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  • Diagnosis and staging -- Primary treatment -- Communication within the context of multidisciplinary care -- Explaining follow-up -- Progression and terminal -- Explaining research -- Complementary and alternative medicines and integrative oncology.
  • Complementary & Alternative Medicine for Prostate and Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This is a critical distinction between this book and any other Complementary & Alternative Medicine (CAM) books published to date. Each section of the book provides an easy to reference guide into the topic of interest for the individual that works in urology. The various sub-specialty groups in urology are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether it is fertility, bladder cancer, or prostate disease. Rather than having to sort through the now thousands of articles published yearly on CAM in medicine, this volume focuses first on the specialty and secondarily how it compares to the overall CAM literature. Each chapter includes a summary page that will allow the physician a rapid review of the subject with a patient, colleague or student.
  • Complex general surgical oncology. Volume 1-2 v. 1-2, 2013-14., Future Med
    v. 2 Future Med
    Volume 1. Breast cancer -- High-risk breast lesions / Vance Sohn -- Surgical management of ductal carcinoma in situ / Rosalinda Alvarado -- Regional lymph node metastases in breast cancer / Sarah DeSnyder -- Neoadjuvant/adjuvant therapy for breast cancer / Sarah DeSnyder -- Nonductal malignancies / Sarah DeSnyder -- Management of high-risk breast cancer syndromes / Rosalinda Alvarado -- Reconstruction following breast surgery / Steve Lee & Daniel E. Abbott -- Endocrine malignancies -- Well-differentiated thyroid cancer / Steve Lee & Daniel E. Abbott -- Multiple endocrine neoplasia / Paxton Dickson -- Adrenal pathology and approaches to resection / Daniel E. Abbott -- Melanoma -- Margins in melanoma / Genevieve Boland -- Sentinel lymph node biopsy in melanoma / Genevieve Boland -- In-transit disease and regional therapy / Vance Sohn -- Soft-tissue sarcoma -- Retroperitoneal sarcoma / Alex Haynes -- Adjuvant/neoadjuvant therapy for sarcoma / Christina L. Roland -- Esophageal cancer -- EMR, RFA and argon plasma coagulation for treatment of Barrett's esophagus and early adenocarcinoma / Amanda Cooper -- Distal esophageal tumors / Maria C. Russell -- Squamous cell versus adenocarcinoma of the esophagus / Christina L. Roland -- Index.Volume 2. Gastric cancer -- Gastric adenocarcinoma / Maria Citarella Russell -- Small bowel cancer -- Small bowel neoplasms / Paxton Dickson -- Colorectal cancer -- Management of rectal cancer / Genevieve Boland -- Hereditary colorectal cancer syndromes / Christina Bailey -- Reconstruction after low rectal resections and pelvic exenteration / Amanda Cooper -- Hepatobiliary cancer -- Cholangiocarcinoma / Daniel E. Abbott -- Hepatic metastases / Genevieve Boland -- Resection and ablation techniques for hepatic lesions / Steve Lee & Daniel E. Abbott -- Resection versus transplantation for hepatocellular carcinoma / Christina L. Roland -- Pancreatic cancer -- Pancreatic cystic neoplasms / Robert E. Roses -- Pancreatic adenocarcinoma / Daniel E. Abbott -- Neuroendocrine tumors of the pancreas / Alex Haynes -- Conditions affecting the pancreaticobiliary system / Vance Sohn -- Peritoneal malignancy -- Peritoneal mesothelioma / Vance Sohn -- Index.
  • Computational biology 2009, Springer
    Identification of Relevant Genes from Microarray Experiments based on Partial Least Squares Weights: Application to Cancer Genomics -- Geometric Biclustering and Its Applications to Cancer Tissue Classification Based on DNA Microarray Gene Expression Data -- Statistical Analysis on Microarray Data: Selection of Gene Prognosis Signatures -- Agent-Based Modeling of Ductal Carcinoma In Situ: Application to Patient-Specific Breast Cancer Modeling -- Multicluster Class-Based Classification for the Diagnosis of Suspicious Areas in Digital Mammograms -- Analysis of Cancer Data Using Evolutionary Computation -- Analysis of Population-Based Genetic Association Studies Applied to Cancer Susceptibility and Prognosis -- Selected Applications of Graph-Based Tracking Methods for Cancer Research -- Recent Advances in Cell Classification for Cancer Research and Drug Discovery -- Computational Tools and Resources for Systems Biology Approaches in Cancer -- Laser Speckle Imaging for Blood Flow Analysis -- The Challenges in Blood Proteomic Biomarker Discovery.
  • Contemporary IMRT 2005, CRCnetBASE
  • Content-based image retrieval (CBIR) is the process of retrieval of images from a database that are similar to a query image, using measures derived from the images themselves, rather than relying on accompanying text or annotation. To achieve CBIR, the contents of the images need to be characterized by quantitative features; the features of the query image are compared with the features of each image in the database and images having high similarity with respect to the query image are retrieved and displayed. CBIR of medical images is a useful tool and could provide radiologists with assistance in the form of a display of relevant past cases. One of the challenging aspects of CBIR is to extract features from the images to represent their visual, diagnostic, or application-specific information content. In this book, methods are presented for preprocessing, segmentation, landmarking, feature extraction, and indexing of mammograms for CBIR. The preprocessing steps include anisotropic diffusion and the Wiener filter to remove noise and perform image enhancement. Techniques are described for segmentation of the breast and fibroglandular disk, including maximum entropy, a moment-preserving method, and Otsu's method. Image processing techniques are described for automatic detection of the nipple and the edge of the pectoral muscle via analysis in the Radon domain. By using the nipple and the pectoral muscle as landmarks, mammograms are divided into their internal, external, upper, and lower parts for further analysis. Methods are presented for feature extraction using texture analysis, shape analysis, granulometric analysis, moments, and statistical measures.
  • Gynecological cancers are some of the most commonly occurring malignancies in women. Despite their high incidence, treatment and management of these cancers remain controversial, with conflicting evidence about many aspects of the disease. Controversies in the Management of Gynecological Cancers offers a unique assessment of the opposing sides of the controversial issues associated with gynecological cancers, and aims to provide professionals in the field with a keener sense of the underlying evidence-base and a starting point from which to follow the ongoing debate. A section on the direction of future research to resolve these issues completes the discussion in each chapter. This book will appeal to specialists, trainees and healthcare workers in gynecological oncology, gynecologists, medical oncologists and radiation oncologists, and is an excellent starting point for anyone who wishes to gain a better understanding of the complex nature of the management of gynecological malignancy.
  • Prognostic factors in histopathology of lung cancer / A. Fisseler-Eckhoff -- FDG-PET/CT in lung cancer : an update / R.-P. Baum, C. Świętaszczyk, V. Prasad -- Whole-body magnetic resonance imaging for staging of lung cancer / R. Puls ... [et al.] -- Bronchoscopy/endobronchial ultrasound / F.J.F. Herth -- New developments in videomediastinoscopy : video-assisted mediastinoscopic lymphadenectomy and mediastinoscopic ultrasound / B. Witte -- Resection in stage I/II non-small cell lung cancer / F.M. Smolle-Juettner ... [et al.] -- Role of mediastinal lymph node dissection in non-small cell lung cancer / S. Bölükbas, M.H. Eberlein, J. Schirren -- Radiation therapy for early stage (I/II) non-small cell lung cancer / B. Jeremic ... [et al.] -- Stereotactic body radiation therapy for early non-small cell lung cancer / F. Zimmermann ... [et al.] -- Extended surgical resection in stage III non-small cell lung cancer / S. Hillinger, W. Weder -- Stage III : definitive chemoradiotherapy / R. Fietkau, S. Semrau -- Adjuvant therapy in early-stage non-small cell lung cancer / M. Serke -- Postoperative irradiation in non-small cell lung cancer / S. Höcht ... [et al.] -- Altered fractionation schemes in radiotherapy / M. Stuschke, C. Pöttgen -- Chemotherapy of advanced non-small cell lung cancer / R. Pirker, W. Minar -- Radiotherapy / I.A. Adamietz -- Treatment of limited disease small cell lung cancer / D. de Ruysscher -- Radiochemotherapy in extensive disease small cell lung cancer ED-SCLC / B. Jeremic ... [et al.] -- Radiotherapy for extensive stage small cell lung cancer / B.J. Slotman -- Controversies in the treatment of advanced stages of small cell lung cancer / A. Schmittel -- Complementary and alternative medicine in lung cancer patients : a neglected phenomenon? / O. Micke.
  • Prostate cancer and active surveillance / Abrahamsson, P.A. -- Radical Prostatectomy in the 21th Century: the gold standard for localized and locally advanced prostate cancer / Schostak, M.; Miller, K.; Schrader, M. -- Radiotherapy as primary treatment modality / Sia, M.; Rosewall, T.; Warde, P. -- Combined radiotherapy and hormonal therapy in the treatment of prostate cancer / Boehmer, D. -- Postoperative adjuvant radiotherapy: standard of care? / Bottke, D.; Wiegel, T. -- Adjuvant hormonal treatment: the bicalutamide early prostate cancer program / Wirth, M.P.; Hakenberg, O.W.; Froehner, M. -- Hormone therapy for prostate cancer: immediate initiation / Schostak, M.; Miller, K.; Schrader, M. -- Lymphadenectomy in prostate cancer: radioguided lymph node mapping: an adequate staging method / Winter, A.; Wawroschek, F. -- Radiotherapy in lymph-node positive prostate cancer patients: potentially curable?: single institutional experience regarding outcome and side effects / Goldner, G.; Pötter, R. -- Radiotherapy in biochemical recurrences after surgery for prostate cancer / Hocht, S. ... [et al.] -- Recurrence following radiotherapy / Desgrandchamps, F. -- Secondary hormonal manipulation / Merseburger, A.S. ... [et al.] -- Chemotherapy in hormone-refractory prostate cancer / Wolff, J.M. -- A randomized phase II trial comparing weekly taxotere + prednisone (P) versus prednisone alone in androgen-independent prostate cancer / Fossa, S.D. -- Hormone-refractory and metastatic prostate cancer: palliative radiotherapy / Moser, L.; Schubert, T.; Hinkelbein, W.
  • Cutaneous lymphomas - radiotherapeutic strategies / Wilson, L.D., Jones, G.W., Smith, B.D. -- The clinical impact of T cell receptor rearrangement analysis in cutaneous T cell lymphoma / Assaf, C. -- Classification of primary cutaneous lymphomas / Assaf, C. ... [et al.] -- Basal cell and squamous cell carcinoma - radiotherapeutic approaches / Panizzon, R.G. -- Kaposi's sarcoma - radiotherapeutic aspects / Niewald, M.; Räbe, C. -- Pathogenesis and clinical manifestation of Kaposi's sarcoma / Geilen, C.C., Husak, R., Steinhoff, M. -- Merkel cell carcinoma - clinical presentation and treatment / Moll, I. -- Merkel cell carcinoma - uncommon and aggressive cutaneous tumour / Greiner, R.H. ... [et al.] -- Potential of radiation therapy in the multimodal management of Merkel cell carcinoma / Becker, G., Bottke, D. --Skin and other reactions to radiotherapy - clinical presentation and radiobiology of skin reactions / Dörr, W. -- Management of skin and related reactions to radiotherapy / Seegenschmiedt, H. -- Malignant melanoma - markers for progression and prognosis in malignant melanoma / Geilen, C.C. ... [et al.] -- Malignant melanoma - sentinel lymph node biopsy and surgical procedures / Kaufmann, R. -- The role of radiotherapy in malignant melanoma / Marnitz, S., Hoecht, S., Hinkelbein, W. -- Malignant melanoma: classification and staging of malignant melanoma / Eigentler, T.K., Garbe, C. -- Malignant melanoma: PET/CT as a staging procedure / Müller, S.P. -- Malignant melanoma - clinical development of peptide-based melanoma vaccines / Schmittel, A. ... [et al.].
  • Current and emerging therapeutics for multiple myeloma / Noopur Raje & Sundar Jagannath -- Current standard treatment of myeloma / Ray Powles & Arif Meghani -- Stem cell transplantation / Hermann Einsele -- New immune modulators / Loredana Santo & Noopur Raje -- Histone deacetylase inhibitors / Maurizio Zangari, Tamara Berno & Fenghuang Zhan -- Targeted treatment of multiple myeloma : proteasome inhibitors / Kristen M. Sanfilippo & Ravi Vij -- AKT inhibitors in multiple myeloma / R. Donald Harvey & Sagar Lonial -- Future directions / Klaus Podar -- Index.
  • "Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward."
  • Development of a conditional mouse model for head and neck squamous cell carcinoma / Bindels, E.M.J., van de Brekel, M.W.M. -- Hypofolatemia as a risk factor for head and neck cancer / Almadori, G. ... [et al.] -- Reduced DNA repair capacity in laryngeal cancer subjects: a comparison of phenotypic and genotypic results / Gajacka, M. ... [et al.] -- Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization / Götte, K. ... [et al.] -- Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck / Thurfjell, N. ... [et al.] -- p53, p63 and p73 expression in squamous cell carcinomas of the head and neck and their response to cisplatin exposure / Balz, V. ... [et al.] --Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival / Wittekindt, C. ... [et al.] -- EGFR-antibody-supplemented TPF chemotherapy: preclinical investigations to a novel approach for head and neck cancer induction treatment / Knecht, R. ... [et al.] -- Nuclear factor kappa B as a common target and activator of oncogenes in head and neck squamous cell carcinoma / Chang, A.A., Van Waes, C. -- Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy / Riedel, F. ... [et al.] -- Expression pattern of chemokine receptors 6 and 7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype / Wang, J. ... [et al.] -- p53-based immunotherapy of cancer / De Leo, A.B. --p53 as an immunotherapeutic target in head and neck cancer: approaches to reversing unresponsiveness of T lymphocytes and preventing tumor escape / Hoffmann, T.K. ... [et al.] -- Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease / Kuss, I. ... [et al.] -- Antitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccine / Herold-Mende, C. ... [et al.] -- Prognostic factors: confusion caused by bad quality of design, analysis and reporting of many studies / Sauerbrei, W.
  • Cutaneous lymphomas v. 2, 2006., Springer
    v. 2 Unusual cases.
  • The Peripheral Nerve and Cutaneous Neural Tumors: Introduction, Definitions, and Classification -- Special Techniques for the Study of Cutaneous Neural Tumors -- Nonneoplastic and Hamartomatous Lesions of the Cutaneous Peripheral Nerve -- Benign Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Malignant Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Cutaneous Proliferations with Putative Neural Differentiation -- Cutaneous Neuroblastic and Ganglion Cell Proliferations -- Cutaneous Glial and Meningothelial Proliferations -- Appendix: Practical Approach to Neural Tumors? Flowcharts and Differential Diagnostic Table.
  • Cytokines and cancer 2005, Springer
  • Helicobacter pylori and cytokines in the genesis of gastric cancer / Richard M. Peek, Jr. -- HTLV-1, cytokines, and cancer / Michael Lairmore and Lee Ratner -- Herpesviruses, cytokines, and cancer / Frank J. Jenkins and Heather R. Hensler -- Tumor necrosis factor and cancer / Mark DeWitte ... [et al.] -- Transforming growth factor-[beta] and cancer / Alyssa R. Bonine-Summers, Brian K. Law, and Harold L. Moses -- Interleukin-1 family of cytokines and cancer / Michael T. Lotze--Interleukin-4/13 and cancer / Koji Kawakami and Raj K. Puri -- Interleukin-6 and Castleman's disease / Norihiro Nishimoto -- Interleukin-10 (IL-10): biology, immune, regulation, and cancer / Shin-ichiro Fujii and Michael T. Lotze -- Cytokines in multiple myeloma: therapeutic implications / Dharminder Chauhan, Teru Hideshima, and Kenneth C. Anderson -- In vivo murine cytokine models and the genesis of cancer / Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri --Experimental models of cytokines and cancer prevention / Mark J. Smyth ... [et al.] -- Cytokines in the tumor stroma / Michael C. Ostrowski -- Cytokines and tumor angiogenesis / Sharmila Roy-Chowdhury and Charles K. Brown -- Chemokine and receptor expression in tumor progression / Paola Allavena, Federica Marchesi, and Alberto Mantovani -- The biology of cancer cachexia and the role of TNF-[alpha] / Denis C. Guttridge -- Interleukin-2 and cancer therapy / Kim Margolin and Joseph Clark -- Interleukin-12 and cancer therapy / Timothy E. Bael and Jared Gollob -- The type I interferon system with emphasis on its role in malignancies: interferons are more than "antivirals" / Stergios J. Moschos ... [et al.] -- Combination cytokine therapy / Seth M. Cohen and Howard L. Kaufman -- Novel strategies for cytokine administration via targetting / Paul M. Sondel ... [et al.] -- Cytokines and cancer vaccines / Hideho Okada and Michael T. Lotze -- Anticytokine therapy / Miguel A. Villalona-Calero -- Cytokines in the supportive care of cancer / John A. Glaspy.
  • Normal histology of female genital organs -- Lesions of the vulva and vagina -- Squamous lesions of the cervix -- Glandular lesions of the cervix -- Human papillomavirus for cervical pathology -- Endometrial epithelial neoplasms -- Nonepithelial tumors of uterine corpus -- Gestational trophoblastic disease -- Tumors of fallopian tube and broad ligament -- Epithelial neoplasms of ovary -- Nonepithelial tumor of ovary -- Tumors of peritoneum.
  • In recent decades, cytopathology has assumed an increasing role in the primary diagnosis of mass lesions owing to its ability to provide rapid, non-invasive, and timely information. With cytopathology at the forefront of diagnosis and prognostication of neoplastic lesions, it is essential that physicians involved in the diagnosis and treatment of precancerous lesions and cancer have a clear understanding of specimen collection techniques, terminology for reporting, and outcomes in various diagnostic categories. This book provides a comprehensive overview of the role of cytology at various body sites. The diagnostic details covered are abbreviated in comparison with those in pathology texts. Instead, a more clinical approach is taken, with the focus on the advantages and limitations of techniques and the key features of entities that are important to clinicians. Pathological clinical correlation is highlighted throughout the book, ensuring that it will be highly relevant for clinicians. In particular, physicians who deal with oncology patients will find it to be a rich source of guidance on how to use and understand cytopathology in the diagnosis and exclusion of malignancy.
  • & Quot;Soft Tissue Cytopathology" by Anil V. Parwani, MD, PhD and Walid E. Khalbuss, MD, PhD, will fulfill the need for an easy-to-use and authoritative synopsis of soft tissue cytopathology. This volume, part of "The Essentials in Cytopathology book series," fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Anil V. Parwani, MD, PhD, is Associate Professor of Pathology at the University of Pittsburgh Medical Center - S.
  • Cytopathological techniques for the diagnosis of glandular lesions of the genital tract -- Bethesda System Classification of glandular lesions on cervical cytology -- Cytopathology of the benign glandular lesions of the cervix and glandular cytopathology of the vagina -- Cytopathology of adenocarcinoma in situ of the endocervix and its differential diagnosis -- Cytopathology of the malignant invasive lesions of the endocervix -- Endometrial hyperplasias -- Endometrial adenocarcinoma : current status and future of prevention and early diagnosis -- Cytopathology of ovarian lesions : the intraoperative approach -- Glandular lesions of the vulva -- Glandular lesions of the fallopian tube -- Metastatic glandular lesions -- Ancillary techniques for the diagnosis of glandular lesions of the female genital tract
  • The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] -- FasL expression and reverse signaling / M. Lettau ... [et al.] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier.
  • v. 2, 2011 Springer
  • A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.
  • Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.
  • The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin --Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • Dermal tumors 2011, Springer
    An Overview of Cutaneous Lymphomas -- Vascular Tumors -- Histiocytic Proliferations -- ʺFibrohistiocyticʺ Proliferations -- Tumors of Fat, Nerve, and Smooth Muscle -- Cutaneous Metastases -- Further Reading.
  • Dermatopathology 2013, Springer
    Elements of Cutaneous Embryology, Anatomy, and Biochemistry -- Classification of Cutaneous Lesions -- Hereditary Lesions -- Malformative Lesions -- Inflammatory Cutaneous Lesions -- Proliferative Cutaneous Lesions -- Miscellaneous Cutaneous Lesions.
  • Desmoid tumors 2011, Springer
    Clinical Presentation of Desmoid Tumors -- Pathology of Desmoid Tumors -- APC/β-Catenin Deregulation in Desmoid Tumors: Important Implications for Diagnosis, Prognosis, and Therapy -- Imaging Techniques in Desmoid Tumors -- Surgical Management of Desmoid Tumors -- Systemic Therapy in the Treatment of Desmoid Tumors -- Radiation Therapy for Desmoid Tumors -- Interventional Radiology -- Introduction -- Desmoid Disease in Familial Adenomatous Polyposis -- Desmoid Tumor in Children and Adolescents: The Influence of Age -- Microarrays and High-Throughput Sequencing in Desmoid-Type Fibromatosis and Scar -- Desmoid Tumors: Are They Benign or Malignant? -- The Role of Patient Advocacy Groups in Rare Tumors Such as Desmoid Tumors.
  • The hedgehog signaling pathway in cancer / J. Vestergaard, Mads Bak, L.A. Larsen -- Rho GTPases and cancer / P. Buongiorno, B. Bapat -- Developmental biology of fibroblasts and neoplastic disease / D. Brouty-Boyé -- The extracellular matrix during normal development and neoplastic growth / J. Labat-Robert, L. Robert -- Wilms' tumor : starting off the kidney all over again? / M. Little -- Testicular teratomas : back to pluripotent stem cells / T. Kimura ... [et al.] / Tumor suppressors APC and VHL : gatekeepers of the intestine and kidney / R.H. Giles, E.E. Voest -- Hormonal and stromal regulation of normal and neoplastic prostatic growth / W.A. Ricke ... [et al.] -- Neoplastic growth through the developmental stages of the organism / A. Maciera-Coelho.
  • The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging --Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas --Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.
  • Diabetes and cancer 2008, Karger
  • Morphologic Patterns -- Common Diagnostic Discrepancies -- Frozen Section of Ovarian Lesions -- Surface Epithelial Tumors: Pathology Introduction -- Surface Epithelial Tumors: Clinical Introduction -- Pathology of Serous Tumors -- Pathology of Endometrioid Tumors -- Pathology of Clear Cell Tumors -- Pathology of Mucinous Tumors -- Uncommon Epithelial Ovarian Tumors -- Metastatic Tumors -- Germ Cell and Sex Cord Stromal Tumors: Clinical Introduction -- Pathology of Germ Cell Tumors -- Sex Cord Stromal Tumors of the Ovary -- Pathology of Mesenchymal and Hematopoietic Tumors -- Tumors of Uncertain Histogenesis -- Fallopian Tube and Peritoneum -- Familial Cancer and Prophylactic Surgery -- Peritoneal Cytology.
  • Diagnostic Imaging of Lung and Pleural Tumors -- The Staging of Lung Cancer -- Non-Small Cell Carcinomas -- Neuroendocrine Carcinomas -- Biphasic Tumors of the Lungs -- Salivary Gland and Adnexal Type Tumors of the Lungs -- Tumors Derived from Presumed Ectopic Tissues -- Vascular Tumors of the Lungs -- Mesenchymal Tumors of the Lungs -- Lung Tumors of Uncertain Histogenesis -- Malignant Lymphomas Involving Lung and Pleura -- Tumors of the Pleura -- Tumor-like Conditions and Benign Tumors of the Lung -- Molecular Pathology of Lung Cancer.
  • 1. Gene Signatures and Soft Tissue Sarcomas: Status of Art and Perspectives / Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini -- 2. Heterogeneity of Breast Cancer: Gene Signatures and Beyond / Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens -- 3. Gene Signatures in CRC and Liver Metastasis / Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo -- 4. Gene Signatures in Gastrointestinal Stromal Tumors / Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybył, and Maria Debiec-Rychter -- 5. Pancreatic Cancer Genetics / Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti -- 6. Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer / Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei -- 7. Gene Signatures in Gastric Cancer / Laura Ottini, Mario Falchetti, and Gabriella Nesi -- 8. Gene Signatures in Colorectal Cancer / Alessandro Lugli and Inti Zlobec -- 9. The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays / Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia -- 10. Primary Epithelial Ovarian Neoplasms: New Concepts Concerning Origin, Pathogenesis and Classification Based on Morphology, Immunomarkers, Molecular Features, and Gene Expression Studies / Bernard Czernobilsky, Leonor Leider-Trejo, Daniele Fanale, and Antonio Russo -- 11. Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns / Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone.
  • Diet and cancer v. 1-, 2010-, Springer
  • Radiologic and pathologic approach to bone tumors -- Bone-forming (osteogenic) lesions -- Cartilage (chondrogenic) lesions -- Fibrogenic, fibroosseous, and fibrohistiocytic lesions -- Round cell lesions -- Vascular lesions -- Miscellaneous tumors and tumor-like lesions -- Metastases -- Tumors and tumor-like lesions of the joints.
  • The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life. Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualized therapy for this kind of tumor. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book. This book uniquely focuses on addressing diffuse low-grade gliomas in adults and is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
  • Breast anatomy and development -- Molecular mechanisms regulating breast development -- Stem cells in breast development and carcinogenesis: concepts and clinical perspectives -- Physical examination of the breast -- Management of the palpable breast mass -- Management of disorders of the ductal system and infections -- Management of breast pain -- Abnormalities of the breast in pregnancy and lactation -- Management of gynecomastia -- Pathology of benign breast disorders -- Screening for breast cancer -- Imaging analysis: mammography -- Breast ultrasound -- Imaging analysis: magnetic resonance imaging -- Imaging: new techniques -- Image-guided biopsy of nonpalpable breast lesions -- Management summary on breast imaging -- Inherited genetic factors and breast cancer -- Genetic testing and management of patients with hereditary breast cancer -- Nongenetic factors in the causation of breast cancer -- Management of other high risk patients -- Chemoprevention: clinical aspects -- Pathology and biological features of premalignant breast disease -- Lobular carcinoma in situ: biology and pathology -- Lobular carcinoma in situ: clinical management -- Ductal carcinoma in situ and microinvasive carcinoma -- Breast cancer genomics -- Pathology of invasive breast cancer -- Clinical aspects of estrogen and progesterone receptors -- ERBB2 testing: assessment of status for targeted therapies -- Prognostic and predictive markers -- Gene arrays, prognosis, and therapeutic interventions -- Bone marrow micrometastases and circulating tumor cells -- Evaluation of patients for metastasis prior to primary therapy -- Staging of breast cancer -- Mastectomy -- Breast-conserving therapy: conventional whole breast irradiation -- Breast-conserving therapy: accelerated partial breast irradiation -- Breast reconstruction -- Local therapy for the breast and chest wall -- Sentinel lymph node dissection -- Axillary dissection -- Axillary irradiation -- Preserving and restoring function after local treatment -- Lymphedema -- Treatment of the axilla and other regional nodes -- Postmastectomy radiation therapy -- Adjuvant systemic therapy: endocrine therapy -- Adjuvant systemic therapy: chemotherapy --Adjuvant systemic therapy: chemoendocrine -- Adjuvant treatment of ERBB2 positive breast cancer -- Adjuvant systemic therapy: bisphosphonates -- Lifestyle issues in breast cancer survivors -- Management of menopausal symptoms in breast cancer survivors -- Side effects of systemic therapy: neurocognitive, cardiac, and secondary malignancies -- Pharmacogenomics of systemic therapy of breast cancer -- Guidelines for adjuvant systemic therapy -- Preoperative therapy for operable breast cancer -- Preoperative endocrine therapy for operable breast cancer -- Local-regional therapy considerations in patients receiving preoperative chemotherapy -- Locally advanced breast cancer -- Inflammatory breast cancer -- Management summary on preoperative systemic therapy -- Male breast cancer -- Phyllodes tumors -- Paget's disease -- Nonepithelial malignancies of the breast -- Breast cancer during pregnancy and subsequent pregnancy in breast cancer survivors -- Occult primary cancer with axillary metastases -- Surveillance of patients following primary therapy -- Surgery for the primary in patients with distant metastases -- Local-regional recurrence after breast-conservation treatment or mastectomy -- Treatment of metastatic breast cancer: endocrine therapy -- Treatment of metastatic breast cancer: chemotherapy -- Treatment of HER2-overexpressing metastatic breast cancer -- End-of-life considerations in patients with breast cancer -- Management summary for metastatic disease for the care of patients with metastatic disease -- Angiogenesis inhibition in breast cancer -- Tyrosine kinase inhibitors -- Newer targeted therapy in breast cancer -- Brain metastases -- Epidural metastases -- Leptomeningeal metastasis -- Brachial plexopathy in patients with breast cancer -- Ocular metastases -- Malignant effusions -- Management of discrete pulmonary nodules -- Management of lsolated liver metastases -- Bone-directed therapy and breast cancer: bisphosphonates, monoclonal anitbody, and radionuclides -- Local management of bone metastases -- Breast cancer in older women -- Breast cancer in younger women -- Breast cancer in minority women -- Nursing care in patient management and quality of life -- Psychosocial adaptation during and after breast cancer -- Reproductive issues in breast cancer survivors -- Medical legal aspects of breast cancer evaluation -- Cost and cost-effectiveness considerations.
  • The HIF-2[alpha]-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization / A. Pietras, A.S. Johnsson and S. Pahlman -- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance / Z. Li and J.N. Rich -- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression / A.J. Giaccia and E. Schipani -- The role of hypoxia regulated microRNAs in cancer / R. McCormick ... [et al.] -- Oxygen sensing: A common crossroad in cancer and neurodegeneration / A. Quaegebeur and P. Carmeliet -- Hypoxia-inducible factors as essential regulators of inflammation / H.Z. Imtiyaz and M.C. Simon -- Hypoxia and metastasis in breast cancer / H. Rundqvist and R.S. Johnson.
  • Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
  • DNA and RNA nanobiotechnologies have currently reached the status of one of the most dynamic research areas in the field of drug delivery in molecular medicine. Scientists and bio-engineers are creating totally new nanometer-scale structures with unique biological properties for a wide range of medical applications. The book, written by world-leading scientists in this new field, gives an overview of various aspects and applications of DNA and RNA nanotechnologies. These include the design and synthesis of DNA and RNA nanostructures with the aim of using them for different kinds of drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, siRNA delivery for cancer treatment, and even analytical and therapeutic applications of aptamer-based nanoparticles. This volume will be of interest not only to graduate students and researchers in the field of molecular medicine and molecular biology, but also to chemists interested in the biological fields. As a matter of fact, the book contains so many new and unique approaches to this area of molecular medicine that it may inspire the interested reader to undertake research into nucleic acid nanotechnologies.
  • DNA damage response 2009, Springer
    DNA Damage Sensing and Signaling / Daniel Durocher -- Signaling at Stalled Replication Forks / Daniel A. Mordes and David Cortez -- An Oncogene-Induced DNA Replication Stress Model for Cancer Development / Thanos D. Halazonetis -- Cellular Responses to Oxidative Stress / Inbal Dar and Ari Barzilai -- Cell Cycle Regulation and DNA Damage / Ryo Sakasai and Randal S. Tibbetts -- Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks / Julia Pagan, Emma Bolderson, Mathew Jones and Kum Kum Khanna -- Telomere Metabolism and DNA Damage Response / Tej K. Pandita -- DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential / Laura M. Williamson, Chris T. Williamson and Susan P. Lees-Miller -- DNA Base Excision Repair: A Recipe for Survival / Rabindra Roy and Sankar Mitra -- DNA Damage Tolerance and Translesion Synthesis / Alan R. Lehmann -- Nucleotide Excision Repair: from DNA Damage Processing to Human Disease / Mischa G. Vrouwe and Leon H.F. Mullenders -- Chromosomal Single-Strand Break Repair / Keith W. Caldecott -- Mouse Models of DNA Double Strand Break Repair Deficiency and Cancer / Sachin Katyal and Peter J. McKinnon -- Cancer Biomarkers Associated with Damage Response Genes / Anne E. Kiltie, Marie Fernet and Janet Hall -- Linking Human RecQ Helicases to DNA Damage Response and Aging / Wen-Hsing Cheng, Byungchan Ahn and Vilhelm A. Bohr -- Single-Stranded DNA Binding Proteins Involved in Genome Maintenance / Derek J. Richard and Kum Kum Khanna -- The Fanconi anemia-BRCA Pathway and Cancer / Toshiyasu Taniguchi -- BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment / Kienan Savage and D. Paul Harkin.
  • DNA methylation : three decades in search of function / Aharon Razin -- Epigenetic mechanisms of gene regulation : relationships between DNA methylation, histone modification, and chromatin structure / Keith D. Robertson -- DNA hypo- vs. hypermethylation in cancer : tumor specificity, tumor progression, and therapeutic implications / Melanie Ehrlich and Guanchao Jiang -- DNA methylation in urological cancers / Wolfgang A. Schulz and Hans-Helge Seifert -- DNA methylation in colorectal cancer / Jeremy R. Jass ... [et al.] -- CpG island hypermethylation of tumor suppressor genes in human cancer : concepts, methodologies and uses / Michel Herranz and Manel Esteller -- The loss of methyl groups in DNA of tumor cells and tissues : the immunochemical approach / Alain Niveleau ... [et al.] -- Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays / Susan H. Wei ... [et al.] -- Methylation analysis in cancer : (epi)genomic fast track from discovery to clinical routine / Carolina Haefliger, Sabine Maier and Alexander Olek --Regulation of DNA methyltransferases in cancer / Nancy Detich and Moshe Szyf -- Inhibition of poly(ADP-ribosyl)ation allows DNA hypermethylation / Anna Reale ... [et al.] -- The role of active demethylation in cancer and its therapeutic potential / Moshe Szyf ... [et al.] -- Purine analogues and their role in methylation and cancer chemotherapy / Katherine L. Seley and Sylvester L. Mosley -- DNA methyltransferase inhibitors : paving the way for epigenetic cancer therapeutics / Gregory K. Reid and A. Robert MacLeod -- Preclinical and clinical studies on 5-aza-2'-deoxycytidine, a potent inhibitor of DNA methylation, in cancer therapy / Richard L. Momparler -- Anticancer gene therapy by in vivo DNA electrotransfer of MBD2 antisense / Pascal Bigey and Daniel Scherman.
  • Regulation of chromatin and DNA-methylation patterns in blood cell development / C. Bonifer, P. Lefevre, and H. Tagoh -- Methylation dynamics in the early mammalian embryo : implications of genome reprogramming defects for development / T. Haaf -- Epigenetic regulation in drosophila / F. Lyko ... [et.al.] -- Epimutations in human disease / B. Horsthemke -- Epigenotypes of latent herpesvirus genomes / J. Minarovits -- Epigenetics of complex diseases : from general theory to laboratory experiments / A. Schumacher and A. Petronis -- MSL proteins and the regulation of gene expression / S. Rea and A. Akhtar -- DNA methylation profiles of female steroid hormone-driven human malignancies / M. Campan, D.J. Weisenberger, and P.W. Laird -- Genome-wide analysis of DNA methylation changes in human malignancies / C. Plass and D.J. Smiraglia -- Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island / N. Watanabe ... [et.al.] -- Methylation of endogenous human retroelements in health and disease / W. A. Schulz, C. Steinhoff, and A.R. Florl -- Cancer-linked DNA hypomethylation and its relationship to hypermethylation / M. Ehrlich.
  • Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
  • The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
  • Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina ... [et al.] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev ... [et al.] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir ... [et al.] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico ... [et al.] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer ... [et al.] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss ... [et al.] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier.
  • Cell Biology of Prostate Cancer and Molecular Targets / Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang -- Part I. Hormone Therapy. Luteinizing Hormone-Releasing Hormone and its Agonistic, Antagonistic, and Targeted Cytotoxic Analogs in Prostate Cancer / Andrew V. Schally and Norman L. Block ; Nuclear Receptor Coregulators: Promising Therapeutic Targets for the Treatment of Prostate Cancer / Hannelore V. Heemers and Donald J. Tindall ; Androgens and Prostate Cancer / Douglas K. Price and Ann W. Hsing ; Androgen Receptor Biology in Prostate Cancer / Edward P. Gelmann ; Androgen Receptor Antagonists / Howard C. Shen, Mary-Ellen Taplin, and Steven P. Balk ; 5-Alpha Reductase Inhibitors in Prostate Cancer / Zoran Culig ; Adrenal Androgen Synthesis Inhibitor Therapies in Castration-Resistant Prostate Cancer / Terence W. Friedlander and Charles J. Ryan ; Androgen Deprivation Therapy / Nima Sharifi ; Pharmacogenetics of the Androgen Metabolic Pathway / Francine Zanchetta Coelho Marques, and Juergen K.V. Reichardt -- Part II. Chemotherapy. Mitoxantrone / Patricia Halterman, Nicholas J. Vogelzang, Alireza Farabishahadel, and Oscar B. Goodman Jr. ; Docetaxel / Courtney K. Phillips and Daniel P. Petrylak ; Beyond Docetaxel: Emerging Agents in the Treatment of Advanced Prostate Cancer / Jonathan Rosenberg ; Platinum Agents in Prostate Cancer / Ashley Brick, Junyang Niu, Jiaoti Huang, and William K. Oh ; Clinical Pharmacology and Pharmacogenetics of Chemotherapy in Prostate Cancer / Tristan M. Sissung and William D. Figg ; Microtubule Targeting Agents / Antonio Tito Fojo and David E. Adelberg -- Part III. Angiogenesis. Principles of Antiangiogenic Therapy / Cindy H. Chau and William D. Figg ; Bevacizumab in Advanced Prostate Cancer / Aymen A. Elfiky and William Kevin Kelly ; Thalidomide and Analogs / Erin R. Gardner, Giuseppe Di Lorenzo, and William D. Figg ; Investigational Angiogenesis Inhibitors / Jeanny B. Aragon-Ching and William Dahut ; Pharmacogenetics of Angiogenesis / Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Francesco Crea, Mario Del Tacca, and Romano Danesi -- Part IV. Bone Metastasis. Pathophysiology of Prostate Cancer Bone Metastasis / Evan T. Keller and Christopher L. Hall ; Radiopharmaceuticals / Oliver Sartor and Damerla R. Venugopal ; Bisphosphonates for Prevention and Treatment of Bone Metastases / Philip J. Saylor and Matthew R. Smith ; Endothelin Receptors as Therapeutic Targets in Castration-Resistant Prostate Cancer / Joel B. Nelson ; Calcitriol and Vitamin D Analogs / Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, and Edwin M. Posadas -- Part V. Immunotherapy. Cancer Immunology, Immunotherapeutics, and Vaccine Approaches / Ravi A. Madan, James L. Gulley, Jackie Celestin, Philip M. Arlen, and Jeffrey Schlom ; Sipuleucel-T (APC8015): Active Cellular Immunotherapy for Advanced Metastatic Castration-Resistant Prostate Cancer / Celestia S. Higano and Mark W. Frohlich ; GM-CSF Gene-Transduced Prostate Cancer Vaccines: GVAX / Lalit R. Patel and Jonathan W. Simons ; CTLA-4 Blockade for Prostate Cancer Treatment / Andrea L. Harzstark and Lawrence Fong -- Part VI. Prevention. Prostate Cancer Chemoprevention Strategies / Howard L. Parnes, Margaret G. House, and Joseph A. Tangrea ; Diet and Prostate Cancer Incidence, Recurrence, and Progression Risk / June M. Chan and Erin L. Richman ; Inflammation as a Target in Prostate Cancer / Marshall Scott Lucia, James R. Lambert, Elizabeth A. Platz, and Angelo M. De Marzo -- Part VII. Drug Development. Challenges for the Development of New Agents in Prostate Cancer / Ajjai S. Alva, Deborah A. Bradley, and Maha Hussain ; FDA Approval of Prostate Cancer Treatments / Yang-Min Ning, Ramzi N. Dagher, and Richard Pazdur ; Applications of Proteomics in Prostate Cancer / Mitchell Gross, Edward Macrohon Nepomuceno, and David B. Agus.
  • Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakács ... [et al.] -- Metastasis and Drug Resistance / Dominic Fan ... [et al.] -- The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama ... [et al.] -- Mechanisms of Resistance to targeted Tyrosine Kinase Inhibitors / Stacey J.Baker, E. Premkumar Reddy -- Targeting Transglutaminase-2 to overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- Extracellular Matrix-Mediated Drug Resistance / P.S. Hodkinson, Tariq Sethi -- Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- Nuclear Factor-kB and Chemoresistance / Ajaikumar B.Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- Drug Resistance and the Tumor Suppressor p53 : The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- Resistance to Differentiation Therapy / Bulent Ozpolat -- MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong.
  • "Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting."
  • Dynamics of cancer 2007, NCBI Bookshelf
    Age of cancer incidence -- Multistage progression -- History of theories -- Progression dynamics -- Theory I -- Theory II -- Genetics of progression -- Carcinogens -- Aging -- Inheritance -- Stem cells : tissue renewal -- Stem cells : population genetics -- Cell lineage history.
  • Clinically relevant study end points in rectal cancer -- Neoadjuvant treatment in rectal cancer : do we always need radiotherapy or can we risk assess locally advanced rectal cancer better? -- Treatment dilemmas in patients with synchronous colorectal liver metastases -- Pancreatic surgery : beyond the traditional limits -- Adjuvant therapy for pancreatic cancer -- Radiotherapy of the pancreas : state of the art in 2012 -- Adenocarcinoma of the GEJ : gastric or oesophageal cancer? -- Why is there a change in patterns of GE cancer? -- Endoscopic treatment for esophageal squamous cell carcinoma -- Open or minimally invasive resection for oesophageal cancer? -- Choosing the best treatment for esophageal cancer -- Multimodal therapy of GEJ cancer : when is the definitive radiochemotherapy the treatment of choice? -- Radiotherapy of gastroesophageal junction cancer -- Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography -- Optimal surgery for gastric cancer : is more always better? -- Can adjuvant chemoratiotherapy replace extended lymph node dissection in gastric cancer? -- Predicting the response to chemotherapy in gastric adenocarcinoma : who benefits from neoadjuvant chemotherapy? -- Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients -- Adjuvant chemotherapy : an option for Asian patients only? -- Selecting the best treatment for an individual patient.
  • Introduction --Roles of EBNA1 at EBV Episomes --EBNA1-DNA Interactions --EBNA1 Contributions to EBV-Associated Tumours --Cellular Effects of EBNA1 --Conclusion.
  • ECTO-NOX proteins 2013, Springer
    "ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
  • EGF receptor family 2004, ScienceDirect
  • EGFR inhibitors in cancer treatment / Fortunato Ciardiello -- Mechanisms of action of EGFR inhibitors / Nicola Normanno, Maria Pergameno, Alessia Iannaccone & Antonella De Luca -- Selection of NSCLC patients to treat with EGFR inhibitors in the era of personalized medicine / Rafael Rosell, Laura Bonanno & Miquel Taron -- Clinical results with EGFR inhibitors in NSCLC and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- Clinical results with EGFR inhibitors in colorectal cancer / Erika Martinelli, Teresa Troiani, Floriana Morgillo & Fortunato Ciardiello -- EGFR-directed therapies in squamous cell carcinoma of the head and neck / Pol Specenier & Jan B. Vermorken -- Optimal use of EGFR inhibitors : challenges, new drugs and future directions / Sara De Dosso, Rodrigo Dienstmann & Josep Tabernero.
  • Electric Cell-Substrate Impedance Sensing Concept to Commercialization /Ivar Giaever and Charles R. Keese --Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance /Havovi Chichger, Katie L. Grinnell and Elizabeth O. Harrington --ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN) /Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason and Wen G. Jiang --Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening /Bryan Plunger, Chang Kyoung Choi and Tim E. Sparer --Epithelial-Mesenchymal Transition and the Use of ECIS /Jane Lane and Wen G. Jiang --Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing /Judith Anthea Stolwijk, Stefanie Michaelis and Joachim Wegener --Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing) /Tracey A. Martin and Wen G. Jiang --Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS: Electric Cell-Substrate Impedance Sensing in Epithelial Research /Katalin Szaszi, Matthew Vandermeer and Yasaman Amoozadeh --Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses /Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan and Nicholas Topley, et al. --Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells /Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest and Wen G. Jiang --Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents /Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang and Chun Hay Ko, et al. --ECIS, Cellular Adhesion and Migration in Keratinocytes /David C. Bosanquet, Keith G. Harding and Wen G. Jiang --Current and Future Applications of ECIS Models to Study Bone Metastasis /Lin Ye, Sivan M. Bokobza, Howard G. Kynaston and Wen G. Jiang.
  • Elephant in the room 2012, Springer
    Rick's Big Adventure -- All My Trials -- Fish Ate My Cancer -- Smoker's Cough -- Conference With Counsel -- Coming Through -- Here's Henry -- Why Me? -- How Do They Know What I've Got? -- Doctors and Cancer: Firewall.
  • Emerging applications of colloidal noble metals in cancer nanomedicine / Jian Zhang & Joseph R. Lakowicz -- Particle characterizations and synthesis methods / Jian Zhang & Joseph R. Lakowicz -- Diagnostics and treatments / Anna M. Sitarski, Jeremy L. Grant, Sanjeev Kumar Kandpal & Michael D. Mason -- Photothermal agents for cell theranostics / Dmitri O. Lapotko -- Drug delivery carriers / Marie-Christine Daniel -- Other applications and future directions / Ismail Ocsoy, Tao Chen & Weihong Tan -- Applications of noble metal nanoparticles in fluorescence sensing / Yi Fu -- Index.
  • Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies. In this environment it is essential to facilitate communication and understanding of new ideas and concepts. Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research. This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.
  • Emerging therapeutics for melanoma / Francesco M. Marincola, Paolo Ascierto & John M. Kirkwood -- Melanoma pathophysiology and drug targets / Giuseppe Palmieri, Carla Rozzo, Giusy Gentilcore & Paolo Antonio Ascierto -- Melanoma classification, diagnosis and staging / Mohammed Kashani-Sabet -- Melanoma prevention / Pamela B. Cassidy, Douglas Grossman & Sancy A. Leachman -- Surgical treatment of melanoma : from excision to sentinel node biopsy / Nicola Mozzillo & Corrado Caracò -- Adjuvant therapy in melanoma / Diwakar Davar, Ahmad A. Tarhini & John M. Kirkwood -- Immunostimulatory monoclonal antibodies for melanoma treatment / Miguel Fernandez de Sanmamed, Jose L. Perez-Gracia, Salvador Martín-Algarra & Ignacio Melero -- New signal transduction inhibitors / Keith T. Flaherty -- Melanoma vaccines in development / Ruggero Ridolfi, Laura Ridolfi, Stefania V.L. Nicoletti & Massimo Guidoboni -- Melanoma and biomarkers of immunoresponsiveness : predicting the clinical outcome of immunotherapy / Davide Bedognetti, Ena Wang, Mario Roberto Sertoli & Francesco M. Marincola -- Uveal melanoma / Paola Queirolo, Graziano Caltabiano & Francesco Spagnolo -- Management of melanoma brain metastases in the era of targeted therapies / Daniela Gonsalves Shapiro, Michael T. Shapiro & Wolfram E. Samlowski -- Which therapy for which patient? / Antoni Ribas -- Index.
  • V. 1. A-B -- v. 2. C -- v. 3. D-G -- v. 4. H-L -- v. 5. M-O -- v. 6. P-R -- v. 7. S-Z.
  • SECTION I: SCIENTIFIC FOUNDATIONS OF RADIATION ONCOLOGY -- Part A: Radiobiology -- Part B: Physics -- SECTION II: Techniques and Modalities -- SECTION III: DISEASE SITES -- Part A: Central Nervous System Tumors Overview -- Part B: Head and Neck Tumors Overview -- Part C: Thoracic Neoplams Overview -- Part D: Gastrointestinal Tumors Overview -- Part E: Genitourinary Tumors Overview -- Part F: Gynecologic Tumors Overview -- Part G: Breast Cancer Overview -- Part H: Sarcoma and Benign Disease -- Part I: Childhood Cancers Overview -- Part J: Lymphoma & Hematologic Malignancies Overview.
  • Endocrine neoplasia 2010, Springer
    Part. I Thyroid.-- Biology of thyroid oncogenesis / Insoo Suh, Electron Kebebew.-- Evaliation of the thyroid nodule / Dina M. Elaraj.-- Differentiated thyroid cancers of follicular cell origin / Linwah Yip, Sally E. Carty.-- Sporadic medullary thyroid cancer / Adrian Harvey, Janice L. Pasieka.-- Anaplastic thyroid cancer / Alan P.B. Dackiw.-- Part II. Parathyroid.-- Primary hyperparathyroidism / Kaitlyn J. Kelly, Herbert Chen, Rebecca S. Sippel.-- Parathyromatosis and parathyroid cancer / Wen T. Shen.-- Part III. Incidentaloma / Jacob Malem, Insoo Suh, Quan-Yang Duh.-- Pheochromocytoma and paraganglioma / Goswin Y. Meyer-Rochow, Stan B. Sidhu.-- Functional cortical neoplasms / Ali Zarrinpar, Michael W. Yeh.-- Adrenocortical carcinoma / Patsy S.H. Soon, Stan B. Sidhu.-- Part IV. Pnacreatic neuroendocrine tumors.-- Gastrinoma / Anthony J. Chambers, Janice L. Pasieka.-- Insulinoma / Kimberly Vanderveen, Clive Grant.-- Rare neuroendocrine tumors of the pancreas / Shih-Ping Cheng, Gerard M. Doherty.-- Part V. Multiple endocrine neoplasia.-- Menin gene / Hsin-Chieh Jennifer Shen, Steven K. Libutti.-- Multiple endocrine neoplasia type I: clinical manifestations and management / Anathea C. Powell, Steven K. Libutti.-- RET protooncogene / Amber L. Traugott, Jeffrey F. Moley.-- Multiple endocrine neoplasia type 2: clinical manifestations and management / Amber L. Traugott, Jeffrey F. Moely.
  • Multiple endocrine neoplasia type 1 / Agarwal, S.K. -- Multiple endocrine neoplasia type 2 / Lodish, M. -- Von Hippel-Lindau syndrome / Chou, A. ... [et al.] -- Carney complex -- Espiard, S., Bertherat, J. -- Multiple endocrine neoplasia type 4 / Lee, M., Pellegata, N.S. -- Novel hereditary forms of pheochromocytomas and paragangliomas / Dahia, P.L.M. -- Carney triad / Carney, J.A. -- Genetics of pituitary adenomas / Gadelha, M.R. ... [et al.] -- Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer / Bauer, A.J. -- Genetic defects associated with familial and sporadic hyperparathyroidism / Hendy, G.N., Cole, D.E.C. -- Endocrine tumors associated with neurofibromatosis type 1, Peutz-Jeghers syndrome, and other familial neoplasia syndromes / Kalkan, E., Waguespack, S.G.
  • Hypopituitarism following radiotherapy revisited / Darzy, K.H., Shalet, S.M. -- Alterations in pubertal timing following therapy for childhood malignancies / Armstrong, G.T., Chow, E.J., Sklar, C.A. -- Obesity during and after treatment for childhood cancer / Reilly, J.J. -- Metabolic disorders / Gregory, J.W. -- Bone and bone turnover / Crofton, P.M. -- Male fertility and strategies for fertility preservation following childhood cancer treatment / Mitchell, R.T. ... [et al.] -- Fertility in female childhood cancer survivors / De Bruin, M.L. ... [et al.] -- Long-term follow-up of survivors of childhood cancer / Edgar, A.B. ... [et al.].
  • Current status of the prevention and early diagnosis of endometrial adenocarcinoma -- The value of endometrial cytology -- Techniques of endometrial cytology -- Techniques of endometrial histopathology -- New techniques for the diagnosis of endometrial pathology -- Cytology of the normal endometrium - cycling and postmenopausal -- Benign endometrial lesions -- Cytopathology of endometrial hyperplasias -- Cytopathology of endometrial adenocarcinoma -- Cytopathology of the non-epithelial malignant tumors of the uterine corpus.
  • Endoscopic oncology 2006, Springer
    Barrett's esophagus : screening, diagnosis, and management / Glenn M. Eisen -- Endoscopic screening for squamous cell carcinoma of the esophagus / Brian C. Jacobson -- Image enhancement endoscopy / Stephan M. Wildi and Michael B. Wallace -- Staging of esophageal cancer / Jason Vollweiler and Gregory Zuccaro, Jr. -- Endoscopic therapy for early esophageal cancer and premalignant lesions in Barrett's esophagus / Granapathy A. Prasad and Kenneth K. Wang -- Endoscopic therapy for advanced esophageal cancer / Sanjay Jagannath and Marcia I. Canto -- Radiological imaging of the upper gastrointestinal tract / Marc S. Levine -- Esophageal cancer therapy : surgery, radiation, and chemotherapy / John M. Holland and Christopher A. Canning -- Premalignant lesions of the stomach / Omid A. Shaye and Andrew Ippoliti -- Gastric polyps / George A. Makar and Gregory G. Ginsberg -- Endoscopic ultrasound for staging gastric cancer / Gregory Olds and Amitabh Chak -- Endoscopic treatment for gastric cancer / Takuji Gotoda and Roy M. Soetikno -- Diagnosis and management of gastrointestinal lymphoma / John G. Kuldau, Peter R. Holman, and Thomas J. Savides -- Gastrointestinal stromal tumors / Raquel E. Davila -- Carcinoid tumors / Wilscott E. Naugler and Gordon C. Hunt -- Medical and surgical therapy for gastric cancer / Diane Hershock -- Colorectal cancer screening / Jason A. Dominitz and William M. Grady --Polyposis and familial cancer syndromes / Fernando S. Velayos, Madhulika G. Varma, and Jonathan P. Terdiman -- Endoscopic colon surveillance : post-polypectomy, post-colorectal cancer resection, and inflammatory bowel disease / Douglas B. Nelson and Mandeep S. Sawhney -- Endoscopic ultrasound for staging rectal and anal cancer / Deepak V. Gopal -- Endoscopic therapy of colorectal carcinoma / Vaman Jakribettuu and Yang K. Chen -- Radiological imaging of the lower gastrointestinal tract / Steven E. Rubesin -- Current status of colorectal cancer therapy / John Strother ... [et al.] -- Cystic neoplasms of the pancreas / William R. Brugge -- Diagnosis and evaluation of pancreatic ductal adenocarcinoma / Kenneth H. Yu and Nuzhat A. Ahmad -- Adenocarcinoma of the pancreas : endoscopic palliation / Georgios I. Papachristou, Kevin McGrath, and Adam Slivka -- Pancreatic neuroendocrine tumors / Erik-Jan Wamsteker and James M. Scheiman -- Endoscopic diagnosis and management of cholangiocarcinoma / Vanessa M. Shami and Irving Waxman -- Ampullary neoplasia / Ian D. Norton -- Magnetic resonance imaging of neoplasms of the pancreatobiliary system / Evan S. Siegelman and Wendy C. Hsu -- Medical and surgical therapy of pancreatic cancer / Weijing Sun, Jon Morris, and Jeffrey Drebin -- Endoscopic ultrasound for thoracic disease / Timothy Woodward, Massimo Raimondo, and Michael B. Wallace.
  • Endourooncology 2005, Springer
    Merging of endourology and oncology: endourooncology / A. El-Hakim, B.R. Lee, and A.D. Smith -- Surgical robots and three-dimensional displays for computer-aided surgery / T. Dohi -- Robot-assisted (Da Vinci) urologic surgery: an emerging frontier / A.K. Hemal and M. Menon -- Robotic surgery assisted by the ZEUS system / M. Eto and S. Naito -- Telesurgery: remote monitoring and assistance laparoscopy / T. Inagaki, S.B. Bhayani, and L.R. Kavoussi -- Remote percutaneous renal access using a telesurgical robotic system / B. Challacombe, L. Kavoussi, and D. Stoianovici -- Radiofrequency ablation for percutaneous treatment of malignant renal tumors / S. Kanazawa, T. Iguchi, K. Yasui, H. Mimura, T. Tsushima, and H. Kumon -- High-intensity focused ultrasound for noninvasive renal tumor thermoablation / A. Häckr, M.S. Michel, and K.U. Köhrmann -- High-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer / T. Uchida, H. Ohkusa, H. Yamashita, and Y. Nagata -- Renal cryoablation / K. Nakagawa and M. Murai -- Prostate cryoablation / B.J. Donnelly and J.C. Rewcastle -- Tumor control outcome and tolerance of permanent interstitial implanation for patients with clinically localized prostate cancer / Y. Nasu, F. Abarzua, and H. Kumon.
  • Energy balance and cancer v. 1-, 2011-, Springer
  • The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
  • The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and fat metabolism. This volume on Energy Balance in Hematologic Malignancies will provide an important volume in this series and a basis for better understanding etiology, mechanisms, therapeutics implications and experimental approaches. This volume of energy balance and cancer will focus on the relation of obesity to hematologic malignancies, the epidemiology, potential mechanisms, and thereapeutic considerations including effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance.
  • Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer /Robert A. Hiatt --Puberty as a window of susceptibility /Frank M. Biro and Mary S. Wolff --In search of the optimal experimental model /Irma H. Russo and Jose Russo --Early life exposure to bisphenol A and breast neoplasia /Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto --Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages /Ricardo Lopez de Cicco ... [et al.] --Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A /Sarah Jenkins ... [et al.] --Dioxin as an environmental pollutant and its role in breast cancer /Stephen Safe, Kelcey Walker, and Shu Zhang --Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse /Sally S. White ... [et al.] --Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility /Jennifer L. Rayner and Suzanne E. Fenton --Biological impact of radiation exposure on breast cancer development /David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff --Brain estrogens and metabolism /Yong Xu and Deborah J. Clegg.
  • The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.
  • Part 1. General Principles -- Introduction / Deodutta Roy and M. Tevfik Dorak -- Gene-Environment Interactions, Phenotypic Changes, and Human Health / Rosemarie G. Ramos and Kenneth Olden -- Statistics for Testing Gene-Environment Interaction / Momiao Xiong and Xuesen Wu -- Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers / Richard J.Q. McNally -- Discovering Gene-Gene and Gene-Environment Causal Interactions Using Bioinformatics Approaches / Changwon Yoo -- Gene Environment Interactions and Vascular Lesions / Quentin Felty -- Epigenetic Changes in Cancer: Role of Environment / Zdenko Herceg and Paolo Boffetta -- Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility / Alok Deoraj and Deodutta Roy -- Part 2. Environment and Specific Types of Cancer -- Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors / Brian Kunkle, David Sandberg, Prasanna Jayakar, Quentin Felty and Deodutta Roy -- Genetic Polymorphisms Predisposing Individuals to Breast Cancer Via Gene-Environment Interaction / Keun-Young Yoo, Sue K. Park and Aesun Shin -- Environment, Genetic Immunology and Childhood Cancer / Esma Ucisik-Akkaya and M. Tevfik Dorak -- Exposure to Environmental Mutagens: APC and Colorectal Carcinogenesis / Aruna S. Jaiswal, Melissa L. Armas, Shahnjayla K. Connors, Harekrushna Panda and Satya Narayan -- Gene-Environmental Interactions and Susceptibility to Liver Cancer / John B. Colerangle -- Genetic Epidemiology of Mismatch Repair Deficiency in Ovarian Cancer / Tuya Pal, Jenny Permuth Wey and Thomas A. Sellers -- Part 3. Case Studies -- Betel Nut and Susceptibility to Cancer / Rajesh N. Sharan and Yashmin Choudhury -- Birth Weight and Cancer Associations / Nadia Barahmani and M. Fatih Okcu -- Iron Excess and Cancer / Charronne F. Davis and M. Tevfik Dorak.
  • Epidermal cell tumors 2011, Springer
    Benign melanocytic proliferations -- Essential criteria for diagnosing melanoma -- Histologic mimics of malignant melanoma -- Epidermal neoplasms -- Pilosebaceous neoplasms -- Tumors with eccrine differentiation -- Merkel cell carcinoma.
  • The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chimeric, leukemia-specific transcription factors. This book first presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
  • Epigenetics 2013, Springer
    Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.
  • Epigenetics and cancer 2013, Springer
    Systems and Network Biology to Investigate Epigenetic De-regulatory Mechanisms of MicroRNAs in Pancreatic Cancer /Irfana Muqbil, Fazlul H. Sarkar, Ramzi M. Mohammad --Role of MicroRNAs in Cancer Epigenetics /Kishore B. Challagundla, Petra Wise, Muller Fabbri --Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs /Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong --Epigenetics and MicroRNAs in Renal Cancer /Shahana Majid ... [et al.] --Epigenetic Regulation of MicroRNA in Colon Cancer /Qiong Zhang, Mukesh Verma, Sharad Khare --Epigenetic Regulation of miRNAs in Breast Cancer Formation and Progression /Zhiqian Zhang ... [et al.] --Epigenetic Variations of Stem Cell Markers in Cancer /Sripathi M. Sureban, Dongfeng Qu, Courtney W. Houchen --Recent Updates on Epigenetic Biomarkers for Prostate Cancer /Karen Chiam, Tanya Kate Day, Tina Bianco-Miotto --Epigenetics and Racial Disparities in Prostate Cancer /Benjamin A. Rybicki --Epigenetic Signatures of Breast Cancer Genes /Shrikant Anant, Animesh Dhar, Satish Ramalingam --Exploiting Epigenetic Modifiers to Circumvent Melanoma Dual Resistance to TCR-Engineered Immunotherapy- and BRAF V⁶⁰⁰E-Kinase Inhibitor /Ali R. Jazirehi CLS, --The Role of Epigenetics in Radiation Therapy and the DNA Damage Response /Steven P. Zielske --Plant Polyphenols as Epigenetic Modulators of Glutathione S-Transferase P1 Activity /Vijay S. Thakur, Sanjay Gupta --Epigenetic Regulations of mRNAs and miRNAs by Nutraceuticals /Yiwei Li ... [et al.] --Towards Curative Cancer Therapy with Maspin: A Unique Window of Opportunity to Target Cancer Dormancy /Alexander Kaplun, M. Margarida Bernardo, Sijana Dzinic.
  • The Normal Breast -- Specimen Processing -- Fibrocystic Change and Duct Ectasia -- Adenosis -- Intraductal Proliferative Lesions -- Intraductal Papillary Neoplasms -- Lobular Intraepithelial Neoplasia (LIN) -- Infiltrating Ductal Carcinoma (NOS Type) -- Invasive Lobular Carcinoma (ILC) -- Special Types of Breast Carcinomas -- Biphasic Tumors -- Disease of the Nipple -- Male Breast Lesions -- Mesenchymal Lesions/Tumors -- Myoepithelial Lesions/Neoplasms -- Miscellaneous Lesions -- Cytopathology of Benign and Malignant Lesions (Selected Topics) -- Immunohistochemistry (Selected Topics).
  • This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.
  • Historical Introduction --Descriptive Biostatistics --Inferential Biostatistics (I): Estimating Values of Biomedical Magnitudes --Inferential Biostatistics (II): Estimating Biomedical Behaviors --Equations: Formulating Biomedical Laws and Biomedical Magnitudes --Systems of Equations: The Explanation of Biomedical Phenomena (I). Basic Questions --Systems of Equations: The Explanation of Biomedical Phenomena (II). Dynamic Interdependencies --Optimal Control Theory: From Knowledge to Control (I). Basic Concepts --Optimal Control Theory: From Knowledge to Control (II). Biomedical Applications --Game Theory.
  • Although it is well established that the worldwide pandemic of overweight and obesity has profound effects on promoting cancer, it is now recognized that alternative aspects of energy balance, namely physical activity and exercise have significant beneficial effects on all aspects of cancer across the spectrum from prevention through treatment and extending through survivorship. While the effect of physical activity and exercise on cancer may be partially mediated through obesity control, it is clear that considerable research is required and is ongoing at both the molecular and clinical levels to better understand the associated mechanisms and to develop optimal exercise strategies. This volume presents the effects of exercise on biological pathways in tumor growth, state of the art exercise strategies and cutting edge research focused on different cancers and patient groups. This important text will provide a basis for ongoing research, experimental approaches and application of evidence based practices to clinical care for patients with cancer.
  • T cell therapy: state-of-the-art -- Extending the use of adoptive T cell immunotherapy for infections and cancer -- Non-T cell therapeutic approaches -- B lymphocytes in cancer immunology -- Monoclonal antibody therapy for cancer -- Natural killer cells for cancer immunotherapy -- Dendritic cell-based cancer vaccines: practical considerations -- Mesenchymal stromal cells: an emerging cell-based pharmaceutical -- T cell therapeutic approaches -- Tumor-specific mutations as targets for cancer immunotherapy -- Counteracting subversion of MHC class II antigen presentation by tumors -- Mechanisms and implications of immunodominance in CD8⁺ T-cell responses -- T regulatory cells and cancer immunotherapy -- Negative regulators in cancer immunology and immunotherapy -- Genetically engineered antigen specificity in T cells for adoptive immunotherapy -- Non-cellular aspects of cancer immunotherapy -- Cytokine immunotherapy -- Transcriptional modulation using histone deacetylase inhibitors for cancer immunotherapy -- Combining cancer vaccines with conventional therapies -- Combining oncolytic viruses with cancer immunotherapy -- Radiation therapy and cancer treatment: from the basics to combination therapies that ignite immunity -- Assessing immunotherapy through cellular and molecular imaging -- Transplantation -- Allogeneic and autologous transplantation therapy of cancer: converging themes.
  • The primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well established and usually results in local control, treating metastatic disease is a much more daunting task. At diagnosis, few patients present with clinically detectable metastatic lesions regardless of the clinical prognostic factor. Clinical trials assessing potential therapeutic agents are important in order to define the best specific treatment for a particular patient, which are the basis for patient-oriented research that eventually lead to personalized medicine.This volume aims to comprehensively present the latest research and information about metastasis. Understanding the mechanisms underlying the metastatic phenomenon could have vast implications for the large number of patients who are at a high risk for the development of metastasis.
  • Extranodal lymphomas 2011, ScienceDirect
    Introduction to extranodal lymphomas / Judith A. Ferry -- Lymphomas of the nervous system and the meninges / Judith A. Ferry -- Lymphomas of the head and neck / Judith A. Ferry -- Lymphomas of the thorax / Judith A. Ferry -- Lymphomas of the esophagus, gastrointestinal tract, hepatobiliary tract, and pancreas / Judith A. Ferry -- Lymphomas of the spleen / Aliyah R. Sohani and Lawrence R. Zukerberg -- Adrenal lymphomas / Judith A. Ferry -- Lymphomas of the urinary tract / Judith A. Ferry -- Lymphomas of the male genital tract / Judith A. Ferry -- Lymphomas of the female genital tract / Judith A. Ferry -- Cutaneous lymphomas / Lyn M. Duncan, Johanna l. Baran, and Judith A. Ferry -- Lymphomas of bone / Judith A. Ferry -- Lymphomas of the bone marrow / Robert P. Hasserjian -- Intravascular lymphomas / Judith A. Ferry.
  • FDG PET/CT has rapidly emerged as an invaluable combined imaging modality that can identify tumors on the basis of not only anatomical alterations but also metabolic activity, thus allowing the detection of lesions that would otherwise be too small to distinguish. This book, comprising a collection of images from oncology cases, is organized according to the role of FDG PET/CT in the evaluation and management of oncology patients, and only secondarily by organ or tumor entity. In this way, it reflects the issues that clinicians actually address in their daily practice, namely: identification of an unknown or unsuspected primary; determination of the extent of disease; evaluation of response to therapy; and surveillance after response, i.e., detection of recurrent disease. In total, 100 cases involving different primary tumors are presented to illustrate findings in these different circumstances. FDG PET/CT in Clinical Oncology will be of great value to all newcomers to this field, whether medical students, radiology, nuclear medicine, or oncology fellows, or practicing physicians.
  • This book provides a detailed update on all aspects of fine-needle aspiration cytology of breast lesions. It will serve readers as an up-to-date reference and atlas on both new entities in breast pathology, including borderline lesions such as flat epithelial atypia, and the classic benign and malignant lesions. Throughout, emphasis is placed on the characteristic diagnostic features as well as the common pitfalls faced by cytologists. As cytologic features can be highly variable, corresponding cytology and histology images are displayed together, enabling readers to gain a good understanding of the morphologic features of various lesions. Core-needle biopsy and fine-needle aspiration cytology are compared in depth, with attention to their relative strengths and weaknesses and indications. In addition, the impact of molecular classification of breast cancers on cytologic diagnosis is explored, and the use of molecular techniques in diagnostic cytology is discussed.
  • Historical aspects -- Techniques -- Flow cytometry in fine-needle aspiration diagnosis of lymphomas / in collaboration with Anna Porwit-MacDonald -- B cell neoplasms -- T cell neoplasms -- Hodgkin lymphoma -- Lymphadenopathy in HIV-infected patients -- Histiocytic and dendritic neoplasms -- Extranodal lymphomas -- Lymphoma look-alike.
  • History, indications, technique and limitations / Singh, A.D. ... [et al.] -- Cytological preparation / Brainard, J.A., Biscotti, C.V. -- Uveal metastases / Biscotti, C.V., Singh, A.D. -- Uveal lymphoma / Chute, D.J., Biscotti, C.V., Singh, A.D. -- Uveal melanoma : diagnostic features / Biscotti, C.V., Singh, A.D. -- Uveal melanoma : prognostication / Turell, M.E. ... [et al.] -- Vitreous biopsy : specimen preparation and interpretation / Coupland, S.E. -- Fine needle aspiration biopsy of retinal tumors / Ali, M.J. ... [et al.] -- Fine needle aspiration cytology in orbital tumors / Seregard, S., Tani, E. -- Future of ophthalmic fine needle aspiration biopsy / Singh, A.D., Dolan, B., Biscotti , C.V.
  • Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method.
  • Cancer survivors -- The medical and psychological concerns of cancer survivors after treatment -- Delivering cancer survivorship care -- Providers of survivorship care: their supply and education and training -- Employment, insurance, and economic issues -- Research.
  • The origin and development of neural crest-derived melanocytes / Debra L. Silver and William J. Pavan -- MITF : a matter of life and death for the developing melanocytes / Heinz Arnheiter ... [et al.] -- MITF : critical regulator of the melanocyte lineage / Erez Feige, Laura L. Poling, and David E. Fisher -- Melanocytes and the transcription factor Sox10 / Michael Wegner -- Human cutaneous pigmentation : a collaborative act in the skin, directed by paracrine, autocrine, and endocrine factors and the environment / Zalfa A. Abdel-Malek and Ana Luisa Kadekaro -- Melanocyte distribution and function in human skin : effects of ultraviolet radiation / Yuji Yamaguchi and Vincent J. Hearing --Altered signal transduction in melanoma / Pablo López Bergami, Anindita Bhoumik, and Ze'ev Ronai -- BRN2 in melanocytic cell development, differentiation, and transformation / Anthony L. Cook ... [et al.] -- The dynamic roles of cell-surface receptors in melanoma development / Dong Fang and Meenhard Herlyn -- Familial melanoma genes, melanocyte immortalization, and melanoma initiation / Dorothy C. Bennett -- Genetic progression from melanocyte to malignant melanoma / Boris C. Bastian -- The multiple roles of the oncogenic protein SKI in human malignant melanoma / Dahu Chen ... [et al.] -- RB/E2F regulation and dual activity in the melanocytic system / Ruth Halaban -- Melanoma development and pigment cell transformation / Claudia Wellbrock -- The biology and genetics of melanoma / Norman E. Sharpless and Lynda Chin -- The biology of xeroderma pigmentosum : insights into the role of ultraviolet light in the development of melanoma / James E. Cleaver -- Divergent pathways to cutaneous melanoma / David C. Whiteman and Adéle C. Green -- Pigmentation, DNA repair, and candidate genes : the risk of cutaneous malignant melanoma in a mediterranean population / Maria Teresa Landi -- Low-penetrance genotypes, pigmentation phenotypes, and melanoma etiology / Peter A. Kanetsky and Timothy R. Rebbeck -- The biology of melanoma progression : from melanocyte to metastatic seeds / A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. -- Optical imaging analysis of atypical nevi and melanoma / Amanda Pfaff Smith and Dorothea Becker -- Proteomics analysis of melanoma cell lines and cultured melanocytes / Katheryn A. Resing and Natalie G. Ahn --Paradigm of metastasis for malignant melanoma / Stanley P.L. Leong -- Repair of UV-induced DNA damage and melanoma risk / Qingyi Wei -- High risk factors for melanoma metastasis / Neil A. Accortt and Seng-jaw Soong -- Role of melanoma inhibitory activity in early development of malignant melanoma / Anja-Katrin Bosserhoff -- Role and regulation of PAR-1 in melanoma progression / Carmen Tellez and Menashe Bar-Eli -- Molecular mechanisms of melanoma metastasis / Mohammed Kashani-Sabet -- Overview of tumor progression in melanoma / David E. Elder -- The plasticity of melanoma cells and associated clinical implications / Mary J. C. Hendrix ... [et al.] -- The clinical use of molecular markers as predictors of disease outcome and response to therapy in malignant melanoma / Steve R. Martinez, Hiroya Takeuchi, Dave S.B. Hoon -- The role of DCT/TYRP2 in resistance of melanoma cells to drugs and radiation / Brian J. Pak and Yaacov Ben-David -- How melanoma cells evade chemotherapy : role of transporter-dependent and -independent resistance mechanisms / Kevin G. Chen and Michael M. Gottesman -- Apoptosis in melanoma: approaches to therapy / Heicke Röckmann and Dirk Schadendorf -- Role of melanoma-associated antigens / Rishab K. Gupta, Ana M. McElrath-Garza, and Donald L. Morton -- Host responses to melanoma : implications for immunotherapy / Julian A. Kim and Ernest Borden -- Future perspectives / Vincent J. Hearing and Stanley P.L. Leong.
  • "The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away-in a scientifically accessible manner-from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions)"--Back cover.
  • Intraoperative evaluation of colorectal specimens containing cancer -- Intraoperative evaluation for extracolonic disease in colon cancer patients -- Metastases and mimics of colorectal carcinoma -- Non-epithelial tumors of the colorectum -- Frozen section assessment of the colorectum in the pediatric population -- Frozen section evaluation of the appendix -- Frozen section evaluation of anal disease.
  • 1. Sentinel Lymph Nodes -- 2. Assessment of the Surgical Margins -- 3. Diagnostic Evaluation of a Breast Mass -- 4. Handling of Specimens with a Nonpalpable Lesion -- 5. Core Needle Biopsies -- 6. Regulatory Requirements for Breast Specimens.
  • Ch. 1. Introduction -- Ch. 2. Potential to reduce the cancer burden through cancer prevention and early detection -- Ch. 3. Lifestyle behaviors contributing to the burden of cancer -- Ch. 4. Modifying health risk behaviors -- Ch. 5. Potential of screening to reduce the burden of cancer -- Ch. 6. Improving participation in cancer screening programs -- Ch. 7. Adopting new technology in the face of uncertain science: the case of screening for lung cancer -- Ch. 8. Professional education and training -- Ch. 9. Federal programs that support cancer prevention and early detection -- Ch. 10. Research trends and opportunities -- Ch. 11. Findings, policy implications, and recommendations.
  • This book presents a comprehensive overview of current state-of-the-art clinical physiological imaging of brain tumors.? It focuses on the clinical applications of various modalities as they relate to brain tumor imaging, including techniques such as blood oxygen level dependent functional magnetic resonance imaging, diffusion tensor imaging, magnetic source imaging/magnetoencephalography, magnetic resonance perfusion imaging, magnetic resonance spectroscopic imaging, amide proton transfer imaging, high angular resolution diffusion imaging, sodium imaging, and molecular imaging. Featuring contributions from renowned experts in functional imaging, this book examines the diagnosis and characterization of brain tumors, details the application of functional imaging to treatment planning and monitoring of therapeutic intervention, and explores future directions in physiologic brain tumor imaging. Intended for neuro-oncologists, neurosurgeons, neuroradiologists, residents, and medical students, Functional Brain Tumor Imaging is a unique resource that serves to advance patient care and research in this rapidly developing field.
  • Part I. Clinical and therapeutic approach to functional oncological imaging -- part II. Imaging of cancer hallmarks -- part III. Functional imaging techniques in clinical use -- part IV. Molecular imaging techniques in clinical use and in research.
  • Tumors of the CNS and Spinal Cord -- Functional Magnetic Resonance Techniques in CNS Tumors -- MR Imaging Evaluation of Posttreatment Changes in Brain Neoplasms -- Metastasis and Other Tumors of the CNS -- Spinal Cord Tumors: Anatomic and Advanced Imaging -- Head and Neck Cancer -- Chest Malignancies -- Lung Cancer: PET, Perfusion CT, and Functional MR Imaging -- Functional Imaging of Malignant Pleural Mesothelioma and other Pleural and Chest Wall Lesions -- Functional Imaging of Malignant Pleural Mesothelioma and other Pleural and Chest Wall Lesions -- Thymomas and Other Thymic Primary Malignancies of the Chest -- Functional Imaging in Cardiac Tumors -- Women's Cancers -- Breast Cancer -- PET-CT of Gynecological Malignancies and Ovarian Cancer -- Functional MRI of Uterine (Endometrial and Cervical) Cancer -- Functional Imaging of Ovarian Cancer and Peritoneal Carcinomatosis -- Malignancies of the Gastrointestinal System -- Esophagus, Stomach, and Small Bowel Malignancies -- Colorectal Cancer -- Hepatobiliary and Pancreatic Malignancies -- Overview of Functional Imaging Techniques for Liver Malignancies in Current Clinical Practice or in a Very Near Future -- Hepatocellular Carcinoma -- Role of Functional MRI in the Management of Liver Metastases -- Other Malignant Lesions of the Liver -- Functional Imaging of Gallbladder and Biliary Malignancies -- Splenic Lesions -- Genitourinary Tract Tumors -- Functional Imaging of Renal Cell Carcinoma -- Functional CT and MRI of the Urinary System and Adrenal Glands -- Prostate Cancer -- Scrotum -- Functional Imaging of Tumors of the Mesenterium and Retroperitoneum -- Malignancies of the Endocrine System -- Functional Oncological Imaging of the Endocrine System -- Hematological Malignancies -- Functional Imaging in Clinical Use for the Assessment of Lymph Nodes in Oncological Patients -- Functional Imaging in Lymphoma -- Multiple Myeloma and Other Hematological Malignancies -- Malignant Tumors of the Musculoskeletal System -- Advanced MRI Techniques of Soft Tissue Tumors -- Bone Malignancies -- Bone Metastasis -- Functional Imaging of Pediatric Malignancies -- Malignant Melanoma.
  • Introduction of cancer prevention -- Assessing human and economic benefits of cancer prevention -- The role of diet, physical activity and body composition in cancer prevention -- Hereditary risk for cancer -- Human categories and health: the power of the concept of ethnicity -- Complementary and alternative approaches to cancer prevention -- The drug development process -- Developing topical prodrugs for skin cancer prevention -- Skin cancer prevention -- Colorectal cancer prevention -- Lung cancer prevention -- Breast cancer prevention -- Prostate cancer prevention -- Cervical and endometrial cancer prevention -- Ovarian cancer prevention -- Cancer survivorship.
  • Gamma knife neurosurgery 2011, Springer
    Introduction and the nature of radiosurgery -- Principles of stereotaxy -- Ionizing radiation and its effects on living tissue -- Biological effects of ionizing radiation -- Ionizing radiation and clinical practice -- Gamma knife development from 1967 to 2010 -- Radiophysics, radiobiology and the gamma knife -- Preparation for treatment planning -- Dose plan indices -- Gamma knife surgery and computer networks -- Aims of gamma knife surgery -- Principles of information and follow up -- Vestibular schwannomas -- Meningiomas -- Gamma knife for cerebral metastases -- Intraparenchymal intrinsic brain tumors -- Tumors of the pituitary region -- Less common skull base tumors -- Gamma knife for cerebral vascular anomalies -- Trigeminal neuralgia -- Diverse functional indications -- Rare tumors and other lesions -- Orbital indications -- Conclusion and possible future trends.
  • Gastrointestinal cancer 2005, Springer
  • Gene therapy for cancer 2007, Springer
    Adenovector-mediated cancer gene therapy /Bingliang Fang and Jack A. Roth --Efficacy, toxicity, and immunogenicity of adenoviral vectors /Dmitry M. Shayakhmetov --Lentiviral and retroviral vector systems /Renata Stripecke and Noriyuki Kasahara --Vaccinia and pox-virus /Sricharan Chalikonda and David L. Bartlett --Herpes simplex virus as a therapy for cancer /Ian J. Mohr --Alphavirus vectors for gene therapy applications /Kenneth Lundstrom --Vesicular stomatitis virus and RNA viruses as gene therapy vectors /Glen N. Barber --Parvovirus vectors /Selvarangan Ponnazhagan --Nonviral vector systems /Pui-yan Lee and Leaf Huang --Oncogenes, tumor suppressor genes, and apoptosis-inducing genes utilized in cancer gene therapy /Lidong Zhang and Bingliang Fang --Gene silencing therapy against cancer /Chao-Zhong Song --Tumor targeting-retargeted adenovirus /Masato Yamamoto and David T. Curiel --Oncolytic herpes simplex for gene therapy in preclinical and clinical trials /Richard H. Pin ... [et al.] --Cytokine gene therapy for genitourinary cancer /Terry L. Timme ... [et al.] --Combination of gene therapy with radiation /Anupama Munshi and Raymond E. Meyn --Gene transfer for chemoprotection and enrichment of hematopoietic stem cells /Justin C. Roth and Stanton L. Gerson --Nonviral genetic vaccines for cancer /Steven R. Little, Daniel G. Anderson, and Robert Langer --Gene therapy targeted at angiogenesis and lymphangiogenesis for cancer treatment /Anita T. Tandle and Steven K. Libutti --Tumor-specific replicating adenoviruses : delta 24 for human gliomas /Giacomo G. Vecil, Juan Fueyo, and Frederick F. Lang --Problems, side effects, and disappointments in clinical cancer gene therapy /Ta-Chiang Liu and David H. Kirn --Trials and tribulations in developing clinical trials of gene therapy : E1A for breast or ovarian cancer /Naoto T. Ueno ... [et al.] --Phase I clinical experience with intravenous administration of PV701, an oncolytic virus /Andrew L. Pecora and Robert M. Lorence --MDA-7/IL-24 as a multi-modality therapy for cancer /Sunil Chada ... [et al.] --Development of therapeutic genes for breast cancer treatment /Mien-Chie Hung and Duen-Hwa Yan --Steps in a translational cancer gene therapy trial /Urs W. von Holzen and Stephen G. Swisher.
  • General principles of tumor immunology -- A perspective on cancer immunology and immunotherapy -- Tumor antigens -- T cells and antigen recognition -- The role of natural killer T cells in tumor immunity -- Immunomodulatory molecules of the immune system -- HLA class I antigen abnormalities in tumors -- The local tumor microenvironment -- Tumor vaccines -- Peptide and protein vaccines for cancer -- DNA vaccines against cancer -- Recombinant viral and bacterial vaccines -- Dendritic cell vaccines -- Whole cell vaccines -- Carbohydrate vaccines against cancer -- Passive immunotherapy approaches -- Monoclonal antibody therapy of cancer -- Adoptive cellular therapy for the treatment of cancer -- Checkpoint blockade and combinatorial immunotherapies -- Clinical tumor immunotherapy -- General approaches to measuring immune responses -- Interferon therapy -- High dose interleuken-2 therapy -- Monoclonal antibodies in cancer therapy -- Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy.
  • This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
  • Genetic recombination in cancer 2003, ScienceDirect
  • Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
  • Genetics for surgeons 2005, NCBI Bookshelf
  • Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.
  • Geocoding health data 2008, CRCnetBASE
  • Geriatric oncology 2009, Springer
    Aging and cancer, what oncologists need to know / Arti Hurria, Lodovico Balducci -- Assessing the older cancer patient / Melissa Cohen, David Reuben, Arash Naeim -- Cancer screening in older adults / Louise C. Walter -- Physiological consequences of aging / Bindu Kanapuru, William B. Ershler -- Assessment and impact of comorbidity in older adults with cancer / Athanasios Karampeasiz, Martine Extermann -- Geriatric syndromes defined and explained for oncology practice / Miriam B. Rodin -- Family caregivers / Betty R. Ferrell, Polly Mazanec -- Surgical management of the older patient with cancer / David M. Heimann, M. Margaret Kemeny -- Chemotherapy for the older adult with cancer / Supriya Mohile, Nail Nagovskiy, Lodovico Balducci -- Radiation therapy in geriatric oncology / Sarah E. Hoffe, Mark S. Russell -- Palliative care, special considerations for older adults with cancer / Genevieve N. Thompson, Harvey M. Chochinov.
  • Glioblastoma 2010, Springer
  • Glioma 2012, Springer
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
  • Glioma signaling 2013, Springer
  • Gliomas 2009, Springer
    Part I. Gliomas -- Astrocytic tumors / Markus J. Riemenschneider and Guido Reifenberger -- Molecular pathology of oligodendroglial tumors / Christian Hartmann and Andreas von Deimling -- Ependymal tumors / Martin Hasselblatt -- Pediatric gliomas / Stefan Pfister and Olaf Witt -- Hereditary tumor syndromes and gliomas / David Reuss and Andreas von Deimling -- Part II. Management of gliomas -- Surgical management of intracranial gliomas / Matthias Simon and Johannes Schramm -- Radiation therapy / Stephanie E. Combs -- Adjuvant therapy / Wolfgang Wick and Michael Weller -- Other experimental therapies for glioma / Manfred Westphal and Katrin Lamszus -- Neurotoxicity of treatment / Pasquale Calabrese and Uwe Schlegel -- Neuroimaging / R. Klingebiel and G. Bohner -- Part III. Angiogenesis in gliomas / Marcia Machein and Lourdes Sánchez de Miguel -- Gene regulation by methylation / Wolf C. Mueller and Andreas von Deimling -- Brain tumor stem cells / Christian Nern, Daniel Sommerlad, Till Acker and Karl H. Plate.
  • Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes. Aids the development of therapeutic treatments for cancer. Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research.
  • Regulation of tumor initiation and metastatic progression by eph receptor tyrosine kinases / Jin Chen -- Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis / Ombretta Salvucci, Giovanna Tosato -- Semaphorin signals tweaking the tumor microenvironment / Claudia Muratori, Luca Tamagnone -- Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors / Christian Gespach -- Roundabout way to cancer / Mimmi S. Ballard, Lindsay Hinck -- Role of the VEGF/VEGFR axis in cancer biology and therapy.
  • This study (EGF104911) is designed to evaluate the efficacy and safety of lapatinib in patients with advanced or metastatic breast cancer. Eligible subjects must have ErbB2 overexpressing tumors and are refractory to treatment with anthracycline, taxanes and trastuzumab containing regimens. The study data obtained from EGF104911 will be combined with the data from EGF100642 and integrated analysis will be carried out in order to enhance the credibility of the study results.
  • Gynecologic cancer 2006, Springer
    Multidisciplinary care of patients with gynecologic cancers / David M. Gershenson ... [et al.] -- Prevention and early detection of endometrial and ovarian cancers / Karen H. Lu -- Preinvasive disease of the lower genital tract / Andrea Milbourne -- Selected topics in gynecologic pathology / Anais Malpica, Michael T. Deavers, and Elvio G. Silva -- Imaging of gynecologic malignancies / Revathy Iyer -- Contemporary treatment of vaginal and vulvar cancers / Patricia J. Eifel and Thomas W. Burke -- Treatment of early cervical cancer / Charles F. Levenback -- Treatment of locally advanced cervical cancer / Anuja Jhingran, Patricia J. Eifel, and Pedro T. Ramirez -- Uterine sarcomas / Lois M. Ramondetta ... [et al.] -- Treatment of endometrial cancer / Lois M. Ramondetta ... [et al.] -- Surgery for ovarian cancer / Judith K. Wolf and J. Taylor Wharton -- Chemotherapy for epithelial ovarian cancer / Michele L. Donato ... [et al.] -- Treatment of rare ovarian malignancies / Jubilee Brown and David M. Gershenson -- Gestational trophoblastic disease / Hui T. See ... [et al.] -- Fertility-sparing options for treatment of women with gynecologic cancers / Pedro T. Ramirez -- Quality of life and sexual functioning / Diane C. Bodurka and Charlotte C. Sun -- Palliative care for gynecologic malignancies / Florian Strasser, Michael W. Bevers, and Eduardo Bruera.
  • Gynecological imaging 2013, Springer
    This book provides a detailed guide to the use and interpretation of color Doppler ultrasound, CT, and MR imaging in patients with gynecological disorders. The advantages and limitations of each modality in imaging different pathologies are clearly presented, and advice is provided on the most appropriate option when ultrasound does not permit a definite diagnosis or fails to determine the precise extension of a lesion. Throughout, emphasis is placed on the importance of microscopic and macroscopic findings for a full understanding of the radiological appearances, and relevant points from the basic sciences are also highlighted. Special attention is paid to issues of differential diagnosis and imaging results that are characteristic of a particular type of lesion. The authors are recognized experts in the field who draw upon their considerable experience to provide an up-to-date reference book highly relevant to everyday clinical practice.
  • There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.
  • Biologic and pharmacologic basis of cancer chemotherapy and biotherapy / Roland T. Skeel and Samir N. Khleif -- Systemic assessment of the patient with cancer and long-term consequences of treatment / Roland T. Skeel -- Selection of treatment for the patient with cancer / Roland T. Skeel -- Antineoplastic drugs and biologic response modifiers : classification, use, and toxicity of clinically useful agents / Roland T. Skeel -- High-dose chemotherapy and hematopoietic stem cell transplantation in hematologic malignancies / Roberto Rodriguez and Chatchada Karanes -- Carcinomas of the head and neck / Harlan A. Pinto -- Carcinoma of the lung / Sophie Sun and Joan H. Schiller -- Carcinomas of the gastrointestinal tract / Al B. Benson, III -- Carcinomas of the pancreas, liver, gallbladder, and bile ducts / Rekha T. Chaudhary -- Carcinoma of the breast / Iman Mohamed -- Gynecologic cancer / Stephen Andrews -- Urologic and male genital cancers / Joseph S. Chan, Scott B. Saxman, and Craig R. Nichols -- Kidney cancer / Walter D. Y. Quan, Jr. and Mikhail Vinogradov -- Thyroid and adrenal carcinomas / Haitham S. Abu-Lebdeh and Samir N. Khleif -- Melanomas and other skin malignancies / Karen S. Milligan and Walter D. Y. Quan, Jr. -- Primary and metastatic brain tumors / April F. Eichler and Tracy T. Batchelor -- Soft tissue sarcomas / Robert S. Benjamin --Bone sarcomas / Robert S. Benjamin -- Acute leukemias / Olga Frankfurt and Martin S. Tallman -- Chronic leukemias / Peter White and Paul R. Walker -- Myeloproliferative diseases and myelodysplastic syndromes / Peter White and Paul R. Walker -- Hodgkin's lymphoma / Richard S. Stein and David S. Morgan -- Non-Hodgkin's lymphoma / Richard S. Stein and John P. Greer -- Multiple myeloma, other plasma cell disorders , and primary amyloidosis / Rachid Baz and Mohamad A. Hussein -- Metastatic cancer of unknown origin / James M. Leonardo -- Human immunodeficiency virus / Mary E. Cianfrocca -- Side effects of cancer chemotherapy / Janelle M. Tipton -- Infections : etiology, treatment, and prevention / Joan M. Duggan -- Transfusion therapy, bleeding, and clotting / Mary R. Smith and NurJehan Quraishy -- Oncology emergencies and critical care issues, anaphylaxis, spinal cord compression, cerebral edema, superior vena cava syndrome, hypercalcemia, tumor lysis syndrome, and respiratory failure / Roland T. Skeel -- Malignant pleural, peritoneal, and pericardial effusions and meningeal infiltrates / Rekha T. Chaudhary -- Cancer pain / Michael J. Fisch and Charles S. Cleeland -- Emotional and psychiatric problems in patients with cancer / Kathleen S. N. Franco-Bronson and Kristi S. Williams.
  • SECTION I: BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY AND MOLECULAR THERAPY -- 1. Biologic and pharmacologic basis of cancer chemotherapy / Roland T. Skeel -- 2. Biologic basis of molecular targeted therapy / Osama E. Rahma, Samir N. Khleif -- 3. Systemic assessment of the patient with cancer and consequences of treatment / Roland T. Skeel -- 4. Selection of treatment with the patient with cancer / Roland T. Skeel -- SECTION II: CHEMOTHERAPY AND MOLECULAR THERAPY OF HUMAN CANCER -- 5. Carcinonas of the head and neck / Barbara A. Murphy -- 6. Carcinomas of the lung / David E. Gerber, Joan H. Schiller -- 7. Carcinomas of the gastrointestinal tract / Maxwell Vergo, AI B. Benson III -- 8. Carcinomas of the pancreas, liver, gallbladder, and bile ducts / Timothy J. Kennedy, Steven K. Libutti -- 9. Carcinomas of the breast / Patrick Glyn Morris, Clifford A. Hudis -- 10. Gynecologic cancer / Thomas McNally, Richard T. Penson, Chau Tran, Michael J. Birrer -- 11. Urologic and male genital cancers / Brendan D. Curti, Craig R. Nichols -- 12. Kidney cancer / Mark T. Andolina, Colleen Darnell, Olivier Rixe -- 13. Thyroid and adrenal cancinomas / Haitham S. Abu-Lebdeh, Michael E. Menefee, Keith C. Bible -- 14. Melanomas and other cutaneous malignancies / Ragini Kudchadkar, Jeffrey S. Weber -- 15. Primary and metastatic brain tumors / April Fitzsimmons Eichler, Tracy T. Batchelor -- 16. Soft tissue sarcomas / Robert S. Benjamin -- 17. Bone sarcomas / Robert S. Benjamin -- 18. Acute leukemias / Olga Frankfurt, Martin S. Tallman -- 19. Chronic leukemias / Khaled el-Shami, Bruce D. Cheson -- 20. Myeloproliferative neoplasms and myledysplastic syndromes / Elias Jabbour, Hagop Kantarjian -- 21. Hodgkin lymphoma / Richard S. Stein, David S. Morgan -- 22. Non-Hodgkin lymphoma / Mark Roschewski, Wyndham H. Wilson -- 23. Multiple myeloma, other plasma cell disorders, and primary amyloidosis / Rachid Baz, Mohamad A. Hussein -- 24. Metastatic cancer of unknown origin / James M. Leonardo -- 25. HIV-associated malignancies / Thomas S. Uldrick, Mark N. Polizzotto, Robert Yarchoan -- SECTION III: SUPPORTIVE CARE OF PATIENTS WITH CANCER -- 26. Side effects of chemotherapy and molecular targeted therapy / Janelle M. Tipton -- 27. Infections: etiology, treatment, and prevention / Thomas J. Walsh, Joan M. Duggan -- 28. Transfusion therapy, bleeding, and clotting / Mary R. Smith, NurJehan Quraishy -- 29. Oncology emergencies and critical care issues: spinal cord compression, cerebral edema, Superior Vena Cava Syndrome, anaphylaxis, respiratory failure, Tumor Lysis Syndrome, hypercalcemia, and bone metastasis / Roland T. Skeel -- 30. Malignant pleural, peritoneal, and pericardial effusions and meningeal infiltrates / Rekha T. Chaudhary -- 31. Cancer pain / Richard T. Lee, Michael J. Fisch -- 32. Emotional and psychiatric problems in patients with cancer / Kristi Skeel Williams, Kathleen S.N. Franco-Bronson -- SECTION IV: CHEMOTHERAPEUTIC AND MOLECULAR TARGETED AGENTS AND THEIR USE -- 33. Classification, use, and toxicity of clinically useful chemocherapy and molecular targeted therapy / Roland T. Skeel -- Appendix A: Nomogram for determining body surface area of adults from height and mass -- Appendix B: Nomogram for determining boy surface area of children from height and mass.
  • Part I: --Burden --Cancer survivorship: a bird's eye view from an insider /Michael Feuerstein --The burden of cancer survivorship: a pandemic of treatment success /Steven N. Wolff --Quality of care /Craig C. Earle --Quality of life in long-term cancer survivors /Joan Bloom, Soo H. Kang, Dana M. Petersen, and Susan L. Stewart --Health care disparities /Salewa Oseni and Ismail Jatoi --Measuring quality of life in cancer survivors /David Victorson, David Cella, Lynne Wagner, Laura Kramer, and Mary Lou Smith --Part II: --Common problems --Exercise motivation and behavior change /Kerry S. Corneya, Kristina H. Karvinen, and Jeffrey K.H. Vallance --Fatigue /Alexander V. Ng, Carlynn A. Alt, and Elizabeth M. Gore --Pain /Victor T. Chang and Ryuichi Sekine --Depression /Peter C. Trask and Timothy Pearman --Interpersonal relationships /Andrea A. Thorton and Martin A. Perez --Adaptation in the face of advanced cancer /Carissa A. Low, Tammy Beran, and Annette L. Stanton --Part III: --Secondary prevention --Restoring emotional well-being: a model /Robert W. Lent --Physical activity for cancer survivors: potential benefits and guidelines /Clare Stevinson, Kristin L. Campbell, Christopher M. Sellar, and Kerry S. Courneya --Nutrition and weight management in cancer survivors /Virginia Uhley and K. L. Catherine Jen --Management of chemotherapy related cognitive dysfunction /Robert J. Ferguson, Raine Riggs, Tim Ahles, and Andrew J. Saykin --Smoking cessation and cancer survivors /Jamie S. Ostroff and Lara K. Dhingra --Psychological distress, depression, and anxiety /Arthur M. Nezu and Christine Maguth Nezu --Managing daily and long-term stress /Linda E. Carlson and Michael Speca --Pain and function: a psychosocial perspective /Michael J.L. Sullivan, Pascal Thibault, Andre Savard, and Ana Velly --Work /Jos Vebeek and Evelien Spelten --Comprehensive long-term follow-up: cancer survivorship centers /Linda A. Jacobs, Jane Alavi, Angela DeMichele, Steven Palmer, Carrie Stricher, and David Vaughn --Part IV: --Survivor and provider perspectives --Survivor perspectives on quality care /Kathryn McPherson and Rod MacLeod --Living with advanced cancer /Sheila Payne --Part V: --International perspective --Global considerations /Patricia A. Findley --Part VI: --Future directions --Cancer survivorship: research, practice, and policy /Michael Feuerstein.
  • Introduction to Cutaneous Melanoma --Clinical Features and Classification --Diagnosis, Staging, and Follow-up --Treatment of Primary Tumor and Locoregional Disease --Treatment of Distant and Irresectable Metastatic Disease --Emerging Therapies and Combination Approaches.
  • Skin cancer -- Central nervous system -- Malignant and benign diseases of the eye and orbit -- Cancer of the ear -- Nasopharyngeal cancer -- Nasal cavity and paranasal sinus cancer -- Oropharyngeal cancer -- Cancer of the lip and oral cavity -- Larynx and hypopharynx cancer -- Salivary gland tumors -- Thyroid cancer -- Unusual neoplasms of the head and neck -- Management of the neck and unknown primary of the head and neck -- Small cell lung cancer -- Non-small cell lung cancer -- Mesothelioma and thymic tumors -- Breast cancer -- Esophageal cancer -- Gastric cancer -- Pancreatic cancer -- Hepatobiliary cancer -- Colorectal cancer -- Anal cancer -- Renal call carcinoma -- Bladder cancer -- Prostate cancer -- Cancer of the penis -- Testicular cancer -- Cervical cancer -- Endometrial cancer -- Ovarian cancer -- Vaginal cancer -- Vulvar cancer -- Urethral cancer -- Hodgkin's lymphoma -- Non-Hodgkin's lymphoma -- Cutaneous lymphomas -- Multiple myeloma and plasmacytoma -- Bone tumors -- Soft-tissue sarcoma -- Pediatric (Non-CNS) tumors -- Palliation and benign conditions -- Clinical radiobiology and physics.
  • v. 1. Molecular genetics; Lung and breast carcinomas -- v. 2. Molecular pathology; Colorectal carcinoma and prostate carcinoma -- v. 3. Molecular genetics; Liver carcinoma and pancreatic carcinoma -- v. 4. Molecular genetics; Gastrointestinal carcinoma and ovarian carcinoma.
  • Pt. 1. Phase I trials -- pt. 2. Phase II trials -- pt. 3. Phase III trials -- pt. 4. Exploratory and high -dimensional data analyses.
  • 1. Overview : therapeutic biomarkers in cancer / Sherry X. Yang and Janet E. Dancey -- 2. Statistical considerations in the development and evaluation of therapeutic biomarkers in cancer / Lisa M. McShane, Edward L. Korn, and Boris Freidlin -- 3. Role of biomarkers in clinical development of cancer therapies / Helen X. Chen -- 4. HER-2 as a prognostic and predictive biomarker in cancer / Suparna B. Wedam and Stanley Lipkowitz -- 5. Hormone receptors and endocrine therapy in breast cancer / Sherry X. Yang -- 6. Predictive biomarkers for epidermal growth factor receptor agents in non-small cell lung cancer / John Hilton, Penelope A. Bradbury, and Janet Dancey -- 7. Markers of sensitivity and resistance to EGFR inhibitors in colorectal cancer / Jose G. Monzon and Janet Dancey -- 8. Targeting BCR-ABL for molecular therapy of chronic myelogenous leukemia / Shamudheen Rafiyath, Guoqing Wei, and Delong Liu -- 9. Gastrointestinal stromal tumors : from molecular pathogenesis to therapy / Joaquina Baranda, Rashna Madan, and Andrew K. Godwin -- 10. PML/RARa fusion gene and response to retinoic acid and arsenic trioxide treatment / Alicja M. Gruszka and Myriam Alcalay -- 11. Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity -- 12. UGT1A1 polymorphisms and mutations lead to irinotecan-induced toxicity / K.M. Reece and W.D. Figg -- 13. The 21-gene recurrence score and benefit of chemotherapy in estrogen receptor-positive breast cancer / Petra Rietschel and Joseph A. Sparano -- 14. Mammaprint for individualized recurrence risk assessment and treatment recommendations for early-stage breast cancer patients / Sonal J. Desai and Tianhong Li -- 15. BRCA mutation and PARP inhibitors / Marcie K. Weil ... [et al.] -- 16. EML4-ALK fusion gene and therapy with ALK-targeted agents in non-small cell lung cancer / Vimal Patel and Biren Saraiya -- 17. BRAF-targeted therapy in metastatic melanoma / Noori Kim and April Deng.
  • Head & neck cancer 2013, Springer
    This book is a collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals, and is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book. This volume covers Head and Neck cancer in such a way that it covers the ancient history of these tumors to modern diagnostic methods. It covers the various aspects of treatment and the healing of the these patients. Various aspects of molecular biology, the histology, and diagnostic methods are also discussed. Links are made between subject matter that will give readers new insight to these tumors. This volume will give a broad understanding to the various aspects related to Head and Neck cancer in general, and will provide the foundation for anyone to explore the subject matter in greater detail.
  • Head and neck cancer 2011, Springer
    Epidemiology and Aetiology of Head and Neck Cancers -- Head and Neck Cancer Prevention -- Cellular and Molecular Pathology of Head and Neck Tumors -- Oncogenomics/Proteomics of Head and Neck Cancers -- Genetics and Epigenetics of Head and Neck Cancer -- Immunology of Head and Neck Cancer -- HPV and EBV in Head and Neck Cancer -- Head and Neck Cancer Staging and Prognosis: Perspectives of the UICC and the AJCC -- Biomarkers in Head and Neck Cancer -- Hypoxia in Head and Neck Cancers: Clinical Relevance and Treatment -- Translational Research in Head and Neck Oncology -- Preclinical Models of Head and Neck Squamous Cell Carcinoma -- Morphologic Investigations in Head and Neck Cancer -- Ultrasound Investigations in Head and Neck Cancer Patients -- Functional Imaging -- Sentinel Node Biopsy for Head and Neck Cancer -- Approaches to Supportive Care -- Intensity-Modulated Radiation Therapy for Head and Neck Cancer -- Principles of Systemic Chemotherapy for Squamous Cell Head and Neck Cancer -- Molecular Targeted Therapies in Head and Neck Cancer -- Phase I Study Methodology in Head and Neck Oncology -- Evidence-Based Head and Neck Oncology: Principles and Pitfalls -- Programs of Organ and Function Preservation -- Multidisciplinary Approach of Unresectable Head and Neck Cancer -- Laser Endoscopic Treatment -- Multidisciplinary Management of Skull Base and Superstructure Tumors.Multidisciplinary Management of Oral Cavity and Maxillary Sinus Cancers -- Cancers of the Larynx: Tis, T1, T2 Evaluation and Management -- Multidisciplinary Management of Oropharynx Carcinomas -- Multidisciplinary Management of Hypopharyngeal Carcinoma -- Cancers of the Larynx: Tis, T1, T2 Evaluation and Management -- Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers -- Principles and New Approaches in Surgical Reconstruction -- Multidisciplinary Treatment of the Neck -- Postoperative Management of High-Risk Resectable Head and Neck Cancer -- Management of Salivary Gland Cancer -- Head and Neck Melanoma -- Cervical Lymph Node Metastases of Squamous Cell Carcinoma from an Unknown Primary Site -- Management of Thyroid and Parathyroid Cancers -- Head and Neck Paragangliomas --Treatment of the Elderly Head and Neck Cancer Patient -- Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity -- Proton Beam Therapy for Head and Neck Cancer -- Normal Tissue Complications and Protection in Head and Neck Cancer Patients -- Rehabilitation of Heavily Treated Head and Neck Cancer Patients -- Salvage Therapy in Head and Neck Cancer Patients -- Systemic Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck -- Best Supportive Care for Palliative Treatment -- Quality of Life in Head and Neck Cancer Patients -- Quality Assurance of Clinical Trials in the Management of Cancer in the Head and Neck.
  • Head and neck cancer 2003, ScienceDirect
  • General principles of head and neck pathology -- Clinical evaluation of the head and neck cancer patient -- Prognostic factors in patients with head and neck cancer -- Radiologic evaluation of the head and neck cancer patient -- Novel radiation therapy techniques in the management of head and neck cancer -- New approaches: robotics and endoscopic head and neck surgery -- Targeted agents in squamous cell carcinoma of the head and neck -- Multidisciplinary reconstruction of the head and neck: general principles -- Dental oncology and maxillofacial prosthetics -- Interdisciplinary symptom management -- Evaluation and rehabilitation of speech, voice, and swallowing functions after treatment of head and neck cancer -- Human papillomavirus -- associated head and neck carcinoma -- Chemoprevention -- Management of the neck -- Metastatic cancer to the neck from an unknown primary site -- Cancer of the oral cavity -- Cancer of the oropharynx -- Cancer of the larynx -- Cancers of the hypopharynx and cervical esophagus -- Cancer of the nasal vestibule, nasal cavity paranasal sinuses, anterior skull base, and orbit: surgical management -- Cancer of the nasal cavity and paranasal sinus: radiation therapy and chemotherapy management -- Cancer of the nasopharynx -- Basal and squamous cell skin cancers -- Melanoma of the head and neck -- Management of salivary gland tumors -- Primary and recurrent disease of the lateral skull base -- Paragangliomas of the head and neck -- Cancer of the thyroid and parathyroid -- Soft tissue and bone sarcomas of the head and neck -- Systemic targeted therapy for recurrent and metastatic head and neck squamous cell cancer.
  • "Part of the popular Foundations in Diagnostic Pathology Series, Head and Neck Pathology delivers vital diagnostic guidance in a compact, high-yield format. Concise and easy to use, this pathology reference offers a practical, well-organized approach to evaluating a wide range of specimens in both head and neck and related endocrine pathology. Easily review normal histology before examining abnormal findings so you can avoid false positives. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Apply the latest diagnostic criteria for all of the most commonly seen neoplastic and non-neoplastic conditions of the larynx, hypopharynx, and trachea; nasal cavity, paranasal sinuses, and nasopharynx; oral cavity and oropharynx; salivary glands; ear; and temporal bone. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Quickly reference key information with convenient, at-a-glance clinical and pathologic boxes throughout."--Summary of the editor.
  • Specific Challenges in Optimizing Health Care for Cancer Survivors -- What Is Quality Health Care for Cancer Survivors? -- Managing Symptoms over Time -- Health Behaviors and Wellness -- Rehabilitation in the Context of Cancer Survivorship -- Long-Term Psychological Well-Being: Strategies for Assessment and Intervention -- Disparities in Care for Cancer Survivors -- Cancer Survivorship Plans: A Paradigm Shift in the Delivery of Quality Cancer Care -- Optimizing Health: Primary Care -- Optimizing Health: Oncology Care -- Optimizing Survivorship Care: Academic and Community Clinic Models -- The Final Phase of Cancer Survivorship: End-of-Life Care -- Building a Critical Mass of Health-Care Providers, Administrators, and Services for Cancer Survivors -- Epidemiology of Cancer Recurrence, Second Primary Cancer, and Comorbidity Among Cancer Survivors -- Health Economics and Cancer Survivorship -- Human Factors Engineering: Targeting Systems for Change -- Cancer Survivorship and National Health Reform -- Quality Health Care for Cancer Survivors.
  • The Nature of cancer and its psychosocial challenges -- Why work with couples? -- Assessing the couple's adjustment to cancer -- Integrating tasks of illness into the couple's daily routine -- Building cognitive coping skills -- Communicating support -- Expanding the couple's coping skills -- Enhancing sexuality and body image -- Helping children to cope when a mother has cancer -- Living with cancer after treatment ends.
  • Hematologic cancers 2012, Springer
    B Cell Growth, Differentiation and Malignancies / Jianguo Tao and Chih-Chi Andrew Hu -- Follicular Lymphoma: Recent Advances / Alyssa Bouska, SharathKumar Bagvati, Javeed Iqbal, Basem M. William and Wing C. Chan -- Chronic Lymphocytic Leukemia: From Pathobiology to Targeted Therapy / Javier Pinilla-Ibarz and Chih-Chi Andrew Hu -- Genetic and Environmental Determinants in Multiple Myeloma: Implications for Therapy / Kenneth H. Shain and William S. Dalton -- EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly / Jorge J. Castillo -- HIV and Lymphoma / Lubomir Sokol and Brady E. Betran -- Molecular Biology of Mantle Cell Lymphoma / Bijal Shah, Peter Martin, Jianguo Tao and Eduardo M. Sotomayor -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Inflammatory, Autoimmune or Immunologic Disorders / Ling Zhang and Jianguo Tao -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Infection Diseases / Ling Zhang and Roger Klein -- Hodgkin Lymphoma: From Molecular Pathogenesis to Targeted Therapy / Ádám Jóna, Árpád Illés and Anas Younes -- Myelodysplastic Syndromes / Grant E. Nybakken and Adam Bagg -- Chronic Myeloproliferative Disorders:From Molecular Pathogenesis to Targeted Therapy / Richard A. Walgren and Josef Prchal -- Chronic Myeloid Leukemia / Kapil Bhalla, Celalettin Ustun and Warren Fiskus -- Novel Targeted Therapeutics for Acute Myeloid Leukemia / Vu Duong and Jeffrey Lancet -- Novel Targeted Therapeutics for Peripheral T-Cell Lymphoma / Owen O. Connor, Salvia Jain and Jasmine Zain -- Large Granular Lymphocyte Leukemia - From Molecular Pathogenesis to Targeted Therapy / Mithun Vinod Shah and Thomas P. Loughran Jr. -- Epigenetic Regulation and Therapy in Lymphoid Malignancies / Yizhuo Zhang, Shanqi Guo and Haifeng Zhao.
  • Hematologic malignancies 2007, Springer
  • Part 1. Background: Biology, Physiology and Pharmacology -- Part 2. The Colony-Stimulating Factors -- Part 3. The Erythroid-Stimulating Agents -- Part 4. The Thrombopoietic Agents -- Part 5. Special Considerations.
  • Anatomy -- Surgical instrument and dissection technique -- Surgical procedures -- Approaches to the caudate lobe -- Classification of caudate lobe resection -- Retrograde resection of caudate lobe -- Measures for safe resection of caudate lobe -- Laparoscopic resection of the caudate lobe.
  • Hepatocellular carcinoma 2011, Springer
    Epidemiology and pathogenesis of hepatocellular carcinoma -- Biology of hepatocellular carcinoma -- Hepatocellular cancer: pathologic considerations -- Screening program in high-risk populations -- Staging of hepatocellular carcinoma -- Multidisciplinary care of the hepatocellular carcinoma patient -- Evidence-based guidelines for treatment of hepatocellular carcinoma in Japan -- Hepatocellular carcinoma arising in the non-viral, non-alcoholic liver -- Liver resection for hepatocellular carcinoma -- Ultrasound-guided liver resection for hepatocellular carcinoma -- Portal vein embolization prior to resection -- Laparoscopic liver resection for HCC: a European perspective -- Laparoscopic liver surgery for the management of hepatocellular carcinoma: the American perspective -- Liver transplant for hepatocellular carcinoma -- Vascular resection for hepatocellular carcinoma -- Radiofrequency ablation for hepatocellular carcinoma -- Microwave ablation and hepatocellular carcinoma -- Transarterial chemoembolization -- Chemoembolization with drug-eluting beads -- Yttrium-90 radioembolotherapy for hepatocellular carcinoma -- Cytotoxic chemotherapy and endocrine therapy for hepatocellular carcinoma -- Targeted therapies for hepatocellular carcinoma -- The future: combination systemic therapy for hepatocellular carcinoma -- Follow-up and salvage therapy for recurrent hepatocellular carcinoma.
  • Epidemiology of hepatocellular carcinoma -- Environmental carcinogens and risk for human liver cancer -- Primary liver cancer: chemical carcinogenesis -- Molecular mechanisms of hepatocellular carcinoma: insights to therapy -- Genomic profiling of human hepatocellular carcinoma -- Pathologic aspects of hepatocellular tumors -- Hepatocellular carcinoma associated with hepatitis B virus -- Hepatitis C and hepatocellular carcinoma -- Metabolic disease and hepatocellular carcinoma -- Clinical features and a clinician's diagnostic approach to hepatocellular carcinoma -- Screening and biomarkers for hepatocellular carcinoma -- Use of imaging techniques to screen for hepatocellular carcinoma -- MRI for detection and evaluation of hepatocellular carcinoma -- Ultrasound of hepatocellular carcinoma: the important contribution of contrast enhancement -- Percutaneous ethanol injection -- Radiofrequency ablation of hepatocellular carcinoma -- Resection of hepatocellular carcinoma -- Liver transplantation for hepatocellular carcinoma -- Living donor liver transplantation for hepatocellular carcinoma -- Medical therapy of HCC -- Percutaneous interventional technique for intra-arterial chemoembolization -- Molecular targeted therapies for HCC -- Radiation therapy for hepatocellular carcinoma -- Psychosocial issues in hepatocellular carcinoma -- Putting it all together.
  • Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6percent, however patients with a familial risk (with two or more first or second degree relatives) make up 20percent of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
  • High-grade gliomas 2007, Springer
    Histologic classification of high-grade gliomas / Richard A. Prayson -- Molecular classifications / Gregory N. Fuller-- Pediatric high-grade glioma / Bruce H. Cohen -- Adult high-grade glioma / Nicholas Butowski, Susan Chang -- Computerized tomography / Manzoor Ahmed, Thomas J. Masaryk -- Magnetic resonance imaging / Paul M. Ruggieri -- Magnetic resonance spectroscopy / G. Evren Keles, Soonmee Cha, Mitchell S. Berger -- Imaging tumor biology: physiological and molecular insights / Timothy P. L. Roberts, Andrea Kassner -- Nuclear imaging of gliomas / Alexander M. Spence ... [et al.] -- Magnetoencephalography / Michael P. Steinmetz, Jurgen Luders, Edward C. Benzel -- General considerations / Glen H. J. Stevens -- Surgical techniques / Gene H. Barnett -- Radiation therapy / Hiral K. Shah, Minesh P. Mehta -- Brachytherapy / Marcus L. Ware, P. K. Sneed, Michael W. McDermot -- Radiosurgery / John H. Suh, Gene H. Barnett -- Chemotherapy / Manmeet Singh Ahluwalia, David M. Peereboom -- Nursing considerations / Kathleen Lupica, Gail Ditz -- Convection-enhanced delivery / Andrew A. Kanner -- Immunotoxins for glioma therapy / Syed Rafat Husain, Raj K. Puri -- Small molecule agents / Michael Vogelbaum, Tina Thomas -- Cytokine immuno-gene therapy for malignant brain tumors / Roberta P. Glick ... [et al.] -- Monoclonal antibodies / Abraham Boskovitz ... [et al.] -- Clinical trials of oncolytic viruses for gliomas / E. Antonio Chiocca, M. L. Lamfers -- Biological modifiers / Alexander Mason, Steven Toms, Aleck Hercbergs -- Gene therapy / Maciej S. Lesniak, Alessandro Olivi -- Boron neutron capture therapy of brain tumors: current status and future prospects / Rolf F. Barth ... [et al.] -- Photodynamic therapy / Bhadrakant Kavar, Andrew H. Kaye.
  • Hilar Cholangiocarcinoma 2013, Springer
    This is a multi-author book on hilar cholangiocarcinoma, written by an international team of world-renowned experts covering topics in their respective areas of expertise. There are altogether 71 authors from 14 countries/regions, mainly Argentina, Australia, China, Germany, Italy, Japan, Korea, Malaysia, Thailand, the Netherlands, the United Kingdom and the United States of America.This book aims to provide an up-to-date, fully referenced text that is as succinct as possible, but as comprehensive as necessary, addressing all topics in hilar cholangiocarcinoma.
  • The histopathologic interpretation of melanocytic neoplasms is probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions that histopathologists might encounter. Each case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist both general pathologists and dermatopathologists in making an accurate diagnosis applicable to their daily practice, and one that can be understood by clinicians. They achieve this by providing criteria that can serve as a sound basis for an unequivocal diagnosis in most cases. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
  • Histone code and beyond 2006, Springer
  • Histone deacetylases 2011, Springer
    K-acetylation and its enzymes: overview and new developments / Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang.-- Biology of HDAC in cancer: the nuclear and epigenetic components / Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayer, Christian Seiser.-- Deacetylation of nonhistone proteins by HDACs and the implications in cancer / Lirong Peng, Edward Seto.-- Biology and therapeutic implications of HDACs in the heart / Timothy A. McKinsey.-- HDACs in skeletal muscle remodeling and neuromuscular disease / Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao.-- Rationale for HDAC inhibitor therapy in autoimmunity and trasplantation / Wayne W. Hancock.-- Role of mammalian sirtuins in the regulation of metabolism, aging, and longevity / Akiko Satoh, Liana Stein, Shin Imai.-- Mictochondrial sirtuins in the regulation of mictochondrial activity and metabolic adaption / David B. Lombard, Daniel X. Tishkoff, Jianjun Bao.-- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance / Debra Toiber, Carlos Sebastian, Raul Mostoslavsky.-- Structural biology of human netal-dependent histone deacetylases / Matthieu Schapira.-- Sirtuin modulators / Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov.
  • Histone deacetylases 2006, Springer
    Histone deacetylase 1 / Dominique Meunier and Christian Seiser -- Biochemistry of multiprotein HDAC complexes / Alejandro Vaquero, Michael Scher, and Danny Reinberg -- The biology of HDAC3 / Edward Seto -- The biology of HDAC8, a unique class I histone deacetylase / David Waltregny and Vincent Castronovo -- Regulation of muscle gene expression by histone deacetylases / Timothy A. McKinsey and Eric N. Olson -- The class IIA histone deacetylases: functions and regulation / Herbert G. Kasler and Eric Verdin -- Histone deacetylases in the response to misfolded proteins / J. Andrew McKee and Tso-Pang Yao -- Evolution of sirtuins from archaea to vertebrates / Roy A. Frye -- Structure of the Sir2 family of NAD+-dependent histone/protein deacetylases / Kehao Zhao and Ronen Marmorstein -- The enzymology of Sir2 proteins / Margie T. Borra and John M. Denu -- The class III protein deacetylases: homologs of yeast Sir2P / Bjoern Schwer ... [et al.] -- HDAC inhibitors: discovery, development, and clinical impacts / Akihiro Ito, Norikazu Nishino, and Mitsuaki Yoshida -- Cell cycle targets of histone deacetylase inhibitors / Brian Gabrielli -- HDAC inhibitors: an emerging anticancer therapeutic strategy / Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja.
  • This bookprovides an easily comprehensible and practicable framework for standardised histopathology reports in surgical cancer. It details the gross description, histological classification, tumor differentiation, extent of local tumor spread, involvement of lymphovascular channels, lymph nodes and excision margins of the common carcinomas and also summarises non-carcinomatous malignancies. The 7th edition TNM and WHO classifications of cancers are incorporated, with comments on any associated pathology, diagnostic clues and prognostic criteria. Staging information is supplemented visually by line diagrams. Each chapter has a more formal introductory paragraph than in the previous edition,giving epidemiological, clinical, investigative and treatment summary details, and chapter references are updated; specimen type notes new clinical procedures. Other pathology includes updated immunophenotypic expression with use of newantibodies and molecular techniques. The impact of these ancillary investigations on diagnosis, and as biomarkers of prognosis and prediction of response to treatment is summarised. The effect of adjuvant treatments on cancers is also noted. Experience based clues are given throughout as aids to tumor typing, grading, staging and gauging prognosis and response to treatment. The key information in this book equips the pathologist to produce high quality, clinically appropriate histopathology reports, and to participate in contemporary multidisciplinary team management of patients with surgical cancer. Histopathology Reporting: Guidelines for Surgical Cancer, Third Edition is invaluable for trainee and consultant diagnostic histopathologists all over the world.
  • Hodgkin lymphoma 2011, Springer
  • Household Use of Solid Fuels -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- High-temperature Frying -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
  • HPV and cancer 2012, Springer
    "HPV and Cancer" is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes.
  • HPV and cervical cancer 2012, Springer
    Infection and Cervical Cancer: An Old Fact with a Recent Solution /Lutz Gissman --Human Papillomavirus: Natural History of a Viral Infection in the Genesis of a Cancer /Franco Borruto and Ciro Comparetto --The Immunobiology of Human Papillomavirus Associated Oncogenesis /Peter L. Stern and Mark H. Einstein --The Epidemiology of Cervical Cancer /Xavier Castellsagué, Laia Bruni, Laia Alemany, Mireia Diaz and Silvia de Sanjosé, et al. --The Basic Elements of a Correct Diagnosis: From Cytohistopathology to Screening /Franco Borruto and Ciro Comparetto --Human Papillomavirus DNA Testing: What, How, and When /Ciro Comparetto and Franco Borruto --Colposcopic Appearance of HPV Infection /Santiago Dexeus, Montserrat Cararach and Damian Dexeus --Multiple Aspects of Human Papillomavirus Infections /Franco Borruto and Ciro Comparetto --Prevention of HPV-Associated Diseases in the United States /Diane M. Harper --Immunogenicity, Efficacy, Effectiveness and Overall Impact of HPV Vaccines /Matti Lehtinen, Pekka Nieminen, Dan Apter, Proscowa Namujju and Kari Natunen, et al. --Treatment, Follow-up, and Prevention of Papillomavirus Infection and Cervical Cancer /Franco Borruto and Ciro Comparetto --Therapeutic Vaccines for HPV Infection /Margaret Stanley --Perspectives on Therapeutic HPV Vaccines: Where Are We Now? /Connie Wang, Barbara Ma, Alexander Chen, Chien-Fu Hung and T. C. Wu.
  • Human cancer viruses 2008, Karger
    Molecular epidemiology of human papillomavirus infection -- / Gillison, M.L -- Molecular pathogenesis of the human papillomavirus / Mao, C.-P., Wu, T.-C -- Human papillomavirus vaccines / Roden, R., Hung, C.-F., Monie, A., Wu, T.-C -- Hepatitis C virus genetics and the discovery of mechanism based inhibitors of the Ns3/4A protease and NS5B polymerase / LaFemina, R.L -- Role of the hepatitis B virus in hepatocellular carcinoma / Toh, S.-T., Lee, C.G -- Carcinogenesis induced by hepatitis B virus / Cougot, D., Buendia, M.-A., Neuveut, C -- Disease and pathogenesis associated with Epstein-Barr virus / Ambinder, R.F -- The biology and molecular biology underlying Epstein-Barr virus oncogenesis / Martin, H.J., Hayward, S.D -- Kaposi-sarcoma-associated herpesvirus clinical diseases and viral pathogenesis / Damania, B., Dittmer, D.P. -- Molecular biology of human herpesvirus 8 neoplasia / Chaudhary, P.M., Nicholas, J -- Human cancer viruses. Human T cell leukemia virus type 1 and 2: mechanisms of pathogenesis / Arnold, J., Green, P.L -- Chromosomal instability and human T cell leukemia virus 1 transformation / Chi, Y.-H., Jeang, K.-T.
  • Pt. 1. Multistep models -- pt. 2. Prostate cancer/stem cells -- pt. 3. Breast cancer/stem cells -- pt. 4. Multistep/genes.
  • Human papillomavirus 2009, Springer
  • 1. Human Papillomavirus (HPV) infection -- 2. Studies of cancer in humans -- 3. Studies of animal papillomaviruses -- 4. Molecular mchanisms of HPV-induced carcinogenesis -- 5. Summary of data reported and evaluation -- 6. References
  • Association between cancer and "acid mucopolysaccharides" : an old concept comes of age, finally -- Hyaluronan-CD44 interactions and chemoresistance in cancer cells -- Growth factor regulation of hyaluronan deposition in malignancies -- Hyaluronan binding protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development -- CD44 meets Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of Merlin -- Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression -- Adhesion and penetration : two sides of CD44 signal transduction cascades in the context of cancer cell metastasis -- Involvement of CD44, a molecule with a thousand faces, in cancer dissemination -- RHAMM/HMMR : an itinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation -- Altered hyaluronan biosynthesis in cancer progression --Hyaluronidase : both a tumor promoter and suppressor -- The hyaluronidases in cancer biology -- Hyaluronan fragments : informational polymers commandeered by cancers -- Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan -- The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression -- Hyaluronan synthesis and turnover in prostate cancer -- Role of hyaluronan in melanoma progression -- Role of hyaluronan metabolism in the initiation, invasion, and metastasis of breast cancer -- Clinical use of hyaluronidase in combination cancer chemotherapy : a historic perspective -- Exploring the hyaluronan:CD44 interaction for cancer therapy -- Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that cause contagious respiratory tract cancers.
  • Ch. 1. Emerging roles for hyaluronidase in cancer metastasis and therapy -- Ch. 2. Targeting hyaluronic acid family for cancer chemoprevention and therapy -- Ch. 3. Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression -- Ch. 4. Hyaluronan synthases posttranslational regulation in cancer -- Ch.4. Hyaluronan synthases posttranslational regulation in cancer -- Ch. 5. Hyaluronan-coated extraellular vesicles, a novel link between hyaluronan and cancer -- Ch.6.Hyaluronan in the healthy and malignant hematopoietic microenvironment -- Ch. 7. Hyaluronan regulation of endothelial barrier function in cancer -- Ch. 8. HAS2 and CD44 in breast tumorigenesis -- Ch. 9. CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals -- Ch. 10. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression -- Ch. 11. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer -- Ch.12. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors -- Ch. 13. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance -- Index.
  • "Advances in computed tomography have made it possible to detect small lung cancers, which has changed lung cancer surgery from lobectomy to a lesser lobar resection such as a segmentectomy or wedge resection. Although wedge resection is a simple procedure, it has a higher risk of hilar lymph node or surgical margin recurrence than does a lobectomy. On the other hand, segmentectomy is a well-known curative surgery for small lung cancers. It is difficult to perform accurately, however, because of its anatomical complexity, which makes surgeons hesitant to use it. Illustrated Anatomical Segmentectomy for Lung Cancer provides readers a detailed explanation of segmentectomy with numerous easy-to-understand color illustrations showing the precise segmental anatomies for each pattern of the procedure. To better illustrate an accurate anatomical segmentectomy, the text shows details of anatomy during the procedure. Up to 25 patterns can be involved, each of which is shown in approximately 10 illustrations."--publisher's website
  • Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation.
  • "This book provides complete descriptions of the techniques involved in medical image processing, using sufficient descriptions and practical references. Chapters cover topics of deformable registration, segmentation, image reconstruction, and integration of these practices into the radiation therapy environment. The four sections provide an overview of the image segmentation and reconstruction techniques using image processing across all modalities, and applications of these approaches in radiation therapy. The book also addresses the applications of registration, segmentation, and image reconstruction for radiation therapy, including adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results"--Provided by publisher.
  • Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few), and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the books Foreword: The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics. This book is an outstanding contribution to the literature and will become a must read for all physicians who are interested in Interventional Oncology.
  • "Preface This book presents key image-guided radiation treatment (IGRT) technologies for external beam radiotherapy and caps a multidecade phase of technology development in the realm of conformal, customized radiation treatment. This development phase has been somewhat brief and vigorous, with new IGRT innovations such as increased image fidelity and adaptive radiotherapy continuing through the present day. IGRT had been in development in earnest since the early 1990s as a desired companion to intensity-modulated radiation treatment (IMRT). It was known at the time that beam-intensity modulation would be proven to enable beamlets of radiation dose to be formed and delivered to give highly conformal treatment to target volumes, while at the same time providing avoidance of even nearby normal structures. IMRT was being developed with pathways that were based on particular technological features of each vendor's designs for their multileaf collimators (MLCs) and linear accelerators, e.g., leaf design (width, height, focus, speed, etc.), dose rate control, error checking, and gantry motion control. In a previous decade, the 1980s into the mid-1990s, three-dimensional conformal radiation treatment (3D-CRT) had been developed such that for the first time, using static pretreatment 3D images from computed tomography (CT), anatomical volumes could be identified and segmented for the target, normal structures, and the external contour. As 3D-CRT and IMRT technologies developed, it was recognized that confirming "correct" treatment geometry for every individual fraction might be important, since daily variations in treatment position and the locations of internal structures would lead to blurring (degradation) of the cumulative dose distribution"--Provided by publisher.
  • Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.
  • This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy, and chemotherapy. Normal and pathological findings are displayed in detailed MR images that illustrate the potential modifications due to treatment. Particular emphasis is placed on characteristic appearances on the newer functional MR imaging techniques, including MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. These techniques are revolutionizing neuroradiology by going beyond the demonstration of macroscopic alterations to the depiction of preceding metabolic changes at the cellular and subcellular level, thereby allowing earlier and more specific diagnosis. A key section comprising some 40 clinical cases and more than 500 illustrations offers an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, radiotherapists, and medical oncologists.
  • Imaging in oncology 2008, Springer
    Anatomic, physiologic and metabolic imaging in neuro-oncology / Sanjeev Chawla, Harish Poptani, and Elias R. Melhem -- Imaging of spinal tumors / Izlem Izbudak ... [et al.] -- PET imaging of brain tumors / Alan J. Fischman -- Extracranial head and neck neoplasms: role of imaging / Myria Petrou and Suresh K. Mukherji -- Imaging of thoracic malignancies / Subba R. Digumarthy and Suzanne L. Aquino -- Imaging of mediastinal tumors / Scott Moore, Hetal Dave-Verma, and Ajay Singh -- Imaging cardiac tumors / Mannudeep K. Kalra and Suhny Abbara -- Diagnostic imaging and image-guided interventions of hepatobiliary malignancies / Unni Udayasankar ... [et al.] -- Recent advances in imaging of pancreatic neoplasms / Chad B. Rabinowitz, Hima B. Prabhakar, and Dushyant V. Sahani -- Imaging of colorectal carcinoma / Jorge A. Soto -- Imaging of primary malignant tumors of peritoneal and retroperitoneal origin / J. Louis Hinshaw and Perry J. Pickhardt -- Imaging of urinary tract tumors / Michael A. Blake and Mannudeep K. Kalra -- Current status of imaging for adrenal malignant involvement / Michael A. Blake and Mannudeep K. Kalra -- Recent advances in imaging of male reproductive tract malignancies / Jurgen J. Fütterer and J. Roan Spermon -- Imaging of malignant skeletal tumors / Jay Pahade, Aarti Sekhar, and Sanjay K. Shetty -- Radiology of soft tissue tumors including melanoma / M.J. Shelly, P.J. MacMahon, and S. Eustace -- Reticuloendothelium malignancy: current role of imaging / Sunit Sebastian and Brian C. Lucey -- Pediatric malignancies: synopsis of current imaging techniques / Sabah Servaes ... [et al.] -- Interventional radiology in oncology / O.J. O'Connor, J. M. Buckley, and M. M. Maher -- Breast tumor imaging / Deirdre Coll
  • Imaging of kidney cancer 2006, Springer
  • Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Benign fibrous and fibrohistiocytic tumors -- Malignant fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic lesions -- Synovial tumors -- Extraskeletal osseous and cartilaginous lesions -- Tumors of uncertain histogenesis -- Masses which may mimic soft tissue tumors -- Compartmental anatomy.
  • Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle --The Functions of HSP70 in Normal Cells --HSP70 in Damaged Cells --Mechanisms of Activation and Inactivation of HSP70 Synthesis --HSP70 in the Immune Responses --HSP70 in Carcinogenesis --HSP70 in aging --The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • Immunotherapy of cancer 2006, Springer
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • Immunotherapy of cancer 2010, Springer Protocols
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • Novel antineoplastics targeting genetic changes in colorectal cancer / Jamal Joudeh...[et al.] -- Update on clinical trials: genetic targets in breast cancer / Bora Lim, Leah V. Cream, Harold A. Harvey -- Impace of genetic targets on cancer therapy in esophagogastric cancer / Yixing Jiang -- Impact of genetic targets on cancer therapy: hapatocellular cancer / Osama Hamed...[et al.] -- Toward the goal of personalizaed therapy in pancreatic cancer by targeting the molecular phenotype / Nelson S. Yee -- Impact of genetic markers on treatment of non-small cell lung cancer / Nicholas Lamparella, Amit Barochia, Salah Almokadem -- Impact of genetic targets on therapy in head and neck squamous cell carcinoma / Irina Chaikhoutdinov, David Goldenberg -- Tyrosine kinase targeted treatment of chronic myelogenous leukemia and other myeloproliferative neoplasms / Ajit Bisen, David F. Claxton -- Targeted tehrapy of multiple myeloma / Nathan G. Dolloff, Giampaolo Talamo -- Current and future trials of targeted therapies and cutaneous melanoma / Matthew S. Evans...[et al.] -- Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma / Vikas Ghai...[et al.] -- Impact of genetic targets on primary brain tumor therapy: what's ready for prime time / O. Zalatimo...[et al.] -- Rational therapy for renal cell carcinoma based on its genetic targets / Jaime Messer, Joseph Drabick, Matthew Kang -- Molecular and genetic markers of follicular-cell thyroid cancer : etiology and diagnostic and therapeutic opportunities / Neerav Goyal...[et al.] -- Genetic targets in pediatric acute lymphoblastic leukemia / Chandrika Gowda, Sinisa Dovat -- Emerging molecular therapies for the treatment of acute lymphoblastic leukemia / Monali Vasekar...[et al.] -- Impact of genetic targets on prostate cancer therapy / Hassan Sheikh...[et al.] -- Small-cell lung cancer : an update on targeted therapues / Monika Joshi, Ayodele Ayoola, Chandra P. Belani -- Impact of genetic targets on cancer therapy in acute myelogenous leukemia / Mithun Vinod Shah, Amit Barochia, Thomas P. Loughran.
  • IMRT, IGRT, SBRT 2007, Karger
  • Over the last 4 years, IMRT, IGRT, SBRT: Advances in the Treatment Planning and Delivery of Radiotherapy has become a standard reference in the field. During this time, however, significant progress in high-precision technologies for the planning and delivery of radiotherapy in cancer treatment has called for a second edition to include these new developments. Thoroughly updated and extended, this new edition offers a comprehensive guide and overview of these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity-modulated radiothera.
  • Induction chemotherapy 2011, Springer
  • In remembrance of Rudolf Virchow (1821-1902) / Schmidt, A. -- In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia / Schmidt, A., Weber, O.F. -- Aneuploidy and cancer: from correlation to causation / Duesberg, P. ... [et al.] -- Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells / Trosko, J.E., Tai, M.-H. -- Helicobacter pylori and gastric neoplasia / Leung, W.K. -- Schistosomiasis and neoplasia / Yosry, A. -- Relevant oncogenic viruses in veterinary medicine: original pathogens and animal models for human disease / Truyen, U., L"chelt, M. -- The inflammatory tumor microenvironment and its impact on cancer development / de Visser, K.E., Coussens, L.M. -- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? / Pawelek, J. ... [et al.] -- Carcinogenesis driven by bone marrow-derived stem cells / Dittmar, T. ... [et al.] -- Chemokine-directed metastasis / Gomperts, B.N., Strieter, R.M. -- Involvement of chemokine receptors in organ-specific metastasis / Zlotnik, A. -- Visualization of tumor cell extravasation / Heyder, C. ... [et al.] -- Options for visualizing metastatic disease in the living body / Helms, M.W., Brandt, B.H., Contag, C. -- Infection, inflammation and neoplasia: an interdisciplinary challenge / Zaenker, K.S.
  • The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
  • While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neoplastic disease. In this patient population, infection risk results from a complex interplay between the host's underlying immunodeficiencies, local tumor effects, and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book, is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach, and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management, and prevention of infection and optimization of the overall care of patients with malignancies.
  • Inflammation and cancer 2014, Springer
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
  • Inflammation and cancer v. 1-2, 2009, Springer Protocols
    v. 2, 2009 Springer Protocols
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • Basic concepts of inflammation and its role in carcinogenesis -- Inherited syndromes predisposing to inflammation and GI cancer -- Stem cells and inflammation in the intestine -- Acid reflux and oesophageal cancer -- Helicobacter pylori and gastric cancer -- Inflammatory bowel disease and colon cancer -- Primary sclerosing cholangitis -- Chronic inflammation and hepatocellular carcinoma -- Gastrointestinal cancer: current screening strategies -- Targeted drug therapies and cancer -- Genetics of inflammation in the gastrointestinal tract and how it can cause cancer -- Endoscopic methods.
  • Section I. Inflammation, oxidative stress, nutritional phytochemicals, and cancer -- section II. Signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals -- section III. In vivo absorption and pharmacokinetics of nutritional phytochemicals -- section IV. Vitamins A, D, and E cancer prevention and clinical perspective -- section V. Omega-3 and omega-6 fatty acids -- section VI. Flavonoids and polyphenols -- section VII. Garlic organosulfur compounds and crucifer glucusinolates -- section VIII. Selenium, herbal medicines, alpha lipoic acid, and cancer prevention -- section IX. Epigenetics and chronic inflammation.
  • Introduction: Why IBC Now? /Naoto T. Ueno and Massimo Cristofanilli --Epidemiology of Inflammatory Breast Cancer /Shannon Wiggins, Sarah Taylor and Melissa Bondy --Clinical Aspect of Inflammatory Breast Cancer: Diagnosis, Criteria, Controversy /Shaheenah Dawood and Vicente Valero --Inflammatory Breast Cancer Registry /Jie S. Willey and Naoto T. Ueno --Pathology: Histomorphometrical Features of IBC - Angiogenesis, Lymphangiogenesis, and Tumor Emboli /Sanford H. Barsky and Fredika M. Robertson --Imaging for the Diagnosis and Staging of IBC /Wei Tse Yang --Surgical Therapy for Inflammatory Breast Cancer /Sarah M. Gainer, Hideko Yamauchi and Anthony Lucci --Radiation Therapy for Inflammatory Breast Cancer /Thomas A. Buchholz, Ian Bristol and Wendy Woodward --Systemic and Targeted Therapy /Hideko Yamauchi, Teruo Yamauchi, Naoto T. Ueno and Vicente Valero --Inflammatory Breast Cancer: Chemotherapy of Metastatic Disease /Anthony Gonçalves and Patrice Viens --The Role of the Multidisciplinary Team in Inflammatory Breast Cancer /Nabila Chowdhury and Sandra M. Swain --High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Inflammatory Breast Cancer /Yee Chung Cheng and Naoto T. Ueno --Models of Inflammatory Breast Cancer /Lara Lacerda and Wendy A. Woodward --Signaling Pathways in Inflammatory Breast Cancer /Dongwei Zhang and Naoto T. Ueno --Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer /Madhura Joglekar and Kenneth L. van Golen --Inflammatory Mediators as Therapeutic Targets for Inflammatory Breast Cancer /Fredika M. Robertson, Khoi Chu, Rita Circo, Julia Wulfkuhle and Lance Liotta, et al. --Immunology of Inflammatory Breast Cancer /James M. Reuben and Bang-Ning Lee --Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study /Peter B. Vermeulen, Gert Van den Eynden, Pascal Finetti, Daniel Birnbaum and Naoto T. Ueno, et al. --Microarray Analysis Identifies an Expression Signature for Inflammatory Breast Cancer /François Bertucci, Pascal Finetti, Max Chaffanet, Patrice Viens and Daniel Birnbaum --Cell Gene Expression Signatures in Inflammatory Breast Cancer /Wendy A. Woodward --The Effect of Systemic Chemotherapy on Minimal Residual Disease in the Blood and Bone Marrow of Patients with Inflammatory Breast Cancer /Luc Y. Dirix, Dieter Peeters, Steven Van Laere and Peter B. Vermeulen --Perspective of Patient Advocacy /Michelle Esteban and Patti Bradfield.
  • Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs in women of all ages, and, rarely, in men. Variable disease presentation means that this disease is often undetected and patients with this diagnosis have a poor prognosis.Inflammatory Breast Cancer brings together the existing clinical information on inflammatory breast cancer. The content covers epidemiology, risk factors, diagnosis, histopathology and staging, therapy and management of patients with this disease. Recent advances in therapy have improved the prognosis of this type of cancer considerably, making this text a timely addition to the literature.This book is an essential tool for medical, surgical and clinical oncologists specialising in breast cancer, who will inevitably encounter this rare but pernicious disease.
  • "A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
  • Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale

Shortcut to Licensed Content

Lane Gateway to Licensed Content

Bookmark on other websites

Bookmark on Lane
  • Select "Add to Favorites" (click “Continue” if you see a security alert)
  • From the "Create in" menu, select “Links” (IE7) or “Favorites Bar” (IE8, IE9) to install
  • Once installed it will look like this
  • Click "Bookmark on Lane" to bookmark any webpage
  • Your saved bookmark will appear on this page

Shortcut for iPhone

Lane Gateway to Licensed Content

  • Drag this button to your Safari bookmarks bar
  • Open iTunes and sync your iPhone; make sure "Sync Safari Bookmarks" under iPhone Info tab is selected
  • To invoke the bookmarklet on your iPhone, open Safari and tap the "Bookmarks" icon
  • Tap "Bookmarks Bar"
  • Tap "Lane Proxy Bookmarklet"

What is it?

This shortcut (Lane proxy bookmarklet) gives you access to resources licensed by the library even when you're not coming from a Lane or a Stanford IP address.

While we'd like Lane to be your gateway to our licensed content, we recognize that links to books, articles and journals come from a variety of different sources (Google, your email, RSS reader, etc.).

Lane Proxy Bookmarklet in the Bookmarks Bar

When installed, it will look your browser bookmark.

At the page you would like to proxy, click the "Lane Gateway to Licensed Content" to invoke it.

If Lane licenses that content, you'll get access as if you were on campus.

How does it work?

This shortcut (Lane proxy bookmarklet) is a combination of a browser bookmark and a JavaScript application. In other words, it's a bookmark that can be programmed to do things. The Lane proxy bookmarklet simply prepends the Lane proxy URL to the current URL in your browser.

This allows you to view the URL as though you were on campus, giving you access to materials licensed for use by the Stanford academic community.

If you're not authenticated, you'll be prompted for your SUNetID and password.

Don't see the Toolbar, Bookmarks, or Links or Favorites bar?

FireFox

From the "View" menu, select "Toolbars" & choose "Bookmarks Toolbar"

Safari

From the "View" menu, choose "Show Bookmarks Bar"

Chrome

From the "View" menu, choose "Always Show Bookmarks Bar"

Internet Explorer

IE controller bar
  • Right-click in a clear area near the browser address bar
  • In the menu, check a box next "Links" (IE7) or "Favorites" (IE8, IE9)
  • Managing IE Favorites

Caveats

This shortcut (Lane proxy bookmarklet) only works with resources Lane has licensed and configured to work with our proxy server.

If invoked on a resource we do not license and/or have not yet configured, you will see an error message:

The Lane proxy server cannot complete your request because this host has not been configured properly.

We make no attempt to configure our proxy server for every resource, only those we license and for which a Stanford IP address grants access.

Drag this button onto your browser toolbar to install.

  • Right click this button
  • Select "Add to Favorites", click "Continue" if you see a security alert
  • In "Create in" menu, select "Links" (IE7) or "Favorites Bar" (IE8, IE9) to install

Drag this button onto Safari Bookmarks bar to install.

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