoskeletal system, and viscera / M. von Düring, B. Fricke -- Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis / H.M. Schuller -- Neuronal markers in non-neuronal tissues / C. Hagel, D. Stavrou -- Chemotropic axon guidance molecules in tumorigenesis / A. Chédotal -- Neoneurogenesis and the neuro-neoplastic synapse / D. Palm, F. Entschladen -- Neurotransmitter effects on tumor cells and leukocytes / K. Lang, P. Bastian -- Stem cells and neurogenesis in tumors / J.A. Varner -- Potential inhibition of the neuro-neoplastic interactions: the clue of a GPCR-targeted therapy / J.-M. Muller -- The neuro-neoplastic synapse: does it exist? / K.S. Zänker.
  • Neutron capture therapy 2012, Springer
  • Nevogenesis 2012, Springer
  • Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
  • The relationship between oncologists and their cancer patients is rapidly evolving. Oncologists and other cancer professionals master new anticancer and supportive treatment options, while working under increasing economic pressure and time constraints, and are often unprepared to deal with all the challenges of their new position in a therapeutic relationship with cancer patients and families. Good communication is as essential as are modern laboratory tests and sophisticated diagnostics to achieve the best clinical results. This book updates the evolution of truth-telling and communication patterns worldwide and offers insights into the recent trends and emerging challenges in communication with cancer patients and families. New Challenges in Communication with Cancer Patients is an invaluable resource to medical professionals, educators and patients in establishing a strong and effective partnership built on trust and mutual understanding.
  • Epidemiology, clinical aspects and pathology -- Epidemiology, risk factors and clinical presentation -- Pathology and genetics -- Diagnosis -- Ultrasound -- Case for MDCT -- Case for MRI -- Endoscopic ultrasonography in pancreatic tumors: when and why? -- PET/CT in pancreatic cancer -- Cost decision analysis for diagnosing and staging -- Therapy -- Case for surgery -- Locally advanced nonmetastatic cancer -- Metastatic pancreatic cancer: systemic therapy -- Role of interventional endoscopy -- Local ablative techniques in the treatment of locally advanced pancreatic cancer.
  • Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS) / P. Picci ... [et al.] -- Targeted therapies in Ewing's sarcoma / K. Scotlandi -- The CCN3 protein and cancer / B. Perbal -- EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage / J. Ban ... [et al.] -- Molecular karyotyping in sarcoma diagnostics and research / H. Vauhkonen ... [et al] -- TuBaFrost: European virtual tumor tissue banking / P.H.J. Riegman ... [et al] -- Virtual microscopy in virtual tumor banking / M. Isabelle ... [et al] -- Harmonizing cancer control in Europe / U. Ringborg -- The diagnosis of cancer: from H&E to molecular diagnosis and back / J. Costa -- From morphological to molecular diagnosis of soft tissue tumors / M. Miettinen -- Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract / H. Höfler ... [et al] -- Integrating the diagnosis of childhood malignancies / D. López-Terrada -- Preclinical models for cell cycle-targeted therapies / M. Malumbres -- WWOX, a chromosomal fragile site gene and its role in cancer / D. Ramos and C.M. Aldaz -- From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis / J.K. Habermann ... [et al] -- Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models / L. Holmquist, T. Löfstedt, and S. Påhlman -- Methylation patterns and chemosensitivity in NSCLC / J.L. Ramírez ... [et al] -- Pharmacogenomics and colorectal cancer / H.J. Lenz -- Development of pharmacogenomic predictors for preoperative chemotherapy of breast cancer / L. Pusztai -- Vascular endothelial growth factor inhibitors in colon cancer / E. Díaz-Rubio -- Molecular imaging of cancer using PET and SPECT / A. Kjær -- MRS as endogenous molecular imaging for brain and prostate tumors: FP6 project "eTUMOR" / B. Celda ... [et al] -- From Linac to tomotherapy: new possibilities for cure? / G. Storme ... [et al] -- Targeting mTOR for cancer treatment / B. Rubio-Viqueira and M. Hidalgo -- Dual/pan-her tyrosine kinase inhibitors: focus in breast cancer / J. Albanell -- Antitumor-associated antigens IGGS: dual positive and negative potential effects for cancer therapy / E. Barberá Guillem and J.W. Sampsel -- Synergistic molecular mechanisms in hormone-sensitive breast cancer / A. Llombart Cussac.
  • This book describes in detail three different techniques for minimally invasive video-assisted breast surgery: nipple-sparing mastectomy with a hand-held external retractor, with a single-port device, and with robotic assistance. All three techniques can be employed for radical treatment of breast cancer or for risk reduction surgery, and the last two are brand new. The techniques are clearly explained with the aid of numerous high-quality illustrations. All surgical stages are covered in detail, and helpful information is provided on key aspects of surgical anatomy, diagnostic workup, instrumentation, and postoperative management. Nipple Sparing Mastectomy is the first manual to cover these techniques, which are likely to become standard in the field of oncological breast surgery. It will be invaluable for breast surgeons who are skilled in nipple-sparing mastectomy and oncoplastic techniques or are working in breast units that offer genetic counseling to high-risk patients.
  • Nitric oxide and cancer: an overview -- A role for eNOS in oncogenic Ras-driven cancer -- Dual role of nitric oxide in cancer biology -- Nitric oxide expression in cancer -- S-nitrosylation: how cancer cells say NO to cell death -- Cytotoxic and protective activity of nitric oxide in cancers -- Cytotoxic/protective activity of nitric oxide in cancer -- Nitric oxide and life or death of human leukemia cells -- Inhibition of apoptosis by endogenous nitric oxide in chronic lymphocytic leukaemia -- Nitric oxide: a rate-limiting factor for metastases development -- Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB/Snail/RKIP loop -- Sensitizing effect of nitric oxide to cytotoxic stimuli -- Nitric oxide is a promising enhancer for cancer therapy -- Role of nitric oxide for modulation of cancer therapy resistance -- Breaking resistance: role of nitric oxide in the sensitization of cancer cells to chemo- and immunotherapy -- Prognostic significance of iNOS in human melanoma -- Prognostic significance of iNOS in hepatocellular carcinoma -- Prognostic significance of iNOS in esophageal cancer -- Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis -- Nitric oxide-releasing molecules for cancer therapy and chemoprevention -- Nitric oxide: monotherapy or sensitiser to conventional cancer treatments? -- Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies -- (S, R)-3-Pheynyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO): new dress for nitric oxide mission -- Nitric oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis -- Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of nitric oxide of HIF-1a: potential role of Se-Methylselenocysteine(MSC), an antioxidant multi-targeted small molecule.
  • Non-Hodgkin lymphoma 2013, Springer
    Biology --Cancer Stem Cells: A Matter of Perspective /Peter J. Quesenberry, J. Reagan, B. Ramratnam, L. Goldberg --B and T Cell Development /Loren D. Fast --HIV Lymphomagenesis /Liron Pantanowitz, Antonino Carbone --Epstein-Barr Virus Lymphomagenesis and Therapeutic Targets /Huilan Rao, Roberto N. Miranda --Antigen-Driven Lymphomagenesis /Reve Shields, James N. Butera --Preclinical Modeling in Lymphoid Malignancies /Richa Dawar, Francisco J. Hernandez-Ilizaliturri --Prognostic Factors --Prognostic Factors in B-Cell Lymphomas /Diana O. Treaba, Diana O. Treaba --Prognostic Factors in Peripheral T-Cell Lymphomas /Brady E. Beltran, Jorge J. Castillo --Prognostic Factors in HIV-Associated Lymphoma /Jodi L. Layton, Jorge J. Castillo --Therapy --Future Directions in Aggressive Lymphomas /Guilherme F. Perini, Luis E. Fayad --New Monoclonal Antibodies for Indolent Non-Hodgkin Lymphoma /Tadeusz Robak --Current Therapies for T-cell Lymphomas /Francine M. Foss --Overview of Stem Cell Transplantation for Lymphoma /Karen Ballen --Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas /Natthapol Songdej, Eric S. Winer --The Role of Hematopoietic Stem Cell Transplantation for HIV-Associated Lymphomas /Pascual Balsalobre, David Serrano, Jorge Gayoso, Juan Berenguer, José L. Díez-Martín --The Role of Hematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphomas /Jenna D. Goldberg, Carla Casulo, Steven M. Horwitz.
  • Non-Hodgkin lymphomas 2013, Future Med
    Non-Hodgkin lymphomas : advanced diagnostics and personalized therapies / Antonino Carbone & Anas Younes -- Lymphoma classification : past, present and future / Stefano A. Pileri, Claudio Agostinelli, Elena Sabattini, Francesco Bacci, Carlo Sagramoso, Alessandro Pileri Jr., Brunangelo Falini & Pier Paolo Piccaluga -- Immunophenotyping of non-Hodgkin lymphomas / Annunziata Gloghini & Laurence de Leval -- Pathologic diagnosis : molecular genetics / Francesco Bertoni -- Flow cytometry immunophenotyping: minimal residual disease / Pietro Bulian & Cristina Feruglio -- PET imaging / Nicolas Mounier & Nihal Martis -- Staging and prognosis / Matthew Lunning & James O. Armitage -- Which therapies for which patients / Meghan Karuturi & Anas Younes -- Chemotherapy modalities and algorithms / Chaitra Ujjani & Bruce D. Cheson -- Radiation therapy / Mauro G. Trovò & Carlo Furlan -- Cancer vaccines and active immunotherapy / Roberta Zappasodi, Paola Filipazzi, Licia Rivoltini & Massimo Di Nicola -- Stem cell transplantation in non-Hodgkin lymphomas / Jonathan Friedberg & Shahrukh Hashmi -- B-cell chronic lymphocytic leukemia/lymphoma / Piers E.M. Patten, Charles C. Chu & Nicholas Chiorazzi -- Follicular lymphoma / Stefano Luminari, Alessandra Dondi, Irene Biasoli & Massimo Federico -- Mantle cell lymphoma / Kathrin Aprile von Hohenstaufen, Alden Moccia & Emanuele Zucca -- MALT lymphoma : extranodal marginal zone B-cell lymphoma of MALT / Anastasios Stathis, Francesco Bertoni, Emanuele Zucca & Franco Cavalli -- Mycosis fungoides and other cutaneous T-cell lymphomas / Dario Tomasini, Marco Lucioni, Marco Paulli & Emilio Berti -- Peripheral T-cell lymphoma / David Sibon & Christian Gisselbrecht -- Management of elderly patients with diffuse large B-cell lymphomas / Michele Spina, Rosanna Ciancia & Umberto Tirelli -- Virus-associated non-Hodgkin lymphomas / Paolo De Paoli & Antonino Carbone -- Intrafollicular neoplasia/in situ lymphoma / Antonino Carbone & Annunziata Gloghini -- Index.
  • Apoptosis Inducer from Streblus asper Extracts for Cancer Chemoprevention /Azman Seeni, Nur Ayunie Zulkepli and Ridhwan Abdul Wahab --Apoptosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Signaling Networks /Nagini Siddavaram and Vidya Priyadarsini Ramamurthi --Heterocyclics as Inducers of Apoptosis /Ahmed Kamal, Adla Mallareddy and Paidakula Suresh --Anthocyanins as Apoptotic Regulators /Jairam Vanamala, Sridhar Radhakrishnan, Lavanya Reddivari and Aaron Massey --Apoptosis as a Mechanism Involved in the Anticancer Effect of Dietary n-3 Polyunsaturated Fatty Acids /Simona Serini, Elena Fasano, Elisabetta Piccioni, Achille Renato Maria Cittadini and Gabriella Calviello --Apoptotic Pathways upon Arsenite Treatment /Dongyun Zhang and Chuanshu Huang --Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges /Danielle D. Jandial, Anne R. Simoneau and Xiaolin Zi --Progesterone Receptor Modulators Induce Apoptosis in Mammary Tumors and Uterine Leiomyomas /Konstantin Christov and Ronald D. Wiehle --Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma /Subhadeep Das and Malay Chatterjee --Curcumin Analogs as Inhibitors of the Jak-STAT Signal Transduction Pathway /Jennifer Yang and Gregory B. Lesinski --Targeting Cancer by Betulin and Betulinic Acid /René Csuk.
  • Part 1.Basic Science and Experimental Studies on Stem Cell Mobilization --Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells --Molecular Pharmacology of CXCR4 Inhibition --Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors --Should We Stay or Should We Go Now? --Cell Adhesion and Mobilization Pathways of Hematopoietic Cells --Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking --Part 2.Clinical Studies on Stem Cell Mobilization --Front matter --Early Studies of AMD3100/Plerixafor in Healthy Volunteers --The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation --Experience with Apheresis Procedures After Plerixafor Mobilisation --Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation --Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and Non-Hodgkin's Lymphoma --Plerixafor: Data from the Compassionate Use Program --Stem Cell Mobilization with Chemomobilization Plus Plerixafor in Hard-to-Mobilize Patients: The Experience at Kuopio University Hospital, Finland --Blood Stem Cell Mobilization in Solid Tumors: Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization --Mobilization with Chemotherapy + G-CSF + Plerixafor in Europe: The Italian Experience --Experience with Plerixafor in Poor Mobilizers --CXCR4 Antagonists --Part 3.CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors --Front matter --Application of CXCR4 Inhibitors in Leukemia --CXCR4 Antagonists for the Treatment of CML --Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience --CXCR4-Blockade for Treatment of Breast Cancer --Molecular Imaging of CXCR4 Receptor Expression in Tumors --Part 4.Novel applications --Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells --Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation --Mobilization for Gene Therapy.
  • Nuclear oncology 2013, Springer
    Nuclear Oncology: Pathophysiology and Clinical Applications is a comprehensive textbook covering the increasing role of radionuclide-based technologies in the management of oncologic patients, with disease-oriented chapters giving a detailed overview of current indications and developments. Topics covered include instrumentation, physics, radiobiology, radioguided surgery, and radionuclide therapy, which is discussed with useful separate topics describing the importance of organ function assessment after cancer therapies in the heart, lung, kidney and the gastro-intestinal tract. Additionally, significant aspects of cancer biology and molecular imaging are discussed, as well as appropriate tracers for both single- and positron-emitting radionuclides. Individual chapters in the book focus on the most common cancers occurring in adults and children, detailing radionuclide procedures within an integrated framework identifying the information required for effective treatment of specific tumors. These clinical chapters provide a description of the epidemiology, etiology, histologic and pathophysiologic classification, prognosis, treatment, and most common outcome for each type of cancer. With contributions from a group of internationally-distinguished practitioners, Nuclear Oncology: Pathophysiology and Clinical Applications serves as a valuable compendium of knowledge for nuclear medicine physicians and radiologists and other clinicians involved in the care and management of cancer patients.
  • Criteria and classification of obesity in Japan and Asia-Oceania / M. Kanazaw ... [et al.] - Exercise and obesity in China / C. Chang -- Obesity in childhood: the Greek experience / A. Kafatos, C.A. Codrington, M. Linardakis -- Epidemiology of physical activity from adolescence to young adulthood / D.J. Aaron, Y.S. Jekal, R.E. Laporte -- Adolescent obesity and physical activity / N. Hwalla, A.M. Sibai, N. Adra -- Nutrition and physical activity of the population in Serbia / M. Pavlovic, V. Grujic, A. Oshaug -- Physical activity and body composition / D. Andreoli, A. De Lorenzo -- Syndrome X: clinical aspects / D. Labadarios -- Metabolic syndrome: is there a pathophysiological common denominator?: lessons learned from the Pima Indians / P.A. Tataranni -- Lifestyle-gene-drug interactions in relation to the Metabolic syndrome / L. Storlien ... [et al.] -- Coronary heart disease, genetics, nutrition and physical activity / M.B. Donati, I. Iacoviello -- Role of nutrients and physical activity in gene expression / R. De Caterina, R. Madonna -- Physical activity and hypertension: an overview / G.P. Rontoyannis --Omega-3 fatty acids and ventricular arrhythmias / A. Leaf, J.X. Kang, Y.-F. Xiao -- A method for the direct evaluation of the fatty acid status in a drop of blood from a fingertip in humans: application to population studies and correlations with biological parameters / F. Marangoni, C. Colombo, C. Galli -- Measurement error in the assessment of interaction between dietary and genetic factors in cohort studies of cancer / S.A. Bingham -- Cancer frequency in poor rural communities consuming a very limited diet / M. Muñoz Rivera ... [et al.] -- Omega-6/omega-3 polyunsaturated fatty acids ratio and breast cancer / P. Bougnoux, V. Maillard, V. Chajés -- Fish, [omega]-3 polyunsaturated fat intake and cancer at selected sites / A. Tavani ... [et al.] -- Cancer risk reduction by physical exercise / A. Willer.
  • Aberrant Signaling Pathways in Cancer: Modulation by the Dietary Flavonoid, Quercetin /Ramamurthi Vidya Priyadarsini and Siddavaram Nagini --Micronutrients and Cancer: Add Spice to Your Life /Sahdeo Prasad, Subash C. Gupta and Bharat B. Aggarwal --Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics /Laura M. Beaver, David E. Williams, Roderick H. Dashwood and Emily Ho --Molecular Insight and Preclinical Perspective of Thymoquinone as Chemopreventive Agent and Therapeutic Adjunct in Cancer /Sanjeev Banerjee, Mansi Parasramka, Fazlul H. Sarkar and Ramzi M. Mohammad --Dietary Biofactors in the Management of Cancer: Myth or Reality? /Vidushi S. Neergheen-Bhujun, K. S. Kang, O. I. Aruoma and T. Bahorun --Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition /Kristin Landis-Piwowar, Elizabeth Smerczak, Jian Zuo and Q. Ping Dou --STAT Signaling in Cancer Prevention /Su-Ni Tang, Sharmila Shankar and Rakesh K. Srivastava --[gamma][delta] T Cells, Tea and Cancer /Jingwei Lu, Vincent J. Pompili and Hiranmoy Das --Phytochemical Intakes with a Mediterranean Diet: Levels Achievable with an Exchange List Diet and Potential Biomarkers in Blood /Zora Djuric --Plant Polyphenols and Their Role in Cancer Prevention and Chemotherapy /Sharmila Shankar, Brahma N. Singh and Rakesh K. Srivastava --Role of Food Micro-molecules in the Prevention of Cancer /Latha Sabikhi, Alok Jha, Sudhir Kumar Tomer and Ashish Kumar Singh.The Protective Role of Zinc in Cancer: A Potential Chemopreventive Agent /Bin Bao, Amir Ahmad, Azfar S Azmi, Zhiwei Wang and Sanjeev Banerjee, et al. --Diet-Induced Epigenetic Changes and Cancer Prevention: A Mantra for Healthy Living /Ajay Goel and Gaurav Chaturvedi --Western Diet-Induced Pancreatic Cancer /M. Mura Assifi and Guido Eibl --Intracellular Signaling Network as a Prime Chemotherapy Target of Green Tea Catechin, (-)-Epigallocatechin-3-gallate /Brahma N. Singh, Sharmila Shankar and Rakesh K. Srivastava --Role of Dietary Antioxidants in Cancer /C. M. Ajila and S. K. Brar --Curcumin: Structure, Biology and Clinical Applications /Sharmila Shankar and Rakesh K. Srivastava --Obesity, Cancer and Psychopathology: Can Vegetarian Diet Be of Help? /Vikas Kumar, Ajit Kumar Thakur and Shyam Sunder Chatterjee --Dietary Phytochemicals as Epigenetic Modulators in Cancer /Vijay S. Thakur and Sanjay Gupta --Modulation of the Nrf2 Signaling Pathway by Chemopreventive Dietary Phytoconstituents /Altaf S. Darvesh and Anupam Bishayee --Role of Fish Oil from Gene Expression to Pharmacological Effect in Cancer Prevention /Malay Chatterjee, Subhadeep Das, Mary Chatterjee and Kaushik Roy --Antioxidant Supplements: An Evidence-Based Approach to Health Benefits and Risks /Goran Bjelakovic, Dimitrinka Nikolova and Christian Gluud --Natural Antioxidants and Their Role in Cancer Prevention /Akanksha Singh, Akansha Jain, Birinchi Kumar Sarma, Alok Jha and H. B. Singh --Dietary and Non-dietary Phytochemicals in Cancer Control /Dhanir Tailor and Rana P. Singh.
  • Assessment of Malnutrition and Nutritional Therapy Approaches in Cancer Patients --Cancer Anorexia (CA) --Cancer Cachexia (CC) --Oral Mucositis --Nausea and Vomiting in Cancer --Cancer-Related Fatigue (CRF) --Treatment-Induced Enteritis (Radiation- or Combination Therapy-Induced Enteropathies) --Neurocognitive Impairment (NI) --Dysfunction of the Bowel/Constipation --Dysphagia.
  • Nutritional oncology. 2nd ed. 2006, ScienceDirect
  • In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.
  • This book a conjoint effort of ocular oncologists, general oncologists, and pathologists is a comprehensive source of authoritative information on the subject of ocular and adnexal lymphoma. It covers all aspects, including clinical features, classification, epidemiology, diagnostic evaluation, biopsy techniques, histology and molecular pathology, staging procedures, and treatment methods. Detailed information is provided on primary vitreoretinal and adnexal lymphomas and chapters are also included on rare variants such as T cell lymphoma and reactive lymphoid hyperplasia of the ocular adnexa. The emphasis throughout is on easy readability, and the layout ensures rapid retrieval of information. In order to convey fundamental concepts, numerous tables, clinical photographs, histopathologic microphotographs, and imaging studies (fluorescein and indocyanine angiograms, ultrasonograms, CT scans, and MR images) are included.
  • Oncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information. As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably. Oncofertility Communication describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field.
  • Part I. The Science and Technology of Oncofertility -- Reproductive health after cancer -- Designing follicle-environment interactions with biomaterials -- Gamete preservation -- To transplant or not to transplant: that is the question -- Clinical cases in oncofertility -- Cancer genetics: risks and mechanisms of cancer in women with inherited susceptibility to epithelial ovarian cancer -- Protecting and extending fertility for females of wild and endangered mammals -- -- Part II. Historical and Legal Perspectives -- Placing the history of oncofertility -- Medical hope, legal pitfalls: potential legal issues in the emerging field of oncofertility -- Domestic and international surrogacy laws: implications for cancer survivors -- -- Part III. Clinical and Theoretical Ethics -- Adoption after cancer: adoption agency attitudes and perspectives on the potential to parent post-cancer -- Ovarian tissue cryopreservation and bioethical discourse -- Lessons of oncofertility for assisted reproduction -- Morally justifying oncofertility research -- Ethical dilemmas in oncofertility: an exploration of three clinical scenarios -- Participation in investigational fertility preservation research: a feminist research ethics approach -- Reproductive "choice" and egg freezing -- Impact of infertility: why ART should be a higher priority for women in the global south -- Oncofertility and informed consent: addressing beliefs, values, and future decision making -- -- Part IV. Religious Perspectives -- Bioethics and oncofertility: arguments and insights from religious traditions -- Sacred bodies: considering resistance to oncofertility in Muslim communities -- Unlikely motherhood in the Qur'an: oncofertility as devotion -- Technology and wholeness: oncofertility and Catholic tradition -- Jewish perspectives on oncofertility: the complexities of tradition -- --Part V. Ramifications for Education and Economics -- Oncofertility Saturday academy: a paradigm to expand the educational opportunities and ambitions of high school girls -- Myoncofertility.org: a web-based patient education resource supporting decision making under severe emotional and cognitive overload -- Anticipating ovarian tissue cryopreservation in the health-care marketplace: a willingness to pay assessment -- Perspectives on oncofertility from demography and economics -- For the sake of consistency and fairness: why insurance companies should cover fertility preservation treatment for iatrogenic infertility -- -- Part VI. Repercussions of Oncofertility for Patients and Their Families -- Health provider perspectives on fertility preservation for cancer patients -- Counseling and consenting women with cancer on their oncofertility options: a clinical perspective -- Fertility-related treatment choices of cancer patients: cancer-related infertility and family dynamics -- Whose future is it?: ethical family decision making about daughters' treatment in the oncofertility context -- -- Part VII. Healthcare Provider Stories and Final Thoughts -- Choosing life when facing death: understanding fertility preservation decision-making for cancer patients -- Discussing fertility preservation with breast cancer patients -- Warning: Google can be hazardous to your health: fertility preservation is an important part of cancer care -- Role of a patient navigator in fertility preservation -- Judaism and reproductive technology -- Reading between the lines of cancer and fertility: a provider's story -- Rewarding experience for a pediatric urologist -- Final thoughts.
  • Part I. Introduction --The emergence of a new discipline: oncofertility /Teresa K. Woodruff --Part II. Fertility risk and treatment options --Fertility management for women with cancer /Sanjay K. Agarwal and R. Jeffrey Chang --Fertility preservation in adult male cancer patients /Robert E. Brannigan --Managing fertility in childhood cancer patients /Kimberley J. Dilley --Fertility risk in pediatric and adolescent cancers /Clarisa R. Gracia and Jill P. Ginsberg --Part III. Oncofertility techniques and research --Bioengieneering and the ovarian follicle /Min Xu, Teresa K. Woodruff, and Lonnie D. Shea --The science of cryobiology /Steven F. Muller and John K. Critser --Ovarian tissue cryopreservation and transplantation: banking reproductive potential for the future /David Lee --Progress, history and promise of ovarian cryopreservation and transplantation for pediatric cancer patients /Yasmin Gosiengfiao --Part IV. Health care decision-making --Oncofertility and the social sciences /Karrie Ann Snyder --Shared decision making: fertility and pediatric cancers /Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston --Part V. Ethical and psychosocial impact of cancer-related infertility --Today's research, tomorrows cures: the ethical implications of oncofertility /Leilah E. Backhus and Laurie Zoloth --The psychosocial context of cancer-related infertility /Matthew J. Loscalzo and Karen L. Clark --Childhood cancer: fertility and psychosocial implications /Karen E. Kinahan, Aarati Didwania, and Carrie L. Nieman --Fertility preservation and adolescent cancer patients: lessons from adult survivors of childhood cancer and their parents /Carrie L. Nieman ... [et al.] --Part VI. Training in a new medical discipline and medical guidelines --Oncofertility: a new medical discipline and the emerging scholar /Laxmi A. Kondapalli --Oncofertility Consortium consensus statement: guidelines for ovarian tissue cryopreservation /Leilah E. Backhus ... [et al.] --Part VII. Patient stories and oncofertility --Personal accounts of cancer and infertility /provided by Fertile Hope.
  • Oncogenomics handbook 2005, Springer
  • Oncologic breast surgery 2014, Springer
    This book presents the most recent developments in oncologic breast surgery and takes full account of diagnostic, pathologic, and radiologic inputs. It is divided into three parts, the first of which discusses the premises underlying the modern surgical approach to breast cancer. The second part is devoted to what might be termed the conservative program, i.e., breast conservation and oncoplastic surgery, conservative mastectomy, and sentinel node biopsy and axillary dissection. The final part of the book covers different forms of surgery and other treatments in particular settings. Topics include plastic and reconstructive surgery, DCIS surgery, radio-guided surgery, adjuvant systemic therapy, intraoperative radiotherapy, and the role of surgery in locally advanced and metastatic disease. The detailed descriptions of techniques are accompanied by numerous high-quality illustrations. This book will be of value to both experienced practitioners and surgical trainees. .
  • Oncologic imaging 2012, ScienceDirect
  • Oncology 2006, Springer
    Sect. 1. Principles of oncology. Evidence-based approach to oncology -- Principles of chemotherapy -- Principles of radiation oncology -- Principles of surgical therapy in oncology -- Principles of targeted and biological therapies -- Biologic principles of hematopoietic stem cell transplantation -- Evaluation of tumor markers: an evidence-based guide for determination of clinical utility -- Design and analysis of oncology clinical trials -- Ethics of clinical oncology research -- Informatics infrastructure for evidence-based cancer medicine -- Economics of cancer care -- Principles of screening for cancer -- Patient decision making -- Establishing an interdisciplinary oncology team -- Principles of complementary and alternative medicine for cancer -- Sect. 2. Translational basic science. Fundamental aspects of the cell cycle and signal transduction -- Viral carcinogenesis -- Environmental carcinogenesis -- Cancer metastasis -- Tumor immunology and immunotherapy -- Technologies in molecular biology: diagnostic applications -- Sect. 3. Cancer prevention and control. Cancer epidemiology -- Evidence-based cancer prevention research: a multidisciplinary perspective on cancer prevention trials -- Screening --Genetic screening and counseling for high-risk populations -- Behavior modification -- Sect. 4. Cancer imaging. Central nervous system imaging -- Breast imaging -- Imaging of throacic malignancies -- Imaging of gastrointestinal stromal tumor -- Genitourinary imaging -- Musculoskeletal imaging -- Positron emission tomography and cancer -- Sect. 5. Solid tumors. Central nervous system tumors -- Eye, orbit, and adnexal structures -- Head and neck cancer -- Lung cancer -- Therapy for malignant pleural mesothelioma -- Mediastinum -- Esophageal cancer -- Stomach -- Colon, rectal, and anal cancer management -- Adenocarcinoma and other small intestinal malignancies -- Cancer of the lung and bile ducts -- An evidence-based approach to the management of pancreatic cancer -- Renal cell cancer -- Ureter, bladder, penis, and urethra -- Prostate cancer -- Testis cancer -- Cervix, vulva, and vagina -- Gastational trophoblastic neoplasms -- Ovarian cancer -- Uterine malignancies -- Evidence-based management of breast cancer -- Thyroid and Parathyroid -- Tumors of the endocrine system -- Sarcomas of bone -- Soft tissue sarcoma --Cutaneous melanoma -- Nonmelanoma cutaneous malignancies -- Cancer of unknown primary site -- Solid tumors of childhood -- Sect. 6. Hematologic malignancies. Acute myeloid leukemia and the myelodysplastic syndromes -- Acute lymphoblastic leukemia -- Chronic lymphocytic leukemia and related chronic leukemias -- Chronic myeloid leukemia -- An evidence-based approach to the management of Hodgkin's lymphoma -- The non-Hodgkin's lymphomas -- Multiple myeloma -- Sect. 7. Practice of oncology. Superior vena cava syndrome -- Central nervous system emergencies -- Metabolic emergencies in oncology -- Surgical emergencies -- Oral complications of cancer therapy -- Alopecia and cutaneous complications of chemotherapy -- Infectious complications of cancer therapy -- Acute toxicities of therapy: pulmonary complications -- Cardiac complications -- Neurologic complications of therapy -- Acute toxicities of therapy: urologic complications -- Issues in vascular access with special emphasis on the cancer patient -- Management of cancer pain -- Nausea and vomiting in the cancer patient -- Nutritional support for the cancer patient --Paraneoplastic syndromes -- Malignant effusions -- Evidence-based use of hematopoietic growth factors for optimal supportive care of patients with cancer -- Management of the bone marrow transplant patient -- Management of anxiety and depression in adult cancer patients: toward an evidence-based approach -- Reproductive complications and sexual dysfunction in the cancer patient -- Metastatic cancer to the central nervous system -- Metastatic cancer in lung -- Surgical and regional therapy for liver metastases -- Metastatic cancer to bone -- Cancer in the immunosuppressed patient -- Cancer in the older population -- Chemotherapy in patients with organ dysfunction -- Management of the pregnant cancer patient -- Sect. 8. Cancer survivorship. Survivorship research: past, present, and future -- Late effects of cancer treatments -- Medical and psychosocial issues in childhood cancer survivors -- Medical and psychosocial issues in Hodgkin's disease survivors --Medical and psychosocial issues in testicular cancer survivors -- Medical and psychosocial issues in testicular cancer survivors -- Medical and psychosocial issues in gynecologic cancer survivors -- Medical, psychosocial, and health-related quality of life issues in breast cancer survivors -- Medical and psychosocial issues in prostate cancer survivors -- Physical and psychosocial issues in lung cancer survivors -- Cancer survivorship issues in colorectal cancer -- Medical and psychosocial issues in transplant survivors -- Second malignancies after radiation treatment and chemotherapy for primary cancers -- Psychosocial rehabilitation in cancer care -- Cancer advocacy.
  • Section I: Evaluation and management of musculoskeletal oncology problems -- Evaluation of bone tumors / Timothy A. Damron -- Evaluation of soft tissue tumors / Carol D. Morris -- Biopsy of musculoskeletal tumors / Edward A. Athanasian -- Treatment principles -- Surgical margins / Robert Quinn -- Benign tumors of bone / Cynthia M. Kelly -- Malignant bone lesions / Francis R. Patterson, Timoth A. Damron, and Carol D. Morris -- Soft tissue tumors / John Heiner and Jeremy White -- Pathologic fractures / Timothy A. Damron --Section II: Specific bone neoplasms and simulators -- Benign bone tumors -- Bone lesions / Felasfa M. Wodajo -- Cartilage lesions / Felasfa M. Wodajo -- Cystic lesions / Sung Wook Seo, Young Lae Moon, and Francis Young-In Lee -- Myogenic, lipogenic, and neural tumors / Sean V. McGarry and C. Parker Gibbs -- Fibrous lesions of bone / Sung Wook Seo, Young Lae Moon, and Francis Young-In Lee -- Giant cell tumor of bone / Sean V. McGarry and C. Parker Gibbs -- Vascular lesions / Sean V. McGarry and C. Parker Gibbs -- Other tumors of undefined neoplastic nature / Sean V. McGarry and C. Parker Gibbs -- Bone sarcomas -- Osteosarcoma / Francis R. Patterson -- Ewing sarcoma and primitive neuroectodermal tumor of bone / Bruce Rougraff -- Chondrosarcoma / R. Lor Randall and Kenneth J. Hunt -- Fibrous, fibrohistiocytic, and giant cell tumor malignancies / Hannah D. Morgan -- Notochordal tumors / Hannah D. Morgan -- Vascular sarcomas of bone / Hannah D. Morgan -- Myogenic, lipogenic, and epithelial bone sarcomas / Hannah D. Morgan -- Congenital and inherited bone conditions -- Familial adenomatous polyposis / Kathryn Palomino -- Beckwith-Wiedemann syndrome / Danielle A. Katz -- Skeletal dysplasias / Danielle A. Katz -- Retinoblastoma syndrome / Timothy A. Damron -- Rothmund-Thomson syndrome / Kathryn Palomino -- Werner syndrome / Kathryn Palomino -- Metastatic disease / Timothy A. Damron -- Hematologic malignancies / Valerae O. Lewis -- Metabolic bone diseases / Susan V. Bukata --Section III: Specific soft tissue neoplasms and simulators -- Benign soft tissue tumors / Timothy A. Damron and Gustavo de la Roza -- Soft tissue sarcomas / Carol D. Morris --Section IV: Basic science -- Cellular and molecular biology / Matthew J. Allen -- Growth and development of the musculoskeletal system / Donald E. Sweet and Thomas V. Smallman -- Genetic basis of musculoskeletal disorders / Sathappan S. Sathappan, Kirill Ilalov, and Paul E. Di Cesare -- Biomechanics / Frederick W. Werner and Joseph A. Spadaro -- Biomaterials / Joseph A. Spadaro, Michael T. Clarke, and Julie M. Hasenwinkel -- Principles of orthopaedic pharmacology / Carol D. Morris -- Bone form, function, injury, regeneration, and repair / Alexia Hernandez-Soria and Mathias Bostrom -- Articular cartilage structure, composition, and repair / Peter J. Roughley and Thomas V. Smallman -- Diarthrodial joints / Thomas V. Smallman, Kris Shekitka, and Donald Flemming -- Meniscal structure, function, repair, and replacement / Mark C. Drakos and Answorth A. Allen -- Intervertebral disk structure, composition, and mechanical function / Samuel A. Joseph, Jr., and Patrick Boland -- Tendon and ligament anatomy, biology, and biomechanics / Brian J. Harley and Joseph W. Bergman -- Peripheral nerve physiology, anatomy, and pathology / Shikha Sethi ... [et al.] -- Skeletal muscle anatomy, physiology, and mechanics / Bryan T. Kelly and William J. Robertson -- Infectious disorders of bone and joint / Thomas V. Smallman ... [et al.] -- Bacterial infection -- Granulomatous infection -- Infection associated with neuropathy -- Viral disorders -- Neoplasia / Matthew J. Allen.
  • 1. General Surgery -- Surgical Anatomy / Elisabeth Würinger -- Breast Cancer Surgery: Standard Principles / Florian Fitzal -- Oncoplastic Breast Surgery / Peter Schrenk -- 2. Oncoplastic Surgery (OPS) -- OPS and Breast Conserving Surgery (BSC) / Peter Schrenk, Elizabeth J. Hall-Findlay, Florian Fitzal, Andrea Grisotti and Donato Casella, et al. -- OPS and Mastectomy / Grant W. Carlson, Francesca De Lorenzi, Mario Rietjens, Andrea Manconi and Daniela Hoch, et al. -- Special Considerations / Florian Fitzal, Rupert Koller, Stefan Gärner, Elisabeth Grafinger-Witt and Mario Rietjens, et al.
  • Oncothermia 2011, Springer
  • Oral cancer metastasis 2010, Springer
  • Oral mucositis 2012, Springer
    Treatment tolerance is a challenge for most cancer patients, and it is therefore essential that healthcare professionals (HCP) are quick to recognize adverse events and implement management strategies to address them. This pocket book provides an in-depth guide to the epidemiology, diagnosis and management of oral mucositis, a common adverse event of chemotherapy.
  • Orbital tumors 2005, Springer
  • Origin of cancers 2010, Springer
  • Ovarian cancer 2008, Springer
  • Ovarian cancer. 2nd ed. 2009, Springer
  • "Today, we are exposed to an ever-growing number of chemicals in the environment and there is an increasing awareness of the effects of these chemicals on the ovaries. As such, the potential for xenobiotic-induced infertility needs to be better understood. Additionally, menopause-associated disorders are of growing health concern in view of the fact that by the year 2025, 19.5% of the population of the U.S. will be menopause-aged women. Exploring research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles, this book is an essential resource for researchers in academia, regulatory agencies, and industry"--Provided by publisher.
  • Oxidation 2008, Springer
  • P53 in the clinics 2013, Springer
    TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer /Pierre Hainaut --The Inheritance of p53 /Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson and Ying Cai, et al. --p53: Guardian of the Metabolome /Masha V. Poyurovsky and Carol Prives --The p53 Family and Stem Cell Biology /Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola and Gerry Melino, et al. --Mutant p53-Driven Tumorigenesis /Tamara Terzian and Guillermina Lozano --Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences /Monica Hollstein and Yang Xu --p53 Models for Mammary Carcinogenesis /Wolfgang Deppert and Genrich Tolstonog --TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers /Magali Olivier --Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer /Anita Langerød, Magali Olivier and Anne-Lise Børresen-Dale --TP53 Germline Mutations: Genetics of Li-Fraumeni Syndrome /Doua Bakry and David Malkin --Tp53 Gene Therapy for Cancer Treatment and Prevention /Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang and Zhaohui Peng, et al. --Upstream Targets in the p53 Pathway /Anna R. McCarthy and Sonia Lain --p53-Reactivating Molecules as Research Tools and Anticancer Drugs /Vera V. Grinkevich, Andreas Warnecke and Galina Selivanova --Targeting Mutant p53 for Improved Cancer Therapy /Jinfeng Shen, Vladimir J. N. Bykov and Klas G. Wiman --p53 Immunotherapy of Cancer /Hakim Echchannaoui and Matthias Theobald --Designing p53 Trials: A Surgical Oncologists View /Daniela Kandioler, Sonja Kappel and Brigitte Wolf --p53 in the Clinic: A Pathologist's View /Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet and Sylvie Lantuejoul, et al. --Genetic Counseling for TP53 Germline Mutations /Maria Isabel Waddington Achatz and Patricia Ashton-Prolla.
  • 1. Functional maturation of PAKs from unicellular to multicellular organisms / Masato Okada, Graham Cote, Ramesh K. Jha, and Hiroshi Maruta -- 2. Oncogenicity of PAKs and their substrates / Hong He and Hiroshi Maruta -- 3. Natural or synthetic therapeutics that block PAKs / Hiroshi Maruta, Shanta M. Messerli, and Ramesh K. Jha -- 4. PAK1-3 in infectious diseases / Hiroshi Maruta -- 5. PAK1 in brain diseases or disorders / Hiroshi Maruta and Shanta M. Messerli -- 6. PAK1 in Alzheimer's and Huntington's diseases / Qui-Lan Ma, Fusheng Yang, Sally A. Frautschy, and Greg M. Cole -- 7. PAK1 controls the lifespan / Sumino Yamase and Hiroshi Maruta -- 8. 3D structure and physiological regulation of PAKs / Stefan Knapp.
  • Pancreatic cancer 2008, Springer
  • Pancreatic cancer 2010, Springer
    v. 1. Chapters 1-25 -- v. 2. Chapters 26-54.
  • Pancreatic cancer 2005, Springer Protocols
  • The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, and analysis of tissue mineral fiber content. In addition, the medicolegal issues relating to asbestos-associated diseases are analyzed from the point of view of both the plaintiff and the defendant. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.
  • Epidemiology of Mesothelioma -- Molecular Biology -- Serosal Anatomy and Anatomic Distribution of Mesothelioma -- Clinical Aspects of Mesothelioma -- Management of Malignant Serosal Effusions -- Pathologic Diagnosis and Classification of Mesothelioma -- Macroscopic Features of Mesotheliomas -- Classification and Histologic Features of Mesotheliomas -- Differential Diagnosis: Mesothelial Proliferations -- Differential Diagnosis: Other Mesothelial Lesions -- Differential Diagnosis: Nonmesothelial Lesions -- Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas -- Differential Diagnosis: Other Nonmesothelial Tumors.
  • Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated withthe aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.
  • Patient Surveillance After Cancer Treatment covers the history of cancer patient surveillance after curative-intent treatment, the rationale, the methodologies used in the past and at present, the methodologies that will probably emerge in the future, the costs of surveillance, the definitions of various terms used in the field, and how those who are interested in the topic can get more information about it from the internet. The secondary focus of the book is to publicize the need for well-designed, adequately powered randomized clinical trials comparing two (or more) surveillance strategies for each type of cancer.The audience includes all oncologists, cancer researchers, medical economists and policy makers in government and insurance companies, and finally, interested patients.This book is part of the Current Clinical Oncology series, which provides cutting-edge knowledge of cancer diagnosis, management, and treatment. World renowned experts share their insights in all the major fields of clinical oncology. From the fundamentals of pathophysiology to the latest developments in experimental and novel therapies, Current Clinical Oncology is an indispensable resource for today's practicing oncologist.
  • Pediatric bone sarcomas 2009, Springer
  • v. 3 Springer
  • Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.
  • The pediatric head and neck cancer patient necessitates a multidisciplinary team of specialists to provide an optimal continuum of care. This A-Z guide provides practical, in-depth information for all medical professionals involved in the evaluation and treatment of these patients. Written in an easy to follow format, each entry contains illustrative figures to aid in pathological and radiographical diagnosis, as well as structured discussion of evaluation and multimodality management. The alphabetical layout eliminates redundancy and allows the busy physician to quickly locate relevant information. Pediatric Head and Neck Tumors is ideal for young physicians as well as attending physicians seeking to expand their knowledgebase to the various subspecialties involved in the multidisciplinary care of their patients.
  • Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.
  • Pediatric lymphomas 2007, Springer
    Introduction and historical background: pediatric Hodgkin lymphoma -- Biology and pathology of Hodgkin's disease -- Treatment of pediatric Hodgkin lymphoma -- Treatment of relapsed/refractory Hodgkin lymphoma -- Non-Hodgkin's lymphoma: introduction and historical background -- Biology and pathology of pediatric non-Hodgkin lymphoma -- B-cell lymphoma/ Burkitt lymphoma -- Anaplastic large-cell lymphoma -- Precursor B and precursor T-cell lymphoblastic lymphoma -- Cutaneous T-cell lymphomas and rare T-cell non-Hodgkin lymphomas -- Lymphoproliferative disorders related to immunodeficiencies -- Late effects following lymphoma treatment.
  • Pediatric neoplasia 2012, Springer
  • Pediatric oncology 2005, Springer
    Acute Leukemia / Michael E. Rytting, Mary S. Choroszy, Demetrios Petropoulos and Ka Wah Chan -- Hodgkin Lymphoma and Non-Hodgkin Lymphoma / Ka Wah Chan, Demetrios Petropoulos, Eric L. Chang and Michael E. Rytting -- Brain Tumors: Diagnosis, Surgery and Radiotherapy, and Supportive Care / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, Bartlett D. Moore and Donna R. Copeland -- Brain Tumors: Chemotherapy and Investigational Therapy / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor and Demetrios Petropoulos -- Wilms' Tumor / Norman Jaffe and Margaret G. Pearson -- Neuroblastoma / Joann L. Ater and Laura L. Worth -- Soft-Tissue Tumors / R. Beverly Raney, Richard J. Andrassy, Martin Blakely, Tina V. Fanning and Moshe H. Maor, et al. -- Osteosarcoma / Norman Jaffe and Margaret G. Pearson -- Ewing's Sarcoma / Cynthia E. Herzog, Anita Mahajan and Valerae O. Lewis -- Retinoblastoma / Misha Faustina, Cynthia E. Herzog and Dan S. Gombos -- Differentiated Thyroid Cancer / Rena Vassilopoulou-Sellin -- Medullary Thyroid Carcinoma / Robert F. Gagel -- Melanoma / Cynthia E. Herzog, Hafeez Diwan, Merrick I. Ross and Victor G. Prieto -- Novel Therapeutic Approaches / Sima S. Jeha and Laura L. Worth -- Supportive Care: Myelosuppression / Nidra I. Rodriguez Cruz, Renee M. Madden and Craig A. Mullen -- Supportive Care: Symptom Control / Renee M. Madden, Susannah E. Koontz-Webb, Donna S. Zhukovsky and Craig A. Mullen -- Behavioral Medicine in Cancer Care / Donna R. Copeland and Martha A. Askins -- The Adolescent and Young Adult Program / Sima S. Jeha and Martha A. Askins.
  • Pediatric oncology 2006, Springer
    General aspects of childhood leukemia -- Acute lymphoblastic leukemia -- Acute myelogenous leukemia -- Myelodysplastic syndrome -- Myeloproliferative syndromes (chronic myeloproliferative disorders) -- Non-Hodgkin lymphoma -- Hodgkin disease -- Histiocytoses -- Brain tumors -- Neuroblastoma -- Nephroblastoma (Wilms tumor) -- Soft tissue sarcoma -- Osteosarcoma -- Ewing sarcoma family of tumors -- Retinoblastoma -- Germ cell tumors -- Hepatic tumors -- Emergencies in pediatric oncology -- Oncological nursing care -- Psychology and psychosocial issues in children with cancer.
  • "Pediatric Radiation Oncology is the definitive text and reference on use of radiation therapy for childhood cancer. The fifth edition reviews all significant recent clinical trials--including, for the first time, significant European clinical trials--and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer"--Provided by publisher.
  • Overview of childhood cancer : incidence, survival, and late effects -- Challenges of treating children with radiation therapy -- Leukemia -- Tumors of the central nervous system -- Hodgkin lymphoma -- Neuroblastoma -- Wilms' tumor -- Soft-tissue tumors : (rhabdomyosarcoma and other soft-tissue sarcomas) -- Bone sarcomas (osteosarcoma and Ewing's sarcoma) -- Retinoblastoma.
  • Penile cancer 2013, Springer
    Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer. The book also addresses many of the novel diagnostic and therapeutic surgical appro
  • "Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book's comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with acompletely revamped digital experience, powered by Inkling! NEW to the Sixth Edition ... site-specific chapters include relevant background information on each tumor including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more. Over 1,400 full-color illustrationshighlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy. Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy. Greater emphasis on palliative and supportive carereflects the role of radiation treatment in non-curative roles. New editors and contributors let you benefit from their decades of experience. Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more."

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